Topical scalp composition

Abstract

To provide a topical scalp composition that can suppress scalp odor while reducing scalp itching.SOLUTION: Provided is a topical scalp composition comprising (A) a heparin-like substance and (B) diphenhydramine and / or a salt thereof, the composition having a viscosity of 140 Pa s or less.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present disclosure relates to compositions for topical application to the scalp. [Background technology]

[0002] Heparinoids have been reported to have skin moisturizing effects, blood circulation promoting effects, anti-inflammatory effects, etc. Based on these effects, they are incorporated into pharmaceuticals, quasi-drugs, cosmetics, etc. in the hope of alleviating dry skin symptoms, asteatosis, keratoderma tylodes palmaris progressiva, chilblains, hypertrophic scars and keloids, pain or inflammatory diseases caused by impaired blood circulation, thrombophlebitis, swelling and hematoma after trauma (bruises, sprains, contusions), tendonitis, muscle pain, arthritis, etc.

[0003] Diphenhydramine is also a histamine H1 receptor antagonist and is used in pharmaceuticals as an antipruritic ingredient for the skin. Summary of the Invention [Problem to be solved by the invention]

[0004] Among skin tissues, the scalp is known to have a larger number of sebaceous glands and sweat glands than other skin tissues, resulting in greater secretion of sebum and sweat. The sebum secreted from the skin tissue is decomposed by the resident bacteria present on the skin surface. As a result, the sebum is decomposed into fatty acids, which irritate the skin tissue. The fatty acids produced by decomposition also cause odor. Therefore, among skin tissues, the scalp in particular has a unique problem of being prone to odor (scalp odor) in addition to the itching that occurs in other skin tissues.

[0005] Therefore, an object of the present disclosure is to provide a composition for external use on the scalp that can suppress scalp odor while suppressing scalp itching. [Means for solving the problem]

[0006] To achieve the above-mentioned objective, the scalp topical composition of the present disclosure contains (A) a heparinoid and (B) diphenhydramine and / or its salt, and has a viscosity of 140 Pa·s or less.

[0007] The topical scalp product of the present disclosure comprises the topical scalp composition of the present disclosure and a container having a drop-type, pen-type, sponge-type, or spray-type discharge portion, and the topical scalp composition is contained in the container.

[0008] The method for imparting scalp odor suppressing effects to an external composition of the present disclosure includes an adjustment step of adjusting the viscosity of an external composition containing (A) a heparinoid and (B) diphenhydramine and / or its salt to 140 Pa·s or less. [Effects of the Invention]

[0009] The scalp external composition of the present disclosure can suppress scalp odor while suppressing scalp itching. DETAILED DESCRIPTION OF THE INVENTION

[0010] The present disclosure will be specifically described below using examples. Unless otherwise specified, each disclosure may incorporate the explanations of other disclosures.

[0011] <Scalp external composition> In one embodiment, the present disclosure provides a composition for topical application to the scalp (hereinafter also referred to as the "composition"), which, as described above, contains (A) a heparinoid and (B) diphenhydramine and / or a salt thereof, and has a viscosity of 140 Pa s or less, but other components and conditions are not particularly limited.

[0012] As a result of extensive research, the present inventors discovered that by reducing the viscosity of a composition containing a heparinoid and diphenhydramine and / or a salt thereof to 140 Pa·s or less, scalp itching and scalp odor can be suppressed, leading to the establishment of the present disclosure. It is presumed that this is because, by reducing the viscosity of the topical scalp composition of the present disclosure to 140 Pa·s or less, upon contact with the scalp, the interaction between the topical scalp composition and scalp odor-causing substances is strengthened, making it easier for the topical scalp composition to retain the causative substances, thereby suppressing scalp odor. However, the present disclosure is not limited to this presumption. Therefore, the present disclosure provides a topical scalp composition that can suppress scalp itching and scalp odor. Furthermore, the topical scalp composition of the present disclosure can improve the compatibility of the composition with water by, for example, adjusting the viscosity of the composition to 140 Pa·s or less, thereby improving the compatibility of the composition with the scalp when brought into contact with the scalp. Furthermore, the composition can be easily applied even when the scalp surface is wet, such as after washing hair or sweating while wearing a hat. Therefore, the topical scalp composition of the present disclosure can effectively suppress scalp itching by combining the heparinoid and diphenhydramine and / or a salt thereof, regardless of the condition of the scalp.

[0013] ((A) Heparinoids) The heparinoid (hereinafter simply referred to as "component (A)"), which is component (A), is not particularly limited as long as it is pharmaceutically, pharmacologically (pharmaceutical), or physiologically acceptable. The heparinoid is a substance known as a mucopolysaccharide polysulfate ester or heparinoid, which is a mucopolysaccharide having a repeating disaccharide structure of D-glucuronic acid and N-acetyl-D-galactosamine, to which a large number of sulfate groups have been introduced. The heparinoid is preferably a heparinoid listed in the Japanese Pharmacopoeia (JPN) Standards. The amount (%) of organic sulfate groups in the heparinoid is not particularly limited, but is preferably 25 to 38% from the viewpoint of medicinal effects such as moisturizing effect. The amount of organic sulfate groups can be measured, for example, by the method described in the section on "heparinoids" in the Japanese Pharmacopoeia (JPN) Standards.

[0014] The content of the heparinoid is not particularly limited and may be, for example, 0.01 to 1 mass%, 0.05 to 0.5 mass%, 0.1 to 0.4 mass%, 0.1 to 0.3 mass%, or 0.2 to 0.3 mass%, based on the total mass of the composition for external use on scalp of the present disclosure. By making the content of the heparinoid 0.1 mass% or more, the composition for external use on scalp of the present disclosure can, for example, more significantly exhibit the effects of the composition for external use on scalp of the present disclosure, and can also moisturize the scalp and suppress itching.

[0015] ((B) Diphenhydramine and / or its salts) The diphenhydramine (hereinafter simply referred to as "component (B)"), which is component (B), is not particularly limited as long as it is medicamentarily, pharmacologically (pharmaceutical), or physiologically acceptable. The diphenhydramine is a compound represented by N,N-dimethyl-2-(diphenylmethoxy)ethylamine, and exhibits antihistamine activity. An example of a salt of diphenhydramine is diphenhydramine hydrochloride. Among the components (B), diphenhydramine is preferred.

