Viscosity-adjustable hydrogel material, and preparation method therefor and use thereof

Abstract

Provided in the present application are a viscosity-adjustable hydrogel material, and a preparation method therefor and the use thereof. The preparation raw materials of the viscosity-adjustable hydrogel material comprise the following components in parts by weight: 10-30 parts of a monomer, 1-20 parts of a cross-linking agent, 0.1-5 parts of a long-chain polymer, 0.01-5 parts of dopamine hydrochloride, 0.01-5 parts of clay and 50-90 parts of water. By means of selection of chemical components and regulation of the amounts thereof, the viscosity-adjustable hydrogel material provided in the present application can easily realize the compatibility and regulation of surface adhesive and non-adhesive properties of the hydrogel material, and also has an anti-freezing moisture retention property, a self-healing property, biocompatibility, flexibility and elasticity, such that same can be applied to biomedical materials or flexible electronic devices.

Description

A viscosity-adjustable hydrogel material and its preparation method and application Technical Field

[0001] The present application belongs to the technical field of self-repairing materials, and specifically relates to a viscosity-adjustable hydrogel material and its preparation method and application. Background Art

[0002] Hydrogel is a hydrophilic polymer with a three-dimensional network structure synthesized from natural or synthetic materials. Due to the presence of hydrophilic groups such as -NH2, -COOH, and -OH, hydrogen bonds can be formed with water molecules within the hydrogel network, allowing the hydrogel to absorb and retain large amounts of water. Hydrogels are not only highly flexible but also have a soft rubber consistency similar to living tissue, making them ideal substances or carriers for various applications. By modifying and optimizing the original properties of hydrogels or by compounding them to give them new excellent properties, such as good biocompatibility, degradability, and antibacterial and anti-inflammatory properties, and by making their physical properties, chemical properties, and structure easy to control, major breakthroughs have been achieved in many aspects such as biomedical materials and flexible electronic devices, and they have attractive application prospects.

[0003] Hydrogels are gel materials formed through physical or chemical crosslinking. Different crosslinking methods and matrix materials can give hydrogels adjustable physical and chemical properties. The large amount of water packed into their three-dimensional network structure helps maintain good affinity between the hydrogel and the organism. In the field of biomedical materials, when hydrogels are used in the human body, in addition to their inherent abilities to promote wound healing, reduce inflammation, and exert therapeutic effects on diseases such as tumors, they can also serve as carriers for proteins, nucleic acids, and small molecule drugs. As intelligent drug delivery systems, they can achieve controlled release of substances within the human body, addressing the problem of drug susceptibility to enzymatic or hydrolytic degradation and thus improving drug delivery stability.

[0004] Polymers contain abundant reactive groups, providing ample room for molecular modification and engineering to design and construct three-dimensional cross-linked networks. These materials exhibit mechanical properties that conform to human tissue, enhanced conductivity and sensitivity, self-adhesion, self-healing properties, and 3D printability, meeting the multifunctional integration and device processing requirements of flexible sensing materials. Biocompatible hydrogels allow electronic devices to directly contact human skin and even be safely implanted in the body for extended periods of time, with minimal inflammatory or immune responses to host tissue. In flexible electronic devices, the inherent weight and flexibility of hydrogels can alleviate the discomfort associated with long-term wear or implantation of external devices, enabling continuous and long-term monitoring for healthcare sensing applications, meeting the fundamental requirement for continuous and long-term monitoring in next-generation intelligent monitoring systems. Furthermore, biodegradable and renewable natural materials can ultimately return to nature after their service life, avoiding the environmental impact of electronic waste accumulation caused by the widespread use of flexible electronics.

[0005] As a new functional material, hydrogels possess high water absorption and retention, biocompatibility, and flexibility. Through the selection, modification, and compounding of different materials, they can be endowed with specific properties. Therefore, hydrogels and their derivatives have high research value and are increasingly being used in various fields.

[0006] CN115286731A discloses an external light-curing medical hydrogel and its preparation method. The medical hydrogel is obtained by subjecting a pre-gel light-curing solution to ultraviolet light curing reaction. CN110240712A discloses a high-stretch, high-viscosity, self-healing double-network hydrogel for tissue adhesion, its preparation method, and application. These hydrogels are only viscous and cannot achieve adjustable and coexistent adhesive and non-adhesive properties. They also have poor biocompatibility.

