Dose Rate Intensity Modulation Method, Device, Computer Equipment and Storage Medium

Abstract

Embodiments of the present invention provide a dose rate intensity modulation method, device, computer device, and storage medium, which relate to the field of intensity modulated radiotherapy. In the embodiments of the present invention, first, the current actual dose, the current target dose, and the current pulse frequency are obtained, where the current pulse frequency is used to characterize the dose rate of the radiation beam emitted by the radiation source device; then, according to the current actual dose, the current target dose, and the current pulse frequency, the output pulse frequency is determined; finally, the dose rate of the radiation beam emitted by the radiation source device is updated according to the output pulse frequency. The embodiments of the present invention determine the output pulse frequency based on the current actual dose, the current target dose, and the current pulse frequency, and update the dose rate of the radiation beam emitted by the radiation source device to continue irradiating the target area, so that during the radiotherapy process, the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan is within the acceptable range.

Description

Technical Field

[0001] The present invention relates to the field of radiotherapy, and in particular, to a dose rate intensity modulation method, device, computer device, and storage medium. Background Art

[0002] Volumetric Modulated Arc Therapy (VMAT) is a commonly used radiotherapy technique. By combining the radiation source device with the gantry movement, while the gantry rotates around the patient, the dose rate and the radiation field shape of the radiation beam emitted by the radiation source device are changed to continuously irradiate the tumor target area. The irradiations at various angles are integrated and superimposed to form a dose distribution with better conformity, such that the dose received by the organs at risk around the target area is low, while the tumor target area receives a large dose of irradiation, which can reduce the related side effects caused by radiotherapy.

[0003] In order to improve the Gamma passing rate of the case execution, a tumor target area can be treated in segments. Within each small segment, the dose rate and the radiation field shape of the radiation beam emitted by the radiation source device remain unchanged. However, due to reasons such as modulator pulse loss or microwave system arcing, there is an error between the actual dose obtained by integrating and superimposing the irradiations of the target area within each small segment and the target dose in the treatment plan, resulting in the actual treatment result deviating from the result specified in the treatment plan. Summary of the Invention

[0004] In order to overcome the deficiencies of the prior art, embodiments of the present invention provide a dose rate intensity modulation method, device, computer device, and storage medium.

[0005] The technical solutions adopted in the embodiments of the present invention are as follows:

[0006] In a first aspect, embodiments of the present invention provide a dose rate intensity modulation method, the method comprising:

[0007] Obtain a current actual dose, a current target dose, and a current pulse frequency, where the current pulse frequency is used to characterize the dose rate of the radiation beam emitted by the radiation source device;

[0008] Determine an output pulse frequency according to the current actual dose, the current target dose, and the current pulse frequency;

[0009] Update the dose rate of the radiation beam emitted by the radiation source device according to the output pulse frequency.

[0010] In a possible implementation manner, the determining an output pulse frequency according to the current actual dose, the current target dose, and the current pulse frequency includes:

[0011] Calculate a dose difference based on the current actual dose and the current target dose;

[0012] Determine a pulse frequency compensation value based on the dose difference and the current pulse frequency;

[0013] Adjust the current pulse frequency according to the pulse frequency compensation value to obtain an output pulse frequency.

[0014] In a possible implementation, the determining a pulse frequency compensation value based on the dose difference and the current pulse frequency includes:

[0015] If the dose difference is not less than a preset threshold, determine a pulse frequency compensation value based on the dose difference, the single - pulse dose, and the current pulse frequency.

[0016] In a possible implementation, the determining a pulse frequency compensation value based on the dose difference, the single - pulse dose, and the current pulse frequency includes:

[0017] Determine a reference compensation value based on the dose difference, the single - pulse dose, a first period, and a second period;

[0018] Determine a first correction coefficient based on the dose difference and a first preset parameter;

[0019] Determine a second correction coefficient based on the reference compensation value and a second preset parameter;

[0020] Dynamically adjust the reference compensation value based on the first correction coefficient, the second correction coefficient, and the current pulse frequency to obtain a pulse frequency compensation value.

[0021] In a possible implementation, the dynamically adjusting the reference compensation value based on the first correction coefficient, the second correction coefficient, and the current pulse frequency to obtain a pulse frequency compensation value includes:

[0022] Determine a first threshold value and a second threshold value based on the first correction coefficient, the second correction coefficient, and the current pulse frequency;

[0023] If the reference compensation value is less than the first threshold value, use the first threshold value as the pulse frequency compensation value;

[0024] If the reference compensation value is greater than or equal to the first threshold value and less than or equal to the second threshold value, use the reference compensation value as the pulse frequency compensation value;

[0025] If the reference compensation value is greater than the second threshold value, use the second threshold value as the pulse frequency compensation value.

[0026] In a possible implementation, the method further includes:

[0027] Performing output limitation on the output pulse frequency according to a third preset parameter.

