A system and method for formulating an acoustic stimulation nerve regulation treatment plan

Abstract

The present invention discloses a system and method for formulating an acoustic stimulation neuromodulation treatment plan, including: a signal input and analysis unit for auditory and / or non-auditory detection, an acoustic stimulation plan formulation and storage unit, and an acoustic stimulation plan implementation unit. Through the above-mentioned method, the system and method for formulating an acoustic stimulation neuromodulation treatment plan of the present invention can accurately formulate and implement a multi-course neuromodulation treatment rehabilitation plan that combines the physiological and psychological parts of a large category of chronic diseases such as refractory neurological dysfunction according to personalized test results, regularly track multiple treatment effects, objectively evaluate and predict development, qualitatively and quantitatively regulate and optimize the treatment effect of subsequent treatment plans, predict changes in neurological function status, and formulate and implement full-cycle management plans for various neurological dysfunction chronic diseases.

Description

Technical Field

[0001] The present invention relates to the field of diagnosis and treatment systems, and in particular to a system and method for formulating an acoustic stimulation nerve regulation treatment plan. Background Art

[0002] Neurological dysfunction diseases include but are not limited to tinnitus, sleep disorders, anxiety, depression, vertigo, autism, epilepsy, Parkinson's disease (ADHD), Alzheimer's disease (dementia), phonophobia, stuffy ears, migraine, and neural fatigue. These neurological dysfunctions involve, to varying degrees, dysfunction of the central deep brain and multiple brain functional areas and cerebral cortex functions and cross-effects of dynamic neural networks, which are reflected in objective physiological pathology and subjective psychological emotions. Various neurological dysfunctions show specific differences in lesions, pathogenesis, and cross-effects of brain functional areas. Neurological dysfunction diseases are the diseases with the highest incidence and the heaviest medical insurance burden in an aging society, and their pathogenesis is unclear, and there is a lack of special drugs and means. Almost every elderly person suffers from at least one neurological dysfunction disease. Neurological dysfunction is essentially a functional disorder in the transmission and filtering of electrophysiological signals by the nervous system, which belongs to the category of biophysics, and physical intervention treatment methods are more direct and suitable. Neuroregulatory therapy is an active physical intervention therapy, the core of which is what to adjust and how to control in order to achieve the best effect of quantitative treatment.

[0003] At present, there are still many shortcomings or weaknesses in the diagnosis and treatment of traditional neurological dysfunction diseases, such as: it is impossible to combine "objective physiology" and "subjective psychology" for precise treatment and comprehensive treatment, and it is impossible to implement differentiated, adjustable and controllable neuromodulation treatment for different brain functional areas and cerebral cortex, and the technical service efficiency is low, difficult to standardize and inconvenient for large-scale promotion. Therefore, people need a method for acoustic stimulation non-invasive neuromodulation precision treatment system based on neuroelectrophysiological principles that is generally applicable to the full-cycle management of multi-course treatment and rehabilitation of various neurological dysfunction chronic diseases, easy to implement clinical operations, and based on the principle of neuroelectrophysiology; this treatment system is based on personalized brain activity fluctuation signals expressed by various different physical quantities of various subjective and / or objective auditory and / or non-auditory neural activity detection devices, and has achieved a breakthrough from auditory detection to non-auditory detection, more comprehensively reflecting the physiological and psychological interactive cycle effects of neurological dysfunction, taking into account the commonalities of various neurological dysfunction diseases, while not losing sufficient flexibility to take into account the individual characteristics of various refractory neurological dysfunction diseases, as well as the different clinical characteristics and precision treatment requirements of the two ears. Summary of the invention

[0004] In order to solve the above technical problems, a technical solution adopted by the present invention is:

[0005] A system for formulating an acoustic stimulation neuromodulation treatment plan is provided, which includes: a neurological dysfunction detection signal input interface unit, a signal preprocessing unit, an acoustic stimulation plan formulation and storage unit, and an acoustic stimulation plan implementation unit. The fluctuating signal detected by human hearing and / or non-hearing and expressing brain activity in a variety of different physical quantities is input into the signal preprocessing unit through a brain-computer interface and the signal input interface unit to perform neuroelectrophysiological signal typing and conversion analysis on the signal. The acoustic stimulation plan formulation and storage unit formulates acoustic stimulation treatment plans corresponding to the two ear sides according to the processing information output by the signal preprocessing unit, so as to perform comprehensive physical intervention acoustic stimulation non-invasive neuromodulation precision treatment combining physiology and psychology. The acoustic stimulation plan implementation unit inputs the acoustic stimulation signal into the ear canal and converts it into a stimulation electrical signal through the cochlea, and enters the brain center through the auditory pathway to perform electrical stimulation neuromodulation on the cranial nervous system, thereby realizing neuromodulation precision treatment for various refractory neurological dysfunction diseases, and carrying out multi-course personalized treatment and rehabilitation full-cycle management of chronic neurological diseases.

