Artificial intelligence wearable device for treating primary palmar hyperhidrosis by means of non-invasive regulation and control of thoracic sympathetic nerve

Abstract

Disclosed is an artificial intelligence wearable device for treating primary palmar hyperhidrosis by means of non-invasive regulation and control of the thoracic sympathetic nerve, which comprises: a main controller, a pulse generator, a first stimulation electrode, a second stimulation electrode, and a third stimulation electrode. The pulse generator is used for generating specific pulse signals for the first, second and third stimulation electrodes. The arrangement position of the first stimulation electrode corresponds to a body surface part of the radial nerve at the wrist, the arrangement position of the second stimulation electrode corresponds to a body surface part of the median nerve at the wrist, and the arrangement position of the third stimulation electrode corresponds to a body surface part of the ulnar nerve at the wrist. Primary palmar hyperhidrosis is treated by means of pulsed electrical stimulation on the radial nerve, the median nerve, and the ulnar nerve. The device is non-invasive and non-destructive to human nerves and normal tissues, has no serious complications such as postoperative compensatory hyperhidrosis and sympathetic denervation, carries no risks such as general anesthesia accidents, provides continuous treatment along with intelligent recognition, is convenient, effective and safe, and can maintain a long-term curative effect.

Description

Artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat essential palmar hyperhidrosis Technical Field

[0001] This invention relates to the field of wearable medical device technology, and in particular to an artificial intelligence wearable device for the non-invasive treatment of primary palmar hyperhidrosis by modulating the thoracic sympathetic nerve. Background Technology

[0002] Primary palmar hyperhidrosis is a functional, localized abnormal hyperhidrosis with an unclear pathogenesis. It refers to an abnormally high level of excitability of the thoracic sympathetic nerves that control the sweat glands in the hands, leading to abnormal hyperhidrosis of the sweat glands in the hands, unaffected by external temperature. Symptoms include abnormally increased sweating of the palms due to tension, excitement, stress, or hot weather. Cold weather does not eliminate the problem of sweaty hands, and it may even lead to worse consequences, such as increased frostbite on the fingers. The prevalence of palmar hyperhidrosis among young adults in my country is approximately 4.36%, estimated to affect nearly 60 million people, seriously impacting their quality of life.

[0003] Currently, non-surgical treatment for primary palmar hyperhidrosis mainly relies on medication, but the effects are short-lived and cannot be maintained. Once the medication wears off, the sweating symptoms gradually return, making the treatment temporary. Although repeated treatment remains effective, long-term oral or injectable medications lead to drug accumulation and numerous side effects. Injection techniques are also more challenging, increasing the risk of adverse drug reactions and harm to the body. Surgical treatment primarily involves thoracic surgery, specifically thoracic sympathectomy and sympathectomy. Thoracoscopic thoracic sympathectomy is the main surgical approach, an irreversible surgical procedure that destroys nerves. This surgery requires general anesthesia and double-lumen endotracheal intubation, demanding high levels of skill in anesthesia and perioperative monitoring. Although this minimally invasive procedure allows entry into the thoracic cavity for resection, there are still risks of common thoracic surgical complications such as traumatic pneumothorax, persistent air leakage, bleeding, and effusion. After thoracic sympathectomy, palmar hyperhidrosis symptoms are alleviated to some extent within two years post-surgery. However, after two years, the symptoms progressively worsen. Many patients experience immediate postoperative compensatory sweating in other areas, excessively dry palms, and desympatheticization, with compensatory sweating, in particular, worsening their quality of life after surgery compared to before. Thoracic sympathectomy causes permanent and irreparable damage to the anatomical structure and physiological function of the sympathetic nerves. Many patients who have undergone the surgery often regret their decision. Thoracic sympathectomy essentially destroys the thoracic sympathetic nerves, and its safety and effectiveness are currently highly controversial in the international medical community. Health authorities in some countries and regions have explicitly banned this surgery. However, to date, medicine has been unable to resolve the problem of compensatory sweating after palmar hyperhidrosis surgery, significantly impacting patients' quality of life.

[0004] There is an urgent need for an effective, convenient, and non-invasive treatment method to reduce patient suffering and avoid surgical risks. Summary of the Invention

[0005] In view of the above, the present application aims to provide an effective, convenient, and non-invasive treatment method and device for primary palmar hyperhidrosis.

