Blood oxygenation flow device

Abstract

The present invention discloses a blood oxygenation circulation device, including a boost module and an oxygenation module. The oxygenation module includes an oxygenator housing, a water film isolation plate, an air-water isolation plate, and an air-blood isolation plate. A central blood channel is formed inside the air-blood isolation plate. A pressure regulating area and a blood collection area are formed between the air-blood isolation plate and the air-water isolation plate. An air-blood barrier is provided between the pressure regulating area and the blood collection area. A heat exchange area is formed between the air-water isolation plate and the water film isolation plate. An oxygenation area is formed between the water film isolation plate and the oxygenator housing. Blood circulation channels are provided on the water film isolation plate and the air-water isolation plate. An annular gas collection area is provided between the oxygenator housing and the oxygenation area. The device is small in size, reduces the pipelines between the pump and the lung, and improves the efficiency of membrane lung use. Two pressure adjustments can avoid the overflow of micro bubbles in the blood caused by blood temperature change, and also avoid overoxidation caused by excessive concentration of air and oxygen mixed gas, thereby ensuring oxygenation stability and safety.

Description

Technical Field

[0001] The present invention relates to the field of medical equipment, and in particular to a blood oxygenation circulation device. Background Art

[0002] Respiratory diseases are the most common systemic diseases in the world, and the main cause of critical respiratory diseases is acute lung injury (ALI). ALI is caused by various direct and indirect injury factors that damage alveolar epithelial cells and capillary endothelial cells, resulting in diffuse pulmonary interstitial and alveolar edema, leading to acute hypoxic respiratory insufficiency. Its pathophysiological characteristics are reduced lung volume, reduced lung compliance, and ventilation / perfusion imbalance. Clinically, it manifests as progressive hypoxemia and respiratory distress. Lung imaging shows non-uniform exudative lesions. Severe cases are called acute respiratory distress syndrome (ARDS). According to the ALI / ARDS diagnostic criteria proposed by the European and American Joint Conference in 1994, the incidence of ALI and ARDS in the United States in 2005 was 79 / 100,000 and 59 / 100,000 per year, respectively. In recent years, the incidence of ALI / ARDS can be as high as 25% to 50% in severe infections, 40% in massive blood transfusions, and 11% to 25% in multiple traumas. In addition, the longer the risk factors last, the higher the incidence of ALI / ARDS. When the risk factors last for 24, 48, and 72 hours, the incidence of ARDS is 76%, 85%, and 93%, respectively, making it the primary disease threatening human health.

[0003] ECMO (Extracorporeal Membrane Oxygenation), also known as "ECMO" or "artificial lung", is a medical emergency device. ECMO was first successfully used in the treatment of patients with acute respiratory distress syndrome in 1972 by Robert H. Bartlett, a surgeon at the University of Michigan. With the advancement of medicine, its technology has become more mature. ECMO is mainly used in clinical practice to provide continuous extracorporeal respiration and circulation for patients with severe cardiopulmonary failure, such as heart failure, acute respiratory distress syndrome and other diseases. It can also be used for short-term cardiopulmonary support. According to the needs of patients, complete cardiopulmonary function replacement (VA ECMO, veno-arterial mode) or only lung function replacement (VV ECMO, veno-venous mode) is performed to maintain the patient's life and buy time for heart and lung transplantation, functional recovery, and even to maintain the patient's life.

[0004] The ECMO system usually includes a blood pump that provides input flow, a membrane oxygenator that supplies oxygen, connecting pipes coated with heparin and pre-filled, a variable temperature water tank that maintains blood temperature, and various detection equipment, such as blood oxygen saturation, venous line negative pressure detection, etc. The ECMO system on the market is large in size, complex in structure and operation, and is mostly used for long-term life support, which is not conducive to emergency rescue. At the same time, due to its large size and complex operation, another problem brought about is that the cost is too high, and it cannot be quickly popularized and applied. It can only be used in a small number of large medical centers, and operators also need a lot of experience to use it in clinical applications.

