Propionic acid derivatives and methods of use thereof

Abstract

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

Description

PROPIONIC ACID DERIVATIVES AND METHODS OF USE THEREOF Cross-Reference to Related Applications This international application claims benefit of priority of pending non-provisional application U.S. Serial No. 15 / 497,414, filed April 26, 2017. BACKGROUND OF THE INVENTION Field of the Invention The present invention relates generally to field of medicinal chemistry and therapeutic compounds. More specifically, the present invention relates to derivatives of propionic acid as integrin inhibitors. Description of the Related art Integrins are a large family of cell adhesion protein molecules that are expressed on numerous cells and which mediate a variety of cell-cell and cell-matrix interactions. Accordingly, the regulation of a number of physiological processes, such as, and including, cell adhesion, migration, signaling, survival and differentiation are known to involve these molecules. Each Integrin consists of a non-covalently associated alpha and beta transmembrane heterodimer subunit, with 18 different alpha and 8 different beta units being identified to date. Integrins function as conduits for signaling that occurs between the inside of cells and their external environment. Through ligand interactions, Integrins sense the extracellular environment, activate, and then relay this information to the inside of the cell. This process is fundamental to the functional interaction of cells to various tissues such as and including the vascular endothelium, bone marrow stromal cells, some tumor cells and the gastrointestinal mucosal. Additionally, as Integrins are widely expressed on leukocytes, especially T-cells, and thus are critical players in the regulation of the pathophysiologic processes of inflammation and autoimmune disease. To date, approximately 24 different integrin molecules have been identified. Of these, the integrins derived from the alpha 4 subunit are associated with disease states of current unmet medical need. Two such integrins are alpha 4 beta 1 (also called VLA-4 for very late antigen-4) and alpha 4 beta 7 (also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1)). These two integrins are the primary pathogenic targets of this patent application. There are three main types of white blood cells: granulocytes, monocytes and lymphocytes. The alpha 4 integrins are expressed on the surface of monocytes, lymphocytes and two subclasses of granulocytes: eosinophils and basophils. These proteins play a key role in cell adhesion through their ability to recognize and bind to other cell surface portions of other proteins such as vascular cell adhesion molecule 1 (VCAM-I), fibronectin, or other proteins associated with the endothelial cells that line the interior wall of capillaries. For example, following infection or damage of tissue surrounding a capillary, endothelial cells express a series of adhesion molecules, including VCAM-I, that are critical for binding the white blood cells that are necessary for fighting infection. In a similar fashion, alpha 4 beta 7, critical for homing to intestinal mucosa, is induced during T cell activation in Peyer's patches or mesenteric lymph nodes. Some of the disease conditions that currently are, and in the future might be, treated by the inhibition of the alpha 4 integrins include, but is not limited to, hematopoietic stem cell transplant therapy, sickle cell disease, dry eye, atherosclerosis, rheumatoid arthritis, asthma, allergy, multiple sclerosis, lupus, inflammatory bowel disease, graft rejection, contact hypersensitivity, stroke, pulmonary arterial hypertension and diabetes. It has been suggested that cell adhesion involving alpha4 beta1 may be involved in the metastasis and survival of certain cancer cells. Inhibitors of alpha4 beta1 binding may, therefore, also be useful in the treatment of some forms of cancer. The isolation and purification of a peptide which inhibits the binding of alpha 4 beta 1 to a protein is disclosed in US. Pat. No.5, 510,332. Peptides which inhibit binding are disclosed in WO 95 / 15973, EP 0 341915, EP 0 422 938 A1, US. Pat. No. 5,192,746 and WO 96 / 06108. Novel small molecule compounds which are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies are disclosed in WO 96 / 22966, WO 98 / 04247 and US 2004 / 0234624 A1 (WO 98 / 04913), WO2005014534 A1, US 7,812,03, 6,972,296, US 6,723,711, US 6,262,084. It is the objective of this invention to provide novel small molecule compounds which are antagonists of the action of alpha 4 beta 1 and alpha 4 beta 7 binding and their corresponding pharmaceutical compositions which include such novel compounds. SUMMARY OF THE INVENTION The present invention is directed to a compound of formula I having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I) In these compounds R1 may be [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] or R2 and R3 may be independently hydrogen or C1-4 alkyl; R4 may be H or C1-4 alkyl; R5 may be phenyl, aryl, heterocyclyl or aralkyl which is substituted with one or more of hydrogen, C1-4 alkyl, alkoxy, aryloxy, oxo, halogen, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, - <semantics>OCF2CF2H<annotation encoding="application / x-tex">OCF_2CF_2H< / annotation>< / semantics>, <semantics>−O(C3−6<annotation encoding="application / x-tex">-O(C_{3-6}< / annotation>< / semantics> cycloalkyl), <semantics>−OCH2CF3<annotation encoding="application / x-tex">-OCH_2CF_3< / annotation>< / semantics>, thioalkoxy, dialkylamino, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl or haloalkyl; R6 may be C1-4 alkyl, halogen, phenyl, aryl or heterocyclyl which is substituted with one or more of hydrogen, C1-4 alkyl, alkoxy, aryl, aryloxy, halogen, oxo, acetyl, haloalkoxy, - CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, cycloalkyl or haloalkyl; R7 may be H or C1-4 alkyl; R8, R9 and R10 may be independently hydrogen, halogen, C1-4 alkyl, C3-6 cycloalkyl, or hydroxyl. The compounds encompass pharmaceutically acceptable salt or stereoisomers thereof. The present invention is directed to a related compound of formula I having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I) In these compounds, R1 may be [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] ; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] ; or • R2 and R3 may be independently hydrogen or methyl; R4 may be hydrogen; methyl, ethyl or t-butyl; R5 may be phenyl, aryl, heterocyclyl or aralkyl which is substituted with one or more of hydrogen, C1-4 alkyl, alkoxy, aryloxy, oxo, halogen, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; R6 may be C1-4 alkyl, halogen, phenyl, aryl, or heterocyclyl which is substituted with one or more of hydrogen, C1-4 alkyl, alkoxy, aryl, aryloxy, halogen, oxo, acetyl, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; R7 may be H; methyl or ethyl; R8 and R9 may independently hydrogen or methyl and R10 may be hydroxyl. The compounds encompass pharmaceutically acceptable salt or stereoisomers thereof. The present invention also is directed to pharmaceutical composition, comprising at least one compound as described herein and one or more pharmaceutically acceptable carriers. The present invention is directed further to a method for treating a pathophysiological condition mediated by <semantics>α4<annotation encoding="application / x-tex">\alpha 4< / annotation>< / semantics> integrins i.e. <semantics>α4β1<annotation encoding="application / x-tex">\alpha 4\beta 1< / annotation>< / semantics>, <semantics>α4β7<annotation encoding="application / x-tex">\alpha 4\beta 7< / annotation>< / semantics> or mixed <semantics>α4β1<annotation encoding="application / x-tex">\alpha 4\beta 1< / annotation>< / semantics> and <semantics>α4β7<annotation encoding="application / x-tex">\alpha 4\beta 7< / annotation>< / semantics> integrins in a subject in need of such treatment. The method comprises administering a pharmacologically effective amount of the pharmaceutical composition as described herein. The present invention also is directed to a method for inhibiting integrin binding in a cell associated with a pathophysiological condition. The method comprises contacting the cell with one or more compounds as described herein. In an embodiment, there is provided a compound of formula I having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I) wherein R1 is [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] , • [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] or j <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics> and <semantics>R3<annotation encoding="application / x-tex">R^3< / annotation>< / semantics> are independently hydrogen or <semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics> alkyl; <semantics>R4<annotation encoding="application / x-tex">R^4< / annotation>< / semantics> is H or <semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics> alkyl; R5 is phenyl, or aryl, any of which is substituted with one or more of C1-4 alkyl, alkoxy, oxo, halogen, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; R6 is phenyl, or aryl, any of which is substituted with one or more of C1-4 alkyl, alkoxy, halogen, oxo, acetyl, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; <semantics>R7<annotation encoding="application / x-tex">R^7< / annotation>< / semantics> is H or <semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics> alkyl; R8, and R9 are independently hydrogen, C1-4 alkyl, or hydroxyl; and R10 is hydroxyl; or a pharmaceutically acceptable salt or stereoisomers thereof. In another embodiment, there is provided a compound of formula I having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I) wherein R1 is [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] , • [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] or <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics> and <semantics>R3<annotation encoding="application / x-tex">R^3< / annotation>< / semantics> are hydrogen; R4 is hydrogen; methyl, ethyl or t-butyl; R5 is phenyl, or aryl, any of which is substituted with one or more of C1-4 alkyl, alkoxy, oxo, halogen, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; R6 is phenyl, or aryl, any of which is substituted with one or more of hydrogen, C1-4 alkyl, alkoxy, halogen, oxo, acetyl, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, - OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; R7 is hydrogen, methyl or ethyl; and R8 and R9 are independently hydrogen or methyl; or a pharmaceutically acceptable salt or stereoisomers thereof. [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] • [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] ethyl (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin- 2-yl) phenyl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridazin-3-yl)phenyl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylpyridin-3-yl)propanoate; (S)-ethyl 3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; tert-butyl (S)-3-(biphenyl-4-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6'- methoxy pyridin-2-yl)phenyl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxy biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl) ureido)propanoate; ethyl 3-(3-bromophenyl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(biphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; 3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(2-oxo-3- phenyl pyridin-1(2H)-yl)phenyl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoic acid; (S)-3-(2'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(6-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-3-yl)propanoic acid; (S)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl biphenyl-3-yl)propanoic acid; 3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(2',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin-3- yl) phenyl)propanoic acid; (S)-3-(3',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoromethyl) biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; (S)-3-(3',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(2',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(2',3'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-oxo-1-phenyl- 1,6-dihydropyridin-3-yl)propanoic acid; (S)-3-(2',6'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; (S)-3-(2',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; 3-(4'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; 3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; 3-(2'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethyl) biphenyl-3-yl)propanoic acid; (S)-3-(5,6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridin-3-yl)phenyl)propanoic acid; (S)-3-(2',5'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyrimidin-5- yl)phenyl) propanoic acid; (S)-3-(2',6'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylfuran-2-yl) propanoic acid; (S)-3-(3-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; 3-(3'-chloro-4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; 3-(2',3'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2′,4′<annotation encoding="application / x-tex">(2',4'< / annotation>< / semantics>-difluorobiphenyl-3-yl)-3-<semantics>(3−(4−hydroxy−1−methyl−2−oxo−1,2−dihydropyridin−<annotation encoding="application / x-tex">(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-< / annotation>< / semantics> 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 2'-methylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5'-methoxy- 2'-methylbiphenyl-3-yl)propanoic acid; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(2,2,2-trifluoro ethoxy)biphenyl-3-yl)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2′<annotation encoding="application / x-tex">(2'< / annotation>< / semantics>-ethylbiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-2-oxo-1,2-dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3',4'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(2',3'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(4'-fluoro-3'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(1-phenyl- 1H-pyrrol-2-yl)propanoic acid; (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2- methylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; 3-(5'-chloro-2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(2',3'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido)propanoic acid; (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; (S)-3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridin-3-yl)phenyl)propanoic acid; (S)-3-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; 3-(2',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-2,5,6,7-tetrahydro- 1H-cyclopenta[b]pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-4-methyl-5-oxo-4,5- dihydrothieno[3,2-b] pyridin-6-yl)ureido)propanoic acid; (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(1H-indazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(2',4'-difluoro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenylthiophen-2-yl) propanoic acid; (S)-3-(3-(1-ethyl-1H-indol-6-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3−(1H−pyrazol−1−yl)phenyl)<annotation encoding="application / x-tex">(3-(1H-pyrazol-1-yl)phenyl)< / annotation>< / semantics>-3-<semantics>(3−(4−hydroxy−1−methyl−2−oxo−1,2−dihydropyridin−<annotation encoding="application / x-tex">(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-< / annotation>< / semantics> 3-yl) ureido)propanoic acid; (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin -3-yl)ureido)propanoic acid; (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; 3-(2',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8- naphthyridin -3-yl)ureido)propanoic acid; (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-(3- methoxyphenyl) thiophen-2-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxybiphenyl-3-yl) propanoic acid; (S)-3-(4-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiophen-2- yl) phenyl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid; (S)-3-(3'-chloro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy-4'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(2',6'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(5-chlorothiophen-2-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(4- methylthiophen-3-yl)phenyl)propanoic acid; (S)-3-(2',4'-difluoro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-6- methyl biphenyl-3-yl)propanoic acid; (S)-3-(4-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin -3-yl)ureido)propanoic acid; (S)-3-(3-(1H-pyrrol-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trimethylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trifluorobiphenyl-3-yl)propanoic acid; (S)-3-(6-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(1-methyl-1H- pyrazol-4-yl)phenyl)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(5-hydroxy-2-methyl-3-oxo-2,3- dihydropyridazin-4-yl) ureido)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3'-chloro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3′<annotation encoding="application / x-tex">(3'< / annotation>< / semantics>-chlorobiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxybiphenyl-3-yl) propanoic acid; (S)-3-(3-(furan-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(5-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- methoxyphenyl) thiophen-2-yl)propanoic acid; (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 6-methyl biphenyl-3-yl)propanoic acid 1; (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- phenylpyridin-2-yl) propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethylbiphenyl-3-yl)propanoic acid; (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methyl-3'- (trifluoromethoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid; (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-5- methyl biphenyl-3-yl)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-methyl-[2,3'- bithiophen]-5-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-methyl- [2,3'-bithiophen]-5-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 5-methyl biphenyl-3-yl)propanoic acid; (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin -3-yl)ureido)propanoic acid; (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluorobiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluoro biphenyl-3-yl)propanoic acid; (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethyl biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl) propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoic acid; (S)-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- (trifluoromethoxy) phenyl)thiophen-2-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid; (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(5-(3,5-dimethylisoxazol-4-yl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(2-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylthiophen-2-yl) propanoic acid; (S)-3-(5-(2,5-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-4-yl) propanoic acid; (S)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl)ureido)-3-(5- methoxybiphenyl-3-yl) propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-<semantics>(5<annotation encoding="application / x-tex">(5< / annotation>< / semantics>- (trifluoromethyl) biphenyl-3-yl)propanoic acid; (S)-3-(5-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(5-(3-fluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'-methyl-6- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; 3-(3'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; 3-(4'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenylthiophen-2-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylthiophen-2-yl)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6- yl)ureido) propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiazol-2- yl)phenyl) propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluorobiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-6- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 6-(trifluoromethoxy)biphenyl-3-yl)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-4-yl)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin-2- yl)phenyl) propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridazin-3-yl)phenyl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylpyridin-3-yl) propanoic acid; (S)-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(biphenyl-4-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido) propanoic acid; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylfuran-2-yl)propanoate; sodium (S)-3-(3-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-3-(3-(1,5-dimethyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate; sodium 3-(3'-chloro-4'-fluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium 3-(2',3'-dichlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-2'-methylbiphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5'- methoxy-2'-methylbiphenyl-3-yl)propanoate; sodium 3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(2,2,2- trifluoro ethoxy)biphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- ethyl biphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- fluoro biphenyl-3-yl)propanoate; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-oxido-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3',4'- dimethyl biphenyl-3-yl)propanoate; sodium (S)-3-(2',3'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- fluoro-3'-methylbiphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(1- phenyl-1H-pyrrol-2-yl)propanoate; sodium (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2- methyl biphenyl-3-yl)propanoate; sodium (S)-3-(3'-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; sodium (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium 3-(5'-chloro-2',4'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(2',3'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoate; sodium (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; sodium (S)-3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; sodium (S)-3-(3-(6-methoxypyridin-3-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoro methoxy)biphenyl-3-yl)propanoate; sodium 3-(2',4'-dichlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoro methoxy)biphenyl-3-yl)propanoate; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-2,5,6,7- tetrahydro-1H-cyclopenta[b]pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoro methoxy)biphenyl-3-yl)propanoate; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-methyl-7-oxido-5-oxo-4,5- dihydrothieno[3,2-b]pyridin-6-yl)ureido)propanoate; sodium (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1H-indazol-1-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(2',4'-difluoro-6-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo- 1,2-dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenyl thiophen-2-yl)propanoate; sodium (S)-3-(3-(1-ethyl-1H-indol-6-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1H-pyrazol-1-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium 3-(2',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydro- 1,8-naphthyridin-3-yl)ureido)propanoate; sodium (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(4-(3-methoxyphenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(6-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(4-(3-chlorophenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-ethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (thiophen-2-yl) phenyl)propanoate; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] Other and further aspects, features, benefits, and advantages of the present invention will be apparent from the following description of the presently preferred embodiments of the invention given for the purpose of disclosure. DETAILED DESCRIPTION OF THE INVENTION As used herein in the specification, "a" or "an" may mean one or more. As used herein in the claim(s), when used in conjunction with the word "comprising", the words "a" or "an" may mean one or more than one. As used herein "another" or "other" may mean at least a second or more of the same or different claim element or components thereof. Similarly, the word "or" is intended to include "and" unless the context clearly indicates otherwise. "Comprise" means "include." As used herein, the term "about" refers to a numeric value, including, for example, whole numbers, fractions, and percentages, whether or not explicitly indicated. The term "about" generally refers to a range of numerical values (e.g., + / - 5-10% of the recited value) that one of ordinary skill in the art would consider equivalent to the recited value (e.g., having the same function or result). In some instances, the term "about" may include numerical values that are rounded to the nearest significant figure. The term "nd" is intended to mean not yet determined The term alpha 4 integrin(s) (aka <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4-integrin(s)) refers to the class of integrin dimer molecules composed of the alpha 4 subunit coupled with another subunit normally referred to as a beta (<semantics>▫<annotation encoding="application / x-tex">\square< / annotation>< / semantics>) subunit. Typical, but not exclusive, examples are <semantics>α4β1<annotation encoding="application / x-tex">\alpha 4\beta 1< / annotation>< / semantics> and <semantics>α4β7<annotation encoding="application / x-tex">\alpha 4\beta 7< / annotation>< / semantics>. The term "alkyl" as used herein, alone or in combination, refers to C1 -C12 straight or branched, substituted or unsubstituted saturated chain radicals derived from saturated hydrocarbons by the removal of one hydrogen atom, unless the term alkyl is preceded by a <semantics>Cx<annotation encoding="application / x-tex">C_x< / annotation>< / semantics>-<semantics>Cy<annotation encoding="application / x-tex">C_y< / annotation>< / semantics> designation. Representative examples of alkyl groups include methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, and tert-butyl among others. The term "alkenyl" as used herein, alone or in combination, refers to a substituted or unsubstituted straight-chain or substituted or unsubstituted branched-chain alkenyl