Corneal contact tonometer, glasses, use method and processing method thereof

Abstract

The present disclosure proposes a corneal contact tonometer, glasses, a method of use and a processing method thereof, comprising a corneal contact lens base, a resonant inductance sensor and a comb-tooth capacitance sensor; the resonant inductance sensor and the comb-tooth capacitance sensor are connected and adhered to the surface of the corneal contact lens base; the corneal contact lens base is a hemispherical shell, the resonant inductance sensor is an annular toothed structure composed of a conductive material, and the resonant inductance sensor is concentrically arranged with the corneal contact lens base; the comb-tooth capacitance sensor is a comb-toothed structure composed of a conductive material, and is arranged on the side of the corneal contact lens base; the present disclosure adopts a wireless method to power the sensor and read data, and designs a corneal contact lens tonometer processing technology to solve the problem of poor stability of the rigid-flexible electronic component interface.

Description

Technical Field

[0001] The present invention belongs to the technical field of corneal contact tonometer, and in particular to a corneal contact tonometer, glasses, a use method and a processing method thereof. Background Art

[0002] Glaucoma is the second largest irreversible cause of blindness in the world. The occurrence of glaucoma is caused by multiple factors, but abnormal intraocular pressure is the key factor that directly damages the retinal nerves. Intraocular pressure is the only factor that can be directly manipulated during the diagnosis and treatment of glaucoma. Therefore, in the screening and treatment of glaucoma, accurate measurement of intraocular pressure can provide key information for the diagnosis of the disease.

[0003] The existing technologies for long-term continuous monitoring of intraocular pressure mainly include: non-contact non-invasive intraocular pressure monitoring equipment, implantable invasive intraocular pressure monitoring equipment and corneal contact lens minimally invasive intraocular pressure monitoring equipment, but they are not yet fully mature in technology and cannot be widely used for clinical monitoring; among them, corneal contact lenses are highly accepted in the way people wear them and have been widely used in vision correction and cosmetic beauty; in view of the clinical needs of continuous monitoring of intraocular pressure, wearable tonometers based on corneal contact lenses are currently the most promising. When making corneal contact tonometers, the following method can be used: Dispersing micro-nanoscale conductive materials into insulating flexible substrate prepolymers can prepare flexible electronic materials, which can be used to process flexible circuits and flexible sensors. When the mass ratio of the mixed nanomaterials exceeds the percolation threshold, it will show conductivity on a macro scale. Graphene nanomaterials have good biocompatibility and can increase the sensitivity of sensors in high-frequency resonant sensing.

[0004] The inventors of the present disclosure have found that the existing wearable tonometer based on corneal contact lenses has the following problems during use and processing:

[0005] 1. In practical applications, the wearable tonometer method based on corneal contact lenses faces poor stability of the rigid-flexible electronic component interface;

[0006] 2. The organic dispersing solvent residues in the process of preparing graphene nanomaterials show biological toxicity. Summary of the invention

[0007] In order to solve the above problems, the present disclosure proposes a corneal contact tonometer, glasses, a method of use and a processing method thereof; the present disclosure adopts a wireless method to power the sensor and read the data, and designs a corneal contact lens tonometer processing technology to solve the problem of poor stability of the rigid-flexible electronic component interface; at the same time, a dry mixing method is used to prepare graphene-polydimethylsiloxane composite nanomaterials, thereby achieving the purpose of non-toxic preparation.

[0008] In order to achieve the above objectives, in a first aspect, the present disclosure provides a corneal contact tonometer, which adopts the following technical solutions:

[0009] A corneal contact tonometer, comprising a corneal contact lens base, a resonant inductance sensor and a comb-teeth capacitance sensor;

[0010] The resonant inductance sensor and the comb-teeth capacitance sensor are connected and adhered to the surface of the corneal contact lens base;

[0011] The corneal contact lens base is a hemispherical shell, the resonant inductance sensor is a ring-shaped tooth structure made of conductive material, and the resonant inductance sensor is concentrically arranged with the corneal contact lens base; the comb-tooth capacitance sensor is a comb-tooth structure made of conductive material, and is arranged on the side of the corneal contact lens base.

[0012] Furthermore, the comb-tooth capacitance of the comb-tooth capacitance sensor is a parallel connection of multiple capacitors.

[0013] Furthermore, the conductive material is graphene nanomaterial.

[0014] In order to achieve the above-mentioned purpose, in a second aspect, the present disclosure further provides a corneal contact lens, which adopts the following technical solution:

[0015] Corneal contact glasses include a lens body, an external detection coil connected to the lens body, and an independently arranged corneal contact tonometer as described in the first aspect.

[0016] Furthermore, a detection circuit is provided in the spectacles body, and the external detection coil is connected to the detection circuit; the external detection coil is concentrically arranged with the corneal contact tonometer.

