Alcoholic composition

Abstract

The object of the present invention is to provide an alcohol composition that contains hydroxypropyl methylcellulose or methylcellulose in a manner that allows the thickening properties of hydroxypropyl methylcellulose or methylcellulose to be exerted, thereby not only having a viscosity that is easy to spread and does not drip easily, but also suppressing liquid dripping and / or improving transparency, and having a good spreadability. The above object is achieved by an alcohol composition comprising: 60 to 93 parts by mass of at least one alcohol selected from ethanol and isopropanol; 3.0 to 39.9 parts by mass of water; and 0.1 to 4 parts by mass of at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose and methylcellulose, wherein the loss tangent (tanδ) of the alcohol composition, measured at 20°C, a frequency of 1 Hz, and a deformation of 0.1%, is 0.10 to 1.00.

Description

Technical Field

[0001] This invention relates to alcohol compositions. Background Technology

[0002] Alcohol compositions are widely used in industry and in households. For example, hand sanitizers containing monohydric alcohols and water, cold preservers for pharmaceuticals and food containing polyhydric alcohols, cosmetics such as hairspray, and fragrances are used in a variety of applications.

[0003] The demand for alcohol-based hand sanitizers has surged, particularly since 2020, with widespread use not only in medical and nursing settings but also in ordinary households. For example, high-viscosity gel-based hand sanitizers offer advantages such as being less likely to spill and being easy to carry. To manufacture gel-based hand sanitizers, viscosity adjustments are necessary.

[0004] As thickeners for viscosity adjustment in alcohol compositions, acrylic polymers, polyvinyl alcohol, xanthan gum, cellulose derivatives, etc., can be used. For example, Patent Document 1 reports an alcohol composition using acrylic polymers, xanthan gum, and cellulose derivatives as thickeners (Patent Document 1).

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: Japanese Patent Publication No. 2008-508189 Summary of the Invention

[0008] The problem that the invention aims to solve

[0009] However, the alcohol composition described in Patent Document 1 has the problem of having a thickener content as low as 0.3%. Furthermore, cellulose ethers such as hydroxypropyl methylcellulose (hereinafter also referred to as "HPMC") and methylcellulose (hereinafter also referred to as "MC") have low solubility in alcohols. Therefore, when these cellulose ethers are mixed into a composition with a high alcohol concentration intended for use as a hand sanitizer, the cellulose ethers are insoluble in the alcohol, resulting in problems such as liquid dripping upon extrusion without exhibiting thickening properties and reduced transparency.

[0010] Furthermore, when using common acrylic polymers, the resulting alcohol compositions, due to their light feel, tend to feel dry after application.

[0011] Furthermore, in recent years, there has been an increasing awareness in society of the effective use of sustainable resources with lower environmental impact. From an environmental perspective, there is a desire to use sustainable resource components, primarily cellulose ethers such as hydroxypropyl methylcellulose and methylcellulose, and to reduce the substitution of synthetic polymers and the amount of synthetic polymers used.

[0012] Therefore, the object of the present invention is to provide an alcohol composition that contains hydroxypropyl methylcellulose or methylcellulose in a manner that allows the thickening properties of hydroxypropyl methylcellulose or methylcellulose to be utilized, thereby not only having a viscosity that is easy to spread and does not drip easily, but also suppressing liquid dripping and / or improving transparency, and having a good spreadability.

[0013] Methods for solving problems

[0014] The inventors, through dedicated research to achieve the aforementioned objectives, have successfully manufactured an alcohol composition that, even at high alcohol concentrations, contains hydroxypropyl methylcellulose or methylcellulose in a dissolved state in a manner that allows the thickening properties of hydroxypropyl methylcellulose or methylcellulose to be utilized. Surprisingly, the resulting alcohol composition exhibits a viscosity that is easy to apply and does not drip easily, suppresses liquid dripping, is non-sticky, and has a good spreadability; it also exhibits a viscosity that is easy to apply and does not drip easily, has high transparency, and provides a moist spreadability; or it exhibits a viscosity that is easy to apply and does not drip easily, suppresses liquid dripping, has high transparency, is non-sticky, and has a good spreadability. Furthermore, based on this insight, the inventors have ultimately successfully created an alcohol composition that contains hydroxypropyl methylcellulose or methylcellulose in a dissolved state in a manner that allows the thickening properties of hydroxypropyl methylcellulose or methylcellulose to be utilized, exhibiting excellent properties. This invention is based on the insights and successful examples first discovered by the inventors.

[0015] Therefore, according to the present invention, an alcohol composition in the following manner is provided:

[0016] The alcohol composition of the first aspect of the present invention comprises: 60.0 to 93.0 parts by weight of at least one alcohol selected from ethanol and isopropanol; 3.0 to 39.9 parts by weight of water; and 0.1 to 4.0 parts by weight of at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose and methylcellulose, wherein the loss tangent (tanδ) of the alcohol composition measured at 20°C, at a frequency of 1 Hz and with a deformation of 0.1%, is 0.10 to 1.00.

[0017] Preferably, the viscosity of a 2.0% by mass aqueous solution of the alcohol composition of the first embodiment of the present invention at 20°C is 2,500 mPa·s or higher.

[0018] Preferably, the alcohol composition of the first embodiment of the present invention does not contain at least one additive selected from hydroxyethyl cellulose and carboxyvinyl polymers.

[0019] The second embodiment of the alcohol composition of the present invention comprises: 40.0 to 88.0 parts by weight of at least one alcohol selected from ethanol and isopropanol; 8.0 to 59.9 parts by weight of water; and 0.1 to 4.0 parts by weight of at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose and methylcellulose, wherein the transmittance of the alcohol composition is 65.0% or more.

[0020] Preferably, the viscosity of a 2.0% by mass aqueous solution of the alcohol composition of the second embodiment of the present invention at 20°C is 1,500 mPa·s or higher.

[0021] Preferably, the alcohol composition of the second embodiment of the present invention does not contain at least one additive selected from hydroxyethyl cellulose and carboxyvinyl polymers.

[0022] The third embodiment of the alcohol composition of the present invention comprises: 60.0 to 88.0 parts by weight of at least one alcohol selected from ethanol and isopropanol; 8.0 to 39.9 parts by weight of water; and 0.1 to 4.0 parts by weight of at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose and methylcellulose. The alcohol composition has a loss tangent (tanδ) of 0.10 to 1.00 measured at 20°C, a frequency of 1 Hz, and a deformation of 0.1%, and a transmittance of 65.0% or more.

[0023] Preferably, the viscosity of a 2.0% by mass aqueous solution of the alcohol composition of the third embodiment of the present invention at 20°C is 2,500 mPa·s or higher.

[0024] Preferably, the alcohol composition of the third embodiment of the present invention does not contain at least one additive selected from hydroxyethyl cellulose and carboxyvinyl polymers.

[0025] Invention Effects

[0026] According to the first embodiment of the present invention, even with a relatively high alcohol concentration, the water-soluble cellulose ether added as a thickener is sufficiently dissolved, thus yielding an alcohol composition that not only has a viscosity that is easy to spread and does not easily sag, but also suppresses liquid dripping, is non-sticky, and has a good spreadability. According to the second embodiment of the present invention, even with a relatively high alcohol concentration, the water-soluble cellulose ether added as a thickener is sufficiently dissolved, thus yielding an alcohol composition that not only has a viscosity that is easy to spread and does not easily sag, but also has high transparency and a good appearance, maintains viscosity stability, and has a moist spreadability. According to the third embodiment of the present invention, even with a relatively high alcohol concentration, the water-soluble cellulose ether added as a thickener is sufficiently dissolved, thus yielding an alcohol composition that not only has a viscosity that is easy to spread and does not easily sag, but also prevents liquid dripping, has high transparency and a good appearance, maintains viscosity stability, is non-sticky, and has a good spreadability.