radical containing from 2 to 10 carbon atoms. Examples of such radicals include, but are not limited to, ethenyl, E- and Z-pentenyl, decenyl and the like. The term "alkynyl" as used herein, alone or in combination, refers to a substituted or unsubstituted straight or substituted or unsubstituted branched chain alkynyl radical containing from 2 to 10 carbon atoms. Examples of such radicals include, but are not limited to ethynyl, propynyl, propargyl, butynyl, hexynyl, decynyl and the like. The term "cycloalkyl" as used herein refers to an aliphatic ring system having 3 to 10 carbon atoms and 1 to 3 rings, including, but not limited to cyclopropyl, cyclopentyl, cyclohexyl, norbornyl, and adamantyl among others. Cycloalkyl groups can be unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, haloalkyl, alkoxy, thioalkoxy, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, alkoxycarbonyl and carboxamide. "Cycloalkyl" includes cis or trans forms. Furthermore, the substituents may either be in endo or exo positions in the bridged bicyclic systems. The term "halo" or "halogen" as used herein refers to I, Br, Cl or F. The term "haloalkyl" as used herein refers to C₁-C₄ alkyl radical, to which is appended at least one halogen substituent, for example chloromethyl, fluoroethyl, difluoromethyl, trifluoromethyl and pentafluoroethyl among others. The term "alkoxy" as used herein, alone or in combination, refers to an alkyl ether radical, wherein the term "alkyl" is as defined above. Examples of suitable alkyl ether radicals include, but are not limited to, methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy, tert-butoxy and the like. The term "haloalkoxy" as used herein, alone or in combination, refers to an haloalkyl ether radical, wherein the term "haloalkyl" is as defined above. Examples of suitable haloalkyl ether radicals include, but are not limited to, chloromethoxy, trifluoromethoxy, difluoromethoxy, trifluoroethoxy and the like The term "thioalkoxy" refers to a thioether radical of formula alkyl--S--, wherein "alkyl" is as defined above. The term "dialkylamino" as used herein refers to Rf Rg N-- wherein Rf and Rg are independently selected from C1-C4 alkyl, for example diethylamino, and methyl propylamino, among others. The term "aryl" as used herein alone refers to a substituted or unsubstituted carbocyclic aromatic group having about 6 to 12 carbon atoms such as phenyl, naphthyl, indenyl, indanyl, azulenyl, fluorenyl and anthracenyl and the like. "Aralkyl" and "alkylaryl" employ the term "alkyl" as defined above. Rings may be multiply substituted. The term "biaryl" as used herein, alone or in combination, refers to a radical of formula aryl-aryl, wherein the term "aryl" is as defined above. The term "aralkyl" as used herein, alone or in combination, refers to an aryl substituted alkyl radical, wherein the terms "alkyl" and "aryl" are as defined above. Examples of suitable aralkyl radicals include, but are not limited to, phenylmethyl, phenethyl, phenylhexyl, diphenylmethyl, pyridylmethyl, tetrazolyl methyl, furylmethyl, imidazolyl methyl, indolylmethyl, thienylpropyl and the like. The term "aryloxy" as used herein, alone or in combination, refers to an aryl ether radical, wherein the term "aryl" is as defined above. The term "benzyl" as used herein refers to C6H5CH2 --. The term "heterocyclyl" as used herein, alone or in combination, refers to a non- aromatic 3- to 10-membered ring containing at least one endocyclic N, O, or S atom. The heterocycle may be optionally aryl-fused. The heterocycle may also optionally be substituted with at least one substituent which is independently selected from the group consisting of hydrogen, halogen, hydroxyl, amino, nitro, trifluoromethyl, trifluoromethoxy, trifluoroethoxy, alkyl, alkoxy, aralkyl, alkenyl, alkynyl, aryl, cyano, carboxy, carboalkoxy, carboxyalkyl, oxo, acetyl, arylsulfonyl and aralkylaminocarbonyl among others. The term "heteroaryl" as used herein refers to aromatic moieties containing one or more heteroatoms (e.g., N, O, S, or the like) as part of the ring structure and having in the range of 5 up to 14 total atoms in the ring structure, i.e., carbon atoms and heteroatoms such as furyl, thienyl, pyridyl, dihydropyridyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, 2- pyrazolinyl, pyrazolidinyl, isoxazolyl, isothiazolyl, 1,2,3-oxadiazolyl, 1,2,3-triazolyl, 1,3,4- thiadiazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, 1,3,5-triazinyl, 1,3,5-trithianyl, indolizinyl, indolyl, isoindolyl, 3H-indolyl, indolinyl, benzo[b]furanyl, 2,3-dihydrobenzofuranyl, benzo[b]thiophenyl, benzodioxolyl, 1H-indazolyl, benzimidazolyl, benzthiazolyl, purinyl, 4H- quinolizinyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, 1,8-naphthridinyl, pteridinyl, carbazolyl, acridinyl, phenazinyl, phenothiazinyl, phenoxyazinyl, pyrazolo[l,5- c]triazinyl and the like. "Substituted heteroaryl" refers to heteroaryl groups further bearing one or more substituents. The term "stereoisomer" as used herein refers to a compound made up of the same atoms bonded by the same bonds but having different three-dimensional structures which are not interchangeable. The three-dimensional structures are called configurations The term "pharmaceutically acceptable salts" as used herein of a compound is meant salts which are pharmaceutically acceptable as defined herein and which have the desired pharmacological action of the parent compound. Such salts comprise the addition salts of pharmaceutically acceptable bases formed when an acid proton contained in the parent compound is either replaced by a metal ion e.g. an alkaline metal ion, an alkaline-earth metal ion or aluminium ion; or coordinated with a pharmaceutically acceptable organic or inorganic base. Acceptable organic bases include diethanolamine, ethanolamine, N-methylglucamine, triethanolamine, tromethamine and the like. Acceptable inorganic bases include aluminium hydroxide, calcium hydroxide, potassium hydroxide, sodium carbonate and sodium hydroxide. Especially, sodium is preferred and it can be either the mono sodium or di-sodium form or a mixture thereof. The term "effective amount" as used herein refers to generally an amount effective to accomplish the intended purpose, e.g., a pharmacologically effective amount. However, the amount can be less than that amount when a plurality of the compositions are to be administered, i.e., the total effective amount can be administered in cumulative dosage units. The amount of active agent can also be more than the effective amount when the composition provides sustained release of the pharmacologically active agent. The total amount of a pharmacologically active agent to be used can be determined by methods known to those skilled in the art. However, because the compositions may deliver the pharmacologically active agent more efficiently than prior compositions, less amounts of active agent than those used in prior dosage unit forms or delivery systems can be administered to a subject while still achieving the same blood levels and / or therapeutic effects. As used herein, the term "sodium" means the sodium salt of the disclosed compounds and includes the monosodium salt, the disodium salt and mixtures thereof. As used herein, the term "contacting" refers to any suitable method of bringing a compound or a pharmaceutical composition into contact with a cell in vivo, in vitro or ex vivo. For in vivo applications, any known method of administration is suitable as described herein. As used herein, the term "subject" refers to any recipient, for example a human or non- human mammal, of the compounds and / or pharmaceutical compositions described herein. Use of the above terms is meant to encompass substituted and unsubstituted moieties. Substitution may be by one or more groups such as alcohols, ethers, esters, amides, sulfones, sulfides, hydroxyl, nitro, cyano, carboxy, amines, heteroatoms, lower alkyl, lower alkoxy, lower alkoxycarbonyl, alkoxyalkoxy, acyloxy, halogens, trifluoromethoxy, trifluoromethyl, alkyl, aralkyl, alkenyl, alkynyl, aryl, cyano, carboxy, carboalkoxy, carboxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, alkylheterocyclyl, heterocyclylalkyl, oxo, arylsulfonyl and aralkylaminocarbonyl or any of the substituents of the preceding paragraphs or any of those substituents either attached directly or by suitable linkers. The linkers are typically short chains of 1-3 atoms containing any combination of --C--, --C(O)--, --NH--, --S--, --S(O)--, --O--, -- C(O)O-- or --S(O)O--. Rings may be substituted multiple times. In one embodiment of the invention there is provided a compound of formula I having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I) where R1 is [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] , or , <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics> and <semantics>R3<annotation encoding="application / x-tex">R^3< / annotation>< / semantics> are independently hydrogen or <semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics> alkyl; <semantics>R4<annotation encoding="application / x-tex">R^4< / annotation>< / semantics> is H or <semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics> alkyl; <semantics>R5<annotation encoding="application / x-tex">R^5< / annotation>< / semantics> is phenyl, aryl, heterocyclyl or aralkyl which is substituted with one or more of hydrogen, C1-4 alkyl, alkoxy, aryloxy, oxo, halogen, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; R6 is C1- 4 alkyl, halogen, phenyl, aryl or heterocyclyl which is substituted with one or more of hydrogen, C1-4 alkyl, alkoxy, aryl, aryloxy, halogen, oxo, acetyl, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; R7 is H or C1-4 alkyl; R8, R9 and R10 are independently hydrogen, halogen, C1-4 alkyl, C3-6 cycloalkyl, or hydroxyl; or a pharmaceutically acceptable salt or stereoisomers thereof. In this embodiment R2 and R3 are each hydrogen and R4 is hydrogen, methyl, ethyl or t-butyl. Also in this embodiment R7 is hydrogen, methyl or ethyl. Also in this embodiment R8 and R9 are independently hydrogen or methyl. Also in this embodiment R10 is hydroxyl. Also in this embodiment and all aspects thereof as described the pharmaceutically acceptable salt is a mono or a disodium salt and the stereoisomer is of the (S)-configuration. In one aspect of this embodiment, the provided compound of formula I is the compound of formula I A having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (IA) where, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as described supra or a pharmaceutically acceptable salt or stereoisomers thereof. In another aspect of this embodiment, the provided compound of formula I is the compound of formula I B having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I B) where, R2, R3, R4, R5, R6, R7, R9 and R10 are as described supra or a pharmaceutically acceptable salt or stereoisomers thereof. In yet another aspect of this embodiment, the provided compound of formula I is the compound of formula I C having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I C) where, R2, R3, R4, R5, R6, R7 and R10 are as described supra or a pharmaceutically acceptable salt or stereoisomers thereof. In yet another aspect of this embodiment, the provided compound of formula I is the compound of formula I is a compound of formula I D having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I D) where, R2, R3, R4, R5, R6, R7 and R10 are as described supra or a pharmaceutically acceptable salt or stereoisomers thereof. In yet another aspect of this embodiment, the provided compound of formula I is the compound of formula IE having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I E) where, R2, R3, R4, R5, R6, R7 and R10 are as described supra or a pharmaceutically acceptable salt or stereoisomers thereof. In yet another aspect of this embodiment, the provided compound of formula I is the compound of formula IF having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I F) where, R2, R3, R4, R5, R6, R9 and R10 are as described supra or a pharmaceutically acceptable salt or stereoisomers thereof. In another embodiment of the invention, there is provided pharmaceutical compositions comprising at least one compound as described supra and one or more pharmaceutically acceptable carriers. In yet another embodiment of the invention, there is provided a method for treating a pathophysiological condition mediated by <semantics>α4<annotation encoding="application / x-tex">\alpha 4< / annotation>< / semantics> integrins, e.g. <semantics>α4β1<annotation encoding="application / x-tex">\alpha 4\beta 1< / annotation>< / semantics>, <semantics>α4β7<annotation encoding="application / x-tex">\alpha 4\beta 7< / annotation>< / semantics> or mixed <semantics>α4β1<annotation encoding="application / x-tex">\alpha 4\beta 1< / annotation>< / semantics> and α4β7 integrins, in a subject in need of such treatment comprising administering to the subject a pharmacologically effective amount of the pharmaceutical composition as described supra. In this embodiment the pathophysiological condition is hematopoietic stem cell transplant therapy, sickle cell disease, dry eye, atherosclerosis, rheumatoid arthritis, asthma, allergy, multiple sclerosis, lupus, inflammatory bowel disease, graft rejection, contact hypersensitivity, stroke, pulmonary arterial hypertension, diabetes or cancer. In yet another embodiment of the invention, there is a method for inhibiting integrin binding in a cell associated with a pathophysiological condition, comprising: contacting the cell with one or more compounds as described supra. In this embodiment the integrin is <semantics>α4β1<annotation encoding="application / x-tex">\alpha_4\beta_1< / annotation>< / semantics> and / or <semantics>α4β7<annotation encoding="application / x-tex">\alpha_4\beta_7< / annotation>< / semantics> integrin. Also in this embodiment the pathophysiological condition is a cancer. In yet another embodiment of the invention, there is provided a compound of formula Il having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I) where R1 is [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] , or R2 and R3 are independently hydrogen; R4 is hydrogen; methyl, ethyl or t-butyl; R5 is phenyl, aryl, heterocyclyl or aralkyl which is substituted with one or more of hydrogen, C1-4 alkyl, alkoxy, aryloxy, oxo, halogen, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, - <semantics>OCF2CF2H<annotation encoding="application / x-tex">OCF_2CF_2H< / annotation>< / semantics>, <semantics>−O(C3−6<annotation encoding="application / x-tex">-O(C_{3-6}< / annotation>< / semantics> cycloalkyl), <semantics>−OCH2CF3<annotation encoding="application / x-tex">-OCH_2CF_3< / annotation>< / semantics>, thioalkoxy, dialkylamino, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl or haloalkyl; R6 is C1-4 alkyl, halogen, phenyl, aryl, heteroaryl which is substituted with one or more of hydrogen, C1-4 alkyl, alkoxy, aryl, aryloxy, halogen, oxo, acetyl, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; R7 is hydrogen, methyl or ethyl; R8 and R9 independently hydrogen or methyl; or a pharmaceutically acceptable salt or stereoisomers thereof. In yet another embodiment of the invention, there are provided the compounds: ethyl (S)-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido)propanoate 1-9; ethyl (S)-3-(biphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin- 3-yl)ureido)propanoate 1-10; ethyl 3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(2- oxo-3-phenylpyridin-1(2H)-yl)phenyl)propanoate 1-11; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoate 1-12; ethyl (S)-3-(2'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-13; [Image disponible dans le document PDF, Image available in the PDF document] ethyl (S)-3-(3',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-30; ethyl (S)-3-(2',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-31; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy biphenyl-3-yl)propanoate 1-32; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3' (trifluoromethoxy)biphenyl-3-yl)propanoate 1-33; ethyl (S)-3-(2',3'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-34; ethyl 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-oxo-1- phenyl-1,6-dihydropyridin-3-yl)propanoate 1-35; ethyl (S)-3-(2',6'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-36; ethyl (S)-3-(3'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-37; ethyl (S)-3-(4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-38; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethoxy)biphenyl-3-yl)propanoate 1-39; ethyl (S)-3-(2',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-40; ethyl (S)-3-(3',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-41; ethyl (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-42; ethyl 3-(4'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-43; ethyl (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-44; ethyl 3-(2'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido) propanoate 1-45; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethyl)biphenyl-3-yl)propanoate 1-46; ethyl (S)-3-(5,6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-47; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridin-3-yl)phenyl)propanoate 1-48; ethyl (S)-3-(2',5'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-49; ethyl 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyrimidin-5-yl) phenyl)propanoate 1-50; ethyl (S)-3-(2',6'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-51; ethyl 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2- dihydro pyridin -3-yl)ureido) propanoate 1-52; ethyl 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-53; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylfuran-2-yl)propanoate 1-54; ethyl (S)-3-(3-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2- oxo-1,2-dihydropyridin-3-yl)ureido)-propanoate 1-55; ethyl 3-(3'-chloro-4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido) propanoate 1-56; ethyl 3-(2',3'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-57; ethyl 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-58; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-59; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-60; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-2'-methylbiphenyl-3-yl)propanoate 1-61; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5'- methoxy-2'-methylbiphenyl-3-yl)propanoate 1-62; ethyl 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(2,2,2- trifluoro ethoxy)biphenyl-3-yl)propanoate 1-63; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] ethyl (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-132; ethyl (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-133; ethyl (S)-3-(5-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-134; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- methoxy phenyl)thiophen-2-yl)propanoate 1-135; ethyl (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-136; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-137; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2′,4′<annotation encoding="application / x-tex">(2',4'< / annotation>< / semantics>-difluoro-5-methoxybiphenyl-3-yl)-3-<semantics>(3−(4−hydroxy−1−methyl−2−oxo<annotation encoding="application / x-tex">(3-(4-hydroxy-1-methyl-2-oxo< / annotation>< / semantics> 1,2-dihydro pyridin-3-yl)ureido)propanoate 1-138; ethyl (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-139; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-140; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-methylbiphenyl-3-yl)propanoate 1-141; ethyl (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro pyridin- 3-yl)ureido)propanoate 1-142; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- phenylpyridin-2-yl)propanoate 1-143; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methyl- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-144; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethyl biphenyl-3-yl)propanoate 1-145; ethyl (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-146; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2′,4′<annotation encoding="application / x-tex">(2',4'< / annotation>< / semantics>-difluoro-5-methylbiphenyl-3-yl)-3-<semantics>(3−(4−hydroxy−1,6−dimethyl−2−oxo−<annotation encoding="application / x-tex">(3-(4-hydroxy-1,6-dimethyl-2-oxo-< / annotation>< / semantics> 1,2-dihydropyridin-3-yl)ureido)propanoate 1-147; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methyl- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-148; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-149; ethyl (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-150; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate 1-151; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate 1-152; ethyl (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-153; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-5-methylbiphenyl-3-yl)propanoate 1-154; ethyl <semantics>(S)−3−(2′,6′−dimethylbiphenyl−3−yl)−3−(3−(7−hydroxy−5−oxo−1,2,3,5−tetrahydro<annotation encoding="application / x-tex">(S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydro< / annotation>< / semantics> indolizin-6-yl) ureido)propanoate 1-155; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-methyl- [2,3'-bithiophen]-5-yl)propanoate 1-156; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl-[2,3'-bithiophen]-5-yl)propanoate 1-157; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-5-methylbiphenyl-3-yl)propanoate 1-158; ethyl (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-159; ethyl (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-160; ethyl (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-161; ethyl (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-162; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluoro biphenyl-3-yl)propanoate 1-163; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluoro biphenyl-3-yl)propanoate 1-164; ethyl (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-165; ethyl (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-166; ethyl (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl- 2-oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-167; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-methoxy biphenyl-3-yl)propanoate 1-168; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethyl biphenyl-3-yl)propanoate 1-169; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoate 1-170; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-3-yl)propanoate 1-171; ethyl (S)-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-172; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- (trifluoromethoxy)phenyl)thiophen-2-yl)propanoate 1-173; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate 1-174; ethyl (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-175; ethyl (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-176; ethyl (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-177; ethyl (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl- 2-oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-178; ethyl (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-179; ethyl (S)-3-(5-(3,5-dimethylisoxazol-4-yl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-180; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3−(3,5−dimethylisoxazol−4−yl)phenyl)−3−<math>(3−(4−hydroxy−1,6−dimethyl−2−oxo−dimethyl−2−oxo−dimethyl−2−oxo−dimethyl−2−oxo−dimethyl−2−oxo−dimethyl−2−oxo−dimethyl−2−oxo−dimethyl−2−oxo−dimethyl−2−oxo−dimethyl−2−o<annotation encoding="application / x-tex">(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-dimethyl-2-oxo-dimethyl-2-oxo-dimethyl-2-oxo-dimethyl-2-oxo-dimethyl-2-oxo-dimethyl-2-oxo-dimethyl-2-oxo-dimethyl-2-oxo-dimethyl-2-o< / annotation>< / semantics> 1,2-dihydropyridin-3-yl)ureido)propanoate 1-181; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2<annotation encoding="application / x-tex">(2< / annotation>< / semantics>-fluorobiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydro pyridin-3-yl) ureido)propanoate 1-182; ethyl (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-183; ethyl (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-184; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylthiophen-2-yl)propanoate 1-185; ethyl (S)-3-(5-(2,5-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-186; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(trifluoro methoxy)biphenyl-3-yl)propanoate 1-187; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-4-yl)propanoate 1-188; ethyl (S)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl)ureido)-3-(5- methoxybiphenyl-3-yl)propanoate 1-189; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(trifluoro methyl)biphenyl-3-yl)propanoate 1-190; ethyl (S)-3-(5-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-191; ethyl (S)-3-(5-(3-fluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-192; tert-butyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-193; tert-butyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-194; tert-butyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-195; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'-methyl- 6-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-196; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(trifluoro methoxy)biphenyl-3-yl)propanoate 1-197; ethyl 3-(3'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-198; ethyl 3-(4'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-199; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenyl thiophen-2-yl)propanoate 1-200; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenyl thiophen-2-yl)propanoate 1-201; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5- tetrahydroindolizin-6-yl) ureido)propanoate 1-202; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiazol- 2-yl) phenyl)propanoate 1-203; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-204; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoate 1-205; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoate 1-206; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-207; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-208; ethyl (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-209; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-4-yl)propanoate 1-210; ethyl (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-211; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin- 2-yl) phenyl)propanoate 1-212; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridazin-3-yl)phenyl)propanoate 1-213; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylpyridin-3-yl)propanoate 1-214; (S)-ethyl 3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-215; tert-butyl (S)-3-(biphenyl-4-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoate 1-216; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6'- methoxy pyridin-2-yl)phenyl)propanoate 1-217; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxy biphenyl-3-yl)propanoate 1-218; ethyl (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-219; ethyl 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl) ureido)propanoate 1-220, ethyl 3-(3-bromophenyl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoate 1-221 ethyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-222, ethyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-223, (S)-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-224, (S)-3-(biphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-225; 3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(2-oxo-3- phenyl pyridin-1(2H)-yl)phenyl)propanoic acid 1-226; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoic acid 1-227; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2′<annotation encoding="application / x-tex">(2'< / annotation>< / semantics>-fluorobiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-228; (S)-3-(6-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-229; (S)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-3-yl)propanoic acid 1-230; (S)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl biphenyl-3-yl)propanoic acid 1-231; 3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-232; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-233; (S)-3-(2',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-234; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methylbiphenyl-3-yl)propanoic acid 1-235; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxybiphenyl-3-yl)propanoic acid 1-236; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methylbiphenyl-3-yl)propanoic acid 1-237; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methylbiphenyl-3-yl)propanoic acid 1-238; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin-3- yl) phenyl)propanoic acid 1-239; (S)-3-(3',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-240; (S)-3-(3',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-241; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxybiphenyl-3-yl)propanoic acid 1-242; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methoxybiphenyl-3-yl)propanoic acid 1-243; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoromethyl) biphenyl-3-yl)propanoic acid 1-244; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid 1-245; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-246; (S)-3-(3',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-247; (S)-3-(2',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-248; (S)-3-(2',3'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-249; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-oxo-1-phenyl- 1,6-dihydropyridin-3-yl)propanoic acid 1-250; (S)-3-(2',6'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-251; (S)-3-(3'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-252; (S)-3-(4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-253; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-254; (S)-3-(2',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-255; (S)-3-(3',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-256; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-257; 3-(4'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-258; 3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-259; 3-(2'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-260; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethyl) biphenyl-3-yl)propanoic acid 1-261; (S)-3-(5,6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-262; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridin-3-yl)phenyl)propanoic acid 1-263; (S)-3-(2',5'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-264; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyrimidin-5- yl)phenyl) propanoic acid 1-265; (S)-3-(2',6'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-266; 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-267; 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-268; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylfuran-2-yl) propanoic acid 1-269; (S)-3-(3-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-270; 3-(3'-chloro-4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-271; 3-(2',3'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-272; 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-273; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-274; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-275; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 2'-methylbiphenyl-3-yl)propanoic acid 1-276; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5'-methoxy- 2'-methylbiphenyl-3-yl)propanoic acid 1-277; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(2,2,2- trifluoroethoxy) biphenyl-3-yl)propanoic acid 1-278; (S)-3-(2'-ethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-279; (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-280; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2′,4′<annotation encoding="application / x-tex">(2',4'< / annotation>< / semantics>-difluorobiphenyl-3-yl)-3-<semantics>(3−(4−hydroxy−2−oxo−1,2−dihydropyridin−3−<annotation encoding="application / x-tex">(3-(4-hydroxy-2-oxo-1,2-dihydropyridin-3-< / annotation>< / semantics> yl)ureido) propanoic acid 1-281; (S)-3-(3',4'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-282; (S)-3-(2',3'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-283; (S)-3-(4'-fluoro-3'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-284; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(1-phenyl- 1H-pyrrol-2-yl)propanoic acid 1-285; (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-286; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2- methylbiphenyl-3-yl)propanoic acid 1-287; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid 1-288; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-289; 3-(5'-chloro-2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-290; (S)-3-(2',3'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-291; (S)-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido)propanoic acid 1-292; (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-293; (S)-3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-294; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridin-3-yl)phenyl)propanoic acid 1-295; (S)-3-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-296; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-297; 3-(2',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-298; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-299; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-2,5,6,7-tetrahydro- 1H-cyclo penta[b]pyridin-3-yl)ureido)propanoic acid 1-300; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-301; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-4-methyl-5-oxo-4,5- dihydrothieno[3,2-b] pyridin-6-yl)ureido)propanoic acid 1-302; (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-303; (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-304; (S)-3-(3-(1H-indazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-305; (S)-3-(2',4'-difluoro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-306; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenylthiophen-2-yl) propanoic acid 1-307; (S)-3-(3-(1-ethyl-1H-indol-6-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl )ureido)propanoic acid 1-308; (S)-3-(3-(1H-pyrazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-309; (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-310; (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-311; 3-(2',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-312; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8- naphthyridin-3-yl)ureido)propanoic acid 1-313; (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-314; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-(3- methoxyphenyl) thiophen-2-yl)propanoic acid 1-315; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxybiphenyl-3-yl) propanoic acid 1-316; (S)-3-(4-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-317; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-318; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiophen-2- yl)phenyl) propanoic acid 1-319; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid 1-320; (S)-3-(3'-chloro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-321; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-322; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy-4'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-323; (S)-3-(2',6'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-324; (S)-3-(3-(5-chlorothiophen-2-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-325; (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-326; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(4- methylthiophen-3-yl)phenyl)propanoic acid 1-327; (S)-3-(2',4'-difluoro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-328; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-6- methyl biphenyl-3-yl)propanoic acid 1-329; (S)-3-(4-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin -3-yl)ureido)propanoic acid 1-330; (S)-3-(3-(1H-pyrrol-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-331; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trimethylbiphenyl-3-yl)propanoic acid 1-332; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trifluorobiphenyl-3-yl)propanoic acid 1-333; (S)-3-(6-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-334; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(1-methyl-1H- pyrazol-4-yl)phenyl)propanoic acid 1-335; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(5-hydroxy-2-methyl-3-oxo-2,3- dihydropyridazin-4-yl) ureido)propanoic acid 1-336; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-337; (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-338; (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-339; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid 1-340; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoic acid 1-341; (S)-3-(3'-chloro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-342; (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-343; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-344; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxybiphenyl-3-yl) propanoic acid 1-345; (S)-3-(3-(furan-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-346; (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-347; (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-348; (S)-3-(5-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-349; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- methoxyphenyl) thiophen-2-yl)propanoic acid 1-350; (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-351; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-352; (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-353; (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-354; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoic acid 1-355; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 6-methylbiphenyl-3-yl)propanoic acid 1-356; (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl) ureido)propanoic acid 1-357; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- phenylpyridin-2-yl) propanoic acid 1-358; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-359; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethylbiphenyl-3-yl)propanoic acid 1-360; (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-361; (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-362; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-363; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-364; (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-365; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-<semantics>(5<annotation encoding="application / x-tex">(5< / annotation>< / semantics>-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid 1-366; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid 1-367; (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-368; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-5- methyl biphenyl-3-yl)propanoic acid 1-369; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6- yl) ureido)propanoic acid 1-370; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-methyl-[2,3'- bithiophen]-5-yl)propanoic acid 1-371; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-methyl- [2,3'-bithiophen]-5-yl)propanoic acid 1-372; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 5-methyl biphenyl-3-yl)propanoic acid 1-373; (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-374; (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-375; (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-376; (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-377; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluorobiphenyl-3-yl)propanoic acid 1-378; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluorobiphenyl-3-yl)propanoic acid 1-379; (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-380; (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-381; (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoic acid 1-382; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>- methoxybiphenyl-3-yl)propanoic acid 1-383; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethylbiphenyl-3-yl)propanoic acid 1-384; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoic acid 1-385; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoic acid 1-386; (S)-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-387; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3-(trifluoro methoxy)phenyl)thiophen-2-yl)propanoic acid 1-388; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid 1-389; (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-390; (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-391; (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-392; (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoic acid 1-393; (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-394; (S)-3-(5-(3,5-dimethylisoxazol-4-yl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-395; (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-396; (S)-3-(2-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-397; (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-398; (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-399; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-<semantics>(5<annotation encoding="application / x-tex">(5< / annotation>< / semantics>- phenylthiophen-2-yl) propanoic acid 1-400; (S)-3-(5-(2,5-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-401; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- (trifluoromethoxy)biphenyl-3-yl)propanoic acid 1-402; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-4-yl)propanoic acid 1-403; (S)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl)ureido)-3-(5- methoxybiphenyl-3-yl)propanoic acid 1-404; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- (trifluoromethyl) biphenyl-3-yl)propanoic acid 1-405; (S)-3-(5-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-406; (S)-3-(5-(3-fluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-407; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-408; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-409; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-410; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'-methyl-6- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-411; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-412; 3-(3'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl) ureido)propanoic acid 1-413; 3-(4'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl) ureido)propanoic acid 1-414; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenylthiophen-2-yl)propanoic acid 1-415; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylthiophen-2-yl)propanoic acid 1-416; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6- yl) ureido)propanoic acid 1-417; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido) phenyl)propanoic acid 1-418; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-419; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoic acid 1-420; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluorobiphenyl-3-yl)propanoic acid 1-421; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-6- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-422; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 6-(trifluoromethoxy)biphenyl-3-yl)propanoic acid 1-423; (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-424; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-4-yl)propanoic acid 1-425; (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-426; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin-2- yl)phenyl) propanoic acid 1-427; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridazin-3-yl)phenyl)propanoic acid 1-428; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylpyridin-3-yl) propanoic acid 1-429; (S)-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(biphenyl-4-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido) propanoic acid 1-430; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6'- methoxypyridin-2-yl)phenyl)propanoic acid 1-431; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxybiphenyl-3-yl) propanoic acid 1-432; (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-433; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyrazin-2- yl)phenyl) propanoic acid 1-434, 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido) propanoic acid 1-435, 3-(3-bromophenyl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-436, [Image disponible dans le document PDF, Image available in the PDF document] sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3',5'- dimethyl biphenyl-3-yl)propanoate 1-454; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxy biphenyl-3-yl)propanoate 1-455; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methoxy biphenyl-3-yl)propanoate 1-456; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoro methyl)biphenyl-3-yl)propanoate 1-457; sodium (S)-3-(3',4'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate 1-458; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5'- dimethyl biphenyl-3-yl)propanoate 1-459; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy biphenyl-3-yl)propanoate 1-460; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoro methoxy)biphenyl-3-yl)propanoate 1-461; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',3'- dimethyl biphenyl-3-yl)propanoate 1-462; sodium 3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-oxo-1- phenyl-1,6-dihydropyridin-3-yl)propanoate 1-463; sodium (S)-3-(2',6'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate 1-464; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- fluoro biphenyl-3-yl)propanoate 1-465; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- fluoro biphenyl-3-yl)propanoate 1-466; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoro methoxy)biphenyl-3-yl)propanoate 1-467; sodium (S)-3-(2',4'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-468; sodium (S)-3-(3',4'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-469; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6'- dimethyl biphenyl-3-yl)propanoate 1-470; sodium 3-(4'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-471; sodium 3-(3'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-472; sodium 3-(2'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-473; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoro methyl)biphenyl-3-yl)propanoate 1-474; sodium (S)-3-(5,6-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-475; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridin-3-yl)phenyl)propanoate 1-476; sodium (S)-3-(2',5'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-477; sodium 3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyrimidin-5-yl) phenyl)propanoate 1-478; sodium (S)-3-(2',6'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-479; sodium 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1-ethyl-5-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-480; sodium 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-481; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylfuran-2-yl)propanoate 1-482; sodium (S)-3-(3-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-3-(3-(1,5-dimethyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-483; sodium 3-(3'-chloro-4'-fluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-484; sodium 3-(2',3'-dichlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-485; sodium 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-486; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-487; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] sodium (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-556; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(6-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-557; sodium (S)-3-(5-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-558; sodium (S)-3-(3-(furan-3-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-559; sodium (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-560; sodium (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-561; sodium (S)-3-(5-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-562; sodium (S)-3-(5-(3-methoxyphenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-563; sodium (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-564; sodium (S)-3-(5-methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-565; sodium (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo- 1,2-dihydro pyridin-3-yl)ureido)propanoate 1-566; sodium (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-567; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-568; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-methylbiphenyl-3-yl)propanoate 1-569; sodium (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-570; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- phenylpyridin-2-yl)propanoate 1-571; sodium (S)-3-(5-methyl-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-572; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethyl biphenyl-3-yl)propanoate 1-573; sodium (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-574; sodium (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-575; sodium (S)-3-(6-methyl-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-576; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-577; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- fluoro-2',6'-dimethylbiphenyl-3-yl)propanoate 1-578; sodium (S)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-579; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate 1-580; sodium (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-581; sodium (S)-3-(3'-methoxy-5-methylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-582; sodium (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(7-oxido-5-oxo-1,2,3,5-tetrahydro indolizin-6-yl) ureido)propanoate 1-583; sodium (S)-3-(4'-methyl-2,3'-bithiophen-5-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate 1-584; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl-2,3'-bithiophen-5-yl)propanoate 1-585; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-5-methylbiphenyl-3-yl)propanoate 1-586; sodium (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-587; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(2,6- dimethyl phenyl)thiophen-2-yl)propanoate 1-588; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- fluoro-2',6'-dimethylbiphenyl-3-yl)propanoate 1-589; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'-methyl- 6-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-624; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(trifluoro methoxy)biphenyl-3-yl)propanoate 1-625; sodium 3-(3'-acetylbiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydro pyridin-3-yl) ureido)propanoate 1-626; sodium 3-(4'-acetylbiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydro pyridin-3-yl) ureido)propanoate 1-627; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenyl thiophen-2-yl)propanoate 1-627; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenyl thiophen-2-yl)propanoate 1-628; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-oxido-5-oxo-1,2,3,5- tetrahydroindolizin-6-yl) ureido)propanoate 1-629; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiazol- 2-yl) phenyl)propanoate 1-630; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-631; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoate 1-632; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoate 1-633; sodium (S)-3-(3'-methoxy-6-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-634; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-635; sodium (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-636; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-4-yl)propanoate 1-637; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6'- dimethyl biphenyl-4-yl)propanoate 1-638; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin- 2-yl) phenyl)propanoate 1-639; sodium (S)-3-(3-(6-methoxypyridazin-3-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-640; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylpyridin-3-yl)propanoate 1-641; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- fluoro-2',6'-dimethylbiphenyl-3-yl)propanoate 1-642; sodium <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(biphenyl-4-yl)-3-<semantics>(3−(1,5−dimethyl−4−oxido−2−oxo−1,2−dihydropyridin−3−yl)<annotation encoding="application / x-tex">(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)< / annotation>< / semantics> ureido)propanoate 1-643; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6'- methoxy pyridin-2-yl)phenyl)propanoate 1-644; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxy biphenyl-3-yl)propanoate 1-645; sodium (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-646. sodium (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyrazin-2-yl)phenyl) propanoate 1-647, sodium 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydro pyridin-3- yl) ureido) propanoate 1-648, or sodium 3-(3-bromophenyl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido) propanoate 1-649. Provided herein are compounds and pharmaceutical compositions thereof that are derivatives of propanoic acid. Particularly, these compounds may comprise derivatives of biphenyl and biaryl propanoates such as, but not limited to, those compounds described in the Examples. These compounds encompass their pharmaceutically acceptable salts and / or their stereoisomers. As is known in the art, pharmaceutical compositions may comprise known carriers, excipients, diluents, etc, for example, saline, a buffer, an oil, or a powder. The pharmaceutical compositions may delivered in a vehicle such as, but not limited to, a spray, a liposome, a nanoparticle, a microparticle, a microcapsule, a nanosuspension, a microsuspension, or a hydrogel. The compounds and pharmaceutical compositions disclosed herein are useful as therapeutics and prophylactics against pathophysiological conditions in a subject in need of such treatment. The compounds and pharmaceutical composition may be administered one or more times to achieve a therapeutic effect. The compounds and pharmaceutical composition may be administered with other therapeutics for a particlular pathophysiological condition. As is known in the art, the skilled person is well-able to determine dose, dosage regimens and routes of administration depending on the condition to be treated and the subject requiring treatment. For example, treatment may be associated with inhibiting the binding of α4-integrin such as <semantics>α4β1<annotation encoding="application / x-tex">\alpha_4 \beta_1< / annotation>< / semantics> or <semantics>α4β7<annotation encoding="application / x-tex">\alpha_4 \beta_7< / annotation>< / semantics>. Representative examples of a pathophysiological condition that might be treated by the inhibition of <semantics>α4β1<annotation encoding="application / x-tex">\alpha_4\beta_1< / annotation>< / semantics> and / or <semantics>α4β7<annotation encoding="application / x-tex">\alpha_4\beta_7< / annotation>< / semantics> binding include, but are not limited to, hematopoietic stem cell transplant therapy, sickle cell disease, dry eye, atherosclerosis, rheumatoid arthritis, asthma, allergy, multiple sclerosis, lupus, inflammatory bowel disease, graft rejection, contact hypersensitivity, stroke, pulmonary arterial hypertension and diabetes or cancer. In addition to being found on some white blood cells, <semantics>α4β1<annotation encoding="application / x-tex">\alpha_4\beta_1< / annotation>< / semantics> is also found on various cancer cells, including leukemia, melanoma, lymphoma and sarcoma cells. It has been suggested that cell adhesion involving α4β1may be involved in the metastasis of certain cancers. Inhibitors of <semantics>α4β1<annotation encoding="application / x-tex">\alpha_4\beta_1< / annotation>< / semantics> binding may, therefore, also be useful in the treatment of some forms of cancer. The following examples are given for the purpose of illustrating various embodiments of the invention and are not meant to limit the present invention in any fashion. EXAMPLE 1 Synthesis of sodium (S)-3-(biphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydro pyridin-3-yl)ureido)propanoate (1-11) [Image disponible dans le document PDF, Image available in the PDF document] 1 Step One: To a suspension of sodium hydride (6.4 g of 60% dispersion in mineral oil, 160 mmol) in THF (400 mL) under a dry nitrogen atmosphere, TMEDA (23.4 mL, 155 mmol) and methyl propionylacetate (18.1 mL, 144 mmol) were added and the mixture was cooled to -45 °C. A solution of n-butyllithium (90 mL, 1.6M in hexanes, 274 mmol) was added dropwise and the resulting mixture was stirred at -45°C for 1 hour. Methyl formate (6.0 mL, 97 mmol) was then added rapidly and the mixture was allowed to stir for 30 minutes before quenching with HCl (6 N, 250 mL). The reaction was diluted with diethyl ether (150 mL) and the organic layer was washed twice more with water. The aqueous layers were combined and sodium chloride was added until saturated. This mixture was extracted with ethyl acetate (3 times). The original ether layer was washed with saturated sodium bicarbonate solution and water. The combined aqueous washes were acidified with excess HCl (2 N), saturated with sodium chloride and extracted with ethyl acetate (3 times). All of the ethyl acetate extracts were combined and dried over MgSO4. The resulting mixture was vacuum filtered through coarse silica gel and the filtrate was concentrated under reduced pressure to give methyl 5-hydroxy- 4-methyl-3-oxopent-4-enoate (1-1, 13.49 g) as a light yellow oil. This material was used without further purification. Step Two: To a solution of 1-1 (13.49 g, 85.3 mmol) in anhydrous methanol (250 mL) at room temperature, a solution of methylamine anhydrous methanol (2.0 M, 46.9 mL, 93.8 mmol) was added slowly. The solution was heated at 55° C two hours then refluxed overnight. The reaction mixture was cooled to room temperature and concentrated to dryness. The residue was brought up in dichloromethane and filtered. The solid was collected and dried under vacuum to give 4-hydroxy-1,5-dimethylpyridin-2(1H)-one (1-2, 4.056 g) as a light yellow solid. The filtrate was concentrated, taken up in acetone and filtered to yield and additional portion (1.636 g). This procedure was also used to prepare 1-ethyl-4-hydroxy-5-methylpyridin-2(1H)- one. Step Three: To a suspension of 1-2 (1.636 g, 11.8 mmol) in glacial acetic acid (40 mL) at room temperature, NaNO2 (41 mg, 0.59 mmol), water (3.36 mL) and HNO3 (70%, 2.27 mL, 35.3 mmol) were added sequentially. The resulting bright yellow solution was stirred at room temperature overnight, was diluted with water, and extracted with ethyl acetate three times. The organic layers were combined and washed with brine, dried over MgSO4 and filtered. This reaction was repeated on the remainder of the material from the previous step (4.047 g 1-2, 97 mL acetic acid; 100 mg NaNO2, 8.3 mL water and 5.6 mL nitric acid). The filtrates from the two reactions were combined and concentrated under reduced pressure to give 4-hydroxy- 1,5-dimethyl-3-nitropyridin-2(1H)-one (1-3, 6.47 g) as an yellow-orange solid. This procedure was also used to prepare 1-ethyl-4-hydroxy-5-methyl-3-nitropyridin-2(1H)-one; 4-hydroxy-1-methyl-3-nitro-6,7-dihydro-1H-cyclopenta[b]pyridin-2(5H)-one; 7-hydroxy-4-methyl-6-nitrothieno[3,2-b]pyridin-5(4H)-one; 7-hydroxy-6-nitro-2,3-dihydroindolizin-5(1H)-one; 4-hydroxy-1-methyl-3-nitro-1,8-naphthyridin-2(1H)-one; In the preparation of 5-hydroxy-2-methyl-4-nitropyridazin-3(2H)-one, this reaction was started at 0 °C and was allowed to warm to room temperature. Step Four: To a solution of 1-3 (6.45 g, 35.0 mmol) in DMF (117 mL) at room temperature under a dry nitrogen atmosphere, Zn powder (10.3 g, 158 mmol) and triethylamine hydrochloride (26.5 g, 193 mmol) were added. The resulting mixture was heated to 70 °C for 1 hour, and was cooled to room temperature. To the resulting mixture, CDI (11.36) g, 70.1 mmol) was added as a solid. Upon addition, gas evolution occurred. The mixture was then heated to 85 °C for 2 hours, cooled to room temperature, and filtered through a Buchner funnel into HCl (2 N). The suspension was stirred for 15 minutes, and filtered. The solid was resuspended in HCl (1 N), stirred for 15 minutes, and was filtered again, washing with water. The solid was dried under vacuum to give 5,7-dimethyloxazolo[4,5-c]pyridine-2,4(3H,5H)- dione (1-4, 3.981 g) as an off-white solid. This procedure was also used to prepare 5-ethyl-7-methyloxazolo[4,5-c]pyridine- 2,4(3H,5H)-dione, and 7,8-dihydrooxazolo[4,5-f]indolizine-2,4(3H,6H)-dione. This procedure was modified by using hydrogen chloride in dioxane (4.0 M, 5.5 equivalents) in place of triethylamine hydrochloride at 15 °C, warming to room temperature after adding CDI, to prepare 5-methyl-5,6,7,8-tetrahydro-2H-cyclopenta[b]oxazolo[5,4-d]pyridine-2,4(3H)-dione, 5-methyloxazolo[5,4-d]thieno[3,2-b]pyridine-2,4(3H,5H)-dione; 5-methyloxazolo[4,5-c][1,8]naphthyridine-2,4(3H,5H)-dione; and 5-methyloxazolo[4,5-d]pyridazine-2,4(3H,5H)-dione. Step Five: To a solution of 3-bromocinnamic acid (29.0 g, 127.7 mmol) in ethanol (450 mL), catalytic concentrated sulfuric (about 10 drops) was added. The reaction was heated to reflux overnight, concentrated under reduced pressure (to approximately 0.1 L), diluted with hot ethyl acetate, and washed with water (3 times) and saturated brine. The organic layer was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give (E)- ethyl 3-(3-bromophenyl)acrylate (1-5, 32.5 g). This procedure was also used to prepare ethyl (<semantics>E<annotation encoding="application / x-tex">E< / annotation>< / semantics>)-3-(3-bromo-4-fluorophenyl)acrylate and ethyl (<semantics>E<annotation encoding="application / x-tex">E< / annotation>< / semantics>)-3-(3-nitrophenyl)acrylate. Step Six: To a solution of <semantics>(R)<annotation encoding="application / x-tex">(R)< / annotation>< / semantics>-(+)-N-benzyl-<semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>-methylbenzylamine (20.3 g, 96 mmol) in tetrahydrofuran (150 mL) cooled to -78 °C under a nitrogen atmosphere, s-butyllithium (1.3 M in cyclohexane, 77 mL, 100 mmol) was added dropwise over 30 minutes. The mixture was stirred for 30 minutes, and a solution of 1-5 (20.4 g, 80 mmol) in tetrahydrofuran (100 mL) was added dropwise over 30 minutes. The resulting solution was stirred at -78°C for 3 hours, ethanol (8 mL) was added and the mixture was poured onto saturated aqueous ammonium chloride. The resulting mixture was extracted with ethyl acetate (3 times), and the organic layers were combined, washed with brine, dried over magnesium sulfate (anhydrous), filtered and concentrated under reduced pressure. The residue was purified by chromatography on silica gel, eluting with hexanes increasing to hexanes:acetate (9:1) to give ethyl (S)-3- <semantics>(benzyl((R)−1−phenylethyl)amino)−3−(3−bromophenyl)propanoate;(1−6,27.19g).<annotation encoding="application / x-tex">(benzyl((R)-1-phenylethyl) amino)-3-(3-bromophenyl)propanoate; (1-6, 27.19 g).< / annotation>< / semantics> This procedure was also accomplished using n-butyllithium in hexanes instead of s- butyllithium in cyclohexane without affecting the outcome. This procedure was also used to prepare ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(3-bromo-4-fluorophenyl)propanoate; ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(3-bromo-4-methylphenyl)propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl((<semantics>R<annotation encoding="application / x-tex">R< / annotation>< / semantics>)-1-phenylethyl)amino)-3-(3-bromo-4- methoxyphenyl)propanoate; tert-butyl (S)-3-(benzyl((<semantics>R<annotation encoding="application / x-tex">R< / annotation>< / semantics>)-1-phenylethyl)amino)-3-(4-bromophenyl)propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl(<semantics>(R)<annotation encoding="application / x-tex">(R)< / annotation>< / semantics>-1-phenylethyl)amino)-3-(5,6-dimethoxybiphenyl-3- yl)propanoate; ethyl (S)-3-(benzyl((<semantics>R<annotation encoding="application / x-tex">R< / annotation>< / semantics>)-1-phenylethyl)amino)-3-(3-nitrophenyl)propanoate (7-1); ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(benzyl((R)−1−phenylethyl)amino)−3−<math>(5−bromo−2−fluorophenyl)propanoate;<annotation encoding="application / x-tex">(benzyl((R)-1-phenylethyl)amino)-3-(5-bromo-2-fluorophenyl)propanoate;< / annotation>< / semantics> ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(benzyl((R)−1−phenylethyl)amino)−3−<math>(2−methylbiphenyl−3−yl)propanoate;<annotation encoding="application / x-tex">(benzyl((R)-1-phenylethyl)amino)-3-(2-methylbiphenyl-3-yl)propanoate;< / annotation>< / semantics> ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(benzyl((R)−1−phenylethyl)amino)−3−<math>(3−iodophenyl)propanoate;<annotation encoding="application / x-tex">(benzyl((R)-1-phenylethyl)amino)-3-(3-iodophenyl)propanoate;< / annotation>< / semantics> ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl((<semantics>R<annotation encoding="application / x-tex">R< / annotation>< / semantics>)-1-phenylethyl)amino)-3-(3-(1-ethyl-1H-indol-6- yl)phenyl)propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl(<semantics>(R)<annotation encoding="application / x-tex">(R)< / annotation>< / semantics>-1-phenylethyl)amino)-3-(6-methoxy-2',6'-dimethylbiphenyl-3- yl) propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl(<semantics>(R)<annotation encoding="application / x-tex">(R)< / annotation>< / semantics>-1-phenylethyl)amino)-3-(3-bromo-5- methoxyphenyl)propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(benzyl((R)−1−phenylethyl)amino)−3−<math>(3−bromo−5−methylphenyl)propanoate;<annotation encoding="application / x-tex">(benzyl((R)-1-phenylethyl)amino)-3-(3-bromo-5-methylphenyl)propanoate;< / annotation>< / semantics> ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(benzyl((R)−1−phenylethyl)amino)−3−<math>(3−bromo−5−fluorophenyl)propanoate;<annotation encoding="application / x-tex">(benzyl((R)-1-phenylethyl)amino)-3-(3-bromo-5-fluorophenyl)propanoate;< / annotation>< / semantics> ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl(<semantics>(R)<annotation encoding="application / x-tex">(R)< / annotation>< / semantics>-1-phenylethyl)amino)-3-(2',4',5-trifluorobiphenyl-3- yl)propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl((<semantics>R<annotation encoding="application / x-tex">R< / annotation>< / semantics>)-1-phenylethyl)amino)-3-(5-bromo-2- methoxyphenyl)propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl((<semantics>R<annotation encoding="application / x-tex">R< / annotation>< / semantics>)-1-phenylethyl)amino)-3-(3-iodo-4- (trifluoromethoxy)phenyl)propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl(<semantics>(R)<annotation encoding="application / x-tex">(R)< / annotation>< / semantics>-1-phenylethyl)amino)-3-(5-fluoro-3'-methoxybiphenyl-3-yl) propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl(<semantics>(R)<annotation encoding="application / x-tex">(R)< / annotation>< / semantics>-1-phenylethyl)amino)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl- 3-yl) propanoate; ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(2-fluoro-3-iodophenyl)propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl<semantics>(R)<annotation encoding="application / x-tex">(R)< / annotation>< / semantics>-1-phenylethyl)amino)-3-(3-bromo-5-(trifluoromethoxy)phenyl) propanoate; and ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl((<semantics>R<annotation encoding="application / x-tex">R< / annotation>< / semantics>)-1-phenylethyl)amino)-3-(2'-methyl-6-(trifluoromethoxy)bi- phenyl-3-yl) propanoate (from ethyl (<semantics>E<annotation encoding="application / x-tex">E< / annotation>< / semantics>)-3-(2'-methyl-6-(trifluoromethoxy)biphenyl-3- yl)acrylate). Step Seven: To a mixture of 1-6 (6.96 g, 14.9 mmol) and phenylboronic acid (2.00 g, 16.4 mmol) in dimethoxyethane (50 mL) at room temperature under nitrogen, tribasic potassium phosphate (7.91 g, 37.3 mmol) and bis(triphenylphoshine)palladium(II) dichloride (523 mg, 0.75 mmol) were added. The mixture was deoxygenated (toggle between vacuum and nitrogen gas 5 times) and heated to 85 °C overnight. The mixture was cooled, diluted with ethyl acetate, and washed with water and brine. The organic layer was dried, filtered and concentrated. The residue was purified by column chromatography on silica gel, eluting with hexanes and ethyl acetate to give ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(biphenyl-3- yl)propanoate (1-7, 5.49 g). This procedure was also used to prepare ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(benzyl(<semantics>(R)<annotation encoding="application / x-tex">(R)< / annotation>< / semantics>-1-phenylethyl)amino)- 3-(2'-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(2'-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(4'-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(3'-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(4'-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(2'-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(3'-methoxybiphenyl-3-yl)propanoate; ethyl 3-(3'-chloro-4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate (from ethyl 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5- dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)propanoate); ethyl 3-(2',3'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(5-methoxybiphenyl-3-yl)propanoate; ethyl 3-(1-ethyl-1H-indol-6-yl)benzoate (28-1, from 6-bromo-1-ethyl-1H-indole and 3- ethoxycarbonylphenylboronic acid). This reaction could also be performed with the addition of 2-5 fold excess equivalents of triethylamine. This modification was used to prepare ethyl 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate (from ethyl 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5- dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)propanoate); and ethyl 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate. In another modification of this procedure, water was added as co-solvent. This modification was used to prepare 5-(2,4-difluorophenyl)thiophene-2-carbaldehyde (from 5- bromothiophene-2-carboxaldehyde) and 5-(3-methoxyphenyl)thiophene-2-carbaldehyde. This procedure was further modified by using sodium bicarbonate as the base instead of potassium phosphate with DME and water as solvents. This modification was used to [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] 5-(3-chlorophenyl)thiophene-2-carbaldehyde; 5-(3-fluorophenyl)thiophene-2-carbaldehyde; 5-(3,5-dimethylisoxazol-4-yl)thiophene-2-carbaldehyde (from 5-formyl-2- thiopheneboronic acid and 3,5-dimethyl-4-iodoisoxazole); ethyl 3-(6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)-3-(tritylamino)propanoate (from ethyl 3- (3-bromo-4-(2,2,2-trifluoroethoxy)phenyl)-3-(tritylamino)propanoate); ethyl 3-(4'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate (from ethyl 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate); ethyl 3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; ethyl 3-(2'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; ethyl 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyrimidin-5-yl) phenyl)propanoate; ethyl 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl 3-(2',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; and ethyl 3-(5'-chloro-2',4'-difluorobiphenyl-3-yl)-3- (tritylamino)propanoate (from 3-1). Potassium carbonate could also be used as base instead of tribasic potassium phosphate with DMF and water as solvents. This modification was used to prepare ethyl (S)- 3-(benzyl((R)-1-phenylethyl)amino)-3-(2'-fluoro-3'-methoxybiphenyl-3-yl)propanoate; and ethyl 3-(2',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate (from ethyl 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5- dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)propanoate). Finally, the procedure was accomplished using a heterogeneous mixture of toluene and water as co-solvents to prepare ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(2',4'- difluorobiphenyl-3-yl)propanoate; ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(2',5'- difluorobiphenyl-3-yl)propanoate; and ethyl (S)-3-(benzyl((R)-1-phenylethyl)amino)-3-(3- (pyridin-3-yl)phenyl)propanoate (from 1-6 and 3-pyridineboronic acid 1,3-propanediol ester). Step Eight: To a solution of 1-7 (5.49 g, 11.3 mmol) in ethanol (75 mL), glacial acetic acid (0.4 mL), palladium metal on carbon (Degussa type E101 NE / W, 50% H2O, 10% Pd dry weight basis, 1.8 g, 0.83 mmol Pd). The atmosphere was replaced with hydrogen (toggling between vacuum and hydrogen from a balloon several times) and the reaction was stirred overnight. The mixture was filtered through Celite® and the filtrate was concentrated under reduced pressure. The residue was brought up in ethyl acetate, washed with saturated aqueous sodium carbonate, and the organic layer was dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with 15% then 40% ethyl acetate in hexanes, followed by 10% methanol in chloroform to give ethyl (S)-3-amino-3-(biphenyl-3-yl)propanoate; (1-8, 1.89 g). This procedure was also used to prepare ethyl (S)-3-amino-3-(2'-methylbiphenyl-3- yl)propanoate; ethyl (S)-3-amino-3-(2'-fluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(6-fluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',4'-difluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',5'-difluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(6-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(6-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(4'-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3'-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3-(pyridin-3-yl)phenyl)propanoate; ethyl (S)-3-amino-3-(3',5'-difluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3',5'-dimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(4'-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2'-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(4'-(trifluoromethyl)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3'-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(4'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3',4'-difluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',6'-difluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3'-fluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(4'-fluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',4'-dimethoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3',4'-dimethoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',6'-dimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2'-(trifluoromethyl)biphenyl-3-yl)propanoate; tert-butyl (S)-3-amino-3-(biphenyl-4-yl)propanoate; ethyl (S)-3-amino-3-(5,6-dimethoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3-(6-methoxypyridin-3-yl)phenyl)propanoate; ethyl (S)-3-amino-3-(2',5'-dimethoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',6'-dimethoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3'-methoxy-2'-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(5'-methoxy-2'-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2'-ethylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(4-fluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3',4'-dimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',3'-difluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(4'-fluoro-3'-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',3'-dimethoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2'-fluoro-3'-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)propanoate; ethyl (S)-3-(3-(1H-indazol-1-yl)phenyl)-3-aminopropanoate; ethyl (S)-3-amino-3-(2',4'-difluoro-6-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3-(1-ethyl-1H-indol-6-yl)phenyl)propanoate; ethyl (S)-3-(3-(1H-pyrazol-1-yl)phenyl)-3-aminopropanoate; ethyl (S)-3-amino-3-(3',6-dimethoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(6-methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(6-trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(6-methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(6-methoxy-4'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-aminopropanoate; ethyl (S)-3-amino-3-(2',4'-difluoro-6-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3'-methoxy-6-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',6,6'-trimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',6,6'-trifluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(6-fluoro-3'-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(5-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3',5-dimethoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(5-methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(5-methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(6-methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3'-methoxy-5-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',4,4'-trifluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(4-fluoro-3'-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(3'-methoxy-6-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2'-methyl-6-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(5-fluoro-3'-methoxybiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2-fluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(6-fluoro-2'-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',6'-dimethylbiphenyl-4-yl)propanoate; ethyl (S)-3-amino-3-(2'-methylbiphenyl-4-yl)propanoate; and ethyl (S)-3-amino-3-(5-(trifluoromethoxy)biphenyl-3-yl)propanoate. This procedure was also performed at 50 °C to prepare ethyl (S)-3-amino-3-(2',4',5-trifluorobiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(4-methoxybiphenyl-3-yl)propanoate; and ethyl (S)-3-amino-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)propanoate. This procedure was also modified by pre-treating a solution of the starting material and acetic acid in ethanol with activated charcoal. The mixture was stirred for 30 min to 1 hour at 40-50°C then was cooled before adding the palladium catalyst, exchanging the atmosphere with hydrogen gas, and completing the procedure at room temperature as described above to prepare ethyl (S)-3-amino-3-(2',5'-dimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-amino-3-(2',3'-dimethylbiphenyl-3-yl)propanoate; and ethyl (S)-3-amino-3-(3'-(trifluoromethyl)biphenyl-3-yl)propanoate. The hydrogenation was also carried out at 50°C after pretreating with activated charcoal to prepare ethyl (S)-3-amino-3-(2',5,6'-trimethylbiphenyl-3-yl)propanoate; and ethyl (S)-3-amino-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)propanoate; and ethyl (S)-3- amino-3-(4-methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate. The original procedure could also be modified to isolate the product as an acetic acid salt by concentrating the filtrate of the crude reaction mixture after filtering through Celite®. This modification gave ethyl (S)-3-amino-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)propanoate acetic acid salt; and tert-butyl (S)-3-amino-3-(2',4'-difluorobiphenyl-4-yl)propanoate acetic acid salt. Step Nine: A suspension of 1-5 (121 mg, 0.67 mmol) and 1-8 (800 mg, 3.86 mmol) in DMF (1.3 mL) under a dry nitrogen atmosphere was heated to 70 °C overnight, cooled to room temperature and then diluted with water. The resulting mixture was extracted with dichloromethane three times and the combined organic layers were dried over MgSO4 and filtered. The filtrate was concentrated under reduced pressure and the resulting residue was purified by silica gel chromatography, eluting with a gradient of 5 to 75% ethyl acetate in hexanes to give ethyl (S)-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate (1-9, 120 mg). For this transformation and the modifications described below, the temperature was varied from 50 to 90°C without a significant difference in the outcome. The progress of the reaction was monitored by TLC to ensure completion and the time and temperature was adjusted as needed. This procedure was also used to prepare ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-(biphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(1<annotation encoding="application / x-tex">(1< / annotation>< / semantics>-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-10; ethyl 3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(2- oxo-3-phenylpyridin-1(2H)-yl)phenyl)propanoate 1-11; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoate 1-12; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2′<annotation encoding="application / x-tex">(2'< / annotation>< / semantics>-fluorobiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydro pyridin-3-yl) ureido)propanoate 1-13; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(6<annotation encoding="application / x-tex">(6< / annotation>< / semantics>-fluorobiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydro pyridin-3-yl) ureido)propanoate 1-14; ethyl (S)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl biphenyl-3-yl)propanoate 1-15; ethyl 3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydro pyridin-3-yl) ureido)propanoate 1-16; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate 1-17; ethyl (S)-3-(2',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate 1-18; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methyl biphenyl-3-yl)propanoate 1-19; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxy biphenyl-3-yl)propanoate 1-20; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl biphenyl-3-yl)propanoate 1-21; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methyl biphenyl-3-yl)propanoate 1-22; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyridin-3-yl) phenyl)propanoate 1-23; ethyl (S)-3-(3',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-24; ethyl (S)-3-(3',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydro pyridin-3-yl)ureido)propanoate 1-25; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxy biphenyl-3-yl)propanoate 1-26; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyrazin-2-yl) phenyl)propanoate 1-28, ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoro methoxy)biphenyl-3-yl)propanoate 1-29; ethyl (S)-3-(3',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-30; ethyl (S)-3-(2',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-31; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoro methoxy)biphenyl-3-yl)propanoate 1-33; ethyl (S)-3-(2',3'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-34; ethyl 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-oxo-1- phenyl-1,6-dihydropyridin-3-yl)propanoate 1-35; ethyl (S)-3-(2',6'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate 1-36; ethyl (S)-3-(3'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydropyridin-3-yl) ureido)propanoate 1-37; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(4′<annotation encoding="application / x-tex">(4'< / annotation>< / semantics>-fluorobiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydro pyridin-3-yl) ureido)propanoate 1-38; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoro methoxy)biphenyl-3-yl)propanoate 1-39; ethyl (S)-3-(2',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-40; ethyl (S)-3-(3',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-41; ethyl (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydro pyridin-3-yl)ureido)propanoate 1-42; ethyl 3-(4'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-43; ethyl (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-44; ethyl 3-(2'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-45; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoro methyl)biphenyl-3-yl)propanoate 1-46; ethyl (S)-3-(5,6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-47; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridin-3-yl)phenyl)propanoate 1-48; ethyl (S)-3-(2',5'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-49; ethyl 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyrimidin-5-yl) phenyl)propanoate 1-50; ethyl (S)-3-(2',6'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-51; ethyl 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido) propanoate 1-52; ethyl 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-53; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylfuran-2-yl)propanoate 1-54; ethyl (S)-3-(3-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-55; ethyl 3-(3'-chloro-4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-56; ethyl 3-(2',3'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-57; ethyl 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-58; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-59; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-60; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-2'-methylbiphenyl-3-yl)propanoate 1-61; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5'- methoxy-2'-methylbiphenyl-3-yl)propanoate 1-62; ethyl 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(2,2,2- trifluoro ethoxy)biphenyl-3-yl)propanoate 1-63; ethyl (S)-3-(2'-ethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-64; ethyl (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-65; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoate 1-66; ethyl (S)-3-(3',4'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydro pyridin-3-yl)ureido)propanoate 1-67; ethyl (S)-3-(2',3'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate 1-68; ethyl (S)-3-(4'-fluoro-3'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-69; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(1- phenyl-1H-pyrrol-2-yl)propanoate 1-70; ethyl (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-71; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2- methyl biphenyl-3-yl)propanoate 1-72; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy biphenyl-3-yl)propanoate 1-73; ethyl (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-74; ethyl 3-(5'-chloro-2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-75; ethyl (S)-3-(2',3'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-76; ethyl (S)-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoate 1-77; ethyl (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-78; ethyl (S)-3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-79; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridin-3-yl)phenyl)propanoate 1-80; ethyl (S)-3-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-81; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-(trifluoro methoxy)biphenyl-3-yl)propanoate 1-82; ethyl 3-(2',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-83; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'-(trifluoro methoxy)biphenyl-3-yl)propanoate 1-84; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-2,5,6,7- tetrahydro-1H-cyclopenta[b]pyridin-3-yl)ureido)propanoate 1-85; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-(trifluoro methoxy)biphenyl-3-yl)propanoate 1-86; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-4-methyl-5-oxo-4,5- dihydrothieno[3,2-b]pyridin-6-yl)ureido)propanoate 1-87; ethyl (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-88; ethyl (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-89; ethyl (S)-3-(2',4'-difluoro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-91; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenylthiophen-2-yl)propanoate 1-92; ethyl (S)-3-(3-(1-ethyl-1H-indol-6-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-93; ethyl (S)-3-(3-(1H-pyrazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-94; ethyl (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-95; ethyl (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-96; ethyl 3-(2',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-97; ethyl (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-99; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-(3- methoxy phenyl)thiophen-2-yl)propanoate 1-100; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy biphenyl-3-yl)propanoate 1-101; ethyl (S)-3-(4-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-102; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-2-oxo-1,2-dihydro pyridin-3-yl) ureido)propanoate 1-103; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (thiophen-2-yl) phenyl)propanoate 1-104; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate 1-105; ethyl (S)-3-(3'-chloro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-106; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-107; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxy-4'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-108; ethyl (S)-3-(2',6'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-109; ethyl (S)-3-(3-(5-chlorothiophen-2-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-110; ethyl (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-111; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(4- methyl thiophen-3-yl)phenyl)propanoate 1-112; ethyl (S)-3-(2',4'-difluoro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-113; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-methylbiphenyl-3-yl)propanoate 1-114; ethyl (S)-3-(4-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-115; ethyl (S)-3-(3-(1H-pyrrol-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro pyridin-3-yl)ureido)propanoate 1-116; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trimethyl biphenyl-3-yl)propanoate 1-117; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trifluoro biphenyl-3-yl)propanoate 1-118; ethyl (S)-3-(6-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-119; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(1- methyl-1H-pyrazol-4-yl)phenyl)propanoate 1-120; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(5-hydroxy-2-methyl-3-oxo-2,3- dihydropyridazin-4-yl)ureido)propanoate 1-121; ethyl (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-122; ethyl (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-123; ethyl (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-124; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy biphenyl-3-yl)propanoate 1-125; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-126; ethyl (S)-3-(3'-chloro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-127; ethyl (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-128; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-6-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-129; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy biphenyl-3-yl)propanoate 1-130; ethyl (S)-3-(3-(furan-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro pyridin- 3-yl) ureido)propanoate 1-131; ethyl <semantics>(S)−3−(3−(3,5−dimethylisoxazol−4−yl)phenyl)−3−(3−(4−hydroxy−1−methyl−2−oxo−1,2−<annotation encoding="application / x-tex">(S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-< / annotation>< / semantics> dihydro pyridin-3-yl)ureido)propanoate 1-132; ethyl (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-133; ethyl (S)-3-(5-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-134; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- methoxy phenyl)thiophen-2-yl)propanoate 1-135; ethyl (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-136; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-137; ethyl (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo- 1,2-dihydro pyridin-3-yl)ureido)propanoate 1-138; ethyl (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-139; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-140; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-methylbiphenyl-3-yl)propanoate 1-141; ethyl (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-142; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- phenylpyridin-2-yl)propanoate 1-143; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methyl- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-144; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methyl- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-148; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-149; ethyl (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-150; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate 1-151; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate 1-152; ethyl (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-153; ethyl <semantics>(S)−3−(2′,6′−dimethylbiphenyl−3−yl)−3−(3−(7−hydroxy−5−oxo−1,2,3,5−tetrahydroxy−5−oxo−1,2,3,5−tetrahydroxy−5−oxo−1,2,3,5−tetrahydroxy−5−oxo−1,2,3,5−tetrahydroxy−5−oxo−1,2,3,5−tetrahydroxy−5−oxo−1,2,3,5−tetrahydroxy−5−oxo−<annotation encoding="application / x-tex">(S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroxy-5-oxo-1,2,3,5-tetrahydroxy-5-oxo-1,2,3,5-tetrahydroxy-5-oxo-1,2,3,5-tetrahydroxy-5-oxo-1,2,3,5-tetrahydroxy-5-oxo-1,2,3,5-tetrahydroxy-5-oxo-< / annotation>< / semantics> indolizin-6-yl) ureido)propanoate 1-155; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-methyl- [2,3'-bithiophen]-5-yl)propanoate 1-156; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl-[2,3'-bithiophen]-5-yl)propanoate 1-157; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-5-methylbiphenyl-3-yl)propanoate 1-158; ethyl (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-159; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(5<annotation encoding="application / x-tex">(5< / annotation>< / semantics>-<semantics>(2,6<annotation encoding="application / x-tex">(2,6< / annotation>< / semantics>-dimethylphenyl)thiophen-2-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-160; ethyl (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-161; ethyl (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-162; ethyl (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-165; ethyl (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-166; ethyl (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl- 2-oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-167; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-methoxy biphenyl-3-yl)propanoate 1-168; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethyl biphenyl-3-yl)propanoate 1-169; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoate 1-170; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-3-yl)propanoate 1-171; ethyl (S)-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-172; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- (trifluoro methoxy)phenyl)thiophen-2-yl)propanoate 1-173; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate 1-174; ethyl (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-175; ethyl (S)-3-(5-(3,5-dimethylisoxazol-4-yl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-180; ethyl (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-181; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylthiophen-2-yl)propanoate 1-185; ethyl (S)-3-(5-(2,5-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-186; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(tri fluoro methoxy)biphenyl-3-yl)propanoate 1-187; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-4-yl)propanoate 1-188; ethyl (S)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl)ureido)-3-(5- methoxybiphenyl-3-yl)propanoate 1-189; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(tri fluoro methyl)biphenyl-3-yl)propanoate 1-190; ethyl (S)-3-(5-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-191; ethyl (S)-3-(5-(3-fluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-192; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'-methyl- 6-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-196; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenylthiophen-2-yl)propanoate 1-200; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenyl thiophen-2-yl)propanoate 1-201; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5- tetrahydroindolizin-6-yl) ureido)propanoate 1-202; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiazol- 2-yl) phenyl)propanoate 1-203; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoate 1-205; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoate 1-206; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-207; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-208; ethyl (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-209; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-4-yl)propanoate 1-210; ethyl (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-211; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin- 2-yl) phenyl)propanoate 1-212; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridazin-3-yl)phenyl)propanoate 1-213; tert-butyl (S)-3-(biphenyl-4-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoate 1-216; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6'- methoxy pyridin-2-yl)phenyl)propanoate 1-217; ethyl (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-219; ethyl 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoate 1-220, ethyl 3-(3-bromophenyl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoate 1-221 ethyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-222, ethyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-223, The procedure was also modified by adding a base. This modification was used in all instances when the amine starting material had been isolated as a hydrochloride or acetic acid salt, but was also sometimes used on freebased amines. Sodium bicarbonate was used in the preparation of: ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluoro biphenyl-3-yl)propanoate 1-163; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluoro biphenyl-3-yl)propanoate 1-164; ethyl (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-176; ethyl (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-177; ethyl (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl- 2-oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-178; ethyl (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-179; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2<annotation encoding="application / x-tex">(2< / annotation>< / semantics>-fluorobiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydro pyridin-3-yl) ureido)propanoate 1-182; ethyl (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-183; and ethyl (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-184;. ethyl 3-(3'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-198; and ethyl 3-(4'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-199. Diisopropylethylamine was used to prepare ethyl (S)-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-215; N-Methylmorpholine was used in the preparation of ethyl (S)-3-(3-(1H-indazol-1- yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-90; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro- 1,8-naphthyridin-3-yl)ureido)propanoate 1-98; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethyl biphenyl-3-yl)propanoate 1-145; ethyl (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-146; ethyl (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-147; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-5-methylbiphenyl-3-yl)propanoate 1-154; tert-butyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-193; tert-butyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-194; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-195; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-204 and ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylpyridin-3-yl)propanoate 1-214; and Finally, triethylamine was used to prepare ethyl (S)- 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'-methoxybiphenyl-3- yl)propanoate 1-27; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy biphenyl-3-yl)propanoate 1-32; tert-butyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-195; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(trifluoro methoxy)biphenyl-3-yl)propanoate 1-197; and ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxy biphenyl-3-yl)propanoate 1-218. Step Ten: To a solution of 1-9 (120 mg, 0.266 mmol) in THF (4 mL) at room temperature sodium hydroxide (2 N, 2 mL) and methanol (1 mL) were added. The mixture was stirred for 2 hours, and the organic solvents were removed on the rotary evaporator. The remaining aqueous solution was diluted with water, and acidified with HCl (2N) The resulting suspension was filtered, washing with water. The solid was dried under vacuum to give (S)-3- (biphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)propanoic acid (1-224, 96 mg). This procedure was also used to prepare (S)-3-(biphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-225; 3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(2-oxo-3- phenylpyridin-1(2H)-yl)phenyl)propanoic acid 1-226; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoic acid 1-227; (S)-3-(2'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-228; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(6<annotation encoding="application / x-tex">(6< / annotation>< / semantics>-fluorobiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-229; (S)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-3-yl)propanoic acid 1-230; (S)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl biphenyl-3-yl)propanoic acid 1-231; 3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-232; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-233; (S)-3-(2',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-234; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methylbiphenyl-3-yl)propanoic acid 1-235; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxybiphenyl-3-yl)propanoic acid 1-236; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methylbiphenyl-3-yl)propanoic acid 1-237; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methylbiphenyl-3-yl)propanoic acid 1-238; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin-3- yl) phenyl)propanoic acid 1-239; (S)-3-(3',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-240; (S)-3-(3',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-241; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxybiphenyl -3-yl)propanoic acid 1-242; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methoxybiphenyl -3-yl)propanoic acid 1-243; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoromethyl) biphenyl-3-yl)propanoic acid 1-244; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid 1-245; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-246; (S)-3-(3',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-247; (S)-3-(2',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-248; (S)-3-(2',3'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-249; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-oxo-1-phenyl- 1,6-dihydropyridin-3-yl)propanoic acid 1-250; (S)-3-(2',6'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-251; (S)-3-(3'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-252; (S)-3-(4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-253; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-254; (S)-3-(2',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-255; (S)-3-(3',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-256; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-257; 3-(4'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-258; 3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-259; 3-(2'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-260; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethyl) biphenyl-3-yl)propanoic acid 1-261; (S)-3-(5,6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-262; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridin-3-yl)phenyl)propanoic acid 1-263; (S)-3-(2',5'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-264; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyrimidin-5- yl)phenyl) propanoic acid 1-265; (S)-3-(2',6'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-266; 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-267; 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-268; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylfuran-2-yl) propanoic acid 1-269; (S)-3-(3-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-270; 3-(3'-chloro-4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-271; 3-(2',3'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-272; 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-273; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-274; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-275; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 2'-methylbiphenyl-3-yl)propanoic acid 1-276; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5'-methoxy- 2'-methylbiphenyl-3-yl)propanoic acid 1-277; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(2,2,2- trifluoroethoxy) biphenyl-3-yl)propanoic acid 