[0017] Furthermore, the external detection coil is a coil composed of grid conductors; the external detection coil is arranged on the convex side of the corneal contact tonometer.

[0018] In order to achieve the above-mentioned purpose, in a third aspect, the present disclosure also provides a method for using corneal contact lenses, which adopts the following technical solution:

[0019] A method for using a corneal contact lens, using the corneal contact lens as described in the second aspect, comprising:

[0020] The pupil is located in the central blank and unobstructed area of ​​the corneal contact tonometer; the external detection coil is installed on the glasses worn, and the coil wire is staggered from the pupil area.

[0021] In order to achieve the above-mentioned purpose, in a fourth aspect, the present disclosure also provides a method for processing a corneal contact tonometer, which adopts the following technical solution:

[0022] A method for processing a corneal contact tonometer, processing the corneal contact tonometer as described in the first aspect, comprising:

[0023] mixing to prepare a nanocomposite paste;

[0024] Using a 3D printer, the paste-like nanocomposite material is printed on the contact lens substrate into a preset sensor shape;

[0025] An AC electric field was applied to the printed sensor using a micro-tungsten needle;

[0026] Maintaining an AC electric field for baking and curing;

[0027] Based on the vacuum vapor deposition method, a polyparaxylene protective layer is generated on the sensor surface.

[0028] Furthermore, the nanocomposite material includes graphene, carbon nanotubes and polydimethylsiloxane; when mixed, 1 wt % of carbon nanotubes is added based on a percolation threshold of 11 wt % of graphene by mass.

[0029] Furthermore, when an alternating electric field is applied, graphene and carbon nanotubes form a cross-linked conductive network under the action of electromotive force.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] 1. The present invention adopts a wireless method to power the sensor and read the data, and designs a processing technology for the contact lens tonometer to solve the problem of poor stability of the rigid-flexible electronic component interface;

[0032] 2. The present invention uses a dry mixing method to prepare graphene-polydimethylsiloxane composite nanomaterials, achieving the purpose of non-toxic preparation. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] The drawings in the specification that constitute a part of this embodiment are used to provide a further understanding of this embodiment. The schematic embodiments of this embodiment and their descriptions are used to explain this embodiment and do not constitute improper limitations on this embodiment.

[0034] Figure 1 It is a front view of Embodiment 1 of the present disclosure;

[0035] Figure 2 is a top view of embodiment 1 of the present disclosure;

[0036] Figure 3 This is a schematic diagram of the structure of Embodiment 2 of the present disclosure;

[0037] Figure 4 This is a flowchart of Embodiment 4 of the present disclosure;

[0038] Figure 5 The improvement effect of incorporating carbon nanotubes on the electrical conductivity of the composite material according to Example 4 of the present disclosure;

[0039] Figure 6 The improvement effect of incorporating carbon nanotubes on the elongation at break of the composite material according to Example 4 of the present disclosure;

[0040] Figure 7 The initial state of the composite nanomaterial prepared by the dry mixing method of Example 4 of the present disclosure;

[0041] Figure 8 After applying an alternating electric field of 10 kHz in Example 4 of the present disclosure, the graphene is subjected to an electromotive force torque to form an end-to-end arrangement;

[0042] Fig. 9 After applying the alternating electric field of 10kHz and 1kHz in Example 4 of the present disclosure, the graphene and the carbon nanotubes are arranged end to end;

[0043] Fig.10 The conductive nanostructure of Example 4 of the present disclosure is in an initial state where a rotation torque is induced in an electric field to generate rotation;

[0044] Fig.11 It is a schematic diagram of the principle of the conductive nanostructure of Example 4 of the present disclosure inducing a rotation torque in an electric field to generate a rotation equilibrium state;

[0045] Among them, 1. Corneal contact lens base; 2. Resonant inductance sensor; 3. Comb capacitance sensor; 4. External detection coil; 5. Pupil; 6. Eyeball; 7. Cornea of ​​the eyeball; 8. Eyeglass body; 9. Air pump; 10. Air valve; 11. First stepper motor; 12. Second component motor; 13. Third stepper motor; 14. Compliant nanomaterials; 15. Function generator; 16. High-voltage amplifier; 17. Protection resistor; 18. Graphene; 19. Carbon nanotubes; 20. Polydimethylsiloxane. DETAILED DESCRIPTION

[0046] The present disclosure is further described below in conjunction with the accompanying drawings and embodiments.

[0047] It should be noted that the following detailed descriptions are illustrative and are intended to provide further explanation of the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which the present application belongs.