[0005] Hemodialysis and filtration systems draw blood out of the body through radial artery drainage and other methods, and use specific methods to filter out certain components in the blood or add certain specific components to complete the patient's treatment plan.

[0006] The blood drainage volume of the hemodialysis or filtration system is small, and the roller pump system is prone to blood damage. Without an oxygenator, extracorporeal blood oxygenation cannot be completed, and it cannot be used to relieve pulmonary dyspnea symptoms. If the oxygenator is forcibly connected, the roller pump is more likely to cause blood damage at the same blood flow rate, and the effect of use is far worse than the low-damage centrifugal pump used in the present invention; and because the drainage volume is insufficient and the blood flow velocity is low, it leads to the growth of blood clots in the oxygenator, increasing the patient's life risk.

[0007] Therefore, the design of portability and simplified operation is the direction of future development, which is conducive to reducing the training time of operators, increasing the number of operators, facilitating the rapid popularization of equipment, facilitating the effective implementation of emergency work, or saving patients' lives in scenarios where large-scale use is required. Summary of the invention

[0008] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a blood oxygenation and circulation device.

[0009] The objective of the present invention is achieved through the following technical solutions:

[0010] A blood oxygenation and circulation device, comprising a boost module and an oxygenation module;

[0011] The oxygenation module comprises an oxygenator shell, an annular water film isolation plate is arranged inside the oxygenator shell, an annular air-water isolation plate is arranged inside the water film isolation plate, an annular air-blood isolation plate is arranged inside the air-water isolation plate, a central blood channel is formed inside the air-blood isolation plate, a pressure regulating area and a blood collecting area are formed between the air-blood isolation plate and the air-water isolation plate, an air-blood barrier is arranged between the pressure regulating area and the blood collecting area, a heat exchange area is formed between the air-water isolation plate and the water film isolation plate, an oxygenation area is formed between the water film isolation plate and the oxygenator shell, a plurality of penetrating blood circulation channels are arranged on both the water film isolation plate and the air-water isolation plate, an annular air collecting area is arranged between the oxygenator shell and the oxygenation area, the annular air collecting area is arranged near the blood inlet side, and the blood inlet is connected to the central blood channel;

[0012] The water film isolation plate, the air-water isolation plate and the air-blood isolation plate are all connected to the boost module.

[0013] Furthermore, the boost module includes a blood pump housing, a central axis coaxial with the central blood channel is arranged inside the blood pump housing, a plurality of impellers are arranged on the central axis, the impellers are arranged in the impeller area of ​​the blood pump, a yoke and a yoke seat are arranged between the blood pump housing and the impeller, the yoke is arranged between the yoke seat and the central axis, a protective shaft is arranged at the end of the central axis, and the protective shaft is arranged close to the central blood channel.

[0014] Furthermore, the blood pump housing includes a blood pump lower housing and a blood pump upper housing cooperating with the blood pump lower housing, the water film isolation plate, the air-water isolation plate and the air-blood isolation plate divide the blood pump upper housing into a blood flow channel inlet, a gas flow channel, a variable temperature liquid flow channel and a blood flow channel outlet, the blood flow channel inlet is connected to the lower side of the oxygenation zone through a blood flow channel, the gas flow channel is arranged on the lower side of the oxygenation zone, the variable temperature liquid flow channel is arranged on the lower side of the heat exchange zone, and the blood flow channel outlet is arranged between the blood collection zone and the blood pump impeller zone.

[0015] Furthermore, an annular blood collection chamber is formed between the upper shell of the blood pump, the oxygenation area and the oxygenator shell.

[0016] Furthermore, a blood outlet, a gas outlet and a variable temperature liquid inlet are provided on the upper shell of the blood pump, the blood outlet is connected to the blood collection area, the gas outlet is connected to the oxygenation area, and the variable temperature liquid inlet is connected to the heat exchange area.

[0017] Furthermore, a plurality of blood pumping flow channels for blood transfusion are arranged between the oxygenation area and the boosting module.

