Implantable controllable pressure microballoon small animal spinal nerve compression device

Abstract

The application discloses an implantable controllable pressure microballoon small animal spinal nerve compression device, which comprises a liquid-filled balloon, a pressing plate, an extrusion screw rod, a nut sleeve and a balloon catheter arranged in a subcutaneous blocking fabric; the pressing plate is arranged above the liquid-filled balloon; the extrusion screw rod penetrates through the skin blocking fabric from outside the skin and is arranged above the pressing plate; the nut sleeve is arranged in the skin blocking fabric and the extrusion screw rod is sleeved in the nut sleeve; the balloon catheter is communicated with the liquid-filled balloon through a liquid guide pipe; and a pressure gauge is further arranged at a liquid inlet of the balloon catheter. The device can be used for simulating spinal nerve compression injury in animal experiments, is convenient to operate, controllable in force, can detect pressure and improves the accuracy of experiments.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical animal experiment devices, in particular to an implantable controllable pressure microballoon small animal spinal nerve compression device. BACKGROUND

[0002] Spinal cord compression nerves, including nerve roots and spinal cord, compression nerve roots appear root symptoms, such as compression of the cervical nerve root, may cause hand numbness, compression of the thoracic nerve root can cause intercostal pain, and even because the spinal column is in the back, it can cause anterior chest pain and radiating pain. If the lumbar nerve root is compressed, it can cause symptoms similar to lumbar disc herniation, which can cause radiating pain in the lower extremities. There are compression of the bone nerve group, such as the upper lumbar nerve root, which can manifest as pain in the front of the thigh. If the sciatic nerve group is compressed, it is the lower nerve, such as the L4-L5-S1 nerve root, which will cause sciatica.

[0003] The pathophysiological mechanism after spinal cord injury is complex, and the current treatment effect is not ideal; it is crucial to study the mechanism and treatment method of spinal cord injury and establish a spinal nerve injury model; in neurological experimental research, the method of nerve injury is usually used to establish animal experimental nerve injury, but when conducting animal experiments, small animals usually use live experiments, whose activities are uncontrollable, so the external device will be affected by the activities and affect the accuracy of the experiment, and it is not convenient to operate; in addition, the existing device for simulating nerve compression injury has low precision in pressure control and experiment precision; therefore, an implantable controllable pressure microballoon small animal spinal nerve compression device is needed to improve the accuracy of the experiment. SUMMARY

[0004] The purpose of the present application is to provide an implantable controllable pressure microballoon small animal spinal nerve compression device, which can simulate spinal nerve compression injury, is convenient to operate, has controllable pressure, high precision, and can greatly improve the accuracy of the experiment.

[0005] To achieve the above-mentioned purpose, the present application provides the following technical scheme:

[0006] An implantable controllable pressure microballoon small animal spinal nerve compression device, comprising a liquid-filled balloon, a pressing plate, an extrusion screw, a nut sleeve, and a balloon catheter; the liquid-filled balloon is arranged in the subcutaneous tissue of an animal, the pressing plate is arranged above the liquid-filled balloon, the extrusion screw penetrates the skin of the animal from the outside and abuts against the upper side of the pressing plate, the nut sleeve is arranged in the skin of the animal and the extrusion screw is sleeved in the nut sleeve, and the balloon catheter is in communication with the liquid-filled balloon through a liquid guide tube.

[0007] Specific, the lower of the liquid filled balloon is also provided with a mounting block, the mounting block is fixed with the skin, the mounting block is provided with a containing groove, the liquid filled balloon is arranged in the containing groove.

[0008] Specific, the end of the extrusion screw placed outside the skin is provided with an extrusion handle.

[0009] Specific, the end of the liquid guide tube close to the liquid filled balloon is provided with a fixed knot, the fixed knot is fixed to the skin.

[0010] Specific, the balloon catheter includes an outer lumen tube, an inner lumen tube and an expansion balloon, the inner lumen tube is through the outer lumen tube, the inner lumen tube is a hollow tube with two open ends, the expansion balloon is wrapped outside the distal end of the inner lumen tube and is communicated with the distal end of the outer lumen tube to the chamber thereof, the proximal end of the outer lumen tube is provided with a perfusion hole, the liquid guide tube is communicated with the perfusion hole for guiding liquid, and the pressure gauge is arranged at the proximal end of the outer lumen tube.

