Herbicidal combinations

Abstract

The present disclosure relates to a herbicidal combination comprising a carbamate herbicide and at least one additional protoporphyrinogen oxidase (PPO) inhibitor herbicide. In particular, the disclosure relates to combinations of the carbamate asulam with at least one PPO inhibitor selected from carfentrazone, saflufenacil, tiafenacil, fomesafen, flumioxazin or epyrifenacil.

Description

[0001] HERBICIDAL COMBINATIONS

[0002] FIELD OF THE INVENTION:

[0003] The present disclosure relates to a herbicidal combination comprising a carbamate herbicide and at least one additional herbicide. Furthermore, the present disclosure relates to a method for controlling weeds by applying an effective amount of the herbicidal combination thereof.

[0004] BACKGROUND OF THE INVENTION:

[0005] Herbicides are chemical substances, which are used to control unwanted plants / weeds. The mode of action for herbicides is a biochemical or a physical mechanism, which disrupts or alters one or more of the metabolic processes of the unwanted plants / weed, thereby controlling their growth. Therefore, when and how any herbicide should be applied may be determined by the mode of action of the herbicide. However, there are certain species or groups of unwanted plants / weeds, which are susceptible to certain herbicides and not susceptible to certain herbicides. This may be because either the herbicides use different biochemical pathways, or the herbicides have slightly different enzymes. In situations, when one herbicide is ineffective, additional herbicide(s) with different modes of action may provide better results.

[0006] Protoporphyrinogen oxidase (PPO) inhibitors, or Group 14 herbicides, are labelled for pre-emergence as well as post-emergence applications in soybean. These herbicides interfere with the production of chlorophyll for photosynthesis and rapidly destroy tissue. Symptoms of herbicide injury from pre-emergence PPO applications are usually due to one of three causes: herbicide being splashed or washed onto tissue at or just after emergence; poor furrow closure allowing herbicide to be applied or washed directly into a furrow following a rainfall; or slow metabolism by soybeans during prolonged cold and wet periods. Post-emergence use of PPO herbicides leads to speckling or necrotic tissue that the herbicide contacts. Injury is most likely to occur when post-emergence applications are made during hot, humid weather or if long periods of cold temperatures follow application. Therefore, there is a need to combine PPO inhibitors when another herbicide, to overcome the aforementioned issues / drawbacks.

[0007] Asulam, also known as methyl A-(4-aminophenyl)sulfonylcarbamate), is a broadspectrum carbamate herbicide. Asulam is a plant growth inhibitor which inhibits folate synthesis by suppression of dihydropteroate synthase (DHPS) in plants. The structure of Asulam is represented as:

[0008] Asulam is especially useful for post-emergence control of perennial grasses in crops such as sugarcane, soybean, cotton, etc. It provides effective control for a wide variety of herbicide-resistant and herbicide-tolerant weeds while reducing phyto toxicity in crops.

[0009] Furthermore, herbicidal combinations known in the art usually have some disadvantages. They have none or insufficient herbicidal activity against specific unwanted plants / weeds, the spectrum of unwanted plants / weeds which can be controlled with the herbicides is not broad enough, the selectivity and compatibility of the herbicides with crops is too low, thereby causing unwanted damage and / or reduced yield of the crops, the initial herbicidal activity is not acceptable or not strong enough, and / or the herbicidal activity does not last long enough. For these reasons, there is a constant need to develop herbicidal combinations which overcome the aforementioned disadvantages. There also exists a need for an environmentally safe herbicidal combination that can selectively control unwanted plants / weeds, while leave other plants and crop unharmed.

[0010] OBJECTIVES OF THE INVENTION:

[0011] It is a primary objective of the present disclosure to provide a herbicidal combination comprising a carbamate herbicide and at least one additional herbicide, for controlling or preventing unwanted plants / weeds in crops.

[0012] It is yet another objective of the present disclosure to provide a herbicidal combination possessing enhanced efficacy over the individual herbicides.

[0013] It is another objective of the present disclosure to provide a herbicidal combination achieving increased yield in the crops to which they are applied, by reducing the number of weeds in the crops.

[0014] SUMMARY OF THE INVENTION:

[0015] In an aspect, the present disclosure provides a herbicidal combination comprising: a carbamate herbicide; and at least one additional herbicide selected from PPO inhibitor herbicides.

[0016] In yet another aspect, the present disclosure provides a method for efficient control, suppression or eradication of weeds by applying an effective amount of the herbicidal combination comprising a carbamate herbicide and at least one additional herbicide.

[0017] DETAILED DESCRIPTION OF THE INVENTION:

[0018] The present disclosure now will be described hereinafter with reference to the accompanying examples, in which embodiments of the disclosure are shown. This description is not intended to be a detailed catalogue of all the different ways in which the disclosure may be implemented, or all the features that may be added to the instant disclosure. In addition, numerous variations and additions to the various embodiments suggested herein will be apparent to those skilled in the art in light of the instant disclosure, which do not depart from the instant disclosure. Hence, the following descriptions are intended to illustrate some particular embodiments of the disclosure, and not to exhaustively specify all permutations, combinations and variations thereof.

[0019] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the disclosure, suitable methods and materials are described herein.