[0027] Furthermore, according to the present invention, even at a high alcohol concentration of 60% by mass or more, an alcohol composition having the above-mentioned characteristics can be obtained. Detailed Implementation

[0028] The following describes in detail one aspect of the alcohol composition of the present invention; however, the present invention can be carried out in various ways as long as its purpose is achieved.

[0029] Unless otherwise specified, all terms used in this specification are used in their common sense as understood by those skilled in the art and should not be unduly interpreted as having a limited meaning. Furthermore, any speculations or inferences made in this specification are based on the insights or experience of the inventors to date, and the invention is not limited to such speculations or inferences.

[0030] The term "composition" is used in a general sense without particular limitation, for example, it refers to a combination of two or more ingredients.

[0031] The term "and / or" refers to any one of the listed related items, or any combination of two or more, or all of the combinations.

[0032] "Content" and "dosage" are synonymous with "content," referring to the ratio of the amount of an ingredient to the total amount of the composition. In this specification, unless otherwise defined, the unit of content is "parts by mass." However, the total content of an ingredient shall not exceed 100 parts by mass.

[0033] The "~" in numerical range indicates a range that includes the values ​​before and after it. For example, "0% to 100%" refers to the range above 0% and below 100%. "Exceeding" and "insufficient" refer to the lower and upper limits, respectively, without including the values ​​before them. For example, "exceeding 1" means a value greater than 1, and "insufficient to 100" means a value less than 100.

[0034] "Including" means that elements other than the explicitly stated elements can be added to what is included (synonymous with "at least including"), including "composed of" and "essentially composed of". That is, "including" can mean including the explicitly stated elements as well as any one or more of the explicitly stated elements, being composed of the explicitly stated elements, or being substantially composed of the explicitly stated elements. Examples of elements include: ingredients, processes, conditions, parameters, and other limiting information.

[0035] The number of digits in an integer value is the same as the number of significant digits. For example, 1 has one significant digit, and 10 has two significant digits. Similarly, the number of digits below the decimal point in a decimal value is the same as the number of significant digits. For example, 0.1 has one significant digit, and 0.10 has two significant digits.

[0036] An alcohol composition according to one aspect of the present invention comprises: at least one alcohol selected from ethanol and isopropanol; water; and at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose and methylcellulose; and is an alcohol composition having a viscosity that is easy to apply and does not easily drip.

[0037] One aspect of the alcohol composition of the present invention has different contents in terms of the alcohol, water, and water-soluble cellulose ether, thereby having different properties. The alcohol composition of the present invention is generally divided into three aspects. In this specification, the alcohol composition of the first aspect is referred to as "alcohol composition A", the alcohol composition of the second aspect is referred to as "alcohol composition B", and the alcohol composition of the third aspect is referred to as "alcohol composition C".

[0038] That is, alcohol composition A comprises: 60.0 to 93.0 parts by mass of at least one alcohol selected from ethanol and isopropanol; 3.0 to 39.9 parts by mass of water; and 0.1 to 4.0 parts by mass of at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose and methylcellulose. Alcohol composition A is characterized by a loss tangent (tanδ) of 0.10 to 1.00 measured at 20°C, a frequency of 1 Hz, and a deformation of 0.1%, which can suppress liquid dripping, and provides a non-sticky and smooth application feel.

[0039] Alcohol composition B comprises: 40.0 to 88.0 parts by weight of at least one alcohol selected from ethanol and isopropanol; 8.0 to 59.9 parts by weight of water; and 0.1 to 4.0 parts by weight of at least one water-soluble cellulose ether selected from HPMC and MC. Alcohol composition B is characterized by a light transmittance of 65.0% or higher, providing high transparency and a moist, spreadable feel.

[0040] Alcohol composition C comprises: 60.0 to 88.0 parts by weight of at least one alcohol selected from ethanol and isopropanol; 8.0 to 39.9 parts by weight of water; and 0.1 to 4.0 parts by weight of at least one water-soluble cellulose ether selected from HPMC and MC. Alcohol composition C is characterized by a loss tangent (tanδ) of 0.10 to 1.00 measured at 20°C, a frequency of 1 Hz, and a deformation of 0.1%, and is characterized by a transmittance of 65.0% or higher. It provides an effect of not only being easy to apply and not prone to dripping, but also suppressing liquid dripping, exhibiting high transparency, being non-sticky, and having a good spreadability.

[0041] The following provides a detailed description of alcohol composition A, alcohol composition B, and alcohol composition C; however, common points can be referred to interchangeably.

[0042] <Alcohol Composition A>

[0043] Preferably, in order to increase the viscosity of the alcohol composition by means of a viscosity modifier, the viscosity modifier is homogeneously dissolved in the alcohol composition as a whole. In this case, when using water-soluble cellulose ethers such as HPMC and MC, which are poorly soluble in alcohols, as viscosity modifiers, increasing the proportion of water to dissolve HPMC and MC is a conventional method, resulting in a low alcohol concentration.

[0044] However, the inventors have discovered that alcohol compositions containing water-soluble cellulose ethers in a dissolved state, exhibiting excellent viscoelasticity, are characterized by a loss tangent (tanδ) of 0.10 to 1.00 measured at 20°C, 1 Hz, and 0.1% deformation, in a manner that allows the thickening properties of water-soluble cellulose ethers to be utilized. By achieving these rheological characteristics, alcohol compositions A, even with high alcohol concentrations, can achieve a viscosity that is easy to spread and does not easily drip, preventing liquid dripping, and possessing a non-sticky and good spreadability; for example, a gel form with suitable viscosity can even be obtained.

[0045] [Alcohols]

[0046] Alcohols are ethanol, isopropanol, or a mixture of ethanol and isopropanol.

[0047] The alcohol content in alcohol composition A can be anywhere from 60.0 parts by weight to 93.0 parts by weight, but from the viewpoint of the solubility of water-soluble cellulose ethers and the thickening properties imparted by water-soluble cellulose ethers, 60.0 parts by weight to 90.0 parts by weight is preferred, and more preferably 63.0 parts by weight to 85.0 parts by weight. Preferably, when using the alcohol composition as a disinfectant alcohol composition, the alcohol content is 70.0 parts by weight or more.

[0048] [water]

[0049] Water is not particularly limited; examples include ion-exchanged water, distilled water, and tap water. Additionally, aqueous solutions containing salts, water-soluble polymers, etc., can also be used, as long as they can dissolve water-soluble cellulose ethers.

[0050] The water content in alcohol composition A is only required to be 3.0 parts by weight to 39.9 parts by weight, but from the viewpoint of the solubility of water-soluble cellulose ether and the thickening properties imparted by water-soluble cellulose ether, it is preferred to be 6.0 parts by weight to 39.9 parts by weight, and more preferably 11.0 parts by weight to 36.9 parts by weight.

[0051] Hydroxypropyl methylcellulose (HPMC)

[0052] HPMC is a water-soluble cellulose ether formed by introducing methoxy and hydroxypropoxy groups into cellulose. HPMC does not have particularly limited properties regarding the degree of methoxy substitution, the molar number of hydroxypropoxy substitutions, viscosity, molecular weight, etc., and can be appropriately selected according to the desired characteristics such as viscosity imparted to the resulting alcohol composition. The method of obtaining HPMC is not particularly limited; it can be manufactured using methods known to date, or it can be obtained as a commercially available product.

[0053] As a method for manufacturing HPMC, water-soluble hydroxypropyl methylcellulose can be prepared by reacting an alkali in cellulose pulp to obtain alkali cellulose, then reacting the obtained alkali cellulose with a hydroxypropyl etherifying agent and a methylating agent, and then washing, drying, pulverizing, etc. on the obtained reactants.

