A sample analysis device

Abstract

A sample analysis device, a reagent dispensing component (60) of which has reagent needles (61); each reagent needle (61) is arranged in a manner capable of independent motion; wherein each processing unit (50) is configured with a set of reagent needles (61); the reagent needles (61) are used to suck reagent from a reagent carrying component (40) and discharge into the reaction cup of the corresponding processing unit (50), and each set of reagent needles (61) includes at least two reagent needles (61). Each reagent needle (61) sequentially performs a plurality of preset actions to complete the reagent adding operation, and at least one corresponding preset action in the plurality of preset actions between two reagent needles (61) does not overlap in time sequence.

Description

TECHNICAL FIELD

[0001] The present application relates to a sample analysis device. BACKGROUND

[0002] A sample analysis device, such as a biochemical analyzer, an immunoassay analyzer, a coagulation analyzer, and a cell analyzer, is an instrument for analyzing and measuring a sample, generally by adding a reagent to the sample, and measuring the characteristics, chemical composition, and concentration of the sample itself by a certain method after the sample reacts with the reagent.

[0003] In order to realize automatic testing of the sample analysis device, a core is to decompose a complex measurement process into successive repeatable measurement cycles, each cycle in which each component completes a predetermined one or more actions, and different measurement processes are realized by combination of different measurement cycles.

[0004] With the increasing amount of sample testing, users hope to obtain a sample analysis device with faster testing speed, improve the processing capacity of the sample analysis device for samples, thereby reducing the testing time and obtaining the detection result more quickly. The key to improving the testing speed is to shorten the measurement cycle time as much as possible, that is, to ensure that all components of the instrument can complete all the work required for measurement in the shortest possible time.

[0005] The reagent sample adding and dispensing process is a key link in the measurement process, and how to complete all the required actions in a short time cycle is the key to improving the testing speed of the sample analysis device. How to solve the contradiction between the increasingly short measurement cycle and the time length occupied by the complex actions is the research object of the present application. SUMMARY

[0006] The present application mainly provides a sample analysis device, which is described in detail below.

[0007] According to a first aspect, a sample analysis device is provided in an embodiment, comprising:

[0008] A reaction cup loading component for supplying and carrying empty reaction cups;

[0009] A scheduling component for scheduling reaction cups;

[0010] A sample loading component for scheduling a sample to be loaded to a sample loading position;

[0011] A sample dispensing component for drawing the sample from the sample loading position and discharging it into a reaction cup located at a sample adding position;

[0012] A reagent carrying component having a plurality of positions for carrying reagent containers;

[0013] one or more processing units; the processing units are configured to receive the reaction cup carrying the sample dispatched by the dispatching component and process the sample in the reaction cup;

[0014] a reagent dispensing component having reagent needles; each reagent needle is configured to independently move; wherein each processing unit is configured with a set of reagent needles; the reagent needles are configured to suck reagent from the reagent carrying component and discharge into the reaction cup in the corresponding processing unit, and each set of reagent needles includes at least two reagent needles;

[0015] a cleaning component configured to clean the reagent needles;

[0016] and

[0017] a processor; the processor is configured to control each reagent needle in the same set to sequentially perform a plurality of preset actions to complete the reagent adding operation, and at least one corresponding preset action in the plurality of preset actions between each pair of reagent needles in the same set does not overlap in time sequence.

[0018] According to the second aspect, in an embodiment, a sample analysis device is provided, comprising:

[0019] a reaction cup loading component configured to supply and carry empty reaction cups;

[0020] a dispatching component configured to dispatch the reaction cups;

[0021] a sample loading component configured to dispatch the sample to be loaded to a sample loading position;

[0022] a sample dispensing component configured to suck the sample from the sample loading position and discharge into the reaction cup in the sample adding position;

[0023] a reagent carrying component; the reagent carrying component is in a disc structure and has a plurality of positions for carrying reagent containers; the reagent carrying component is configured to rotate and drive the reagent containers carried thereby to rotate to a reagent sucking position;

[0024] one or more processing units; the processing units are configured to receive the reaction cup carrying the sample dispatched by the dispatching component and process the sample in the reaction cup; wherein each processing unit is configured with a corresponding reagent adding intermediate position; and

[0025] a reagent dispensing component having reagent needles; the reagent needles are configured to suck reagent from the reagent sucking position and discharge into the reaction cup in the reagent adding intermediate position; wherein each reagent adding intermediate position is configured with a set of reagent needles, each set of reagent needles includes at least two reagent needles, and the reagent needles are configured to independently move along a straight line between the reagent sucking position and the corresponding reagent adding intermediate position;

[0026] a plurality of cleaning pools are arranged on the linear motion track of each reagent needle respectively, and used for cleaning the reagent needle;

[0027] a processor; the processor is used for controlling each reagent needle to sequentially perform a reagent suction action, a reagent heating action in the reagent needle, a reagent discharge action and a reagent needle cleaning action to complete the reagent adding operation; the sample analysis device comprises a ping-pong mode, and the processor executes the ping-pong mode to make at least one corresponding action between each two reagent needles in each group of reagent needles not overlap in time sequence.

[0028] According to a third aspect, in one embodiment, a sample analysis device is provided, comprising:

[0029] a reaction cup loading component used for supplying and carrying an empty reaction cup;

[0030] a scheduling component used for scheduling the reaction cup;

[0031] a sample feeding component used for scheduling a sample to be fed to a sample suction position;

[0032] a sample dispensing component used for sucking the sample from the sample suction position and discharging the sample into a reaction cup located at a sample adding position;

[0033] a reagent carrying component having a plurality of positions for carrying reagent containers;

[0034] one or more processing units; the processing units are used for receiving the reaction cup carrying the sample scheduled by the scheduling component and processing the sample in the reaction cup;

[0035] a reagent dispensing component having reagent needles; each reagent needle is arranged in a manner capable of independent motion; each processing unit is configured with a group of reagent needles; the reagent needles are used for sucking reagents from the reagent carrying component and discharging the reagents into the reaction cup of the corresponding processing unit, and each group of reagent needles comprises at least two reagent needles;

[0036] a cleaning component used for cleaning the reagent needles;

[0037] and

[0038] a processor; the processor is used for controlling each reagent needle to sequentially perform a plurality of preset actions to complete the reagent adding operation, and at least one corresponding preset action in the plurality of preset actions between each two reagent needles does not overlap in time sequence. BRIEF DESCRIPTION OF DRAWINGS

[0039] Figure 1 a structural schematic diagram of a sample analysis device according to one embodiment;

[0040] Figure 2 a structural schematic diagram of a sample analysis device according to another embodiment;

[0041] Figure 3 This is a schematic diagram of the sample analysis device according to another embodiment;

[0042] Figures 4(a) and 4(b) are schematic diagrams of the reagent carrier components in two embodiments;

[0043] Figure 5 This is a schematic diagram of the structure of the reagent carrier component according to another embodiment;

[0044] Figure 6 A schematic diagram of the structure of a sample analysis device according to another embodiment;

[0045] Figure 7 This is a schematic diagram of the structure of a reagent dispensing component according to one embodiment;

[0046] Figure 8 This is a schematic diagram of the reagent dispensing component according to another embodiment;

[0047] Figure 9 This is a schematic diagram of the reagent dispensing component according to another embodiment;

[0048] Figure 10 This is a schematic diagram of the structure of a reagent dispensing component according to another embodiment.

[0049] Figure 11 This is a schematic diagram of the sample analysis device according to another embodiment;

[0050] Figure 12(a) is a schematic diagram of the structure of a transfer component according to an embodiment; Figure 12(b) is a schematic diagram of the structure of a first transfer component according to an embodiment; Figure 12(c) is a schematic diagram of the structure of a second transfer component according to an embodiment; and Figure 12(d) is a schematic diagram of the structure of a third transfer component according to an embodiment.

[0051] Figure 13 This is a schematic diagram of the structure of a cup-holding hand according to one embodiment;

[0052] Figure 14 Here is a schematic diagram of the sample analysis device according to another embodiment;

[0053] Figure 15 This is a schematic diagram of the sample analysis device according to yet another embodiment;

[0054] Figure 16 This is a schematic diagram of the structure of a cleaning component according to one embodiment;

[0055] Figure 17 This is a flowchart illustrating a sample analysis method according to one embodiment;

[0056] Figure 18This is a timing diagram of two reagent needles from the same group in one embodiment;

[0057] Figure 19 This is a timing diagram of the two reagent needles in the same group as another embodiment;

[0058] Figure 20 A timing diagram of two reagent needles in the same group as another embodiment;

[0059] Figure 21 This is a timing diagram of the two reagent needles in the same group in another embodiment;

[0060] Figure 22 A method for a sample analysis apparatus according to one embodiment. Detailed Implementation

[0061] The present invention will now be described in further detail with reference to specific embodiments and accompanying drawings. Similar elements in different embodiments are referred to by associated similar element reference numerals. In the following embodiments, many details are described to facilitate a better understanding of the invention. However, those skilled in the art will readily recognize that some features may be omitted in different situations, or may be replaced by other elements, materials, or methods. In some cases, certain operations related to the present invention are not shown or described in the specification. This is to avoid obscuring the core parts of the invention with excessive description. For those skilled in the art, detailed description of these related operations is not necessary; they can fully understand the related operations based on the description in the specification and general technical knowledge in the art.

[0062] Furthermore, the features, operations, or characteristics described in the specification can be combined in any suitable manner to form various embodiments. At the same time, the steps or actions in the method description can be rearranged or adjusted in a manner obvious to those skilled in the art. Therefore, the various orders in the specification and drawings are only for the clear description of a particular embodiment and do not imply a necessary order, unless otherwise stated that a particular order must be followed.

[0063] The serial numbers assigned to components in this document, such as "first" and "second," are used only to distinguish the described objects and have no sequential or technical meaning. The terms "connection" and "linkage" used in this invention, unless otherwise specified, include both direct and indirect connections (linkages).

[0064] The structure of the sample analysis device according to some embodiments of the present invention will be described below.

[0065] A sample analysis device is an instrument used to analyze and measure samples. Let's take a coagulation analyzer as an example to illustrate the testing process of a sample analysis device. The general testing process of a coagulation analyzer is as follows: Samples and reagents are added to a reaction vessel to prepare a reaction solution. After mixing and incubation, the reaction vessel is placed in the measuring unit. The measuring unit irradiates the reaction solution in the reaction vessel with multi-wavelength light, and the coagulation reaction curve of the reaction solution over time is obtained through methods such as coagulation analysis, immunoturbidimetry, or chromogenic substrate analysis. This allows for the calculation of the coagulation time or other coagulation-related performance parameters. Because the coagulation analyzer detects the coagulation reaction curve of the reaction solution over time, the time boundary conditions, such as the sample and reagent addition time and incubation time, need to be strictly set and controlled in the testing process to obtain accurate results.

[0066] Please refer to Figure 1 This is a schematic diagram of the structure of a sample analysis device according to some embodiments of the present invention. The sample analysis device according to some embodiments of the present invention may include a housing 1, a reaction vessel loading component 10, a sample component 20, a sample dispensing component 30, a reagent carrying component 40, one or more reagent dispensing components 60, one or more processing units 50, and a scheduling component 70. It should be noted that... Figure 1 The illustration shows an example with two reagent dispensing units 60 and two processing units 50, but those skilled in the art will understand that this is merely an example and not intended to limit the number of reagent dispensing units 60 and processing units 50 to two. The components of the sample analysis device are described in detail below.

[0067] The housing 1 is the instrument housing of the sample analysis device. For example, it may have a box shape that is basically rectangular or cubic, and its function may be to house some components of the sample analysis device. For example, in some embodiments, the housing 1 includes a first side 1a along a first direction and a second side 1b along a second direction.

[0068] In some embodiments, the first and second directions mentioned herein can be perpendicular, for example, the first direction is the Y direction in the figure and the second direction is the X direction in the figure.

[0069] The reaction vessel loading component 10 is used to supply and transport empty reaction vessels. During operation, the sample analysis device continuously uses empty reaction vessels to complete various tests. The device prepares, incubates, and measures the reaction solution by adding samples and reagents to the empty reaction vessels, thereby obtaining the test results. The reaction vessel loading component 10 can load the empty reaction vessels to a predetermined position, and the sample dispensing mechanism draws samples from the sample component 20 and dispenses them into the empty reaction vessels at the predetermined positions.

[0070] The sample component 20 is used to supply a sample holder that carries the samples to be tested. In some embodiments, the sample component 20 may be disposed within the housing 1. The sample component 20 can be implemented in various ways.

[0071] In one implementation of the sample component 20, the sample component 20 can be a sample injection component, which is used to schedule the sample rack carrying the sample to the sample suction position. Figure 2 For example, the sample introduction component may include a loading area 21a, a sample introduction channel 21b, and an unloading area 21c, wherein a sample suction position may be provided on the sample introduction channel 21b. In the figure, the X and Y directions are perpendicular, the X1 and X2 directions are opposite, and the Y1 and Y2 directions are also opposite. The user can place the sample holder carrying the sample to be tested into the loading area 21a. The loading area 21a moves the sample holder in the Y1 direction to enter the sample introduction channel 21b. The sample holder can move along the X1 direction in the sample introduction channel 21b and pass through the sample suction position. When the sample holder passes through the sample suction position, the sample dispensing component 30 can pick up the sample. The sample holder then enters the unloading area 21c along the Y2 direction from the sample introduction channel 21b. The user can remove the sample holder from the unloading area 21c. The sample introduction component is more suitable for large-scale sample testing, and the sample introduction component can be set independently from the sample analysis device. When the sample analysis device needs to be connected to a pipeline-type testing system, the sample introduction component can be directly removed.