[0020] “About” or “approximately” as used herein is inclusive of the stated value and means within an acceptable range of deviation for the particular value as determined by one of ordinary skill in the art, considering the measurement in question and the error associated with measurement of the particular quantity (i.e., the limitations of the measurement system). For example, “about” can mean within one or more standard deviations, or within ±10 or ±5 percent of the stated value.

[0021] The use of the terms “a”, “an”, and “the” and similar referents (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The terms first, second etc., as used herein are not meant to denote any particular ordering, but simply for convenience to denote a plurality of, for example, layers.

[0022] The terms “comprising”, “having”, “including”, and “containing” are to be construed as open-ended terms (i.e., meaning “including, but not limited to”) unless otherwise noted. The use of any and all examples, or exemplary language (e.g., “such as”), is intended merely to better illustrate the disclosure and does not pose a limitation on the scope of the disclosure unless otherwise claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the disclosure as used herein.

[0023] The term “control” relates to a weed, includes control of the weed, as well as protecting a plant, a portion of the plant, or a plant seed from attack or invasion by said weed.

[0024] The term “herbicide” encompasses both herbicides as well as plant growth regulators, as far as this does not otherwise emerge from the context. The term herbicide as used herein denotes a compound which controls or modifies the growth of undesired weeds / plants. The term “herbicidally effective amount” indicates the quantity of such a compound or combination of such compounds which is capable of controlling or modifying effect on the growth of harmful plants / undesired vegetation / weeds. Controlling effects include all deviation from natural development, for example: killing, retardation, leaf bum, albinism, dwarfism, etc.

[0025] As used herein the term “plant” or “crop” refers to whole plants, plant organs (e.g., leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.), plant cells, and plant seeds. This term also encompasses plant crops such as fruits. The term “plant” may further include the propagation material thereof, which may include all the generative parts of the plant such as seeds and vegetative plant material such as cuttings and tubers, which can be used for the multiplication of the plant. This includes seeds, tubers, spores, corms, bulbs, rhizomes, sprouts basal shoots, stolon, and buds and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil.

[0026] As used herein, the term “plant propagation material” is understood to denote generative parts of a plant, such as seeds, vegetative material such as cuttings or tubers, roots, fruits, tubers, bulbs, rhizomes and parts of plants, germinated plants and young plants which are to be transplanted after germination or after emergence from the soil. These young plants may be protected before transplantation by a total or partial treatment by immersion.

[0027] As used herein, the term “seed” embraces seeds and plant propagules of all kinds including but not limited to true seeds, seed pieces, suckers, corms, bulbs, fruit, tubers, grains, cuttings, cut shoots and the like. In a preferred embodiment a seed is a true seed.

[0028] As used herein, the term “pre-emergence” refers to the time point before seedlings emerge from the ground. When any herbicide is applied at pre-emergence stage, it prevents establishment of the germinated weed seedlings. As used herein, the term “post-emergence” refers to the time point after seedlings emerge from the ground. When any herbicide is applied at post-emergence stage, it prevents growth of the germinated weed seedlings.

[0029] As used herein, the term “increased yield” of an agricultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the compositions described herein. According to the present disclosure, it is preferred that the crop yield be increased by at least 0.5%, preferably at least 2%, more preferably at least 5%, upon application of the combinations and compositions described herein.

[0030] The term “weed” as used herein refers to the plant whose growth is considered undesirable in a particular situation i.e., growth of a plant at a wrong place and includes pesticide resistant plants. In the broadest sense, the term “weed” refers to plants which grow in locations in which they are not desired. In other words, a “weed” is a plant in which in the context of a crop is undesirable due to competition for water, nutrients, sunlight, soil, etc. The term may also refer to crop plants which are undesirable at a location. As used herein, the terms “undesirable vegetation”, “harmful plants”, “unwanted plants”, “weeds” and “weed species”, as used herein, are synonyms.

[0031] Typically, the combinations / compositions of the present disclosure are applied to the targeted weed or to their locus or to the crop / plant. The term “locus” as used herein shall denote the vicinity of a desired crop in which weed control, typically selective weed control is desired. The locus includes the vicinity of desired crop plants wherein the weed infestation has either emerged or is yet to emerge. The term crop shall include a multitude of desired crop plants or an individual crop plant growing at a locus. The said locus could be a weed, an area adjacent to the weed, soil adapted to support growth of the weed, a root of the weed and / or foliage of the weed.

[0032] As used herein, the term “phytotoxicity” refers to any adverse effect or reaction on plant growth, physiology, or metabolism caused by any chemical substance, fertilizer, herbicide, heavy metal, etc.

[0033] As used herein, the term “PPO inhibitor herbicides” refers to Group 14 herbicides, which are primarily contact-type, post-emergence, broadleaf-weed herbicides, but a few have pre-emergence soil activity. The primary mechanism of action of these herbicides is inhibition of the PPO enzyme which ultimately leads to disruption of cell membranes.

[0034] According to an embodiment, the present disclosure provides a herbicidal combination for controlling weeds. In another embodiment, the present disclosure provides a herbicidal combination for controlling herbicide -resistant weeds and / or herbicide-tolerant weeds.

[0035] In another embodiment, the present disclosure provides a herbicidal combination comprising a carbamate herbicide and at least one additional herbicide. In another embodiment, the present disclosure provides a herbicidal combination comprising a carbamate herbicide and at least one PPO inhibitor herbicide.