[0054] The viscosity of HPMC is not particularly limited, but for example, in order to impart a desired viscosity to the alcohol composition, the viscosity of a 2.0% by mass aqueous solution of HPMC at 20°C is preferably 1,000 to 120,000 mPa·s, more preferably 1,500 mPa·s to 100,000 mPa·s, and even more preferably 2,000 mPa·s to 100,000 mPa·s. When the viscosity of HPMC is 1,000 mPa·s to 120,000 mPa·s, regardless of the alcohol content obtained, the viscosity of the alcohol composition can have a viscosity that allows it to exhibit a desired form such as a gel or liquid. Furthermore, if the viscosity of a 2.0% by mass aqueous solution of HPMC at 20°C is less than 1,000 mPa·s, the thickening effect imparted to the alcohol composition is weak, and there is a possibility that the viscosity stability of the alcohol composition is insufficient. On the other hand, when the viscosity of a 2.0% by mass aqueous solution of HPMC at 20°C exceeds 120,000 mPa·s, the compatibility and solubility of HPMC and alcohols deteriorate, resulting in a possible decrease in the thickening and / or transparency of the alcohol composition. The viscosity of a 2.0% by mass aqueous solution of HPMC at 20°C was measured using a single-cylinder rotational viscometer according to the "Viscosity Measurement Method" of the General Test Method described in the 17th edition of the Japanese Pharmacopoeia, as described in the examples below.

[0055] From the viewpoints of dispersibility and compatibility of alcohols, viscoelasticity of the alcohol composition, and transparency, the degree of substitution (DS) of methoxy groups in HPMC is preferably 1.00 or higher, more preferably 1.20 to 2.20, and even more preferably 1.30 to 2.10. The degree of substitution (DS) refers to the average number of methoxy groups per unit of dehydrated glucose.

[0056] From the viewpoints of alcohol dispersibility, alcohol compatibility, viscoelasticity of the alcohol composition, and transparency, the molar substitution number (MS) of hydroxypropoxy groups in HPMC is preferably 0.10 or more, more preferably 0.10 to 0.60, and even more preferably 0.13 to 0.40. The molar substitution number (MS) of hydroxypropoxy groups in HPMC refers to the average number of moles of hydroxypropoxy groups per unit of dehydrated glucose.

[0057] The DS of methoxy and the MS of hydroxypropoxy in HPMC were obtained by converting the values ​​measured using the determination method related to hydroxypropyl methylcellulose (hydroxypropyl methylcellulose) in the 17th revised edition of the Japanese Pharmacopoeia.

[0058] Depending on the alcohol concentration, there are different cases of HPMCs that can be used, and details will be explained in the section on manufacturing conditions of alcohol compositions A to C described later.

[0059] [Methylcellulose (MC)]

[0060] MC is a water-soluble cellulose ether formed by introducing methoxy groups into cellulose. The physical properties of MC, such as the degree of methoxy substitution, viscosity, and molecular weight, are not particularly limited, and can be appropriately selected according to the desired characteristics, such as viscosity, imparted to the resulting alcohol composition. The method of obtaining MC is not particularly limited; it can be manufactured using methods known to date, or it can be obtained as a commercially available product.

[0061] As a method for manufacturing MC, alkali cellulose can be obtained by reacting alkali in cellulose pulp, followed by reacting the obtained alkali cellulose with a methylating agent, and then the resulting reactants are washed, dried, pulverized, etc., thereby preparing water-soluble methylcellulose.

[0062] The viscosity of MC is not particularly limited, but for example, in order to impart a desired viscosity to the alcohol composition, the viscosity of a 2.0% by mass aqueous solution of MC at 20°C is preferably 1,000 mPa·s to 50,000 mPa·s, more preferably 1,500 mPa·s to 40,000 mPa·s, and even more preferably 2,000 mPa·s to 30,000 mPa·s. When the viscosity of MC is 1,000 mPa·s to 50,000 mPa·s, regardless of the alcohol content obtained, the viscosity of the alcohol composition can have a viscosity that allows it to exhibit a desired form such as a gel or liquid. Furthermore, if the viscosity of a 2.0% by mass aqueous solution of MC at 20°C is less than 1,000 mPa·s, the thickening effect imparted to the alcohol composition is weak, and there is a possibility that the viscosity stability of the alcohol composition is insufficient. On the other hand, when the viscosity of a 2.0% by mass aqueous solution of MC exceeds 50,000 mPa·s at 20°C, its compatibility with alcohols deteriorates, resulting in decreased solubility and potentially reduced thickening and / or transparency. The viscosity of a 2.0% by mass aqueous solution of MC at 20°C was measured using a single-cylinder rotational viscometer according to the "Viscosity Measurement Method" of the General Test Method described in the 17th revised edition of the Japanese Pharmacopoeia, as described in the examples below.

[0063] From the viewpoints of dispersibility and compatibility of alcohols, viscoelasticity of the alcohol composition, and transparency, the degree of substitution (DS) of the methoxy groups in MC is preferably 1.00 to 2.20, more preferably 1.30 to 2.10, and even more preferably 1.50 to 2.00. The degree of substitution (DS) refers to the average number of methoxy groups per unit of dehydrated glucose.

[0064] The DS of the methoxy group in MC was calculated by converting the value determined using the determination method related to methylcellulose in the 17th revised edition of the Japanese Pharmacopoeia.

[0065] The content of HPMC and / or MC in alcohol composition A is only 0.1 parts by weight to 4.0 parts by weight, but from the viewpoint of imparting thickening properties to the alcohol composition, it is preferably 0.1 parts by weight to 3.8 parts by weight, more preferably 0.1 parts by weight to 3.5 parts by weight, and even more preferably 1.0 parts by weight to 3.0 parts by weight.

[0066] [characteristic]

[0067] Alcohol composition A, provided it contains the specified alcohol, water, and water-soluble cellulose ether in the amounts described above, has a loss tangent (tanδ) of 0.10 to 1.00 measured at 20°C, a frequency of 1 Hz, and a deformation of 0.1%. Other properties are not particularly limited.

[0068] The viscosity of alcohol composition A is not particularly limited, but for example, to suppress liquid dripping and / or to have good spreadability, the viscosity at 20°C is preferably 2,500 mPa·s to 30,000 mPa·s, more preferably 3,000 mPa·s to 28,000 mPa·s, and even more preferably 3,200 mPa·s to 26,000 mPa·s. The viscosity of alcohol composition A is a value determined by the method described in "Viscosity of Alcohol Compositions" in the examples described later.

[0069] While a loss tangent (tanδ) of 0.10 to 1.00 is acceptable for alcohol composition A measured at 20°C, 1 Hz, and with a deformation of 0.1%, it is preferable, for example, to suppress liquid dripping and / or to provide a good spreadability, to be 0.10 to 0.90, and more preferably 0.15 to 0.85. Furthermore, the loss tangent (tanδ) of alcohol composition A is a value measured using the method described in the "Loss Tangent" section of the examples described later.

[0070] The transmittance of alcohol composition A is not particularly limited, but from an appearance point of view, it is preferably 10.0% or more, more preferably 14.0% or more, further preferably 20.0% or more, and even more preferably 24.0% or more. The upper limit of the transmittance of alcohol composition A is not particularly limited, typically 100.0%, but may be, for example, less than 65.0%. Furthermore, the transmittance of alcohol composition A is a value measured by the method described in the "Transmittance" section of the examples described later.

[0071] <Alcohol Composition B>

[0072] Alcohol composition B not only has a viscosity that is easy to apply and does not easily drip, but also has a light transmittance of over 65.0% and high transparency, giving it a moist application feel. The HPMC and / or MC of alcohol composition B are sufficiently stable in their solubility state, resulting in maintained viscosity stability, high transparency, and a good appearance.

[0073] [Alcohols, water, and water-soluble cellulose ethers]

[0074] The alcohols, water, and water-soluble cellulose ethers in alcohol composition B can be the same as those in alcohol composition A.