[0048] Embodiment 1:

[0049] like Figure 1 As shown, this embodiment provides a corneal contact tonometer, including a corneal contact lens base 1, a resonant inductance sensor 2 and a comb-tooth capacitance sensor 3;

[0050] The resonant inductance sensor 2 and the comb-teeth capacitance sensor 3 are connected and adhered to the surface of the corneal contact lens base 1;

[0051] The corneal contact lens base 1 is a hemispherical shell, the resonant inductance sensor 2 is a ring-shaped tooth structure made of conductive material, and the resonant inductance sensor 2 is concentrically arranged with the corneal contact lens base 1; the comb-tooth capacitance sensor 3 is a comb-tooth structure made of conductive material, and is arranged on the side of the corneal contact lens base 1.

[0052] Because the eyes often move and blink, the sensor must be powered and data read wirelessly; in this embodiment, a passive RLC resonant circuit is designed, the strain sensor is designed into the RLC resonant network, and is processed on the surface of the corneal contact lens base.

[0053] In this embodiment, the comb capacitance C of the comb capacitance sensor s It can be considered as n capacitors C 0 Parallel connection:

[0054]

[0055] Among them, ε is the dielectric constant of the material, l, t and d are the length, thickness and distance between adjacent electrodes of the capacitive comb array respectively; when the radius of corneal curvature increases, l increases, t and d remain almost unchanged, and the overall capacitance value is linearly related to l.

[0056] In this embodiment, the conductive material is graphene nanomaterial.

[0057] Embodiment 2:

[0058] like Figure 3 As described above, this embodiment provides a corneal contact lens comprising a lens body 8, an external detection coil 4 connected to the lens body, and an independently arranged corneal contact tonometer as described in the first aspect.

[0059] In this embodiment, the glasses body 4 is provided with an intelligent glasses signal detection circuit, and the structure and setting of the intelligent glasses signal detection circuit are implemented using existing technologies; the external detection coil 4 is connected to the detection circuit; the external detection coil 4 is concentrically arranged with the corneal contact tonometer.

[0060] In this implementation, if Figure 2 As shown, the external detection coil 4 is a coil composed of grid wires; the external detection coil 4 is arranged on the convex side of the corneal contact tonometer.

[0061] Embodiment 3:

[0062] This embodiment provides a method for using corneal contact lenses, comprising:

[0063] When the user wears the contact lens, he adjusts the position to the center so that the pupil is located in the blank, unobstructed area in the center of the resonant inductance and comb capacitance area of ​​the contact lens, thereby avoiding blocking of the line of sight. The wearing effect is the same as that of the existing cosmetic contact lens; the external detection coil 4 is installed on the worn eyeglass body 8, and the coil wire is staggered away from the pupil area to avoid blocking of the line of sight.

[0064] Embodiment 4:

[0065] like Figure 4 As shown, this embodiment provides a method for processing a corneal contact tonometer, comprising:

[0066] mixing to prepare a nanocomposite paste;

[0067] The paste-like nanocomposite material is printed into the designed sensor shape on the contact lens substrate using a modified 3D printer;

[0068] An AC electric field was applied to the printed sensor using a micro-tungsten needle;

[0069] Maintaining an AC electric field for high temperature baking and curing;

[0070] The vacuum vapor deposition method generates a polyparaxylene protective layer on the sensor surface.

[0071] like Figure 4 As shown in the figure, it is a schematic diagram of the processing technology of corneal contact lens tonometer, which mainly includes three key steps: ultrasonic stirring, 3D printing and electro-arrangement baking and curing.

[0072] Specifically, the contact lens tonometer method is as follows:

[0073] A non-toxic and green preparation method for flexible electronic materials based on percolation threshold doping: The graphene-polydimethylsiloxane (PDMS) composite nanomaterials prepared by the traditional organic solvent mixing method have the risk of toxic organic solvent residues. In this embodiment, a non-toxic preparation process is achieved through a dry mixing method, and material properties close to those of the traditional organic solvent mixing method are achieved, providing safe and reliable flexible electronic materials for the preparation of biocompatible corneal contact lens tonometers.

[0074] In order to improve the conductive properties of dry-mixed graphene-PDMS, in this embodiment, the preparation process is improved near the percolation threshold point, because when the mass fraction of the conductive material in the composite nanomaterial is close to the percolation threshold, the conductivity change rate of the composite nanomaterial is the largest; experimental tests have found that on the basis of the percolation threshold with a graphene mass ratio of 11wt%, further adding 1wt% of carbon nanotubes can significantly improve the conductivity of the composite material (0.41S / m), which is much better than continuing to add 1wt% of graphene (1.72×10 -5 S / m), and the elongation at break of the material is increased to about 2 times of the traditional dry mixing method; Figure 5 and 6 As shown, the improvement effect of adding carbon nanotubes near the percolation threshold on the conductivity and elongation at break of the composite material; during the preparation process, the settings of specific material proportion parameters, reaction temperature and stirring parameters are based on the existing process and actual requirements or through multiple experimental comparisons to obtain better process parameters.