[0072] In another implementation of the sample component 20, the sample component 20 can be a sample placement area, which is used to place a sample holder carrying the sample to be tested. Figure 3 Here's an example. The sample placement area can have multiple channels 22a, each channel 22a can hold one sample holder. The user can push the sample holder into the channel 22a along the Y1 direction in the diagram. The sample dispensing component 30 can sequentially pick up the samples from the sample holders in each channel 22a. After all the samples on the sample holders have been picked up, the user can pull the sample holders out of the channel 22a along the Y2 direction in the diagram. The sample placement area does not require the arrangement of the sample holders, thus occupying a smaller volume, which is beneficial for reducing the size of the sample analysis device and is highly advantageous for the miniaturization design of the sample analysis device.

[0073] The sample dispensing component 30 is used to aspirate a sample from the aspiration position and dispense it into a reaction cup located at the sample loading position. In some embodiments, the sample dispensing component 30 may be housed within the housing 1. In some embodiments, the sample dispensing mechanism 30 may include a sample needle, which is driven by a two-dimensional or three-dimensional drive mechanism to move in a two-dimensional or three-dimensional direction. In some embodiments, there may be one or more sample needles. To simplify the movement trajectory and reduce the volume and size of the sample analysis device, the aspiration position and the predetermined position to which the empty reaction cup is loaded by the reaction cup loading component 10 can be designed to be on a straight line, for example, on a straight line along a first direction. In this way, the sample needle only needs to reciprocate between the aspiration position and the predetermined position in the first direction, which not only increases the movement speed of the sample needle but also helps to reduce the size of the sample analysis device, which is very beneficial for the miniaturization design of the sample analysis device.

[0074] The reagent carrier 40 is used to carry reagents. For example, the reagent carrier 40 may have multiple positions for carrying reagent containers, which in turn carry the reagents. Generally, the reagent carrier 40 can provide cooling or other functions for the carried reagents to ensure their activity. In some embodiments, the reagent carrier 40 may be housed within the housing 1. In some embodiments, the reagent carrier 40 is arranged in a disc-shaped structure and has multiple positions for carrying reagent containers. The reagent carrier 40 can rotate and drive the reagent containers it carries to move, thereby rotating the reagent containers to the reagent aspiration position for the reagent dispensing component 60 to aspirate the reagents. For example, the reagent carrier 40 includes a first driving component for driving its rotation, which drives the reagent carrier 40 to rotate to rotate the reagent containers to the reagent aspiration position. The reagent carrier 40 with a disc-shaped structure will be described in detail below.

[0075] Referring to Figure 4(a), in some specific embodiments, the reagent carrier 40 is arranged in a disc-shaped structure, which has multiple positions for placing reagent cups 41. Each reagent cup 41 includes one or more cavities for holding the reagents required for the test, and one reagent is placed in one cavity. The reagent carrier 40 includes a first driving component for driving its rotation. The first driving component drives the reagent carrier 40 to rotate, so as to rotate the cavity of the reagent cup 41 containing the reagents required for the test to the corresponding reagent aspiration position. In one example, each reagent cup 41 includes at least a first cavity 41a for carrying a first reagent and a second cavity 41b for carrying a second reagent. For example, each reagent cup 41 includes at least a first cavity 41a for carrying a mixed reagent R1 and a second cavity 41b for carrying a trigger reagent R2. The reagent carrying component 40 includes a first reagent suction position and a second reagent suction position different from the first reagent suction position. A first driving component drives the reagent carrying component 40 to rotate and causes the reagent cup 41 to rotate, so as to rotate the first cavity 41a of the reagent cup 41 to the first reagent suction position. The first driving component drives the reagent carrying component 40 to rotate and causes the reagent cup 41 to rotate, so as to rotate the second cavity 41b to the second reagent suction position.

[0076] Referring to Figure 4(b), in some specific embodiments, the reagent carrier 40 is arranged in a disk-shaped structure, having multiple positions for holding first reagent containers 42 for holding first reagents and multiple positions for holding second reagent containers 43 for holding second reagents. The reagent carrier 40 includes a first driving assembly for driving its rotation. The first driving assembly drives the reagent carrier 40 to rotate and causes the first reagent containers 42 to rotate, so as to rotate the first reagent containers 42 to a first reagent aspiration position; the first driving assembly also drives the reagent carrier 40 to rotate and causes the second reagent containers 43 to rotate, so as to rotate the second reagent containers 43 to a second reagent aspiration position. In one example, the reagent carrier 40 may include multiple independently rotatable tracks. For example, the reagent carrier 40 may include two tracks—an inner track and an outer track. Multiple positions for first reagent containers 42 can be set on the outer track, and correspondingly, multiple positions for second reagent containers 43 can be set on the inner track. The inner and outer tracks are driven to rotate independently by the first driving assembly.

[0077] The above describes two types of reagent-carrying components 40. For example, Figure 4(a) shows an example of placing reagent cups 41, and Figure 4(b) shows an example of implementing the reagent-carrying component 40 using multiple independently rotatable tracks. Those skilled in the art will understand that these two methods can also be combined to implement the reagent-carrying component 40 using multiple independently rotatable tracks, with at least one track or multiple positions for placing reagent cups 41 on each track, for example... Figure 5In one example, the reagent carrier 40 may include two tracks—an inner track and an outer track. Multiple positions for placing reagent cups 41 may be set on the outer track, and correspondingly, multiple positions for placing reagent cups 41 may also be set on the inner track. The inner and outer tracks are driven to rotate independently by a first drive assembly.

[0078] The above is a description of the reagent carrier component 40. During its working cycle, the reagent carrier component 40 can rotate to move and dispatch the corresponding reagents required for the test to the corresponding aspiration positions of the reagent dispensing component 60. For example, the first reagent can be dispatched to the first aspiration position, and the second reagent can be dispatched to the second aspiration position.

[0079] The processing unit 50 is used to receive a reaction vessel containing a sample and to process the sample in the reaction vessel. Here, the sample refers to a reaction solution composed of a sample and reagents. There may be one or more processing units 50.

[0080] Please refer to Figure 6 In some embodiments, at least one of the processing units 50 is a reaction component 51 for incubating the sample. The reaction component 51 is used to hold the reaction cup and incubate the sample in the reaction cup. In some embodiments, the reaction component 51 is rectangular and has multiple reaction cup placement positions. Generally, the reaction component 51 can heat the reaction liquid or sample in the reaction cup at each reaction cup placement position to incubate the sample. For example, the sample in the reaction cup can be heated and maintained at 37±0.5°C. The specific heating time and temperature can be determined by the heating parameters corresponding to different test items. In some embodiments, the length direction of the reaction component 51 is arranged along a first direction, such as along the Y direction in the figure.

[0081] In some embodiments, at least one of the processing units 50 is a measuring component 52 for measuring the sample. The measuring component 52 is used to carry the reaction cup and detect the sample in the reaction cup. In some embodiments, the measuring component 52 is rectangular and has multiple reaction cup placement positions. Generally, the measuring component 52 can be configured with a detection part (not shown in the figure) for each reaction cup placement position, and each detection part is used to detect the sample in the reaction cup at the corresponding reaction cup placement position. In some embodiments, the length direction of the measuring component 52 is arranged along a second direction different from the first direction, for example, along the X direction in the figure.

[0082] In some embodiments, the reaction component 51 and the measuring component 52 are arranged adjacently around the reagent carrier component 40. In some specific embodiments, the reaction component 51 and the measuring component 52 are arranged along a first side 1a and a second side 1b, respectively, and are arranged adjacently around the reagent carrier component 40.

[0083] The rectangular reaction component 51 and the measuring component 52 are arranged along the first side 1a and the second side 1b, respectively, and surround the reagent carrier component 40 in an adjacent manner. This can save space, reduce the size of the sample analysis device, and also facilitate the interaction between the reagent carrier component 40 and the reaction component 51 and the measuring component 52 through the reagent dispensing component 60.

[0084] In some embodiments, the sample component 20, such as the sample injection component, the reaction vessel loading component 10, the reaction component 51, and the determination component 52, are arranged around the reagent carrier component 40. This application centers on the reagent carrier component 40 and designs the entire detection process trajectory of the reaction vessel around it, resulting in a novel and space-saving design.

[0085] Each processing unit 50 can be configured with a corresponding reagent transfer station. For example, the reaction component 51 is configured with at least one incubation transfer station 51a for placing a reaction cup. The number of incubation transfer stations 51a can be one or more. When the position for placing a reaction cup at the incubation transfer station 51a is set to one, the incubation transfer station 51a can be configured to be position-adjustable so that the reaction cup placed on the incubation transfer station 51a can be positionally aligned with each reagent needle in the first reagent dispensing component (the first reagent dispensing component corresponds to the reaction component and adds reagent to the reaction cup in the reaction component) to receive the reagent dispensed by each reagent needle. In some embodiments, the incubation transfer station 51a is located between the reagent carrying component 40 and the reaction component 51. The measuring component 52 is configured with at least one measuring transfer station 52a for placing a reaction cup. The number of measuring transfer stations 52a can be one or more. In some embodiments, the measuring transfer station 52a is located between the reagent carrying component 40 and the measuring component 52. When the position of the reaction cup placed at the measuring transducer 52a is set to one, the measuring transducer 52a can be set to an adjustable position so that the reaction cup placed on the measuring transducer 52a can be positioned to correspond with each reagent needle in the second reagent dispensing component (the second reagent dispensing component corresponds to the measuring component and adds reagent to the reaction cup in the measuring component) so as to receive the reagent dispensed by each reagent needle.

[0086] Figure 6 The diagram shows that there is one incubation transposition 51a, and each incubation transposition 51a has two positions for placing reaction cups, such as the first position and the second position for placing reaction cups; there is one measurement transposition 52a, and each measurement transposition 52a has two positions for placing reaction cups, such as the third position and the fourth position for placing reaction cups.

[0087] The reagent dispensing component 60 is used to draw reagents from the reagent aspiration position and dispense them into the reaction vessel at the reagent addition position. For example, the reagent dispensing component 60 can draw a first reagent from the first reagent aspiration position mentioned herein and dispense it into the reaction vessel; the reagent dispensing component 60 can draw a second reagent from the second reagent position mentioned herein and dispense it into the reaction vessel. In some embodiments, the reagent dispensing component 60 may be disposed within the housing 1.

[0088] The reagent dispensing component 60 can be implemented by a reagent needle. Therefore, in some embodiments, the reagent dispensing component 60 includes a reagent needle for drawing reagents from the reagent carrying component 40 and dispensing them into a reaction vessel.

[0089] In terms of the number of reagent needles, in some embodiments, the reagent dispensing component 60 may have multiple reagent needles, each arranged in a manner that allows it to move independently of the others. Specifically, the reagent needles can be configured such that each processing unit 50 is equipped with a set of reagent needles; the reagent needles are used to draw reagents from the reagent carrying component 40 and dispense them into the reaction cup of the corresponding processing unit 50, and each set of reagent needles includes at least two reagent needles. For example, a set of reagent needles can be configured for the reaction component 51, and a set of reagent needles can be configured for the measuring component 52. In some specific embodiments, a first set of reagent needles can be configured for the reaction component 51. The first set of reagent needles is arranged to move linearly between the reagent aspiration position and the incubation transposition position 51a. The first set of reagent needles is used to draw reagent from the reagent aspiration position and discharge it into the reaction cup located at the incubation transposition position 51a. The first set of reagent needles includes at least one reagent needle. Similarly, a second set of reagent needles can be configured for the measuring component 52. The second set of reagent needles is arranged to move linearly between the reagent aspiration position and the measuring transposition position 52a. The second set of reagent needles is used to draw reagent from the reagent aspiration position and discharge it into the reaction cup located at the measuring transposition position 52a. The second set of reagent needles includes at least one reagent needle.

[0090] In terms of the number of reagent dispensing components 60, in some embodiments, the number of reagent dispensing components 60 is equal to the number of processing units 50, and one reagent dispensing component 60 corresponds to one processing unit 50. (The above text is incomplete and requires further context.) Figures 1 to 3 These are all examples of this. Specifically, there could be two reagent dispensing units 60, with one reagent dispensing unit 60 corresponding to the reaction unit 51 and the other reagent dispensing unit 60 corresponding to the measurement unit 52. By configuring one reagent dispensing unit 60 for each processing unit 50, the reagent addition process for the detection item is broken down. That is, each reagent dispensing unit 60 only needs to add the corresponding reagent to the reaction cup of the corresponding processing unit 50. This allows the addition of the corresponding reagents for the detection item to be completed by division of labor, which helps to improve efficiency.

[0091] The specific structure of the reagent dispensing component 60 is described below.