[0007] In existing technologies, hydrogel materials exist in only one state: sticky or non-sticky, and cannot be adjusted. This fails to achieve the ability to adjust and coexist both sticky and non-sticky properties within the same hydrogel material, limiting its application. Furthermore, hydrogels freeze when used below 0°C and cannot be restored after thawing due to dehydration. Furthermore, hydrogels have poor biocompatibility. Therefore, developing a hydrogel material with adjustable and coexistent sticky and non-sticky properties, antifreeze and moisture retention, self-healing properties, biocompatibility, and elasticity for use in biomedical materials and flexible electronic devices is a non-negligible challenge.

[0008] Summary of the Invention

[0009] The present application provides a viscosity-adjustable hydrogel material, its preparation method and application, which achieves the characteristics of adjustable and coexistent viscosity and non-viscosity by regulating with different chemical components, and at the same time has antifreeze and moisture retention, self-healing, biocompatibility and flexibility.

[0010] In a first aspect, the present application provides a viscosity-adjustable hydrogel material, wherein the raw materials for preparing the viscosity-adjustable hydrogel material include the following components in parts by weight: 10 to 30 parts by weight of a monomer, 1 to 20 parts by weight of a cross-linking agent, 0.1 to 5 parts by weight of a long-chain polymer, 0.01 to 5 parts by weight of dopamine hydrochloride, 0.01 to 5 parts by weight of clay, and 50 to 90 parts by weight of water.

[0011] The viscosity-adjustable hydrogel material provided in the present application is an interpenetrating network flexible elastic hydrogel material, which forms a gel through the reaction of monomers and cross-linking agents. The long-chain polymers can improve the overall flexibility and viscosity of the hydrogel material in the form of an interpenetrating network; dopamine hydrochloride can self-polymerize into polydopamine, which can also improve the overall viscosity of the hydrogel material and increase the self-healing performance in the form of an interpenetrating network; the strength of the hydrogel material can be improved by clay; through the selection and dosage control of chemical components, the viscosity-adjustable hydrogel material provided in the present application can achieve the control of sticky and non-sticky properties, that is, to obtain a sticky hydrogel material or a non-sticky hydrogel material. By covering the surface of the sticky hydrogel material with a layer of non-sticky hydrogel material, a hydrogel material with sticky one side and non-sticky the other side can be obtained, which can achieve the compatibility and coexistence of sticky and non-sticky hydrogel materials.

[0012] In the preparation raw materials of the viscosity-adjustable hydrogel material, the added amount of the monomer can be 10 to 30 parts by weight, for example, it can be 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight, 20 parts by weight, 22 parts by weight, 24 parts by weight, 26 parts by weight, 28 parts by weight or 30 parts by weight, as well as specific values ​​between the above points. Due to space limitations and for the sake of simplicity, this application no longer exhaustively lists the specific points included in the range.

[0013] The amount of the cross-linking agent added can be 1 to 20 parts by weight, for example, 1 part by weight, 2 parts by weight, 4 parts by weight, 6 parts by weight, 8 parts by weight, 10 parts by weight, 12 parts by weight, 14 parts by weight, 16 parts by weight, 18 parts by weight or 20 parts by weight, as well as specific values ​​between the above points. Due to space limitations and for the sake of simplicity, this application no longer exhaustively lists the specific points included in the range.

[0014] The addition amount of the long-chain polymer can be 0.1 to 5 parts by weight, for example, it can be 0.1 parts by weight, 0.5 parts by weight, 1 part by weight, 1.5 parts by weight, 2 parts by weight, 2.5 parts by weight, 3 parts by weight, 3.5 parts by weight, 4 parts by weight, 4.5 parts by weight or 5 parts by weight, as well as specific values ​​between the above points. Due to space limitations and for the sake of simplicity, this application no longer exhaustively lists the specific points included in the range.

[0015] The addition amount of the dopamine hydrochloride can be 0.01 to 5 parts by weight, for example, it can be 0.01 parts by weight, 0.05 parts by weight, 0.1 parts by weight, 0.5 parts by weight, 1 part by weight, 1.5 parts by weight, 2 parts by weight, 2.5 parts by weight, 3 parts by weight, 3.5 parts by weight, 4 parts by weight, 4.5 parts by weight or 5 parts by weight, as well as specific values ​​between the above points. Due to space limitations and for the sake of brevity, this application no longer exhaustively lists the specific points included in the range.

