A portable active inhalation drug delivery device based on MEMS

Abstract

The present invention discloses a portable active inhalation drug delivery device based on MEMS, comprising: a liquid medicine box, an oil guide plate, a porous oil guide member, an atomization chip, a base, a PCB board and a suction nozzle, a liquid medicine guide port is provided at the bottom of the liquid medicine box, a symmetrically arranged air intake through hole is provided on one opposite side wall of the liquid medicine box, an air intake groove is provided on the oil guide plate, two air intake through holes are symmetrically arranged at both ends of the air intake groove, the porous oil guide member is fixedly mounted on the back of the oil guide plate, the atomization chip is fixedly mounted on the mounting seat of the base, the PCB board is fixedly mounted on the back of the base, a first aerosol channel is provided in the mounting seat, a metal electrode is provided on the mounting seat, the suction nozzle is fixedly mounted on the base, and a second aerosol channel is provided in the suction nozzle. Compared with the prior art, the present invention has uniform atomization of liquid medicine, a high proportion of liquid medicine particles with a target diameter, and active inhalation drug delivery, which effectively controls the dosage and prevents choking and coughing.

Description

Technical Field

[0001] The present invention belongs to the field of MEMS medical technology, and in particular relates to a portable active inhalation drug delivery device based on MEMS. Background Art

[0002] At present, with the diversification of life and the aggravation of environmental pollution, respiratory diseases have become common diseases, such as asthma and COPD, and the number of patients is still increasing. Generally, chronic respiratory diseases require long-term treatment, and the choice of treatment method is crucial. Studies have shown that inhalation is the simplest and most effective route of administration for the treatment of respiratory diseases such as asthma and COPD.

[0003] Inhalation therapy is a method of atomizing liquid medicine to form an aerosol, and completing the treatment through the patient's inhalation action. Through the inhalation action, the liquid medicine aerosol reaches the respiratory tract from the mouth, then to the lungs, and diffuses in the lungs to reach the lesion site. The inhalation treatment method can directly apply the liquid medicine to the lesion site, which is direct, quick, safe and has few side effects. Depending on the diameter of the liquid medicine particles, the absorption of the liquid medicine in the respiratory tract and lungs is also different. For adults, particles with a diameter of 0.5 to 1.0um can be effectively deposited in the respiratory bronchi and alveoli, particles with a diameter of 1.0-5.0um are mostly absorbed in the 10th to 17th level bronchi, and particles with a diameter of 5.0 to 8.0um, most of the liquid medicine is deposited in the throat and respiratory tract. The more 1.0 to 3.0um liquid medicine particles produced by the inhalation drug delivery device, the greater the proportion, and the better the efficacy.

[0004] The existing portable inhalation drug delivery devices have poor atomization effect on drug liquid, and the generated drug liquid particles with a diameter of 1.0 to 3.0 um account for a limited proportion, which affects the effective absorption of the drug and leads to a longer treatment cycle. At the same time, the existing portable inhalation drug delivery devices mostly adopt a passive form, forming a high-pressure airflow by pushing and pressing to spray out the drug liquid, which can easily cause patients to choke and cough, and is inconvenient to use. Summary of the invention

[0005] The purpose of the present invention is to provide a portable active inhalation drug delivery device based on MEMS, in which the drug liquid is evenly atomized, the target diameter drug liquid particles account for a high proportion, and the drug is delivered by active inhalation, so as to effectively control the dosage and prevent choking.

