β-lactam compounds, their use, and methods for their preparation.
Novel β-lactam compounds effectively address the limitations of aztreonam derivatives by providing strong antibacterial activity against Gram-negative bacteria with minimal drug resistance through specific synthesis methods.
JP7876847B2Inactive Publication Date: 2026-06-22GUANGZHOU HC PHARM CO LTD
Patent Information
- Application Number
- JP2022574453
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2020-06-02
- Filing Date
- 2021-04-30
- Publication Date
- 2026-06-22
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Technical Problem
Current antibacterial agents, particularly aztreonam derivatives, exhibit insufficient antibacterial activity against Gram-negative bacteria and have issues with drug resistance.
Method used
Development of novel β-lactam compounds represented by general formulas (I) and (I-1) to (I-2), which are synthesized through specific chemical reactions involving protecting groups and subsequent removal, ensuring effective antibacterial activity against Gram-negative bacteria with negligible drug resistance.
Benefits of technology
The compounds demonstrate excellent antibacterial activity against Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa while showing negligible drug resistance.
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Abstract
The present invention relates to a compound represented by the following general formula (I): R1 and R2 each independently represent a hydrogen atom or an optionally substituted C1-10 linear or branched alkyl, or R1 and R2 together form a cycloalkyl having 3 to 8 ring carbon atoms; R3 and R4 each independently represent a hydrogen atom or an optionally substituted C1-10 linear or branched alkyl, or an optionally substituted C6-12 aryl; or R3 and R4 together form a cycloalkyl having 3 to 8 ring carbon atoms; X represents C or N; and Y represents an optionally substituted linear or branched alkenyl or alkynyl having 2 to 6 carbon atoms, or carboxyl. The compound has good antibacterial activity against bacteria, particularly gram-negative bacteria, low drug resistance, and good prospects for effective treatment of various pathologies. [Formula 1] TIFF2023527917000064.tif58170
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Citation Information
Patent Citations
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