[0016] The amount of the clay added can be 0.01 to 5 parts by weight, for example, 0.01 parts by weight, 0.05 parts by weight, 0.1 parts by weight, 0.5 parts by weight, 1 part by weight, 1.5 parts by weight, 2 parts by weight, 2.5 parts by weight, 3 parts by weight, 3.5 parts by weight, 4 parts by weight, 4.5 parts by weight or 5 parts by weight, as well as specific values ​​between the above points. Due to space limitations and for the sake of brevity, this application no longer exhaustively lists the specific points included in the range.

[0017] The amount of water added can be 50 to 90 parts by weight, for example, 50 parts by weight, 55 parts by weight, 60 parts by weight, 65 parts by weight, 70 parts by weight, 75 parts by weight, 80 parts by weight, 85 parts by weight or 90 parts by weight, as well as specific values ​​between the above points. Due to space limitations and for the sake of simplicity, this application no longer exhaustively lists the specific points included in the range.

[0018] The following are preferred technical solutions of this application, but are not intended to limit the technical solutions provided in this application. Through the following preferred technical solutions, the objectives and beneficial effects of this application can be better achieved and realized.

[0019] As a preferred technical solution, the monomer includes any one of acrylamide, methacrylamide or hydroxyethyl methacrylate, or a combination of at least two of them.

[0020] Preferably, the monomer comprises acrylamide.

[0021] As a preferred technical solution, the cross-linking agent includes polyethylene glycol diacrylate and / or N,N'-methylenebisacrylamide.

[0022] Preferably, the cross-linking agent comprises polyethylene glycol diacrylate.

[0023] Preferably, the number average molecular weight of the polyethylene glycol diacrylate is 600-1000.

[0024] As a preferred technical solution, the long-chain polymer includes polyethylene oxide and / or hydroxyethyl cellulose.

[0025] Preferably, the average molecular weight of the polyethylene oxide is 100,000 to 8,000,000, for example, it can be 100,000, 500,000, 1,000,000, 1,500,000, 2,000,000, 2,500,000, 3,000,000, 3,500,000, 4,000,000, 5,000,000, 6,000,000, 7,000,000 or 8,000,000, as well as specific values ​​between the above points. Due to space limitations and for the sake of brevity, this application no longer exhaustively lists the specific points included in the range.

[0026] Preferably, the viscosity of the hydroxyethyl cellulose is 100 to 6400 mPa.s, for example, it can be 100 mPa.s, 500 mPa.s, 1000 mPa.s, 1500 mPa.s, 2000 mPa.s, 3000 mPa.s, 4000 mPa.s, 5000 mPa.s, 6000 mPa.s or 6400 mPa.s, as well as specific point values ​​between the above point values. Due to space limitations and for the sake of simplicity, this application no longer exhaustively lists the specific point values ​​included in the range.

[0027] As a preferred technical solution, the clay includes any one or a combination of at least two of lithium magnesium silicate, carbon fibers, silver nanoparticles, silicon dioxide nanoparticles or graphene oxide.

[0028] Preferably, the particle size of the silver nanoparticles is 10 to 100 nm, for example, 10 nm, 20 nm, 30 nm, 40 nm, 50 nm, 60 nm, 70 nm, 80 nm, 90 nm or 100 nm, as well as specific values ​​between the above points. Due to space limitations and for the sake of brevity, this application no longer exhaustively lists the specific points included in the range.

[0029] Preferably, the particle size of the silica nanoparticles is 10 to 500 nm, for example, it can be 10 nm, 50 nm, 100 nm, 150 nm, 200 nm, 250 nm, 300 nm, 350 nm, 400 nm, 450 nm or 500 nm, as well as specific point values ​​between the above point values. Due to space limitations and for the sake of simplicity, this application no longer exhaustively lists the specific point values ​​included in the range.

[0030] As a preferred technical solution, the raw materials for preparing the viscosity-adjustable hydrogel material also include 10 to 50 parts by weight of a moisturizer, for example, 10 parts by weight, 15 parts by weight, 20 parts by weight, 25 parts by weight, 30 parts by weight, 35 parts by weight, 40 parts by weight, 45 parts by weight or 50 parts by weight, as well as specific values ​​between the above points. Due to space limitations and for the sake of simplicity, this application no longer exhaustively lists the specific points included in the range.

[0031] Preferably, the humectant includes a polyol. The present application imparts antifreeze and moisturizing properties to the hydrogel material through the humectant.