[0018] Furthermore, the blood flow channel includes a blood flow channel 1 for blood to enter the blood collection area from the heat exchange area, and also includes a blood flow channel 2 for blood to enter the heat exchange area from the oxygenation area.

[0019] Furthermore, the oxygenation module is also provided with a gas inlet, a variable temperature liquid outlet, an exhaust port 1 and an exhaust port 2. The gas inlet is connected to the annular gas collecting area and the oxygenation area, the variable temperature liquid outlet is connected to the heat exchange area, and the exhaust port 1 and the exhaust port 2 are connected to the oxygenation area and are symmetrically arranged.

[0020] Furthermore, the boost module and the oxygenation module are fixed via a fixing block.

[0021] Furthermore, a pressure control switch is provided on the top of the pressure regulating area.

[0022] The beneficial effects of the present invention are:

[0023] 1. The integrated pump-lung design is much smaller than the pump-lung structure (saving the space of one device), which saves the space occupied by the equipment, reduces the product pre-filling, removes the pipeline connection between the pump and the lung, and improves the efficiency of membrane lung use.

[0024] 2. The pump flow channel design is equipped with four outlets, which is conducive to increasing the flow rate and the operating speed. The pump impeller and center shaft design enable stable operation at low speed.

[0025] 3. The oxygenator flow channel design allows blood to diffuse from the circumference to the center, and the closed-loop flow method helps to improve oxygenation efficiency. The structural design allows the product to have a larger blood oxygenation area in the same volume of oxygenation area; the second pressure regulation and blood overflow gas discharge function avoid the overflow of micro bubbles in the blood caused by blood temperature changes, and also avoid overoxidation caused by excessive concentration of air and oxygen mixed gas, ensuring oxygenation stability and safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a schematic diagram of the external structure of the blood oxygenation and circulation device;

[0027] Figure 2 It is a schematic diagram of the top view of the internal structure of the boost module;

[0028] Figure 3 for Figure 2 AA cross-sectional structural diagram;

[0029] Figure 4 This is a schematic diagram of the main structure of the boost module;

[0030] Figure 5 It is a schematic diagram of the structure of the blood oxygenation circulation device viewed from above;

[0031] Figure 6 Schematic diagram of the top view of the oxygenation module;

[0032] Figure 7 for Figure 6 BB cross-sectional structure diagram;

[0033] Figure 8 for Figure 6 Schematic diagram of CC cross-section structure;

[0034] Fig. 9 This is a schematic diagram of the installation structure of the gas and blood barrier;

[0035] Fig.10 It is a schematic diagram of the flow direction of gas in the blood oxygenation flow transfer device;

[0036] Fig.11 It is a schematic diagram of the flow direction of the temperature-changing liquid in the blood oxygenation flow transfer device;

[0037] Fig.12 This is a schematic diagram of the flow of blood in a blood oxygenation and circulation device.

[0038] In the figure, 1-boosting module, 2-oxygenation module, 3-blood inlet, 4-blood outlet, 5-gas inlet, 6-gas outlet, 7-variable temperature liquid inlet, 8-variable temperature liquid outlet, 9-fixing block, 10-pressure control switch, 11-blood pump impeller area, 12-pump blood flow channel, 13-blood pump housing, 14-blood flow channel inlet, 15-gas flow channel, 16-variable temperature liquid flow channel, 17-blood flow channel outlet, 18-exhaust port 1, 19-exhaust port 2, 20-annular blood collection chamber, 111-impeller, 112-yoke, 113-central axis, 114-yoke seat, 115-protective axis, 116-blood pump upper shell, 117-blood pump lower shell, 201-oxygenator shell, 202-water film isolation plate, 203-gas-blood isolation plate, 204-gas-water isolation plate, 205-heat exchange area, 206-oxygenation area, 207-pressure regulating area, 208-annular gas collection area, 209-blood collection area, 210-blood flow channel one, 211-blood flow channel two, 212-central blood channel, 301-gas-blood barrier. DETAILED DESCRIPTION

[0039] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.

