Immune microbubble complex and its uses

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By conjugating immune checkpoint inhibitory antibodies on the surface of microvesicles and combining with high-intensity ultrasound treatment, immune microvesicles complexes were developed, solving the problems of reduced cancer immunotherapy effects and limited diagnostic agent effects, and achieving efficient cancer diagnosis and treatment.

CN114340682BActive Publication Date: 2025-07-25IMGT

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Patent Information

Application Number: CN202080062051.0
Authority / Receiving Office: CN · China
Patent Type: Patents(China)
Current Assignee / Owner
Priority Date: 2019-09-02
Filing Date: 2020-09-01
Publication Date: 2025-07-25
Estimated Expiration: 2040-09-01

Application Information

Patent Timeline

02 Sep 2019

Priority

01 Sep 2020

Application

CN202080062051.0

25 Jul 2025

Publication

CN114340682B

IPC: A61K47/69; A61K39/395; A61K41/00; A61K49/00; A61K49/18; A61K49/22; A61P35/00

CPC: A61K41/00; A61P35/00; A61K2039/505; A61K47/6925; A61K41/0028; A61K49/223; A61K49/221; A61K39/39558

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Application Domain

Sonopheresis Powder delivery

Technology Topics

High-intensity focused ultrasound Immunopotentiation

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AI Technical Summary

Technical Problem

Existing cancer immunotherapy methods have the problem of cancer cells producing interfering antibodies that lead to decreased therapeutic effects and systemic circulation side effects, and traditional diagnostic agents have limited effectiveness in cancer diagnosis and treatment.

Method used

Develop an immune microvesicle complex to promote immune response, activate T cells, and enhance anti-tumor effects by conjugating immune checkpoints on the surface of the microvesicle and combining with high-intensity focus ultrasound treatment.

Benefits of technology

It improves the efficiency of antibody delivery, enhances the cancer diagnosis and treatment effect, reduces side effects, and achieves efficient diagnosis and treatment of cancer.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present invention relates to an immunomicrobubble complex and its uses. The immunomicrobubble complex (IMC) according to the present invention comprises microbubbles conjugated with an antibody, wherein the microbubbles have excellent stability and excellent antibody binding strength, and it has been confirmed that when the immunomicrobubble complex is treated with high-intensity focused ultrasound (HIFU), the anti-tumor effect is significantly enhanced and an immune-enhancing effect is exhibited. Therefore, the immunomicrobubble complex according to the present invention is expected to improve the delivery efficiency of the conjugated antibody and can be used for the diagnosis and treatment of cancer, and exhibits various functions in the field of immunotherapy, including a contrast effect, improvement of half-life, improvement of drug delivery, lymphocyte concentrating effect, cancer immunotherapy, and ultrasound-induced immunotherapy.

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