[0075] The alcohol content in alcohol composition B can be 40.0 parts by weight to 88.0 parts by weight, but from the viewpoint of the transparency and disinfection effect of the alcohol composition, it is preferred to be 45.0 parts by weight to 85 parts by weight, more preferably 50.0 parts by weight to 82.0 parts by weight, and even more preferably 60.0 parts by weight to 82.0 parts by weight.

[0076] The water content in alcohol composition B can be 8.0 parts by weight to 59.9 parts by weight, but from the viewpoint of transparency of the alcohol composition, it is preferred to be 11.0 parts by weight to 54.9 parts by weight, more preferably 14.0 parts by weight to 49.9 parts by weight, and even more preferably 14.0 parts by weight to 39.9 parts by weight.

[0077] The content of HPMC, MC, or both in alcohol composition B is only 0.1 to 4 parts by mass, but from the viewpoint of imparting thickening and transparency to the alcohol composition, it is preferably 0.1 to 3.8 parts by mass, more preferably 0.1 to 3.5 parts by mass, and even more preferably 1.0 to 3.0 parts by mass.

[0078] [characteristic]

[0079] Alcohol composition B is not particularly limited in other properties as long as it contains the specified alcohol, water and water-soluble cellulose ether in the above-mentioned amounts and has a light transmittance of 65.0% or more.

[0080] The viscosity of alcohol composition B is not particularly limited, but for example, to achieve a wet, spreadable feel, the viscosity at 20°C is preferably 1500 mPa·s to 30,000 mPa·s, more preferably 2,500 mPa·s to 26,000 mPa·s, and even more preferably 3,000 mPa·s to 20,000 mPa·s. The viscosity of alcohol composition B is a value measured by the method described in the "Viscosity of Alcohol Compositions" section of the examples described later.

[0081] While a transmittance of 65.0% or higher is sufficient for alcohol composition B, it is preferable to have 70.0% or higher, more preferably 72.0% or higher, even more preferably 75.0% or higher, and even more preferably 80.0% or higher, for example, to ensure a good appearance of alcohol composition B. The upper limit of the transmittance of alcohol composition B is not particularly limited; for example, it can be 100.0%. Furthermore, the transmittance of alcohol composition B is a value measured using the method described in the "Transmittance" section of the examples described later.

[0082] The loss tangent (tanδ) of alcohol composition B, measured at 20°C and 1 Hz with a deformation of 0.1%, is not particularly limited and may exceed 1.00, for example. From the viewpoint of good spreadability, the upper limit of the loss tangent (tanδ) of alcohol composition B, measured at 20°C and 1 Hz with a deformation of 0.1%, is preferably 5.00, more preferably 3.50, further preferably 2.30, and even more preferably 1.55 from the viewpoint of preventing liquid dripping. Furthermore, the loss tangent (tanδ) of alcohol composition B is a value measured by the method described in the "loss tangent" examples described later.

[0083] <Alcohol Composition C>

[0084] Although alcohol composition C has a high alcohol concentration, it contains water-soluble cellulose ether in a dissolved state in a manner that allows the thickening properties of the water-soluble cellulose ether to be exerted. It also has the following properties: the loss tangent (tanδ) of alcohol composition A at 20°C with a frequency of 1 Hz and a deformation of 0.1% is 0.10 to 1.00, and the transmittance of alcohol composition B is 65.0% or higher.

[0085] By possessing these properties, alcohol composition C can have a viscosity that is easy to spread and does not easily drip, even at high alcohol concentrations. It not only prevents liquid from dripping but also maintains viscosity stability and a good appearance. Furthermore, it is non-sticky and has a good spreadability. For example, it can even achieve a gel form with a suitable viscosity.

[0086] [Alcohols, water, and water-soluble cellulose ethers]

[0087] The alcohols, water, and water-soluble cellulose ethers in alcohol composition C can be the same as those in alcohol composition A.

[0088] The alcohol content in alcohol composition C is only required to be 60.0 parts by weight to 88.0 parts by weight, but from the viewpoint of thickening and transparency of alcohol composition, it is preferred to be 60.0 parts by weight to 87.0 parts by weight, and more preferably 60.0 parts by weight to 85.0 parts by weight.

[0089] The water content in alcohol composition C is only 8.0 parts by weight to 39.9 parts by weight, but from the viewpoint of imparting thickening and transparency to the alcohol composition, it is preferably 9.0 parts by weight to 39.9 parts by weight, and more preferably 11.0 parts by weight to 39.9 parts by weight.

[0090] The content of HPMC, MC, or both in alcohol composition C is only 0.1 to 4.0 parts by mass, but from the viewpoint of imparting thickening and transparency to the alcohol composition, it is preferably 0.1 to 3.8 parts by mass, more preferably 0.1 to 3.5 parts by mass, and even more preferably 1.0 to 3.0 parts by mass.

[0091] [characteristic]

[0092] As long as the alcohol composition C contains the specified alcohol, water, and water-soluble cellulose ether in the above-mentioned amounts, and has a loss tangent (tanδ) of 0.10 to 1.00 measured at 20°C, a frequency of 1 Hz, and a deformation of 0.1%, and has a transmittance of 65.0% or more, other properties are not particularly limited.

[0093] The viscosity of alcohol composition C is not particularly limited, but for example, to suppress liquid dripping and / or to have a good spreadability, the viscosity at 20°C is preferably 2,500 mPa·s to 30,000 mPa·s, more preferably 3,000 mPa·s to 28,000 mPa·s, further preferably 4,000 mPa·s to 26,000 mPa·s, and even more preferably 4,500 mPa·s to 26,000 mPa·s. The viscosity of alcohol composition C is a value determined by the method described in "Viscosity of Alcohol Compositions" in the examples described later.

[0094] While a transmittance of 65.0% or higher is acceptable for alcohol composition C, it is preferable to have 70.0% or higher, more preferably 72.0% or higher, and even more preferably 76.0% or higher, for example, to ensure a good appearance of alcohol composition C. The upper limit of the transmittance of alcohol composition C is not particularly limited; for example, it can be 100.0%. Furthermore, the transmittance of alcohol composition C is a value measured using the method described in the "Transmittance" section of the examples described later.

[0095] While a loss tangent (tanδ) of 0.10 to 1.00 is acceptable for alcohol composition C measured at 20°C, 1 Hz, and with a deformation of 0.1%, a value of 0.10 to 0.90 is preferred, for example, to suppress liquid dripping and / or to provide good spreadability, and more preferably, 0.15 to 0.85. Furthermore, the loss tangent (tanδ) of alcohol composition C is a value measured using the method described in the "Loss Tangent" section of the examples described later.

[0096] <Additives>

[0097] In order to impart the desired properties, one embodiment of the alcohol composition of the present invention may contain other additives in addition to alcohols, water, and water-soluble cellulose ethers.

[0098] Additives are not particularly limited as long as they do not hinder the solution of the problem of the present invention. Examples include bactericides, viscosity modifiers, pH adjusters, fragrances, pigments, dyes, antioxidants, preservatives, humectants, etc.

[0099] Examples of fungicides include benzalkonium chloride, triclosan, and cypress alcohol.

[0100] Examples of viscosity modifiers include water-soluble polymers such as guar gum, locust bean gum, carboxymethyl cellulose, hydroxyethyl cellulose, hydrophobic hydroxypropyl methyl cellulose, cationic hydroxyethyl cellulose, carboxyvinyl polymers, and polyvinyl alcohol. However, for hydroxyethyl cellulose, from the viewpoint of deterioration of compatibility and resulting deterioration of liquid dripping and spreadability due to the lower molar substitution number, and from the viewpoint of deterioration of liquid dripping and spreadability due to the higher molar substitution number, it is preferable to remove hydroxyethyl cellulose. Furthermore, from the viewpoint of spreadability and reduction of synthetic polymers, it is preferable to remove carboxyvinyl polymers. Therefore, alcohol compositions A, B, and C are preferably free of hydroxyethyl cellulose and carboxyvinyl polymers.

