Method, control device and treatment device for providing ophthalmic surgery laser control data of treatment device based on patient-specific parameter set

Abstract

The invention relates to a method for providing control data for an ophthalmic surgical laser (12) of a treatment device (10) for treating a human or animal eye (16), wherein the method is used to optimize the conflict between the objectives of low stress on the patient and the highest possible laser efficacy, the method comprising the following steps performed by a control device (18): determining (S1) a patient-specific parameter set, the patient-specific parameter set being associated with at least one physiological property of the eye (16), determining (S4) at least one physical parameter of the ophthalmic surgical laser (12) based on the patient-specific parameter set, wherein the physical parameter relates to a physical property of a laser beam (19) of the laser (12), and providing (S5) control data for controlling the ophthalmic surgical laser (12), the control data comprising the physical parameter.

Description

Technical Field

[0001] The invention relates to a method for providing control data of an ophthalmic surgical laser of a treatment device for treating a human or animal eye, in particular the cornea of ​​the eye. A second aspect of the invention relates to a control device, which is formed to perform the method. A third aspect of the invention relates to a treatment device having at least one ophthalmic surgical laser and said control device. Further aspects of the invention relate to a computer program and a computer-readable medium. Background Art

[0002] From the prior art are known therapeutic devices and methods for controlling ophthalmic surgical lasers for correcting optical visual disorders and / or pathological and / or unnaturally altered areas of the patient's cornea. In this case, for example, a pulsed laser and a beam arrangement can be formed so that the laser pulses achieve photodisruption and / or photoablation in a focus located within the organic tissue in order to remove tissue, in particular tissue microlenses, from the cornea. In this way, the refractive power of the eye and the cornea, respectively, can be changed, thereby improving the vision of the corresponding patient. In order that the transition from the tissue to be removed to the cornea is not too abrupt, for example too steep, a transition area ("transition zone") is usually provided in the edge area of ​​the tissue to be removed, which provides a flat transition for moving the tissue into the cornea.

[0003] Among other things, today's systems and methods allow, for example, universal treatment methods or methods that are adapted to the respectively treated patient, for example taking into account topographic information of the cornea or of the respective patient or information about imaging errors and information about the wavefront (related to the light incident on the eye of the respective patient). The adaptation mentioned to the respective patient is thus consumed in the respective capture and mapping of the surface of his eye and cornea and in the creation of an ablation map adapted thereto.

[0004] In the treatment or orthokeratology of the cornea, there is always a conflict of objectives between low stress on the patient and the highest possible laser efficacy, for example efficacy of photoablation or photodisruption of the corresponding laser pulses of the laser. This therefore poses an optimization problem. SUMMARY OF THE INVENTION

[0005] The object of the present invention is to achieve an improved solution to the optimization problem for patient treatment and corneal correction, respectively.

[0006] According to the invention, this object is solved by the subject matter of the independent claim. Advantageous embodiments with expedient developments are the subject matter of the dependent claims.

[0007] The invention is based on the idea of ​​adapting and adjusting the physical properties of an ophthalmic surgical laser for treating the cornea of ​​a patient in a patient-specific manner. In this context, for example, patient-specific physical parameters can be determined for the ophthalmic surgical laser. By taking into account the patient-specific physical parameters in the operation of the laser, it is possible to operate at the optimum value of the mentioned optimization problem in an improved manner. Thus, the operation of the laser and its physical properties can be optimized in a patient-specific manner, respectively, solving the conflict of objectives between low stress on the patient and high efficacy of photoablation and photodisruption in an improved manner.

[0008] A first aspect of the invention claims a method for providing control data for an ophthalmic surgical laser of a therapeutic device for treating a human or animal eye, in particular a cornea, wherein the method comprises the following steps performed by a control device.

[0009] - determining a patient-specific set of parameters that are related to at least one physiological property of the eye;

[0010] - determining at least one physical parameter of the ophthalmic surgical laser based on the patient-specific parameter set, wherein the physical parameter is related to a physical property of the laser beam of the laser, and providing control data for controlling the ophthalmic surgical laser, the control data comprising the physical parameter; and

[0011] -Provide control data for controlling an ophthalmic surgical laser, the control data including physical parameters.