[0006] A method for formulating an acoustic stimulation neuromodulation treatment plan, the steps of which include: inputting human auditory psychoacoustic detection signals and human non-auditory nerve biofeedback detection signals through a brain-computer interface, performing signal typing and conversion analysis on different auditory and / or non-auditory detection fluctuation signals on two ear sides expressed in different physical quantities, so as to decompose the signals into multiple signal components on different ear sides suitable for signal modulation processing, and extract signal characteristic parameters; inputting the signal components and characteristic parameters of each ear side into multiple single signal processing channels respectively, using a multi-channel multi-modal acoustic modulation signal processing algorithm, first simultaneously performing acoustic signal modulation processing on each signal processing channel, and then superimposing the acoustic modulation signals output by each channel And / or compound, combined with the diagnostic information of neurological dysfunction diseases to perform signal synthesis and signal modulation parameter optimization, and for different types of neurological dysfunction chronic diseases, output or compound into one or more multi-channel and multi-modal personalized acoustic stimulation non-invasive neuromodulation treatment plans for each ear; the personalized non-invasive neuromodulation treatment plan is implemented by inputting the auditory nerve channel through the left and / or right ear headphones respectively, and at the same time, a comprehensive physical intervention non-invasive neuromodulation acoustic stimulation precision treatment combining physiology and psychology is carried out to achieve multi-course personalized treatment and rehabilitation full-cycle management of neurological chronic diseases, among which the diagnostic information of neurological dysfunction diseases includes but is not limited to hearing threshold information, sleep information, anxiety information, and depression information.

[0007] In a preferred embodiment of the present invention, when obtaining the auditory detection signals of the two ear sides of the human body, the subjective detection signals and / or objective detection signals of the auditory nerves on each ear side of the human body are respectively input into the signal preprocessing unit through the brain-computer interface to perform signal typing and conversion analysis; the subjective detection includes but is not limited to the hearing threshold in the living noise environment, and the ultra-high frequency pure tone hearing detection extending from the conventional hearing frequency range of 1Hz to 8KHz to above 10KHz; the semi-objective and semi-subjective detection includes but is not limited to multi-channel multi-modal psychoacoustic tinnitus sound matching or restoration detection for complex tinnitus sound restoration, and the signal components of each channel are respectively expressed in simple sound elements, sound intensity, frequency range and / or melody, and the simple sound elements are not limited to pure tone, pulse, noise; the objective detection includes but is not limited to auditory brainstem evoked potential ABR detection and / or auditory multi-frequency steady-state evoked potential ASSR detection for auditory brainstem potential wave changes, event-related evoked potential ERP detection for detecting cognitive behavioral psychological activities and psychological reaction functions, and endogenous event-related evoked potential P300 detection.

[0008] In a preferred embodiment of the present invention, when acquiring non-auditory detection signals of the human body, the non-auditory detection signals obtained by non-auditory objective detection are input into a signal preprocessing unit through a brain-computer interface to perform signal typing and conversion analysis; the non-auditory detection signals of the human body include but are not limited to detection signals characterizing the electrophysiological activity of each brain functional area, the interaction of multiple brain functional areas, the dynamic changes of EEG signals, the properties of the neural network and the energy changes or differences, and the non-auditory objective detection methods include but are not limited to EEG signal detection and EEG-based event-related evoked potential ERP detection.

[0009] In a preferred embodiment of the present invention, the steps of performing signal typing and conversion analysis on human auditory and / or non-auditory detection signals include: selecting auditory detection signal waveforms and non-auditory detection signal waveforms; obtaining a fluctuation signal containing amplitude and frequency parameters, which reflects different physical quantities of electrophysiological activity of brain regions and interactions between multiple brain regions, through mathematical transformation and analytical processing of signal waves; when a complex wave signal has multiple frequency points or multiple peak and trough segments, the complex wave signal is decomposed into multiple signal components located in different frequency bands or with different wave characteristics, and the signal components are analyzed separately to extract signal characteristic parameters; wherein the mathematical transformation and analytical processing of the signal wave include but are not limited to fast Fourier transform FFT analysis of the signal in the time domain and frequency domain, wavelet transform WT time-frequency analysis, power spectral density analysis of brain wave signals and neural network attribute analysis, and the signal characteristic parameters are but are not limited to the signal waveform, amplitude A corresponding to each signal component m , frequency f m .

[0010] In a preferred embodiment of the present invention, when performing typing and conversion analysis on the subjective and / or objective detection signals reflecting the physiological and psychological parts of neurological dysfunction diseases, the complex waveforms that express the dynamic changes of neurophysiological activities and cognitive psychological activities separately and their interactions comprehensively are further typed and analyzed. The further typing analysis includes but is not limited to waveform mutation analysis, signal curve mutation cut point analysis, and specificity division analysis, so as to further adjust and optimize the signal component characteristic parameters.

[0011] In a preferred embodiment of the present invention, based on the typing and conversion analysis results of the human neuroelectrophysiological detection signal, combined with clinical subjective diagnostic information including but not limited to clinical characteristic information on sleep, anxiety, depression, and sound sensitivity and their mental and psychological subjective scale evaluation information, the characteristic parameters of the signal components are further adjusted and optimized.