[0101] Examples of pH adjusters include: alkali metal hydroxides such as sodium hydroxide and potassium hydroxide; alkaline earth metal hydroxides such as calcium hydroxide and magnesium hydroxide; ammonium carbonate; ammonia; ammonia water; trisodium phosphate; disodium hydrogen phosphate; dipotassium hydrogen phosphate; alkyl secondary amines such as dimethylamine and diethylamine; alkyl tertiary amines such as trimethylamine and triethylamine; monoethanolamine; isopropanolamine; diethanolamine; diisopropanolamine; triethanolamine; triisopropanolamine; polyethanolamine, etc.

[0102] Examples of fragrance ingredients include: rose oil, jasmine oil, lavender oil, ylang-ylang oil, peppermint oil, geranium oil, patchouli oil, sandalwood oil, cinnamon oil, lemon oil, orange oil, bergamot oil, limonene, β-caryophyllene, cis-3-hexenol, linalool, farnesol, β-phenylethanol, 2,6-nonadienol, citral, α-hexylcinnamaldehyde, ι-carvone, cyclopentadecanol, linalyl acetate, γ-undecyl lactone, nerolidin, etc.

[0103] Examples of pigments include: titanium dioxide, zinc oxide, barium sulfate, zinc oxide coated or compounded with silicic anhydride, iron oxide (Indian red), iron titanate, γ-iron oxide, yellow iron oxide, loess, black iron oxide, carbon black, and low-valent titanium oxide.

[0104] Examples of dyes include: acid dyes, nitro dyes, disperse dyes, basic dyes, and intermediates of oxidative dyes.

[0105] Examples of antioxidants include: tocopherol, tocopherol acetate, ascorbic acid, butylated hydroxyanisole, and butylated hydroxytoluene.

[0106] Examples of preservatives include methylparaben, ethylparaben, propylparaben, butylparaben, and phenoxyethanol.

[0107] Examples of moisturizers include: hyaluronic acid, sodium hyaluronate, polyethylene glycol, mucopolysaccharides, urea, sorbitol, chondroitin sulfate, pyrrolidone carboxylic acid, sodium lactate, polyaspartic acid, glycerin, propylene glycol, 1,3-propylene glycol, dipropylene glycol, 1,3-butanediol, diglycerin, pentylene glycol, etc.

[0108] The additives can be used alone or in combination with two or more of the above-mentioned additives. Furthermore, both commercially available additives and additives manufactured using methods known to date can be used.

[0109] The content of the additive is appropriately varied depending on the desired properties imparted to the alcohol composition and its intended use. For example, from the viewpoint of storage stability of the alcohol composition, it is preferably 0.001 parts by weight to 20.0 parts by weight. However, when the additive is glycerol, propylene glycol, 1,3-propylene glycol, dipropylene glycol, 1,3-butanediol, diglycerol, or pentanediol, from the viewpoint of solubility, the content of the additive is preferably 0.001 parts by weight to 10 parts by weight.

[0110] <Method for manufacturing alcohol compositions>

[0111] The manufacturing method is not particularly limited as long as an alcohol composition according to one aspect of the present invention is available. However, water-soluble cellulose ethers such as HPMC and MC are poorly soluble in alcohols. When the alcohol concentration is set high, there is a tendency for the following problems to occur: even if the water-soluble cellulose ether is to be dissolved, sufficient hydration will not occur, but only the surface will become wet and partially dissolved clumps (small powder particles) will form; precipitation and sedimentation of water-soluble cellulose ethers may occur after the preparation of the alcohol composition. As a result of these problems, the viscosity of the alcohol composition becomes insufficient, the transparency decreases, and there is a possibility that it does not have the desired properties.

[0112] In view of this problem, the inventors have repeatedly experimented with and diligently studied various steps to suppress the formation of small clumps during the dissolution of water-soluble cellulose ethers and the precipitation and sedimentation of water-soluble cellulose ethers after the preparation of alcohol compositions, even when the alcohol concentration is set at a high level. Surprisingly, by sequentially implementing the steps of dispersing water-soluble cellulose ethers of HPMC and MC in a first alcohol to obtain a dispersion, mixing the dispersion with water to obtain a solution of water-soluble cellulose ethers, and mixing the solution with a second alcohol to obtain an alcohol composition, the formation of small clumps during the dissolution of water-soluble cellulose ethers and the precipitation and sedimentation of water-soluble cellulose ethers after the preparation of alcohol compositions were suppressed, and alcohol compositions A, B, and C were successfully manufactured. Therefore, preferably, an alcohol composition according to one aspect of the present invention is manufactured by a method including the above-described steps. Hereinafter, a preferred method for manufacturing an alcohol composition according to one aspect of the present invention will be described.

[0113] A preferred method for manufacturing an alcohol composition according to an embodiment of the present invention comprises: a step of obtaining a dispersion by dispersing at least one water-soluble cellulose ether selected from HPMC and MC in a first alcohol (hereinafter also referred to as the "step of obtaining the dispersion"); a step of obtaining a solution by dissolving the cellulose ether by mixing the dispersion with water (hereinafter also referred to as the "step of obtaining the solution"); and a step of obtaining an alcohol composition by mixing the solution with a second alcohol (hereinafter also referred to as the "step of obtaining the alcohol composition").

[0114] [Process for obtaining the dispersion]

[0115] In the process of obtaining the dispersion, the dispersion is obtained by dispersing cellulose ethers of HPMC, MC, or both in a first alcohol.

[0116] In this method, the alcohol is prepared in two stages, consisting of a first alcohol and a second alcohol. The content of the first alcohol is not particularly limited. However, in this method, it is preferable that the content of the first alcohol does not impede the adequate hydration of the cellulose ether. For example, by maintaining a certain relationship between the mass of the first alcohol and the total mass of the first and second alcohols, the solubility stability of the cellulose ether can be improved, allowing the water-soluble cellulose ether to hydrate well. To achieve this adequate hydration of the cellulose ether, preferably, the ratio of the mass of the first alcohol to the total mass of the first and second alcohols ([first alcohol] / [first alcohol + second alcohol], hereinafter referred to as "first alcohol content") is 0.7 or less, more preferably 0.61 or less. When the ratio exceeds 0.70, the water ratio in the solution decreases in the subsequent process of obtaining the solution. The water content that can help dissolve the cellulose ether is insufficient, and the hydration becomes inadequate. As a result, the cellulose ether is not fully dissolved, and the thickening properties expected of the obtained alcohol composition cannot be achieved.

[0117] For example, if the mass of the first alcohol is 20 parts by mass and the content of the first alcohol is 0.267, the total mass of the alcohol is 75 parts by mass and the mass of the second alcohol is 55 parts by mass.

[0118] This method disperses water-soluble cellulose ethers in the first alcohol by dividing an alcohol into a first alcohol and a second alcohol. This eliminates the need for hot water for dispersion, which is required to pre-condition the aqueous solution of the water-soluble cellulose ether. As a result, it reduces the time and electricity costs associated with heat treatment and subsequent cooling to below the dissolution temperature.

[0119] The conditions for dispersing water-soluble cellulose ethers in the first alcohol are not particularly limited, and conditions known to date for dispersing solids in solvents can be used. For example, the water-soluble cellulose ether can be dispersed in the first alcohol by mixing it with the first alcohol and stirring, thereby obtaining a dispersion.

[0120] When mixing is used as a mixing process, the mixing method is not particularly limited, and the following mixing methods can be used: homogenizer, homogenizing mixer, homogenizing disperser, jet mixer, ultrasonic mixer, colloid mill, three-in-one motor, etc.