[0036] In an embodiment, the mode of action of the carbamate herbicide is by inhibition of dihydropteroate synthase. In another embodiment, the carbamate herbicide is selected from the group comprising asulam, barban, 1 -methylpropyl (3- chlorophenyl)carbamate (BCPC), carbasulam, carbetamide, carboxazole, 2- chloroethyl-N-3-chlorophenylcarbamate (CEPC), chlorbufam, 2-chloro- 1- methylethyl (3-chlorophenyl)carbamate (CPPC), dichlormate, famoxacarb, fenasulam, propham, swep, terbucarb, or combinations thereof. In a preferred embodiment, the carbamate herbicide is asulam.

[0037] In another embodiment, the PPO inhibitor herbicide is selected from one or more herbicides, their salts, esters, isomers, or combinations thereof. Table 1

[0038] In a preferred embodiment, the PPO inhibitor herbicides are selected from the group comprising carfentrazone-ethyl, flumioxazin, fomesafen, saflufenacil, tiafenacil, epyrifenacil, or combinations thereof.

[0039] In a preferred embodiment, the PPO inhibitor herbicide is selected from carfentrazone, carfentrazone-ethyl, or combinations thereof. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and carfentrazone. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and carfentrazone-ethyl.

[0040] In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and acifluorfen. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and azafenidin. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and bifenox. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and butafenacil. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and cinidonethyl. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and epyrifenacil. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and flumiclorapentyl. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and flumioxazin. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and fluthiacetmethyl. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and fomesafen. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and lactofen. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and oxadiargyl. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and oxadiazon. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and oxyfluorfen. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and pentoxazone. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and pyraclonil. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and pyraflufenethyl. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and saflufenacil. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and sulfentrazone. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and tiafenacil. In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and trifludimoxazin.

[0041] According to an embodiment, the present disclosure provides a herbicidal combination comprising a carbamate herbicide and at least one additional herbicide, wherein the carbamate herbicide and the additional herbicide are present in a weight ratio from about 1: 100 to about 100: 1, preferably from about 1:90 to about 90: 1, preferably from about 1:80 to about 80: 1, preferably from about 1:70 to about 70: 1, preferably from about 1:60 to about 60: 1, preferably from about 1:50 to about 50: 1, preferably from about 1:40 to about 40: 1, preferably from about 1:30 to about 30: 1, preferably from about 1:20 to about 20: 1, preferably from about 1: 10 to about 10: 1, preferably from about 1:5 to about 5: 1, and more preferably from about 1:3 to about 3: 1. Unless otherwise indicated, the ratios disclosed throughout the specification are weight ratios.

[0042] In another embodiment, the present disclosure provides a herbicidal composition comprising: a carbamate herbicide; at least one additional herbicide; and at least one agrochemically acceptable excipient.

[0043] In another embodiment, the present disclosure provides a herbicidal composition comprising: a carbamate herbicide; at least one PPO inhibitor herbicide; and at least one agrochemically acceptable excipient.

[0044] In another embodiment, the present disclosure provides a herbicidal composition comprising: asulam; at least one PPO inhibitor herbicide; and at least one agrochemically acceptable excipient.

[0045] According to an embodiment of the present disclosure, the agrochemically acceptable excipients are selected from the group comprising emulsifier(s), colorant(s), thickener(s) / binder(s), antifreeze agent(s), antifoaming agent(s), antioxidant(s), solvent(s), preservative(s), glidant(s), anticaking agent(s), pH- regulating agent(s), buffering agent(s), formulation aid(s), disintegrant(s), or combinations thereof.

[0046] In another embodiment, in the herbicidal composition the carbamate herbicide is present from about 10% w / w to about 90% w / w, preferably from about 10% w / w to about 70% w / w, preferably from about 10% w / w to about 60% w / w, and more preferably from about 10% w / w to about 50% w / w of total weight of the composition.

[0047] In another embodiment, in the herbicidal composition the additional herbicide is present from about 10% w / w to about 90% w / w, preferably from about 10% w / w to about 70% w / w, preferably from about 10% w / w to about 60% w / w, and more preferably from about 10% w / w to about 50% w / w of total weight of the composition.

[0048] In another embodiment, in the herbicidal composition the agrochemically acceptable excipient is present from about 10% w / w to about 90% w / w of total weight of the composition.

[0049] In another embodiment, the present disclosure provides use of the herbicidal combination for controlling weeds, the combination comprising: a carbamate herbicide; and at least one additional herbicide.

[0050] In another embodiment, the present disclosure provides use of the herbicidal combination for controlling weeds, the combination comprising: a carbamate herbicide; and at least one PPO inhibitor herbicide.

[0051] In another embodiment, the present disclosure provides use of the herbicidal combination for controlling weeds, the combination comprising: asulam; and at least one PPO inhibitor herbicide.

[0052] In another embodiment, the present disclosure provides use of the herbicidal combination for controlling weeds. In an embodiment, the present disclosure provides use of a herbicidal combination, for controlling herbicide-resistant and / or herbicide-tolerant weeds. In an embodiment, the present disclosure provides use of a herbicidal combination, for improving yield of the desired crop.