[0006] To achieve the object of the present application, without being bound by any theory, the inventors of the present application have surprisingly found that, by pulse electrically stimulating the surface part of a specific nerve of the wrist, the nerve electrical signal is transmitted to the thoracic sympathetic nerve through the nerve trunk and the spinal cord, and the corresponding neurotransmitter release in the brain and spinal cord is triggered, so as to inhibit the excitation of the thoracic sympathetic nerve and control the excessive secretion of hand sweat, thereby realizing the nerve regulation in a convenient, effective, low-cost, non-invasive, and companion intelligent recognition continuous treatment manner to treat primary palmar hyperhidrosis. As disclosed herein, the stimulation is therapeutic, i.e., after the onset of symptoms.

[0007] In one embodiment, the present application provides an artificial intelligence wearable device for non-invasive regulation of thoracic sympathetic nerve to treat primary palmar hyperhidrosis, which is worn on the wrist of a user, and comprises:

[0008] a main controller, a pulse generator, a first stimulation electrode, a second stimulation electrode, and a third stimulation electrode;

[0009] The pulse generator is configured to generate a specific pulse signal for the first, second, and third stimulation electrodes under the control of the main controller.

[0010] The first stimulation electrode is arranged at the surface part of the radial nerve of the wrist, is connected to the pulse generator, and emits the pulse signal to the surface part of the radial nerve.

[0011] The second stimulation electrode is arranged at the surface part of the median nerve of the wrist, is connected to the pulse generator, and emits the pulse signal to the surface part of the median nerve.

[0012] The third stimulation electrode is arranged at the surface part of the ulnar nerve of the wrist, is connected to the pulse generator, and emits the pulse signal to the surface part of the ulnar nerve.

[0013] The pulse electrically stimulates the radial nerve, the median nerve, and the ulnar nerve to treat primary palmar hyperhidrosis.

[0014] In one embodiment, the surface part of the radial nerve includes the Lieque acupoint, the surface part of the median nerve includes the Daling acupoint, and the surface part of the ulnar nerve includes the Shenmen acupoint.

[0015] In one embodiment, the pulse signal is an amplitude modulation wave signal.

[0016] In one specific implementation, the pulse signal is a positive and negative symmetrical square wave.

[0017] In one specific implementation, each pulse of the pulse signal is a positive-negative symmetrical square wave, or adjacent pulses in the pulse signal are positive-negative symmetrical.

[0018] In one specific embodiment, the pulse frequency of the pulse signal is 10-200Hz, the amplitude is 0.1-5.3s, and the current intensity is 0.1-3.9mA.

[0019] In one specific embodiment, the pulse generator produces identical pulse signals for the first, second, and third stimulation electrodes.

[0020] In one specific embodiment, the AI ​​wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis also includes an environmental information sensor for collecting environmental information and motion information, and / or a physiological parameter collector.

[0021] In one specific implementation, the main controller triggers the pulse generator to generate or stop generating the pulse signal based on the environmental information, motion information, and / or physiological parameters.

[0022] In one specific embodiment, the environmental information sensor includes a temperature sensor, a humidity sensor, an accelerometer or a gyroscope, and the physiological parameter acquisition device includes a heart rate sensor, a blood pressure acquisition device and / or a body temperature measuring device.

[0023] In one specific embodiment, the AI ​​wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis also includes a wireless communication module to receive remote medical control commands, and the main controller triggers the pulse generator to generate the pulse signal according to the remote medical control commands.

[0024] In one specific embodiment, the AI ​​wearable device further includes a wrist strap and a body. The first stimulation electrode, the second stimulation electrode, and the third stimulation electrode are disposed on the wrist strap, and a transmission circuit is embedded in the wrist strap. The main controller and the pulse generator are disposed in the body, and the transmission circuit connects the first stimulation electrode, the second stimulation electrode, and the third stimulation electrode to the pulse generator.

[0025] In one specific embodiment, a method for treating primary palmar hyperhidrosis is provided, comprising: continuously applying electrical stimulation to three anatomical sites on the wrist: the median nerve, ulnar nerve, and radial nerve. In another specific embodiment, stimulation electrodes are positioned at these three anatomical sites on the wrist for continuous electrical stimulation.