[0011] Specific, the expansion balloon is made of high-toughness resin material.

[0012] Specific, the distal end of the expansion balloon is provided with a sharp end, the sharp end is provided with a through hole and is communicated with the inner lumen tube.

[0013] The use method of the implantable controllable pressure microballoon small animal spinal nerve compression device, comprising the following steps:

[0014] Step one: after the small animal is anesthetized, it is placed on the operating table in a prone position, the skin on one side of the spine is cut after conventional disinfection, the incision is separated after hemostasis and the liquid filled balloon is placed, and a pressing plate is arranged above the liquid filled balloon;

[0015] Step two: install the nut sleeve at the skin incision, rotate the extrusion screw into the nut sleeve and the bottom end is abutted above the pressing plate;

[0016] Step three: connect the liquid filled balloon to the liquid guide tube, the other end of the liquid guide tube is through the subcutaneous tissue and connected to the balloon catheter;

[0017] Step four: guide the balloon catheter with the expansion balloon to the target spinal nerve part as the front end through the guide wire;

[0018] Step five: rotate the extrusion screw to push the pressing plate downward, and then extrude the liquid filled balloon, so that the liquid in the liquid filled balloon enters the balloon catheter, the expansion balloon of the balloon catheter is deformed and inflated, the expansion balloon contacts and compresses the target nerve, and the nerve compression symptom can be simulated.

[0019] Compared with the prior art, the beneficial effects of the present application are that the liquid-filled balloon, pressing plate, extrusion screw, nut sleeve and other injection pressure components of the present application are arranged on the experimental animal, facilitating injection pressure operation and improving the controllability of the experiment, the end of the balloon catheter with the expansion balloon is inserted into the spinal canal through the communication of the liquid-filled balloon and the balloon catheter, so that the spinal nerve compression simulation experiment can be carried out, and the nerve compression pressure can be adjusted through the cooperation of the extrusion screw and the nut sleeve, and the pressure can be detected through the pressure gauge on the balloon catheter, improving the accuracy of the experiment. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 It is a structural schematic diagram of the present application.

[0021] Figure 2 It is a distal end face view of the balloon catheter of the present application.

[0022] In the figure: 1, liquid-filled balloon; 2, pressing plate; 3, extrusion screw; 4, nut sleeve; 5, balloon catheter; 6, liquid guide tube; 7, pressure gauge; 8, mounting block; 9, fixed knot; 31, extrusion handle; 51, outer lumen tube; 52, inner lumen tube; 53, expansion balloon; 54, sharp end; 511, perfusion hole; 81, accommodating groove. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the present application will be described clearly and completely below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0024] The terms "upper", "distal", "proximal" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, which is only for the convenience of description and simplification of description, and is not intended to indicate or imply a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0025] Please refer to Figures 1-2 The present application provides a technical solution: an implantable controllable pressure microballoon small animal spinal nerve compression device, comprising a liquid-filled balloon 1, a pressing plate 2, an extrusion screw 3, a nut sleeve 4 and a balloon catheter 5, the liquid-filled balloon 1, the pressing plate 2, the extrusion screw 3, the nut sleeve 4 and other injection pressure components are arranged on the experimental small animal, which is convenient to operate and controllable, and will not affect the accuracy of the injection pressure components due to the movement of the small animal, reducing the external disturbance to the experiment.

[0026] The liquid-filled balloon 1 is in communication with the balloon catheter 5, and the balloon catheter 5 is inserted into the spinal canal of a small animal through a guide wire, so that the expansion balloon 53 on the balloon catheter 5 is inflated, and the inflated expansion balloon 53 contacts and presses the target nerve, so as to simulate the spinal nerve compression injury.