[0092] Please refer to Figure 7 Each reagent dispensing unit 60 includes multiple reagent needles 61, a guide assembly 62 for guiding the multiple reagent needles 61 in a linear motion, and a second drive assembly 63 for driving the multiple reagent needles 61 in a linear motion along the guide assembly 62. The guide assembly 62 is arranged along the direction determined by the reagent aspiration position and the reagent addition intermediate position of the corresponding processing unit 50 of the reagent dispensing unit 60, so that the reagent needles 61 aspirate reagent from the reagent aspiration position and discharge it into the reaction cup of the reagent addition intermediate position of the processing unit 50 corresponding to the reagent dispensing unit 60. For example Figure 7 The reagent dispensing component 60 on the left side of the middle has a guiding component 62 arranged in the direction determined by the reagent aspiration position and the incubation transition position 51a of the reaction component 51, so that the reagent needle 61 of the reagent dispensing component 60 draws the reagent from the reagent aspiration position and discharges it into the reaction cup located at the incubation transition position 51a. Figure 7 The reagent dispensing component 60, located on the right side of the center, has its guiding component 62 positioned along the direction determined by the reagent aspiration position and the measurement intermediate position 52a of the measuring component 52. This allows the reagent needle 61 of the reagent dispensing component 60 to draw reagent from the reagent aspiration position and discharge it into the reaction cup located at the measurement intermediate position 52a. In some embodiments, the number of second driving components 63 in each reagent dispensing component 60 is equal to the number of reagent needles 61. The independent driving force output terminals of the multiple second driving components 63 act on multiple reagent needles 61 respectively, so as to independently drive the multiple reagent needles 61 to move linearly along the guiding component 62 between the reagent aspiration position and the reagent dispensing intermediate position. For example... Figure 7 The example shown is an example where each reagent dispensing component 60 includes two reagent needles 61, each of which is independently driven by its own second drive assembly 63.

[0093] There are several ways to implement the guide component 62; a few examples are given below.

[0094] Figure 8This is a schematic diagram of the side of the reagent dispensing component 60. In some embodiments, the guide assembly 62 of each reagent dispensing component 60 includes: a crossbeam 62a and a plurality of parallel guide members 62b arranged along the length of the crossbeam 62a; the crossbeam 62a is arranged along the direction determined by the reagent aspiration position and the reagent addition transfer position of the corresponding processing unit 50 of the reagent dispensing component 60; the number of guide members 62b is equal to the number of reagent needles 61 of the reagent dispensing component 60, and the plurality of reagent needles 61 are slidably connected to the plurality of guide members 62b, so that the reagent needles 61 move linearly along the guide members 62b between the reagent aspiration position and the reagent addition transfer position. In some embodiments, each reagent dispensing component 60 has two reagent needles 61; each reagent dispensing component 60 has two guide members 62b, and both guide members 62b are linear guides; these two linear guides are respectively arranged on both sides of the crossbeam 62a along the long axis of the crossbeam 62a. Figure 8 The diagram shown is a schematic of one side of the crossbeam 62a, and the structure on the other side exposes a reagent needle 61; the two reagent needles 61 are respectively set on the linear guide rails on both sides of the crossbeam 62a and are slidably connected to the linear guide rails; the reagent needle 61 moves linearly between the reagent aspiration position and the reagent addition position along the linear guide rails it is located on.

[0095] This is an implementation method that uses a reagent dispensing component with a reagent needle on each side of a crossbeam. In other embodiments, a reagent dispensing component can also be implemented using two parallel crossbeams, each with only one reagent needle, as described below.

[0096] Please refer to Figure 9 and Figure 10 In some embodiments, the guide assembly 62 of each reagent dispensing component 60 includes: multiple parallel crossbeams 62a, and multiple guide members 62b respectively disposed on the multiple crossbeams 62a and disposed along the length direction of the crossbeams 62a; the multiple crossbeams 62a are disposed along the direction determined by the reagent aspiration position and the reagent addition transfer position of the corresponding processing unit 50 of the reagent dispensing component 60; the number of guide members 62b is equal to the number of reagent needles 61 of the reagent dispensing component 60, and the multiple reagent needles 61 are slidably connected to the multiple guide members 62b respectively, so that the reagent needles 61 move linearly along the guide members 62b between the reagent aspiration position and the reagent addition transfer position. In some embodiments, the multiple guides 62b of each reagent dispensing component 60 are linear guides, and the multiple linear guides are respectively arranged along the long axis direction of multiple crossbeams 62a; multiple reagent needles 61 are respectively arranged on the linear guides of the multiple crossbeams 62a and are slidably connected to the linear guides; the reagent needles 61 move linearly between the reagent aspiration position and the reagent dispensing position along the linear guides they are located on.

[0097] In some embodiments, the crossbeam 62a of the guide assembly 62 in each reagent dispensing component 60 is fixedly disposed above the reagent aspiration position and the reagent transfer position of the corresponding processing unit 50 of the reagent dispensing component 60.

[0098] The reagent dispensing component 60, which uses a beam structure to achieve multi-needle linear motion, ensures that the movement trajectory of the reagent needles 61 does not occupy too much space and minimizes interference with the layout of other components. This allows for a more compact structure of the sample analysis device, which is highly beneficial for the miniaturization design of the sample analysis device.

[0099] In some embodiments, the reagent needles 61 of different reagent dispensing components 60 do not intersect each other along their linear motion trajectories. This prevents the movement of the reagent needles 61 of different reagent dispensing components 60 from interfering with each other, which is beneficial for improving the testing speed.

[0100] In some embodiments, at least one processing unit 50 includes reaction cup placement positions that are the same number of reagent needles 61 as the reagent dispensing component 60 corresponding to that processing unit 50. For example Figure 6 In the example shown, the reagent addition transposition site of the reaction component 51 is the incubation transposition site 51a in the figure, which can hold two reaction cups; the reagent dispensing component 60 corresponding to the reaction component 51 has two reagent needles 61. Figure 6 In the figure, the reagent transfer position 52a of the measuring component 52 is the measuring transfer position 52a, which can hold two reaction cups; the reagent dispensing component 60 corresponding to the measuring component 52 has two reagent needles 61. In some embodiments, the number of reagent aspiration positions is the same as the number of reagent needles. For example... Figure 6 The test has two reagent dispensing units 60, each with two reagent needles 61, resulting in four reagent aspiration positions. The number of reagent needles is the same as the number of reagent application positions, allowing each needle to clearly define its function and add reagent to the reaction vessel at its respective application position, thus improving testing speed.

[0101] In some embodiments, the reagent needles 61 in the same reagent dispensing component 60 are used to aspirate the same type of reagent. For example, the reagent needles 61 of the reagent dispensing component 60 corresponding to the reaction component 51 are all used to aspirate the first reagent, and the reagent needles 61 of the reagent dispensing component 60 corresponding to the measuring component 52 are all used to aspirate the second reagent. Different reagent dispensing components 60 are used to aspirate different reagents, which makes the division of labor among the reagent dispensing components 60 clear and helps to improve the testing speed.

[0102] In some embodiments, each reagent needle 61 of the reagent dispensing unit 60 is equipped with a heating element (not shown in the figure) for heating the reagent drawn up by the reagent needle. Since each reagent dispensing unit 60 includes multiple reagent needles 61, let's take two reagent needles as an example. Each reagent needle 61 is also equipped with a heating element. Because there are two reagent needles 61, while maintaining the original speed, each reagent needle 61 has sufficient time—for example, twice the time—to heat the drawn-up reagent. This ensures that when the reagent reaches the corresponding processing unit 50, the temperature of the reagent is already close to the predetermined temperature, meaning the reagent has been sufficiently preheated.

[0103] The above is a brief description of the reagent dispensing component 60. Below, we will take two processing units 50, specifically a reaction unit 51 and a measuring unit 52, as an example to illustrate the cooperation relationship and corresponding structure between the reagent dispensing component 60 and the processing unit 50.

[0104] In some embodiments, the reagent dispensing component 60 corresponding to the reaction component 51 is a first reagent dispensing component, and the reagent dispensing component 60 corresponding to the measuring component 52 is a second reagent dispensing component, as will be described in detail below.

[0105] In some embodiments, the first reagent dispensing component 60 includes a first crossbeam 62a and a first set of reagent needles. The first set of reagent needles includes at least a plurality of first reagent needles 61, such as two needles. These plurality of first reagent needles 61 are disposed on the first crossbeam 62a and move linearly along the long axis of the first crossbeam 62a to draw first reagent from the first reagent adsorption position and discharge it into the reaction cup located at the incubation transfer position 51a. In some embodiments, the first crossbeam 62a is arranged along the direction determined by the first reagent adsorption position and the incubation transfer position 51a, and the first crossbeam 62a is fixedly disposed above the corresponding positions of the first reagent adsorption position and the incubation transfer position 51a.

[0106] In some embodiments, the first crossbeam 62a of the first reagent dispensing component 60 is configured as a single beam, on which the aforementioned multiple first reagent needles 61 are arranged in parallel and move linearly along the long axis of the first crossbeam 62a. Taking a first group of reagent needles having two first reagent needles 61 as an example, a linear guide rail is respectively provided on both sides of the first crossbeam 62a along its long axis, and the two first reagent needles 61 are respectively provided on the linear guide rails on both sides of the first crossbeam 62a. The first reagent needles 61 move linearly between the first reagent aspiration position and the incubation transfer position 51a along their respective linear guide rails. This is an implementation method of the first reagent dispensing component by providing a first reagent needle on each side of a single first crossbeam.

[0107] In some embodiments, the number of first crossbeams 62a in the first reagent dispensing component 60 is equal to the number of multiple first reagent needles 61 in the first group of reagent needles. Each of the aforementioned first crossbeams 62a is provided with one first reagent needle 61, and the first crossbeams 62a are arranged parallel to each other in pairs. In some specific embodiments, each of the multiple first crossbeams 62a is provided with a linear guide rail along its long axis, and the multiple first reagent needles 61 are respectively provided on the linear guide rails of the multiple first crossbeams 62a, so that the first reagent needles 61 can move linearly between the first reagent aspiration position and the incubation transfer position 51a. This is an implementation method of the first reagent dispensing component by using multiple, for example, two parallel first crossbeams, with only one first reagent needle provided on each first crossbeam.

[0108] In some embodiments, the first reagent dispensing component 60 further includes multiple independent driving mechanisms that drive multiple first reagent needles to move linearly, such as second driving components. The number of multiple second driving components is equal to the number of multiple first reagent needles, and the independent driving force output ends of the multiple second driving components act on the multiple first reagent needles to drive the multiple first reagent needles to move linearly between the first reagent aspiration position and the incubation rotation position 51a along the long axis of the first crossbeam.

[0109] Taking the incubation transposition 51a mentioned above as an example, which includes a first position and a second position for placing the reaction cup, in the example where the first reagent dispensing component 60 has two first reagent needles 61, one of the first reagent needles 61 moves linearly along the first crossbeam 62a between the first reagent aspiration position and the first position, and the other first reagent needle 61 moves linearly along the first crossbeam 62a between the first reagent aspiration position and the second position.

[0110] In some embodiments, the first reagent dispensing component 60 further includes a first Z-axis driving assembly 64 for driving the first reagent needles 61 in the first group of reagent needles to move vertically. The number of first Z-axis driving assemblies 64 is the same as the number of first reagent needles 61 in the first group of reagent needles. Each first Z-axis driving assembly 64 includes a first Z-axis guide 64a for guiding the first reagent needle 61 to move vertically, and a first Z-axis driving member 64b for driving the first reagent needle to move along the first Z-axis guide. The first reagent needle 61 is slidably connected to the first crossbeam 62a through the first Z-axis guide 64a and the first Z-axis driving member 64b, so that the first reagent needle 61 can move vertically relative to the first crossbeam 62a under the drive of the first Z-axis driving member 64b. Those skilled in the art will understand that when the reagent needle is performing reciprocating linear motion, it needs to move vertically when it reaches each position to complete operations such as reagent aspiration and reagent dispensing.

[0111] In some embodiments, the first reagent needle 61 may also be provided with a heating element (not shown in the figure) for heating the reagent it has drawn.

[0112] The above is a description of the first reagent dispensing component 60. The second reagent dispensing component 60 will be described below.

[0113] The second reagent dispensing component 60 includes a second crossbeam 62a and a second set of reagent needles. The second set of reagent needles includes at least a plurality of second reagent needles 61, for example, two needles. These plurality of second reagent needles 61 are disposed on the second crossbeam 62a and move linearly along the long axis of the second crossbeam 62a to draw the second reagent from the second reagent absorption position and discharge it into the reaction cup located at the measurement transfer position 52a. In some embodiments, the second crossbeam 62a is arranged along the direction determined by the second reagent absorption position and the measurement transfer position 52a, and the second crossbeam 62a is fixedly disposed above the corresponding positions of the second reagent absorption position and the measurement transfer position 52a.

[0114] In some embodiments, the second crossbeam 62a of the second reagent dispensing component 60 is configured as a single beam, on which the aforementioned multiple second reagent needles 61 are arranged in parallel and move linearly along the long axis of the second crossbeam 62a. Taking a second group of reagent needles having two first reagent needles 61 as an example, a linear guide rail is provided on each side of the second crossbeam 62a along its long axis. The two second reagent needles 61 are respectively positioned on the linear guide rails on both sides of the second crossbeam 62a, and move linearly between the second reagent aspiration position and the measurement intermediate position 52a along their respective linear guide rails. This is an implementation method of the second reagent dispensing component by providing a second reagent needle on each side of a single second crossbeam.