[0028] In a possible implementation, the third preset parameter includes a maximum dose rate, a pulse frequency conversion coefficient, a pulse frequency tolerance value, and a maximum output pulse frequency. Performing output limitation on the output pulse frequency according to the third preset parameter includes:

[0029] If the output pulse frequency is greater than the ratio of the maximum dose rate to the pulse frequency conversion coefficient, then using the calculation result obtained based on the maximum dose rate, the pulse frequency conversion coefficient, the pulse frequency tolerance value, and the maximum output pulse frequency as the output pulse frequency.

[0030] In a second aspect, an embodiment of the present invention further provides a dose rate intensity modulation device, and the device includes:

[0031] An acquisition module, configured to acquire a current actual dose, a current target dose, and a current pulse frequency, where the current pulse frequency is used to characterize the dose rate of a radiation beam emitted by a radiation source device;

[0032] A determination module, configured to determine an output pulse frequency according to the current actual dose, the current target dose, and the current pulse frequency;

[0033] An update module, configured to update the dose rate of the radiation beam emitted by the radiation source device according to the output pulse frequency.

[0034] In a third aspect, an embodiment of the present invention provides a computer device, and the computer device includes a memory, a processor, and a radiation source device. The memory is used to store a computer program; the processor is configured to execute the method as described in the first aspect when calling the computer program.

[0035] In a fourth aspect, an embodiment of the present invention provides a computer-readable storage medium, on which a computer program is stored, and when the computer program is executed by a processor, the method as described in the first aspect is implemented.

[0036] Compared with the prior art, a dose rate intensity modulation method, device, computer device, and storage medium provided by an embodiment of the present invention determine an output pulse frequency according to a current actual dose, a current target dose, and a current pulse frequency, and update the dose rate of the radiation beam emitted by a radiation source device according to the output pulse frequency to continue irradiating a target area, so that during the radiotherapy process, the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan is within an acceptable range. Description of the Drawings

[0037] To more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the accompanying drawings required in the embodiments. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as limiting the scope. For those of ordinary skill in the art, without creative efforts, other related drawings can also be obtained based on these drawings.

[0038] Figure 1 Flowchart of a dose rate intensity modulation method provided by an embodiment of the present invention;

[0039] Figure 2 Flowchart of a method for determining the output pulse frequency provided by an embodiment of the present invention;

[0040] Figure 3 Another flowchart of a method for determining the output pulse frequency provided by an embodiment of the present invention;

[0041] Figure 4 Function relationship diagram of a first correction coefficient and a dose difference provided by an embodiment of the present invention;

[0042] Figure 5 Function relationship diagram of a second correction coefficient and a reference compensation value provided by an embodiment of the present invention;

[0043] Figure 6 Another flowchart of a method for determining the output pulse frequency provided by an embodiment of the present invention;

[0044] Figure 7 Block diagram of a dose rate intensity modulation device provided by an embodiment of the present invention;

[0045] Figure 8 Structural schematic block diagram of a computer device provided by an embodiment of the present invention.

[0046] Icons: 100 - Dose rate intensity modulation device; 101 - Acquisition module; 102 - Determination module; 103 - Update module; 200 - Computer device; 210 - Memory; 220 - Processor; 230 - Radiation source device. Detailed implementation manners

[0047] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. Usually, the components of the embodiments of the present invention described and shown in the accompanying drawings here can be arranged and designed in various different configurations.

[0048] Accordingly, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the scope of protection of the present invention.

[0049] It should be noted that like reference numerals and letters denote like items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0050] In the description of the present invention, it should be noted that if terms such as "upper", "lower", "inner", "outer", etc. are used to indicate the orientation or positional relationship, it is based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the inventive product is usually placed during use. This is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation of the present invention.

[0051] In addition, terms such as "first", "second", etc. are only used for distinguishing descriptions and should not be construed as indicating or implying relative importance.

[0052] It should be noted that the features in the embodiments of the present invention can be combined with each other without conflict.

[0053] Radiation therapy is a technique for treating tumors using high-energy rays generated by radiation source devices. Radiation therapy equipment is equipment that uses atomic nuclei or artificial devices to generate rays for treating tumors. For example, a cobalt-60 therapy machine uses cobalt-60 as a radiation source and uses γ rays to kill cancer cells to treat tumors; a medical electron linear accelerator is a device that uses a microwave electric field to accelerate electrons along a straight line to a higher energy for medical clinical applications.

[0054] Treatment planning design is an important link in the radiation therapy process. It refers to the whole process of determining a treatment plan, which can be understood as a computer controlling the radiation therapy equipment to arrange appropriate radiation fields according to the outer contour of the patient's treatment site, the contours of target areas, important tissues and organs, and the density of relevant tissues input, including dose calculation using radiation field baffles or tissue compensators, etc., to obtain the required dose distribution. The dose detection system is composed of a dose monitoring ionization chamber and a dose detection circuit, and is usually installed in the radiation head of the radiation therapy equipment. The computer can obtain the implementation situation of the treatment dose through the dose detection system.