[0012] In a preferred embodiment of the present invention, when the signal components of each signal channel are subjected to signal modulation processing respectively: firstly, the modulation wave trigonometric function is selected and the carrier trigonometric function is set, and the signal components are subjected to trigonometric function modulation processing, and the trigonometric function modulation processing includes but is not limited to sinusoidal wave amplitude modulation SAM, sinusoidal wave frequency modulation SFM, and sinusoidal wave amplitude-frequency mixed modulation SAFM; then, the unilateral or bilateral modulated sound signal of each channel is output to perform subsequent multi-channel multi-modal acoustic stimulation scheme synthesis; wherein, the parameters of the modulation wave trigonometric function are derived from the characteristic parameter values ​​reflecting the neural electrical activity signal components in each channel, and the characteristic parameter values ​​of the signal components include but are not limited to the main frequency point or the sub-frequency band frequency value f m And the hearing threshold amplitude change value A set not to exceed 20dB m , the amplitude value A of the carrier trigonometric function is obtained according to the preset amplitude modulation coefficient and frequency modulation coefficient based on the modulation wave ratio. c and frequency value f c , where the amplitude modulation coefficient is less than 1.0 and the frequency modulation coefficient ranges from 0.1% to 10%.

[0013] In a preferred embodiment of the present invention, when formulating a personalized acoustic stimulation treatment plan, the modulated acoustic signals output by each channel are directly superimposed and / or compounded according to the pre-set contribution weights of each channel to form a multi-channel multi-modal composite modulated acoustic signal; the composite modulated acoustic signals on the two ear sides are further subjected to background sound superposition and signal waveform control processing, and the processed control amplitude is superimposed with the hearing threshold of the main frequency point corresponding to the wave signal detected or transformed on the corresponding ear side of the human body, and after the left and right ears are balanced and adjusted in volume, a personalized multi-channel multi-modal acoustic stimulation non-invasive neural control treatment plan corresponding to the two ear sides is obtained, generating an acoustic stimulation signal that allows people to perceive and accept changes in amplitude and frequency and can transmit sufficient energy; the sound is played through headphones. The customized acoustic stimulation signals for one ear and / or two ears are converted into electrical stimulation signals through the cochlea, enter the brain center through the auditory pathway, and actively perform parameter-adjustable and controllable electrical stimulation on the nervous system to achieve precise neural regulation and treatment; after multiple courses of acoustic stimulation and precise treatment, the normal discharge function of neurons is gradually restored, the chaotic signals in the nervous system are desynchronized, and the nervous system is reshaped, thereby reducing or eliminating the perception of neural dysfunction and gradually restoring the healthy state of nervous system function; personalized acoustic stimulation signals include but are not limited to stimulation rate, stimulation amplitude, stimulation waveform or melody; among them, signal waveform control includes but is not limited to triangle wave control, rectangular wave control, pulse wave control, sawtooth wave control, trough extension control, change cycle control, and waveform notch control.

[0014] In a preferred embodiment of the present invention, when conducting multi-course treatment and rehabilitation full-cycle management applicable to various chronic diseases of neurological dysfunction, the iterative cycle process of the monaural and / or binaural acoustic stimulation neuromodulation treatment plan is repeatedly executed by acquiring human auditory and / or non-auditory detection signals in real time and / or periodically, and the iteration starts from the actual initial detection and analysis to adjust and optimize the corresponding parameters of the acoustic stimulation treatment plan, so as to adjust, update and optimize the diagnosis and treatment plan to achieve the best effect of precise neuromodulation treatment; wherein, the parameters of the acoustic stimulation treatment plan include but are not limited to the amplitude and frequency of the modulation signal, the contribution weights of the relevant channels or frequency bands in the superposition synthesis of multi-channel signals, the daily treatment frequency and the treatment course.

[0015] The beneficial effects of the present invention are: it is possible to formulate and implement a multi-course neurological regulation precision treatment and rehabilitation program that combines the physiological and psychological parts of refractory chronic neurological dysfunction diseases, regularly track multiple treatment effects, objectively evaluate and predict development, qualitatively and quantitatively regulate and optimize the treatment effects of subsequent treatment programs, predict changes in neurological function status, and formulate and implement a full-cycle management program for chronic neurological dysfunction diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative work, among which:

[0017] Figure 1 It is a flow chart of a preferred embodiment of a system and method for formulating an acoustic stimulation nerve regulation treatment plan of the present invention;

[0018] Figure 2 It is a schematic diagram of the auditory physiological pathway and cognitive psychological pathway of the brain nervous system in a system and method for formulating an acoustic stimulation neural regulation treatment plan of the present invention;

[0019] Figure 3 It is a schematic diagram of the "physiological + psychological" cross-action of the central nervous system in the acoustic stimulation neural regulation treatment program formulation system and method of the present invention;

[0020] Figure 4 It is a schematic diagram of signal modulation category division in a system and method for formulating an acoustic stimulation nerve regulation treatment plan of the present invention;

[0021] Figure 5 It is a schematic diagram of a signal modulation waveform in a system and method for formulating an acoustic stimulation nerve regulation treatment plan of the present invention;

