Bupropion for modulating drug plasma levels of dextrometorphan

Abstract

Bupropion for use in a method for increasing plasma levels of dextromethorphan in a human subject who is an extensive metabolizer of dextromethorphan and in need of dextromethorphan treatment, wherein the use comprises daily co-administration of bupropion with dextromethorphan to the human subject for at least eight consecutive days and wherein, on the eighth day of co-administration of bupropion with dextromethorphan, the AUC0-12 of dextromethorphan is at least 400 ng·h / ml. The application contains 14 additional claims.