[0032] Preferably, the polyol comprises glycerol and / or ethylene glycol.

[0033] As a preferred technical solution, the raw materials for preparing the viscosity-adjustable hydrogel material also include 0.2 to 2 parts by weight of an initiator, for example, 0.2 parts by weight, 0.4 parts by weight, 0.6 parts by weight, 0.8 parts by weight, 1 part by weight, 1.2 parts by weight, 1.4 parts by weight, 1.6 parts by weight, 1.8 parts by weight or 2 parts by weight, as well as specific values ​​between the above points. Due to space limitations and for the sake of simplicity, this application no longer exhaustively lists the specific points included in the range.

[0034] Preferably, the initiator includes any one of a photoinitiator and a thermal initiator, and a photoinitiator is more preferred.

[0035] Preferably, the photoinitiator comprises 2-hydroxy-2-methyl-1-phenyl-1-propanone and / or 2,4,6 (trimethylbenzoyl) diphenylphosphine oxide.

[0036] The viscosity-adjustable hydrogel material provided in the present application can initiate polymerization in different ways by selecting an initiator. For example, a photoinitiator can initiate polymerization by ultraviolet light irradiation, and a thermal initiator can initiate polymerization by heating.

[0037] In a second aspect, the present application provides a method for preparing the viscosity-adjustable hydrogel material as described in the first aspect, the preparation method comprising the following steps:

[0038] The monomer, the cross-linking agent, the long-chain polymer, the dopamine hydrochloride, the clay and the water are mixed to obtain a hydrogel solution precursor; the hydrogel solution precursor is reacted in the presence of an initiator to obtain the hydrogel material.

[0039] As a preferred technical solution, the mixed material also includes a moisturizer.

[0040] Preferably, the mixing temperature is 25-60°C, for example, it can be 25°C, 30°C, 35°C, 40°C, 45°C, 50°C, 55°C or 60°C, as well as specific point values ​​between the above point values. Due to space limitations and for the sake of simplicity, this application no longer exhaustively lists the specific point values ​​included in the range.

[0041] Preferably, the initiator is a photoinitiator, and the reaction is carried out under ultraviolet light.

[0042] Preferably, the reaction time is 1 to 5 minutes, for example, it can be 1 minute, 1.5 minutes, 2 minutes, 2.5 minutes, 3 minutes, 3.5 minutes, 4 minutes or 5 minutes, as well as specific point values ​​between the above point values. Due to space limitations and for the sake of simplicity, this application no longer exhaustively lists the specific point values ​​included in the range.

[0043] Preferably, the reaction temperature is 18-35°C, for example, it can be 18°C, 19°C, 20°C, 21°C, 22°C, 23°C, 24°C, 25°C, 26°C, 28°C, 30°C, 32°C, 34°C or 35°C, as well as specific point values ​​between the above point values. Due to space limitations and for the sake of simplicity, this application no longer exhaustively lists the specific point values ​​included in the range.

[0044] As a preferred technical solution, the preparation method specifically comprises the following steps:

[0045] (1) mixing monomers, a cross-linking agent, a long-chain polymer, dopamine hydrochloride, a moisturizing agent, clay, and water to obtain a hydrogel solution precursor;

[0046] (2) adding a photoinitiator to the hydrogel solution precursor obtained in step (1) to obtain a reaction system; and

[0047] (3) The reaction system obtained in step (2) is reacted under ultraviolet light to obtain the hydrogel material.

[0048] In a third aspect, the present application provides an application of the viscosity-adjustable hydrogel material as described in the first aspect in biomedical materials or flexible electronic devices.

[0049] Compared with the prior art, this application has the following beneficial effects:

[0050] The viscosity-adjustable hydrogel material provided in this application can easily achieve the compatibility and regulation of both sticky and non-sticky properties on the surface of the hydrogel material through the selection of chemical components and the regulation of dosage. It also has antifreeze and moisture retention, self-healing properties, biocompatibility, and flexibility. This application designs and optimizes the raw materials for preparing the viscosity-adjustable hydrogel. After the viscosity-adjustable hydrogel material is cut and left to stand for 48 hours, it can achieve self-healing. The adhesion of the viscosity hydrogel material can be as high as 60N / m. After being frozen at -18℃ for 24 hours, there is no ice on the surface, showing good antifreeze properties. After standing at room temperature for 7 days, the mass reduction rate is as low as 3.8%, showing good moisture retention. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] FIG1 is a photograph of the self-healing performance test of the viscosity-adjustable hydrogel material provided in Example 3.