[0006] In order to achieve the above-mentioned purpose, the present invention adopts the following technical scheme: a portable active inhalation drug delivery device based on MEMS, comprising: a liquid medicine box, an oil guide plate, a porous oil guide part, an atomization chip, a base, a PCB board and a nozzle, a liquid medicine guide port is arranged at the bottom of the liquid medicine box, the oil guide plate is connected to the card slot on the side wall of the liquid medicine box through a snap buckle, symmetrically arranged air inlet holes are arranged on one opposite side wall of the liquid medicine box, a liquid medicine through hole corresponding to the liquid medicine guide port is arranged on the oil guide plate, an air inlet groove is arranged on the oil guide plate, two air inlet holes are symmetrically arranged at both ends of the air inlet groove, and the porous The oil guide piece is fixedly mounted on the back of the oil guide plate, the position of the porous oil guide piece is correspondingly arranged below the liquid medicine through hole, the atomizer chip is fixedly mounted on the mounting seat of the base, the PCB board is fixedly mounted on the back of the base, a battery is arranged below the PCB board, a first aerosol channel is arranged in the mounting seat, a metal electrode is arranged on the mounting seat, the top contact of the metal electrode is in electrical contact with the resistance wire of the atomizer chip, and the bottom of the metal electrode is electrically connected to the connecting column of the PCB board, the nozzle is fixedly mounted on the base, a second aerosol channel is arranged in the nozzle, and the second aerosol channel is connected to the first aerosol channel.

[0007] As a further description of the above technical solution:

[0008] The bottom of the medicine liquid box is provided with two symmetrically arranged guide parts, and the medicine liquid guide port is arranged at the bottom of the guide part.

[0009] As a further description of the above technical solution:

[0010] Two porous oil guide members are arranged below the oil guide plate, and the two porous oil guide members are symmetrically arranged on both sides of the air intake groove.

[0011] As a further description of the above technical solution:

[0012] The porous oil guide member is fixedly installed in a second groove arranged on the back side of the oil guide plate.

[0013] As a further description of the above technical solution:

[0014] The surface of the oil guide plate is provided with a first groove extending along the circumference of the liquid medicine through hole, and a first sealing ring is arranged in the first groove.

[0015] As a further description of the above technical solution:

[0016] The porous oil guide piece is porous cotton or porous ceramic.

[0017] As a further description of the above technical solution:

[0018] The atomization chip also includes a silicon-based substrate, on which an array of atomization through holes is arranged, a porous oil guide member is against the surface of the silicon-based substrate, a resistance wire is made on the back of the silicon-based substrate, and a top contact of the metal electrode is in electrical contact with a contact electrode at the end of the resistance wire.

[0019] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0020] 1. In the present invention, an atomization chip based on MEMS technology is used. The size and depth of the atomization through holes on the silicon-based substrate in the atomization chip are easy to process, and the atomization through hole structure is uniform, so that the liquid medicine is atomized uniformly and the proportion of liquid medicine particles with target diameter is high.

[0021] 2. In the present invention, the MEMS atomization chip is thermally driven, that is, by controlling the chip resistance wire, the drug liquid is actively aerosolized, improving the unpleasant experience brought by the passive inhalation drug delivery device. And the heating resistance wire prepared by semiconductor technology on the silicon-based substrate can provide sufficient heat energy at a relatively low power (such as tens of milliwatts) to excite the drug liquid into aerosol.

[0022] 3. In the present invention, the porous oil guide realizes the storage and locking of the liquid medicine before it reaches the atomization chip, and assists in the preliminary dispersion of the liquid medicine. At the same time, since the porous oil guide already has the functions of storing and locking liquid, the MEMS atomization chip structure can simplify the liquid storage and locking design, and only needs to refine and disperse the liquid medicine and atomize it. The MEMS atomization chip structure is further simplified, reducing the complexity of the structure, reducing the difficulty of manufacturing, and reducing the manufacturing cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

[0024] Figure 1 This is a schematic diagram of the structure of a portable active inhalation drug delivery device based on MEMS.

[0025] Figure 2 This is a schematic diagram of the structural breakdown of a portable active inhalation drug delivery device based on MEMS.

[0026] Figure 3 A cross-sectional view of a portable active inhalation drug delivery device based on MEMS.

[0027] Figure 4 This is a schematic diagram of the structure of a drug liquid box in a portable active inhalation drug delivery device based on MEMS.

[0028] Figure 5 This is a schematic diagram of the structure of an oil guide plate in a portable active inhalation drug delivery device based on MEMS.

[0029] Figure 6 This is a schematic diagram of the structure of an atomizer chip in a portable active inhalation drug delivery device based on MEMS.