[0016] The content of diphenhydramine and / or its salt is not particularly limited and may be, for example, 0.01 to 10% by mass, 0.05 to 5% by mass, 0.1 to 3% by mass, 0.5 to 2% by mass, 0.8 to 1.5% by mass, or 0.9 to 1.1% by mass, based on the total mass of the composition for external use on scalp. By making the content of diphenhydramine and / or its salt 0.01% by mass or more, the composition for external use on scalp of the present disclosure can, for example, more significantly exhibit the effects of the composition for external use on scalp of the present disclosure and can suppress itching.

[0017] The content ratio of the (B) component to the (A) component in the scalp topical composition of the present disclosure is not particularly limited and is appropriately set depending on the types of the (A) component and the (B) component, the types and contents of other blended components, the intended use of the composition, the formulation form, etc. From the viewpoint of further enhancing the effect of the scalp topical composition of the present disclosure, the content ratio of the (B) component to the (A) component is, for example, preferably 0.1 to 10 parts by mass, more preferably 1 to 7 parts by mass, and even more preferably 3 to 4 parts by mass, of the total content of the (B) component per 1 part by mass of the total content of the (A) component contained in the scalp topical composition according to this embodiment.

[0018] (viscosity) The upper limit of the viscosity of the topical scalp composition of the present disclosure is 140 Pa·s or less, preferably 110 Pa·s or less, and more preferably 105 Pa·s or less. The lower limit of the viscosity of the topical scalp composition of the present disclosure is not particularly limited, and is, for example, 0 Pa·s or more, 1 Pa·s or more, preferably 5 Pa·s or more, 10 Pa·s or more, more preferably 50 Pa·s or more, and even more preferably 70 Pa·s or more. The viscosity of the topical scalp composition of the present disclosure is typically 0 to 140 Pa·s, 1 to 140 Pa·s, preferably 10 to 140 Pa·s, more preferably 50 to 110 Pa·s, and even more preferably 70 to 105 Pa·s. By setting the viscosity of the topical scalp composition of the present disclosure to 140 Pa·s or less, the scalp odor suppression effect and the effect of improving water compatibility can be effectively achieved, and by setting the viscosity to 110 Pa·s or less, these effects can be more suitably achieved.

[0019] The viscosity can be measured using a Brookfield viscometer (single cylinder rotational viscometer (Brookfield viscometer)) in accordance with the viscosity measurement method described in the General Test Methods of the 18th Edition of the Japanese Pharmacopoeia. Specifically, the viscosity can be determined, for example, by measuring using a Brookfield viscometer at a temperature of 25°C and a rotation speed of 0.6 rpm. The viscosity measurement method can be carried out, for example, under the following conditions. The single cylinder rotational viscometer is a viscometer that measures the torque when a cylinder in a liquid is rotated at a constant angular velocity. (Viscosity measurement conditions) Measuring equipment: TVB-15 viscometer (Toki Sangyo Co., Ltd.) Rotor: M4 rotor (Toki Sangyo Co., Ltd.) ·Temperature: 25℃ Rotation speed: 0.6 rpm Vial size: 40mm x 75mm Sample size: 50g

[0020] The viscosity can be adjusted, for example, by using a thickener, such as by adjusting the amount of a thickener (such as an alkyl copolymer (acrylic acid-based polymer) such as a carboxyvinyl polymer) added, or by adjusting the pH.

[0021] ((C) component) The topical scalp composition of the present disclosure may further contain, as component (C), one or more selected from the group consisting of (C1) crotamiton; (C2) pantothenic acid, its derivatives, and salts thereof; (C3) terpenoids; and (C4) glycyrrhizic acids. In this case, the topical scalp composition of the present disclosure preferably contains, for example, one or more of the components (C1) to (C4).

[0022] ((C1) Crotamiton) The component (C1) crotamiton (hereinafter simply referred to as "component (C1)") is not particularly limited as long as it is pharmaceutically, pharmacologically (pharmaceutical), or physiologically acceptable. Crotamiton is a compound represented by N-ethyl-N-(2-methylphenyl)but-2-enamide. Crotamiton is generally used as an antipruritic component in topical compositions.

[0023] When the composition for external use on the scalp of the present disclosure contains the crotamiton (C1), the content of the crotamiton (C1) is, for example, 0.5 to 10% by mass, preferably 1 to 8% by mass, more preferably 2 to 7% by mass, and even more preferably 4 to 6% by mass, based on the total mass of the composition for external use on the scalp. By making the content of the crotamiton (C1) 0.5% by mass or more, the composition for external use on the scalp of the present disclosure can, for example, more significantly exhibit the effects of the composition for external use on the scalp of the present disclosure and suppress itching.

[0024] In the topical scalp composition of the present disclosure, the content ratio of the (C1) component to the (A) component is not particularly limited and is appropriately set depending on the types of the (A) component and the (C1) component, the types and contents of other blended components, the intended use of the composition, the formulation form, etc. From the viewpoint of further enhancing the effect of the topical scalp composition of the present disclosure, the content ratio of the (C1) component to the (A) component is, for example, preferably 1 to 50 parts by mass, more preferably 10 to 20 parts by mass, and even more preferably 15 to 17 parts by mass, of the total content of the (C1) component per 1 part by mass of the total content of the (A) component contained in the topical scalp composition of this embodiment.

[0025] In the scalp topical composition of the present disclosure, the content ratio of the (C1) component to the (B) component is not particularly limited and is appropriately set depending on the types of the (B) component and the (C1) component, the types and contents of other blended components, the intended use of the composition, the formulation, etc. From the viewpoint of further enhancing the effect of the scalp topical composition of the present disclosure, for example, the content ratio of the (C1) component to the (B) component is preferably 0.5 to 10 parts by mass, more preferably 1 to 8 parts by mass, even more preferably 2 to 7 parts by mass, and even more preferably 4 to 6 parts by mass, of the total content of the (C1) component relative to 1 part by mass of the total content of the (B) component contained in the scalp topical composition of this embodiment.