[0115] In some embodiments, the number of second crossbeams 62a in the second reagent dispensing component 60 is equal to the number of multiple second reagent needles 61 in the second group of reagent needles. Each of the aforementioned second crossbeams 62a is provided with one second reagent needle 61, and the two aforementioned second crossbeams 62a are arranged parallel to each other. In some specific embodiments, each of the multiple second crossbeams 62a is provided with a linear guide rail along its long axis, and the multiple second reagent needles 61 are respectively provided on the linear guide rails of the multiple second crossbeams 62a, so that the second reagent needles 61 can move linearly between the second reagent aspiration position and the measurement intermediate rotation position 52a. This is an implementation method of the second reagent dispensing component by using multiple, for example, two parallel second crossbeams, with only one second reagent needle provided on each second crossbeam.

[0116] In some embodiments, the second reagent dispensing component 60 further includes multiple drive mechanisms, different from the second drive assembly and independently driving multiple second reagent needles to perform linear motion. For example, a third drive assembly may be included, the number of which is equal to the number of the multiple second reagent needles. Each of the multiple third drive assemblies has an independent drive force output end that acts on the multiple second reagent needles to drive them to perform linear motion along the long axis of the second beam between the second reagent position and the measurement inversion position. The second drive assembly and the third drive assembly may have the same structure.

[0117] Taking the determination of the intermediate position 52a above, which includes the third and fourth positions for placing the reaction cup, as an example, in the example where the second reagent dispensing component 60 has two second reagent needles 61, one of the second reagent needles 61 moves linearly along the second crossbeam 62a between the second reagent position and the third position, and the other second reagent needle 61 moves linearly along the second crossbeam 62a between the second reagent position and the fourth position.

[0118] In some embodiments, the second reagent dispensing component 60 further includes a second Z-axis driving assembly 64 for driving the second reagent needles 61 in the second group of reagent needles to move in the vertical direction. The number of second Z-axis driving assemblies 64 is the same as the number of second reagent needles 61 in the second group of reagent needles. Each second Z-axis driving assembly 64 includes a second Z-axis guide 64a for guiding the second reagent needle 61 to move in the vertical direction, and a second Z-axis driving member 64b for driving the second reagent needle 61 to move along the second Z-axis guide 64a. The second reagent needle 61 is slidably connected to the second crossbeam 62a through the second Z-axis guide 64a and the second Z-axis driving member 64b, so that the second reagent needle 61 can move in the vertical direction relative to the second crossbeam 62a under the drive of the second Z-axis driving member 64b.

[0119] In some embodiments, the second reagent needle 61 may also be provided with a heating element (not shown in the figure) for heating the reagent it draws.

[0120] In some embodiments, the linear motion trajectory of the multiple first reagent needles 61 of the first reagent dispensing component 60 between the first reagent aspiration position and the incubation transposition position 51a is the first motion trajectory; the linear motion trajectory of the multiple second reagent needles 61 of the second reagent dispensing component 60 between the second reagent aspiration position and the measurement transposition position 52a is the second motion trajectory; wherein the first motion trajectory and the second motion trajectory do not intersect.

[0121] The first reagent dispensing component 60 and the second reagent dispensing component 60 can have the same structure, but they are set in different directions. The first reagent dispensing component 60 is set towards the reaction component 51 and is used to cooperate with the reaction component 51. The second reagent dispensing component 60 is set towards the measuring component 52 and is used to cooperate with the measuring component 52.

[0122] The above is a description of the reagent dispensing component 60. The reagent dispensing component 60, through its beam-type structure, allows the reagent needle 61 to continuously reciprocate linearly between the reagent aspiration position of the reagent carrying component 40 and the reagent dispensing position of the corresponding processing unit, thus completing the aspiration and dispensing of the corresponding reagent.

[0123] The different reagent dispensing components 60 move independently and do not interfere with each other, thus playing a significant role in miniaturizing the instrument and improving the testing speed.

[0124] The scheduling unit 70 is used to schedule reaction cups. For example, the scheduling unit 70 schedules reaction cups that have completed sample addition at the sample addition position to each processing unit 50 according to the detection process. For example, the scheduling unit 70 schedules reaction cups that have had reagent, such as the first reagent, added at the transposition position 51a during incubation to the reaction unit 51, and schedules reaction cups that have had reagent, such as the second reagent, added at the transposition position 52a during measurement to the measurement unit 52. The specific structure of the scheduling unit 70 will be described below.

[0125] Please refer to Figure 11In some embodiments, the scheduling component 70 includes a first transfer component 71, a second transfer component 73, and a third transfer component 75. To coordinate with these three transfer components 71, 73, and 75, in some embodiments, the sample analysis device also includes a first buffer transfer position 77 and a second buffer transfer position 78. In some embodiments, the first buffer transfer position 77 can adopt a fixed buffer position design, having only one reaction cup placement position, i.e., it can only hold one reaction cup, which helps to reduce the volume and size of the sample analysis device. Similarly, the first buffer transfer position 78 can adopt a fixed buffer position design, having only one reaction cup placement position, i.e., it can only hold one reaction cup, which helps to reduce the volume and size of the sample analysis device. Of course, in some embodiments, when the first buffer transfer position 77 and the second buffer transfer position 78 adopt a fixed buffer position design, they can also be designed to have multiple reaction cup placement positions, thereby providing more reaction cup placement positions for scheduling. Furthermore, in some embodiments, the first buffer transfer position 77 can be designed as a movable or rotatable buffer position. For example, the first buffer transfer position 77 may include a reaction cup placement position that can be driven to move or rotate. Thus, during the process of the first transfer member 71 transferring the reaction cup to the first buffer transfer position 77, the first buffer transfer position 77 can also be controlled to move or rotate to a predetermined position to receive the reaction cup transferred by the first transfer member 71. Additionally, when the second transfer member 73 needs to transfer the reaction cup from the first buffer transfer position 77, the first buffer transfer position 77 can also be controlled to move or rotate to a predetermined position so that the second transfer member 73 can more quickly grasp the reaction cup from the first buffer transfer position 77. Similarly, the second buffer... The transposition position 78 may include a reaction cup placement position that can be driven to move or rotate. Thus, during the process of the second transfer member 73 transferring the reaction cup to the second buffer transposition position 78, the second buffer transposition position 78 can also be controlled to move or rotate to a predetermined position to receive the reaction cup transferred by the second transfer member 73. In addition, when the third transfer member 73 needs to transfer the reaction cup on the second buffer transposition position 78, the second buffer transposition position 78 can also be controlled to move or rotate to a predetermined position so that the third transfer member 75 can more quickly pick up the reaction cup on the second buffer transposition position 78. Through this design, the entire transfer process of the reaction cup can be made faster and less time-consuming, improving the efficiency and testing speed of the sample analysis device.

[0126] There are various ways to implement the first transfer component 71, the second transfer component 73, and the third transfer component 75. For example, a guide rail type transfer component can be used, where the reaction cup is placed on a guide rail to transfer the reaction cup; another example is a turntable type transfer component, where the reaction cup is placed on a turntable structure and the turntable itself is used to transfer the reaction cup to the corresponding position; for example, the first transfer component 71, the second transfer component 73, and the third transfer component 75 can be implemented by using a two-dimensional or three-dimensional drive mechanism to drive the cup gripper. The cup gripper grasps the reaction cup, and then the two-dimensional or three-dimensional drive mechanism drives the cup gripper to move, thereby transferring the reaction cup to the corresponding position. The following will describe the method of implementing the transfer component using a cup gripper.

[0127] Referring to Figure 12(a), the first transfer component 71, the second transfer component 73, and the third transfer component 75 all include a cup gripper 79 and a drive component for moving the cup gripper 79. In some embodiments, the cup gripper 79 is used to hold the reaction cup, for example... Figure 13 This is a structural diagram of the cup gripper 79. The opening and closing of the cup gripper 79 can be achieved by a drive mechanism and a spring. The cup gripper 79 can be opened by its drive mechanism. When the drive mechanism is not activated, the cup gripper 79 automatically closes and clamps the object it holds, such as a reaction cup, through its spring. In some examples, a ring of protrusions can be provided on the reaction cup to accommodate the gripper's clamping.

[0128] The following describes each transfer component and its function.

[0129] The first transfer component 71 is used to transport the sample-added reaction cup to the first buffer transfer position 77. In some embodiments, the first transfer component 71 moves linearly along a first direction, such as the Y direction in the figure, to transport the sample-added reaction cup to the first buffer transfer position 77. Since the first transfer component 71 moves the reaction cup in a straight line, the volume of the sample analysis device occupied during the transport of the reaction cup is relatively reduced, which is beneficial to the miniaturization design of the sample analysis device.

[0130] Please refer to Figure 14In some embodiments, the sample analysis device may also include a sample loading position 10a, a pre-dilution position 10b, a first cup-discarding position 10c, and a second cup-discarding position 10d. In some embodiments, the first transfer component 71 may move along a first direction, such as the Y direction in the figure, between the sample loading position 10a, the pre-dilution position 10b, the first cup-discarding position 10c, and the first buffer transfer position 77. The sample loading position 10a may be a predetermined position where the reaction cup loading component 10 mentioned above loads an empty reaction cup. Generally, the sample dispensing component 30 draws a sample from the aspiration position and dispenses it into the reaction cup located at the sample loading position 10a to complete the sample loading. In some cases, samples need to be pre-diluted. In such cases, the first transfer unit 71 first transfers the empty reaction cup on the sample loading position 10a to the pre-dilution position 10b. The sample dispensing unit 30 draws the sample from the aspiration position and dispenses it into the reaction cup located in the pre-dilution position 10b. Then, the sample in the reaction cup of the pre-dilution position 10b is diluted. During this process, the reaction cup loading unit 10 loads a new empty reaction cup onto the sample loading position 10a. Then, the sample dispensing unit 30 draws the pre-diluted sample from the reaction cup on the pre-dilution position 10b and dispenses it into the sample loading position 10a, thus completing the sample loading. The first transfer unit 71 then performs a cup-discarding process on the reaction cup on the pre-dilution position 10b, for example, by transferring it to the first cup-discarding position 10c for cup-discarding.

[0131] As described above, in some embodiments, the first transfer component 71 only needs to move along the first direction. Therefore, the driving component of the first transfer component 71 can be a two-dimensional driving component for driving the cup-gripping hand 79 of the first transfer component 71 to move along the first direction and the vertical direction. The first direction can be the Y direction in the figure, and the vertical direction is the direction perpendicular to the paper in the figure. Referring to Figure 12(b), in some embodiments, the first transfer component 71 includes a first direction guide 71a, a first direction driving component 71b, a vertical direction guide 71c, and a vertical direction driving component 71d. The cup-gripping hand 79 of the first transfer component 71 is slidably disposed on the vertical direction guide 71c, and the cup-gripping hand 79 can move vertically along the vertical direction guide 71c by driving the vertical direction guide 71c. The vertical direction guide 71c is slidably disposed on the first direction guide 71a, and the vertical direction guide 71c can move in the first direction along the first direction guide 71a by driving the first direction driving component 71b, thereby driving the cup-gripping hand 79 of the first transfer component 71 to move in the first direction as well. With this structure, the cup-gripping hand 79 of the first transfer component 71 can move in both the first direction and the vertical direction. In some specific embodiments, the first directional guide 71a may include a first guide rail; the first directional drive component 71b may include a first stepper motor, a first driven wheel, and a first synchronous belt, with the first synchronous belt sleeved between the first stepper motor and the first driven wheel; the vertical directional guide 71c may be fixedly connected to the first synchronous belt; similarly, the vertical directional guide 71c may include a vertical guide rail; the vertical directional drive component 71d may include a lifting stepper motor and a vertical lead screw, with a mounting plate threaded onto the vertical lead screw for mounting the cup gripper 79 of the first transfer component 71. In some embodiments, the first transfer component 71 may also include a first bracket 71f for mounting the aforementioned first directional guide 71a.

[0132] In some embodiments, the gripper 79 of the first transfer component 71 grips the reaction cup, for example, on the sample dispensing position 10a, along a second direction, such as the X direction in the figure. In this way, the first transfer component 71 does not affect the sample dispensing component 30 dispensing the sample into the reaction cup when gripping the reaction cup. This allows the sample dispensing component 30 to complete the sample dispensing of the reaction cup while the first transfer component 71 grips the reaction cup, saving time and improving measurement speed and efficiency.

[0133] The above is a brief description of the first transfer component 71.

[0134] The second transfer component 73 is used to transport the reaction cups from the first buffer transfer position 77 to the reaction unit 51, and to transport the reaction cups from the reaction unit 51 where the sample has been incubated to the second buffer transfer position 78. In some embodiments, the second transfer component 73 transports the reaction cups from the first buffer transfer position 77 to the reaction unit 51, and the reaction cups from the reaction unit 51 where the sample has been incubated, to the second buffer transfer position 78 by linear movement along a first direction, such as the direction shown in the figure, and a second direction, such as the X direction shown in the figure. Since the second transfer component 73 moves the reaction cups in a linear motion, the volume of the sample analysis device occupied during the transport of the reaction cups is relatively reduced, which is beneficial to the miniaturization design of the sample analysis device.

[0135] In the specific transfer process, the second transfer component 73 can first transport the reaction cup in the first buffer transfer position 77 to the incubation transfer position 51a. The reagent dispensing component 60 absorbs the reagent and discharges it into the reaction cup located in the incubation transfer position 51a. The second transfer component 73 then transports the reaction cup in the incubation transfer position 51a to the reaction component 51.