[0026] In one specific embodiment, a method for treating primary palmar hyperhidrosis is provided, comprising: continuously applying electrical stimulation to three acupuncture points in Traditional Chinese Medicine (TCM): Shenmen, Daling, and Lieque on the wrist. In one specific embodiment, stimulation electrodes are positioned at the three acupuncture points on the wrist and continuously applied electrical stimulation.

[0027] In one specific implementation, the stimulation duration is 15-60 minutes, for example, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60 minutes.

[0028] According to another aspect of the present invention, the present invention provides the application of the median nerve, ulnar nerve, and radial nerve in the treatment of primary palmar hyperhidrosis.

[0029] In one specific implementation, the application includes continuous electrical stimulation of three anatomical sites on the surface of the median nerve, ulnar nerve, and radial nerve.

[0030] According to another aspect of the present invention, the present invention provides the application of Shenmen acupoint, Daling acupoint, and Lieque acupoint in the treatment of primary palmar hyperhidrosis.

[0031] In one specific implementation, the application includes continuous electrical stimulation of three acupuncture points in traditional Chinese medicine: Shenmen, Daling, and Lieque.

[0032] According to the present invention, by wearing an electronic device, there is no need for surgical treatment, no need to sever or destroy the human thoracic sympathetic nerve, no adverse drug reactions, no risks of general anesthesia accidents, etc., which solves the serious complications such as postoperative compensatory hyperhidrosis and desympatheticization of palmar hyperhidrosis that have plagued clinical practice for many years, and the safety of treatment is significantly improved.

[0033] Primary palmar hyperhidrosis presents with varying degrees of symptoms throughout the day. The solution of this invention can adaptively adjust various parameters and stimulation time of the control pulse at different time periods to achieve proper regulation of the thoracic sympathetic nerves, maintain the normal moisture level of the palm skin, and avoid the side effect of excessive dryness of the palms.

[0034] This invention provides a safe, non-invasive, and continuous treatment method with intelligent recognition, without damaging human nerves or normal tissues, and without postoperative complications such as compensatory hyperhidrosis and desympatholysis. It is convenient, effective, and low-cost, and has a good therapeutic effect on primary palmar hyperhidrosis. The therapeutic effect can be maintained for a long time, reducing treatment costs.

[0035] The solution of this invention can achieve continuous electrical stimulation of the cutaneous nerve, maintain the therapeutic effect continuously, and automatically judge the human body status, automatically shut down, and end the treatment. Attached Figure Description

[0036] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used in conjunction with embodiments of the invention to explain the invention, but do not constitute a limitation thereof. In the drawings:

[0037] Figure 1 shows a schematic diagram of the structure of the artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis according to the present invention;

[0038] Figure 2 shows a schematic diagram of the nerve distribution in the human hand;

[0039] Figure 3 shows a schematic diagram of the surface locations of the radial nerve, median nerve, and ulnar nerve;

[0040] Figure 4 shows a schematic diagram of the functional framework of the artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis according to the present invention.

[0041] Figures 5 and 6 show schematic diagrams of pulse signal waveforms. Detailed Implementation

[0042] The following description of the implementation process of the technical solution of the present invention with reference to specific embodiments is not intended to limit the present invention.

[0043] This invention provides an artificial intelligence wearable device for the non-invasive treatment of primary palmar hyperhidrosis by modulating the thoracic sympathetic nerve. Specifically, it can be configured as a watch, bracelet, wristband, or wristband. However, it should be understood that other devices worn on the wrist are also within the scope of this invention. Alternatively, this invention can be integrated as a module into existing wrist-worn wearable devices.

[0044] Not limited to any theory, according to the present invention, when the artificial intelligence wearable device is worn on the wrist, stimulation electrodes are provided at the component corresponding to the palm side to perform pulsed electrical stimulation on the surface of specific nerves in the wrist, so that the nerve electrical signals are transmitted to the thoracic sympathetic nerve through the nerve trunk and spinal cord, stimulating the release of corresponding neurotransmitters in the brain and spinal cord, thereby inhibiting the excitation of the thoracic sympathetic nerve and controlling excessive sweating of the hands.

[0045] This invention provides a non-invasive, accompanying intelligent recognition-based continuous treatment that is convenient, effective, and low-cost for neuromodulation, demonstrating excellent efficacy in treating primary palmar hyperhidrosis while reducing treatment costs.