[0012] Determining a patient-specific parameter set may comprise determining one or more patient-specific parameters. The one or more patient-specific parameters that together constitute the patient-specific parameter set may each be individually or collectively related to a physiological property of the eye. Exemplary physiological properties of the eye that may be described by the patient-specific parameter set are the reflectivity of the surface of the eye, the moisture content of the eye, the corresponding size and diameter, or the radius of an existing or planned optical zone of the eye, the degree of myopia or hyperopia, the age of the patient, the sensitivity of the eye and the corresponding tissue of the cornea to the laser pulses and / or the like. One or more exemplary physiological properties of the eye may be characterized and quantified, respectively, by means of the patient-specific parameter set. Each physiological property of the eye, such as one of the exemplary mentioned physiological properties and / or different physiological properties, may be characterized and quantified, respectively, by means of one or more patient-specific parameters.

[0013] At least one physical parameter of the ophthalmic surgery laser is determined according to a patient-specific parameter set. The at least one physical parameter can be determined, for example, based on or taking into account one or more patient-specific parameters. Based on the at least one physical parameter, the operation of the ophthalmic surgery laser can be adapted in a patient-specific manner, thus in particular to at least one physiological property of the eye. For example, the operation of the ophthalmic surgery laser can be adapted to one or more physiological properties of the eye listed above by way of example. The physical properties of the laser beam of the laser can be preset by a corresponding specification of the at least one physical parameter. In other words, at least one physical property of the laser beam of the laser depends on the physical parameter. Thus, the physical properties of the laser beam can be adapted to the patient's eye.

[0014] By providing control data including physical parameters, the ophthalmic surgical laser can be controlled or influenced according to the physical parameters. In particular, the physical properties of the laser can be adjusted or preset according to the control data corresponding to at least one physical parameter. For example, the adjustment of the ophthalmic surgical laser can depend on the physical parameters and the control data part of the method respectively. In this case, for example, the adjustment can be performed by the same control device, by which the remaining described method steps are performed. Alternatively, it can be provided that the ophthalmic surgical laser is controlled and adjusted by different control devices respectively. In this case, the provision of the control data can be realized, for example, by corresponding interfaces to the different control devices. The control data including the physical parameters can then be transmitted or transferred to the different control devices via the interface.

[0015] In summary, the invention has the advantage that the laser beam of the laser can be physically adapted to the patient and his eye respectively by determining a patient-specific parameter set and at least one physical parameter. Thus, the patient-specific optimum for the originally described conflicting goals of as low a pressure on the patient as possible and high efficiency of photoablation and photodisruption can be adjusted or preset respectively by the corresponding influencing of the laser beam. Thus, an optimal ratio of high efficiency of the laser beam and low pressure of the laser beam on the patient can be determined and adjusted in a patient-specific manner.

[0016] According to one development, the method comprises the following additional steps:

[0017] - providing a patient-non-specific parameter set, which is based on a plurality of patient cross-sections and comprises at least one standard value for at least one physiological property of the eye; and

[0018] - Determine the deviation between the patient non-specific parameter set and the patient specific parameter set, where

[0019] - At least one physical parameter is determined at least as a function of the previously determined deviation.

[0020] The patient-non-specific parameter set may include as a standard value the average value of at least one physiological characteristic of the eyes of multiple patients. Of course, the patient-non-specific parameter set may include corresponding or multiple corresponding standard values ​​for different or multiple physiological characteristics. Therein, the standard value may present or represent an average value, a median value, a cumulative value or any other value, which describes multiple patients on average. In other words, at least one physiological characteristic of the eyes in cross-sections of multiple patients may be described by a standard value. In the case of multiple standard values ​​as part of the patient-non-specific parameter set, each standard value may respectively relate to and describe the corresponding physiological characteristic of the eyes in cross-sections of multiple patients. Since one or more standard values ​​are related to multiple patients, the designation is as patient-non-specific. In contrast, the patient-specific parameter set is specific to the corresponding patient.

[0021] When determining the deviation between the patient-nonspecific parameter set and the patient-specific parameter set, it can be determined how far the patient-specific parameter deviates from the standard value. In the case of multiple patient-specific parameters, it can be determined how far the patient-specific parameter deviates from the corresponding standard value of the same physiological property of the eye. In this way, the deviation can specify the severity of the overlap of at least one physiological property of the eye with the cross-sections of multiple patients. The physical parameters of the ophthalmic surgical laser are then determined based on the deviation. Therein, the deviation can be represented by a single numerical value or by a matrix or the like. For example, a standard value can be preset or obtained for the physical parameter. Then, the determination of the physical parameter based on the deviation can be achieved, so that at least one physical parameter is derived from the standard value of the corresponding physical parameter based on the deviation between the patient-nonspecific parameter set and the patient-specific parameter set. In this way, the manifestation of the physiological property that is common in many patients and the patient-specific manifestation of the physiological property can be considered simultaneously in a particularly advantageous manner.