[0136] In some embodiments, the second transfer component 73 can move along a first direction (e.g., the Y direction in the figure), a second direction (e.g., the X direction in the figure), and a vertical direction (e.g., the direction perpendicular to the drawing). Therefore, the driving component of the second transfer component 73 can be a three-dimensional driving component for driving the cup-gripping hand 79 of the second transfer component 73 to move along the first direction, the second direction, and the vertical direction. Referring to Figure 12(c), in some embodiments, the second transfer component 73 includes a first direction guide 73a, a first direction driving component 73b, a second direction guide 73c, a second direction driving component 73d, a vertical direction guide 73e, and a vertical direction driving component 73f. A cup-gripping hand 79 of the second transfer component 73 is slidably disposed on the vertical direction guide 73e, and driven by the vertical direction guide 73f, the cup-gripping hand 79 can move vertically along the vertical direction guide 73e. A vertical direction guide 73e is slidably disposed on the second direction guide 73c, and driven by the second direction driving component 73d, the vertical direction guide 73e can move in the second direction along the second direction guide 73c, thereby driving... The cup-gripping hand 79 of the second transfer component 73 also moves along the second direction; a second direction guide 73c is slidably disposed on the first direction guide 73a, and driven by the first direction driving component 73b, the second direction guide 73c can move along the first direction guide 73a in the first direction, thereby driving the second direction guide 73c to move along the first direction, thereby driving the vertical direction guide 73e on the second direction guide 73c to move in the first direction, thereby driving the cup-gripping hand 79 of the second transfer component 73 on the vertical direction guide 73e to move along the first direction; with this structure, the cup-gripping hand 79 of the second transfer component 73 can move in the three-dimensional directions of the first direction, the second direction and the vertical direction. In some specific embodiments, the first directional guide 73a may include a first guide rail; the first directional drive component 73b may include a first stepper motor, a first driven wheel, and a first synchronous belt, with the first synchronous belt sleeved between the first stepper motor and the first driven wheel, and the second directional guide 73c may be fixedly connected to the first synchronous belt; similarly, the second directional guide 73c may include a second guide rail; the second directional drive component 73d may include a second stepper motor, a second driven wheel, and a second synchronous belt, with the second synchronous belt sleeved between the second stepper motor and the second driven wheel, and the vertical directional guide 73e may be fixedly connected to the second synchronous belt; similarly, the vertical directional guide 73e may include a vertical guide rail; the vertical directional drive component 73f may include a lifting stepper motor and a vertical lead screw, with a mounting plate threaded onto the vertical lead screw for mounting the cup gripper 79 of the second transfer component 73. In some embodiments, the second transfer component 73 may also include a second bracket 73g for mounting the aforementioned first directional guide 73a.

[0137] In some embodiments, the gripper 79 of the second transfer component 73 grips the reaction cup along a second direction, such as the X direction in the figure. This ensures that the second transfer component 73's gripping of the reaction cup does not interfere with the reagent dispensing component 60 (e.g., the first reagent dispensing component) adding reagent to the reaction cup. This allows the reagent dispensing component 60 to add reagent to the reaction cup simultaneously with the second transfer component 73's gripping, saving time and improving measurement speed and efficiency. In some embodiments, the direction in which the second transfer component 73 grips the reaction cup is greater than 90 degrees from the direction of linear movement of the first set of reagent needles. This further reduces the likelihood of conflict between the second transfer component 73's gripping of the reaction cup and the reagent dispensing action of the first set of reagent needles, allowing them to perform their respective actions independently and in parallel in a very reasonable manner.

[0138] In some embodiments, the second transfer component 73 mixes the sample in the reaction cup while transporting it from the incubation transfer position 51a to the reaction component 51. For example, after the second transfer component 73 transfers the reaction cup with sample added from the first buffer transfer position 77 and places it in the incubation transfer position 51a, the reagent dispensing component 60 adds reagent, such as the first reagent, to the reaction cup on the incubation transfer position 51a. The second transfer component 73 then picks up the reaction cup with reagent added, mixes it, and then transfers it to the reaction component 51. Specifically, the second transfer component 73 can mix the sample in the reaction cup held by the cup gripper 79 by driving the cup gripper 79 to shake rapidly through the drive component 73b. The second transfer component 73 also has a mixing function, so that the sample analysis device does not need to be equipped with a separate mixing mechanism, making the sample analysis device more compact and reducing costs. In addition, the second transfer component 73 mixes the sample while holding the reaction cup for transfer, which saves time and eliminates the need to specially arrange the reaction cup to the corresponding mixing mechanism for mixing first.

[0139] The above is a description of the second transfer component 73. The second transfer component 73 can transfer the reaction cup between the first buffer transfer position 77, the incubation transfer position 51a, the reaction component 51, and the second buffer transfer position 78 by moving linearly along the first and second directions.

[0140] The third transfer component 75 is used to transport the reaction cup in the second buffer transfer position 78 to the measurement component 52. In some embodiments, the third transfer component 75 transports the reaction cup in the second buffer transfer position 78 to the measurement component 52 by linear movement along a first direction, such as the direction shown in the figure, and a second direction, such as the X direction shown in the figure. Since the third transfer component 75 moves the reaction cup in a straight line, the volume of the sample analysis device occupied during the transport of the reaction cup is relatively reduced, which is beneficial to the miniaturization design of the sample analysis device.

[0141] In the specific transfer process, the third transfer component 75 can first transport the reaction cup from the second buffer transfer position 78 to the measurement transfer position 52a. The reagent dispensing component 60 aspirates the reagent and dispenses it into the reaction cup located at the measurement transfer position 52a. The third transfer component 75 then transports the reaction cup from the measurement transfer position 75a to the measurement component 52. In some embodiments, when the third transfer component 75 transfers the reaction cup from the second buffer transfer position 78 to the measurement transfer position 52a, the third transfer component 75 may not place the reaction cup at the measurement transfer position 52a, but may still hold the reaction cup. In this case, the reagent dispensing component 60 aspirates the reagent and dispenses it into the reaction cup. This reduces the time it takes for the reaction cup to finally enter the measurement component 52 from the second buffer transfer position 78, thus improving the testing speed.

[0142] In some embodiments, the third transfer component 75 can move along a first direction (e.g., the Y direction in the figure), a second direction (e.g., the X direction in the figure), and a vertical direction (e.g., the direction perpendicular to the drawing). Therefore, the driving component of the third transfer component 75 can be a three-dimensional driving component for driving the cup-gripping hand 79 of the third transfer component 75 to move along the first direction, the second direction, and the vertical direction. Referring to Figure 12(d), in some embodiments, the third transfer component 75 includes a first direction guide 75a, a first direction driving component 75b, a second direction guide 75c, a second direction driving component 75d, a vertical direction guide 75e, and a vertical direction driving component 75f. A cup-gripping hand 79 of the third transfer component 75 is slidably disposed on the vertical direction guide 75e, and driven by the vertical direction guide 75f, the cup-gripping hand 79 can move vertically along the vertical direction guide 75e. A vertical direction guide 75e is slidably disposed on the second direction guide 75c, and driven by the second direction driving component 75d, the vertical direction guide 75e can move in the second direction along the second direction guide 75c, thereby driving... The cup-gripping hand 79 of the third transfer component 75 also moves along the second direction; a second direction guide 75c is slidably disposed on the first direction guide 75a, and driven by the first direction driving component 75b, the second direction guide 75c can move along the first direction guide 75a in the first direction, thereby driving the second direction guide 75c to move along the first direction, thereby driving the vertical direction guide 75e on the second direction guide 75c to move in the first direction, thereby driving the cup-gripping hand 79 of the third transfer component 75 on the vertical direction guide 75e to move along the first direction; with this structure, the cup-gripping hand 79 of the third transfer component 75 can move in the three-dimensional directions of the first direction, the second direction and the vertical direction. In some specific embodiments, the first directional guide 75a may include a first guide rail; the first directional drive component 75b may include a first stepper motor, a first driven wheel, and a first synchronous belt, with the first synchronous belt sleeved between the first stepper motor and the first driven wheel, and the second directional guide 75c may be fixedly connected to the first synchronous belt; similarly, the second directional guide 75c may include a second guide rail; the second directional drive component 75d may include a second stepper motor, a second driven wheel, and a second synchronous belt, with the second synchronous belt sleeved between the second stepper motor and the second driven wheel, and the vertical directional guide 75e may be fixedly connected to the second synchronous belt; similarly, the vertical directional guide 75e may include a vertical guide rail; the vertical directional drive component 75f may include a lifting stepper motor and a vertical lead screw, with a mounting plate threaded onto the vertical lead screw for mounting the cup gripper 79 of the third transfer component 75. In some embodiments, the third transfer component 75 may also include a second bracket 75g for mounting the aforementioned first directional guide 75a.

[0143] In some embodiments, the gripper 79 of the third transfer component 75 grips the reaction cup along a first direction, such as the Y direction in the figure. This ensures that while the third transfer component 75 is gripping the reaction cup—even if it does so throughout the entire reagent addition process—it does not interfere with the reagent dispensing component 60 (e.g., the second reagent dispensing component) adding reagent to the reaction cup. This allows the reagent dispensing component 60 to complete reagent addition to the reaction cup simultaneously with the gripping action of the third transfer component 75, saving time and improving measurement speed and efficiency. In some embodiments, the direction in which the third transfer component 75 grips the reaction cup is greater than 90 degrees from the direction of linear movement of the second set of reagent needles. This further reduces the likelihood of conflict between the gripping action of the third transfer component 75 and the reagent addition action of the second set of reagent needles, allowing them to perform their respective actions independently and in parallel in a very reasonable manner.

[0144] In some embodiments, the third transfer component 75 mixes the sample in the reaction cup during the process of transporting the reaction cup from the measurement transfer position 52a to the measurement unit 52. For example, when the third transfer component 75 transfers the reaction cup from the second buffer transfer position 78 to the measurement transfer position 52a—in some embodiments, the third transfer component 75 may not put down the reaction cup while still holding it; the reagent dispensing component 60 then adds reagent, such as a second reagent, to the reaction cup at the measurement transfer position 52a, and the third transfer component 75 mixes the sample in the held reaction cup again before transferring it to the measurement unit 52; specifically, the third transfer component 75 can achieve the mixing of the sample in the reaction cup held by the cup gripper 79 by driving the cup gripper 79 to shake rapidly through the drive component 75b. The third transfer component 75 also has a mixing function, which eliminates the need for a separate mixing mechanism in the sample analysis device, making the structure of the sample analysis device more compact and reducing costs. In addition, the third transfer component 75 mixes the reaction cup along the original transfer path, such as at the intermediate transfer position 52a, which saves time and eliminates the need to specially arrange the reaction cup to the corresponding mixing mechanism for mixing.

[0145] In some examples, after the third transfer component 75 dispatches the reaction cup to the measuring component 52, it can also grab the reaction cup that has been measured in the measuring component 52 and then transfer it to the second cup-discarding position 10d for cup-discarding. In some embodiments, the second cup-discarding position 10d can be set near the second buffer transfer position 78, or set between the measuring component 52 and the second buffer transfer position 78. In this way, when the third transfer component 75 transfers the reaction cup on the second buffer transfer position 78 from the measuring component 52 to the second buffer transfer position 78, it can also perform cup-discarding on the measured reaction cup on the measuring component 52, thereby saving time and improving testing efficiency.

[0146] The above is a description of the third transfer component 75. The third transfer component 75 can transfer the reaction cup between the second buffer transfer position 78, the measuring transfer position 52a, the measuring component 52, and even the second cup-throwing position 10d by moving linearly along the first and second directions.

[0147] The above is a description of the scheduling component 70 in some embodiments of the present invention. This application completes the rapid transfer of reaction cups through three transfer components, namely the first transfer component 71, the second transfer component 73 and the third transfer component 75. The scheduling path of the reaction cups is simple and direct, which is beneficial to the speed-up of the sample analysis device. In addition, two buffer transfer positions, namely the first buffer transfer position 77 and the second buffer transfer position 78, are used to complete the transition between the three transfer components, which is also simple and compact in structure.

[0148] The above are sample analysis devices disclosed in some embodiments of the present invention. It is understood that the sample analysis device disclosed in the present invention may also include other structures, such as cleaning components and / or processors, etc., which will be discussed below in conjunction with... Figure 15 and Figure 16 Let me explain in detail.

[0149] The cleaning component is used to clean reagent needles, such as cleaning the first reagent needle and the second reagent needle. Specifically, the cleaning component may include multiple cleaning pools 81, the number of which can be the same as the number of reagent needles. For example, when the sample analysis device includes a first reagent dispensing component and a second reagent dispensing component, and each reagent dispensing component includes two reagent needles, then the number of cleaning pools can be four. A cleaning pool can be positioned along the linear movement trajectory of each reagent needle for cleaning the needles. Please refer to... Figure 16The cleaning unit is used to clean the reagent needle, specifically by cleaning the inner and outer walls of the needle with a cleaning solution. The cleaning unit includes a cleaning tank, piping, and valves installed on the piping, as shown in the diagram. A piping is connected to the end of the reagent needle, which is opened and closed by valve SV01. When valve SV01 is open, the cleaning solution can reach the end of the reagent needle through the piping, flow through the inner wall of the needle, and exit from the front end, completing the cleaning of the inner wall of the needle. A piping is also connected to the cleaning chamber, which is opened and closed by valve SV02. When valve SV02 is open, the cleaning solution can reach the cleaning chamber through the piping and spray from the inner wall of the cleaning chamber onto the outer wall of the reagent needle, completing the cleaning of the outer wall of the needle. A waste liquid suction valve SV03 is connected to the lower end of the cleaning chamber through a piping. When valve SV03 is open, the cleaned waste liquid flows out through the lower end of the cleaning chamber. During the cleaning process, the reagent needle moves to the top of the cleaning chamber and then downwards, inserting a portion of the needle (at least the part that came into contact with the reagent liquid surface when drawing the reagent) into the cleaning chamber. This allows the cleaning solution sprayed from the cleaning chamber to clean the portion of the needle that was in contact with the liquid surface, thus completing the cleaning of the reagent needle. All cleaning tanks 81 can share the same liquid path to provide the cleaning solution for cleaning the reagent needles.