[0030] Legend:

[0031] 1. Medicine liquid box; 11. Card slot; 12. Air inlet hole; 13. Guide part; 2. Oil guide plate; 21. Buckle; 22. Medicine liquid hole; 23. Air inlet groove; 24. First sealing ring; 25. Second groove; 3. Porous oil guide member; 4. Atomization chip; 41. Resistance wire; 411. Contact electrode; 42. Silicon-based substrate; 421. Atomization hole; 5. Base; 51. Mounting seat; 511. First aerosol channel; 52. Metal electrode; 6. PCB board; 61. Battery; 62. Connecting column; 7. Nozzle; 71. Second aerosol channel. DETAILED DESCRIPTION

[0032] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0033] See also Figure 1-6The present invention provides a technical solution: a portable active inhalation drug delivery device based on MEMS, comprising: a liquid medicine box 1, an oil guide plate 2, a porous oil guide member 3, an atomization chip 4, a base 5, a PCB board 6 and a nozzle 7, a liquid medicine guide port is arranged at the bottom of the liquid medicine box 1, the oil guide plate 2 is snapped into a card slot 11 on the side wall of the liquid medicine box 1 through a snap 21, symmetrically arranged air inlet holes 12 are arranged on an opposite side wall of the liquid medicine box 1, a liquid medicine through hole 22 corresponding to the position of the liquid medicine guide port is arranged on the oil guide plate 2, an air inlet groove 23 is arranged on the oil guide plate 2, two air inlet holes 12 are symmetrically arranged at both ends of the air inlet groove 23, and the porous oil guide member 3 is fixedly mounted on the oil guide plate 2 On the back side, the porous oil guide member 3 is correspondingly arranged below the liquid medicine through hole 22, the atomizer chip 4 is fixedly mounted on the mounting seat 51 of the base 5, the PCB board 6 is fixedly mounted on the back side of the base 5, a battery 61 is arranged below the PCB board 6, a first aerosol channel 511 is arranged in the mounting seat 51, a metal electrode 52 is arranged on the mounting seat 51, the top contact of the metal electrode 52 is electrically in contact with the resistance wire 41 of the atomizer chip 4, and the bottom of the metal electrode 52 is electrically connected to the connecting column 62 of the PCB board 6, the suction nozzle 7 is fixedly mounted on the base 5, a second aerosol channel 71 is arranged in the suction nozzle 7, and the second aerosol channel 71 is connected to the first aerosol channel 511.

[0034] Two symmetrically arranged guide parts 13 are provided at the bottom of the liquid medicine box 1 . The liquid medicine guide port is provided at the bottom of the guide part 13 . The guide part 13 is a tapered structure that is wide at the top and narrow at the bottom, so as to better guide the liquid medicine into the oil guide plate 2 .

[0035] Two porous oil guides 3 are provided below the oil guide plate 2. The two porous oil guides 3 are symmetrically arranged on both sides of the air inlet groove 23, so that the medicine liquid can be better mixed with the air flowing in through the air inlet groove 23 to form an aerosol, thereby improving the atomization effect.

[0036] The porous oil guide member 3 is fixedly installed in the second groove 25 arranged on the back side of the oil guide plate 2, so that the porous oil guide member 3 is firmly installed and not easily deformed, thereby ensuring the liquid storage and liquid locking effects.

[0037] The surface of the oil guide plate 2 is provided with a first groove extending circumferentially along the liquid through hole 22, and a first sealing ring 24 is provided in the first groove. The first sealing ring 24 can be made of sealing materials such as rubber and glue to improve the sealing effect and avoid leakage.

[0038] The porous oil guide member 3 is porous cotton or porous ceramic, and has good liquid storage and liquid locking effects.

[0039] The atomization chip 4 also includes a silicon-based substrate 42, on which an array of atomization through holes 421 are arranged. The porous oil guide member 3 is against the surface of the silicon-based substrate 42. The resistance wire 41 is made on the back of the silicon-based substrate 42. The top contact of the metal electrode 52 is in electrical contact with the contact electrode 411 at the end of the resistance wire 41. The PCB board 6 provides energy to the resistance wire 41 through a battery 61 arranged on the back.

