Adjustable intraocular lens and method for adjusting intraocular lens after surgery

Abstract

An adjustable intraocular lens and a method for postoperatively adjusting an intraocular lens are disclosed. In one embodiment, the adjustable intraocular lens may include an optic portion and a peripheral portion. The peripheral portion may include a composite material including an energy-absorbing component and a plurality of expandable components. The base power of the optic portion may be configured to change in response to external energy directed toward the composite material.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the benefit of U.S. Provisional Application No. 62 / 911,039, filed October 4, 2019, which is incorporated herein by reference in its entirety. Technical Field

[0003] The present disclosure relates generally to the field of intraocular lenses, and more particularly to adjustable intraocular lenses and methods of post-operatively adjusting intraocular lenses. Background Art

[0004] A cataract is a condition involving the clouding of the normally clear lens of a patient's eye. Cataracts can develop as a result of aging, genetic factors, trauma, inflammation, metabolic disorders, or exposure to radiation. Age-related cataracts are the most common type of cataract. To treat cataracts, surgeons remove the lens matrix from the patient's lens capsule and replace it with an intraocular lens (IOL).

[0005] However, current IOL surgeries can leave some patients dissatisfied with their refractive results. In some cases, preoperative biometric measurements of a patient's eye may be incorrect, leading to the prescription and implantation of an IOL with the wrong lens power. In other cases, once the IOL is implanted in the capsular bag, the active healing response of the tissue within the bag can affect the IOL's optical power. Furthermore, a patient's cornea or intraocular muscles may change due to injury, disease, or aging. In these cases, the patient's implanted IOL may also need to be adjusted to account for these changes.

[0006] Therefore, a solution is needed that allows the IOL to be adjusted after implantation to address the above-mentioned issues without the need for additional surgery. Such a solution should not be overly complex and still allow the IOL to be manufactured cost-effectively. Summary of the Invention

[0007] Disclosed herein are accommodating intraocular lenses and methods for postoperatively accommodating intraocular lenses. Such accommodating intraocular lenses may also be referred to as accommodating static focus intraocular lenses or non-accommodating fluid accommodating intraocular lenses.

[0008] In one embodiment, an intraocular lens is disclosed that includes an optic and a peripheral portion coupled to the optic. The peripheral portion may include a composite material comprising an energy absorbing component and a plurality of expandable components. The base power of the optic may be configured to change in response to external energy directed toward the composite material. The base power of the optic may be configured to be unresponsive to forces applied to the peripheral portion by the capsular bag when the intraocular lens is implanted within the capsular bag.

[0009] In some embodiments, the expandable component can be an expandable microsphere. Each of the expandable microspheres can include a blowing agent contained within a thermoplastic shell. The thickness of the thermoplastic shell can be configured to change in response to external energy directed toward the composite material.

[0010] In certain embodiments, the blowing agent can be a branched hydrocarbon. For example, the branched hydrocarbon can be isopentane. Additionally, for example, the thermoplastic shell can be made in part from an acrylonitrile copolymer.

[0011] In some embodiments, the diameter of at least one of the expandable microspheres can be configured to increase by about 2X to about 4X in response to external energy directed to the composite material. The volume of at least one of the expandable components can be configured to expand by about 10X to 50X in response to external energy directed to the composite material.

[0012] In some embodiments, the expandable component may comprise from about 5% to about 15% by weight of the composite material. For example, the expandable component may comprise about 10% by weight of the composite material.

[0013] In some embodiments, the energy absorbing component can be an energy absorbing colorant. The color of the energy absorbing colorant can be visually perceptible when the intraocular lens is implanted in the eye.

[0014] In some embodiments, the energy absorbing colorant can be a dye. For example, the dye can be an azo dye. As a more specific example, the dye can be a disperse red 1 dye.

[0015] In some embodiments, the energy absorbing colorant can be an energy absorbing pigment. For example, the energy absorbing pigment can be graphitized carbon black. In certain embodiments, the energy absorbing component can comprise from about 0.025% to about 1.00% by weight of the composite material.

[0016] In some embodiments, the peripheral portion can be made in part from a cross-linked copolymer comprising a copolymer blend. In these embodiments, the composite material can also be made in part from a copolymer blend.