[0026] ((C2) Pantothenic acid, its derivatives, and their salts) The pantothenic acid, its derivatives, and salts thereof (hereinafter simply referred to as "component (C2)"), which are the component (C2), are not particularly limited as long as they are medicamentarily, pharmacologically (pharmaceutical), or physiologically acceptable. Pantothenic acid has the effect of promoting the metabolism of energy from carbohydrates, proteins, lipids, etc., and is known to exhibit useful physiological activities such as cell activation, metabolic activation, moisturizing, and resistance enhancement. Examples of the pantothenic acid derivatives include panthenol, pantothenyl ethyl ether (pantothenyl ethyl ether), and acetylpantothenyl ethyl ether (acetylpantothenyl ethyl ether). Examples of the salts of the derivatives include alkali metal salts such as sodium and potassium; ammonium salts; and the like. Examples of the pantothenic acid salts include calcium pantothenate and sodium pantothenate. The pantothenic acid, its derivatives, and salts thereof may be used alone or in combination.

[0027] When the scalp external composition of the present disclosure contains the (C2) pantothenic acid, its derivatives, and salts thereof, the content of the (C2) pantothenic acid, its derivatives, and salts thereof is, for example, 0.01 to 10% by mass, 0.05 to 5% by mass, 0.1 to 3% by mass, 0.5 to 2% by mass, 0.8 to 1.5% by mass, or 0.9 to 1.1% by mass, based on the total mass of the scalp external composition. By making the content of the pantothenic acid, its derivatives, and salts thereof 0.01% by mass or more, the scalp external composition of the present disclosure can, for example, more significantly exhibit the effects of the scalp external composition of the present disclosure, improve the scalp barrier function, and suppress itching.

[0028] The content ratio of the (C2) component to the (A) component in the external scalp composition of the present disclosure is not particularly limited and is appropriately set depending on the types of the (A) component and the (C2) component, the types and contents of other blended components, the intended use of the composition, the formulation form, etc. From the viewpoint of further enhancing the effect of the external scalp composition of the present disclosure, the content ratio of the (C2) component to the (A) component is, for example, preferably 0.1 to 10 parts by mass, more preferably 1 to 5 parts by mass, and even more preferably 3 to 4 parts by mass, of the total content of the (C2) component relative to 1 part by mass of the total content of the (A) component contained in the external scalp composition according to this embodiment.

[0029] In the scalp topical composition of the present disclosure, the content ratio of the (C2) component to the (B) component is not particularly limited and is appropriately set depending on the types of the (B) component and the (C2) component, the types and contents of other blended components, the intended use of the composition, the formulation, etc. From the viewpoint of further enhancing the effect of the scalp topical composition of the present disclosure, for example, the content ratio of the (C2) component to the (B) component is preferably 0.01 to 10 parts by mass, more preferably 0.05 to 5 parts by mass, even more preferably 0.1 to 3 parts by mass, even more preferably 0.5 to 2 parts by mass, particularly preferably 0.8 to 1.5 parts by mass, and most preferably 0.9 to 1.1 parts by mass, relative to 1 part by mass of the total content of the (B) component contained in the scalp topical composition of the present disclosure.

[0030] ((C3) terpenoids) The terpenoid (hereinafter also referred to simply as "(C3) component") as the (C3) component is not particularly limited as long as it is medicamentarily, pharmacologically (pharmaceutical), or physiologically acceptable. Examples of the terpenoid include cyclic terpenes and acyclic terpenes. The cyclic terpene is a terpenoid having at least one ring structure in the molecule. Examples of the cyclic terpene include menthol (e.g., l-menthol), camphor (e.g., d-camphor, dl-camphor), borneol (also known as "ryunou"), menthone, cineole, carvone, anethole, eugenol, limonene, pinene, and derivatives thereof. The acyclic terpene is a terpenoid that does not have a ring structure in the molecule. Examples of the acyclic terpene include geraniol, citronellol, linalool, linalyl acetate, and derivatives thereof. The terpenoid may be any of the d-, l-, or dl-isomers. In the present disclosure, the terpenoid may be an essential oil containing the above-mentioned compound. Examples of the essential oil include eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, peppermint oil, fennel oil, cinnamon oil, and rose oil. For example, one type of terpenoid may be used, or multiple types may be used in combination.

[0031] When the composition for external use on the scalp of the present disclosure contains the terpenoid (C3), the content of the terpenoid is, for example, 0.001 to 20% by mass, 0.01 to 15% by mass, 0.1 to 10% by mass, 0.5 to 8% by mass, 1 to 5% by mass, or 2 to 4% by mass, based on the total mass of the composition for external use on the scalp. By making the content of the terpenoid 0.01% by mass or more, the composition for external use on the scalp of the present disclosure can, for example, more significantly exhibit the effects of the composition for external use on the scalp of the present disclosure and can also suppress itching.

[0032] The content ratio of the (C3) component to the (A) component in the external scalp composition of the present disclosure is not particularly limited and is appropriately set depending on the types of the (A) component and the (C3) component, the types and contents of other blended components, the intended use of the composition, the formulation form, etc. From the viewpoint of further enhancing the effect of the external scalp composition of the present disclosure, the content ratio of the (C3) component to the (A) component is, for example, preferably 0.1 to 50 parts by mass, more preferably 1 to 20 parts by mass, and even more preferably 5 to 15 parts by mass, of the total content of the (C3) component relative to 1 part by mass of the total content of the (A) component contained in the external scalp composition according to this embodiment.

[0033] The content ratio of the (C3) component to the (B) component in the scalp topical composition of the present disclosure is not particularly limited and is appropriately set depending on the types of the (B) component and the (C3) component, the types and contents of other blended components, the intended use of the composition, the formulation, etc. From the viewpoint of further enhancing the effect of the scalp topical composition of the present disclosure, for example, the content ratio of the (C3) component to the (B) component is preferably 0.001 to 20 parts by mass, more preferably 0.01 to 15 parts by mass, even more preferably 0.1 to 10 parts by mass, even more preferably 0.5 to 8 parts by mass, particularly preferably 1 to 5 parts by weight, and most preferably 2 to 4 parts by mass, relative to 1 part by mass of the total content of the (B) component contained in the scalp topical composition of the present disclosure.