[0040] See also Figure 1-12, the present invention provides a technical solution:

[0041] The blood oxygenation circulation device comprises a booster module 1 and an oxygenation module 2. The oxygenation module 2 comprises an oxygenator housing 201, an annular water film isolation plate 202 is arranged inside the oxygenator housing 201, an annular air-water isolation plate 204 is arranged inside the water film isolation plate 202, an annular air-blood isolation plate 203 is arranged inside the air-water isolation plate 204, a central blood channel 212 is formed inside the air-blood isolation plate 203, a pressure regulating area 207 and a blood collection area 209 are formed between the air-blood isolation plate 203 and the air-water isolation plate 204, and a pressure regulating area 207 and a blood collection area 209 are arranged between the pressure regulating area 207 and the blood collection area 209. A gas-blood barrier 301 is provided, a heat exchange area 205 is formed between the gas-water isolation plate 204 and the water film isolation plate 202, an oxygenation area 206 is formed between the water film isolation plate 202 and the oxygenator housing 201, a plurality of blood circulation channels are provided on the water film isolation plate 202 and the gas-water isolation plate 204, an annular gas collection area 208 is provided between the oxygenator housing 201 and the oxygenation area 206, and the annular gas collection area 208 is provided near the blood inlet 3, and the blood inlet 3 is connected to the central blood channel 212. The water film isolation plate 202, the gas-water isolation plate 204 and the gas-blood isolation plate 203 are all connected to the boosting module 1.

[0042] The heat exchange area 205 is the area where the blood undergoes heat exchange. It is annular in shape, and the temperature-changing liquid flows from bottom to top in the temperature-changing liquid micro-pipeline, and the blood flows from the periphery to the inside and from top to bottom outside the pipeline to achieve heat exchange.

[0043] The oxygenation area 206 is an area where the blood is oxygenated. It is annular in shape, and the air-oxygen mixed gas flows from top to bottom in the oxygenation film channel, and the blood flows from the periphery to the inside and from bottom to top outside the pipeline to achieve oxygen exchange.

[0044] The annular gas collection area 208 has the first exhaust pressure regulation function. The pressure regulation area 207 cooperates with the blood collection area and the gas-blood barrier to achieve pressure regulation and the second exhaust function. The blood collection area 209 is the blood collection area before the blood flows out, providing the second pressure regulation and the second exhaust capability.

[0045] Blood circulation channel 210 is a blood flow channel for blood to enter the blood collection area from the heat exchange area. There are 4 channels in total, which are cross-symmetrical. A blocking cover can be set to close some channels. Blood circulation channel 1 211 is a blood flow channel for blood to enter the heat exchange area from the oxygenation area. There are 4 channels in total, which are cross-symmetrical. A blocking cover can be set to close some channels. There are 4 blood circulation channels 210 and 211, respectively, which reduce oxygenation resistance, form a specific angle with the entrance and exit, increase blood flow distance, and improve oxygenation effect.

[0046] The air-blood barrier 301 is a thin film layer made of blood-isolating but not air-isolating material, which provides exhaust capability for the blood collection area and protects the outflow pressure of blood at the same time.

[0047] The boost module 1 includes a blood pump housing 13, a central shaft 113 coaxial with the central blood channel 212 is arranged inside the blood pump housing 13, a plurality of impellers 111 are arranged on the central shaft 113, and the impellers 111 are arranged in the blood pump impeller area 11, a yoke 112 and a yoke seat 114 are arranged between the blood pump housing 13 and the impeller 111, the yoke 112 is arranged between the yoke seat 114 and the central shaft 113, and a protective shaft 115 is arranged at the end of the central shaft 113, and the protective shaft 115 is arranged on the side close to the central blood channel 212. The protective shaft 115 serves to protect the blood pump housing 13 and the impeller 111, and prevents the impeller 111 from being worn due to excessively high speed or the central shaft 113 from wearing the upper housing 116 of the blood pump, which may cause the boost module 1 to be unstable or fail in function. The central shaft 113 is used to fix and stabilize the impeller 111, so that the impeller is fixed in the central area of ​​the blood pump housing 13, there is no up and down floating, and damage to the blood pump housing 13 is avoided. When the central shaft 113 runs at a low speed, the stable impeller 111 will not shake left and right.

