Enzymatic modification of saponins

JP2025525334A5Pending Publication Date: 2026-06-22GLAXOSMITHKLINE BIOLOGICALS SA
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Patent Information

Application Number
JP2024573495
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-06-15
Filing Date
2023-06-13
Publication Date
2026-06-22

AI Technical Summary

Technical Problem

Current methods for producing saponins from plant cell cultures face challenges in yield and separation of specific saponins from other components, leading to a need for improved methods to enhance production and facilitate the removal of undesired saponin components.

Method used

The method involves culturing plant cells capable of synthesizing saponins, recovering saponins, and enzymatically converting starting saponins into product saponins using modified glucosidases and rhamnosidases to increase yield and purity.

Benefits of technology

This approach enhances the production of target saponins and facilitates the removal of undesired components, resulting in higher yields and purer saponin products suitable for adjuvant compositions.

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Abstract

The present invention relates to a method for enzymatically modifying saponin produced in plant cell culture, a product produced thereby, uses of the product, and other related aspects. The saponin can be obtained from a plant cell culture extract of Quillaja species, such as an extract of Quillaja Saponaria Molina.
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