[0034] ((C4) Glycyrrhizic acid) The glycyrrhizinic acid compound (hereinafter simply referred to as "component (C4)") serving as component (C4) is not particularly limited as long as it is medicamentarily, pharmacologically (pharmaceutical), or physiologically acceptable. The glycyrrhizinic acid compound may include, as an active ingredient, glycyrrhetic acid, its derivatives (e.g., glycosides), and salts thereof. Glycyrrhetinic acid, a glycoside of glycyrrhizinic acid, is known to exhibit physiological activity similar to that of glycyrrhizinic acid. Therefore, the glycyrrhizinic acid compound encompasses glycyrrhizinic acid, its derivatives, and salts thereof. Glycyrrhetinic acid is a compound represented by 3β-hydroxy-11-oxoolean-12-en-30-oic acid and exhibits anti-inflammatory activity. Examples of the derivatives of glycyrrhizinic acid include stearyl glycyrrhetinate, pyridoxine glycyrrhetinate, glycerin glycyrrhetinate, glycyrrhetinic acid monoglucuronide, and acetylglycyrrhetinic acid. Examples of the salts of glycyrrhetinic acid and its derivatives include alkali metal salts such as sodium and potassium; ammonium salts; etc. Examples of the salts of glycyrrhetinic acid and its derivatives include monoammonium glycyrrhetinate, dipotassium glycyrrhetinate, tripotassium glycyrrhetinate, disodium glycyrrhetinate, trisodium glycyrrhetinate, etc. The glycyrrhizinic acid is a compound represented by 20β-carboxy-11-oxo-30-norolean-12-en-3β-yl-2-O-β-D-glucopyranuronosyl-β-D-glucopyranosiduronic acid or 20β-carboxy-11-oxo-30-norolean-12-en-3β-yl-2-O-β-D-glucopyranuronosyl-α-D-glucopyranosiduronic acid (preferably 20β-carboxy-11-oxo-30-norolean-12-en-3β-yl-2-O-β-D-glucopyranuronosyl-β-D-glucopyranosiduronic acid), and exhibits anti-inflammatory activity. Examples of the glycyrrhizinic acid derivatives include methyl glycyrrhizinate and stearyl glycyrrhizinate. Examples of salts of the derivatives include alkali metal salts such as sodium and potassium salts; ammonium salts; and the like.Examples of the salts of glycyrrhizinic acid include monoammonium glycyrrhizinate, dipotassium glycyrrhizinate, tripotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, etc. The glycyrrhizinic acids may be used, for example, either individually or in combination.

[0035] When the scalp external composition of the present disclosure contains the (C4) glycyrrhizic acid, the content of the (C4) glycyrrhizic acid is, for example, 0.01 to 10 mass%, 0.05 to 5 mass%, 0.1 to 3 mass%, 0.5 to 2 mass%, 0.8 to 1.5 mass%, or 0.9 to 1.1 mass%, based on the total mass of the scalp external composition. By setting the content of the (C4) glycyrrhizic acid to 0.05 mass% or more, the scalp external composition of the present disclosure can, for example, more significantly exhibit the effects of the scalp external composition of the present disclosure and can also suppress scalp inflammation and itching.

[0036] The content ratio of the (C4) component to the (A) component in the external scalp composition of the present disclosure is not particularly limited and is appropriately set depending on the types of the (A) component and the (C4) component, the types and contents of other blended components, the intended use of the composition, the formulation form, etc. From the viewpoint of further enhancing the effect of the external scalp composition of the present disclosure, the content ratio of the (C4) component to the (A) component is, for example, preferably 0.01 to 50 parts by mass, more preferably 0.1 to 10 parts by mass, and even more preferably 1 to 5 parts by mass, of the total content of the (C4) component relative to 1 part by mass of the total content of the (A) component contained in the external scalp composition according to this embodiment.

[0037] In the scalp topical composition of the present disclosure, the content ratio of the (C4) component to the (B) component is not particularly limited and is appropriately set depending on the types of the (B) component and the (C4) component, the types and contents of other blended components, the intended use of the composition, the formulation, etc. From the viewpoint of further enhancing the effect of the scalp topical composition of the present disclosure, for example, the content ratio of the (C4) component to the (B) component is preferably 0.01 to 10 parts by mass, more preferably 0.05 to 5 parts by mass, even more preferably 0.1 to 3 parts by mass, even more preferably 0.5 to 2 parts by mass, particularly preferably 0.8 to 1.5 parts by mass, and most preferably 0.9 to 1.1 parts by mass, relative to 1 part by mass of the total content of the (A) component contained in the scalp topical composition of the present disclosure.

[0038] (thickener) The scalp external composition of the present disclosure preferably further contains a thickener.The thickener can be exemplified by guar gum; locust bean gum; carrageenan; xanthan gum; vinyl polymers such as polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, polyacrylic acid and their salts; acrylic acid alkyl methacrylate copolymer; bentonite; mucopolysaccharides such as alginic acid; macrogol; cellulose thickeners such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxyethylcellulose; etc., and vinyl polymers are preferred, and carboxyvinyl polymers are more preferred.The thickener can be used, for example, by one kind or by a combination of multiple kinds.

[0039] When the external scalp composition of the present disclosure contains the thickener, the content of the thickener is, for example, 0.0001 to 40% by mass, 0.001 to 20% by mass, 0.01 to 10% by mass, 0.05 to 5% by mass, or 0.1 to 2% by mass, based on the total mass of the external scalp composition. By making the content of the thickener 0.1% by mass or more, the external scalp composition of the present disclosure can, for example, more significantly exhibit the effects of the external scalp composition of the present disclosure and can also suppress scalp inflammation and itching.

[0040] The content ratio of the thickener relative to the component (A) in the external scalp composition of the present disclosure is not particularly limited and is appropriately set depending on the type and content of the component (A), the thickener, and other ingredients, the intended use of the composition, the formulation, etc. From the viewpoint of further enhancing the effect of the external scalp composition of the present disclosure, the content ratio of the thickener relative to the component (A) is, for example, preferably 0.0005 to 20 parts by mass, more preferably 0.005 to 10 parts by mass, even more preferably 0.01 to 5 parts by mass, and particularly preferably 0.05 to 2.5 parts by mass, relative to 1 part by mass of the total content of the component (A) contained in the external scalp composition of this embodiment.