[0053] In another embodiment, the present disclosure provides a method for controlling weeds, wherein the method comprises applying to a plant or a locus thereof an effective amount of a herbicidal combination comprising: a carbamate herbicide; and at least one additional herbicide.

[0054] In another embodiment, the present disclosure provides a method for controlling weeds, wherein the method comprises applying to a plant or a locus thereof an effective amount of a herbicidal combination comprising: a carbamate herbicide; and at least one PPO inhibitor herbicide.

[0055] In another embodiment, the present disclosure provides a method for controlling weeds, wherein the method comprises applying to a plant or a locus thereof an effective amount of a herbicidal combination comprising: asulam; and at least one PPO inhibitor herbicide.

[0056] In another embodiment, the present disclosure provides a method for controlling weeds by application of the herbicidal combination. In another embodiment, the present disclosure provides a method for controlling herbicide -resistant and / or herbicide-tolerant weeds by application of the herbicidal combination.

[0057] In another embodiment, the present disclosure provides a method for controlling weeds by application of an effective amount of the herbicidal combination to a plant, or a plant propagation material, or a locus thereof. The selection of the effective amount depends on the density of weed infestation, weather patterns, crop health, etc. In an embodiment, the present disclosure provides a method for controlling weeds, wherein the weeds are treated by applying concurrently or subsequently or sequentially the herbicidal combination.

[0058] According to an embodiment, the herbicidal combination / compo sition is present either in a form of a tank mix or a pre-formulated (pre-mix) composition.

[0059] In another embodiment, the herbicidal combination comprises a carbamate herbicide applied at an application rate from about 1 g a.i. / ha to about 2000 g a.i. / ha, preferably from about 100 g a.i. / ha to about 2000 g a.i. / ha, preferably from about 500 g a.i. / ha to about 2000 g a.i. / ha, preferably from about 750 g a.i. / ha to about 2000 g a.i. / ha, preferably from about 1000 g a.i. / ha to about 2000 g a.i. / ha, and more preferably from about 1100 g a.i. / ha to about 1900 g a.i. / ha.

[0060] In a preferred embodiment, the herbicidal combination comprises asulam applied at an application rate of about 800 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises asulam applied at an application rate of about 1200 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises asulam applied at an application rate of about 1400 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises asulam applied at an application rate of about 1500 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises asulam applied at an application rate of about 1800 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises asulam applied at an application rate of about 1880 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises asulam applied at an application rate of about 2000 g a.i. / ha.

[0061] In another embodiment, the herbicidal combination comprises at least one additional herbicide applied at an application rate from about 1 g a.i. / ha to about 400 g a.i. / ha, preferably from about 1 g a.i. / ha to about 300 g a.i. / ha, preferably from about 10 g a.i. / ha to about 350 g a.i. / ha, preferably from about 10 g a.i. / ha to about 300 g a.i. / ha, preferably from about 20 g a.i. / ha to about 280 g a.i. / ha, and more preferably from about 25 g a.i. / ha to about 250 g a.i. / ha.

[0062] In a preferred embodiment, the herbicidal combination comprises carfentrazone applied at an application rate of about 30 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises saflufenacil applied at an application rate of about 25 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises tiafenacil applied at an application rate of about 70 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises fomesafen applied at an application rate of about 250 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises flumioxazin applied at an application rate of about 30 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises epyrifenacil applied at an application rate of about 11 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises epyrifenacil applied at an application rate of about 22 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises epyrifenacil applied at an application rate of about 33 g a.i. / ha.

[0063] In a preferred embodiment, the herbicidal combination comprises a carbamate herbicide applied at an application rate from about 1 g a.i. / ha to about 2000 g a.i. / ha and at least one additional herbicide applied at an application rate from about 1 g a.i. / ha to about 400 g a.i. / ha.

[0064] In a preferred embodiment, the herbicidal combination comprises a carbamate herbicide applied at an application rate from about 1 g a.i. / ha to about 2000 g a.i. / ha and at least one PPO inhibitor herbicide applied at an application rate from about 1 g a.i. / ha to about 400 g a.i. / ha.

[0065] In another embodiment, the combination of the present disclosure is used to control weeds in various agricultural crops. Non-limiting examples of weeds controlled by the combination of the present disclosure include Gossypium hirsutum, Raphanus raphanistrum, Raphanus sativus, Sinapis arvensis, Capsella bursa-pastoris, Brassica juncea, Brassica campestris, Descurainia pinnata, Rorippa islandica, Rorippa sylvestris, Thlaspi arvense, Myagrum rugosum, Lepidium virginicum, Coronopus didymus, Dinebra retroflexa, Cynodon dactylon, Echinochloa colonum, Echinochloa crusgalli, Setaria viridis, Setaria faberi, Setaria glauca, Setaria ilosa ate, Digitaria ciliaris, Digitaria sanguinalis, Digitaria horizontalis, Digitaria insularis, Eleusine indica, Poa annua, Alospecurus aequalis, Alopecurus myosuroides, Avena sp., Avena fatua, Sorghum halepense, Sorghum vulgare, Agropyron repens, Eolium multiflorum, Eolium perenne, Eolium rigidum, Bromus secalinus, Bromus tectorum, Elordeum jubatum, Aegilops cylindrica, Phalaris arundinacea, Phalaris minor, Apera spicaventi, Panicum dichotomiflorum, Panicum texanum, Panicum maximum, Brachiaria reptains Brachiaria platyphylla, Brachiaria ruziziensis, Brachiaria plantaginea, Brachiaria decumbens, Brachiaria brizantha, Brachiaria humidicola, Brachiaria mutica, Cenchrus echinatus, Cenchrus pauciflorus, Eriochloa villosa, Pennisetum setosum, Chloris gayana, Chloris barbata, Eragrostis ilosa, Rhynchelitrum repens, Dactyloctenium aegyptium, Ischaemum rugosum, Oryza sativa, Paspalum notatum, Paspalum maritimum, Pennisetum clandestinum, Pennisetum setosum, Rottboellia cochinchinensis , Conzya species, Avena Sativa, Glycine max, Phaseolus vulgaris, Bidens Pilosa, Euphorbia hirta, Bidens subalternans, Zea mays, or combinations thereof.

