Lipid degraders to trigger ferroptosis in cancer

Fentomycin, a chimeric small molecule targeting lysosomes, addresses the challenge of treating CSCs and DTP cells by inducing ferroptosis through iron-catalyzed lipid oxidation, effectively inhibiting tumor growth and metastasis.

AU2025213523A1Pending Publication Date: 2026-07-16INSTITUT CURIE +3
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Patent Information

Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
INSTITUT CURIE
Filing Date
2025-01-27
Publication Date
2026-07-16

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Abstract

The present invention relates to a conjugate for use in the treatment of cancer, the conjugate comprising a first moiety A selected from metal chelating agents, a second moiety B selected from lysosomotropic agents; and a linker L that binds moieties A and B together. The invention also relates to their use in the pharmaceutical field, in particular in a method for the treatment of cancer.
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