[0022] According to a development, it is provided that at least one physical parameter is determined based on an eye model, which eye model is adapted to the patient based on a patient-specific parameter set starting from a basic model. For example, the basic model can take into account at least one patient-specific parameter and / or can be adapted to the patient by an adaptation based on at least one patient-specific parameter. Thus, a patient-specific model is derived from the basic model based on the patient-specific parameter set. Such a model can be simulated and optimized in a specific manner for at least one physical parameter, respectively. Thus, based on such a derived patient-specific model, the optimization of the physical properties of the laser beam can be adapted to the patient to a specific extent.

[0023] According to a refinement, at least one physical parameter is determined using a respectively different model, depending on the type of planned treatment for the eye. In particular, respectively different basic models are provided for different treatments of the eye. Depending on the planned treatment for the eye, a basic model specific to the respective treatment can be selected from a plurality of basic models and adapted to the patient. Different models and different basic models, respectively for different types of treatment, can respectively take into account different influencing factors, different patient-specific parameters and / or physiological properties of the eye. Thus, the model is respectively adapted to the treatment to be performed to a certain extent.

[0024] According to a refinement, the respective values ​​of the prescribed wavelength and / or pulse duration and / or pulse energy are determined as at least one physical parameter. In other words, the physical parameter can be a preset wavelength for the laser beam. Alternatively or additionally, the physical parameter can be a preset pulse duration for the laser beam. Alternatively or additionally, the physical parameter can be a preset pulse energy for the laser beam. In yet another word, at least one physical parameter can be a preset respective value for one or more of the exemplary physical quantities and physical properties of the laser beam. In this way, it is taken into account that the quantities mentioned have a particularly favorable influence on the initially mentioned target conflicts.

[0025] According to one refinement, at least one physical parameter is determined as a function of the angle of incidence of the laser beam on the eye surface. In particular, it can be provided that the greater the pulse energy, the flatter the angle of incidence. Conversely, the smaller the pulse energy, the steeper the angle of incidence. In other words, depending on the angle of incidence, the laser beam can have a minimum value for the perpendicular angle of incidence on the eye or corneal surface.

[0026] In a further configuration, provision can be made for the angle of incidence of the laser beam to be derived based on the size of the optical zone to be generated by the treatment. In this way, it can be taken into account that the angle of incidence becomes increasingly flatter with increasing size of the optical zone. In this way, a correlation between the size of the optical zone and the pulse energy of the laser beam can emerge. Advantageously, the greater the pulse energy, the larger the optical zone.

[0027] In general, according to the correlation between pulse energy and angle of incidence, it can be taken into account that a larger part of the laser pulse is reflected by the eye at a flatter angle of incidence. Therefore, a lower part of the laser pulse or laser beam will be used for a treatment with the same pulse energy and a larger angle of incidence. The part of the laser beam or laser pulse reflected by the eye cannot contribute to the therapeutic success of the treatment. This can be taken into account or compensated by the current automatic increase of the pulse energy, which depends on the angle of incidence and the size of the optical zone, respectively. The pulse energy is in particular the total energy emitted by the laser beam during the laser pulse. Therein, it should be noted that, as has already been described, the laser is operated in a pulsed manner. Therefore, the pulse energy can be the integral of the pulse energy.