[0048] In some embodiments, the yoke 112 is fixed in the yoke seat 114, and a central shaft 113 is fixed in the center of the yoke seat 114. The central shaft 113 and the impeller 111 are integrally injection molded. By controlling the change of the external driving magnetic field, the yoke seat 114 is forced to rotate, and finally the impeller 111 is driven to rotate, thereby realizing the driving control function. The yoke seat 114 is provided with a slot for fixing the yoke 112, and 4-8 magnets and yokes 112 are distributed. The magnets are placed according to the magnetic field planning, and the driving magnetic field is formed in combination with the yoke 112 in the same position. In this device, 6 magnets and yokes 112 are designed.

[0049] The blood pump housing 13 includes a blood pump lower housing 117 and a blood pump upper housing 116 that cooperates with the blood pump lower housing 117. The water film isolation plate 202, the air-water isolation plate 204 and the air-blood isolation plate 203 divide the blood pump upper housing into a blood flow channel inlet 14, a gas flow channel 15, a variable temperature liquid flow channel 16 and a blood flow channel outlet 17. The blood flow channel inlet 14 is connected to the lower side of the oxygenation area 206 through the blood pump flow channel 12. The gas flow channel 15 is arranged on the lower side of the oxygenation area 206. The variable temperature liquid flow channel 16 is arranged on the lower side of the heat exchange area 205. The blood flow channel outlet 17 is arranged between the blood collection area 209 and the blood pump impeller area 11.

[0050] An annular blood collection chamber 20 is formed between the upper housing 116 of the blood pump, the oxygenation zone 206 and the oxygenator housing 201. The upper housing 116 of the blood pump is provided with a blood outlet 4, a gas outlet 6 and a temperature-changing liquid inlet 7. The blood outlet 4 is connected to the blood collection zone 209, the gas outlet 6 is connected to the oxygenation zone 206, and the temperature-changing liquid inlet 7 is connected to the heat exchange zone 205. The annular blood collection chamber 20 is preferably in a wavy annular configuration, which is beneficial to reducing blood damage. It can also be designed into other shapes to provide blood pressure collection conditions before oxygenation, which can reduce the shear force of blood after it leaves the pump and is also beneficial to the next step of oxygenation.

[0051] In some embodiments, a plurality of blood pumping circulation channels 12 for blood transfusion are provided between the oxygenation area 206 and the booster module 1. The blood pumping circulation channels 12 have four, that is, four blood outlets when the pump is in operation, and simultaneously transport blood to the upper oxygenation module 2. After the blood flows out of the pump, the shear stress applied to the cells by the blood pump is small, and the possibility of dead zones is low, which is conducive to blood protection. The annular blood collection bin is used to compress the blood to increase the pre-oxygenation pressure, and the blood circulation channels are used to reduce the difficulty of blood flow during the oxygenation process and reduce the oxygenation resistance.

[0052] In some embodiments, the blood flow channel includes a blood flow channel 1 210 for blood to enter the blood collection area 209 from the heat exchange area 205 , and also includes a blood flow channel 2 211 for blood to enter the heat exchange area 205 from the oxygenation area 206 .

[0053] In some embodiments, the oxygenation module 2 is further provided with a gas inlet 5, a variable temperature liquid outlet 8, an exhaust port 18 and an exhaust port 2 19. The gas inlet 5 is connected to the annular gas collection area 208 and the oxygenation area 206, the variable temperature liquid outlet 8 is connected to the heat exchange area 205, and the exhaust port 1 18 and the exhaust port 2 19 are connected to the oxygenation area 206 and are arranged symmetrically. The exhaust port 1 18 and the exhaust port 2 19 are used for exhaust during the priming process and are used when the oxygenation channel exhausts the gas overflowing from the blood during the operation. The two exhaust ports are symmetrically arranged and located at the upper part of the overall oxygenation channel.