[0121] The stirring temperature is not particularly limited, but is preferably 0℃~40℃, and more preferably 0℃~35℃; the stirring time is not particularly limited, but is preferably 1 minute~30 minutes, and more preferably 5 minutes~15 minutes.

[0122] In the process of obtaining the dispersion, a homogeneous dispersion can be obtained by visually confirming that there are no substantially no lumps (agglomerates (small powder particles)) of water-soluble cellulose ether, or that the cellulose ether is in a state before mixing or is agglomerated. Furthermore, it is preferable that the dispersion remains homogeneous for at least one hour after standing. For good dispersion in the first alcohol, the water-soluble cellulose ether is preferably in powder form, and more preferably has an average particle size of 10 μm to 100 μm as determined by dry laser diffraction.

[0123] [Process for obtaining the solution]

[0124] In the process of obtaining the solution, the water-soluble cellulose ether is dissolved by mixing the dispersion obtained in the process of obtaining the dispersion with water.

[0125] The water temperature can be appropriately set according to the type of water-soluble cellulose ether, for example, 0℃~35℃. Considering the property that water-soluble cellulose ethers have higher solubility at lower temperatures, 0℃~30℃ is preferred, and 0℃~20℃ is even more preferred.

[0126] The conditions under which the dispersion and water are mixed to dissolve the water-soluble cellulose ether are not particularly limited, and conditions known to date for dissolving substances in the dispersion in water can be used. For example, from an operational point of view, it is preferable to add water to the dispersion and mix it.

[0127] As a mixing process, stirring is preferred. The stirring method is not particularly limited, and examples include: homogenizers, homogenizing mixers, homogenizing dispersers, jet mixers, ultrasonic mixers, colloid mills, and three-in-one motors. The stirring method can be the same as that used in the process of obtaining the dispersion, or it can be a different stirring method.

[0128] The stirring temperature is not particularly limited as long as it is the temperature at which the water-soluble cellulose ether dissolves, but is preferably 0°C to 35°C, and more preferably 0°C to 25°C. The stirring time is not particularly limited as long as it is the time it takes for the water-soluble cellulose ether to dissolve completely, but is preferably 10 minutes to 60 minutes.

[0129] In the process of obtaining the solution, a solution can be said to be obtained when it is visually confirmed that there is no substantial separation or precipitation of water-soluble cellulose ethers. In order to improve the solubility of water-soluble cellulose ethers, part or all of the process can be carried out simultaneously with cooling in the process of obtaining the solution.

[0130] [Process for obtaining the alcohol composition]

[0131] In the process of obtaining the alcohol composition, the alcohol composition is obtained by mixing the solution obtained in the process of obtaining the solution with the second alcohol.

[0132] The conditions for mixing the solution and the second alcohol to obtain the alcohol composition are not particularly limited, and conditions for mixing liquids together, as known to date, can be used. For example, from an operational point of view, it is preferable to add the second alcohol to the solution and mix it by stirring or the like. The stirring means is not particularly limited, and examples of stirring devices such as homogenizers, homogenizing mixers, homogenizing dispersers, jet mixers, ultrasonic mixers, colloid mills, and three-in-one motors can be used. The stirring means can be the same as that used in the process of obtaining the dispersion and / or the process of obtaining the solution, or it can be a different stirring means. However, in order to improve the solubility stability of the water-soluble cellulose ether in the alcohol composition and the homogeneity of the components in the alcohol composition, it is preferable to subject the solution and the second alcohol to vigorous mixing, more preferably vigorous mixing, and even more preferably homogenization.

[0133] The stirring temperature is not particularly limited, but is preferably 0℃ to 35℃, and more preferably 0℃ to 25℃. The stirring time is not particularly limited, but is preferably 20 minutes to 90 minutes.

[0134] In the process of obtaining the alcohol composition, the alcohol composition can be said to be obtained when it is visually confirmed that there is substantially no separation or precipitation of water-soluble cellulose ethers. If the dissolution of water-soluble cellulose ethers is insufficient, the separated or precipitated portion of the water-soluble cellulose ethers tends to precipitate after the alcohol composition has been left to stand for one week. Therefore, the alcohol composition is preferably one in which, after standing for one week, no separation or precipitation of water-soluble cellulose ethers is visually observed to have occurred. In the process of obtaining the alcohol composition, in order to improve the solubility of water-soluble cellulose ethers, part or all of the process can be carried out simultaneously with cooling.

[0135] [Preparation conditions for alcohol compositions A to C]

[0136] During their research, the inventors discovered that by setting the degree of substitution (DS) of the methoxy group of the water-soluble cellulose ether and the molar number of substitutions (MS) of the hydroxypropoxy group, the alcohol concentration (mass %), X, and the content of the first alcohol (%), they were able to arbitrarily manufacture alcohol composition A, alcohol composition B, and alcohol composition C.

[0137] That is, by the preferred method of manufacturing the alcohol composition of the present invention described above, namely, the method comprising the steps of obtaining a dispersion, obtaining a solution, and obtaining an alcohol composition, if DS, MS, X, and Y, and Z calculated based on these values ​​according to the following formula, are set to the relationships described in Tables 1 to 3 below, then alcohol composition A, alcohol composition B, and alcohol composition C can be manufactured.

[0138] (DS+MS) / X×Y=Z (where X>Y)

[0139] In addition, the values ​​of DS, MS, X, Y and Z in Tables 1 to 3 are guideline values ​​and should not be interpreted as meaning that various alcohol compositions can only be manufactured within these ranges.

[0140] Alcohol composition A can be manufactured under the conditions shown in Table 1, where DS, MS, X, Y, and Z meet the requirements. In Table 1, the cellulose ether used in condition I is MC, and the cellulose ether used in conditions II to IV is HPMC.

[0141] Table 1

[0142] conditions DS MS X Y Z I 1.0～2.2 0.00 60.0～80.0 10～70 0.21～2.40 II 1.5～2.2 0.15～0.35 83.0～93.0 10～70 0.22～1.70 III 1.5～2.2 0.10～0.21 68.0～80.0 10～70 0.22～2.00 IV 1.0～1.8 0.10～0.30 60.0～80.0 10～70 0.20～2.00

[0143] From the viewpoint of the solubility of HPMC in the alcohol composition and its thickening properties imparted to the alcohol composition, the DS and MS of the HPMC used in conditions II to IV are preferably in a specified relationship. For example, the HPMC used in condition II preferably has a DS of 1.60 to 2.10 and an MS of 0.17 to 0.30; the HPMC used in condition III preferably has a DS of 1.60 to 2.10 and an MS of 0.12 to 0.21; and the HPMC used in condition IV preferably has a DS of 1.20 to 1.70 and an MS of 0.17 to 0.30.

[0144] Furthermore, since an alcohol composition A with excellent workability and solubility of water-soluble cellulose ethers is tended to be obtained as a result, Z in condition I is preferably 0.40 to 1.60; Z in condition II is preferably 0.42 to 1.70; Z in condition III is preferably 0.45 to 1.80; and Z in condition IV is preferably 0.38 to 1.80.

[0145] Alcohol composition B can be manufactured under the conditions shown in Table 2, including DS, MS, X, Y, and Z. In Table 2, the water-soluble cellulose ether used in condition I is MC, and the water-soluble cellulose ether used in conditions II to IV is HPMC.

[0146] Table 2

[0147] conditions DS MS X Y Z I 1.0～2.2 0.00 30.0～68.0 10～70 0.25～2.40 II 1.5～2.2 0.15～0.35 30.0～88.0 10～70 0.23～2.60 III 1.5～2.2 0.10～0.21 30.0～75.0 10～70 0.22～2.30 IV 1.0～1.8 0.10～0.30 30.0～70.0 10～70 0.21～2.10

[0148] From the viewpoint of the solubility of HPMC in the alcohol composition and its thickening properties imparted to the alcohol composition, the DS and MS of the HPMC used in conditions II to IV are preferably in a specified relationship. For example, the HPMC used in condition II preferably has a DS of 1.60 to 2.10 and an MS of 0.17 to 0.30; the HPMC used in condition III preferably has a DS of 1.60 to 2.10 and an MS of 0.12 to 0.21; and the HPMC used in condition IV preferably has a DS of 1.20 to 1.70 and an MS of 0.17 to 0.30.