[0017] The composite material may solidify into a cross-linked copolymer at a location within the peripheral portion, and the composite material may remain substantially fixed at that location.

[0018] The base power of the optical portion can be configured to vary between about ±0.05 D and about ±0.5 D in response to a pulse of external energy directed to the composite material. For example, the base power of the optical portion can be configured to vary by about 0.1 D in response to a pulse of external energy directed to the composite material.

[0019] The base power of the optical portion may be configured to vary in total between about ±1.0 D and about ±2.0 D. The variation in base power may be a continuous variation.

[0020] In some embodiments, the external energy may be light energy. In these embodiments, the light energy may be laser light. The laser light may have a wavelength between approximately 488 nm and approximately 650 nm. For example, the laser light may be a green laser light. The green laser light may have a wavelength of approximately 532 nm.

[0021] In other embodiments, the laser light may have a wavelength between about 946 nm and about 1120 nm. For example, the laser light may have a wavelength of about 1030 nm. Furthermore, for example, the laser light may have a wavelength of about 1064 nm.

[0022] In some embodiments, the laser light may be emitted by a neodymium-doped yttrium aluminum garnet (Nd:YAG) laser. In other embodiments, the laser light may be emitted by a femtosecond laser.

[0023] The energy absorbing component may be configured to transfer thermal energy to the plurality of expandable components in response to external energy directed toward the composite material.

[0024] In some embodiments, the composite material can be formed into discrete peripheral components such that directing external energy to one discrete peripheral component causes a change in the base power of the optical portion, and directing external energy to another discrete peripheral component also causes a change in the base power of the optical portion. In some embodiments, the peripheral portion can include 20 to 40 peripheral components.

[0025] The optical portion of the IOL may include an optical fluid chamber, and the peripheral portion may include at least one peripheral fluid chamber in fluid communication with the optical fluid chamber. In some embodiments, the peripheral fluid chamber is curved and follows the curvature of the optical portion.

[0026] The peripheral fluid chamber may have a chamber height. The chamber height may be between about 0.1 mm and about 0.3 mm.

[0027] In some embodiments, the composite material can be configured as a chamber expander. The chamber expander can be configured to expand in response to external energy directed to the chamber expander. Expansion of the chamber expander can increase the volume of the peripheral fluid chamber. The base focal length of the optical portion can be configured to decrease in response to external energy directed to the chamber expander. The chamber expander can be configured as an expandable column extending from a front wall of the chamber to a rear wall of the chamber.

[0028] In some embodiments, the composite material can be configured as a space filler or piston. The space filler or piston can be configured to expand in response to external energy directed to the space filler or piston. The expansion of the space filler or piston reduces the volume of the peripheral fluid chamber. The space filler or piston can be configured as a pad extending from the front wall or rear wall of the chamber. The base focal length of the optical portion can be configured to increase in response to external energy directed to the space filler or piston.

[0029] The base power may be configured to change in response to fluid displacement between the optical fluid chamber and the peripheral fluid chamber due to external energy directed toward the composite material.

[0030] In some embodiments, the peripheral portion may include a first composite material and a second composite material. In these embodiments, the first composite material may include a first energy absorbing component, and the second composite material may include a second energy absorbing component. The color of the first energy absorbing component may be different from the color of the second energy absorbing component.

[0031] In some embodiments, the peripheral portion can be configured as at least one haptic, and the peripheral fluid chamber can be defined within the haptic. In these embodiments, the peripheral fluid chamber can only partially extend into the haptic.

[0032] The haptic body can include a haptic proximal portion and a haptic distal portion. The haptic distal portion can include a haptic distal arm that is not attached to the optic except via the haptic proximal portion.

[0033] In some embodiments, the haptic distal arm can include a kink or bend.

[0034] The peripheral fluid chamber can be defined within the proximal haptic portion, and a chamber segment of the proximal haptic portion can be unconnected to or separated from the optical portion by a gap or space. The haptic body can be connected to the optical portion at a proximal end of the haptic body and a distal connection portion located distal to the chamber segment.

[0035] In some embodiments, the proximal end of the haptic can be connected to and extend from a side surface of the optical portion. In these embodiments, the side surface can have a side height of approximately 0.65 mm.