[0027] Specifically, the liquid-filled balloon 1 is arranged in the subcutaneous tissue of the animal, the pressing plate 2 is arranged above the liquid-filled balloon 1, the extrusion screw rod 3 penetrates the skin of the animal from the outside of the skin and abuts against the upper side of the pressing plate 2, the nut sleeve 4 is arranged in the skin of the animal and the extrusion screw rod 3 is sleeved in the nut sleeve 4, the extrusion screw rod 3 is rotated downward to press the pressing plate 2 and then extrude the liquid-filled balloon 1, so that the liquid in the liquid-filled balloon 1 is extruded into the balloon catheter 5, and then the expansion balloon 53 on the balloon catheter 5 is inflated to contact and press the spinal nerve; in order to facilitate the rotation of the extrusion screw rod 3, the end of the extrusion screw rod 3 arranged outside the skin of the animal is provided with an extrusion handle 31, so as to facilitate the rotation and pressing of the extrusion screw rod 3. The lower side of the liquid-filled balloon 1 is also provided with a mounting block 8, the mounting block 8 is fixed to the subcutaneous tissue, the mounting block 8 is provided with a receiving groove 81, and the liquid-filled balloon 1 is arranged in the receiving groove 81, so as to facilitate the pressing and liquid extrusion operation.

[0028] The balloon catheter 5 is in communication with the liquid-filled balloon 1 through the liquid guide tube 6, one end of the liquid guide tube 6 penetrates the mounting block 8 and is in communication with the liquid-filled balloon 1 in the receiving groove 81, and the other end of the liquid guide tube 6 penetrates the subcutaneous tissue and is in communication with the balloon catheter 5; in order to prevent the liquid-filled balloon 1 and the mounting block 8 from being pulled out, the end of the liquid guide tube 6 close to the liquid-filled balloon 1 is provided with a fixed knot 9, and the fixed knot 9 is fixed to the subcutaneous tissue. In order to monitor the liquid inlet pressure of the balloon catheter 5, a pressure gauge 7 is arranged at the liquid inlet of the balloon catheter, so as to monitor the liquid inlet pressure and then adjust the extrusion pressure of the liquid-filled balloon 1.

[0029] The balloon catheter 5 specifically includes an outer lumen tube 51, an inner lumen tube 52 and an expansion balloon 53; the inner lumen tube 52 penetrates the outer lumen tube 51, the inner lumen tube 52 is a hollow tube with two open ends, which can be used to penetrate a guide wire to guide the balloon catheter 5 to the required position; the expansion balloon 53 is wrapped around the outer part of the distal end of the inner lumen tube 52 and is in communication with the chamber of the distal end of the outer lumen tube 51, and the proximal end of the outer lumen tube 51 is provided with a perfusion hole 511, such as Figure 2As shown, the liquid guide tube 6 is connected to the perfusion hole 511 to guide the liquid. The liquid in the liquid-filled balloon 1 enters the chamber of the outer lumen 51 through the liquid guide tube 6 and then flows into the expansion balloon 53, causing it to deform and expand, contacting and compressing the target nerve. The expansion balloon 53 can be made of a high-toughness resin material, which has high toughness, allowing it to be made thinner and withstand higher pressures. In this embodiment, the pressure gauge 7 can be located at the proximal end of the outer lumen 51 to detect the pressure of the liquid entering the outer lumen 51. The internal pressure of the expansion balloon 53 can be adjusted based on the value of the pressure gauge 7. The distal end of the expansion balloon 53 can also be provided with a tip 54. Specifically, the tip 54 can be fixedly connected to the distal end of the expansion balloon 53 by welding. The tip 54 has a through hole and is connected to the inner lumen 52. The guidewire can pass through the inner lumen 52 and exit at the tip of the tip 54. The tip facilitates passage through blood vessels during surgery. In addition, the puncture operation of the balloon catheter 5 is a conventional surgical operation, and the surgical process will not be described in detail here.

[0030] It should be noted that the above device can be fixed to the skin and flesh of small animals by surgical suture or other experimental fixation methods. During the surgery, it is necessary to pay attention to aseptic conditions and routinely use antibiotics for infection after the surgery.

[0031] The method for using the above-mentioned implantable pressure-controlled microballoon small animal spinal nerve compression device comprises the following steps:

[0032] Step 1: After anesthesia, the small animal is placed prone on the operating table. After routine disinfection, the skin on one side of the spine is incised. After hemostasis, the incision is separated and a fluid-filled balloon 1 is placed. A pressure plate 2 is installed above the fluid-filled balloon 1.