[0022] Figure 6 It is a schematic diagram of pure tone hearing waveform in a system and method for formulating an acoustic stimulation nerve regulation treatment plan of the present invention;

[0023] Figure 7 It is a schematic diagram of brainstem auditory evoked potential ABR waveform in a system and method for formulating an acoustic stimulation neural regulation treatment plan of the present invention;

[0024] Figure 8 It is a schematic diagram of an event-related evoked potential (ERP) waveform in a system and method for formulating an acoustic stimulation neural regulation treatment plan of the present invention;

[0025] Fig. 9 It is a schematic diagram of an EEG power spectrum density waveform in a system and method for formulating an acoustic stimulation neural regulation treatment plan of the present invention;

[0026] Fig.10 It is a schematic diagram of a typical acoustic stimulation signal wave (loudness-time) in a system and method for formulating an acoustic stimulation nerve regulation treatment plan of the present invention;

[0027] Fig.11 It is another typical acoustic stimulation signal wave (loudness-time) schematic diagram in a system and method for formulating an acoustic stimulation nerve regulation treatment plan of the present invention;

[0028] Fig.12 is a schematic diagram of a system for formulating an acoustic stimulation neural regulation treatment plan of the present invention;

[0029] Fig.13 It is a schematic diagram of the internal structure of a system for formulating an acoustic stimulation nerve regulation treatment plan of the present invention. DETAILED DESCRIPTION

[0030] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0031] See also Figure 1-13 , the embodiment of the present invention includes:

[0032] A system for formulating an acoustic stimulation neuromodulation treatment plan is suitable for formulating a universal multi-channel multi-modal acoustic stimulation non-invasive neuromodulation treatment plan for a variety of intractable neurological dysfunction diseases, and includes: a neurological dysfunction detection signal input interface unit for receiving auditory and / or non-auditory detection signals, a signal preprocessing unit, an acoustic stimulation plan formulation and storage unit, and an acoustic stimulation plan implementation unit.

[0033] Among them, various neurological dysfunction diseases include but are not limited to tinnitus, deafness, sleep disorders, anxiety, depression, vertigo, Meniere's disease, sudden deafness, stuffy ears, migraine, nervous fatigue, epilepsy, Parkinson's disease, ADHD, autism, bad habits, Alzheimer's disease and dementia.

[0034] Regarding human auditory detection signals, the subjective detection signals and / or objective detection signals of the human auditory nerve are input into a signal preprocessing unit through a brain-computer interface to perform signal typing and conversion analysis on the subjective detection signals and / or objective detection signals.

[0035] The corresponding subjective auditory test on each ear side includes but is not limited to the hearing threshold in a living noise environment, and the ultra-high frequency pure tone audiometry is extended from the conventional hearing frequency range of 1Hz to 8KHz to above 10KHz; the corresponding semi-objective and semi-subjective auditory test on each ear side includes but is not limited to multi-channel multi-modal psychoacoustic tinnitus sound matching or restoration detection for tinnitus sound restoration, and the sub-signals of each channel are expressed in simple sound elements, sound intensity, frequency range and / or melody, that is, tinnitus is matched by simple sound elements of multiple channels to obtain simple sound elements expressing complex tinnitus sounds, and only simple sound elements can be subjected to signal modulation processing expressed by mathematical formulas, wherein simple sound elements include but are not limited to pure tones, pulses, and noises; the corresponding objective auditory test on each ear side includes but is not limited to auditory brainstem evoked potential ABR detection and / or auditory multi-frequency steady-state evoked potential ASSR detection for auditory brainstem potential wave changes, event-related evoked potential ERP detection for detecting cognitive behavioral psychological activities and psychological reaction functions, and endogenous event-related evoked potential P300 detection.

[0036] Regarding the non-auditory detection signals of the human body, the neural electrical activity signals obtained by non-auditory objective detection are input into the input signal preprocessing unit through the brain-computer interface for signal typing and conversion analysis. The non-auditory detection signals of the human body include but are not limited to detection signals that characterize the electrophysiological activity of each brain functional area, the interaction of multiple brain functional areas, the dynamic changes of EEG signals, the changes or differences in neural network properties and energy, etc. The non-auditory detection of the human body includes but is not limited to EEG signal detection and EEG-based event-related evoked potential ERP detection.

[0037] A method for formulating an acoustic stimulation nerve regulation treatment plan, the steps of which include:

[0038] (1) For each chronic disease characteristic of neurological dysfunction, reflecting the interaction between the physiological and psychological parts of the disease, whether it is a human auditory psychoacoustic detection signal or a human non-auditory neural biofeedback signal, the auditory and / or non-auditory detection fluctuation signals expressed in different physical quantities are subjected to signal typing and conversion analysis respectively, so as to decompose the signal into multiple signal components suitable for signal modulation processing and extract the signal characteristic parameters.

[0039] (1.1) The steps of typing and conversion analysis of human auditory and / or non-auditory detection signals include:

[0040] (1.1.1) Select the waveform of the auditory detection signal and the waveform of the non-auditory detection signal.