[0075] In this embodiment, the 3D printer mainly includes an air pump 9, an air valve 10, a first stepper motor 11, a second stepper motor 12 and a third stepper motor 13; wherein the first stepper motor 11, the second stepper motor 12 and the third stepper motor 13 respectively realize movement in three directions of X, Z and Y, and the specific implementation method adopts the existing technology and conventional settings, which will not be described in detail here.

[0076] In this embodiment, the excitation electric field of the multi-frequency electro-induced arrangement of the composite nanomaterial is optimized: after the nano-composite material 14 is prepared into a sensor by 3D printing, an AC electric field is applied, and the graphene 18 and the carbon nanotubes 19 form a cross-linked conductive network under the action of the electro-induced torque, and the AC electric field is further maintained during the baking and curing process to achieve the curing of the cross-linked network; after the AC electric field is applied, the graphene 18 and the carbon nanotubes 19 rotate to a direction parallel to the electric field under the action of the electro-induced torque, such as Figure 7 , Figure 8 , Fig. 9 , Figure 10 and Fig.11 As shown, graphene 18 and carbon nanotubes 19 form a cross-linked conductive network under the action of an alternating electric field, which are respectively the initial state of the composite nanomaterial prepared by the dry mixing method, wherein the graphene and carbon nanotubes are in a disordered state, after applying an alternating electric field of 10kHz, the graphene is arranged end-to-end under the action of the electromotive force, after applying alternating electric fields of 10kHz and 1kHz at the same time, the graphene and carbon nanotubes are arranged end-to-end, the conductive nanostructure induces a rotational torque in the electric field to generate the initial state of rotation, and the conductive nanostructure induces a rotational torque in the electric field to generate the equilibrium state principle schematic diagram.

[0077] In this embodiment, the circuit for providing the AC electric field mainly includes a function generator 15 , a high voltage amplifier 16 and a protection resistor 17 .

[0078] The above description is only a preferred embodiment of the present embodiment and is not intended to limit the present embodiment. For those skilled in the art, the present embodiment may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present embodiment shall be included in the protection scope of the present embodiment.

Claims

1. Corneal contact tonometer, It is characterized in that It includes a corneal contact lens base, a resonant inductive sensor and a comb-teeth capacitive sensor; The resonant inductance sensor and the comb-teeth capacitance sensor are connected and adhered to the surface of the corneal contact lens base; The corneal contact lens base is a hemispherical shell, the resonant inductance sensor is a ring-shaped tooth structure made of conductive material, and the resonant inductance sensor is concentrically arranged with the corneal contact lens base; the comb-tooth capacitance sensor is a comb-tooth structure made of conductive material, and is arranged on the side of the corneal contact lens base; The corneal contact tonometer is processed by a dry mixing method, which mainly includes three key steps: ultrasonic stirring, 3D printing and electro-alignment baking and curing. Specifically, the following steps are performed: Mixing and preparing a nanocomposite paste; the nanocomposite material includes graphene, carbon nanotubes and polydimethylsiloxane; during mixing, the preparation process is improved near the graphene percolation threshold point, and carbon nanotubes are added; Using a 3D printer, the paste-like nanocomposite material is printed on the contact lens substrate into a preset sensor shape; An AC electric field is applied to the printed sensor using a micro-tungsten needle; graphene and carbon nanotubes form a cross-linked conductive network under the action of electromotive force. Maintaining an AC electric field for baking and curing; Based on the vacuum vapor deposition method, a polyparaxylene protective layer is generated on the sensor surface.

2. The corneal contact tonometer according to claim 1, It is characterized in that During mixing, 1 wt% of carbon nanotubes were added based on the percolation threshold of graphene mass ratio of 11wt%.

3. The corneal contact tonometer according to claim 1, It is characterized in that The comb-teeth capacitance of the comb-teeth capacitance sensor is a parallel connection of multiple capacitors.

4. The corneal contact tonometer according to claim 1, It is characterized in that The conductive material is graphene nanomaterial.

5. Contact lenses, It is characterized in that The invention comprises a spectacles body, an external detection coil connected to the spectacles body, and an independently arranged corneal contact tonometer as described in any one of claims 1 to 4.

6. The contact lens according to claim 5, It is characterized in that The spectacles body is provided with a detection circuit, and the external detection coil is connected with the detection circuit; the external detection coil is arranged concentrically with the corneal contact tonometer.

7. The contact lens according to claim 5, It is characterized in that The external detection coil is a coil composed of grid conductors; the external detection coil is arranged on the convex side of the corneal contact tonometer.

8. How to use contact lenses. It is characterized in that A corneal contact lens as claimed in any one of claims 5 to 7 is used, comprising: The pupil is located in the central blank and unobstructed area of ​​the corneal contact tonometer; the external detection coil is installed on the glasses worn, and the coil wire is staggered from the pupil area.

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