[0150] The following describes some specific workflows of the sample analysis device.

[0151] In some embodiments, the sample analysis apparatus may operate in the following manner.

[0152] The reaction vessel loading component 10 supplies and transports empty reaction vessels. For example, the reaction vessel loading component 10 can load empty reaction vessels into a predetermined position, which can be used as a sample dispensing position. The sample component 20, such as the sample injection component, dispatches the sample holder carrying the sample to the aspiration position. The sample dispensing component 30 aspirates the sample from the aspiration position and dispenses it into the reaction vessel, for example, the sample dispensing component aspirates the sample from the aspiration position and dispenses it into the reaction vessel located at the sample dispensing position to complete the sample dispensing.

[0153] The driving component of the reagent carrier 40 drives the reagent carrier 40 to rotate, so that the reagent container carrying the first reagent is positioned at the first reagent aspiration position. At least one of the two reagent needles 61 on the first reagent dispensing component 60 draws the first reagent from the reagent container through the first reagent aspiration position and moves linearly between the first reagent aspiration position and the reagent addition position of the reaction component 51 to dispense the first reagent into the reaction cup at the reagent addition position of the reaction component 51. The reagent addition position of the reaction component 51 may be the incubation position 51a mentioned herein. In some embodiments, the two first reagent needles 61 of the first reagent dispensing component 60 move linearly independently between the first reagent aspiration position and the reagent addition position of the reaction component 51. In this way, the two first reagent needles 61 of the first reagent dispensing component 60 can independently—for example, alternately—perform the operation of adding the first reagent to the reaction cup at the reagent addition position of the reaction component 51, improving the testing speed and efficiency. In some specific embodiments, each first reagent needle 61 in the first reagent dispensing component 60 sequentially performs multiple preset actions to complete the first reagent dispensing operation, and at least one of the preset actions between any two first reagent needles 61 does not overlap in timing. In this way, the two reagent needles 61 of the first reagent dispensing component 60 can minimize the use of shared resources, reducing the number of components providing the corresponding shared resources, thus making the sample analysis device more compact. Furthermore, this arrangement of the timing of the actions of the two first reagent needles 61 also minimizes mutual interference between them, which is highly beneficial for increasing the speed of the sample analysis device.

[0154] The dispatching unit 70 dispatches the reaction cups that have completed the first reagent dispensing to the reaction unit 51 for incubation, and then dispatches the incubated reaction cups to the reagent addition transposition site of the measuring unit 52. The reagent addition transposition site of the measuring unit 52 may be the measuring transposition site 52a mentioned herein.

[0155] The reagent carrier 40 rotates so that the reagent container carrying the second reagent is positioned at the second reagent aspiration position. At least one of the two reagent needles on the second reagent dispensing component 60 draws the second reagent from the reagent container through the second reagent aspiration position and moves linearly between the second reagent aspiration position and the reagent addition position of the measuring component 52 to dispense the second reagent into the reaction cup at the reagent addition position of the measuring component 52. In some embodiments, the two second reagent needles 61 of the second reagent dispensing component 60 move linearly independently between the second reagent aspiration position and the reagent addition position of the measuring component 52. In this way, the two second reagent needles 61 of the second reagent dispensing component 60 can independently—for example, alternately—perform the operation of adding the second reagent to the reaction cup at the reagent addition position of the measuring component 52, improving the testing speed and efficiency. In some specific embodiments, each second reagent needle 61 in the second reagent dispensing component 60 sequentially performs multiple preset actions to complete the second reagent addition operation, and at least one of the multiple preset actions between any two pairs of second reagent needles 61 does not overlap in time. In this way, the two reagent needles 61 of the second reagent dispensing component 60 can minimize the occupation of public resources, thereby reducing the number of components that provide the corresponding public resources and making the sample analysis device more compact. Moreover, this arrangement of the timing of the two second reagent needles also minimizes their mutual interference, which is very beneficial for speeding up the sample analysis device.

[0156] The scheduling unit 70 schedules the reaction cups that have completed the second reagent dispensing to the measuring unit 52 for project testing, and schedules the reaction cups that have completed the testing to the waste recycling device—for example, the second discarding cup position mentioned in this article.

[0157] Some embodiments of the present invention also disclose a sample analysis method. Please refer to... Figure 17 In some embodiments, the sample analysis method includes the following steps:

[0158] Step 100, the reaction vessel loading step, involves controlling the reaction vessel loading component to supply and transport empty reaction vessels. For example, the reaction vessel loading component can load empty reaction vessels to a predetermined position, which can be used as a sample loading position.

[0159] Step 110, the sample feeding step, involves controlling the sample component, such as the sample feeding component, to move the sample holder carrying the sample to the sample suction position.

[0160] Step 120, the sample dispensing step, involves controlling the sample dispensing component to draw the sample from the aspiration position and dispense it into the reaction cup. For example, the sample dispensing component draws the sample from the aspiration position and then dispenses it into the reaction cup located at the dispensing position to complete the sample dispensing.

[0161] By completing steps 100 to 120 above, the sample addition is complete.

[0162] Step 130, the first reagent dispensing step, involves controlling the driving component of the reagent-carrying component to rotate, so that the reagent container holding the first reagent is positioned at the first reagent aspiration position; controlling at least one of the two reagent needles on the first reagent dispensing component to draw the first reagent from the reagent container through the first reagent aspiration position, and moving linearly between the first reagent aspiration position and the reagent addition transposition position of the reaction component, to dispense the first reagent into the reaction cup at the reagent addition transposition position of the reaction component. In step 130, the reagent addition transposition position of the reaction component can be the incubation transposition mentioned herein.

[0163] In some embodiments, step 130 controls the two first reagent needles of the first reagent dispensing component to move independently between the first reagent aspiration position and the reagent addition position of the reaction component in a linear motion. This allows the two first reagent needles of the first reagent dispensing component to independently—for example, alternately—add the first reagent to the reaction cup at the reagent addition position of the reaction component, improving testing speed and efficiency. In some specific embodiments, step 130 controls each first reagent needle in the first reagent dispensing component to sequentially perform multiple preset actions to complete the first reagent addition operation, and at least one of the preset actions between any two first reagent needles does not overlap in timing. This minimizes the use of shared resources by the two reagent needles of the first reagent dispensing component, reducing the number of components providing the corresponding shared resources, thus making the sample analysis device more compact. Furthermore, this arrangement of the timing of the two first reagent needles' actions minimizes mutual interference, which is highly beneficial for accelerating the sample analysis device. It should be noted that the multiple preset actions vary depending on different testing requirements. In one embodiment, the multiple preset actions include the following four: reagent aspiration, heating, reagent dispensing, and cleaning. Between each pair of first reagent needles, at least one of the four actions is not sequentially overlapping.

[0164] Step 130 completes the addition of the first reagent to the reaction vessel containing the sample.

[0165] Step 140, the incubation step, involves the control and scheduling unit moving the reaction cup that has completed the first reagent dispensing to the reaction unit for incubation, and then moving the incubated reaction cup to the reagent addition transposition site of the assay unit. In step 140, the reagent addition transposition site of the assay unit can be the assay transposition site mentioned herein.

[0166] Step 150, the second reagent dispensing step, involves controlling the reagent-carrying component to rotate so that the reagent container carrying the second reagent is positioned at the second reagent aspiration position; controlling at least one of the two reagent needles on the second reagent dispensing component to draw the second reagent from the reagent container through the second reagent aspiration position, and moving linearly between the second reagent aspiration position and the reagent addition position of the measuring component to dispense the second reagent into the reaction cup of the reagent addition position of the measuring component.

[0167] In some embodiments, step 150 controls the two second reagent needles of the second reagent dispensing component to move independently between the second reagent aspiration position and the reagent addition position of the measuring component in a linear motion. This allows the two second reagent needles of the second reagent dispensing component to independently—for example, alternately—add the second reagent to the reaction cup at the reagent addition position of the measuring component, improving testing speed and efficiency. In some specific embodiments, step 150 controls each second reagent needle in the second reagent dispensing component to sequentially perform multiple preset actions to complete the second reagent addition operation, and at least one of the preset actions between any two second reagent needles does not overlap in timing. This minimizes the use of shared resources by the two reagent needles of the second reagent dispensing component, reducing the number of components providing the corresponding shared resources, thus making the sample analysis device more compact. Furthermore, this arrangement of the timing of the two second reagent needles' actions minimizes mutual interference, which is highly beneficial for accelerating the sample analysis device. It should be noted that the multiple preset actions vary depending on different testing requirements. In one embodiment, the multiple preset actions include the following four: reagent aspiration, heating, reagent dispensing, and cleaning. Between each pair of second reagent needles, at least one of the four actions is not sequentially overlapping.

[0168] Step 150 completes the process of adding a second reagent to the reaction vessel containing the incubated reagent.

[0169] Step 160, namely the determination and recovery step, involves the control scheduling unit dispatching the reaction cup that has completed the second reagent dispensing to the determination unit for project testing, and dispatching the reaction cup that has completed the testing to the waste recovery device—the waste recovery device may have, for example, the second cup disposal position mentioned herein.

[0170] The above is an overall workflow of the sample analysis device.

[0171] The workflow of the reagent dispensing unit 60 imposes significant constraints on the testing speed, requiring each reagent needle to complete sample aspiration, heating, dispensing, and cleaning. The reagent carrier unit 40, used to ensure reagent activity, is generally kept at a low temperature, such as below 16°C. After being removed from the reagent carrier unit 40, the reagent needs to be heated to approximately 37°C within the reagent needle within a short time to ensure a complete reaction. Typically, the heating element of the reagent needle requires 4-10 seconds to heat the aspirated reagent. Different types of reagents need to be aspirated during different testing procedures. For example, in coagulation tests (PT / APTT / TT / FIB), different second reagents (trigger reagents) need to be aspirated from the reagent carrier unit 40 in turn and added to the reaction vessel for reaction. Therefore, the same reagent needle needs to be cleaned normally or thoroughly when aspirating reagents for different tests. To ensure cleaning effectiveness and avoid cross-contamination between reagents affecting the accuracy of test results, the cleaning time is generally 2-8 seconds. The sample aspiration and dispensing actions generally require 1.5-3 seconds (including the time for horizontal movement to reach the target position). Therefore, for sample analysis devices, such as those with a single working cycle of 8 seconds, it is quite difficult to complete all the above-mentioned actions such as sample aspiration, heating, sample discharge and cleaning within one working cycle, and the overall detection speed is reduced.

[0172] In some embodiments of the present invention, the design of how the sample analysis device performs reagent addition operations, i.e. how to arrange the timing of the actions of each reagent needle, is described in detail below.

[0173] In some embodiments, the processor controls each reagent needle within the same group to sequentially perform multiple preset actions—such as reagent aspiration, reagent heating in the reagent needle, reagent dispensing, and reagent needle cleaning—to complete the reagent dispensing operation. Furthermore, at least one of the preset actions between any two reagent needles within the same group does not overlap in timing. For example, in the first reagent dispensing component 60, the first group of reagent needles includes two first reagent needles, and at least one corresponding preset action between these two first reagent needles does not overlap in timing. Similarly, in the second reagent dispensing component 60, the second group of reagent needles includes two second reagent needles, and at least one corresponding preset action between these two second reagent needles does not overlap in timing. In some embodiments, a ping-pong mode can be set for the sample analysis device. When this mode is enabled, the processor executes the ping-pong mode so that at least one corresponding action between any two reagent needles in each group does not overlap in time. For example, in the reagent aspiration, reagent heating, reagent dispensing, and reagent cleaning actions of any two reagent needles in the same group, at least one corresponding action does not overlap in time. This at least one corresponding action includes the reagent aspiration action and / or the reagent cleaning action. In other embodiments, for all reagent needles (including the first and second reagent needles) performing reagent dispensing in the sample analysis device, the processor controls each reagent to sequentially perform multiple preset actions to complete the reagent dispensing operation, and at least one of the multiple preset actions between any two reagent needles does not overlap in time. For example, the first reagent needle includes first reagent needle a1 and first reagent needle a2, and the second reagent needle includes second reagent needle b1 and second reagent needle b2. When the processor controls the first reagent needle a1, the first reagent needle a2, the second reagent needle b1, and the second reagent needle b2 to each complete multiple preset actions, at least one corresponding preset action does not overlap in timing. By scheduling the timing of all reagent needles in the sample analysis device, the processor avoids interference and resource contention between the actions of the reagent needles, thereby making more effective use of shared resources and improving the sample testing efficiency of the sample analysis device.