[0055] Existing radiotherapy techniques include three-dimensional conformal radiotherapy (3D-CRT), intensity modulated radiotherapy (IMRT), and volumetric modulated arc therapy (VMAT). Among them, VMAT has the characteristics of better dose distribution conformity, more accurate dose, lower radiation dose to critical organs around the target area, and high-dose irradiation to the tumor target area. Therefore, it can significantly improve the efficiency of radiotherapy and reduce related side effects. Currently, it is mainly used for small target area cases, while for super-large tumors or systemic lesions, fractional or segmented treatment is required.

[0056] For the VMAT segmented treatment of the tumor target area, within each small segment, the dose rate and the field shape of the radiation beam emitted by the radiation source device remain unchanged. Compared with the non-segmented VMAT treatment method, although it can improve the Gamma passing rate of the medical record, there is a certain difference between the actual dose obtained by integrating and superimposing the irradiation of each small segment to the target area and the target dose in the treatment plan. Due to reasons such as modulator pulse loss or microwave system arcing, the above difference will be further amplified, resulting in the final treatment effect not meeting the requirements of the treatment plan designer.

[0057] In view of this, the embodiments of the present invention provide a dose rate intensity modulation method, so that during the radiotherapy process, the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan is within an acceptable range.

[0058] Please refer to Figure 1 , Figure 1 which is a flowchart of a dose rate intensity modulation method provided by the embodiments of the present invention. The method includes steps S101 to S103.

[0059] Step S101, obtaining the current actual dose, the current target dose, and the current pulse frequency, where the current pulse frequency is used to characterize the dose rate of the radiation beam emitted by the radiation source device.

[0060] In an embodiment of the present invention, the pulse frequency refers to the number of pulses that make up the radiation beam emitted by the radiation source device per unit time. Generally, the dose of a single pulse is approximately 0.1 MU / pulse. The pulse frequency can be used to characterize the dose of the radiation beam emitted by the radiation source device per unit time, that is, the dose rate. It can be understood that the current pulse frequency reflects the dose rate of the radiation beam emitted by the radiation source device at the current moment. The current actual dose refers to the actual result obtained by integrating and superimposing the irradiation dose rates of each small segment in the target area up to the current moment. The current target dose refers to the dose that should be achieved by integrating and superimposing the irradiation received by the target area up to the current moment. Among them, the current pulse frequency and the current actual dose can be obtained through the dose detection system installed in the radiation source device, and the current target dose can be obtained from the treatment plan according to the treatment site of the patient.

[0061] Step S102: Determine the output pulse frequency according to the current actual dose, the current target dose, and the current pulse frequency.

[0062] In an embodiment of the present invention, the current actual dose can characterize the actual radiotherapy effect, while the current target dose characterizes the radiotherapy result specified in the treatment plan. According to the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan, based on the current pulse frequency, the pulse frequency of the radiation beam emitted by the radiation source device is determined, that is, the output pulse frequency.

[0063] Step S103: Update the dose rate of the radiation beam emitted by the radiation source device according to the output pulse frequency.

[0064] In an embodiment of the present invention, by adjusting the pulse frequency of the radiation beam emitted by the radiation source device to the output pulse frequency, the dose rate of the radiation beam is updated and the target area is continuously irradiated, so as to gradually narrow the gap between the actual radiotherapy effect and the result specified in the treatment plan, and make the deviation degree between the two within an acceptable range.

[0065] The above method provided by the embodiment of the present invention has the beneficial effect that, according to the current actual dose, the current target dose, and the current pulse frequency, the output pulse frequency is determined to update the dose rate of the radiation beam emitted by the radiation source device to continue irradiating the target area, so that during the radiotherapy process, the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan is within the acceptable range.

[0066] Based on Figure 1 , an embodiment of the present invention provides a specific implementation manner for determining the output pulse frequency. Please refer to Figure 2 , Figure 2 is a flowchart of a method for determining the output pulse frequency provided by an embodiment of the present invention. Step S102 includes sub-steps S102-1 to S102-3.

[0067] Sub-step S102-1: Calculate the dose difference according to the current actual dose and the current target dose.

[0068] In the embodiment of the present invention, the dose difference is the absolute value of the result of subtracting the current target dose from the current actual dose, and the magnitude of its value characterizes the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan.

[0069] Sub-step S102-2: Determine the pulse frequency compensation value according to the dose difference and the current pulse frequency.

[0070] In the embodiment of the present invention, the pulse frequency compensation value refers to the change amount of the pulse frequency of the radiation beam emitted by the radiation source device in order to make the actual radiotherapy effect not deviate from the result specified in the treatment plan, and its magnitude depends on the dose difference and the current pulse frequency.