[0066] In a preferred embodiment, the herbicidal combination is used to control weeds selected from the group comprising Gossypium hirsutum, Glycine max, Phaseolus vulgaris, Digitaria insularis, Eolium multiflorum, Avena sp., Bidens Pilosa, Euphorbia hirta, Bidens subalternans, Zea mays, Eleusine indica, Amaranthus quitensis, Sorghum halapense, or or combinations thereof.

[0067] In another embodiment, the combination of the present disclosure is used to control weeds in various agricultural crops. According to an embodiment, the present disclosure provides a method for controlling weeds in crops comprising rice, wheat, barley, rye, oat, sorghum, cotton, soybean, peanut, buckwheat, beet, rapeseed, sunflower, durum wheat, fall wheat, field corn, winter barley, cotton, fall barley, fallow, spring wheat, triticale, winter wheat, sugar cane, tobacco, etc.; vegetables; solanaceous vegetables such as eggplant, tomato, pimento, popper, potato, etc., cucurbit vegetables such as cucumber, pumpkin, zucchini, water melon, melon, squash, etc., cruciferous vegetables such as radish, white turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, cauliflower, etc., asteraceous vegetables such as burdock, crown daisy, artichoke, lettuce, etc., liliaceous vegetables such as green onion, onion, garlic, and asparagus, ammiaceous vegetables such as carrot, parsley, celery, parsnip, etc., chenopodiaceous vegetables such as spinach, Swiss chard, etc., lamiaceous vegetables such as Perilla frutescens, mint, basil, etc. strawberry, sweet potato, Dioscorea japonica, colocasia, etc., flowers, foliage plants, turf grasses, fruits: pome fruits such apple, pear, quince, etc. stone fleshy fruits such as peach, plum, nectarine, Prunus mume, cherry fruit, apricot, prune, etc., citrus fruits such as orange, lemon, rime, grapefruit, etc., nuts such as chestnuts, walnuts, hazelnuts, almond, pistachio, cashew nuts, macadamia nuts, etc. berries such as blueberry, cranberry, blackberry, raspberry, etc., grape, kaki fruit, olive, plum, banana, coffee, date palm, coconuts, etc., trees otter than fruit trees; tea, mulberry, flowering plant, trees such as ash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple, Quercus, poplar, Judas tree, liquidambar formosana, plane tree, zelkova. Japanese arborvitae, fir wood, hemlock, juniper, Pinus, Picea, and Taxus cuspidate, or combinations thereof.

[0068] In another embodiment, the herbicidal combination comprising a carbamate herbicide and at least one additional herbicide selected from PPO inhibitor herbicide provides about 30% to about 100% control of weeds.

[0069] According to an embodiment of the present disclosure, the herbicidal combination is usually applied to the unwanted plants / weeds by spraying on the leaves. Here, the application can be carried out using, for example, water as carrier by customary spraying techniques. In an embodiment, the application of the herbicidal combination may be done before, during and / or after, preferably before and / or after, the sowing of the crops. In an embodiment, the application of the herbicidal combination may be done on fallow field. In a preferred embodiment, the application of the herbicidal combination may be done to control the growth of weeds at the pre-emergence stage or the post-emergence stage. In a preferred embodiment, the application of the herbicidal combination may be done to control the growth of weeds close to the sowing stage of the crop.

[0070] According to an embodiment of the present disclosure, the herbicidal combination may be applied pre-or post-emergence of weeds, or together with the plant, or plant propagation material, or locus of a plant thereof. It is also possible to apply the herbicidal combination to a plant, or a plant propagation material, or a locus thereof or pre-treating a crop plant with the herbicidal combination.

[0071] In another embodiment, the herbicidal combination of the present disclosure may be applied in combination with agrochemical components such as fertilizers, macronutrients, micronutrients, biologic als, bio stimulants, plant extracts, synergists, or combinations thereof. In an embodiment, the macronutrients or a micronutrient is selected from the group comprising nitrogen, phosphorus, potassium, calcium, sulfur, magnesium, iron, zinc, copper, boron, manganese, chlorine, molybdenum, nickel, or combinations thereof.

[0072] In another embodiment, the additional herbicide may be admixed with an adjuvant or a bio-stimulant or a fertilizer compound such that said components may be tank mixed before spraying.

