Distal airway and alveolar model
Patent Information
- Application Number
- JP2025501889
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-07-15
- Filing Date
- 2023-07-10
- Publication Date
- 2026-07-21
AI Technical Summary
Current models fail to accurately simulate the interaction between inhalable agents and the distal airways and alveoli, lacking the ability to reproduce physiologically relevant conditions and deposition patterns, and are not designed to hold cell cultures for in vitro exposure.
A rigid porous foam with an open-cell hierarchical network of macropores and micropores/nanopores is used to simulate the distal airways and alveoli, providing a stable and reproducible model that mimics the anatomical and physiological characteristics of the respiratory tract, including a large, moist surface and optimal flow rates.
The model enhances the accuracy and reliability of in vitro methods for inhaled toxicity testing and preclinical evaluation of inhalable agents, allowing for precise simulation of gas exchange and deposition patterns, improving translatability from in vitro to in vivo studies.