[0071] Sub-step S102-3: Adjust the current pulse frequency according to the pulse frequency compensation value to obtain the output pulse frequency.

[0072] In the embodiment of the present invention, the pulse frequency compensation value, the current pulse frequency and the output pulse frequency satisfy the formula PRF set =PFR n -PRF Delta where PRF n is the current pulse frequency, PRF Delta is the pulse frequency compensation value, and PRF set is the output pulse frequency. Since the pulse frequency compensation value may be positive, negative or zero, the output pulse frequency may be greater than the current pulse frequency, or may be less than or equal to the current pulse frequency.

[0073] The specific implementation manner of the above step S102 has the beneficial effect that the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan is characterized by the dose difference between the current actual dose and the current target dose, and then the pulse frequency compensation value is determined, and the current pulse frequency is adjusted to obtain the output pulse frequency.

[0074] Based on Figure 2 , the embodiment of the present invention provides a specific implementation manner for determining the pulse frequency compensation value. Please refer to Figure 3 , Figure 3 which is another method flowchart for determining the output pulse frequency provided by the embodiment of the present invention. Sub-step S102-2 further includes sub-steps S102-2-1 to S102-2-3.

[0075] Sub-step S102-2-1: Determine whether the dose difference is less than a preset threshold.

[0076] In the embodiment of the present invention, the preset threshold is the upper limit value of the dose difference, which represents the acceptable range of the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan. If the dose difference is less than the preset threshold, sub-step S102-2-2 is executed; if the dose difference is not less than the preset threshold, sub-step S102-2-3 is executed.

[0077] Sub-step S102-2-2: If the dose difference is less than the preset threshold, set the pulse frequency compensation value to 0.

[0078] In the embodiment of the present invention, when the dose difference is less than the preset threshold, the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan is within the acceptable range. At this time, it is not necessary to update the dose rate of the radiation beam emitted by the radiation source device, so the pulse frequency compensation value is set to 0.

[0079] Sub-step S10-2-3: If the dose difference is not less than the preset threshold, determine the pulse frequency compensation value according to the dose difference, the single-pulse dose, and the current pulse frequency.

[0080] In the embodiment of the present invention, when the dose difference is not less than the preset threshold, the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan has exceeded the acceptable range. At this time, it is necessary to update the dose rate of the radiation beam emitted by the radiation source device.

[0081] The specific implementation method of the above sub-step S102-2 has the beneficial effect that by setting a preset threshold for the dose difference to determine whether the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan is acceptable, and then determining the pulse frequency compensation value.

[0082] Specifically, the implementation process of sub-step S102-2-3 is as follows:

[0083] Sub-step S102-2-3-1: Determine the reference compensation value according to the dose difference, the single-pulse dose, the first cycle, and the second cycle.

[0084] In the embodiment of the present invention, the first cycle and the second cycle together determine the time interval between every two executions of the dose rate intensity modulation method provided in the present embodiment. The first cycle refers to the time required for the radiation source device to rotate a certain angle each time, and the second cycle refers to the number of rotations of the radiation source device. For example, if the radiation source device needs 10 ms to rotate 0.2 degrees each time and rotates 10 times, it has rotated a total of 2 degrees and taken 100 ms. Therefore, the dose rate intensity modulation method provided in the present embodiment is executed every 100 ms.

[0085] In the embodiment of the present invention, the dose difference, the single-pulse dose, the first cycle, the second cycle, and the reference compensation value satisfy the following formula:

[0086]

[0087] Among them, ΔIntegralDose is the dose difference, DPP is the single-pulse dose, with the unit of MU / pulse, TaskCycle is the first cycle, prfCatchCycle is the second cycle, and ΔPRF is the reference compensation value.

[0088] Sub-step S102-2-3-2: Determine the first correction coefficient according to the dose difference and the first preset parameter.

[0089] In the embodiment of the present invention, the first correction coefficient is a piecewise function of the dose difference, and the first preset parameter serves as the basis for segmenting the piecewise function, specifically satisfying the following formula:

[0090]

[0091] Among them, ΔIntegralDose is the dose difference, D1, D2, R1, and R2 are the first preset parameters, and a is the first correction coefficient.

[0092] As a specific implementation manner, D1, D2, R1, and R2 can be set to 0.5, 1, 0.1, and 2 respectively. At this time, the piecewise function of the first correction coefficient with respect to the dose difference is as Figure 4 shown. When the dose difference is less than 0.5, the first correction coefficient is 0.1. When the dose difference is greater than or equal to 1, the first correction coefficient is 2. When the dose difference is in the interval [0.5, 1), the first correction coefficient is calculated according to the expression 3.8×(ΔIntegralDose - 0.5) + 0.1, that is, the value range of the first correction coefficient is the interval [0.1, 2].

[0093] Sub-step S102-2-3-3: Determine the second correction coefficient according to the reference compensation value and the second preset parameter.