[0073] According to an embodiment, the herbicidal combination is applied from a predosage device, a knapsack sprayer, a spray tank, a spray plane, or an irrigation system, or a drone, or an spot spray system. Typically, the herbicidal combination is made up with water, buffer, and / or further auxiliaries to the desired application concentration and the ready-to-use spray liquor of the herbicidal combination is thus obtained.

[0074] In another embodiment, the herbicidal combination may be used for foliar application, application to a ground, or to the soil, or to a plant, or a locus or a plant propagation material, or combinations thereof. In another embodiment, the herbicidal combination can be used in agricultural lands such as fields, paddy fields, lawns and orchards or in non- agricultural lands, fallow fields, or for the purpose of chemical fallow application.

[0075] According to an embodiment, the present disclosure provides a process for preparing a herbicidal combination / compo sition comprising: a carbamate herbicide; at least one additional herbicide; and at least one agrochemically acceptable excipient thereof; wherein the process comprises mixing the carbamate herbicide, the additional herbicide and at least one agrochemically acceptable excipient homogenously to form the herbicidal combination / composition.

[0076] According to an embodiment, the present disclosure provides a process for preparing a herbicidal combination / composition comprising: a carbamate herbicide; at least one PPO inhibitor herbicide; and at least one agrochemically acceptable excipient thereof; wherein the process comprises mixing the carbamate herbicide, the additional herbicide and at least one agrochemically acceptable excipient homogenously to form the herbicidal combination / composition.

[0077] According to an embodiment, the present disclosure provides a process for preparing a herbicidal combination / composition comprising: asulam; at least one PPO inhibitor herbicide; and at least one agrochemically acceptable excipient thereof; wherein the process comprises mixing asulam, the PPO inhibitor herbicide and at least one agrochemically acceptable excipient homogenously to form the herbicidal combination / composition.

[0078] According to an embodiment, the various components of the herbicidal combination may be used individually or already partially or completely mixed with one or more to prepare the herbicidal combination. It is also possible for the components to be separately packaged and used as a component in a kit of parts. In one embodiment, the kits may include one or more of the components that are used to prepare the herbicidal combination. For examples, the kits may include active ingredients and / or at least one agrochemically acceptable excipient. One or more of the components may already be combined together or pre-formulated.

[0079] One or more of the components may already be combined together or preformulated. In those embodiments where more than two components are provided in a kit, the components may already be combined and as such are packaged in a single container such as a vial, bottle, can, pouch, bag and / or canister. In other embodiments, two or more components of a kit may be packaged separate from one another, i.e., they are not pre-formulated. As such, a kit may include one or more separate containers such as vials, cans, bottles, pouches, bags and / or canisters, each container containing a separate component of the herbicidal combination.

[0080] According to an embodiment, the kit of parts comprises: a carbamate herbicide; at least one additional herbicide; and optionally further comprises: instructions for use. According to an embodiment, the kit of parts comprises: a carbamate herbicide; at least one PPO inhibitor herbicide; and optionally further comprises: instructions for use.

[0081] According to an embodiment, the kit of parts comprises: asulam; at least one PPO inhibitor herbicide; and optionally further comprises: instructions for use.

[0082] In view of the above, it will be seen that the several advantages of the disclosure are achieved, and other advantageous results attained. Although the present disclosure has been disclosed in full, it will be understood that numerous additional modifications and variations could be made thereto without departing from the scope of the disclosure.

[0083] EXAMPLES:

[0084] The following active ingredient compounds were used in the present invention to prepare combinations / compositions of asulam with carfentrazone.

[0085] Example 1: Efficacy of Asulam and Carfentrazone on Goss pium hirsutum

[0086] The herbicidal combination comprising asulam and carfentrazone was evaluated to assess the efficacy of the combination for percentage control of Gossypium hirsutum on 28 and 35 days after application (DA-A). No phytotoxicity was observed on the crops. The results have been tabulated in Table 2. Table 2

[0087] It was observed that the herbicidal combination comprising asulam and carfentrazone showed enhanced efficacy in control of Gossypium hirsutum.

[0088] Example 2: Efficacy of Asulam and Carfentrazone on Glycine max

[0089] The herbicidal combination comprising asulam and carfentrazone was evaluated to assess the efficacy of the combination for percentage control of Glycine max on 28 and 35 days after application (DA-A). No phytotoxicity was observed on the crops. The results have been tabulated in Table 3.

[0090] Table 3

[0091] It was observed that the herbicidal combination comprising asulam and carfentrazone showed enhanced efficacy in control of Glycine max.

[0092] Example 3: Efficacy of Asulam and Carfentrazone on Phaseolus vulgaris

[0093] The herbicidal combination comprising asulam and carfentrazone was evaluated to assess the efficacy of the combination for percentage control of Phaseolus vulgaris on 21, 28 and 35 days after application (DA-A). No phytotoxicity was observed on the crops. The results have been tabulated in Table 4. Table 4

[0094] It was observed that the herbicidal combination comprising asulam and carfentrazone showed enhanced efficacy in control of Phaseolus vulgaris.

[0095] Example 4: Efficacy of Asulam and Carfentrazone on Digitaria insularis

[0096] The herbicidal combination comprising asulam and carfentrazone was evaluated to assess the efficacy of the combination for percentage control of Digitaria insularis on 14, 21 and 28 days after application (DA- A). No phytotoxicity was observed on the crops. The results have been tabulated in Table 5.