[0041] The content ratio of the thickener relative to the component (B) in the topical scalp composition of the present disclosure is not particularly limited and is appropriately set depending on the type and content of the component (B), the thickener, and other ingredients, the intended use of the composition, the formulation, etc. From the viewpoint of further enhancing the effect of the topical scalp composition of the present disclosure, for example, the content ratio of the thickener relative to the component (B) is preferably 0.0001 to 40 parts by mass, more preferably 0.001 to 20 parts by mass, even more preferably 0.01 to 10 parts by mass, particularly preferably 0.05 to 5 parts by mass, and most preferably 0.1 to 2 parts by mass, relative to 1 part by mass of the total content of the component (B) contained in the topical scalp composition of the present disclosure.

[0042] (salts of various compounds) In the scalp topical composition of the present disclosure, salts of various compounds include, for example, pharmaceutically acceptable salts, salts acceptable for quasi-drugs, salts acceptable for cosmetic compositions, etc. In the scalp topical composition of the present disclosure, salts of various compounds form acid addition salts or salts with bases depending on the type of substituent. Examples of the salts include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts; ammonium salts; aliphatic amine salts such as trimethylamine salts, triethylamine salts, dicyclohexylamine salts, ethanolamine salts, diethanolamine salts, and triethanolamine salts; aralkylamine salts such as N,N-dibenzylethylenediamine; heterocyclic aromatic amine salts such as pyridine salts, picoline salts, quinoline salts, and isoquinoline salts; quaternary ammonium salts such as tetramethylammonium salts, tetraethylammonium salts, benzyltrimethylammonium salts, benzyltributylammonium salts, methyltrioctylammonium salts, and tetrabutylammonium salts; amino acid salts such as arginine salts, lysine salts, aspartates, and glutamates; hydrochlorides, sulfates, etc. inorganic acid salts such as acetate, propionate, succinate, glycolate, lactate, maleate, fumarate, tartrate, malate, citrate, ascorbate, hydroxymaleate, pyruvate, phenylacetate, benzoate, 4-aminobenzoate, anthranilate, 4-hydroxybenzoate, salicylate, 4-aminosalicylate, pamoate, gluconate, nicotinate, and the like; and sulfonates such as methanesulfonate, isethionate, ethanesulfonate, benzenesulfonate, halobenzenesulfonate, p-toluenesulfonate, toluenesulfonate, naphthalenesulfonate, sulfanilate, cyclohexylsulfamate, and the like.

[0043] (Form of formulation) The scalp topical composition of the present disclosure can be prepared as a topical composition for a pharmaceutical, quasi-drug, or cosmetic by mixing it with, for example, a base or carrier used in a pharmaceutical, quasi-drug, or cosmetic, an additive, an active ingredient such as a physiologically active ingredient or a pharmacologically active ingredient, or the like.

[0044] The scalp topical composition of the present disclosure may be in the form of, for example, a topical solution, liniment, lotion, ointment, cream, or gel. These formulations can be manufactured according to or in compliance with the methods described in the General Provisions of Preparations of the 18th Edition of the Japanese Pharmacopoeia. The specific uses of the cosmetics and quasi-drugs are not particularly limited, and examples include skin care products such as lotions, emulsions, gels, creams, serums, sunscreen cosmetics, and masks; cleansing cosmetics such as shampoos, rinses, and treatments; and bath additives.

[0045] (Base or Carrier) Examples of the base or carrier include hydrocarbons such as liquid paraffin, squalane, petrolatum, gelling hydrocarbons (such as Plastibase), ozokerite, α-olefin oligomers, and light liquid paraffin (for example, 1 to 50% by mass, 5 to 30% by mass, and 8 to 20% by mass); silicone oils such as methyl polysiloxane, crosslinked methyl polysiloxane, highly polymerized methyl polysiloxane, cyclic silicone, alkyl-modified silicone, crosslinked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, crosslinked polyether-modified silicone, crosslinked alkyl polyether-modified silicone, silicone / alkyl chain co-modified polyether-modified silicone, silicone / alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, and silicone resin; higher alcohols such as cetanol, cetostearyl alcohol, stearyl alcohol, and behenyl alcohol; cholesterol, phytosterol, and the like. sterols such as hydroxystearic acid phytosteryl and the like; vegetable oils such as jojoba oil, medfoam oil, sunflower oil, grape seed oil, camellia oil, squalane, shea butter, rice germ oil, and the like; animal oils such as lanolin, orange roughy oil, squalane, horse oil, and the like; natural polymer derivatives such as ethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, cationized guar gum, and acetylated hyaluronic acid; polyvinylpyrrolidone, carboxyvinyl polymer, acrylic acid alkyl methacrylate copolymer, and the like. Synthetic polymers; natural polymers such as carrageenan, alginic acid, cellulose, guar gum, quince seed, dextran, gellan gum, and hyaluronic acid; esters such as isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythritol tetra-2-ethylhexanoate, jojoba oil, and tri(caprylic / capric acid)glyceryl; polysaccharides such as dextrin and maltodextrin; lower alcohols such as ethanol and isopropanol;Examples include glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether; polyhydric alcohols such as polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, isoprene glycol, diglycerin, and dipropylene glycol; and aqueous bases such as water. The base or carrier may be used alone or in combination with multiple types. From the viewpoint of enhancing moisturizing power and significantly demonstrating the effects of the scalp composition of the present disclosure, the scalp topical composition preferably does not substantially contain ethanol (preferably, a lower alcohol), and more preferably does not contain ethanol.

[0046] The topical scalp composition of the present disclosure may be an emulsion composition. Examples of the emulsion composition include an oil-in-water (o / w) type and a water-in-oil (w / o) type. The oil-in-water type is preferred because it provides an excellent feeling when applied to the scalp and more significantly exhibits the effects of the topical scalp composition of the present disclosure. The oil-in-water type is composed of an aqueous dispersible continuous phase and an oily dispersible discontinuous phase, and refers to a state in which oil droplets are dispersed in the aqueous phase.

[0047] (additives) Examples of the additives include antioxidants, surfactants, antiseptics or preservatives, pH adjusters, stabilizers, chelating agents, ultraviolet absorbers or ultraviolet scattering agents, irritation reducers, colorants, refreshing agents other than (C3), fragrances other than (C3), etc. One type of the additives may be used, or multiple types may be used in combination.