[0028] According to a refinement, it is provided that the value of the moisture content of the eye is determined as at least one physiological characteristic of the eye. In particular, it is provided that the higher the pulse energy determined, the greater the moisture content of the eye represented by the value. In other words, the greater the pulse energy, the greater the moisture content of the eye represented by the value. The value of the moisture content of the eye can be a parameter of a patient-specific parameter set. For example, the moisture content of the eye can be measured by a corresponding capture device for measuring the moisture content of the eye. Alternatively or additionally, the moisture content of the eye can be determined or estimated by a corresponding algorithm, for example based on an image of the eye, such as a digital photograph of the eye. Alternatively or additionally, the value of the moisture content of the eye can be derived or determined from a user input, for example, by a corresponding input device connected to the control device. Alternatively or additionally, the moisture content or value can be derived from the patient's age. This is based on such a recognition that the moisture content of the eye generally increases with the patient's age. In a further configuration, the value of the moisture content of the eye can also be a statement about the patient's age. In this case, the moisture content of the eye can be expressed according to the age or age statement. This means in particular that the higher the pulse energy of the selected laser beam, the older the patient. In summary, the value for the moisture content of the eye can be based on measured values, image-assisted estimation by an algorithm, user statements and / or the patient's age. Of course, combinations of the enumerated possibilities for determining the value for the moisture content are also possible. The value for the moisture content of the eye can specify the moisture content or information related to the moisture content of the eye, such as the patient's age. Thus, it can be considered in general that with increasing moisture content of the eye a higher pulse energy is required to ensure a preset ablation efficiency and photodisruption efficiency, respectively.

[0029] According to a further development, the pulse energy is determined as a function of the diopter to be corrected by the treatment. In particular, it can be provided that, in the case of myopia treatment, the smaller the pulse energy determined, the larger the diopter to be corrected. Alternatively or additionally, it can be provided that, in the case of hyperopia treatment, the larger the pulse energy determined, the larger the diopter to be corrected. In other words, the pulse energy can be determined as a function of the visual impairment of the patient to be corrected. However, it is optimally dependent on the type of the respective visual impairment. Thus, depending on the type of the respective visual impairment, for example myopia or hyperopia, the pulse energy can be increased or decreased as the visual impairment or diopter to be corrected increases. In the case of myopia treatment, the smaller the pulse energy selected, the larger the diopter or visual impairment to be corrected. Conversely, in the case of myopia treatment, the larger the pulse energy that can be determined, the lower or smaller the diopter or visual impairment to be corrected. In the case of hyperopia treatment, the correlation between the pulse energy and the diopter to be corrected is preferably the opposite. In the case of hyperopia treatment, the larger the pulse energy that can be determined, the larger the diopter or visual impairment to be corrected. Conversely, in the case of treating presbyopia, the pulse energy can be selected to be smaller, the smaller or lower the diopter or visual impairment to be corrected. In this way, the treatment can be ensured in a patient-specific manner according to the patient's visual impairment while ensuring an optimal effect and low invasiveness.

[0030] According to the improvement, in the case of ablation, the pulse energy is adjusted primarily in a patient-specific manner, and / or in the case of photodisruption, the pulse duration is adjusted primarily in a patient-specific manner. In other words, the dominant variable in the case of ablation for patient-specific adaptation of the laser beam can be the pulse energy. Alternatively or additionally, in the case of photodisruption or bubble formation, the dominant variable for adapting the laser beam to the patient can be the pulse duration. For example, in the case of photoablation or ablation, the pulse energy can have a larger range of variation or value range than in the case of photodisruption or bubble formation. Alternatively or additionally, in the case of photodisruption or bubble formation, the pulse duration can have a larger range of variation or value range than in the case of ablation or photoablation. In this way, depending on the type of treatment to be performed, a corresponding or even better adaptation to the patient can be allowed.

[0031] A second aspect of the present invention relates to a control device, which is configured to perform one of the above methods. The above advantages are generated. For example, the control device can be configured as a control chip, a control device or an application program ("application"). Preferably, the control device may include a processor device and / or a data memory. The processor device understands an apparatus or an apparatus component for electronic data processing. For example, the processor device may include at least one microcontroller and / or at least one microprocessor. Preferably, the program code for performing the method according to the present invention can be stored on an optional data memory. Then, the program code can be configured to cause the control device to perform one of the above embodiments of one or both methods according to the present invention when executed by the processor device.

[0032] A third aspect of the invention relates to a therapeutic device having at least one ophthalmic surgical laser for separating tissue predefined by control data, in particular a corneal volume with a predetermined interface of a human or animal eye, by photodisruption and / or photoablation, and at least one control device for the laser or lasers, which is formed to carry out the steps of the method according to the first aspect of the invention. The therapeutic device according to the invention allows to reliably reduce or even avoid the disadvantages that occur when using conventional ablative therapeutic devices.