[0054] In some embodiments, the boost module 1 and the oxygenation module 2 are fixed by a fixing block 9. The blood pump housing 13 is composed of a blood pump lower housing 117 with a special structure and a blood pump upper housing 116. The blood pump upper housing 116 is designed to be combined with the oxygenation module 1 to form a fixed structure, that is, a fixing block 9, and cooperates with the oxygenator housing 201 to realize the heat exchange area 205 and the oxygenation area 206. The fixing block is fixed by mortise and tenon joints and glued. The blood pump lower housing 117 is provided with the entrance and exit of each channel.

[0055] In some embodiments, a pressure control switch 10 is disposed on the top of the pressure regulating area 207 to set the pressure in the pressure regulating area 207 and then adjust the pressure in the blood collection area 209 .

[0056] In some embodiments, the blood inlet 3 and the blood outlet 4 are at an angle of approximately 105° in the vertical plane, the gas inlet 5 and the gas outlet 6 are at an angle of approximately 15° in the vertical plane, and the temperature-changing liquid inlet 7 and the temperature-changing liquid outlet 8 are at an angle of approximately 90° in the horizontal plane.

[0057] Flow process:

[0058] (1) Gas flow process: Fig.10 As shown, the gas enters from the gas inlet 5, flows to the oxygenation area 206, and then is discharged from the gas outlet 6 below after being fully oxygenated with the blood.

[0059] (2) Variable temperature liquid flow process: Fig.11 As shown, the temperature-changing liquid enters from the temperature-changing liquid inlet 7, flows into the heat exchange area 205, and then flows out from the temperature-changing liquid outlet 8 above after completing heat exchange with the blood.

[0060] (3) Blood flow process: Fig.12 As shown, blood enters from the upper blood inlet 3, enters the boosting module 1 along the central blood channel 212, is accelerated by the impeller 111 in the boosting module 1, and enters the annular blood collecting chamber 20 along the blood pumping flow channel 12 around the pump body. After the blood is slightly collected in the annular blood collecting chamber 20, it enters the oxygenation zone 206 and flows upward to complete oxygenation. In the upper part of the oxygenation zone 206, the blood enters the heat exchange zone 205 through the blood flow channel 2 211. The blood flows from top to bottom in the heat exchange zone 205. In the lower part of the heat exchange zone 205, the blood flows through the blood flow channel 1 210 into the central blood collection zone 209. In the blood collection zone 209, the overflow gas of the blood is discharged through the gas-blood barrier 301, and finally the blood flows out through the blood outlet 4.

[0061] The above is only a preferred embodiment of the present invention. It should be understood that the present invention is not limited to the form disclosed herein, and should not be regarded as excluding other embodiments, but can be used in various other combinations, modifications and environments, and can be modified within the scope of the concept described herein through the above teachings or the technology or knowledge of the relevant field. The changes and modifications made by those skilled in the art shall not deviate from the spirit and scope of the present invention, and shall be within the scope of protection of the claims attached to the present invention.