[0048] Examples of the surfactant include sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate; glycerin fatty acids such as glyceryl monostearate and glycerin monostearate malate; polyglycerin fatty acids such as polyglyceryl monostearate, polyglyceryl monoisostearate, and polyglyceryl diisostearate; mono Propylene glycol fatty acid esters such as propylene glycol stearate; hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), and polyoxyethylene hydrogenated castor oil 80; polyoxyethylene (20) sorbitan monolaurate (polysorbate 20), polyoxyethylene (20) sorbitan monostearate (polysorbate 60), and polyoxyethylene (20) sorbitan monooleate (polysorbate Polyoxyethylene sorbitan fatty acid esters such as bate 80 and polyoxyethylene (20) sorbitan isostearate; polyoxyethylene monoglyceryl cocoate; glycerin alkyl ethers; alkyl glucosides; alkyl glucosides; polyoxyalkylene alkyl ethers such as polyoxyethylene stearyl ether, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, and polyoxyethylene behenyl ether; amines such as stearylamine and oleylamine; silicone surfactants such as polyoxyethylene-methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone; natural surfactants such as phospholipids, surfactin, and saponin; fatty acid amidoamines such as stearic acid diethylaminoethylamide and stearic acid diethylaminopropylamide; alkylamines such as trilaurylamine, dimethylstearylamine, and di-2-ethylhexylamine; betaine-based amphoteric surfactants such as stearic acid dimethylaminopropylamide and laurylhydroxysulfobetaine;etc.;

[0049] Examples of the pH adjuster include inorganic acids such as hydrochloric acid and sulfuric acid; organic acids such as lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid and sodium succinate; inorganic bases such as potassium hydroxide and sodium hydroxide; and organic bases such as triethanolamine, diisopropanolamine and triisopropanolamine.

[0050] (Other active ingredients) The topical scalp composition of the present disclosure may contain active ingredients other than the (A), (B), and (C1) to (C4) components, as long as the effects of the topical scalp composition of the present disclosure are not impaired. Examples of the active ingredients include anti-inflammatory ingredients such as salicylic acid and its derivatives (e.g., glycol salicylate, methyl salicylate) and their salts, allantoin, antibacterial ingredients such as isopropylmethylphenol, benzalkonium chloride, and benzethonium chloride, astringent ingredients such as zinc oxide and calamine, local anesthetic ingredients such as ethyl aminobenzoate, oxypolyethoxydodecane, dibucaine, dibucaine hydrochloride, lidocaine, and lidocaine hydrochloride, local irritant ingredients such as aqueous ammonia, tocopherol acetate, tocopherol, panthenol, and vitamin A oil. and vitamins such as retinol palmitate; blood circulation promoting ingredients such as oryzanol; and hair care and growth ingredients such as piroctone olamine, carrot extract, Swertia japonica extract, seaweed extract, minoxidil, finasteride, carpronium chloride, hinokitiol, estradiol benzoate, pyridoxine hydrochloride, potassium pantothenate, resorcinol, ginseng tincture, cashew tincture, arnica tincture, dl-α-tocopherol, 2-L-ascorbic acid phosphate diester potassium salt, and 6-benzylaminopurine. The active ingredients may be used alone or in combination.

[0051] (pH) The pH of the scalp external composition of the present disclosure may be, for example, pH 2 to 9, but from the viewpoint of low irritation to the scalp and a pleasant feel on the scalp when used, the pH is preferably 3 to 8.5, and more preferably 4 to 8.

[0052] (container) The scalp topical composition of the present disclosure may be contained in, for example, a container. The container can be appropriately selected depending on the intended use, etc., and examples thereof include bottle type, tube type, jar type, dropper type, dispenser type, stick type, pouch bag, and cheer pack. The discharge port of the container can be appropriately selected depending on the intended use, etc., and specific examples thereof include drop type, pen type, sponge type, roll-on type, spray type, spatula type, brush type, pin holder type, and microneedle type. The container is preferably a container with a drop type, pen type, sponge type, or spray type discharge port, which facilitates direct contact of the scalp topical composition with the scalp, for example.

[0053] The material of the container is, for example, polyethylene terephthalate, polypropylene, polyethylene Polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin Examples of the materials include grease, polystyrene, glass, and metal (aluminum, etc.). Taking into consideration strength, flexibility, weather resistance, and component stability, the above materials can be used as container materials by applying various coating treatments, combining these materials by mixing, or laminating them. Examples of the coating material include epoxy resin and polyamideimide.

[0054] (Terms of use) The conditions for use of the topical scalp composition of the present disclosure (e.g., dosage, method of use) can be appropriately determined depending on the scalp condition, age, sex, etc. of the subject, as long as the effects of the topical scalp composition are obtained. The frequency of use is, for example, several times a day (e.g., about 1 to 5 times, preferably 1 to 3 times). The dosage is, for example, about 0.5 to 2 ml. The method of use simply involves applying the topical scalp composition to the scalp of the subject.

[0055] (Evaluation of scalp odor suppression) The "scalp odor suppression" can be performed, for example, by evaluating the odor level of the artificial leather using artificial leather, scalp odor, and artificial sweat. Specifically, the evaluation can be performed by scoring the odor level according to Example 1(3) described below.

[0056] (Evaluation of water compatibility) The compatibility with water can be evaluated, for example, by measuring the contact angle when the composition for external use on scalp is brought into contact with water on a glass surface. Specifically, the evaluation can be performed in accordance with Example 2(3) described below.

[0057] (Manufacturing method) The method for producing the topical scalp composition of the present disclosure can be, for example, by mixing (A) a heparinoid and (B) diphenhydramine and / or a salt thereof and adjusting the viscosity. If necessary, emulsification may be performed according to a conventional method.