[0040] Working principle: When the drug delivery device is working, the drug liquid is stored in the drug liquid box 1 and flows into the oil guide plate 2 through the drug liquid guide port. The setting of the oil guide plate 2 separates the drug liquid from the aerosol; the drug liquid flows into the porous oil guide member 3 through the oil guide plate 2. The porous oil guide member 3 absorbs the drug liquid, completes the storage and locking of the drug liquid, and assists in the preliminary dispersion of the drug liquid; the setting of the porous oil guide member 3 can avoid direct contact between the atomization chip 4 and the drug liquid guide port of the drug liquid box 1 to avoid leakage. The porous oil guide member 3 contacts both ends of the atomization chip 4 to guide the drug liquid to the surface of the atomization chip 4. When the atomization chip 4 atomizes the drug liquid, the drug liquid mixes with the air flowing into the drug delivery device through the air inlet hole 12 on the drug liquid box 1, and is atomized to form an aerosol, and flows out of the drug delivery device from the first aerosol channel 511 and the second aerosol channel 71 in sequence.

[0041] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A portable active inhalation drug delivery device based on MEMS, characterized in that: include: A medicine liquid box (1), an oil guide plate (2), a porous oil guide member (3), an atomization chip (4), a base (5), a PCB board (6) and a suction nozzle (7), wherein a medicine liquid guide port is arranged at the bottom of the medicine liquid box (1), the oil guide plate (2) is snapped into a card slot (11) on a side wall of the medicine liquid box (1) through a snap buckle (21), symmetrically arranged air inlet holes (12) are arranged on an opposite side wall of the medicine liquid box (1), the oil guide plate (2) is provided with a medicine liquid through hole (22) whose position corresponds to the medicine liquid guide port, the oil guide plate (2) is provided with an air inlet groove (23), two of the air inlet through holes (12) are symmetrically arranged at two ends of the air inlet groove (23), the porous oil guide member (3) is fixedly mounted on the back of the oil guide plate (2), and the porous oil guide member (3) is arranged at a position corresponding to the medicine liquid through hole (2 2), the atomizer chip (4) is fixedly mounted on the mounting seat (51) of the base (5), the PCB board (6) is fixedly mounted on the back of the base (5), a battery (61) is arranged below the PCB board (6), a first aerosol channel (511) is arranged in the mounting seat (51), a metal electrode (52) is arranged on the mounting seat (51), a top contact of the metal electrode (52) is electrically in contact with the resistance wire (41) of the atomizer chip (4), and a bottom of the metal electrode (52) is electrically connected to a connecting column (62) of the PCB board (6), the suction nozzle (7) is fixedly mounted on the base (5), a second aerosol channel (71) is arranged in the suction nozzle (7), and the second aerosol channel (71) is connected to the first aerosol channel (511); The bottom of the medicine liquid box (1) is provided with two symmetrically arranged guide parts (13), and the medicine liquid guide port is provided at the bottom of the guide part (13); Two of the porous oil guide members (3) are arranged below the oil guide plate (2), and the two porous oil guide members (3) are symmetrically arranged on both sides of the air inlet groove (23); The porous oil guide member (3) is fixedly mounted in a second groove (25) arranged on the back side of the oil guide plate (2).

2. A portable active inhalation drug delivery device based on MEMS according to claim 1, characterized in that: The surface of the oil guide plate (2) is provided with a first groove extending in the circumferential direction of the liquid medicine through hole (22), and a first sealing ring (24) is provided in the first groove.

3. A portable active inhalation drug delivery device based on MEMS according to claim 1, characterized in that: The porous oil guide member (3) is porous cotton or porous ceramic.

4. A portable active inhalation drug delivery device based on MEMS according to claim 1, characterized in that: The atomization chip (4) further comprises a silicon-based substrate (42), on which atomization through holes (421) are arranged in an array, the porous oil guide member (3) is against the surface of the silicon-based substrate (42), the resistance wire (41) is made on the back of the silicon-based substrate (42), and the top contact of the metal electrode (52) is in electrical contact with the contact electrode (411) at the end of the resistance wire (41).

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