[0041] (1.1.2) Through mathematical transformation and analysis of signal waves, obtain relevant fluctuation signals containing parameters such as amplitude and frequency, which reflect different physical quantities of brain region electrophysiological activity and multi-brain region interaction. Mathematical transformation and analysis of signal waves include but are not limited to fast Fourier transform (FFT) analysis of the signal in the time domain and frequency domain, wavelet transform (WT) time-frequency analysis, power spectrum density analysis of EEG signals, and neural network attribute analysis.

[0042] (1.1.3) Decompose the multimodal composite electrophysiological activity signal with multiple frequency points or multiple peak-valley segments into multiple simple signal components in different frequency bands or with different characteristics. Different signal components correspond to multiple signal processing or algorithm channels. Analyze the neurological dysfunction electrical activity signal components in each signal channel and extract signal characteristic parameters. The signal characteristic parameters include but are not limited to the signal waveform, amplitude A corresponding to each channel. m , frequency f m .

[0043] (1.1.4) In the analysis of the input signals reflecting various neural activities, further perform typing analysis on the complex waveforms that express the dynamic changes of neural physiological activities and cognitive psychological activities separately and in combination with each other, so as to further adjust and optimize the characteristic parameters of the signal components in step (1.1.3). Further typing analysis includes but is not limited to waveform mutation analysis, signal curve mutation tangent point analysis, and specificity division analysis.

[0044] (2) Inputting the signal components and signal characteristic parameters into corresponding multiple single signal processing channels, using a multi-channel multi-modal acoustic modulation signal processing algorithm, and performing acoustic signal modulation processing on each signal processing channel at the same time. The multi-channel multi-modal acoustic modulation signal processing algorithm includes but is not limited to signal modulation algorithms of amplitude modulation SAM, frequency modulation SFM, and amplitude modulation and frequency modulation hybrid SAFM using trigonometric functions.

[0045] During implementation, according to the multi-channel multi-modal neural dysfunction electrical signal characteristic parameters in step (1.1.4) (including but not limited to the signal waveform and amplitude A corresponding to each channel), m , frequency f m ), combined with the neurological dysfunction classification analysis in step (1.1.3), the corresponding multi-channel multi-modal acoustic modulation signal is obtained through the multi-channel multi-modal acoustic modulation signal processing algorithm.

[0046] Perform signal modulation processing on the signal components of each signal channel separately:

[0047] (2.1) First, select the modulation wave trigonometric function and set the carrier trigonometric function; the parameters of the modulation wave trigonometric function are derived from the characteristic parameter values ​​reflecting the neural electrical activity signal components in each channel, including but not limited to the main frequency point or sub-frequency band frequency value f m And the hearing threshold amplitude change value A set not to exceed 20dB m , according to the preset amplitude modulation coefficient (less than 1) and frequency modulation coefficient range (0.1% - 10%) based on the modulation wave ratio, the amplitude value A of the carrier trigonometric function is obtained. c and frequency value f c ; Signal trigonometric function modulation includes but is not limited to sinusoidal wave amplitude modulation SAM, sinusoidal wave frequency modulation SFM, and sinusoidal wave amplitude-frequency mixed modulation SAFM.

[0048] An implementation example, Sinusoidal Amplitude Modulation (SAM) includes:

[0049] The signal characteristic parameters are obtained from the neural detection signal processing and used as the amplitude A of the input signal to be modulated. m and frequency f m .

[0050] Set carrier signal D (t) Mathematical expression of sine wave:

[0051] D (t) = A c *sin(2πf c t).

[0052] In the formula, A c is the carrier amplitude, f c is the carrier frequency and t is the time.

[0053] A c = m*A m , m is the amplitude modulation coefficient, 0≤m≤1, f c According to the modulation requirements or according to f m It is set as a certain percentage (for example: 0.1% - 10%).

[0054] Modulation amplitude A (t) Mathematical expression of a sine wave varying with time:

[0055] A (t) = [1 + m*sin(2πf m t)]

[0056] In the formula, f m is the modulation frequency.

[0057] Therefore, the mathematical expression of the sine wave after signal amplitude modulation is:

[0058] D (t) = (A c *A (t) )*sin(2πf c t)

[0059] = A c *[1 + m*sin(2πf m t)]*sin(2πf c t)

[0060] In the formula, only time t is a trigonometric variable.

[0061] Different from the prior art, in this application, the clinical diagnostic information is combined with the characteristic parameters A of the neural signal components obtained by clinical auditory and / or non-auditory brain activity detection signal typing and conversion analysis and signal decomposition. m and f m As input, the carrier function parameter A c and f c The setting method first performs simple signal modulation in each channel, and then outputs and synthesizes the signal to obtain a synthetic acoustic modulation signal that reflects complex brain activity signals. The signal is input into the ear canal and converted into a stimulating electrical signal through the cochlea, and enters the brain center through the auditory pathway to electrically stimulate the cranial nervous system for neurological regulation, making it possible to perform precise neurological regulation treatment for various intractable neurological dysfunction diseases.

[0062] (2.2) Output unilateral or bilateral modulated acoustic signals for each channel to synthesize multi-channel multi-modal acoustic stimulation schemes.