[0033] In another advantageous configuration of the treatment device according to the invention, the laser can be suitable for emitting laser pulses in a wavelength range between 300 nm and 1400 nm, preferably between 700 nm and 1200 nm, with a corresponding pulse duration between 1 fs and 1 ns, preferably between 10 fs and 10 ps, ​​with a repetition frequency greater than 10 kilohertz (kHz), preferably between 100 kHz and 100 megahertz (MHz). Such femtosecond lasers are particularly suitable for removing tissue within the cornea. The use of photodisruption and / or photoablation lasers in the method according to the invention also has the advantage that no irradiation of the cornea is necessary in the wavelength range below 300 nm. In laser technology, this range is referred to as "deep ultraviolet". As a result, unintentional damage to the cornea caused by these very short wavelength and high-energy beams is advantageously avoided. Photodisruption lasers of the type used here typically input pulsed laser radiation with a pulse duration between 1 fs and 1 ns into the corneal tissue. As a result, the power density of the individual laser pulses required for optical penetration can be narrowly limited spatially, thereby allowing a high cutting accuracy in the interface generation. In particular, the range between 700 nm and 780 nm may also be selected as the wavelength range.

[0034] In another advantageous embodiment of the treatment device according to the invention, the control device can include at least one storage device for at least temporarily storing at least one control data set, wherein one or more control data sets include control data for positioning and / or focusing individual laser pulses in the cornea and can include at least one beam device for beam guiding and / or beam shaping and / or beam deflection and / or beam focusing of the laser beam of the laser. The control data set includes control data determined in the method for removing tissue.

[0035] Further features and advantages thereof can be derived from the description of the first inventive aspect, wherein advantageous configurations of each inventive aspect should be considered as advantageous configurations of the other inventive aspect, respectively.

[0036] A fourth aspect of the invention relates to a computer program comprising instructions for causing a therapeutic apparatus according to the third inventive aspect to perform the method steps according to the first inventive aspect.

[0037] A fifth aspect of the invention relates to a computer readable medium on which a computer program according to the fourth inventive aspect is stored. Other features and advantages thereof can be derived from the description of the first to fourth inventive aspects, wherein an advantageous construction of each inventive aspect should be considered as an advantageous construction of another inventive aspect, respectively. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Further features are evident from the claims, the drawings and the description of the drawings. The features and feature combinations mentioned above in the description of the drawings and the features and / or feature combinations mentioned below in the description of the drawings and / or the features and feature combinations shown only in the drawings can be used not only in the respectively specified combination but also in other combinations without departing from the scope of the invention. Therefore, embodiments which are not explicitly shown and described in the drawings are also to be considered to be encompassed and disclosed by the present invention, but are produced and generated by feature combinations separate from the described embodiments. Embodiments and feature combinations are also to be considered to be disclosed and therefore do not include all features of the originally formulated independent claims. Furthermore, embodiments and feature combinations which go beyond or deviate from the feature combinations set out in relation to the claims are to be considered to be disclosed, in particular by the embodiments set out above. It is shown:

[0039] Figure 1 is a schematic diagram of a therapeutic apparatus according to the present invention according to an exemplary embodiment; and

[0040] Figure 2 is a flow chart of a method according to the present invention according to an exemplary embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0041] Figure 1 A schematic diagram of a treatment device 10 with an ophthalmic surgical laser 12 for removing tissue 14 of a human or animal eye 16 by photodisruption and / or photoablation is shown. For example, the tissue 14 may represent a lenticule or also a volumetric body, which may be separated from the cornea 16 of the eye to correct a visual disorder by the ophthalmic surgical laser 12. The geometry of the tissue 14 to be removed, and thus the tissue removal geometry 14, may be provided by a control device 18, in particular in the form of control data, so that the laser 12 emits pulsed laser pulses into the cornea 16 of the eye in a pattern predefined by the control data to remove the tissue 14. Alternatively, the control device 18 may be a control device 18 external to the treatment device 10.

[0042] also, Figure 1 It is shown that the laser beam 19 generated by the laser 12 can be deflected by a beam deflection device 22, ie a beam deflection apparatus, such as a rotary scanner, towards the eye 16 to remove tissue 14. The beam deflection apparatus 22 can also be controlled by the control device 18 to remove tissue 14.