[0174] In some embodiments, the aforementioned multiple preset actions may include a first type of preset action and a second type of preset action. The first type of preset action refers to actions where each reagent needle needs to interact with the same component. Typically, the first type of preset action may be actions where the reagent needles need to occupy common resources, such as reagent aspiration—which requires occupying the common component 40, or reagent needle cleaning—which requires occupying the pipeline that provides cleaning fluid to each cleaning pool 81. Therefore, the first type of preset action includes at least reagent aspiration and reagent needle cleaning. The second type of preset action refers to actions where each reagent does not need to interact with the same component. Typically, the second type of preset action may be actions where the reagent needles do not need to occupy common resources, such as reagent heating—each reagent needle heats the aspirated reagent through its own heating component. Therefore, the second type of preset action includes at least reagent heating in the reagent needle. In some embodiments, the corresponding first type of preset actions between any two reagent needles within the same group do not overlap in timing. For example, the reagent aspiration actions between any two reagent needles within the same group do not overlap in timing, and the reagent needle cleaning actions do not overlap in timing. Figure 18 This is one example.

[0175] In some embodiments, the preset actions of each of the multiple preset actions between any two reagent needles within the same group do not overlap in timing. For example Figure 19 Here's an example. In the first reagent dispensing unit 60, the first group of reagent needles includes two first reagent needles. The reagent aspiration actions between these two first reagent needles do not overlap in timing, the reagent heating actions within the reagent needles do not overlap in timing, the reagent dispensing actions do not overlap in timing, and the reagent cleaning and aspiration actions of the reagent needles do not overlap in timing. Similarly, in the second reagent dispensing unit 60, the second group of reagent needles includes two second reagent needles. The reagent aspiration actions between these two second reagent needles do not overlap in timing, the reagent heating actions within the reagent needles do not overlap in timing, the reagent dispensing actions do not overlap in timing, and the reagent cleaning and aspiration actions of the reagent needles do not overlap in timing.

[0176] In some embodiments, the time interval between the output results of two adjacent and identical test items when the sample analysis device completes a fixed test volume is defined as a cycle. The number of reagent needles set in each reagent dispensing component is equal to the number of cycles occupied by one reagent needle to complete the multiple preset actions. For example, if the number of cycles occupied by one reagent needle to complete the above-mentioned multiple preset actions (e.g., reagent aspiration, reagent heating in the reagent needle, reagent dispensing, and reagent needle cleaning) is two, then two reagent needles are set in the reagent dispensing component, or the number of reagent needles in the same group is two. From another perspective, in some embodiments, the processor controls each reagent needle of the reagent dispensing component to complete the multiple preset actions (e.g., reagent aspiration, reagent heating in the reagent needle, reagent dispensing, and reagent needle cleaning) within a preset time. This preset time is equal to N times the cycle, and N is equal to the number of reagent needles in the reagent dispensing component. For example, if each reagent dispensing component 60 has two reagent needles, then N is equal to two, and each reagent needle needs to complete the multiple preset actions (e.g., reagent aspiration, reagent heating in the reagent needle, reagent dispensing, and reagent needle cleaning) within two cycles. By setting the number of reagent needles in the reagent dispensing unit and the cycle for completing the multiple preset actions, the sample analysis device can ultimately achieve a testing speed equivalent to each reagent needle completing the multiple preset actions (e.g., reagent aspiration, reagent heating in the needle, reagent dispensing, and needle cleaning) within one cycle, ensuring a constant speed at which the sample analysis device outputs test results. A preset time is mentioned here. In some embodiments, if the time spent by the reagent needle performing the multiple preset actions is less than the preset time, to further ensure a constant speed at which the sample analysis device outputs test results, the reagent needle will wait until the waiting time plus the time spent completing the multiple preset actions equals the preset time. For clarity, the preset time includes both action time and waiting time, where the action time is used to perform the aforementioned preset actions (e.g., reagent aspiration, reagent heating in the needle, reagent dispensing, and needle cleaning), and the action time is less than or equal to the preset time. In some embodiments, the waiting time is divided into one or more time segments and inserted sequentially between the plurality of preset actions and / or after the last preset action—for example, inserted sequentially between and / or after the reagent aspiration action, the reagent heating action in the reagent needle, the reagent dispensing action, and the reagent needle cleaning action; for example Figure 20Here's an example. In some embodiments, the waiting time is divided into one or more segments, with at least one segment designated as additional action time for executing a preset action. This allows the preset action extra time to continue execution. Under the constraint of the preset time, the execution time of the preset action is extended, which can result in more stable performance of the reagent needle. For example, extending the execution time of reagent aspiration and dispensing actions allows the reagent needle to aspirate and dispensing reagents more stably, reducing the likelihood of empty aspiration or collisions with the reaction vessel. Similarly, extending the execution time of reagent heating in the reagent needle ensures that the reagent is fully preheated. Furthermore, extending the execution time of reagent needle cleaning allows for more thorough cleaning of the reagent needle, reducing the risk of cross-contamination to subsequent tests and improving the accuracy of test results. Therefore, in some embodiments, the sample analysis apparatus may include a fully heated mode, which, when enabled, is executed by the processor such that the waiting time is divided into one or more time segments, with at least one segment in the time sequence being used as additional action time for performing the reagent heating action in the reagent needle. For example Figure 21 This is one example.

[0177] There are some things to say. Figures 18 to 21 In the figure, for ease of plotting, the heating action refers to the reagent heating action in the reagent needle in this article, and the cleaning action refers to the reagent needle cleaning action in this article; Figures 18 to 21 The two reagent needles drawn in the middle refer to two reagent needles in the same group, such as the two first reagent needles in the first group of reagent needles, or the two second reagent needles in the second group of reagent needles.

[0178] This invention designs the timing of reagent needle action and introduces a reagent dispensing component with, for example, two reagent needles arranged in parallel. The two reagent needles, which run independently in a straight line, are coordinated by ping-pong to extend the cycle and complete the entire workflow of reagent aspiration, preheating, reagent dispensing and cleaning, providing double the resources and ensuring increased speed, thereby achieving the goal of testing multiple detection items without slowing down.

[0179] The following describes how the reaction cups are scheduled by the scheduling unit 70. In some embodiments, the present invention uses three transfer units and two buffer transfer positions to transfer the reaction cups.

[0180] Some embodiments of the present invention also disclose a method for sample analysis apparatus, please refer to... Figure 22 The method may include the following steps:

[0181] Step 200 involves controlling the first transfer component to transport the sample-added reaction vessel to the first buffer transfer position. In some embodiments, step 200 controls the first transfer component to move linearly along a first direction to transport the sample-added reaction vessel to the first buffer transfer position.

[0182] Step 210 involves controlling the second transfer component to transport the reaction cup from the first buffer transfer position to the incubation position. The incubation position can be the reaction cup placement position in the reaction component 51. In some embodiments, step 210 controls the second transfer component to transport the reaction cup from the first buffer transfer position to the incubation position via linear movement along a first direction and a second direction.

[0183] Step 220: Control the second transfer component to transport the reaction cup in the incubation position where the sample has been incubated to the transfer position in the second buffer.

[0184] In some embodiments, step 220 controls the second transfer component to transport the reaction cup in the incubation position, after sample incubation, to the second buffer transfer position via linear movement along the first direction and the second direction. In some specific embodiments, step 220 controls the second transfer component to first transport the reaction cup in the first buffer transfer position to the incubation transfer position for adding reagents, and then transport the reaction cup in the incubation transfer position after adding reagents to the incubation position to the incubation position.

[0185] In some specific embodiments, during step 220, when the reaction vessel is transferred from the incubation position to the incubation position, the second transfer component is controlled to mix the sample in the reaction vessel. While the second transfer component is transferring the reaction vessel, it also mixes the sample in the reaction vessel, saving time as it eliminates the need to specifically transfer the reaction vessel to the appropriate mixing mechanism beforehand.

[0186] Step 230: Control the third transfer component to transport the reaction cup in the second buffer to the measurement position.

[0187] In some embodiments, step 230 controls the third transfer component to transport the reaction cup from the second buffer transfer position to the measurement position via linear motion along the first direction and linear motion along the second direction. In some specific embodiments, step 230 controls the second transfer component to first transport the reaction cup from the second buffer transfer position to the measurement transfer position for adding reagents, and then transport the reaction cup with reagents added at the measurement transfer position to the measurement position.

[0188] In some specific embodiments, during step 230, when the reaction vessel is transferred from the second buffer to the measurement position, the third transfer component is controlled to mix the sample in the reaction vessel. While the third transfer component is transferring the reaction vessel, it also mixes the sample in the reaction vessel, saving time as it eliminates the need to specifically schedule the reaction vessel to the appropriate mixing mechanism beforehand.

[0189] The rapid transfer of reaction cups is achieved by three transfer components moving in a straight line. Combined with two buffer transfer positions, the scheduling path of the reaction cups is simple and direct, which is conducive to speeding up the sample analysis device.

[0190] Finally, let's take the sample analysis device, which includes a first reagent dispensing component 60 with two first reagent needles 61, a second reagent dispensing component 60 with two second reagent needles 61, a reaction component 51, and a measuring component 52, as an example to illustrate the present invention in conjunction with a specific test item.

[0191] The reaction unit 51 has a number of reaction cup placement positions and can heat the sample in the reaction cup located at the reaction cup placement position to incubate the sample. Depending on the test item, some test items require the addition of a first reagent, such as a mixed reagent. For example, when testing the APTT test item based on the coagulation method, the first reagent dispensing unit 60 draws the first reagent, such as a mixed reagent, from the reagent carrying unit 40 and discharges the drawn first reagent into the reaction cup located at the incubation transfer position 51a of the reaction unit 51, thereby completing the mixing of the first reagent and the sample. After the mixed reagent is added, the second transfer unit 73 can mix the reaction solution in the reaction cup and then place the reaction cup into the reaction unit 51, where the reaction unit 51 incubates the reaction solution, or sample, in the reaction cup.

[0192] To ensure reagent activity, the reagent carrier 40 typically operates at a low temperature, for example, below 16°C. To ensure a thorough coagulation reaction and accurate test results, the first reagent needs to be heated to approximately 37°C before being added to the reaction vessel and mixed with the sample. To improve the testing speed of the sample analysis device, the heating of the first reagent needs to be completed in a short time. Therefore, both first reagent needles 61 of the first reagent dispensing component 60 have heating elements to perform the reagent heating function. Typically, the reagent heating time requires 4 to 10 seconds. For high-speed sample analysis devices, a single working cycle is, for example, 8 seconds. This means that the reagent heating time is relatively long, which significantly impacts the testing speed of the sample analysis device. Therefore, in some embodiments of the present invention, the first reagent dispensing component 60 has two first reagent needles 61. The two first reagent needles 61 respectively draw the first reagent, such as a mixed reagent, from the reagent carrier 40, move it to the incubation transfer position 51a via a linear guide rail fixed on a linear beam, and alternately add the first reagent, such as a mixed reagent, to the reaction vessel. The two first reagent needles 61 are arranged in parallel and move independently. Because there are two independent first reagent needles 61, the working cycle time of the first reagent dispensing component 60 is doubled, which can be extended to 16 seconds. This ensures that the heating component of the reagent needle has sufficient heating time for the first reagent, so that the reagent temperature can be stably reached 37°C.

[0193] After the sample in the reaction vessel is heated and incubated in the reaction component 51 for a fixed time, the reaction vessel is transferred to the measuring component 52 by the cooperation of the second transfer component 73 and the third transfer component 75. In some embodiments, the sample may pass through the measuring intermediate transposition 52a during the process to add a second reagent, such as a triggering reagent.

[0194] The third transport component 75 transports the reaction cup to the measurement transposition position 52a. The second reagent dispensing component 60 draws a second reagent, such as a trigger reagent, from the reagent carrier component 40 and moves it above the reaction cup held by the third transport component 75, adding the second reagent, such as the trigger reagent, into the reaction cup, thus completing the mixing of the second reagent and the sample. After the trigger reagent is added, the third transport component 75 can mix the reaction solution in the reaction cup, and then place the reaction cup into the measurement component 52 for coagulation signal analysis and detection to obtain the test results.

[0195] Similar to the first reagent dispensing component 60, to ensure sufficient heating time for the second reagent, such as the trigger reagent, the second reagent dispensing component 60 also has two reagent needles, for example, two second reagent needles. These two second reagent needles draw the second reagent, such as the trigger reagent, from the reagent carrying component 40 and move to the measurement center position 52a via a linear guide fixed on a linear beam, alternately adding the second reagent, such as the trigger reagent, to the reaction vessel. These two second reagent needles 61 are arranged in parallel and move independently. Because there are two independent second reagent needles 61, the working cycle time of the second reagent dispensing component 60 is doubled, which can be extended to 16 seconds, ensuring sufficient heating time for the heating components of the reagent needles to heat the second reagent, so that the reagent temperature stably reaches 37°C.

[0196] In the measuring component 52, the reaction cup is irradiated with multi-wavelength light. The transmitted or scattered light is received by a photodetector within the measuring component 52, and a detection signal corresponding to the amount of light received is output. This detection signal can be sent to a processor for data analysis, processing, and generating corresponding display content. Sample analysis devices, such as fully automated coagulation analyzers, can employ different methods such as coagulation methods, immunoturbidimetric methods, and chromogenic substrate methods for sample analysis. Depending on the detection method, the measuring component 52 irradiates the reaction cup with light of different wavelengths, for example, between 405 nm and 800 nm.