[0046] Figure 1 shows a schematic diagram of the structure of the artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis according to the present invention, using a smartwatch as an example. Other common functional modules of smartwatches are not shown in the figure.

[0047] Figure 2 shows a schematic diagram of the nerve distribution in the human hand.

[0048] Figure 3 shows a schematic diagram of the surface locations of the radial nerve, median nerve, and ulnar nerve.

[0049] Figure 4 shows a schematic diagram of the functional framework of the artificial intelligence wearable device for the non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis according to the present invention.

[0050] The wearable AI device 100 has a main body and a wrist strap. The main body can be a watch face. The wrist strap is equipped with a first stimulation electrode 10, a second stimulation electrode 20, and a third stimulation electrode 30. The main controller 40 and a pulse generator 50 are installed inside the watch face. The main controller 40 is connected to the first stimulation electrode 10, the second stimulation electrode 20, and the third stimulation electrode 30 through a transmission circuit, which is embedded in the wrist strap.

[0051] The human arm contains the radial nerve, median nerve, and ulnar nerve, all of which are responsible for the sensory function of the skin and the autonomic nerve function.

[0052] The first stimulating electrode 10 is positioned to correspond to the surface area of ​​the radial nerve in the wrist, the second stimulating electrode 20 is positioned to correspond to the surface area of ​​the median nerve in the wrist, and the third stimulating electrode 30 is positioned to correspond to the surface area of ​​the ulnar nerve in the wrist.

[0053] The radial nerve's surface location includes the Lieque acupoint, the median nerve's surface location includes the Daling acupoint, and the ulnar nerve's surface location includes the Shenmen acupoint. The first stimulating electrode 10 simply needs to be applied to the corresponding surface location of the radial nerve; the second and third stimulating electrodes work similarly, all stimulating the corresponding nerves through pulse signals emitted by the electrodes. Preferably, the first stimulating electrode 10 is applied to the Lieque acupoint. Preferably, the second stimulating electrode 20 is applied to the Daling acupoint. Preferably, the third stimulating electrode 30 is applied to the Shenmen acupoint.

[0054] The main controller 40 is connected to the pulse generator 50, and the pulse generator 50 is connected to the first stimulation electrode 10, the second stimulation electrode 20, and the third stimulation electrode 30 respectively.

[0055] The pulse generator 50 is used to generate specific pulse signals under the control of the main controller 40, and the specific pulse signals are transmitted to the first, second and third stimulation electrodes.

[0056] The first stimulating electrode emits a pulse signal to the surface of the radial nerve. The second stimulating electrode emits the same pulse signal to the surface of the median nerve. The third stimulating electrode emits the same pulse signal to the surface of the ulnar nerve. The nerve signals are transmitted through the nerve trunk and spinal cord to the thoracic sympathetic nerves, stimulating the release of corresponding neurotransmitters in the brain and spinal cord, thereby inhibiting thoracic sympathetic nerve excitation. The thoracic sympathetic nerves then transmit the inhibitory signal to the sweat glands in the palms, inhibiting their secretion and thus eliminating the symptoms of palmar hyperhidrosis. The pulse signal uses an amplitude-modulated wave. Considering the effective energy and safety of the patient, the usable pulse frequency range is 10-200Hz, the usable amplitude range is 0.1-5.3s, and the usable current intensity range is 0.1-3.9mA. Typically, the pulse signal stimulation needs to last for 15-30 minutes to produce a therapeutic effect.

[0057] The pulse signal can be a positive and negative symmetrical square wave. Specifically, each pulse of the pulse signal is a positive and negative symmetrical square wave (as shown in Figure 5), or adjacent pulses in the pulse signal are positive and negative symmetrical (as shown in Figure 6).

[0058] The pulse generator 50 generates identical pulse signals for the first, second, and third stimulation electrodes. Because the three stimulation electrodes receive the same signal, the stimulation intensity of each electrode is exactly the same, eliminating asymmetry in stimulation intensity and electrode polarization, thus ensuring that no electric shock accident occurs.

[0059] For the pulse signal shown in Figure 6, since each pulse has a positive and negative symmetrical waveform, the pulse energy is doubled, and the stimulation effect per unit time is enhanced.