[0094] In the embodiment of the present invention, the second correction coefficient is a piecewise function of the reference compensation value, and the second preset parameter serves as the basis for segmenting the piecewise function, specifically satisfying the following formula:

[0095]

[0096] Among them, ΔPRF is the reference compensation value, P1, P2, Q1, and Q2 are the second preset parameters, and b is the second correction coefficient.

[0097] As a specific implementation manner, P1, P2, Q1, and Q2 can be set to 20, 40, 1, and 2 respectively. At this time, the piecewise function of the second correction coefficient with respect to the reference compensation value is as Figure 5As shown, when the reference compensation value is less than 20, the second correction factor is 2; when the reference compensation value is greater than or equal to 40, the second correction factor is 1; when the reference compensation value is in the range [20, 40), the second correction factor is calculated according to the expression -0.05×(ΔPRF - 20) + 2, that is, the value range of the second correction factor is the range [1, 2].

[0098] Sub-step S102-2-3-4: Dynamically adjust the reference compensation value according to the first correction factor, the second correction factor and the current pulse frequency to obtain the pulse frequency compensation value.

[0099] In the embodiment of the present invention, in order to prevent the system from oscillating due to an excessive pulse frequency compensation value, the reference compensation value is dynamically adjusted by using the first correction factor, the second correction factor and the current pulse frequency.

[0100] The specific implementation process of the above sub-step S102-2-3 has the beneficial effect that the reference compensation value obtained based on the dose difference is dynamically adjusted by respectively determining the first correction factor and the second correction factor, so as to obtain a pulse frequency compensation value that eliminates system oscillation.

[0101] Further, the implementation process of sub-step S102-2-3-4 is as follows:

[0102] Sub-step S102-2-3-4a: Determine the first threshold value and the second threshold value according to the first correction factor, the second correction factor and the current pulse frequency;

[0103] Sub-step S102-2-3-4b: If the reference compensation value is less than the first threshold value, take the first threshold value as the pulse frequency compensation value;

[0104] Sub-step S102-2-3-4c: If the reference compensation value is greater than or equal to the first threshold value and less than or equal to the second threshold value, take the reference compensation value as the pulse frequency compensation value;

[0105] Sub-step S102-2-3-4a: If the reference compensation value is greater than the second threshold value, take the second threshold value as the pulse frequency compensation value.

[0106] The above implementation process satisfies the following formula:

[0107]

[0108] Where a is the first correction factor, b is the second correction factor, PRF n is the current pulse frequency, ΔPRF is the reference compensation value, PRF Delta is the pulse frequency compensation value, -a×b×PRF n is the first threshold value, that is, the pulse frequency compensation value PRFDelta The minimum value of a×b×PRF n is the second threshold value, i.e., the pulse frequency compensation value PRF Delta The maximum value of

[0109] Based on Figure 2 and Figure 3 , the embodiments of the present invention provide another specific implementation manner for determining the output pulse frequency. Please refer to Figure 6 , Figure 6 FIG.

[0110] Sub-step S102-4: Limit the output pulse frequency according to the third preset parameter.

[0111] In the embodiments of the present invention, the third preset parameter includes the maximum dose rate, the pulse frequency conversion coefficient, the pulse frequency tolerance, and the maximum output pulse frequency. When the radiation beam emitted by the radiation source device irradiates the target area, in order to ensure the safety of the patient, it is necessary to use the third preset parameter to limit the magnitude of the output pulse frequency.

[0112] Specifically, the implementation process of sub-step S102-4 is as follows:

[0113] Sub-step S102-4-1: Determine whether the output pulse frequency is greater than the ratio of the maximum dose rate to the pulse frequency conversion coefficient.

[0114] In the embodiments of the present invention, when the output pulse frequency is less than or equal to the ratio of the maximum dose rate to the pulse frequency conversion coefficient, the dose rate of the radiation beam emitted by the radiation source device can be directly updated using the output pulse frequency. If the output pulse frequency is greater than the ratio of the maximum dose rate to the pulse frequency conversion coefficient, then sub-step S102-4-2 is executed.

[0115] Sub-step S102-4-2: If the output pulse frequency is greater than the ratio of the maximum dose rate to the pulse frequency conversion coefficient, then use the calculation result obtained from the maximum dose rate, the pulse frequency conversion coefficient, the pulse frequency tolerance, and the maximum output pulse frequency as the output pulse frequency.

[0116] In the embodiments of the present invention, when the output pulse frequency is greater than the ratio of the maximum dose rate to the pulse frequency conversion coefficient, if the dose rate of the radiation beam emitted by the radiation source device is directly updated using the output pulse frequency at this time, it will cause harm to the patient's body. It is necessary to use the following formula based on the maximum dose rate, the pulse frequency conversion coefficient, the pulse frequency tolerance, and the maximum output pulse frequency to re-determine the output pulse frequency for updating the dose rate of the radiation beam emitted by the radiation source device.