[0043] Preferably, the illustrated laser 12 may be a photodestructive and / or photoablative laser, which is formed to emit laser pulses in a wavelength range between 300 nm and 1400 nm, preferably between 700 nm and 1200 nm, with a corresponding pulse duration between 1 femtosecond and 1 nanosecond, preferably between 10 femtoseconds and 10 picoseconds, and a repetition frequency greater than 10 kHz, preferably between 100 kHz and 100 MHz. Optionally, the control device 18 further comprises a storage device (not shown) for at least temporarily storing at least one control data set, wherein one or more control data sets include control data for positioning and / or focusing individual laser pulses in the cornea. The position data and / or focusing data of the individual laser pulses, i.e. the tissue removal geometry 14, are determined based on the method described below.

[0044] Figure 2 A flow chart of an exemplary embodiment of a method for providing control data for an ophthalmic surgery laser 12 of a treatment device 10 is shown. Therein, the control data for the ophthalmic surgery laser 12 of the treatment device 10 is determined for performing corneal correction according to externally determined correction values. Thus, corneal correction can be performed according to the control data. In other words, the ophthalmic surgery laser 12 and the treatment device 10 perform the corresponding corneal correction determined according to the correction value in the control according to the control data generated by the method.

[0045] The method exemplarily includes the following steps performed by the control device 18:

[0046] Step S1: determining a patient-specific parameter set related to at least one physiological property of the eye 16,

[0047] Step S2: providing S2 a patient non-specific parameter set based on a plurality of patient cross-sections and comprising at least one standard value of at least one physiological property of the eye 16, and

[0048] - step S3: determining the deviation between the patient non-specific parameter set and the patient specific parameter set,

[0049] - step S4: determining at least one physical parameter of the ophthalmic surgery laser 12 according to the patient-specific parameter set, wherein the physical parameter relates to a physical property of the laser beam 19 of the laser 12, wherein the determination of the at least one physical parameter is carried out at least in dependence on a deviation, and

[0050] - Step S5: Providing control data for controlling the ophthalmic surgical laser 12, the control data comprising physical parameters.

[0051] Determining the patient-specific parameter set may comprise determining one or more patient-specific parameters. The one or more patient-specific parameters are currently determined by a determination device 20. The determination device 20 may be part of the treatment device 10 and / or part of the control device 18. The one or more patient-specific parameters each individually or collectively relate to one or more physiological properties of the eye 16. Exemplary physiological properties of the eye 16 that may be described by the patient-specific parameter set are the reflectivity of the surface of the eye, the moisture content of the eye 16, the corresponding size and diameter, or the radius of an existing or planned optical zone of the eye, the degree of myopia or hyperopia, the age of the patient, the sensitivity of the tissue of the eye or cornea with respect to laser pulses and / or the like.

[0052] For example, the determination device 20 may include a measuring unit for measuring or estimating the moisture content of the eye 16. Alternatively, the moisture content of the eye 16 may be derived or estimated at least from the age of the patient. This may be achieved based on a predetermined formula. For example, the age of the patient may be derived from a user input from a user, in particular a doctor. The user input may be received by the determination device 20, for example from a patient database or an input device. Calculations based on this may be performed, for example, by a microprocessor, a digital signal processor (DSP), an FPGA, etc. of the determination device 20 and / or the control unit 18.

[0053] The size and / or diameter and / or radius of the planned optical zone of the eye 16 can be derived, for example, from the ablation data and / or the photodisruption data. Based on the ablation data and / or the photodisruption data, the diopter to be corrected by the treatment can be determined in addition. Similarly, it can be determined whether the visual impairment to be corrected is myopia or hyperopia. The ablation data and the photodisruption data describe and quantify the currently planned ablation and photodisruption, respectively, for correcting the refractive or visual impairment (thus, for example, myopia or hyperopia). The ablation data can be, for example, an ablation map. In the present embodiment, it is provided that at least one physical parameter is determined according to the angle of incidence of the laser beam 19 on the surface of the eye 16. The angle of incidence of the laser beam 19 can be derived from the size and / or diameter and / or radius of the planned optical zone of the eye 16. Among them, a flatter angle of incidence usually comes from a larger optical zone. The calculations based on this can be performed, for example, by a microprocessor, a digital signal processor (DSP), an FPGA, etc. of the determination device 20 and / or the control unit 18.