[0060] As shown in Figure 4, the AI ​​wearable device 100 also includes an environmental information sensor 70 for collecting environmental and motion information, and / or a physiological parameter acquisition device 60. The environmental information sensor includes a temperature sensor, a humidity sensor, an accelerometer, and / or a gyroscope, and the physiological parameter acquisition device includes a heart rate sensor, a blood pressure acquisition device, and / or a body temperature measuring device.

[0061] The AI ​​wearable device 100 also includes a storage unit 90 for storing pulse signal triggering schemes. The main controller 40 triggers the pulse generator to generate or stop generating the pulse signal based on environmental information, motion information, and / or physiological parameters. The main controller 40 can also trigger the pulse generator to generate or stop generating the pulse signal according to a preset scheme. The preset scheme can be timed triggering / shutdown.

[0062] The AI ​​wearable device 100 can collect physiological information from the human body through the physiological parameter acquisition device 60, and select and execute a treatment plan based on this information. For example, it can determine whether a person has woken up or entered sleep by measuring heart rate, blood pressure, and body temperature. This transition in sleep state is a crucial point in the development of hyperhidrosis. The storage unit 90 stores the pulse triggering scheme corresponding to the transition in sleep state based on heart rate. For example, when the main controller determines that the person has woken up based on the data collected by the physiological parameter acquisition device, it triggers the pulse generator 50 to generate pulse signals according to the pulse triggering scheme. The three stimulation electrodes continuously emit pulse signals for 15 minutes and then automatically stop. After a 15-minute interval, the pulse signals can be emitted again for another 15 minutes before stopping. When the main controller determines that the person has entered sleep based on the data collected by the physiological parameter acquisition device, it controls the pulse generator 50 to stop generating pulse signals. Other triggering schemes are also within the scope of this invention.

[0063] The AI ​​wearable device 100 can collect environmental or motion information through the current time and the environmental information sensor 70. For example, it can determine the environment and movement mode of the human body through temperature sensor, humidity sensor, accelerometer or gyroscope, and then determine the degree of sweating. The main controller adaptively and dynamically adjusts the parameters of the pulse signal according to the pulse triggering scheme to control the stimulation time.

[0064] In one embodiment, when the heart rate reaches 81 beats / min and the blood pressure reaches approximately 130 / 70 mmHg, the stimulation time is adjusted to be more than 30 minutes. As shown in Figure 4, the AI ​​wearable device 100 also includes a wireless communication module 80, which can be a 5G module, to connect with a remote medical platform. This module transmits information collected by the physiological parameter acquisition device 60 and the environmental information sensor 70, image information captured by the AI ​​wearable device 100, and text information sent by the AI ​​wearable device 100 to the remote medical platform. The server of the remote medical platform or a remotely connected medical service personnel then issues remote medical control commands based on the patient's condition. The AI ​​wearable device 100 receives these remote medical control commands through the wireless communication module, and the main controller triggers the pulse generator 50 to generate the pulse signal based on the remote medical control commands.

[0065] The following describes some application examples of the present invention.

[0066] Patient 1, Zhao, male, 23 years old, a member of the Chinese National Boxing Team, was clinically diagnosed with severe primary palmar hyperhidrosis, characterized by excessive sweating of both hands. He was originally an inpatient in the Department of Thoracic Surgery, but refused open-chest surgery. Later, he voluntarily underwent experimental treatment using the method described in this invention at the research laboratory of the Department of Neurobiology, Capital Medical University. After using the device for 30 minutes, the hand sweating disappeared. After discontinuing the use of the device, the hands remained sweat-free for 60 minutes. Subsequent follow-up showed no other abnormalities.

[0067] Patient 2, Mr. Zhang, male, 29 years old, was clinically diagnosed with primary palmar hyperhidrosis, moderate, characterized by scattered beads of sweat on both hands. After using this device for 5 minutes, the sweating began to lessen. After 15 minutes, the sweating disappeared. After discontinuing use of the device, the hands remained sweat-free for 60 minutes.

[0068] In clinical practice, maintaining anhidrosis for 60 minutes after nerve stimulation is terminated is considered clinically effective.