[0149] Furthermore, since the alcohol composition B tends to have excellent workability and solubility of water-soluble cellulose ethers, Z is preferably 0.51 to 1.83 in condition I; preferably 0.42 to 2.30 in condition II; preferably 0.45 to 2.00 in condition III; and preferably 0.45 to 1.80 in condition IV.

[0150] Alcohol composition C can be manufactured under the conditions shown in Table 3, including DS, MS, X, Y, and Z. In Table 3, the water-soluble cellulose ether used in condition I is MC, and the water-soluble cellulose ether used in conditions II to IV is HPMC.

[0151] Table 3

[0152] conditions DD MS X Y Z I 1.0～2.2 0.00 60.0～68.0 10～70 0.24～2.20 II 1.5～2.2 0.10～0.35 83.0～88.0 10～70 0.23～1.90 III 1.5～2.2 0.10～0.21 68.0～75.0 10～70 0.22～2.00 IV 1.0～1.8 0.10～0.30 60.0～70.0 10～70 0.21～2.00

[0153] From the viewpoint of the solubility of HPMC in the alcohol composition and its thickening properties imparted to the alcohol composition, the DS and MS of the HPMC used in conditions II to IV are preferably in a specified relationship. For example, for the HPMC used in condition II, the DS is preferably 1.60 to 2.10 and the MS is preferably 0.17 to 0.30; for the HPMC used in condition III, the DS is preferably 1.60 to 2.10 and the MS is preferably 0.12 to 0.21; and for the HPMC used in condition IV, the DS is preferably 1.20 to 1.70 and the MS is preferably 0.17 to 0.30.

[0154] Furthermore, since an alcohol composition C with excellent workability and solubility of water-soluble cellulose ethers is tended to be obtained as a result, Z in condition I is preferably 0.54 to 1.78; Z in condition II is preferably 0.47 to 1.82; Z in condition III is preferably 0.45 to 1.80; and Z in condition IV is preferably 0.45 to 1.80.

[0155] <Uses of alcohol compositions>

[0156] The use of the alcohol composition of one aspect of the present invention is not particularly limited. Since it can contain ethanol and / or isopropanol in high concentrations, it is preferably used for disinfection purposes, and more preferably for hand disinfection purposes. Because a gel form with suitable viscosity can be obtained by measuring the loss tangent (tanδ) of alcohol composition A and alcohol composition C in one aspect of the present invention at 20°C, a frequency of 1 Hz, and a deformation of 0.1%, it can be used as a gel-like disinfectant alcohol composition in various situations such as daily life and medical settings.

[0157]

Example

[0158] The present invention will be further described in detail below through embodiments and comparative examples. However, the present invention is not limited to these embodiments or comparative examples.

[0159] <Physical Property Evaluation>

[0160] [HPMC and the viscosity of MC]

[0161] For the viscosity of water-soluble cellulose ethers of HPMC and MC, the viscosity of a 2.0% by mass aqueous solution at 20°C was determined using a single-cylinder rotational viscometer according to the "Viscosity Measurement Method" of the General Test Method described in the 17th revised edition of the Japanese Pharmacopoeia.

[0162] [Viscosity of alcohol compositions]

[0163] The viscosity of the alcohol composition was measured using a single-cylinder viscometer (Tokyo Keiki Co., Ltd., "DVM-BII", rotor No. 2-4), as the value measured after 120 seconds at 30°C at 20°C. For viscometers exceeding 20,000 mPa·s, a type B viscometer (Tokyo Keiki Co., Ltd., "B8H", rotor No. 5) was used, and the value measured after 120 seconds at 20°C at 20°C.

[0164] [Loss Tangent]

[0165] For alcohol compositions, the loss tangent was measured using a rheometer “MCR-301” (manufactured by Anton Paar) as follows.

[0166] The sample measuring section of the rheometer was preheated to 25°C. The alcohol composition was injected into the mark (25 ml) of a CC27 measuring cup (a cylindrical aluminum container with a diameter of 30 mm and a height of 80 mm). For the alcohol composition injected into the measuring cup, deformation was applied within the range of 0.01% to 100.0% using a pump cylinder (26.7 mm in diameter and 40.0 mm in height: CC27), and the viscoelasticity was measured. The measuring section was kept constant at 25°C. The measured viscoelastic value was taken as the loss tangent.

[0167] [Light transmittance]

[0168] For alcohol compositions with a temperature setting of 20°C, the transmittance was measured using a photoelectric colorimeter "PC-50" (manufactured by KOTAKI) through a 720nm filter and a 20mm cuvette.

[0169] [Liquid dripping]

[0170] Place the alcohol composition into a dispenser container (“200ml pump bottle”, 3mm diameter, FRCOLOR Corporation), and visually confirm the liquid-free properties when dispensed as a gel three times consecutively. Evaluate the liquid droplet according to the following evaluation criteria.

[0171] Evaluation Criteria:

[0172] - No liquid dripping

[0173] +: When pressed 3 times, liquid drips when pressed 1 time.

[0174] ++: When pressed 3 times, liquid drips when pressed 2 times.

[0175] +++: When pressed 3 times, liquid drips.

[0176] Sensory evaluation

[0177] [Applying feel]

[0178] The application feel was confirmed by five reviewers specializing in evaluating the user experience of alcohol-based compositions, using sensory evaluation as follows.

[0179] That is, each reviewer placed 5 ml of the alcohol composition on the back of their hand and scored the overall feel of the product when applied to the hand according to the following evaluation criterion-a. The score with the highest number of responses was then used as the application feel. However, for compositions with a loss tangent exceeding 1.0 and a transmittance of 65.0% or higher, since they do not have an effect on the application feel, other evaluation criteria were established (evaluation criterion-b).

[0180] Evaluation Criteria - a

[0181] 3: It stretches well, has no stickiness, and feels relatively dry.

[0182] 2: Spreads well and feels moist when applied.

[0183] 1: It has a sticky feeling

[0184] 0: Poor spreadability, or liquid overflows from the hands and is difficult to apply.

[0185] Evaluation Benchmark - b

[0186] 2: Does not spill from hands, can be applied and is less sticky.

[0187] 1. It does not overflow from the hand; it can be applied topically.

[0188] 0: Liquid spills from hands and is difficult to apply.

[0189] <Method for manufacturing alcohol compositions>

[0190] [Materials Used]

[0191] HPMC and MC used the samples listed in Table 4 (all manufactured by Shin-Etsu Chemical Co., Ltd.). Alcohols used were ethanol (manufactured by Fujifilm and Koichi Chemical Co., Ltd.), isopropanol (manufactured by Kishida Chemical Co., Ltd.), and glycerol (manufactured by Kishida Chemical Co., Ltd.). Purified water was used.

[0192] Table 4

[0193]

[0194] [Example 1]

[0195] Accurately weigh 20.0 g of ethanol as the first alcohol into a 200 ml beaker, add 2.0 g of MC (CE-1), and stir for 2 minutes using a magnetic stirrer (Azov Corporation, "HS-360", 200 rpm to 300 rpm) to form a homogeneous dispersion. Then, while maintaining stirring, add 28.0 g of pure water at 20°C to the resulting dispersion to dissolve the MC and obtain a solution. Add 50.0 g of ethanol as the second alcohol to the resulting solution and homogenize for 4 minutes using a small homogenizer (Azov Corporation, "AHG-160D", 5,000 rpm) to obtain the alcohol composition of Example 1.