Claims

1. A blood oxygenation and circulation device, characterized in that: It comprises a boost module (1) and an oxygenation module (2); The oxygenation module (2) comprises an oxygenator housing (201), an annular water film isolation plate (202) is arranged inside the oxygenator housing (201), an annular air-water isolation plate (204) is arranged inside the water film isolation plate (202), an annular air-blood isolation plate (203) is arranged inside the air-water isolation plate (204), a central blood channel (212) is formed inside the air-blood isolation plate (203), a pressure regulating area (207) and a blood collection area (209) are formed between the air-blood isolation plate (203) and the air-water isolation plate (204), and an air-blood barrier (301) is arranged between the pressure regulating area (207) and the blood collection area (209). ), a heat exchange area (205) is formed between the air-water isolation plate (204) and the water film isolation plate (202), and the heat exchange area (205) is in a circular ring shape; an oxygenation area (206) is formed between the water film isolation plate (202) and the oxygenator housing (201), and a plurality of blood circulation channels are provided on the water film isolation plate (202) and the air-water isolation plate (204); an annular gas collection area (208) is provided between the oxygenator housing (201) and the oxygenation area (206), and the annular gas collection area (208) is provided near the blood inlet (3), and the blood inlet (3) is connected to the central blood channel (212); The water film isolation plate (202), the air-water isolation plate (204) and the air-blood isolation plate (203) are all connected to the boost module (1); The boost module (1) comprises a blood pump housing (13), wherein a central axis (113) coaxial with the central blood channel (212) is arranged inside the blood pump housing (13), a plurality of impellers (111) are arranged on the central axis (113), and the impellers (111) are arranged in a blood pump impeller area (11), a yoke (112) and a yoke seat (114) are arranged between the blood pump housing (13) and the impeller (111), and the yoke (112) is arranged between the yoke seat (114) and the central axis (113), and a protective shaft (115) is arranged at the end of the central axis (113), and the protective shaft (115) is arranged on a side close to the central blood channel (212).

2. The blood oxygenation and circulation device according to claim 1, characterized in that: The blood pump housing (13) comprises a blood pump lower housing (117) and a blood pump upper housing (116) matched with the blood pump lower housing (117); the water film isolation plate (202), the air-water isolation plate (204) and the air-blood isolation plate (203) divide the blood pump upper housing into a blood flow channel inlet (14), a gas flow channel (15), a variable temperature liquid flow channel (16) and a blood flow channel outlet (17); the blood flow channel inlet (14) is connected to the lower side of the oxygenation zone (206) through a blood pump circulation channel (12); the gas flow channel (15) is arranged on the lower side of the oxygenation zone (206); the variable temperature liquid flow channel (16) is arranged on the lower side of the heat exchange zone (205); and the blood flow channel outlet (17) is arranged between the blood collection zone (209) and the blood pump impeller zone (11).

3. The blood oxygenation and circulation device according to claim 2, characterized in that: An annular blood collection chamber (20) is formed between the blood pump upper housing (116), the oxygenation area (206) and the oxygenator housing (201).

4. The blood oxygenation and circulation device according to claim 2, characterized in that: The upper housing (116) of the blood pump is provided with a blood outlet (4), a gas outlet (6) and a temperature-variable liquid inlet (7); the blood outlet (4) is connected to the blood collection area (209), the gas outlet (6) is connected to the oxygenation area (206), and the temperature-variable liquid inlet (7) is connected to the heat exchange area (205).

5. The blood oxygenation and circulation device according to claim 2, characterized in that: A plurality of blood pumping channels (12) for blood transfusion are arranged between the oxygenation area (206) and the pressure boosting module (1).

6. The blood oxygenation and circulation device according to claim 1, characterized in that: The blood flow channel includes a blood flow channel 1 (210) for blood to enter the blood collection area (209) from the heat exchange area (205), and also includes a blood flow channel 2 (211) for blood to enter the heat exchange area (205) from the oxygenation area (206).

7. The blood oxygenation and circulation device according to claim 1, characterized in that: The oxygenation module (2) is further provided with a gas inlet (5), a variable temperature liquid outlet (8), an exhaust port 1 (18) and an exhaust port 2 (19); the gas inlet (5) is connected to the annular gas collecting area (208) and the oxygenation area (206); the variable temperature liquid outlet (8) is connected to the heat exchange area (205); the exhaust port 1 (18) and the exhaust port 2 (19) are connected to the oxygenation area (206) and are symmetrically arranged.

8. The blood oxygenation and circulation device according to claim 1, characterized in that: The boost module (1) and the oxygenation module (2) are fixed via a fixing block (9).

9. The blood oxygenation and circulation device according to claim 1, characterized in that: A pressure control switch (10) is provided at the top of the pressure adjustment area (207).

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