[0069] To date, the inventors have conducted clinical treatment on 189 patients diagnosed with moderate to severe primary palmar hyperhidrosis at Capital Medical University using the technical solution of this invention. The results showed that all patients maintained anhidrosis for 60 minutes after treatment. This invention demonstrates good therapeutic effects on various types of primary palmar hyperhidrosis and possesses clinical effectiveness.

[0070] This invention provides a non-invasive, accompanying, intelligent, convenient, and effective method for regulating the thoracic sympathetic nerves. It eliminates the need for surgery, the severing or destruction of the thoracic sympathetic nerves, and carries no adverse drug reactions or risks associated with general anesthesia. It offers excellent and safe efficacy in treating primary palmar hyperhidrosis, avoiding serious complications such as postoperative compensatory hyperhidrosis and desympatheticization. The treatment is safe, effective, sustainable, repeatable, and reduces treatment costs. Since the severity of symptoms in primary palmar hyperhidrosis varies throughout the day, this invention's approach can adaptively adjust various parameters and stimulation times of the control pulses at different times to achieve intelligent regulation of the thoracic sympathetic nerves, maintaining normal skin moisture levels and avoiding excessive dryness. This invention enables continuous cutaneous nerve electrical stimulation, allowing for long-term treatment, maintaining therapeutic effects, and automatically assessing the patient's condition to shut down and terminate the treatment.

[0071] The above embodiments are only used to describe the technical solutions of the present invention and are not to be regarded as limitations on the present invention.

Claims

1. A non-invasive wearable AI device for treating primary palmar hyperhidrosis by modulating the thoracic sympathetic nerve, worn on the user's wrist, characterized in that... This AI-powered wearable device includes: The main controller, pulse generator, first stimulation electrode, second stimulation electrode, and third stimulation electrode; The pulse generator is used to generate specific pulse signals for the first, second, and third stimulation electrodes under the control of the main controller; The first stimulation electrode is positioned corresponding to the surface area of ​​the radial nerve in the wrist. The first stimulation electrode is connected to the pulse generator and emits the pulse signal to the surface area of ​​the radial nerve. The second stimulation electrode is positioned corresponding to the surface area of ​​the median nerve in the wrist. The second stimulation electrode is connected to the pulse generator and emits the pulse signal to the surface area of ​​the median nerve. The third stimulation electrode is positioned corresponding to the surface area of ​​the ulnar nerve in the wrist. The third stimulation electrode is connected to the pulse generator and emits the pulse signal to the surface area of ​​the ulnar nerve. Primary palmar hyperhidrosis was treated by pulsed electrical stimulation of the radial, median, and ulnar nerves.

2. The artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis as described in claim 1, characterized in that, The radial nerve has acupoint Lieque on its surface, the median nerve has acupoint Daling on its surface, and the ulnar nerve has acupoint Shenmen on its surface.

3. The artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis as described in claim 1, characterized in that, The pulse signal is an amplitude-modulated wave signal.

4. The artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis as described in claim 3, characterized in that, The pulse signal is a positive and negative symmetrical square wave.

5. The artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis as described in claim 4, characterized in that, Each pulse of the pulse signal is a positive-negative symmetrical square wave, or adjacent pulses in the pulse signal are positive-negative symmetrical.

6. The artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis as described in claim 3, characterized in that, The pulse frequency of this pulse signal is 10-200Hz, the amplitude is 0.1-5.3s, and the current intensity is 0.1-3.9mA.

7. The artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis as described in any one of claims 1-6, characterized in that, The pulse generator produces identical pulse signals for the first, second, and third stimulation electrodes.

8. The artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis as described in claim 1, characterized in that, It also includes environmental information sensors for collecting environmental and motion information, and / or physiological parameter acquisition devices; The main controller triggers the pulse generator to generate or stop generating the pulse signal based on the environmental information, motion information, and / or physiological parameters.

9. The artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis as described in claim 8, characterized in that, The environmental information sensor includes a temperature sensor, a humidity sensor, an accelerometer or a gyroscope, and the physiological parameter acquisition device includes a heart rate sensor, a blood pressure acquisition device and / or a body temperature measurement device.

10. The artificial intelligence wearable device for non-invasive modulation of the thoracic sympathetic nerve to treat primary palmar hyperhidrosis as described in claim 1, characterized in that, It also includes a wireless communication module to receive remote medical control commands, and the main controller triggers the pulse generator to generate the pulse signal according to the remote medical control commands.

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