[0052] FIG2 is a photograph showing the self-healing performance test of the hydrogel material provided in Comparative Example 1.

[0053] FIG3 is a photograph of the viscoelastic tensile test of the viscosity-adjustable hydrogel material provided in Example 1.

[0054] FIG4 is a comparative diagram of the adhesion of the viscosity-adjustable hydrogel materials provided in Example 1 and Example 2.

[0055] FIG5 is a bar graph showing the biocompatibility test of the viscosity-adjustable hydrogel material provided in Example 1. DETAILED DESCRIPTION

[0056] The technical solution of the present application will be further described below with reference to the accompanying drawings and through specific implementation methods. Those skilled in the art should understand that the embodiments are only for the purpose of helping to understand the present application and should not be regarded as specific limitations of the present application.

[0057] The sources of some components in the following examples and comparative examples are as follows:

[0058] (1) Polyethylene glycol diacrylate: number average molecular weight 1000, purchased from Aladdin Chemical Reagent;

[0059] (2) Polyethylene oxide: average molecular weight 1,000,000, purchased from Hefei BASF Biotechnology Co., Ltd.

[0060] Example 1

[0061] A viscosity-adjustable hydrogel material. The raw materials for preparing the viscosity-adjustable hydrogel material include the following components in parts by weight: 20 parts by weight of acrylamide, 1 part by weight of polyethylene glycol diacrylate, 3 parts by weight of polyethylene oxide, 2 parts by weight of dopamine hydrochloride, 50 parts by weight of glycerol, 0.01 part by weight of lithium magnesium silicate, 50 parts by weight of water, and 0.2 part by weight of 2-hydroxy-2-methyl-1-phenyl-1-propanone.

[0062] A method for preparing a viscosity-adjustable hydrogel material, comprising the following steps:

[0063] (1) The raw materials for preparing the viscosity-adjustable hydrogel material provided in this embodiment, acrylamide, polyethylene glycol diacrylate, polyethylene oxide, dopamine hydrochloride, glycerol, lithium magnesium silicate, and water were mixed at a mixing temperature of 40° C. and stirred for 24 h to obtain a hydrogel solution precursor;

[0064] (2) adding 2-hydroxy-2-methyl-1-phenyl-1-propanone to the hydrogel solution precursor obtained in step (1), continuing to stir for more than 10 minutes to obtain a reaction system, and then pouring it into a mold;

[0065] (3) The reaction system obtained in step (2) is reacted under ultraviolet light for 2 minutes to obtain the viscosity-adjustable hydrogel material.

[0066] Example 2

[0067] A viscosity-adjustable hydrogel material. The raw materials for preparing the viscosity-adjustable hydrogel material include the following components in parts by weight: 15 parts by weight of acrylamide, 5 parts by weight of polyethylene glycol diacrylate, 0.5 parts by weight of polyethylene oxide, 0.01 parts by weight of dopamine hydrochloride, 50 parts by weight of glycerol, 0.1 parts by weight of lithium magnesium silicate, 50 parts by weight of water, and 0.2 parts by weight of 2-hydroxy-2-methyl-1-phenyl-1-propanone.

[0068] A method for preparing a viscosity-adjustable hydrogel material, which differs from Example 1 only in that the raw materials for preparation in step (1) are the raw materials for preparation provided in this example, and the remaining process parameters and steps are the same as those in Example 1.

[0069] Example 3

[0070] A viscosity-adjustable hydrogel material. The raw materials for preparing the viscosity-adjustable hydrogel material include the following components in parts by weight: 25 parts by weight of acrylamide, 1 part by weight of polyethylene glycol diacrylate, 3 parts by weight of polyethylene oxide, 1 part by weight of dopamine hydrochloride, 50 parts by weight of glycerol, 0.01 part by weight of lithium magnesium silicate, 50 parts by weight of water, and 0.2 part by weight of 2-hydroxy-2-methyl-1-phenyl-1-propanone.

[0071] A method for preparing a viscosity-adjustable hydrogel material, which differs from Example 1 only in that the raw materials for preparation in step (1) are the raw materials for preparation provided in this example, and the remaining process parameters and steps are the same as those in Example 1.