1-278; (S)-3-(2'-ethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-279; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-fluorobiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-280; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2′,4′<annotation encoding="application / x-tex">(2',4'< / annotation>< / semantics>-difluorobiphenyl-3-yl)-3-<semantics>(3−(4−hydroxy−2−oxo−1,2−dihydropyridin−3−yl)<annotation encoding="application / x-tex">(3-(4-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)< / annotation>< / semantics> ureido)propanoic acid 1-281; (S)-3-(3',4'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-282; (S)-3-(2',3'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-283; (S)-3-(4'-fluoro-3'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-284; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(1-phenyl- 1H-pyrrol-2-yl)propanoic acid 1-285; (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-286; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2- methylbiphenyl-3-yl)propanoic acid 1-287; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid 1-288; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-289; 3-(5'-chloro-2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-290; (S)-3-(2',3'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-291; (S)-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido)propanoic acid 1-292; (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl) ureido)propanoic acid 1-293; (S)-3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-294; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridin-3-yl) phenyl)propanoic acid 1-295; (S)-3-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-296; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-297; 3-(2',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-298; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-299; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-2,5,6,7-tetrahydro- 1H-cyclopenta[b]pyridin-3-yl)ureido)propanoic acid 1-300; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-301; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-4-methyl-5-oxo-4,5- dihydrothieno[3,2-b]pyridin-6-yl)ureido)propanoic acid 1-302; (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-303; (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-304; (S)-3-(3-(1H-indazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-305; (S)-3-(2',4'-difluoro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-306; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenylthiophen-2-yl) propanoic acid 1-307; (S)-3-(3-(1-ethyl-1H-indol-6-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-308; (S)-3-(3-(1H-pyrazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-309; (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-310; (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-311; 3-(2',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-312; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8- naphthyridin -3-yl)ureido)propanoic acid 1-313; <semantics>(S)−3−(3′,6−dimethoxybiphenyl−3−yl)−3−(3−(4−hydroxy−1,5−dimethyl−2−oxo−1,2−dimethyl−2−oxo−1,2−dimethyl−2−oxo−1,2−dimethyl−2−oxo−1,2−dimethyl−2−oxo−1,2−dimethyl−2−oxo−1,2−dimethyl−2−oxo−1,2−dimethyl−2−oxo−1,2−dimethyl−2−o<annotation encoding="application / x-tex">(S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dimethyl-2-oxo-1,2-dimethyl-2-oxo-1,2-dimethyl-2-oxo-1,2-dimethyl-2-oxo-1,2-dimethyl-2-oxo-1,2-dimethyl-2-oxo-1,2-dimethyl-2-oxo-1,2-dimethyl-2-o< / annotation>< / semantics> dihydropyridin-3-yl)ureido)propanoic acid 1-314; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-(3- methoxyphenyl) thiophen-2-yl)propanoic acid 1-315; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxybiphenyl-3-yl) propanoic acid 1-316; (S)-3-(4-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-317; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridin-3- yl)ureido)propanoic acid 1-318; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiophen-2- yl) phenyl)propanoic acid 1-319; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid 1-320; (S)-3-(3'-chloro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-321; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-322; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy-4'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-323; (S)-3-(2',6'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-324; (S)-3-(3-(5-chlorothiophen-2-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-325; (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-326; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(4- methylthiophen-3-yl)phenyl)propanoic acid 1-327; (S)-3-(2',4'-difluoro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-328; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-6- methyl biphenyl-3-yl)propanoic acid 1-329; (S)-3-(4-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-330; (S)-3-(3-(1H-pyrrol-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-331; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trimethylbiphenyl-3-yl)propanoic acid 1-332; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trifluorobiphenyl-3-yl)propanoic acid 1-333; (S)-3-(6-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-334; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(1-methyl-1H- pyrazol-4-yl)phenyl)propanoic acid 1-335; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(5-hydroxy-2-methyl-3-oxo-2,3- dihydropyridazin-4-yl) ureido)propanoic acid 1-336; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-337; (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-338; (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-339; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid 1-340; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoic acid 1-341; (S)-3-(3'-chloro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-342; (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-343; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-344; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxybiphenyl-3-yl) propanoic acid 1-345; (S)-3-(3-(furan-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-346; (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-347; (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-348; (S)-3-(5-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-349; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- methoxyphenyl) thiophen-2-yl)propanoic acid 1-350; (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-351; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-352; (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-353; (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-354; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoic acid 1-355; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 6-methylbiphenyl-3-yl)propanoic acid 1-356; (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido)propanoic acid 1-357; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- phenylpyridin-2-yl)propanoic acid 1-358; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-<semantics>(5<annotation encoding="application / x-tex">(5< / annotation>< / semantics>-methyl-3'- (trifluoromethoxy)biphenyl-3-yl)propanoic acid 1-359; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethylbiphenyl-3-yl)propanoic acid 1-360; (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-361; (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-362; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-363; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-364; (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-365; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid 1-366; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid 1-367; (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-368; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-5- methyl biphenyl-3-yl)propanoic acid 1-369; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6- yl) ureido)propanoic acid 1-370; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-methyl-[2,3'- bithiophen]-5-yl)propanoic acid 1-371; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-methyl- [2,3'-bithiophen]-5-yl)propanoic acid 1-372; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 5-methyl biphenyl-3-yl)propanoic acid 1-373; (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-374; (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-375; (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-376; (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-377; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluorobiphenyl-3-yl)propanoic acid 1-378; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluoro biphenyl-3-yl)propanoic acid 1-379; (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-380; (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-381; (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydro pyridin-3-yl)ureido)propanoic acid 1-382; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- methoxybiphenyl-3-yl) propanoic acid 1-383; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethyl biphenyl-3-yl)propanoic acid 1-384; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl) propanoic acid 1-385; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoic acid 1-386; (S)-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-387; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- (trifluoromethoxy) phenyl)thiophen-2-yl)propanoic acid 1-388; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid 1-389; (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-390; (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-391; (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-392; (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoic acid 1-393; (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-394; (S)-3-(5-(3,5-dimethylisoxazol-4-yl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-395; (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid 1-396; (S)-3-(2-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid 1-397; (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-398; (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-399; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylthiophen-2-yl) propanoic acid 1-400; (S)-3-(5-(2,5-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-401; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-402; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-4-yl) propanoic acid 1-403; (S)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl)ureido)-3-(5- methoxybiphenyl-3-yl) propanoic acid 1-404; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- (trifluoromethyl) biphenyl-3-yl)propanoic acid 1-405; (S)-3-(5-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-406; (S)-3-(5-(3-fluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid 1-407; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-408; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-409; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-410; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'-methyl-6- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-411; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- (trifluoromethoxy) biphenyl-3-yl)propanoic acid 1-412; 3-(3'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-413; 3-(4'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-414; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenylthiophen-2-yl)propanoic acid 1-415; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-<semantics>(5<annotation encoding="application / x-tex">(5< / annotation>< / semantics>- phenylthiophen-2-yl)propanoic acid 1-416; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6- yl) ureido)propanoic acid 1-417; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiazol-2- yl)phenyl) propanoic acid 1-418; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-419; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoic acid 1-420; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluorobiphenyl-3-yl)propanoic acid 1-421; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-6- (trifluoro methoxy)biphenyl-3-yl)propanoic acid 1-422; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 6-(trifluoromethoxy)biphenyl-3-yl)propanoic acid 1-423; (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-424; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-4-yl)propanoic acid 1-425; (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid 1-426; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin-2- yl)phenyl) propanoic acid 1-427; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridazin-3-yl)phenyl)propanoic acid 1-428; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylpyridin-3-yl) propanoic acid 1-429; (S)-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(biphenyl-4-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido) propanoic acid 1-430; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6'- methoxypyridin-2-yl)phenyl)propanoic acid 1-431; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>- methoxybiphenyl-3-yl)propanoic acid 1-432; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(1H<annotation encoding="application / x-tex">(1H< / annotation>< / semantics>-imidazol-1-yl)phenyl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid 1-433; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyrazin-2- yl)phenyl) propanoic acid 1-434, 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido) propanoic acid 1-435, 3-(3-bromophenyl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid 1-436, The product was crystallized from ethyl acetate during the preparation of (S)-3-(5- fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido)propanoic acid. Step Eleven: To a solution of 1-224 (96 mg, 0.228 mmol) in inhibitor free tetrahydrofuran (2.5 mL), aqueous sodium hydroxide (0.1000 N, 4.57 mL, 0.457 mmol) was added. The mixture was heated briefly to 40 °C to give a homogeneous mixture, and the tetrahydrofuran was removed by rotary evaporation. The mixture was diluted with deionized water, then frozen in a dry ice / acetone bath and lyophilized to give sodium (S)-3-(biphenyl-3- yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl) ureido)propanoate; (1-437, 115 mg) as a fluffy white powder. (MS [M+H+]+: Calculated: 422.17; Measured: 422.09; IC50<20 nM). This method was also used to prepare: sodium (S)-3-(biphenyl-3-yl)-3-(3-(1-ethyl-5-methyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-438 (MS [M+H+]+: Calculated: 436.19; Measured: 436.05; α4β1 IC50 <semantics>=<200 nM:α4β7 IC50=nd;<annotation encoding="application / x-tex">= < 200 \text{ nM}: \alpha 4\beta 7 \text{ IC}_{50} = \text{nd};< / annotation>< / semantics> sodium 3-(3-(1-ethyl-5-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(2- oxo-3-phenylpyridin-1(2H)-yl)phenyl)propanoate 1-439 (MS [M+H+]+: Calculated: 529.21; Measured: 529.21); <semantics>α4β1 IC50=200 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = 200 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-3-yl)propanoate 1-440 (MS [M+H+]+: Calculated: 436.19 Measured: 436.11; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- fluoro biphenyl-3-yl)propanoate 1-441 (MS [M+H+]+: Calculated: 440.16; Measured: 440.04; <semantics>α4β1IC50=<20nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 20 \ \text{nM} : \alpha 4\beta 7 \ \text{IC}_{50} = \text{nd};< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- fluoro biphenyl-3-yl)propanoate 1-442 (MS [M+H+]+: Calculated: 440.16; Measured: 440.10; <semantics>α4β11C50=<20<annotation encoding="application / x-tex">\alpha 4\beta 11C_{50} = < 20< / annotation>< / semantics> nM: <semantics>α4β71C50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 1C_{50} = nd< / annotation>< / semantics>; sodium (S)-3-(3-(1-ethyl-5-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-3-yl)propanoate 1-443 (MS [M+H+]+: Calculated: 450.20; Measured: 450.14; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3-(1-ethyl-5-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl biphenyl-3-yl)propanoate 1-444 (MS [M+H+]+: Calculated: 450.20; Measured: 450.11; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium 3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-445 (MS [M+H+]+: Calculated: 411.17; Measured: 411.10; <semantics>α4β1IC50=<200nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 200 \ \text{nM}< / annotation>< / semantics>: <semantics>α4β7IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \ \text{IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-446 (MS [M+H+]+: Calculated: 458.15; Measured: 458.07; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(2',5'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-447 (MS [M+H+]+: Calculated: 458.15; Measured: 458.06; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methyl biphenyl-3-yl)propanoate 1-448 (MS [M+H+]+: Calculated: 436.19; Measured: 136.15; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxybiphenyl-3-yl)propanoate 1-449 (MS [M+H+]+: Calculated: 452.18; Measured: 452.11; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl biphenyl-3-yl)propanoate 1-450 (MS [M+H+]+: Calculated: 436.19; Measured: 436.07; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methyl biphenyl-3-yl)propanoate 1-451 (MS [M+H+]+: Calculated: 436.19; Measured: 435.96; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-p1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyridin-3-yl)phenyl)propanoate 1-452 (MS [M+H+]+: Calculated: 423.17; Measured: 423.15; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3',5'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate 1-453 (MS [M+H+]+: Calculated: 458.15; Measured: 458.06; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = nd; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3',5'- dimethyl biphenyl-3-yl)propanoate 1-454 (MS [M+H+]+: Calculated: 450.20; Measured: 450.08; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxy biphenyl-3-yl)propanoate 1-455; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoro methyl)biphenyl-3-yl)propanoate 1-457 (MS [M+H+]+: Calculated: 490.16; Measured: 490.10; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 200 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoro methoxy)biphenyl-3-yl)propanoate 1-457 (MS [M+H+]+: Calculated: 506.15; Measured: 506.14; <semantics>α4β1 IC50=<200 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 200 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3',4'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate 1-458 (MS [M+H+]+: Calculated: 458.15; Measured: 458.15; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5'- dimethyl biphenyl-3-yl)propanoate 1-459 (MS [M+H+]+: Calculated: 450.20; Measured: 450.08; <semantics>α4β1IC50=<20nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 20 \ nM: \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoro methoxy)biphenyl-3-yl)propanoate 1-461 (MS [M+H+]+: Calculated: 506.15; Measured: 506.06; <semantics>α4β1 IC50=<200 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 200 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',3'- dimethyl biphenyl-3-yl)propanoate 1-462 (MS [M+H+]+: Calculated: 450.20; Measured: 450.10; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoro methyl)biphenyl-3-yl)propanoate 1-461 (MS [M+H+]+: Calculated: 490.16; Measured: 490.08; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = < 200 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = nd; sodium 3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-oxo-1- phenyl-1,6-dihydropyridin-3-yl)propanoate 1-463 (MS [M+H+]+: Calculated: 439.16; Measured: 438.98; <semantics>α4β1IC50=<200nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 200 \ \text{nM}< / annotation>< / semantics>: <semantics>α4β7IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \ \text{IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(2',6'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate 1-464 (MS [M+H+]+: Calculated: 458.15; Measured: 458.01; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- fluoro biphenyl-3-yl)propanoate 1-465 (MS [M+H+]+: Calculated: 440.16; Measured: 440.05; <semantics>α4β1IC50=<20nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 20 \ \text{nM} : \alpha 4\beta 7 \ \text{IC}_{50} = \text{nd};< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- fluoro biphenyl-3-yl)propanoate 1-466 (MS [M+H+]+: Calculated: 440.16; Measured: 440.01; <semantics>α4β1IC50=<20nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 20 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoro methoxy)biphenyl-3-yl)propanoate 1-467 (MS [M+H+]+: Calculated: 506.15; Measured: 505.97; <semantics>α4β11C50=<200<annotation encoding="application / x-tex">\alpha 4\beta 11C_{50} = < 200< / annotation>< / semantics> nM: <semantics>α4β7<annotation encoding="application / x-tex">\alpha 4\beta 7< / annotation>< / semantics> lC50 = nd; sodium (S)-3-(2',4'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-468 (MS [M+H+]+: Calculated: 482.19; Measured: 481.99; <semantics>α4β1IC50=<200nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 200 \ \text{nM}< / annotation>< / semantics>: <semantics>α4β7IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \ \text{IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3',4'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-469 (MS [M+H+]+: Calculated: 482.19; Measured: 482.00; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6'- dimethyl biphenyl-3-yl)propanoate 1-470 (MS [M+H+]+: Calculated: 450.20; Measured: 449.97; <semantics>α4β1IC50=<20nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 20 \ \text{nM}< / annotation>< / semantics>: <semantics>α4β7IC50=<200nM<annotation encoding="application / x-tex">\alpha 4\beta 7 \ \text{IC}_{50} = < 200 \ \text{nM}< / annotation>< / semantics>; sodium 3-(4'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-471 (MS [M+H+]+: Calculated: 456.13; Measured: 455.91; α4β1 IC50 <semantics>=<annotation encoding="application / x-tex">=< / annotation>< / semantics> < 200 nM: <semantics>α4β7IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 IC_{50} = nd< / annotation>< / semantics>; sodium 3-(3'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-472 (MS [M+H+]+: Calculated: 456.13; Measured: 455.95; α4β1 IC50 <semantics>=<200 nM:α4β7 IC50=nd;<annotation encoding="application / x-tex">= < 200 \text{ nM}: \alpha 4\beta 7 \text{ IC}_{50} = \text{nd};< / annotation>< / semantics> sodium 3-(2'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-473 (MS [M+H+]+: Calculated: 456.13; Measured: 455.93; α4β1 IC50 <semantics>=<20 nM:α4β7 IC50=nd;<annotation encoding="application / x-tex">= < 20 \text{ nM}: \alpha 4\beta 7 \text{ IC}_{50} = \text{nd};< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoro methyl)biphenyl-3-yl)propanoate 1-474 (MS [M+H+]+: Calculated: 490.16; Measured: 489.96; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = < 200 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = nd; sodium (S)-3-(5,6-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-475 (MS [M+H+]+: Calculated: 482.19; Measured: 481.95; <semantics>α4β1 IC50=<200 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 200 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridin-3-yl)phenyl)propanoate 1-476 (MS [M+H+]+: Calculated: 453.18; Measured: 452.96; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = nd; sodium (S)-3-(2',5'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-477 (MS [M+H+]+: Calculated: 482.19; Measured: 481.96; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 200 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium 3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyrimidin-5-yl) phenyl)propanoate 1-478 (MS [M+H+]+: Calculated: 424.16; Measured: 423.92; <semantics>α4β1 IC50=<200 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 200 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(2',6'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-479 (MS [M+H+]+: Calculated: 482.19; Measured: 481.95; <semantics>α4β1 IC50=<200 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 200 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylfuran-2-yl)propanoate 1-482 (MS [M+H+]+: Calculated: 412.15; Measured: 411.90; α4β1 <semantics>IC50=<200 nM<annotation encoding="application / x-tex">IC_{50} = < 200 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 IC_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-3-(3-(1,5-dimethyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-483 (MS [M+H+]+: Calculated: 439.20 Measured: 438.95; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-486 (MS [M+H+]+: Calculated: 490.09; Measured: 489.87; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = < 200 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = nd; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-487 (MS [M+H+]+: Calculated: 458.15; Measured: 458.02; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = > 200 nM; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-488 (MS [M+H+]+: Calculated: 444.14; Measured: 443.94; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = >200 nM sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-2'-methylbiphenyl-3-yl)propanoate 1-489 (MS [M+H+]+: Calculated: 466.20; Measured: 465.97; <semantics>α4β1 IC50=<200 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 200 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5'- methoxy-2'-methylbiphenyl-3-yl)propanoate 1-490 (MS [M+H+]+: Calculated: 466.20; Measured: 465.96; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 200 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium 3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(2,2,2- trifluoro ethoxy)biphenyl-3-yl)propanoate 1-491 (MS [M+H+]+: Calculated: 520.17; Measured: 519.91; <semantics>α4β1 IC50=<200 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 200 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- ethyl biphenyl-3-yl)propanoate 1-492 (MS [M+H+]+: Calculated: 450.20; Measured: 449.95; <semantics>α4β1IC50=<20nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 20 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- fluoro biphenyl-3-yl)propanoate 1-493 (MS [M+H+]+: Calculated: 440.16; Measured: 439.93; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-oxido-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoate 1-494 (MS [M+H+]+: Calculated: 430.12; Measured: 429.89; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 <semantics>=<20 nM<annotation encoding="application / x-tex">= < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3',4'- dimethyl biphenyl-3-yl)propanoate 1-495 (MS [M+H+]+: Calculated: 450.20; Measured: 449.97; <semantics>α4β1IC50=<200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 200 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(2',3'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-496 (MS [M+H+]+: Calculated: 458.15; Measured: 457.90; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 200 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- fluoro-3'-methylbiphenyl-3-yl)propanoate 1-497 (MS [M+H+]+: Calculated: 454.18; Measured: 453.91; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = < 200 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> = nd; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(1- phenyl-1H-pyrrol-2-yl)propanoate 1-498 (MS [M+H+]+: Calculated: 411.17; Measured: 410.87; <semantics>α4β1IC50=>200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = > 200 \ nM: \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-499 (MS [M+H+]+: Calculated: 456.13; Measured: 455.89; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7IC50 = nd; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2- methyl biphenyl-3-yl)propanoate 1-500 (MS [M+H+]+: Calculated: 436.19; Measured: 435.94; <semantics>α4β1IC50=>200nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = > 200 \ nM: \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(3'-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-501 (MS [M+H+]+: Calculated: 438.17; Measured: 437.93; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-502 (MS [M+H+]+: Calculated: 436.19; Measured: 436.03; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = < 200 nM; sodium 3-(5'-chloro-2',4'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-503 (MS [M+H+]+: Calculated: 492.11; Measured: 491.83; <semantics>α4β1 IC50=<200 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 200 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(2',3'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-504 (MS [M+H+]+: Calculated: 482.19; Measured: 482.01; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoate 1-505 (MS [M+H+]+: Calculated: 408.16; Measured: 407.93; α4β1 IC50 <semantics>=<20 nM<annotation encoding="application / x-tex">= < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-506 (MS [M+H+]+: Calculated: 442.12; Measured: 441.85; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-507 (MS [M+H+]+: Calculated: 397.15; Measured: 396.90; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(6-methoxypyridin-3-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-508 (MS [M+H+]+: Calculated: 439.16; Measured: 439.01; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7IC50 = nd; sodium (S)-3-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-509 (MS [M+H+]+: Calculated: 456.16; Measured: 456.00; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoro methoxy) biphenyl-3-yl)propanoate 1-510 (MS [M+H+]+: Calculated: 492.14; Measured: <semantics>491.97<annotation encoding="application / x-tex">491.97< / annotation>< / semantics>; <semantics>α4β11C50=<20<annotation encoding="application / x-tex">\alpha 4\beta 11C_{50} = < 20< / annotation>< / semantics> nM: <semantics>α4β71C50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 1C_{50} = \text{nd}< / annotation>< / semantics>; sodium 3-(2',4'-dichlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-511 (MS [M+H+]+: Calculated: 490.09; Measured: 489.97; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 200 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoro methoxy)biphenyl-3-yl)propanoate 1-512 (MS [M+H+]+: Calculated: 492.14; Measured: 492.00; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-2,5,6,7- tetrahydro-1H-cyclopenta[b]pyridin-3-yl)ureido)propanoate 1-513 (MS [M+H+]+: Calculated: 484.17; Measured: 484.01; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7IC50 = nd; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoro methoxy)biphenyl-3-yl)propanoate 1-514 (MS [M+H+]+: Calculated: 492.14; Measured: 492.02; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-methyl-7-oxido-5-oxo-4,5- dihydrothieno[3,2-b]pyridin-6-yl)ureido)propanoate 1-515 (MS [M+H+]+: Calculated: 500.11; Measured: 499.95; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-516 (MS [M+H+]+: Calculated: 452.15; Measured: 452.00; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-517 (MS [M+H+]+: Calculated: 466.16; Measured: 466.02; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1H-indazol-1-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-518 (MS [M+H+]+: Calculated: 448.16; Measured: 448.05; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(2',4'-difluoro-6-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo- 1,2-dihydro pyridin-3-yl)ureido)propanoate 1-519 (MS [M+H+]+: Calculated: 474.15; Measured: <semantics>474.06<annotation encoding="application / x-tex">474.06< / annotation>< / semantics>; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenyl thiophen-2-yl)propanoate 1-520 (MS [M+H+]+: Calculated: 428.13; Measured: 427.92; <semantics>α4β1IC50=<20nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 20 \ \text{nM} : \alpha 4\beta 7 \ \text{IC}_{50} = \text{nd};< / annotation>< / semantics> sodium (S)-3-(3-(1-ethyl-1H-indol-6-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-521 (MS [M+H+]+: Calculated: 475.20; Measured: 475.10; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1H-pyrazol-1-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-522 (MS [M+H+]+: Calculated: 398.15; Measured: 398.02; <semantics>α4β11C50=<20<annotation encoding="application / x-tex">\alpha 4\beta 11C_{50} = < 20< / annotation>< / semantics> nM: a4b7 <semantics>IC50=nd<annotation encoding="application / x-tex">IC_{50} = nd< / annotation>< / semantics>; sodium (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-523 (MS [M+H+]+: Calculated: 450.09; Measured: 449.92; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate 1-524 (MS [M+H+]+: Calculated: 468.18; Measured: 468.05; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydro- 1,8-naphthyridin-3-yl)ureido)propanoate 1-526 (MS [M+H+]+: Calculated: 495.15; Measured: 494.96; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 200 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7IC50 = nd; sodium (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-527 (MS [M+H+]+: Calculated: 482.19; Measured: 482.02; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = > 200 nM; sodium (S)-3-(4-(3-methoxyphenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-528 (MS [M+H+]+: Calculated: 444.12; Measured: 444.01; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(6-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-529 (MS [M+H+]+: Calculated: 438.17; Measured: 438.02; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(4-(3-chlorophenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-530 (MS [M+H+]+: Calculated: 448.07; Measured: 447.99; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-ethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-531 (MS [M+H+]+: Calculated: 458.15; Measured: 458.02; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (thiophen-2-yl) phenyl)propanoate 1-532 (MS [M+H+]+: Calculated: 414.11; Measured: 414.00; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(6-methoxy-2',6'-dimethylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-533 (MS [M+H+]+: Calculated: 466.20; Measured: 466.01; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=<200 nM<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = < 200 \text{ nM}< / annotation>< / semantics>; sodium (S)-3-(3'-chloro-6-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-534 (MS [M+H+]+: Calculated: 472.13; Measured: <semantics>472.00<annotation encoding="application / x-tex">472.00< / annotation>< / semantics>; α4β1 IC50 = < 20 nM: α4β7 IC50 = nd; sodium (S)-3-(6-methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-535 (MS [M+H+]+: Calculated: 522.15; Measured: 521.95; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(6-methoxy-4'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-536 (MS [M+H+]+: Calculated: 522.15; Measured: 521.98; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(2',6'-dichlorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-537 (MS [M+H+]+: Calculated: 476.08; Measured: 475.94; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = < 200 nM; sodium (S)-3-(3-(5-chlorothiophen-2-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-538 (MS [M+H+]+: Calculated: 448.07; Measured: 447.92; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-539 (MS [M+H+]+: Calculated: 398.15; Measured: 398.07; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(4- methyl thiophen-3-yl)phenyl)propanoate 1-540 (MS [M+H+]+: Calculated: 428.13; Measured: 427.96; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(2',4'-difluoro-6-methylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-541 (MS [M+H+]+: Calculated: 458.15; Measured: 457.96; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3'-methoxy-6-methylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-542 (MS [M+H+]+: Calculated: 452.18; Measured: 452.02; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-(2,6- dimethyl phenyl)thiophen-2-yl)propanoate 1-543 (MS [M+H+]+: Calculated: 442.14; Measured: 441.91; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1H-pyrrol-3-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydro pyridin-3-yl)ureido)propanoate 1-544 (MS [M+H+]+: Calculated: 397.15; Measured: 397.00; <semantics>α4β1IC50=<20nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 20 \ \text{nM} : \alpha 4\beta 7 \ \text{IC}_{50} = \text{nd};< / annotation>< / semantics> sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trimethyl biphenyl-3-yl)propanoate 1-545 (MS [M+H+]+: Calculated: 450.20; Measured: 450.06; <semantics>α4β1IC50=<20nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 20 \ \text{nM} : \alpha 4\beta 7 \ \text{IC}_{50} = \text{nd};< / annotation>< / semantics> sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'— trifluoro biphenyl-3-yl)propanoate 1-546 (MS [M+H+]+: Calculated: 462.13; Measured: 462.01; <semantics>α4β1IC50=<20nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 20 \ \text{nM} : \alpha 4\beta 7 \ \text{IC}_{50} = \text{nd};< / annotation>< / semantics> sodium (S)-3-(6-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-547 (MS [M+H+]+: Calculated: 456.16; Measured: 456.04; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1-methyl-1H-pyrazol-4-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-548 (MS [M+H+]+: Calculated: 412.16; Measured: 411.98; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(2-methyl-5-oxido-3-oxo-2,3- dihydropyridazin-4-yl)ureido)propanoate 1-549 (MS [M-H+]-: Calculated: 443.12; Measured: 443.10; <semantics>α4β1IC50=<20<annotation encoding="application / x-tex">\alpha 4\beta 1IC_{50} = < 20< / annotation>< / semantics> nM: <semantics>α4β7IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 IC_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6'- dimethylbiphenyl-3-yl)propanoate 1-550 (MS [M+H+]+: Calculated: 450.20; Measured: 450.00; <semantics>α4β1IC50=<20nM:α4β7IC50=<200nM;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 20 \ \text{nM} : \alpha 4\beta 7 \ \text{IC}_{50} = < 200 \ \text{nM};< / annotation>< / semantics> sodium (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-551 (MS [M+H+]+: Calculated: 482.19; Measured: 481.99; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-552 (MS [M+H+]+: Calculated: 464.11; Measured: 463.98; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy biphenyl-3-yl)propanoate 1-553 (MS [M+H+]+: Calculated: 452.18; Measured: 452.01; <semantics>α4β11C50=<20 nM:α4β71C50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 11C_{50} = < 20 \text{ nM}: \alpha 4\beta 7 1C_{50} = \text{nd};< / annotation>< / semantics> sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-554 (MS [M+H+]+: Calculated: 536.16; Measured: 535.94; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3'-chloro-6-methylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-555 (MS [M+H+]+: Calculated: 456.13; Measured: 456.00; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-556 (MS [M+H+]+: Calculated: 456.13; Measured: 455.99; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(6-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-557 (MS [M+H+]+: Calculated: 444.14; Measured: 443.99; <semantics>α4β1 IC50=>200 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = > 200 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(5-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate 1-558 (MS [M+H+]+: Calculated: 438.17; Measured: 437.99; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3-(furan-3-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-559 (MS [M+H+]+: Calculated: 398.13; Measured: 397.93; α4β1 IC50 <semantics>=<20 nM<annotation encoding="application / x-tex">= < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4 \beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-560 (MS [M+H+]+: Calculated: 427.16; Measured: 426.98; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = > 200 nM; sodium (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-561 (MS [M+H+]+: Calculated: 454.18; Measured: 453.99; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = < 20 nM; sodium (S)-3-(5-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-562 (MS [M+H+]+: Calculated: 450.09; Measured: 449.95; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = > 200 nM; sodium (S)-3-(5-(3-methoxyphenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-563 (MS [M+H+]+: Calculated: 444.12; Measured: 443.90; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate 1-564 (MS [M+H+]+: Calculated: 468.18; Measured: 467.99; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7IC50 = nd; sodium (S)-3-(5-methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-565 (MS [M+H+]+: Calculated: 522.15; Measured: 521.95; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo- 1,2-dihydro pyridin-3-yl)ureido)propanoate 1-566 (MS [M+H+]+: Calculated: 474.15; Measured: 473.92; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7IC50 = nd; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-568 (MS [M+H+]+: Calculated: 536.16; Measured: 535.96; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-methylbiphenyl-3-yl)propanoate 1-569 (MS [M+H+]+: Calculated: 466.20; Measured: 465.99; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate 1-570 (MS [M+H+]+: Calculated: 426.15; Measured: 425.98; α4β1 IC50 <semantics>=<20 nM<annotation encoding="application / x-tex">= < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- phenylpyridin-2-yl)propanoate 1-571 (MS [M+H+]+: Calculated: 409.15; Measured: 408.99; <semantics>α4β1IC50=<20nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ IC_{50} = < 20 \ nM: \ \alpha 4\beta 7 \ IC_{50} = nd;< / annotation>< / semantics> sodium (S)-3-(5-methyl-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-572 (MS [M+H+]+: Calculated: 506.15; Measured: 506.12; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=>200 nM<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = > 200 \text{ nM}< / annotation>< / semantics>; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethyl biphenyl-3-yl)propanoate 1-573 (MS [M+H+]+: Calculated: 450.20; Measured: 450.01; <semantics>α4β1IC50=<20nM:α4β7IC50=nd;<annotation encoding="application / x-tex">\alpha 4\beta 1 \ \text{IC}_{50} = < 20 \ \text{nM} : \alpha 4\beta 7 \ \text{IC}_{50} = \text{nd};< / annotation>< / semantics> sodium (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate 1-574 (MS [M+H+]+: Calculated: 458.15; Measured: 457.95; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-575 (MS [M+H+]+: Calculated: 472.17; Measured: 471.96; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = nd; sodium (S)-3-(6-methyl-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate 1-576 (MS [M+H+]+: Calculated: 506.15; Measured: 506.00; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate 1-577 (MS [M+H+]+: Calculated: 520.17; Measured: 520.10; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- fluoro-2',6'-dimethylbiphenyl-3-yl)propanoate 1-578 (MS [M+H+]+: Calculated: 468.19; Measured: 468.03; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / semantics>: <semantics>α4β7 IC50=nd<annotation encoding="application / x-tex">\alpha 4\beta 7 \text{ IC}_{50} = \text{nd}< / annotation>< / semantics>; sodium (S)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate 1-579 (MS [M+H+]+: Calculated: 466.20; Measured: 466.05; <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>1 IC50 = < 20 nM: <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>4<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>7 IC50 = < 20 nM; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate 1-580 (MS [M+H+]+: Calculated: 480.21; Measured: 480.03; <semantics>α4β1 IC50=<20 nM<annotation encoding="application / x-tex">\alpha 4\beta 1 \text{ IC}_{50} = < 20 \text{ nM}< / annotation>< / s...

Claims

<pat:ClaimStatement>WHAT IS CLAIMED IS:< / pat:ClaimStatement> <pat:Claims com:id="claims"> <pat:Claim com:id="CLM-00001"> <pat:ClaimNumber>1< / pat:ClaimNumber> <pat:ClaimText>1. A compound of formula I having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I) wherein R1 is [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] , [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] or , <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics> and <semantics>R3<annotation encoding="application / x-tex">R^3< / annotation>< / semantics> are independently hydrogen or <semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics> alkyl; <semantics>R4<annotation encoding="application / x-tex">R^4< / annotation>< / semantics> is H or <semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics> alkyl; R5 is phenyl, or aryl, any of which is substituted with one or more of C1-4 alkyl, alkoxy, oxo, halogen, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; R6 is phenyl, or aryl, any of which is substituted with one or more of C1-4 alkyl, alkoxy, halogen, oxo, acetyl, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; <semantics>R7<annotation encoding="application / x-tex">R^7< / annotation>< / semantics> is H or <semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics> alkyl; R8, and R9 are independently hydrogen, C1-4 alkyl, or hydroxyl; and R10 is hydroxyl; or a pharmaceutically acceptable salt or stereoisomers thereof. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00002"> <pat:ClaimNumber>2< / pat:ClaimNumber> <pat:ClaimText>2. The compound of claim 1, wherein R2 and R3 are each hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00003"> <pat:ClaimNumber>3< / pat:ClaimNumber> <pat:ClaimText>3. The compound of claim 1, wherein R4 is hydrogen, methyl, ethyl or t-butyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00004"> <pat:ClaimNumber>4< / pat:ClaimNumber> <pat:ClaimText>4. The compound of claim 1, wherein R7 is hydrogen, methyl or ethyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00005"> <pat:ClaimNumber>5< / pat:ClaimNumber> <pat:ClaimText>5. The compound of claim 1, wherein R8 and R9 are independently hydrogen or methyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00006"> <pat:ClaimNumber>6< / pat:ClaimNumber> <pat:ClaimText>6. The compound of claim 1, wherein R10 is hydroxyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00007"> <pat:ClaimNumber>7< / pat:ClaimNumber> <pat:ClaimText>7. The compound of claim 1, wherein the steroisomer is of the (S)-configuration. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00008"> <pat:ClaimNumber>8< / pat:ClaimNumber> <pat:ClaimText>8. The compound of claim 1, wherein the compound of formula I is the compound of formula I A having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (IA) wherein, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined in claim 1; or a pharmaceutically acceptable salt or stereoisomers thereof. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00009"> <pat:ClaimNumber>9< / pat:ClaimNumber> <pat:ClaimText>9. The compound of claim 1, wherein the compound of formula I is the compound of formula I B having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I B) wherein, R2, R3, R4, R5, R6, R7, R9 and R10 are as defined in claim 1; or the pharmaceutically acceptable salt or stereoisomers thereof. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00010"> <pat:ClaimNumber>10< / pat:ClaimNumber> <pat:ClaimText>10. The compound of claim 1, wherein the compound of formula I is the compound of formula I C having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I C) wherein, R2, R3, R4, R5, R6, R7and R10 are as defined in claim 1; or a pharmaceutically acceptable salt or stereoisomers thereof. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00011"> <pat:ClaimNumber>11< / pat:ClaimNumber> <pat:ClaimText>11. The compound of claim 1, wherein the compound of formula I is the compound of formula I D having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I D) wherein, R2, R3, R4, R5, R6, R7 and R10 are as defined in claim 1; or a pharmaceutically acceptable salt or stereoisomers thereof. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00012"> <pat:ClaimNumber>12< / pat:ClaimNumber> <pat:ClaimText>12. The compound of claim 1, wherein the compound of formula I is the compound of formula IE having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I E) wherein, R2, R3, R4, R5, R6, R7 and R10 are as defined in claim 1; or a pharmaceutically acceptable salt or stereoisomers thereof. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00013"> <pat:ClaimNumber>13< / pat:ClaimNumber> <pat:ClaimText>13. The compound of claim 1, wherein the compound of formula I is the compound of formula IF having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I F) wherein, R2, R3, R4, R5, R6, R9 and R10 are as defined in claim 1; or a pharmaceutically acceptable salt or stereoisomers thereof. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00014"> <pat:ClaimNumber>14< / pat:ClaimNumber> <pat:ClaimText>14. The compound of claim 1, wherein the pharmaceutically acceptable salt is the mono or disodium sodium salt. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00015"> <pat:ClaimNumber>15< / pat:ClaimNumber> <pat:ClaimText>15. A pharmaceutical composition, comprising at least one compound of claim 1 and one or more pharmaceutically acceptable carriers. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00016"> <pat:ClaimNumber>16< / pat:ClaimNumber> <pat:ClaimText>16. A compound of formula I having a chemical structure of [Image disponible dans le document PDF, Image available in the PDF document] (I) wherein R1 is [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] , , [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] or <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics> and <semantics>R3<annotation encoding="application / x-tex">R^3< / annotation>< / semantics> are hydrogen; R4 is hydrogen; methyl, ethyl or t-butyl; R5 is phenyl, or aryl, any of which is substituted with one or more of C1-4 alkyl, alkoxy, oxo, halogen, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, -OCF2CF2H, -O(C3-6 cycloalkyl), -OCH2CF3, thioalkoxy, dialkylamino, C3-6 cycloalkyl or haloalkyl; R6 is phenyl, or aryl, any of which is substituted with one or more of hydrogen, C1-4 alkyl, alkoxy, halogen, oxo, acetyl, haloalkoxy, -CF3, hydroxyl, -OCF3, aryl, -OCF2H, - <semantics>OCF2CF2H<annotation encoding="application / x-tex">OCF_2CF_2H< / annotation>< / semantics>, <semantics>−O(C3−6<annotation encoding="application / x-tex">-O(C_{3-6}< / annotation>< / semantics> cycloalkyl), <semantics>−OCH2CF3<annotation encoding="application / x-tex">-OCH_2CF_3< / annotation>< / semantics>, thioalkoxy, dialkylamino, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl or haloalkyl; R7 is hydrogen, methyl or ethyl; and R8 and R9 are independently hydrogen or methyl; or a pharmaceutically acceptable salt or stereoisomers thereof. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00017"> <pat:ClaimNumber>17< / pat:ClaimNumber> <pat:ClaimText>17. A compound that is: ethyl (S)-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydro pyridin-3- yl)ureido)propanoate; ethyl (S)-3-(biphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; ethyl 3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(2- oxo-3-phenylpyridin-1(2H)-yl)phenyl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-3-yl)propanoate; ethyl (S)-3-(2'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; ethyl (S)-3-(6-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; ethyl (S)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-3-yl)propanoate; ethyl (S)-3-(3-1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl biphenyl-3-yl)propanoate; ethyl 3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydro pyridin-3-yl) ureido)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(2',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methyl biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxy biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methyl biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyridin-3-yl) phenyl)propanoate; ethyl (S)-3-(3',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxy biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2' – methoxy biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyrazin- 2-yl) phenyl)propanoate, ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoro methoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(3',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(2',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoro methoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(2',3'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-oxo-1- phenyl-1,6-dihydropyridin-3-yl)propanoate; ethyl (S)-3-(2',6'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(4′<annotation encoding="application / x-tex">(4'< / annotation>< / semantics>-fluorobiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4−hydroxy−1,5−dimethyl−2−oxo−1,2−dihydroxy−1,5−dimethyl−2−oxo−1,2−dihydroxy−1,5−dimethyl−2−oxo−1,2−dihydroxy−1,5−dimethyl−2−oxo−1,2−dihydroxy−1,5−dimethyl−2−oxo−1,2−dihydroxy−1,<annotation encoding="application / x-tex">(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydroxy-1,5-dimethyl-2-oxo-1,2-dihydroxy-1,5-dimethyl-2-oxo-1,2-dihydroxy-1,5-dimethyl-2-oxo-1,2-dihydroxy-1,5-dimethyl-2-oxo-1,2-dihydroxy-1,< / annotation>< / semantics> pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoro methoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(2',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl 3-(4'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; ethyl (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; ethyl 3-(2'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoro methyl)biphenyl-3-yl)propanoate; ethyl (S)-3-(5,6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridin-3-yl)phenyl)propanoate; ethyl (S)-3-(2',5'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyrimidin-5-yl)phenyl)propanoate; ethyl (S)-3-(2',6'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydro pyridin-3-yl)ureido) propanoate; ethyl 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylfuran-2-yl)propanoate; ethyl (S)-3-(3-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; ethyl 3-(3'-chloro-4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl 3-(2',3'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-2'-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5'- methoxy-2'-methylbiphenyl-3-yl)propanoate; ethyl 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(2,2,2- trifluoro ethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(2'-ethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoate; ethyl (S)-3-(3',4'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-di hydropyridin -3-yl)ureido)propanoate; ethyl (S)-3-(2',3'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(4'-fluoro-3'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(1- phenyl-1H-pyrrol-2-yl)propanoate; ethyl (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2- methyl biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy biphenyl-3-yl)propanoate; ethyl (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl 3-(5'-chloro-2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(2',3'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl) ureido)propanoate; ethyl (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; ethyl (S)-3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridin-3-yl)phenyl)propanoate; ethyl (S)-3-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-(trifluoro methoxy)biphenyl-3-yl)propanoate; ethyl 3-(2',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'-(trifluoro methoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-2,5,6,7- tetrahydro-1H-cyclopenta[b]pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-(trifluoro methoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-4-methyl-5-oxo-4,5- dihydrothieno[3,2-b]pyridin-6-yl)ureido)propanoate; ethyl (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(1H-indazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(2',4'-difluoro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenylthiophen-2-yl)propanoate; ethyl (S)-3-(3-(1-ethyl-1H-indol-6-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(1H-pyrazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl 3-(2',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro- 1,8-naphthyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-(3- methoxy phenyl)thiophen-2-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy biphenyl-3-yl)propanoate; ethyl (S)-3-(4-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2′,4′<annotation encoding="application / x-tex">(2',4'< / annotation>< / semantics>-difluorobiphenyl-3-yl)-3-<semantics>(3−(1−ethyl−4−hydroxy−2−oxo−1,2−dihydroxy−2−oxo−1,2−dihydroxy−2−oxo−1,2−dihydroxy−2−oxo−1,2−dihydroxy−2−oxo−1,2−dihydroxy−2−oxo−1,2−dihydroxy−2−oxo−1,2−dihydroxy−2−oxo−1,2−dihydr<annotation encoding="application / x-tex">(3-(1-ethyl-4-hydroxy-2-oxo-1,2-dihydroxy-2-oxo-1,2-dihydroxy-2-oxo-1,2-dihydroxy-2-oxo-1,2-dihydroxy-2-oxo-1,2-dihydroxy-2-oxo-1,2-dihydroxy-2-oxo-1,2-dihydroxy-2-oxo-1,2-dihydr< / annotation>< / semantics> pyridin-3-yl) ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (thiophen-2-yl) phenyl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-(3'-chloro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxy-4'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(2',6'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(5-chlorothiophen-2-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(4- methylthiophen-3-yl)phenyl)propanoate; ethyl (S)-3-(2',4'-difluoro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-(4-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(1H-pyrrol-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trifluorobiphenyl-3-yl)propanoate; [Image disponible dans le document PDF, Image available in the PDF document] ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(1- methyl-1H-pyrazol-4-yl)phenyl)propanoate; [Image disponible dans le document PDF, Image available in the PDF document] ethyl (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(3'-chloro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-6-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(furan-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoate; ethyl (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(5-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- methoxy phenyl)thiophen-2-yl)propanoate; ethyl (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo - 1,2-dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- phenylpyridin-2-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methyl- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethyl biphenyl-3-yl)propanoate; ethyl (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methyl- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate; ethyl (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-5-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5- tetrahydroindolizin-6-yl) ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-methyl- [2,3'-bithiophen]-5-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl-[2,3'-bithiophen]-5-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-5-methylbiphenyl-3-yl)propanoate; ethyl (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluoro biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluoro biphenyl-3-yl)propanoate; ethyl (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] ethyl 3-(3'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; ethyl 3-(4'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenyl thiophen-2-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenyl thiophen-2-yl)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5- tetrahydroindolizin-6-yl) ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiazol- 2-yl) phenyl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-(trifluoromethoxy)biphenyl-3-yl)propanoate; ethyl (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-4-yl)propanoate; ethyl (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin- 2-yl) phenyl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridazin-3-yl)phenyl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylpyridin-3-yl)propanoate; (S)-ethyl 3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; tert-butyl (S)-3-(biphenyl-4-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoate; ethyl (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6'- methoxy pyridin-2-yl)phenyl)propanoate; ethyl (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxy biphenyl-3-yl)propanoate; ethyl (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; ethyl 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl) ureido)propanoate; ethyl 3-(3-bromophenyl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; ethyl (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate; (S)-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; (S)-3-(biphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; 3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(2-oxo-3- phenyl pyridin-1(2H)-yl)phenyl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoic acid; (S)-3-(2'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(6-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-3-yl)propanoic acid; (S)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl biphenyl-3-yl)propanoic acid; 3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(2',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin-3- yl) phenyl)propanoic acid; (S)-3-(3',5'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoromethyl) biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; (S)-3-(3',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(2',5'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(2',3'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-oxo-1-phenyl- 1,6-dihydropyridin-3-yl)propanoic acid; (S)-3-(2',6'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3′<annotation encoding="application / x-tex">(3'< / annotation>< / semantics>-fluorobiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; (S)-3-(2',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3',4'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; 3-(4'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; 3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; 3-(2'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethyl) biphenyl-3-yl)propanoic acid; (S)-3-(5,6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridin-3-yl)phenyl)propanoic acid; (S)-3-(2',5'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyrimidin-5- yl)phenyl) propanoic acid; (S)-3-(2',6'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylfuran-2-yl) propanoic acid; (S)-3-(3-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; 3-(3'-chloro-4'-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; 3-(2',3'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 2'-methylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5'-methoxy- 2'-methylbiphenyl-3-yl)propanoic acid; 3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(2,2,2-trifluoro ethoxy)biphenyl-3-yl)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2′<annotation encoding="application / x-tex">(2'< / annotation>< / semantics>-ethylbiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(2′,4′<annotation encoding="application / x-tex">(2',4'< / annotation>< / semantics>-difluorobiphenyl-3-yl)-3-<semantics>(3−(4−hydroxy−2−oxo−1,2−dihydropyridin−3−yl)<annotation encoding="application / x-tex">(3-(4-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)< / annotation>< / semantics> ureido)propanoic acid; (S)-3-(3',4'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(2',3'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(4'-fluoro-3'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(1-phenyl- 1H-pyrrol-2-yl)propanoic acid; (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2- methylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; 3-(5'-chloro-2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(2',3'-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido)propanoic acid; (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; (S)-3-(3-(1H-pyrrol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridin-3-yl)phenyl)propanoic acid; (S)-3-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; 3-(2',4'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-2,5,6,7-tetrahydro- 1H-cyclopenta[b]pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-4-methyl-5-oxo-4,5- dihydrothieno[3,2-b] pyridin-6-yl)ureido)propanoic acid; (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(1H-indazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(2',4'-difluoro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenylthiophen-2-yl) propanoic acid; (S)-3-(3-(1-ethyl-1H-indol-6-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(3−(1H−pyrazol−1−yl)phenyl)−3−<math>(3−(4−hydroxy−1−methyl−2−oxo−1,2−dihydropyridin−<annotation encoding="application / x-tex">(3-(1H-pyrazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-< / annotation>< / semantics> 3-yl) ureido)propanoic acid; (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin -3-yl)ureido)propanoic acid; (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; 3-(2',5'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8- naphthyridin -3-yl)ureido)propanoic acid; (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-(3- methoxyphenyl) thiophen-2-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methoxybiphenyl-3-yl) propanoic acid; (S)-3-(4-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiophen-2- yl) phenyl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy-2',6'- dimethylbiphenyl-3-yl)propanoic acid; (S)-3-(3'-chloro-6-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy-4'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(2',6'-dichlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(5-chlorothiophen-2-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(4- methylthiophen-3-yl)phenyl)propanoic acid; (S)-3-(2',4'-difluoro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-6- methyl biphenyl-3-yl)propanoic acid; (S)-3-(4-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin -3-yl)ureido)propanoic acid; (S)-3-(3-(1H-pyrrol-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trimethylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6,6'- trifluorobiphenyl-3-yl)propanoic acid; (S)-3-(6-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(1-methyl-1H- pyrazol-4-yl)phenyl)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(5-hydroxy-2-methyl-3-oxo-2,3- dihydropyridazin-4-yl) ureido)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3',6-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(4-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methoxy- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3'-chloro-6-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxybiphenyl-3-yl) propanoic acid; (S)-3-(3-(furan-3-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(5-(2,4-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- methoxyphenyl) thiophen-2-yl)propanoic acid; (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy- 3'-(trifluoromethoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 6-methyl biphenyl-3-yl)propanoic acid 1; (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-phenylpyridin- 2-yl) propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethylbiphenyl-3-yl)propanoic acid; (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methyl-3'- (trifluoromethoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(6-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy-2',6'- dimethylbiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methoxy- 2',6'-dimethylbiphenyl-3-yl)propanoic acid; (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-5- methyl biphenyl-3-yl)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6- yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-methyl-[2,3'- bithiophen]-5-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'-methyl- [2,3'-bithiophen]-5-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 5-methyl biphenyl-3-yl)propanoic acid; (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin -3-yl)ureido)propanoic acid; (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluorobiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluoro biphenyl-3-yl)propanoic acid; (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethyl biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl) propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-3-yl)propanoic acid; (S)-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(3- (trifluoromethoxy) phenyl)thiophen-2-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4-methoxy-2',6'- dimethylbiphenyl-3-yl)propanoic acid; (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(5-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(5-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(5-(3,5-dimethylisoxazol-4-yl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(3,5-dimethylisoxazol-4-yl)phenyl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(2-fluorobiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(6-fluoro-2'-methylbiphenyl-3-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylthiophen-2-yl) propanoic acid; (S)-3-(5-(2,5-difluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-4-yl) propanoic acid; (S)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl)ureido)-3-(5- methoxybiphenyl-3-yl) propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- (trifluoromethyl) biphenyl-3-yl)propanoic acid; (S)-3-(5-(3-chlorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(5-(3-fluorophenyl)thiophen-2-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3- yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-4-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'-methyl-6- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- (trifluoromethoxy) biphenyl-3-yl)propanoic acid; 3-(3'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; 3-(4'-acetylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- phenylthiophen-2-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylthiophen-2-yl)propanoic acid; (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizin-6- yl)ureido) propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiazol-2- yl)phenyl) propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-methyl-3'- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluorobiphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy-6- (trifluoro methoxy)biphenyl-3-yl)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'-methoxy- 6-(trifluoromethoxy)biphenyl-3-yl)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methylbiphenyl-4-yl)propanoic acid; (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin-2- yl)phenyl) propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxypyridazin-3-yl)phenyl)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-phenylpyridin- 3-yl) propanoic acid; (S)-3-(5-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(4-hydroxy-1,6-dimethyl-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoic acid; (S)-3-(biphenyl-4-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido) propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6'- methoxypyridin-2-yl)phenyl)propanoic acid; (S)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxybiphenyl-3-yl)propanoic acid; (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoic acid; (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyrazin-2- yl)phenyl) propanoic acid; 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)ureido) propanoic acid, 3-(3-bromophenyl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoic acid; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] sodium (S)-3-(3',4'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6'- dimethyl biphenyl-3-yl)propanoate; sodium 3-(4'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; sodium 3-(3'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; sodium 3-(2'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- (trifluoro methyl)biphenyl-3-yl)propanoate; sodium (S)-3-(5,6-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6- methoxy pyridin-3-yl)phenyl)propanoate; sodium (S)-3-(2',5'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium 3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyrimidin-5-yl) phenyl)propanoate; sodium (S)-3-(2',6'-dimethoxybiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1-ethyl-5-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium 3-(3',4'-dichlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylfuran-2-yl)propanoate; sodium (S)-3-(3-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; sodium 3-(3'-chloro-4'-fluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium 3-(2',3'-dichlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium 3-(3',5'-dichlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-2'-methylbiphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5'- methoxy-2'-methylbiphenyl-3-yl)propanoate; sodium 3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6-(2,2,2- trifluoro ethoxy)biphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'-ethyl biphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- fluoro biphenyl-3-yl)propanoate; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(4-oxido-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3',4'- dimethyl biphenyl-3-yl)propanoate; sodium (S)-3-(2',3'-difluorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- fluoro-3'-methylbiphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(1- phenyl-1H-pyrrol-2-yl)propanoate; sodium (S)-3-(3'-chlorobiphenyl-3-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl) ureido)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2- methyl biphenyl-3-yl)propanoate; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] sodium (S)-3-(5-methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3',5-dimethoxybiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-methylbiphenyl-3-yl)propanoate; sodium (S)-3-(4-fluorobiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- phenylpyridin-2-yl)propanoate; sodium (S)-3-(5-methyl-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',5,6'- trimethyl biphenyl-3-yl)propanoate; sodium (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(2',4'-difluoro-5-methylbiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(6-methyl-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- methyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(6- fluoro-2',6'-dimethylbiphenyl-3-yl)propanoate; sodium (S)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- methoxy-2',6'-dimethylbiphenyl-3-yl)propanoate; sodium (S)-3-(2',4'-difluoro-5-methoxybiphenyl-3-yl)-3-(3-(1,6-dimethyl-4-oxido-2-oxo- 1,2-dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3'-methoxy-5-methylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium <semantics>(S)−3−(2′,6′−dimethylbiphenyl−3−yl)−3−(3−(7−oxido−5−oxo−1,2,3,5−tetrahydro−1,2,3,5−tetrahydro−1,2,3,5−tetrahydro−1,2,3,5−tetrahydro−1,2,3,5−tetrahydro−1,2,3,5−tetrahydro−1,2,3,5−tetrahydro−1,2,3,5−tetrahydro−1,2,3,5−tetr<annotation encoding="application / x-tex">(S)-3-(2',6'-dimethylbiphenyl-3-yl)-3-(3-(7-oxido-5-oxo-1,2,3,5-tetrahydro-1,2,3,5-tetrahydro-1,2,3,5-tetrahydro-1,2,3,5-tetrahydro-1,2,3,5-tetrahydro-1,2,3,5-tetrahydro-1,2,3,5-tetrahydro-1,2,3,5-tetrahydro-1,2,3,5-tetr< / annotation>< / semantics> indolizin-6-yl) ureido)propanoate; sodium (S)-3-(4'-methyl-2,3'-bithiophen-5-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-di hydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methyl-2,3'-bithiophen-5-yl)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-5-methylbiphenyl-3-yl)propanoate; sodium (S)-3-(5-(2,6-dimethylphenyl)thiophen-2-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5-(2,6- dimethyl phenyl)thiophen-2-yl)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- fluoro-2',6'-dimethylbiphenyl-3-yl)propanoate; sodium (S)-3-(4-fluoro-2',6'-dimethylbiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluoro biphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4,4'- trifluoro biphenyl-3-yl)propanoate; sodium (S)-3-(4-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(4-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4- fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; sodium <semantics>(S)<annotation encoding="application / x-tex">(S)< / annotation>< / semantics>-3-<semantics>(4<annotation encoding="application / x-tex">(4< / annotation>< / semantics>-methoxybiphenyl-3-yl)-3-<semantics>(3<annotation encoding="application / x-tex">(3< / annotation>< / semantics>-<semantics>(1<annotation encoding="application / x-tex">(1< / annotation>< / semantics>-methyl-4-oxido-2-oxo-1,2-dihydro pyridin-3-yl)ureido)propanoate; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenyl thiophen-2-yl)propanoate; sodium (S)-3-(2',4'-difluorobiphenyl-3-yl)-3-(3-(7-oxido-5-oxo-1,2,3,5- tetrahydroindolizin-6-yl) ureido)propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(thiazol- 2-yl) phenyl)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- fluoromethyl-3'-(trifluoromethoxy)biphenyl-3-yl)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',4',5- trifluoro biphenyl-3-yl)propanoate; sodium (S)-3-(3'-methoxy-6-(trifluoromethoxy)biphenyl-3-yl)-3-(3-(1-methyl-4-oxido-2- oxo-1,2-dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3'- methoxy-6-(trifluoromethoxy)biphenyl-3-yl)propanoate; sodium (S)-3-(2',6'-dimethylbiphenyl-4-yl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2'- methyl biphenyl-4-yl)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(2',6'- dimethyl biphenyl-4-yl)propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(pyridin- 2-yl) phenyl)propanoate; sodium (S)-3-(3-(6-methoxypyridazin-3-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydro pyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- phenylpyridin-3-yl)propanoate; sodium (S)-3-(3-(1,6-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(5- fluoro-2',6'-dimethylbiphenyl-3-yl)propanoate; sodium (S)-3-(biphenyl-4-yl)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3- yl)ureido) propanoate; sodium (S)-3-(3-(1-methyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3-(6'- methoxy pyridin-2-yl)phenyl)propanoate; sodium (S)-3-(3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(4'- methoxy biphenyl-3-yl)propanoate; sodium (S)-3-(3-(1H-imidazol-1-yl)phenyl)-3-(3-(1-methyl-4-oxido-2-oxo-1,2- dihydropyridin-3-yl)ureido)propanoate; sodium (S)-3-(3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)ureido)-3-(3- (pyrazin-2-yl) phenyl)propanoate; sodium 3-(3-bromophenyl)-3-(3-(4-hydroxy-1,5-dimethyl-2-oxo-1,2-dihydropyridin-3-yl) ureido)propanoate;or sodium 3-(3-bromophenyl)-3-(3-(1-ethyl-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin- 3-yl) ureido)propanoate. < / pat:ClaimText> < / pat:Claim> < / pat:Claims>