[0097] Table 5

[0098] It was observed that the herbicidal combination comprising asulam and carfentrazone showed enhanced efficacy in control of Digitaria insularis.

[0099] Example 5: Efficacy of Asulam and Carfentrazone on Lolium mullillorum

[0100] The herbicidal combination comprising asulam and carfentrazone was evaluated to assess the efficacy of the combination for percentage control of Lolium multiflorum on 21 and 35 days after application (DA- A). No phytotoxicity was observed on the crops. The results have been tabulated in Table 6. Table 6

[0101] It was observed that the herbicidal combination comprising asulam and carfentrazone showed enhanced efficacy in control of Lolium multiflorum.

[0102] Example 6: Efficacy of Asulam and Carfentrazone on Avena sp.

[0103] The herbicidal combination comprising asulam and carfentrazone was evaluated to assess the efficacy of the combination for percentage control of Avena sp. on 21 and 35 days after application (DA-A). No phytotoxicity was observed on the crops. The results have been tabulated in Table 7.

[0104] Table 7

[0105] It was observed that the herbicidal combination comprising asulam and carfentrazone showed enhanced efficacy in control of Avena sp.

[0106] Example 7: Efficacy of Asulam and Saflufenacil for control of Bidens pilosa

[0107] The percentage (%) control of weeds was evaluated to assess the efficacy of the combination comprising asulam and saflufenacil and the same has been disclosed in Table 8. Table 8

[0108] The effect of application of asulam along with saflufenacil was observed on the growth of Bidens pilosa weed at 14 DAA (days after application).

[0109] Example 8: Efficacy of Asulam and Tiafenacil for control of Glycine max weed The percentage (%) control of weeds was evaluated to assess the efficacy of the combination comprising asulam and tiafenacil and the same has been disclosed in Table 9.

[0110] Table 9

[0111] The effect of application of asulam along with tiafenacil was observed on the growth of Glycine max at 14 DAA (days after application).

[0112] Example 9: Control of Asulam + Fomesafen on Euphorbia hirta

[0113] The herbicidal combination comprising asulam and fomesafen was evaluated to assess the efficacy of the combination for percentage control of Euphorbia hirta at 7, 14, 21, 28 and 35 days after application (DAA). No phytotoxicity was observed on the crops. The results have been tabulated in Table 10. Table 10

[0114] E* - Expected

[0115] O* - Observed

[0116] It was observed that the herbicidal combination comprising asulam and fomesafen showed enhanced efficacy in control of Euphorbia hirta.

[0117] Example 10: Control of Asulam + Fomesafen on Bidens subalternans

[0118] The herbicidal combination comprising asulam and fomesafen was evaluated to assess the efficacy of the combination for percentage control of Bidens subalternans at 21 (DAA). No phytotoxicity was observed on the crops. The results have been tabulated in Table 11.

[0119] Table 11

[0120] It was observed that the herbicidal combination comprising asulam and fomesafen showed enhanced efficacy in control of Bidens subalternans. Example 11: Control of Asulam + Fomesafen on Digitaria insularis

[0121] The herbicidal combination comprising asulam and fomesafen was evaluated to assess the efficacy of the combination for percentage control of Digitaria insularis at 7, 28 and 35 days after application (DAA). No phytotoxicity was observed on the

[0122] 5 crops. The results have been tabulated in Table 12.

[0123] Table 12

[0124] It was observed that the herbicidal combination comprising asulam and fomesafen showed enhanced efficacy in control of Euphorbia hirta.

[0125] 10

[0126] Example 12: Efficacy of Asulam and Flumioxazin on Glycine max

[0127] The herbicidal combination comprising asulam and flumioxazin was evaluated to assess the efficacy of the combination for percentage control of Glycine max on 21 and 35 days after application (DAA). No phytotoxicity was observed on the crops.

[0128] 15 The results have been tabulated in Table 13.

[0129] Table 13

[0130] Therefore, enhanced efficacy was observed in the control of Glycine max by application of herbicidal combination comprising asulam and flumioxazin.

[0131] Example 13: Efficacy of Asulam and Flumioxazin on Phaseolus vulgaris

[0132] The herbicidal combination comprising asulam and flumioxazin was evaluated to assess the efficacy of the combination for percentage control of Phaseolus vulgaris on 21 and 28 DAA. No phytotoxicity was observed on the crops. The results have been tabulated in Table 14.

[0133] Table 14

[0134] Therefore, enhanced efficacy was observed in the control of Phaseolus vulgaris by application of herbicidal combination comprising asulam and flumioxazin.

[0135] Example 14: Efficacy of Asulam and Flumioxazin on Lolium multiflorum

[0136] The herbicidal combination comprising asulam and flumioxazin was evaluated to assess the efficacy of the combination for percentage control of Lolium multiflorum on 21, 28 and 35 DAA. No phytotoxicity was observed on the crops. The results have been tabulated in Table 15.

[0137] Table 15

[0138] Therefore, enhanced efficacy was observed in the control of Lolium multiflorum by application of herbicidal combination comprising asulam and flumioxazin.

[0139] Example 15: Efficacy of Asulam and Flumioxazin on Avena sp. The herbicidal combination comprising asulam and flumioxazin was evaluated to assess the efficacy of the combination for percentage control of Avena sp. on 21 and 28 DAA. No phytotoxicity was observed on the crops. The results have been tabulated in Table 16.