[0058] (Application) In the scalp external composition of the present disclosure, for example, the container containing the composition may be labeled with a statement that the scalp external composition of the present disclosure has a scalp odor suppressing effect. In this case, the labeling can be a labeling that is easy for consumers to understand. The labeling is not particularly limited, and examples thereof include the following. "For those who are concerned about scalp odor" "For those who are concerned about scalp odor"

[0059] In addition, since the scalp topical composition of the present disclosure contains (A) a heparinoid and (B) diphenhydramine and its salt, based on the effects of these, it may be labeled as having the effect of moisturizing the scalp and / or suppressing itching. As with the above-mentioned labeling, the labeling can be easily understood by consumers. The labeling is not particularly limited, and examples thereof include the following: "For itchy scalp" "For dry scalp" "For dry and itchy scalp" "For itchy, dry scalp" "For dry skin symptoms accompanied by itchy scalp" "It can simultaneously relieve scalp itchiness and moisturize."

[0060] <External scalp products> In another aspect, the present disclosure provides an external scalp product. The external scalp product of the present disclosure includes the external scalp composition of the present disclosure and a container with a discharge part such as a dropper, pen, sponge, or spray, and the external scalp composition is contained in the container. The external scalp product of the present disclosure can be used in conjunction with the description of the external scalp composition of the present disclosure. The external scalp product of the present disclosure can provide an external scalp product that can suppress scalp itching and scalp odor.

[0061] The topical scalp product of the present disclosure can be prepared, for example, as a product or article containing the topical scalp composition in a container.

[0062] In the scalp topical product of the present disclosure, the container or the packaging containing the container may be labeled, as described above, to indicate that the scalp topical composition has the effect of suppressing scalp odor, and / or that it has the effect of moisturizing the scalp and / or suppressing itching.

[0063] <Method of imparting scalp odor suppression effect to an external composition> In another aspect, the present disclosure provides a method for imparting a scalp odor suppressing effect (hereinafter also referred to as an "application method"). The application method of the present disclosure includes an adjustment step of adjusting the viscosity of an external composition containing (A) a heparinoid and (B) diphenhydramine and / or a salt thereof to 140 Pa·s or less. According to the application method of the present disclosure, a scalp odor suppressing effect can be imparted to the external composition. The application method of the present disclosure can be applied to the description of the external scalp composition of the present disclosure. The application method of the present disclosure can also be referred to as, for example, a method for producing an external composition imparted with a scalp odor suppressing effect.

[0064] <Composition for suppressing scalp odor> In another aspect, the present disclosure provides a composition for suppressing scalp odor. The composition for use in suppressing scalp odor of the present disclosure contains (A) a heparinoid and (B) diphenhydramine and / or a salt thereof, and has a viscosity of 140 Pa s or less. The description of the scalp topical composition of the present disclosure can be applied to the composition for suppressing scalp odor of the present disclosure.

[0065] <How to suppress scalp odor> In another aspect, the present disclosure provides a method for suppressing scalp odor (hereinafter also referred to as the "suppression method"). The suppression method of the present disclosure uses a composition for external use on the scalp containing (A) a heparinoid and (B) diphenhydramine and / or a salt thereof, and having a viscosity of 140 Pa·s or less. The suppression method of the present disclosure is characterized by using the composition for external use on the scalp of the present disclosure, and other steps and conditions are not particularly limited. The suppression method of the present disclosure can suppress scalp odor. The suppression method of the present disclosure can be applied to the description of the composition for external use on the scalp of the present disclosure.

[0066] <Use> The present disclosure relates to the use of a scalp external composition for use in suppressing scalp odor. For example, the present disclosure can be incorporated by reference in the description of the scalp external composition and the scalp odor suppression method of the present disclosure. [Example]

[0067] Next, examples of the present disclosure will be described, but the present disclosure is not limited to the following examples. Commercially available reagents were used according to their protocols unless otherwise specified.

[0068] [Example 1] A scalp external composition according to the present disclosure was prepared, and its effect of suppressing scalp odor was confirmed.

[0069] (1) Preparation of a composition for topical application to the scalp Compositions of Examples 1-1 to 1-6 (topical scalp compositions of the present disclosure) and the composition of Comparative Example 1-1 were prepared by combining the various components and compositions shown in Table 1. The compositions of Examples 1-1 to 1-6 and the composition of Comparative Example 1-1 were all oil-in-water emulsion preparations.

[0070] (2) Viscosity measurement The viscosity of each composition obtained in Example 1(1) was measured. Specifically, 50 g of each composition was filled into a 50 ml vial, and the temperature was set to 25°C. Thereafter, the viscosity was measured at 0.6 rpm using a TVB-15 viscometer (M4 rotor, manufactured by Toki Sangyo Co., Ltd.). Table 1 below shows the viscosity measurement results for the compositions of Examples 1-1 to 1-6 and the composition of Comparative Example 1-1.

[0071] (3) Examination of the effect of suppressing scalp odor The scalp external composition of the present disclosure was examined to determine whether it exhibited a scalp odor suppression effect. Specifically, 80 μl of scalp odor artificial sweat (acidic) (see Japanese Industrial Standards (JIS) L0848) was dropped onto an approximately 4 cm × 3 cm piece of artificial leather and applied to every corner. After the application, 0.2 g of the compositions of Examples 1-1 to 1-6 prepared in Example 1(1) or the composition of Comparative Example 1-1 was applied. After the application, the artificial leather was placed in a 140 × 100 mm Ziploc® bag and left for 30 minutes. A scalp odor sensory test was then conducted. In the sensory test, subjects (five individuals who regularly evaluate body odor when evaluating external preparations) smelled the odor in the Ziploc® bag, and the degree of scalp odor suppression was evaluated using the Visual Analogue Scale (VAS). Specifically, on a subjective symptom survey sheet with a 10 cm line drawn, the subject marked the distance (cm) where the scalp odor was significantly perceived as 0 cm, and the scalp odor was completely absent as 10 cm. The length (cm) checked by the subject was used as the VAS value. Based on the VAS value, evaluation was performed according to the following evaluation criteria. As the evaluation standard sample, a mixture of scalp odor and a formulation (the formulation of the example) in a specific ratio was used, and the evaluation was performed with a score of 5 when the VAS value of the evaluation standard sample was 5 cm. These results are shown in Table 1 below. <Scalp odor evaluation criteria> 6.0 and above:++ 4.0 or higher and less than 6.0: + Below 4.0:-

[0072] [Table 1]

[0073] As shown in Table 1, the compositions of Examples 1-1 to 1-6 containing the same components and having a viscosity of 140 Pa s or less were found to be more effective in suppressing scalp odor than the composition of Comparative Example 1-1 containing a heparinoid and diphenhydramine and having a viscosity of 173 Pa s. It was also found that scalp odor could be effectively suppressed by further adding glycyrrhetinic acid or l-menthol.