[0196] [Examples 2-36]

[0197] Except for the types and amounts of alcohols and samples shown in Table 5, the alcohol compositions of Examples 2-24 and 26-36 were prepared in the same manner as in Example 1.

[0198] [Example 37]

[0199] Accurately weigh 20.0 g of ethanol into a 200 ml beaker, add 2.0 g of hydroxypropyl methylcellulose (HPMC), and stir for 2 minutes using a magnetic stirrer (Azov, HS-360, 200-300 rpm) to form a homogeneous dispersion. Then, while maintaining stirring, add 26.0 g of pure water at 20°C to the dispersion to dissolve the HPMC. Add 50.0 g of ethanol and 2.0 g of glycerol to the resulting solution, and homogenize at 5,000 rpm for 4 minutes using a small homogenizer (Azov, AHG-160D) to obtain the alcohol composition.

[0200] [Reference Example 1]

[0201] Carboxyvinyl polymer (2.0 g) was added to pure water (98.0 g) and dissolved using a homogenizer (Azovn HM-310) to prepare a 2% aqueous solution of carboxyvinyl polymer (carbomer).

[0202] An alcohol composition was prepared by measuring 70.0 g of ethanol, 9.98 g of pure water at 20°C, and 20.0 g of 2% carbomer aqueous solution in a 200 ml beaker, and then processing the solution at 5,000 rpm for 4 minutes using a small homogenizer (AHG-160D, manufactured by Azov Corporation). Triethanolamine (0.02 g) was then added to the resulting solution to adjust the pH to 6-8.

[0203] <Evaluation Results>

[0204] The results of evaluating viscosity, loss tangent, transmittance, liquid dripping, and spreadability for the alcohol compositions of Examples 1-37 are shown in Tables 5 and 6.

[0205] [Evaluation Results of Alcohol Composition A]

[0206] Even at high concentrations of 60% or more, alcohol compositions with appropriate viscosity can be obtained when filling containers and when applied to the skin.

[0207] The alcohol compositions obtained through Examples 1-11, 13, 15, 21-24, 26-29, and 34-36, due to their loss tangent being 1.0 or less, exhibited a good gel-like structure because the contribution of elasticity outweighed the contribution of viscosity. As a result, no liquid dripped from the container, and the liquid did not spill from the hand even when held in it, allowing for easy application. Furthermore, those with a loss tangent of 1.00 or less generally spread well, were easy to apply, had little stickiness, and provided a pleasant user experience.

[0208] [Evaluation results of alcohol composition B]

[0209] Even at high concentrations of 60% or more, alcohol compositions with high transparency can be obtained.

[0210] The alcohol compositions obtained through Examples 4, 5, 8, 12-25, 27, 28, 30-34, 36, and 37 exhibit high transparency and a pleasant appearance. Although some liquid drips from the container, it is within usable limits. Furthermore, those with a loss tangent exceeding 1.00 have a weaker gel-like feel and a slippery, melt-like consistency, providing a moist application when spread on the hand.

[0211] [Evaluation results of alcohol composition C]

[0212] Even at a high concentration of 60%, alcohol compositions with high transparency and appropriate viscosity when filled into containers and applied to the skin can be obtained.

[0213] The alcohol compositions obtained through Examples 4, 5, 8, 13, 15, 21-24, 27, 28, 34, and 36 exhibit high transparency and a pleasant appearance. Because the loss tangent is below 1.0, the contribution of elasticity outweighs the contribution of viscosity, maintaining a good gel form. As a result, no liquid drips from the container, and the liquid does not overflow even when held in the hand, allowing for easy application. Furthermore, those with a loss tangent below 1.00 generally spread well, are easy to apply, have low stickiness, and offer a good user experience.

[0214] The alcohol composition of Example 25 exhibits high transparency and a pleasant appearance. Furthermore, although most of the loss tangents of the alcohol composition of Example 25 exceed 1.00, no liquid drips from the container, and it does not overflow even when held in the hand, thus allowing for easy application. The alcohol composition of Example 25 spreads well, is easy to apply, and provides a moisturizing feel with minimal stickiness and a pleasant user experience.

[0215] Furthermore, alcohol compositions A, B, and C all exhibited similar viscosity changes after standing at room temperature for one week, as the water-soluble cellulose ethers they contained were well dissolved. Additionally, the alcohol composition of Reference Example 1, which contained carbomer, readily soluble in ethanol, as a thickener, also showed almost no change in viscosity after standing at room temperature for one week, compared to its initial viscosity. These results indicate that while cellulose ethers are poorly soluble in alcohols, they are well soluble in alcohol compositions A, B, and C.

[0216] Table 5

[0217]

[0218] Table 6

[0219]

[0220] Industrial availability

[0221] One aspect of the alcohol composition of the present invention can be used in the medical field, personal care field, etc., and is industrially manufactured as an alcohol composition with a desired viscosity and alcohol concentration, and can be widely used in a variety of general applications.

Claims

1. An alcohol composition comprising: 60.0 to 93.0 parts by weight of at least one alcohol selected from ethanol and isopropanol; 3.0 to 39.9 parts by weight of water; and 0.1 to 4.0 parts by weight of at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose and methylcellulose; The loss tangent of the alcohol composition measured at 20°C, 1 Hz, and with a deformation of 0.1%, was 0.10–1.

00. The alcohol composition does not contain hydroxyethyl cellulose or carboxyvinyl polymers; The water-soluble cellulose ether is at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose with a molar substitution number of 0.10 to 0.60 of hydroxypropoxy and a degree of substitution of methoxy with 1.20 to 2.20, and methylcellulose with a degree of substitution of methoxy with 1.20 to 2.

20.

2. The alcohol composition according to claim 1, wherein the viscosity of a 2.0% by mass aqueous solution of the alcohol composition at 20°C, as measured by a viscometer, is 2,500 mPa•s or higher.

3. An alcohol composition comprising: 40.0 to 88.0 parts by weight of at least one alcohol selected from ethanol and isopropanol; 8.0 to 59.9 parts by weight of water; and 0.1 to 4.0 parts by weight of at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose and methylcellulose; The transmittance of the alcohol composition is 65.0% or higher; The alcohol composition does not contain hydroxyethyl cellulose or carboxyvinyl polymers; The water-soluble cellulose ether is at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose with a molar substitution number of 0.10 to 0.60 of hydroxypropoxy and a degree of substitution of methoxy with 1.20 to 2.20, and methylcellulose with a degree of substitution of methoxy with 1.20 to 2.

20.

4. The alcohol composition according to claim 3, wherein the viscosity of a 2.0% by mass aqueous solution of the alcohol composition at 20°C, as measured by a viscometer, is 1,500 mPa•s or higher.

5. An alcohol composition comprising: 60.0 to 88.0 parts by weight of at least one alcohol selected from ethanol and isopropanol; 8.0 to 39.9 parts by weight of water; and 0.1 to 4.0 parts by weight of at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose and methylcellulose; The loss tangent of the alcohol composition measured at 20°C, 1 Hz, and with a deformation of 0.1%, is 0.10–1.00, and the transmittance is 65.0% or higher. The alcohol composition does not contain hydroxyethyl cellulose or carboxyvinyl polymers; The water-soluble cellulose ether is at least one water-soluble cellulose ether selected from hydroxypropyl methylcellulose with a molar substitution number of 0.10 to 0.60 of hydroxypropoxy and a degree of substitution of methoxy with 1.20 to 2.20, and methylcellulose with a degree of substitution of methoxy with 1.20 to 2.

20.

6. The alcohol composition according to claim 5, wherein the viscosity of a 2.0% by mass aqueous solution of the alcohol composition at 20°C, as measured by a viscometer, is 2,500 mPa•s or higher.

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