[0117]

[0118] Among them, DoseRateMax is the maximum dose rate, PRFRatio is the pulse frequency conversion coefficient, PRFTolerace is the pulse frequency tolerance value, PRFMax is the maximum output pulse frequency, and PRF set is the output pulse frequency.

[0119] The specific implementation process of the above sub-step S102-4 has the beneficial effect that by judging whether the output pulse frequency is greater than the ratio of the maximum dose rate to the pulse frequency conversion coefficient, it is determined whether the output pulse frequency will threaten the safety of the patient.

[0120] In order to execute the corresponding steps in the above embodiments and each possible implementation manner, the following gives an implementation manner of a dose rate intensity modulation device 100. Please refer to Figure 7 , Figure 7 shows a block diagram of the dose rate intensity modulation device 100 provided by the embodiment of the present invention. It should be noted that for the dose rate intensity modulation device 100 provided by the embodiment of the present invention, its basic principle and the generated technical effects are the same as those of the above embodiments. For the sake of brief description, they are not mentioned in the embodiments of the present invention.

[0121] The dose rate intensity modulation device 100 includes an acquisition module 101, a determination module 102, and an update module 103.

[0122] The acquisition module 101 is used to acquire the current actual dose, the current target dose, and the current pulse frequency, and the current pulse frequency is used to characterize the dose rate of the radiation beam emitted by the radiation source device.

[0123] The determination module 102 is used to determine the output pulse frequency according to the current actual dose, the current target dose, and the current pulse frequency.

[0124] The update module 103 is used to update the dose rate of the radiation beam emitted by the radiation source device according to the output pulse frequency.

[0125] As a specific implementation manner, when the determination module 102 is used to determine the output pulse frequency according to the current actual dose, the current target dose, and the current pulse frequency, it is specifically further used to calculate the dose difference according to the current actual dose and the current target dose; determine the pulse frequency compensation value according to the dose difference and the current pulse frequency; and adjust the current pulse frequency according to the pulse frequency compensation value to obtain the output pulse frequency.

[0126] As a specific implementation, when determining module 102 is used to determine the pulse frequency compensation value according to the dose difference and the current pulse frequency, it is further specifically used to determine whether the dose difference is less than a preset threshold; if the dose difference is less than the preset threshold, the pulse frequency compensation value is set to 0; if the dose difference is not less than the preset threshold, the pulse frequency compensation value is determined according to the dose difference, the single-pulse dose, and the current pulse frequency.

[0127] As a specific implementation, when determining module 102 is used to determine the pulse frequency compensation value according to the dose difference, the single-pulse dose, and the current pulse frequency, it is further specifically used to determine a reference compensation value according to the dose difference, the single-pulse dose, the first period, and the second period; determine a first correction coefficient according to the dose difference and a first preset parameter; determine a second correction coefficient according to the reference compensation value and a second preset parameter; dynamically adjust the reference compensation value according to the first correction coefficient, the second correction coefficient, and the current pulse frequency to obtain the pulse frequency compensation value.

[0128] As a specific implementation, when determining module 102 is used to dynamically adjust the reference compensation value according to the first correction coefficient, the second correction coefficient, and the current pulse frequency to obtain the pulse frequency compensation value, it is further specifically used to determine a first threshold value and a second threshold value according to the first correction coefficient, the second correction coefficient, and the current pulse frequency; if the reference compensation value is less than the first threshold value, the first threshold value is used as the pulse frequency compensation value; if the reference compensation value is greater than or equal to the first threshold value and less than or equal to the second threshold value, the reference compensation value is used as the pulse frequency compensation value; if the reference compensation value is greater than the second threshold value, the second threshold value is used as the pulse frequency compensation value.

[0129] As a specific implementation, determining module 102 is further used to perform output limitation on the output pulse frequency according to a third preset parameter.

[0130] As a specific implementation, the third preset parameter includes a maximum dose rate, a pulse frequency conversion coefficient, a pulse frequency tolerance value, and a maximum output pulse frequency. When determining module 102 is used to perform output limitation on the output pulse frequency according to the third preset parameter, it is further specifically used to determine whether the output pulse frequency is greater than the ratio of the maximum dose rate to the pulse frequency conversion coefficient; if the output pulse frequency is greater than the ratio of the maximum dose rate to the pulse frequency conversion coefficient, the calculation result obtained according to the maximum dose rate, the pulse frequency conversion coefficient, the pulse frequency tolerance value, and the maximum output pulse frequency is used as the output pulse frequency.

[0131] Further, please refer to Figure 8 , Figure 8 which is a structural schematic diagram of a computer device 200 provided by an embodiment of the present invention. The computer device 200 may include a memory 210, a processor 220, and a radiation source device 230.