[0063] (3) The modulated acoustic signals output by each channel are superimposed and / or compounded, and combined with diagnostic information, the signal synthesis and signal modulation parameters are further optimized to develop personalized acoustic stimulation treatment plans for different types of chronic diseases of neurological dysfunction. Diagnostic information includes but is not limited to hearing threshold information, sleep information, anxiety information, actual depression status information, and various clinical subjective scale assessment information reflecting mental psychology.

[0064] (3.1) The modulated acoustic signals output by each channel are simply superimposed and / or compounded, or the modulated acoustic signals output by each channel are superimposed and / or compounded according to the pre-set contribution weights of each channel to form a multi-channel multi-modal composite modulated acoustic signal.

[0065] (3.2) Through the analysis of neural electrical activity signal typing and combined with clinical diagnosis information, the multi-channel multi-modal composite modulated sound signal corresponding to each ear side is further superimposed with background sound and signal waveform regulation, and superimposed with the hearing threshold of the corresponding main frequency point detected in step (1), so as to obtain a personalized single-ear and / or double-ear multi-channel multi-modal acoustic stimulation non-invasive neural regulation precision treatment plan. Among them, the signal waveform regulation includes but is not limited to triangle wave regulation, rectangular wave regulation, pulse wave regulation, sawtooth wave regulation, trough extension regulation, change cycle regulation, and waveform notch regulation.

[0066] (4) The personalized acoustic stimulation treatment plan is input into the ear canal (auditory nerve channel) on the corresponding ear side through the earphone, and converted into an electrical stimulation signal by the cochlea, which stimulates the nervous system with adjustable and controllable parameters, promotes the nervous system to return to normal state, and simultaneously conducts "physiological + psychological" comprehensive physical intervention non-invasive neuro-regulatory acoustic stimulation treatment for different types of intractable chronic diseases of neurological dysfunction, realizing the full cycle management of multi-course treatment and rehabilitation of chronic diseases of neurology.

[0067] like Figure 2 As shown in the figure, the solid-line box is the objective auditory physiological pathway, and the dotted-line box is the subjective cognitive psychological pathway. When patients with various neurological dysfunctions are treated with "physiological + psychological" comprehensive physical intervention non-invasive neuroregulatory treatment, the personalized acoustic stimulation treatment plan with neuroregulatory function is played through headphones, which is converted into electrical stimulation signals through the cochlea, and enters the central nervous thalamus and hippocampus along the auditory nerve pathway for further signal classification and processing; then it is transmitted to the corresponding cerebral cortex according to the classification of human brain electrical signals, and the electrical stimulation signals activate a large number of neurons passing through the nervous system, and the neurons generate electrical excitement to further amplify the electrical stimulation signals and promote transmission; after multiple courses of acoustic stimulation, that is, conversion to electrical stimulation treatment, the normal discharge function of neurons is gradually restored, the chaotic signals in the nervous system are desynchronized, and the nervous system is reshaped, thereby reducing or removing the perception of neurological dysfunction and gradually restoring the healthy state of nervous system function.

[0068] In order to achieve the effect of acoustic stimulation regulating the nervous system and neurons in different brain functional areas, it is necessary to comprehensively consider the energy required for each stimulation, the rate of change of amplitude modulation and / or frequency modulation, and the duration of stimulation, and form different neuroregulatory treatment plans in order to achieve the purpose of treating different chronic diseases of neurological dysfunction.

[0069] When implementing the full-cycle management of multi-course treatment and rehabilitation for various chronic diseases of neurological dysfunction, the neurological dysfunction test of step (1) can be performed according to the changes in the patient's condition and / or regularly to evaluate the treatment effect and changes in the condition, and the iterative cycle process of steps (1) to (4) can be repeated in a timely manner, starting with the initial test and analysis that may not accurately reflect the actual condition of the patient, and gradually adjusting and optimizing the relevant parameters of the corresponding acoustic stimulation treatment plan. The parameters include but are not limited to the amplitude and frequency of the modulation signal, the contribution weights of the relevant channels or frequency bands in the superposition synthesis of multi-channel signals, the daily treatment frequency and multiple courses of treatment. The diagnosis and treatment plan is adjusted, updated and optimized regularly to improve the efficacy until the patient feels that the condition has improved and / or the electrophysiological signal detection reflects significant changes, thereby improving patient satisfaction.

[0070] A method for formulating an acoustic stimulation neuromodulation treatment plan, the basic principle of which is about the collection, processing, processing and application of neural electrical signals applicable to a variety of intractable chronic diseases of neurological dysfunction. Based on the characteristics of electrical signals that are easy to transmit over the network, it can be further upgraded and expanded to the fields of digital medicine and cloud services, covering more regions and people, patients, doctors and experts at all levels. In addition, steps (1)-(4) can be used as a general neuromodulation technology approach and method, and applied to physical examinations, efficacy evaluation and health management of a variety of chronic diseases of neurological dysfunction.

