Nanoemulgel for teeth whitening

Abstract

OCR09WP27 / 04 / 2569 The nanoemulgel product for teeth whitening in this invention contains solid dispersion. Solid dispersions of carbamide peroxide encapsulated in a nanoemulsion. 1-65% by weight and hydrogel 35-99% by weight, where nanoemulsion is present. It consists of a solid dispersion of carbamide peroxide, water, and a surfactant, which is processed... The preparation of nanoemulgel products for teeth whitening was done by passing the mixture through a high-speed grinding machine. High pressure is used to obtain small internal particles at the nanometer level. Once the nanoemulsion is obtained, it is dispersed in... The hydrogel will yield a nanoemulgel product for teeth whitening when its whitening efficacy is tested. The teeth were found to provide good whitening results.

Claims

OCR09WP27 / 04 / 25691. A nanoemulsion gel product for teeth whitening consisting of: - A nanoemulsion composed of a solid dispersion of carbamide peroxide, water, and a surfactant, where the solid dispersion of carbamide peroxide consists of carbamide peroxide and a carrier agent in a ratio of 1:0.2-5 by weight, at a concentration of 1-65 by weight. - A hydrogel at a concentration of 35-99 by weight.

2. A nanoemulsion gel product for teeth whitening according to claim 1, in which the carrier agent consists of:

2. The first substance is 1-ethynylpyrrolidin-2-one with a molecular weight of 2,000-5,000,000 or other polymer compounds containing 1-ethynylpyrrolidin-2-one, and the second substance is 1,1,2-Trimethyl-1H-benzo[e]indole.

3. A teeth whitening nanoemulsion product according to claim 1 or 2, in which the nanoemulsion consists of a solid dispersion of carbamide peroxide, water, and surfactant in a ratio of 1-6.5:1-3:0.5-1 by weight. 4.

5. Nanoemulsion gel teeth whitening products under any of the patents 1-3, which are additionally formulated with fluoride, silica, and natural extracts, including formulation aids such as thickeners, antioxidants, preservatives, flavorings, colorings, and fragrances, or a mixture of these, in amounts of 0.1-5% by weight.

6. Nanoemulsion gel teeth whitening products under any of the patents 1-4, where the surfactant is selectable from polyoxymethylene sorbitan fatty acid esters or a mixture of polyoxymethylene sorbitan fatty acid esters and sorbitan esters.

7. The preparation method for the nanoemulgel teeth whitening product under any of the patents 1 through 5, in which a hydrogel of choice is obtained from sodium carboxymethyl starch mixed with 1-ethinylperolidine-2-one or carbopol, poloxamer, hydroxypropylmethylcellulose, cellulose compounds, natural gelling agent, or synthetic gelling agent, or a mixture of natural and synthetic gelling agents, dissolved in water, glycerin, propylene glycol, polyethylene glycol, or a solution classified as a polar solvent or capable of dissolving polar solvents, or dissolved in a mixed solution of the aforementioned solvents.The solid dispersion of carbamide peroxide is prepared by mixing carbamide peroxide in an organic ethyl alcohol solution. The first carrier is 1-ethenylperrolidine-2-one mixed in the ethyl alcohol solution, and the second carrier is 1,1,2-trimethylbenzoindole mixed in the dichloromethane solution. The carbamide peroxide and both carriers are mixed in a ratio of 1:0.2-5 by weight and stirred until the solution is clear and homogeneous. a. The solid dispersion of carbamide peroxide is then subjected to vacuum evaporation while maintaining a controlled temperature of 40-80 degrees Celsius to obtain it. b. The solid dispersion of carbamide peroxide is then used to prepare a nanoemulsion from step a. It is mixed with a ratio of solid dispersion, water, and surfactant of 1-6.5:1-3:0.5-1 by weight. The mixture is stirred at high speed to obtain nanoparticles, and the temperature during mixing is controlled to be between 40-60 degrees Celsius. c.A hydrogel composed of sodium carboxymethyl starch and 1-ethinylperrolidine-2-one was prepared by mixing sodium carboxymethyl starch with water in a ratio of 1:2-4 by weight. This mixture was then heated to 50-100°C and mixed until a homogeneous mixture was obtained. After cooling to room temperature, 1-ethinylperrolidine-2-one and water were mixed in a ratio of 1:4-10 by weight, and a homogeneous mixture was obtained. The sodium carboxymethyl starch hydrogel and the 1-ethinylperrolidine-2-one hydrogel were then mixed in a ratio of 1:0.2-5 by weight until a homogeneous hydrogel was obtained. Finally, 1-65% by weight of the nanoemulsion obtained in step b was mixed with 35-99% by weight of the hydrogel prepared in step c to obtain a teeth whitening nanoemulsion gel product.