[0072] Example 4

[0073] A viscosity-adjustable hydrogel material. The raw materials for preparing the viscosity-adjustable hydrogel material include the following components in parts by weight: 30 parts by weight of acrylamide, 1 part by weight of polyethylene glycol diacrylate, 1 part by weight of polyethylene oxide, 0.01 part by weight of dopamine hydrochloride, 50 parts by weight of glycerol, 0.1 part by weight of lithium magnesium silicate, 50 parts by weight of water, and 0.2 part by weight of 2-hydroxy-2-methyl-1-phenyl-1-propanone.

[0074] A method for preparing a viscosity-adjustable hydrogel material, which differs from Example 1 only in that the raw materials for preparation in step (1) are the raw materials for preparation provided in this example, and the remaining process parameters and steps are the same as those in Example 1.

[0075] Comparative Example 1

[0076] A hydrogel material is provided, which differs from Example 3 only in that 1 part by weight of dopamine hydrochloride is not added to the raw materials for preparing the hydrogel material, and the other raw materials are the same as those in Example 3.

[0077] A method for preparing a hydrogel material, which differs from Example 3 only in that the raw materials for preparation in step (1) are the raw materials for preparation provided in this comparative example, and the remaining process parameters and steps are the same as those in Example 3.

[0078] Comparative Example 2

[0079] A hydrogel material is provided, which differs from Example 1 only in that glycerol is not added to the raw materials for preparing the hydrogel material, the amount of water added is 100 parts by weight, and the other raw materials are the same as those in Example 1.

[0080] A method for preparing a hydrogel material, which differs from Example 1 only in that the raw materials for preparation in step (1) are the raw materials for preparation provided in this comparative example, and the remaining process parameters and steps are the same as those in Example 1.

[0081] Performance Testing

[0082] (1) Self-healing performance test: The hydrogel was cut and then spliced ​​together. After standing for 48 hours, it was stretched to more than 300% without breaking.

[0083] (2) Biocompatibility test: The MTT method was used to evaluate the cytotoxicity of the material to NIH3T3 cells. The test was performed at 24 h, 72 h, and 120 h during the cell culture process. If the cell survival rate (relative stability) was ≥85%, it could be proved that the hydrogel material was biocompatible.

[0084] (3) Adhesion test: Using the peeling test method, a PET film or fiber cloth is attached to the surface of a 5×1.5×0.1 cm hydrogel, and then peeled off with a certain force. The greater the peeling force, the stronger the adhesion of the hydrogel sample.

[0085] (4) Viscoelastic tensile test: Two hydrogels of 3 × 2 × 0.2 cm in length were partially superimposed with a superposition length of 1 to 2 cm. The two ends were then fixed and stretched. The length of the hydrogel at the maximum tensile deformation was measured to obtain the maximum tensile length increment.

[0086] (5) Freeze resistance test: A hydrogel sample of 4 × 4 cm and 1 mm thick was placed in a refrigerator and frozen at -18 °C for 24 h. After taking it out, observe whether there is ice on the surface.

[0087] (6) Moisture retention test: A hydrogel sample with a diameter of 13 cm, a thickness of 4 cm and a certain mass was placed at room temperature for 7 days and then tested for quality.

[0088] The various properties of the hydrogel materials obtained in Examples 1 to 4 and Comparative Examples 1 to 2 were tested according to the above-mentioned performance testing method. The test results are shown in Figures 1 to 4 and Table 1.

[0089] Table 1

[0090] Figure 1 is a self-healing performance test photo of the hydrogel material provided in Example 3; it can be seen from Figure 1 that the hydrogel material provided in Example 3 can achieve self-healing after being cut, and can still maintain good flexibility after self-healing. Figure 2 is a self-healing performance test photo of the hydrogel material provided in Comparative Example 1; it can be seen from Figure 2 that the hydrogel material provided in Comparative Example 1 has no self-healing performance because dopamine hydrochloride is not added. Figure 3 is a viscoelastic tensile test photo of the viscosity-adjustable hydrogel material provided in Example 1; it can be seen from Figure 3 that the hydrogel material provided in Example 1 has good viscoelastic tensile properties, and the stretched length can reach 800% of the original length. Figure 4 is a comparative diagram of the adhesion of the viscosity-adjustable hydrogel materials provided in Example 1 and Example 2; it can be seen from Figure 4 that the viscosity-adjustable hydrogel material provided in this application can achieve the regulation of the viscosity and non-stickiness of the hydrogel material by regulating the amount of raw materials used in the preparation. Figure 5 is a bar graph showing the biocompatibility test of the adjustable viscosity hydrogel material provided in Example 1. Figure 5 shows that even after 120 hours, the relative stability of the adjustable viscosity hydrogel material provided in Example 1 remains as high as 95%, indicating that the hydrogel material provided in this example has good biocompatibility. Table 1 shows that the adjustable viscosity hydrogel material provided in this application has good frost resistance. When tested for moisture retention, the mass reduction rate of the adjustable viscosity hydrogel material provided in this application was 3.8%, lower than the 76.4% of Comparative Example 2, indicating that the adjustable viscosity hydrogel material provided in this application has good moisture retention.