[0074] Furthermore, when four subjects suffering from dry and itchy scalp symptoms applied the scalp external compositions of Examples 1-1 to 1-6 to their scalps, it was confirmed that the dry and itchy symptoms were suppressed.

[0075] [Example 2] A scalp topical composition according to the present disclosure was prepared and its compatibility with water was confirmed.

[0076] (1) Preparation of a composition for topical application to the scalp Compositions of Examples 2-1 to 2-6 (topical scalp compositions of the present disclosure) and the composition of Comparative Example 2-1 were prepared by combining the various components and compositions shown in Table 2. The compositions of Examples 2-1 to 2-6 and the composition of Comparative Example 2-1 were all oil-in-water emulsion preparations.

[0077] (2) Viscosity measurement The viscosity of each composition obtained in Example 2(1) was measured in the same manner as in Example 1(2). Table 2 below shows the viscosity measurement results for the compositions of Examples 2-1 to 2-6 and the composition of Comparative Example 2-1.

[0078] (3) Examination of compatibility with water The compatibility of the topical scalp composition of the present disclosure with water was examined. Specifically, 0.1 g of each of the compositions of Examples 2-1 to 2-6 prepared in Example 2(1) above or the composition of Comparative Example 2-1 was applied to a glass slide. After application, 1 μl of water was dropped onto the glass slide using a syringe attached to a contact angle meter (Drop Master 500, manufactured by Kyowa Interface Science Co., Ltd.). 300 milliseconds after the drop, the contact angle was measured. The contact angle was measured using an interFAce Measurement & Analysis System (manufactured by Kyowa Interface Science Co., Ltd.). Based on the contact angle values ​​obtained in the measurement, evaluation was performed according to the following evaluation criteria. The results are shown in Table 2 below. <Evaluation criteria for familiarity> Below 20 degrees:++ Below 40 degrees:+ Over 40 degrees:-

[0079] [Table 2]

[0080] As shown in Table 2, the composition of Comparative Example 2-1 had a contact angle of 40 degrees or more, indicating poor compatibility with water. On the other hand, the compositions of Examples 2-1 to 2-6 showed reduced contact angles and improved compatibility with water, and it was found that the contact angle could be further reduced and compatibility with water could be further improved, particularly at a viscosity of 110 Pa·s or less. These results suggest that the topical scalp composition of the present disclosure is compatible with sweat and water and can be easily used on a sweaty scalp or after washing the hair.

[0081] (Formulation example) The scalp topical compositions of the present disclosure prepared based on the formulations in Tables 3 and 4 below were filled into polyethylene containers in amounts of 30 ml each, and a dropper nozzle was attached to obtain Formulation Examples 1 to 21. Formulation Examples 1 to 11 are solubilized formulations, and Formulation Examples 12 to 21 are oil-in-water emulsion formulations.

[0082] [Table 3]

[0083] [Table 4]

[0084] Although the present disclosure has been described above with reference to embodiments and examples, the present disclosure is not limited to the above embodiments and examples. Various modifications that can be understood by a person skilled in the art can be made to the configuration and details of the present disclosure within the scope of the present disclosure.

[0085] <Additional Notes> Some or all of the above-described embodiments and examples can be described as, but are not limited to, the following supplementary notes. <Scalp external composition> (Appendix 1) (A) a heparinoid; (B) diphenhydramine and / or a salt thereof; Contains A composition for external application to the scalp, having a viscosity of 140 Pa·s or less. (Appendix 2) A composition for external use on the scalp described in Appendix 1, which is an emulsion composition. (Appendix 3) The scalp topical composition described in Appendix 2, wherein the emulsion composition is an oil-in-water type. (Appendix 4) moreover, (C1) Crotamiton; (C2) Pantothenic acid, its derivatives, and their salts; (C3) terpenoids; (C4) Glycyrrhizic acids; A composition for external use on the scalp described in any one of Appendix 1 to 3, containing one or more selected from the group consisting of: (Appendix 5) A scalp topical composition described in any one of Appendices 1 to 4, wherein the viscosity is measured using a B-type viscometer at a temperature of 25°C and a rotation speed of 0.6 rpm. <External scalp products> (Appendix 6) A scalp external product comprising a scalp external composition described in any one of Appendices 1 to 5 contained in a container having a drop-type, pen-type, sponge-type, or spray-type discharge part. <Method of imparting scalp odor suppressing effect to a topical composition> (Appendix 7) (A) a heparinoid; (B) diphenhydramine and / or a salt thereof; A method for imparting a scalp odor suppressing effect to an external composition containing the compound, characterized in that the viscosity of the external composition is set to 140 Pa·s or less. <Use> (Appendix 8) Use of a scalp external composition described in any one of Appendices 1 to 6 for suppressing scalp odor. [Industrial Applicability]

[0086] As described above, the present disclosure provides a scalp topical composition that can suppress scalp odor while suppressing scalp itching. Therefore, the present disclosure can be said to be extremely useful in the fields of cosmetics, topical skin preparations, etc.

Claims

1. (A) a heparinoid; (B) diphenhydramine and / or a salt thereof; Contains A composition for external use on the scalp, having a viscosity of 140 Pa·s or less.

2. The composition for external application to the scalp according to claim 1, which is an emulsion composition.

3. The scalp topical composition according to claim 2, wherein the emulsion composition is an oil-in-water type.

4. moreover, (C1) crotamiton; (C2) pantothenic acid, its derivatives, and salts thereof; (C3) terpenoids; (C4) glycyrrhizic acids; The scalp external composition according to claim 1 or 2, comprising one or more selected from the group consisting of:

5. The scalp external composition according to claim 1 or 2, a container having a dropper-type, pen-type, sponge-type, or spray-type discharge part; The scalp external product is the scalp external composition contained in the container.

6. (A) a heparinoid; (B) diphenhydramine and / or a salt thereof; In a topical composition containing A method for imparting scalp odor suppressing properties to an external composition, comprising an adjusting step of adjusting the viscosity to 140 Pa·s or less.

Images