Medicine raw material 5-(allyloxy)-1-fluorine-6-ethyl pyrimidine synthetic method
A technology of allyloxy and ethylpyrimidine, which is applied in the field of synthesis of pharmaceutical raw materials 5--1-fluoro-6-ethylpyrimidine, can solve problems such as the synthesis method of unreported compounds, and achieve a simple and satisfactory synthesis method. Effects of mass production and operational safety
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Publication Date
- 2017-03-22
- Estimated Expiration
- Not applicable · inactive patent
Abstract
Description
technical field
[0001] The invention relates to a method for synthesizing 5-(allyloxy)-1-fluoro-6-ethylpyrimidine as a medical raw material. Background technique
[0002] The synthesis method of 5-(allyloxy)-1-fluoro-6-ethylpyrimidine is the starting material for the synthesis of many drugs, especially the important intermediates of many ethylpyrimidine compounds. There is no report on this compound in China at present. resolve resolution. Contents of the invention
[0003] The object of the present invention is to overcome the above-mentioned shortcomings, and provide a simple, efficient and safe synthetic method for pharmaceutical raw material 5-(allyloxy)-1-fluoro-6-ethylpyrimidine.
[0004] The purpose of the present invention is achieved like this:
[0005] A kind of synthetic method of pharmaceutical raw material 5-(allyloxy)-1-fluoro-6-ethylpyrimidine, with 5-(allyloxy)pyrimidine as raw material, in solvent ethylene glycol ether and pH5-6 Under the action, the sy...
Examples
Embodiment Construction
[0008] The synthetic method of pharmaceutical raw material 5-(allyloxy)-1-fluoro-6-ethylpyrimidine of the present invention is specifically as follows:
[0009] Using 5-(allyloxy)pyrimidine as a raw material, under the action of solvent ethylene glycol ether and pH 5-6, at a temperature of 120°C-150°C, successively generate 5-(allyloxy)pyrimidine through ethylation and fluorine displacement reactions Base)-1-fluoro-6-ethylpyrimidine synthetic method. The purity of this crude product can meet the general reaction requirements and can be directly put into the reaction.