[0054] The patient-non-specific parameter set may include an average value of at least one physiological characteristic of the eyes of multiple patients as a standard value. For example, the patient-non-specific parameter set may be retrieved from the model database 22. Of course, the patient-non-specific parameter set may include corresponding or multiple corresponding standard values ​​for different or multiple physiological characteristics. Therein, the standard value may present or represent an average value, a median value, a cumulative value or any other value that describes multiple patients on average. In other words, at least one physiological characteristic of the eyes in cross-sections of multiple patients may be described by a standard value. In the case of multiple standard values ​​that are part of the patient-non-specific parameter set, each standard value may relate to or describe a corresponding physiological characteristic of the eyes in cross-sections of multiple patients. Since one or more standard values ​​are related to multiple patients, the designation is implemented as patient-non-specific. In contrast, a patient-specific parameter set is specific to the corresponding patient.

[0055] When determining the deviation between the patient-non-specific parameter set and the patient-specific parameter set, it can be determined how far the patient-specific parameter deviates from the corresponding standard value of the same physiological property of the eye. In this way, the deviation can specify the severity of the overlap of at least one physiological property of the eye with cross-sections of multiple patients. The deviation can be represented by a single numerical value, a matrix, etc.

[0056] The model database 22 may contain one or more biophysical models of the eye. Based on a patient-specific parameter set, the corresponding model may be adapted to the individual patient. In other words, the corresponding model may be parameterized based on the parameters of the patient-specific parameter set. Thus, on the one hand, a deviation between a standard basic model and a patient-specific parameterized model may be determined. This deviation may be used to determine a patient-specific adaptation starting from the standard basic model, instead of or in addition to the deviation between the above-mentioned patient-non-specific parameter set and the patient-specific parameter set. For example, the standard basic model may be parameterized by a patient-non-specific parameter set. Alternatively or additionally, the patient-specific parameterized model may be used to simulate the influence of the physical parameters and the influence of the patient-specific adaptation of the physical parameters, respectively.

[0057] Therein, it is particularly provided that, depending on the type of planned treatment for the eye 16, respectively different models are applied or used. In particular, respectively different basic models are provided for different treatments on the eye 16. Depending on the planned treatment for the eye, a basic model specific to the respective treatment can be selected from a plurality of basic models and adapted to the patient corresponding to the above-mentioned parameterization. Different models or different basic models for different types of treatment can respectively take into account different influencing factors, different patient-specific parameters and / or physiological properties of the eye. Thus, the model is respectively adapted to the treatment to be performed to a certain extent.

[0058] For example, the physical parameter can be determined starting from a standard value. For example, a standard value can be preset or obtained for the physical parameter. A patient-specific determination of the physical parameter depending on the deviation can then be achieved, so that at least one physical parameter is derived from the standard value of the corresponding physical parameter depending on the deviation between the patient-inspecific parameter set and the patient-specific parameter set and / or the deviation between the standard model and the patient-specific parameterized model.

[0059] Currently, wavelength as well as pulse duration and pulse energy are determined as corresponding physical parameters. In other words, the physical parameters can preset the wavelength of the laser beam 19. Alternatively or additionally, the physical parameters can preset the pulse duration of the laser beam 19. Alternatively or additionally, the physical parameters can preset the pulse energy of the laser beam 19.

[0060] At present, the determination of the physical parameters, in particular the determination of the pulse energy, depends on the angle of incidence of the laser beam 19 on the surface of the eye 16. In this context, it can be provided in particular that the greater the pulse energy, the flatter the angle of incidence. Conversely, the smaller the pulse energy, the steeper the angle of incidence. As described above, the angle of incidence of the laser beam 19 is derived on the basis of the size of the optical zone to be produced by the treatment. In this way, it can be taken into account that the angle of incidence becomes increasingly flatter with increasing size of the optical zone. In this way, a correlation between the size of the optical zone and the pulse energy of the laser beam emerges. In this context, advantageously, the greater the pulse energy, the larger the optical zone.

[0061] Currently, the determination of the physical parameters, in particular the determination of the pulse energy, depends on the moisture content of the eye 16. In particular, it is provided that the higher the determined pulse energy, the greater the moisture content of the eye. Alternatively or additionally, the moisture content or value can be derived from the patient's age. This is based on the recognition that the moisture content of the eye generally increases with the patient's age. The moisture content of the eye can be derived from the age or can also be expressed as an age statement. This means in particular that the pulse energy of the selected laser beam is higher the older the patient is.