[0132] Among them, the processor 220 may be a general-purpose central processing unit (CPU), a microprocessor, an application-specific integrated circuit (ASIC), or one or more integrated circuits for controlling the execution of the program for the intensity-modulated dose rate method provided in the following method embodiments.

[0133] The memory 210 may be a ROM or other types of static storage devices that can store static information and instructions, a RAM or other types of dynamic storage devices that can store information and instructions, or may also be an electrically erasable programmable read-only memory (EEPROM), a compact disc read-only memory (CD-ROM), or other optical disc storage, optical disc storage (including compact discs, laser discs, optical discs, digital versatile discs, Blu-ray discs, etc.), magnetic disk storage media, or any other medium that can be used to carry or store the desired program code in the form of instructions or data structures and can be accessed by a computer, but is not limited thereto. The memory 210 may exist independently and be connected to the processor 220 through a communication bus. The memory 210 may also be integrated with the processor 220. Among them, the memory 210 is used to store machine-executable instructions for executing the solution of the present application. The processor 220 is used to execute the machine-executable instructions stored in the memory 210 to implement the foregoing method embodiments.

[0134] The radiation source device 230 may be an accelerator with an internal multi-leaf collimator (MLC), or a grid-controlled electron gun, or any other device that can emit a radiation beam with a variable radiation field and dose rate, but is not limited thereto. The radiation source device 230 may be connected to the processor 220 through a communication bus. When the processor 220 is used to execute the machine-executable instructions stored in the memory 210, it controls the radiation source device 230 to implement the foregoing method embodiments.

[0135] Since the computer device 200 provided in the embodiments of the present invention is another implementation form of the intensity-modulated dose rate method provided in the foregoing method embodiments, the technical effects that can be obtained therefrom can refer to the above method embodiments and will not be elaborated herein.

[0136] The embodiments of the present invention also provide a readable storage medium containing computer-executable instructions, and the computer-executable instructions can be used to perform related operations in the intensity-modulated dose rate method provided in the foregoing method embodiments when executed.

[0137] In summary, a dose rate intensity modulation method, device, computer device, and storage medium provided by an embodiment of the present invention first obtain a current actual dose, a current target dose, and a current pulse frequency, where the current pulse frequency is used to characterize the dose rate of a radiation beam emitted by a radiation source device; then determine an output pulse frequency according to the current actual dose, the current target dose, and the current pulse frequency; and finally, update the dose rate of the radiation beam emitted by the radiation source device according to the output pulse frequency, so that during radiotherapy, the deviation degree between the actual radiotherapy effect and the result specified in the treatment plan is within an acceptable range.

[0138] The above is only a specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by those skilled in the art within the technical scope disclosed by the present invention should be covered by the protection scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope of the claims.

Claims

1. A dose rate intensity modulation device, characterized in that, The device includes: An acquisition module, configured to acquire the current actual dose, the current target dose, and the current pulse frequency, where the current pulse frequency is used to characterize the dose rate of the radiation beam emitted by the radiation source device; A determination module, configured to: Calculate a dose difference according to the current actual dose and the current target dose; If the dose difference is not less than a preset threshold, determine a reference compensation value according to the dose difference, the single-pulse dose, the first period, and the second period; where the first period is the time required for the radiation source device to rotate a preset angle each time, and the second period is the number of rotations of the radiation source device; Determine a first correction coefficient according to the dose difference and a first preset parameter; where the first correction coefficient is a piecewise function of the dose difference, and the first preset parameter is the segmentation basis of the piecewise function of the dose difference; Determine a second correction coefficient according to the reference compensation value and a second preset parameter; where the second correction coefficient is a piecewise function of the reference compensation value, and the second preset parameter is the segmentation basis of the piecewise function of the reference compensation value; Dynamically adjust the reference compensation value according to the first correction coefficient, the second correction coefficient, and the current pulse frequency to obtain a pulse frequency compensation value; Adjust the current pulse frequency according to the pulse frequency compensation value to obtain an output pulse frequency; An update module, configured to update the dose rate of the radiation beam emitted by the radiation source device according to the output pulse frequency.

2. The device according to claim 1, characterized in that, When the determination module is configured to dynamically adjust the reference compensation value according to the first correction coefficient, the second correction coefficient, and the current pulse frequency to obtain a pulse frequency compensation value, it is further configured to: Determine a first threshold value and a second threshold value according to the first correction coefficient, the second correction coefficient, and the current pulse frequency; where the first threshold value is the opposite of the second threshold value, and the second threshold value is the product of the first correction coefficient, the second correction coefficient, and the current pulse frequency; If the reference compensation value is less than the first threshold value, use the first threshold value as the pulse frequency compensation value; If the reference compensation value is greater than or equal to the first threshold value and less than or equal to the second threshold value, use the reference compensation value as the pulse frequency compensation value; If the reference compensation value is greater than the second threshold value, use the second threshold value as the pulse frequency compensation value.