[0197] The reaction cup that has completed the test can be transferred by the third transfer component 75 to the waste recycling device. The waste recycling device may have, for example, the second cup disposal position mentioned herein. The third transfer component 75 discards the reaction cup into the second cup disposal position to complete the waste disposal of the reaction cup.

[0198] This document describes various exemplary embodiments with reference to them. However, those skilled in the art will recognize that changes and modifications can be made to the exemplary embodiments without departing from the scope of this document. For example, various operational steps and components for performing operational steps can be implemented in different ways depending on the specific application or considering any number of cost functions associated with the operation of the system (e.g., one or more steps can be deleted, modified, or combined with other steps).

[0199] In the above embodiments, implementation can be achieved, in whole or in part, by software, hardware, firmware, or any combination thereof. Furthermore, as those skilled in the art will understand, the principles herein can be reflected in a computer program product on a computer-readable storage medium pre-loaded with computer-readable program code. Any tangible, non-transitory computer-readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROMs, DVDs, Blu-ray discs, etc.), flash memory, and / or the like. These computer program instructions can be loaded onto a general-purpose computer, special-purpose computer, or other programmable data processing apparatus to form a machine, such that instructions executing on the computer or other programmable data processing apparatus can generate means for performing a specified function. These computer program instructions can also be stored in a computer-readable storage medium that can instruct the computer or other programmable data processing apparatus to operate in a particular manner, such that instructions stored in the computer-readable storage medium can form an article of manufacture, including means for implementing the specified function. The computer program instructions can also be loaded onto a computer or other programmable data processing apparatus to perform a series of operational steps on the computer or other programmable apparatus to produce a computer-implemented process, such that instructions executing on the computer or other programmable apparatus can provide steps for implementing the specified function.

[0200] While the principles herein have been illustrated in various embodiments, numerous modifications to the structures, arrangements, proportions, elements, materials, and components, particularly suited to specific environments and operational requirements, may be used without departing from the principles and scope of this disclosure. These modifications and other alterations or alterations will be included within the scope of this document.

[0201] The foregoing specific descriptions have been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes can be made without departing from the scope of this disclosure. Therefore, considerations for this disclosure are to be illustrative rather than restrictive, and all such modifications are to be included within its scope. Similarly, advantages, other advantages, and solutions to problems with respect to various embodiments have been described above. However, benefits, advantages, solutions to problems, and any elements that produce these, or make them more explicit, should not be construed as critical, essential, or necessary. The term “comprising” and any other variations thereof as used herein are non-exclusive inclusion, meaning that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not expressly listed or not part of the process, method, system, article, or apparatus. Furthermore, the term “coupled” and any other variations thereof as used herein refer to physical connections, electrical connections, magnetic connections, optical connections, communication connections, functional connections, and / or any other connections.

[0202] Those skilled in the art will recognize that many changes can be made to the details of the above embodiments without departing from the basic principles of the invention. Therefore, the scope of the invention should be determined only by the claims.

Claims

1. A coagulation analysis device, characterized in that, include: The reaction vessel loading unit, scheduling unit, sample injection unit, sample dispensing unit, reagent carrying unit, reagent dispensing unit, reaction unit, measurement unit, cleaning tank, and processor are all included. The reaction cup loading component is used to supply and transport empty reaction cups; The scheduling component is used to schedule the reaction cups; The sample introduction component is used to direct the sample to be introduced to the sampling position; The sample dispensing component is used to draw a sample from the aspiration position and dispense it into a reaction cup located at the sample application position; The reagent carrier component is arranged in a disc shape and has multiple positions for carrying reagent containers. The reagent carrier component has a reagent suction position. The reagent carrier component can rotate and drive the reagent container it carries to rotate, so as to rotate the reagent container to the reagent suction position for the reagent dispensing component to draw up the reagent. The reagent dispensing component includes multiple reagent needles; The reaction component includes multiple reaction cup placement positions for holding reaction cups and incubating samples within them. The reaction component is equipped with a set of reagent needles and an incubation transfer position. The set of reagent needles includes multiple needles, and the incubation transfer position includes reaction cup placement positions. The number of reagent needles in the set is the same as the number of reaction cup placement positions in the incubation transfer position, so that each reagent needle in the set corresponds to one reaction cup placement position in the incubation transfer position. The set of reagent needles is used to draw mixed reagents from the reagent aspiration position in the same reagent-bearing component and discharge them into reaction cups at their respective reaction cup placement positions in the incubation transfer position. Each reagent needle in the set is configured to move independently along a straight line between the reagent aspiration position and its corresponding reaction cup placement position in the incubation transfer position. The scheduling component is used to schedule reaction cups located at the reaction cup placement positions in the incubation transfer position, after the mixed reagents have been discharged by their corresponding reagent needles, to the reaction cup placement positions in the reaction component for incubation. The measuring component includes multiple reaction cup placement positions for holding reaction cups and detecting samples within them. The measuring component is also equipped with another set of reagent needles and a measuring transfer position. This other set of reagent needles includes multiple needles, and the measuring transfer position includes reaction cup placement positions. The number of reagent needles in this other set is the same as the number of reaction cup placement positions in the measuring transfer position, so that each reagent needle in this other set corresponds to one reaction cup placement position in the measuring transfer position. This other set of reagent needles is used to draw trigger reagents from the aspiration position in the same reagent-bearing component and discharge them into the reaction cups at their respective reaction cup placement positions in the measuring transfer position. Each reagent needle in this other set is configured to move independently along a straight line between the aspiration position and the corresponding reaction cup placement position in the measuring transfer position. The scheduling component is used to schedule the reaction cups located at the reaction cup placement positions in the measuring transfer position, after the trigger reagents have been discharged by the corresponding reagent needles, to the reaction cup placement positions in the measuring component for coagulation analysis detection to obtain test results. The number of cleaning tanks is multiple, each positioned along the linear movement trajectory of the reagent needle, for cleaning the reagent needles; and The processor is used to control each reagent needle in the same group of reagent needles to sequentially perform reagent aspiration, reagent heating in the reagent needle, reagent dispensing, and reagent needle cleaning to complete the reagent addition operation; the coagulation analysis device includes a ping-pong mode, and the processor executes the ping-pong mode so that at least one corresponding action between any two reagent needles in each group of reagent needles does not overlap in timing.

2. The coagulation analysis device as described in claim 1, characterized in that, The at least one corresponding action includes a reagent aspiration action and / or a reagent needle cleaning action.

3. The coagulation analysis device as described in claim 1 or 2, characterized in that, When a coagulation analyzer completes a fixed number of tests, the time interval between the output results of two adjacent and identical test items is defined as a cycle. The number of reagent needles in the same group is equal to the number of cycles required for a reagent needle to complete the reagent aspiration, reagent heating, reagent dispensing, and reagent cleaning actions.

4. The coagulation analysis device as described in claim 3, characterized in that, The processor controls each reagent needle in the same group to sequentially complete the reagent aspiration, reagent heating, reagent dispensing, and reagent cleaning actions within a preset time. The preset time is equal to N times the cycle, and N is equal to the number of reagent needles in the reagent dispensing component.

5. The coagulation analysis device as described in claim 4, characterized in that, The same set of reagent needles consists of two reagent needles. The processor controls the two reagent needles to complete the reagent aspiration, reagent heating, reagent discharge, and reagent needle cleaning actions within two cycles.

6. The coagulation analysis device as described in claim 4 or 5, characterized in that, The preset time includes action time and waiting time, wherein the action time is used to perform the reagent aspiration action, the reagent heating action in the reagent needle, the reagent dispensing action, and the reagent needle cleaning action, and the action time is less than or equal to the preset time.

7. The coagulation analysis device as described in claim 6, characterized in that, The waiting time is divided into one or more time segments and is inserted in sequence between and / or after the reagent aspiration, reagent heating in the reagent needle, reagent dispensing, and reagent needle cleaning actions.

8. The coagulation analysis device as described in claim 6, characterized in that, It also includes a fully heated mode; the processor executes the fully heated mode such that the waiting time is divided into one or more time segments, and at least one segment is used as an additional action time for performing the reagent heating action in the reagent needle.

9. A coagulation analysis device, characterized in that, include: The reaction vessel loading unit, scheduling unit, sample injection unit, sample dispensing unit, reagent carrying unit, reagent dispensing unit, reaction unit, measurement unit, cleaning unit, and processor; The reaction cup loading component is used to supply and transport empty reaction cups; The scheduling component is used to schedule the reaction cups; The sample introduction component is used to direct the sample to be introduced to the sampling position; The sample dispensing component is used to draw a sample from the aspiration position and dispense it into a reaction cup located at the sample application position; The reagent carrier has multiple positions for holding reagent containers, and the reagent carrier has a reagent suction position for the reagent dispensing component to draw up the reagent; The reagent dispensing component has a reagent needle; The reaction component includes multiple reaction cup placement positions for holding reaction cups and incubating samples within them. The reaction component is equipped with a set of reagent needles and an incubation transfer position. The set of reagent needles includes multiple needles, and the incubation transfer position includes reaction cup placement positions. The number of reagent needles in the set is the same as the number of reaction cup placement positions in the incubation transfer position, so that each reagent needle in the set corresponds to one reaction cup placement position in the incubation transfer position. The set of reagent needles is used to draw mixed reagents from the reagent aspiration position in the same reagent-bearing component and discharge them into reaction cups at their respective reaction cup placement positions in the incubation transfer position. Each reagent needle in the set is configured to move independently along a straight line between the reagent aspiration position and its corresponding reaction cup placement position in the incubation transfer position. The scheduling component is used to schedule reaction cups located at the reaction cup placement positions in the incubation transfer position, after the mixed reagents have been discharged by their corresponding reagent needles, to the reaction cup placement positions in the reaction component for incubation. The measuring component includes multiple reaction cup placement positions for holding reaction cups and detecting samples within them. The measuring component is also equipped with another set of reagent needles and a measuring transfer position. This other set of reagent needles includes multiple needles, and the measuring transfer position includes reaction cup placement positions. The number of reagent needles in this other set is the same as the number of reaction cup placement positions in the measuring transfer position, so that each reagent needle in this other set corresponds to one reaction cup placement position in the measuring transfer position. This other set of reagent needles is used to draw trigger reagents from the aspiration position in the same reagent-bearing component and discharge them into the reaction cups at their respective reaction cup placement positions in the measuring transfer position. Each reagent needle in this other set is configured to move independently along a straight line between the aspiration position and the corresponding reaction cup placement position in the measuring transfer position. The scheduling component is used to schedule the reaction cups located at the reaction cup placement positions in the measuring transfer position, after the trigger reagents have been discharged by the corresponding reagent needles, to the reaction cup placement positions in the measuring component for coagulation analysis detection to obtain test results. Cleaning components are used to clean reagent needles; as well as The processor is used to control each reagent needle in the same group to perform multiple preset actions in sequence to complete the reagent addition operation, and at least one of the multiple preset actions between any two reagent needles in the same group does not overlap in timing.

10. The coagulation analysis device as described in claim 9, characterized in that, The multiple preset actions include a first type of preset action and a second type of preset action; the corresponding first type of preset actions between any two reagent needles in the same group do not overlap in time; wherein the first type of preset action is the action in which each reagent needle needs to interact with the same component, and the second type of preset action is the action in which each reagent does not need to interact with the same component.

11. The coagulation analysis device as described in claim 10, characterized in that, The first type of preset action includes at least the action of aspirating reagent and the action of cleaning reagent needle; the second type of preset action includes at least the action of heating reagent in reagent needle.

12. The coagulation analysis device according to any one of claims 9 to 11, characterized in that, In the multiple preset actions between two reagent needles within the same group, the corresponding preset actions do not overlap in time.

13. The coagulation analysis device according to any one of claims 9 to 11, characterized in that, When the coagulation analysis device completes a fixed amount of tests, the time interval between the output results of two adjacent and identical test items is defined as a cycle. The number of reagent needles set in the same group of reagent needles is equal to the number of cycles occupied by one reagent needle to complete the multiple preset actions.

14. The coagulation analysis device as described in claim 13, characterized in that, The processor controls each reagent needle in the same group to complete the multiple preset actions within a preset time. The preset time is equal to N times the cycle, and N is equal to the number of reagent needles in the same group.

15. The coagulation analysis device as described in claim 13, characterized in that, The same set of reagent needles consists of two reagent needles, and the processor controls the two reagent needles to complete the multiple preset actions within two cycles.

16. The coagulation analysis device as described in claim 14, characterized in that, The preset time includes an action time and a waiting time, wherein the action time is used to perform the preset action, and the action time is less than or equal to the preset time.

17. The coagulation analysis device as described in claim 16, characterized in that, The waiting time is divided into one or more time segments and is inserted in sequence between the multiple preset actions and / or after the last preset action.

18. The coagulation analysis device as described in claim 16, characterized in that, The waiting time is divided into one or more time segments, and at least one segment is used as additional action time to perform a preset action.

19. The coagulation analysis device as described in claim 18, characterized in that, The additional action time is used to perform the reagent heating action in the reagent needle.

20. The coagulation analysis device as described in claim 9, characterized in that, The reagent needle moves vertically to draw reagent from the reagent container and discharge the drawn reagent into the reaction cup.

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