[0062] At present, the determination of the physical parameters, in particular the determination of the pulse energy, depends on the diopter to be corrected by the treatment. In particular, it can be provided that in the case of myopia treatment, the smaller the determined pulse energy, the greater the diopter to be corrected. Alternatively or additionally, it can be provided that in the case of hyperopia treatment, the greater the determined pulse energy, the greater the diopter to be corrected.

[0063] Overall, the embodiments show how the treatment can be highly adapted to the patient in an automated manner. Thus, a particularly high treatment efficiency can be particularly well coupled with the lowest possible patient stress.

[0064] List of reference numerals:

[0065] 10 Treatment Equipment

[0066] 12 Laser

[0067] 14 Organization

[0068] 16 Eyes

[0069] 17 Beam deflection device

[0070] 18 Control Devices

[0071] 19 Laser Beam

[0072] 20 Determine the device

[0073] 22 Model Database

[0074] S1…S5 method steps

Claims

1. A method for providing control data for an ophthalmic surgical laser (12) of a therapeutic device (10) for treating a human or animal eye (16) by photoablation and / or photodisruption, wherein the method comprises the following steps performed by a control device (18): - determining (S1) a patient-specific parameter set, said patient-specific parameter set being related to at least one physiological property of said human or animal eye (16), - determining (S4) at least one physical parameter of the ophthalmic surgical laser (12) based on the patient-specific parameter set, wherein the at least one physical parameter relates to a physical property of a laser beam (19) of the ophthalmic surgical laser (12), and - providing (S5) control data for controlling the ophthalmic surgical laser (12), the control data comprising the at least one physical parameter; wherein a corresponding value of the pulse energy is determined as the at least one physical parameter; and The pulse energy is determined as a function of the diopter to be corrected by the treatment, wherein In the case of myopia treatment, as the diopter to be corrected increases, the pulse energy is determined to be smaller, and In the case of hyperopia treatment, as the diopter to be corrected increases, the pulse energy is determined to be larger.

2. The method according to claim 1, Further comprising the steps of: - providing (S2) a patient-non-specific parameter set, said patient-non-specific parameter set being based on a plurality of patient cross-sections and comprising at least one standard value of at least one physiological property of said human or animal eye (16), and - determining (S3) a deviation between the patient-non-specific parameter set and the patient-specific parameter set, wherein - At least depending on the deviation it is determined (S4) that the at least one physical parameter is affected.

3. The method according to claim 1 or 2, Features Determining (S4) the at least one physical parameter is influenced by a model based on the eye, the model being adapted to the patient based on a patient-specific set of parameters starting from a basic model.

4. The method according to claim 3, Features Depending on the type of planned treatment of the human or animal eye, the at least one physical parameter is determined (S4) using a respectively different model.

5. The method according to claim 1, Features The at least one physical parameter is determined (S4) as a function of the angle of incidence of the laser beam on the surface of the human or animal eye, wherein the pulse energy increases as the angle of incidence becomes flatter.

6. The method according to claim 1, Features A value for the moisture content of the human or animal eye is determined as the at least one physiological property of the human or animal eye (16), wherein the higher the determined pulse energy, the greater the moisture content of the human or animal eye (16) represented by the value.

7. The method according to claim 1, Features In the case of ablation, the pulse energy is adapted patient-specifically and / or in the case of photodisruption, the pulse duration is adapted patient-specifically.

8. A control device (18) designed to carry out the method according to claim 1.

9. Treatment device (10) having at least one ophthalmic surgical laser (12) for orthokeratology of the cornea by means of a control device (18) according to claim 8.

10. The therapeutic device (10) according to claim 9, Features The ophthalmic surgical laser (12) is configured to emit laser pulses in a wavelength range between 300 nm and 1400 nm with a respective pulse duration between 1 fs and 1 ns at a repetition rate greater than 10 kHz.

11. The therapeutic device (10) according to claim 9, It is characterized in that Control Devices (18) - comprising at least one storage device for at least temporarily storing at least one control data set, wherein the at least one control data set comprises control data for positioning and / or focusing a single laser pulse in the cornea; and - comprises at least one beam device (17) for beam guiding and / or beam shaping and / or beam deflecting and / or beam focusing the laser beam (19) of the ophthalmic surgery laser.

12. Computer program product comprising instructions for causing a therapeutic device (10) according to any one of claims 9 to 11 to perform a method according to any one of claims 1 to 7.

13. Computer readable medium having stored thereon a computer program product according to claim 12.

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