[0140] Table 16

[0141] Therefore, enhanced efficacy was observed in the control of Avena sp. by application of herbicidal combination comprising asulam and flumioxazin.

[0142] Example 16: Efficacy of Asulam and Flumioxazin on Zea mays

[0143] The herbicidal combination comprising asulam and flumioxazin was evaluated to assess the efficacy of the combination for percentage control of Zea mays on 21 and 28 DAA. No phytotoxicity was observed on the crops. The results have been tabulated in Table 17.

[0144] Table 17

[0145] Therefore, enhanced efficacy was observed in the control of Zea mays by application of herbicidal combination comprising asulam and flumioxazin. Example 17: Control of Asulam + Epyrifenacil on Eleusine indica

[0146] The herbicidal combination comprising asulam and epyrifenacil was evaluated to assess the efficacy of the combination for percentage control of Eleusine indica at 7, 14, 21, 28, and 35 (DAA). No phytotoxicity was observed on the crops. The

[0147] 5 results have been tabulated in Table 18.

[0148] Table 18

[0149]

[0150] *E=Expected

[0151] *O=Observed

[0152] It was observed that the herbicidal combination comprising asulam and epyrifenacil showed enhanced efficacy in control of Eleusine indica.

[0153] 5

[0154] Example 18: Control of Asulam + Epyrifenacil on Amaranthus guilensis

[0155] The herbicidal combination comprising asulam and epyrifenacil was evaluated to assess the efficacy of the combination for percentage control of Amaranthus quitensis at 7, 14, 21, 28, and 35 (DAA). No phytotoxicity was observed on the 0 crops. The results have been tabulated in Table 19.

[0156] Table 19

[0157] *E=Expected

[0158] *O=Observed

[0159] It was observed that the herbicidal combination comprising asulam and epyrifenacil showed enhanced efficacy in control of Amaranthus quitensis.

[0160] 5

[0161] Example 19: Control of Asulam + Epyrifenacil on Sorgum halapense

[0162] The herbicidal combination comprising asulam and epyrifenacil was evaluated to assess the efficacy of the combination for percentage control of Sorghum halapense at 7, 14 and 21 (DAA). No phytotoxicity was observed on the crops. The results 0 have been tabulated in Table 20.

[0163] Table 20

[0164] *E=Expected

[0165] *O=Observed

[0166] It was observed that the herbicidal combination comprising asulam and epyrifenacil 5 showed enhanced efficacy in control of Sorghum halapense.

Claims

CLAIMS:

1. A herbicidal combination comprising: a carbamate herbicide; and at least one PPO inhibitor herbicide.

2. The combination as claimed in claim 1, wherein the carbamate herbicide is asulam.

3. The combination as claimed in claim 1, wherein the PPO inhibitor herbicide is selected from the group comprising carfentrazone-ethyl, acifluorfen, azafenidin, bifenox, butafenacil, cinidonethyl, epyrifenacil, flumicloracpentyl, flumioxazin, fluthiacetmethyl, fomesafen, lactofen, oxadiargyl, oxadiazon, oxyfluorfen, pentoxazone, pyraclonil, pyraflufenethyl, saflufenacil, sulfentrazone, tiafenacil, trifludimoxazin, or combinations thereof.

4. The combination as claimed in claim 3, wherein the PPO inhibitor herbicide is selected from the group comprising carfentrazone-ethyl, flumioxazin, fomesafen, saflufenacil, tiafenacil, epyrifenacil, or combinations thereof.

5. The combination as claimed in claim 1, wherein asulam and the PPO inhibitor herbicide are present in a weight ratio from about 1:25 to about 25: 1.

6. Use of the herbicidal combination as claimed in claim 1, for controlling weeds by concurrent or subsequent or sequential application.

7. A method for controlling weeds, wherein the method comprises applying to a plant or a locus thereof, an effective amount of a herbicidal combination comprising: a carbamate herbicide; and at least one PPO inhibitor herbicide.

8. The method as claimed in claim 7, wherein the carbamate herbicide is asulam.

9. The method as claimed in claim 7, wherein the PPO inhibitor herbicide is selected from the group comprising carfentrazone-ethyl, flumioxazin, fomesafen, saflufenacil, tiafenacil, epyrifenacil, or combinations thereof.

10. The method as claimed in claim 7, wherein the carbamate herbicide is applied at an application rate from about 1 g a.i. / ha to about 2000 g a.i. / ha and the PPO inhibitor herbicide is applied at an application rate from about 1 g a.i. / ha to about 400 g a.i. / ha.

11. The method as claimed in claim 7, wherein the weeds are selected from the group comprising Gossypium hirsutum, Glycine max, Phaseolus vulgaris, Digitaria insularis, Lolium multiflorum, Avena sp., Bidens Pilosa, Euphorbia hirta, Bidens subalternans , Zea mays, Eleusine indica, Amaranthus quitensis, Sorghum halapense, or combinations thereof.

12. The method as claimed in claim 7, wherein the herbicidal combination provides about 30% to about 100% control of weeds.

13. A herbicidal composition comprising: a carbamate herbicide; at least one PPO inhibitor herbicide; and at least one agrochemically acceptable excipient.

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