Enzymatic modification of saponins
JP2025525334A5Pending Publication Date: 2026-06-22GLAXOSMITHKLINE BIOLOGICALS SA
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Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- GLAXOSMITHKLINE BIOLOGICALS SA
- Filing Date
- 2023-06-13
- Publication Date
- 2026-06-22
AI Technical Summary
Technical Problem
Current methods for producing saponins from plant cell cultures face challenges in yield and separation of specific saponins from other components, leading to a need for improved methods to enhance production and facilitate the removal of undesired saponin components.
Method used
The method involves culturing plant cells capable of synthesizing saponins, recovering saponins, and enzymatically converting starting saponins into product saponins using modified glucosidases and rhamnosidases to increase yield and purity.
Benefits of technology
This approach enhances the production of target saponins and facilitates the removal of undesired components, resulting in higher yields and purer saponin products suitable for adjuvant compositions.
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Abstract
The present invention relates to a method for enzymatically modifying saponin produced in plant cell culture, a product produced thereby, uses of the product, and other related aspects. The saponin can be obtained from a plant cell culture extract of Quillaja species, such as an extract of Quillaja Saponaria Molina.
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