[0071] The beneficial effects of the acoustic stimulation neuromodulation treatment program formulation system and method of the present invention are: it can formulate and implement a multi-course neuromodulation treatment rehabilitation program that combines the physiological and psychological parts of refractory chronic neurological dysfunction diseases, regularly track multiple treatment effects, objectively evaluate and predict development, qualitatively and quantitatively regulate and optimize the treatment effects of subsequent treatment programs, predict changes in neurological function status, and formulate and implement a full-cycle management program for chronic neurological dysfunction diseases.

[0072] The above descriptions are merely embodiments of the present invention and are not intended to limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made using the contents of the present invention specification, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A device for formulating an acoustic stimulation nerve regulation treatment plan, characterized in that the steps include: Human auditory psychoacoustic detection signals and human non-auditory neural biofeedback detection signals are input through the brain-computer interface, and the different auditory and non-auditory detection fluctuation signals on the two ear sides expressed in different physical quantities are respectively subjected to signal typing and conversion analysis to decompose the signal into multiple signal components on different ear sides suitable for signal modulation processing, and extract signal characteristic parameters; the signal components and characteristic parameters of each ear side are respectively input into multiple single signal processing channels, and a multi-channel multi-modal acoustic modulation signal processing algorithm is adopted to first simultaneously perform acoustic signal modulation processing on each signal processing channel, and then the acoustic modulation signals output by each channel are superimposed and / or compounded, and the diagnostic information of neurological dysfunction diseases is combined to perform signal synthesis and signal modulation parameter optimization, and one or more multi-channel multi-modal personalized acoustic stimulation signals on each ear side are output or compounded for different types of neurological dysfunction chronic diseases. Stimulate non-invasive neuromodulation treatment plan; personalized non-invasive neuromodulation treatment plan is implemented by inputting auditory nerve channels through earphones on the left and / or right ear respectively, and at the same time, comprehensive physical intervention non-invasive neuromodulation acoustic stimulation precision treatment combining physiology and psychology is carried out to achieve multi-course personalized treatment and rehabilitation full-cycle management of chronic neurological diseases. When conducting multi-course treatment and rehabilitation full-cycle management applicable to various chronic diseases of neurological dysfunction, the human auditory and non-auditory detection signals are obtained in real time and / or timed manner, and the iterative cycle process of the acoustic stimulation neuromodulation treatment plan of one ear and / or two ears is repeatedly executed to adjust and optimize the corresponding parameters of the acoustic stimulation treatment plan, so as to adjust, update and optimize the diagnosis and treatment plan to achieve the best effect of neuromodulation precision treatment; wherein, the diagnostic information of neurological dysfunction diseases includes but is not limited to hearing threshold information, sleep information, anxiety information, and depression information; Objective tests include event-related evoked potential (ERP) and endogenous event-related evoked potential (P300) tests for detecting cognitive behavioral psychological activities and psychological response functions; When obtaining non-auditory detection signals of the human body, the non-auditory detection signals obtained by non-auditory objective detection are input into a signal preprocessing unit through a brain-computer interface to perform signal typing and conversion analysis; non-auditory detection signals of the human body include but are not limited to detection signals representing the electrophysiological activity of each brain functional area, the interaction of multiple brain functional areas, the dynamic changes of EEG signals, the changes or differences in neural network properties and energy, and non-auditory objective detection methods include but are not limited to EEG signal detection and EEG-based event-related evoked potential ERP detection; The steps of performing signal typing and conversion analysis on human auditory and / or non-auditory detection signals include: selecting auditory detection signal waveforms and non-auditory detection signal waveforms; obtaining a wave signal containing amplitude and frequency parameters of different physical quantities reflecting the electrophysiological activity of brain regions and the interaction of multiple brain regions through mathematical transformation and analysis of signal waves; when a complex wave signal has multiple frequency points or multiple peak and trough segments, the complex wave signal should be decomposed into multiple signal components located in different frequency bands or with different wave characteristics, and the signal components are analyzed separately to extract signal characteristic parameters; When the signal components of each signal channel are subjected to signal modulation processing respectively: firstly, the modulation wave trigonometric function is selected and the carrier trigonometric function is set, and the signal components are subjected to trigonometric function modulation processing, and the trigonometric function modulation processing includes but is not limited to sinusoidal wave amplitude modulation SAM, sinusoidal wave frequency modulation SFM, and sinusoidal wave amplitude-frequency mixed modulation SAFM; then, the unilateral or bilateral modulated sound signal of each channel is output for subsequent multi-channel multi-modal acoustic stimulation scheme synthesis; wherein, the parameters of the modulation wave trigonometric function are derived from the characteristic parameter values ​​reflecting the neural electrical activity signal components in each channel, and the characteristic parameter values ​​of the signal components include but are not limited to the main frequency point or the sub-frequency band frequency value f m And the hearing threshold amplitude change value A set not to exceed 20dB m , the amplitude value A of the carrier trigonometric function is obtained according to the preset amplitude modulation coefficient and frequency modulation coefficient based on the modulation wave ratio. c and frequency value f c , where the amplitude modulation coefficient is less than 1.0 and the frequency modulation coefficient ranges from 0.1% to 10%; When formulating a personalized acoustic stimulation treatment plan, the modulated acoustic signals output by each channel are directly superimposed and / or compounded according to the pre-set contribution weights of each channel to form a multi-channel, multi-modal, composite modulated acoustic signal; the composite modulated acoustic signals on both ear sides are further processed by background sound superposition and signal waveform control, and the processed control amplitude is superimposed with the hearing threshold of the main frequency point corresponding to the wave signal detected or transformed on the corresponding ear side of the human body, and after the volume is balanced and adjusted for the left and right ears, a personalized multi-channel, multi-modal acoustic stimulation non-invasive neural control treatment plan corresponding to both ear sides is obtained, so as to generate an acoustic stimulation signal that can transmit sufficient energy and can allow people to perceive and accept changes in amplitude and frequency.

