Container plate alignment for acoustic droplet ejection

The system addresses misalignment in acoustic droplet ejection by using a flyby survey to adjust the transducer's position based on reference well locations, ensuring precise droplet ejection into target wells.

WO2026117585A1PCT designated stage Publication Date: 2026-06-04LABCYTE INC
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
LABCYTE INC
Filing Date
2025-11-25
Publication Date
2026-06-04

AI Technical Summary

Technical Problem

Acoustic droplet ejection systems face misalignment issues with container wells, leading to misdirected droplets and reduced accuracy, especially in densely packed container plates, causing droplets to strike well walls or miss the target entirely.

Method used

A method and system that uses a flyby survey to ascertain the locations of reference wells on a container plate, calculating skew and center displacement to adjust the transducer's position relative to the container plate, ensuring precise alignment and ejection of droplets into the intended target.

Benefits of technology

The system effectively corrects misalignments by mechanically adjusting the container plate position and controlling the transducer's movement, achieving high precision in droplet ejection with minimal errors and improved targeting accuracy.

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Abstract

An acoustic droplet ejection (ADE) system is operated such that a container plate with multiple wells is secured relative to an acoustic transducer on a container plate seat. Locations of a subset of the wells identified as reference wells are ascertained via a flyby survey, allowing a skew and a center displacement of the container plate to be determined relative to the container plate seat. The acoustic transducer is then translated to a defined transfer location corresponding to one of the wells, based on the known center displacement and skew of the container plate, and a toneburst is generated to eject a fluid droplet.
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Citation Information

Patent Citations

  • US10787670B2

  • US20190302063A1

  • US20040102742A1

  • WO2015108807A1