3. The device according to claim 1, characterized in that, The determination module is further configured to perform an output limit on the output pulse frequency according to a third preset parameter.

4. The device according to claim 3, characterized in that, The third preset parameter includes a maximum dose rate, a pulse frequency conversion coefficient, a pulse frequency tolerance, and a maximum output pulse frequency. When the determination module is configured to perform an output limit on the output pulse frequency according to the third preset parameter, it is further configured to: If the output pulse frequency is greater than the ratio of the maximum dose rate to the pulse frequency conversion coefficient, use the calculation result obtained according to the maximum dose rate, the pulse frequency conversion coefficient, the pulse frequency tolerance, and the maximum output pulse frequency as the output pulse frequency.

5. A computer device, characterized in that, including: A memory, a processor, and a radiation source device, where the memory is used to store a computer program; The processor is used to execute the following method when calling the computer program: Obtain the current actual dose, the current target dose, and the current pulse frequency, where the current pulse frequency is used to characterize the dose rate of the radiation beam emitted by the radiation source device; Calculate a dose difference according to the current actual dose and the current target dose; If the dose difference is not less than a preset threshold, determine a reference compensation value according to the dose difference, the single-pulse dose, the first period, and the second period; where the first period is the time required for the radiation source device to rotate a preset angle, and the second period is the number of rotations of the radiation source device; Determine a first correction coefficient according to the dose difference and a first preset parameter; where the first correction coefficient is a piecewise function of the dose difference, and the first preset parameter is the piecewise basis of the piecewise function of the dose difference; Determine a second correction coefficient according to the reference compensation value and a second preset parameter; where the second correction coefficient is a piecewise function of the reference compensation value, and the second preset parameter is the piecewise basis of the piecewise function of the reference compensation value; Dynamically adjust the reference compensation value according to the first correction coefficient, the second correction coefficient, and the current pulse frequency to obtain a pulse frequency compensation value; Adjust the current pulse frequency according to the pulse frequency compensation value to obtain an output pulse frequency; Update the dose rate of the radiation beam emitted by the radiation source device according to the output pulse frequency.

6. The device according to claim 5, characterized in that, The dynamically adjusting the reference compensation value according to the first correction coefficient, the second correction coefficient, and the current pulse frequency to obtain a pulse frequency compensation value includes: Determine a first threshold value and a second threshold value according to the first correction coefficient, the second correction coefficient, and the current pulse frequency; where the first threshold value is the opposite of the second threshold value, and the second threshold value is the product of the first correction coefficient, the second correction coefficient, and the current pulse frequency; If the reference compensation value is less than the first threshold value, use the first threshold value as the pulse frequency compensation value; If the reference compensation value is greater than or equal to the first threshold value and less than or equal to the second threshold value, use the reference compensation value as the pulse frequency compensation value; If the reference compensation value is greater than the second threshold value, use the second threshold value as the pulse frequency compensation value.

7. The device according to claim 5, characterized in that,The method further includes: performing an output limit on the output pulse frequency according to a third preset parameter.

8. The device according to claim 7, wherein, The third preset parameter includes a maximum dose rate, a pulse frequency conversion coefficient, a pulse frequency tolerance, and a maximum output pulse frequency. The performing an output limit on the output pulse frequency according to the third preset parameter includes: If the output pulse frequency is greater than the ratio of the maximum dose rate to the pulse frequency conversion coefficient, use the calculation result obtained according to the maximum dose rate, the pulse frequency conversion coefficient, the pulse frequency tolerance, and the maximum output pulse frequency as the output pulse frequency.

9. A computer-readable storage medium having a computer program stored thereon, wherein, The computer program, when executed by the processor, implements the following method: Obtain the current actual dose, the current target dose, and the current pulse frequency, where the current pulse frequency is used to characterize the dose rate of the radiation beam emitted by the radiation source device; Calculate the dose difference according to the current actual dose and the current target dose; If the dose difference is not less than a preset threshold, determine a reference compensation value according to the dose difference, the single-pulse dose, the first period, and the second period; where the first period is the time required for the radiation source device to rotate a preset angle each time, and the second period is the number of rotations of the radiation source device; Determine a first correction coefficient according to the dose difference and a first preset parameter; where the first correction coefficient is a piecewise function of the dose difference, and the first preset parameter is the segmentation basis of the piecewise function of the dose difference; Determine a second correction coefficient according to the reference compensation value and a second preset parameter; where the second correction coefficient is a piecewise function of the reference compensation value, and the second preset parameter is the segmentation basis of the piecewise function of the reference compensation value; Dynamically adjust the reference compensation value according to the first correction coefficient, the second correction coefficient, and the current pulse frequency to obtain a pulse frequency compensation value; Adjust the current pulse frequency according to the pulse frequency compensation value to obtain an output pulse frequency; Update the dose rate of the radiation beam emitted by the radiation source device according to the output pulse frequency.

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