2. The device for formulating an acoustic stimulation nerve regulation treatment plan according to claim 1, characterized in that: When obtaining auditory detection signals from both ears of a human body, the subjective detection signals and / or objective detection signals of the auditory nerves on each ear side of the human body are respectively input into a signal preprocessing unit through a brain-computer interface to perform signal typing and conversion analysis; subjective detection includes but is not limited to hearing thresholds in a living noise environment, and ultra-high frequency pure tone hearing detection extending from a conventional hearing frequency range of 1 Hz to 8 kHz to above 10 kHz; semi-objective and semi-subjective detection includes but is not limited to multi-channel multi-modal psychoacoustic tinnitus sound matching or restoration detection for complex tinnitus sound restoration, and the signal components of each channel are respectively expressed in simple sound elements, sound intensity, frequency range and / or melody, and simple sound elements are respectively expressed in simple sound elements, but are not limited to pure tone, pulse, and noise; objective detection includes auditory brainstem evoked potential ABR detection and / or auditory multi-frequency steady-state evoked potential ASSR detection for changes in auditory brainstem potential waves.

3. The device for formulating an acoustic stimulation nerve regulation treatment plan according to claim 1, characterized in that: Mathematical transformation and analysis of signal waves include but are not limited to fast Fourier transform (FFT) analysis of time and frequency domains, wavelet transform (WT) time-frequency analysis, power spectrum density analysis of EEG signals and neural network attribute analysis. Signal characteristic parameters include but are not limited to the signal waveform and amplitude A corresponding to each signal component. m , frequency f m .

4. The device for formulating an acoustic stimulation nerve regulation treatment plan according to claim 1, characterized in that: When performing typing and conversion analysis on the subjective and / or objective detection signals reflecting the physiological and psychological parts of neurological dysfunction diseases, further typing analysis is performed on the complex waveforms that express the dynamic changes of neurophysiological activities and cognitive psychological activities separately and interactively. Further typing analysis includes but is not limited to waveform mutation analysis, notch point analysis of signal curve mutation, and specificity division analysis, so as to further adjust and optimize the characteristic parameters of signal components.

5. The device for formulating an acoustic stimulation nerve regulation treatment plan according to claim 4, characterized in that: According to the typing and conversion analysis results of the human neuroelectrophysiological detection signals, combined with clinical subjective diagnostic information including but not limited to clinical characteristic information on sleep, anxiety, depression, and sound sensitivity and their psychiatric subjective scale evaluation information, the characteristic parameters of the signal components are further adjusted and optimized.

6. The device for formulating an acoustic stimulation nerve regulation treatment plan according to claim 1, characterized in that: Signal waveform control includes but is not limited to triangle wave control, rectangular wave control, pulse wave control, sawtooth wave control, trough extension control, variation cycle control, and waveform notch control.

7. The device for formulating an acoustic stimulation nerve regulation treatment plan according to claim 1, characterized in that: The parameters of the acoustic stimulation therapy program include, but are not limited to, the amplitude and frequency of the modulation signal, the contribution weights of the relevant channels or frequency bands in the multi-channel signal superposition synthesis, the daily treatment frequency and the treatment course.

8. The device for formulating an acoustic stimulation nerve regulation treatment plan according to claim 1, characterized in that: The system for formulating an acoustic stimulation neuromodulation treatment plan includes: a neurological dysfunction detection signal input interface unit, a signal preprocessing unit, an acoustic stimulation plan formulation and storage unit, and an acoustic stimulation plan implementation unit. The fluctuating signals detected by human hearing and / or non-hearing that express brain activity in a variety of physical quantities are input into the signal preprocessing unit through the brain-computer interface and the signal input interface unit to perform neuroelectrophysiological signal typing and conversion analysis on the signals. The acoustic stimulation plan formulation and storage unit formulates personalized acoustic stimulation treatment plans corresponding to the two ear sides according to the processing information output by the signal preprocessing unit, so as to perform comprehensive physical intervention acoustic stimulation non-invasive neuromodulation precision treatment that combines physiology and psychology. The acoustic stimulation plan implementation unit inputs the acoustic stimulation signal into the ear canal and converts it into a stimulation electrical signal through the cochlea, which enters the brain center through the auditory pathway to perform electrical stimulation neuromodulation on the cranial nervous system, thereby achieving neuromodulation precision treatment for various intractable neurological dysfunction diseases, and carrying out multi-course personalized treatment and rehabilitation full-cycle management of chronic neurological diseases.

Images