[0033] Step 2: Install the nut sleeve 4 at the skin incision, screw the extrusion screw 3 into the nut sleeve 4 and make the bottom end touch the top of the pressing plate 2;

[0034] Step 3: The liquid-filled balloon 1 is connected to the liquid catheter 6, and the other end of the liquid catheter 6 penetrates the subcutaneous tissue and is connected to the balloon catheter 5;

[0035] Step 4: Using the guidewire, the balloon catheter 5 is guided with the end of the balloon 53 as the leading end into the target spinal nerve area;

[0036] Step 5: Rotate the extrusion screw 3 to push the pressing plate 2 downward, thereby squeezing the liquid-filled balloon 1, causing the stored liquid inside to enter the balloon catheter 5, causing the expansion balloon 53 of the balloon catheter 5 to deform and expand, so that the expansion balloon 53 contacts and compresses the target nerve, thereby simulating nerve compression symptoms.

[0037] The liquid-filled balloon 1, the pressing plate 2, the extrusion screw 3, the nut sleeve 4 and other injection pressure components are arranged on the experimental animal, so that the injection pressure operation is facilitated, the operation controllability of the experiment is improved, in the experimental monitoring process, the injection pressure components are not dragged due to the movement of the animal, and the accuracy of the experimental results is not affected, one end of the balloon catheter 5 with the expanding balloon 53 is inserted into the spinal canal through the communication between the liquid-filled balloon 1 and the balloon catheter 5, and then the spinal nerve compression simulation experiment can be carried out, the accuracy of the simulated damage position is high, the injection pressure degree can be detected and controlled, the operation is convenient, the controllability of the whole experiment is good, and the accuracy of the experiment is greatly improved.

[0038] Although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art can modify the technical solutions recorded in the foregoing embodiments or make equivalent replacements to some technical features, and any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. An implantable pressure-controlled microballoon spinal nerve compression device for small animals, characterized by: It comprises a liquid-filled balloon (1), a pressure plate (2), an extrusion screw (3), a nut sleeve (4) and a balloon catheter (5); the liquid-filled balloon (1) is arranged in the subcutaneous resistance fabric of an animal, the pressure plate (2) is arranged above the liquid-filled balloon (1), the extrusion screw (3) passes through the animal skin resistance fabric from the outside of the animal skin and abuts against the top of the pressure plate (2), the nut sleeve (4) is arranged in the animal skin resistance fabric and the extrusion screw (3) is sleeved in the nut sleeve (4), the balloon catheter (5) is connected to the liquid-filled balloon (1) through a liquid guide tube (6) for liquid conduction; a pressure gauge (7) is also provided at the liquid inlet of the balloon catheter (5); The balloon catheter (5) comprises an outer lumen tube (51), an inner lumen tube (52) and an expansion balloon (53); the inner lumen tube (52) passes through the outer lumen tube (51), and the inner lumen tube (52) is a hollow tube with two ends open; the expansion balloon (53) is wrapped around the distal end of the inner lumen tube (52) and is connected to the distal end of the outer lumen tube (51) to its chamber; the proximal end of the outer lumen tube (51) is provided with a perfusion hole (511), the liquid guide tube (6) is connected to the perfusion hole (511) for liquid conduction, and the pressure gauge (7) is provided at the proximal end of the outer lumen tube (51); A mounting block (8) is further provided below the liquid-filled balloon (1), the mounting block (8) being fixed to the subcutaneous resistance fabric, the mounting block (8) being provided with a receiving groove (81), and the liquid-filled balloon (1) being arranged in the receiving groove (81).

2. The implantable pressure-controlled microballoon spinal nerve compression device for small animals according to claim 1, characterized in that: The end of the extrusion screw (3) outside the skin is provided with an extrusion handle (31).

3. The implantable pressure-controlled microballoon spinal nerve compression device for small animals according to claim 1, characterized in that: A fixing knot (9) is provided at one end of the liquid-filled balloon (1) near the liquid-filled balloon (6), and the fixing knot (9) is fixed to the subcutaneous tissue.

4. The implantable pressure-controlled microballoon small animal spinal nerve compression device according to claim 1, characterized in that: The expansion balloon (53) is made of high-toughness resin.

5. The implantable pressure-controlled microballoon small animal spinal nerve compression device according to claim 1, characterized in that: The distal end of the expansion balloon (53) is provided with a tip (54), and the tip (54) is provided with a through hole and communicates with the inner cavity tube (52).

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