[0091] The applicant declares that while the above-mentioned embodiments are used to illustrate the detailed process flow of the present application, the present application is not limited to the above-mentioned detailed process flow, which does not mean that the present application must rely on the above-mentioned detailed process flow in order to be implemented. Those skilled in the art should understand that any improvements to the present application, equivalent replacements for the raw materials of the present application's products, addition of auxiliary ingredients, and selection of specific methods, etc., fall within the scope of protection and disclosure of the present application.

Claims

1. A viscosity adjustable hydrogel material, wherein the raw materials for its preparation include the following components in parts by weight: 10 to 30 parts by weight of monomer, 1 to 20 parts by weight of cross-linking agent, 0.1 to 5 parts by weight of long-chain polymer, 0.01 to 5 parts by weight of dopamine hydrochloride, 0.01 to 5 parts by weight of clay and 50 to 90 parts by weight of water.

2. The viscosity-adjustable hydrogel material according to claim 1, wherein: The monomer includes any one of acrylamide, methacrylamide or hydroxyethyl methacrylate or a combination of at least two thereof.

3. The viscosity-adjustable hydrogel material according to claim 1, wherein: The cross-linking agent includes polyethylene glycol diacrylate and / or N,N'-methylenebisacrylamide; the number average molecular weight of the polyethylene glycol diacrylate is 600-1000.

4. The viscosity-adjustable hydrogel material according to claim 1, wherein: The long-chain polymer includes polyethylene oxide and / or hydroxyethyl cellulose; the average molecular weight of the polyethylene oxide is 100,000 to 8,000,000; and the viscosity of the hydroxyethyl cellulose is 100 to 6,400 mPa.s.

5. The viscosity-adjustable hydrogel material according to claim 1, wherein: The clay comprises any one of lithium magnesium silicate, carbon fiber, silver nanoparticles, silicon dioxide nanoparticles or graphene oxide, or a combination of at least two thereof; the particle size of the silver nanoparticles is 10 to 100 nm; the particle size of the silicon dioxide nanoparticles is 10 to 500 nm.

6. The viscosity-adjustable hydrogel material according to any one of claims 1 to 5, wherein: The raw materials for preparing the adjustable viscosity hydrogel material further include 10 to 50 parts by weight of a moisturizer; the moisturizer includes a polyol; and the polyol includes glycerol and / or ethylene glycol.

7. The viscosity-adjustable hydrogel material according to any one of claims 1 to 5, wherein: The raw materials for preparing the adjustable viscosity hydrogel material also include 0.2 to 2 parts by weight of an initiator; the initiator includes any one of a photoinitiator or a thermal initiator, and a photoinitiator is further preferred; the photoinitiator includes 2-hydroxy-2-methyl-1-phenyl-1-propanone and / or 2,4,6 (trimethylbenzoyl) diphenyl phosphine oxide.

8. A method for preparing the viscosity-adjustable hydrogel material according to any one of claims 1 to 7, comprising the following steps: The monomer, the cross-linking agent, the long-chain polymer, the dopamine hydrochloride, the clay and the water are mixed to obtain the hydrogel solution precursor; the hydrogel solution precursor is reacted in the presence of the initiator to obtain the viscosity-adjustable hydrogel material.

9. The preparation method according to claim 8, wherein: The mixed material also includes a moisturizer; the mixing temperature is 25 to 60° C.; the initiator is a photoinitiator, and the reaction is carried out under ultraviolet light; and the reaction time is 1 to 5 minutes.

10. Use of the viscosity-adjustable hydrogel material according to any one of claims 1 to 7 in biomedical materials or flexible electronic devices.

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