[0036] The peripheral portion may be configured as a first haptic including a first tactile fluid chamber and a second haptic including a second tactile fluid chamber.The optical portion may include an optical fluid chamber.

[0037] The first tactile fluid chamber may be in fluid communication with the optical fluid chamber via a first fluid channel. The second tactile fluid chamber may be in fluid communication with the optical fluid chamber via a second fluid channel. The first fluid channel may be positioned diametrically opposite the second fluid channel.

[0038] In some embodiments, the optical fluid chamber, the first tactile fluid chamber, and the second tactile fluid chamber can include a total fluid volume of between about 10 μL and about 20 μL. Each of the first tactile fluid chamber and the second tactile fluid chamber can include about 0.5 μL of fluid. In certain embodiments, in response to a pulse of external energy directed at the composite material, about 15 nL of fluid can be exchanged between the first tactile fluid chamber and the second tactile fluid chamber and the optical fluid chamber. In some embodiments, the fluid can be silicone oil.

[0039] In another embodiment, an intraocular lens is disclosed that includes an optical portion and a peripheral portion coupled to the optical portion. The peripheral portion may include a first peripheral component and a second peripheral component. The first peripheral component may be made of a composite material that includes an energy-absorbing component and a plurality of expandable components. The second peripheral component may also be made of a composite material that includes an energy-absorbing component and a plurality of expandable components. The base focal length of the optical portion may be configured to increase in response to external energy directed to the first peripheral component, and the base focal length of the optical portion may be configured to decrease in response to external energy directed to the second peripheral component. However, the base focal length of the optical portion may be configured to be unresponsive to forces applied to the peripheral portion by the capsular bag when the intraocular lens is implanted within the capsular bag.

[0040] In some embodiments, the optical portion may include an optical fluid chamber, and the peripheral portion may include at least one peripheral fluid chamber in fluid communication with the optical fluid chamber. The base power may be configured to change in response to fluid displacement between the optical fluid chamber and the peripheral fluid chamber due to external energy directed toward the first peripheral portion or the second peripheral portion.

[0041] In some embodiments, the first peripheral component can be configured as a space filler. The space filler can be configured to expand in response to external energy directed toward the space filler. The expansion of the space filler can reduce the volume of the peripheral fluid chamber. For example, the space filler can be configured as an expandable pad extending from the front wall or the rear wall of the chamber.

[0042] In some embodiments, the second peripheral component can be configured as a chamber expander or jack. The chamber expander or jack can be configured to expand in response to external energy directed toward the chamber expander or jack. Expansion of the chamber expander or jack can increase the volume of the peripheral fluid chamber. For example, the chamber expander or jack can be configured as an expandable column extending from the front wall of the chamber to the rear wall of the chamber.

[0043] In some embodiments, the first peripheral component and the second peripheral component can be located within the same peripheral fluid chamber. In these embodiments, the second peripheral component can be positioned distal to the first peripheral component within the same peripheral fluid chamber. Additionally, in these embodiments, the first peripheral component can be positioned proximal to the second peripheral component within the same peripheral fluid chamber. The first peripheral component can be positioned closer to the fluid channel connecting the optical fluid chamber to the peripheral fluid chamber than the second peripheral component.

[0044] The first and second peripheral components can be configured as discrete peripheral components such that directing external energy to one discrete peripheral component can cause a change in the base power of the optical portion, and directing external energy to the other discrete peripheral component can also cause a change in the base power of the optical portion.

[0045] In some embodiments, one peripheral fluid chamber can include at least ten first peripheral components. In these and other embodiments, the same or another peripheral fluid chamber can include at least ten second peripheral components.

[0046] A method for postoperative adjustment of an intraocular lens is also disclosed. The method may include adjusting the base power of the intraocular lens by directing external energy to a composite material within a peripheral portion of the intraocular lens. The peripheral portion may be coupled to an optic portion disposed radially inward of the peripheral portion. The composite material may include an energy-absorbing component and a plurality of expandable components. The base power of the intraocular lens may be configured to be unresponsive to forces applied to the peripheral portion by the capsular bag when the intraocular lens is implanted within the capsular bag.

[0047] The optical portion may include an optical fluid chamber, and the peripheral portion may include at least one peripheral fluid chamber in fluid communication with the optical fluid chamber. The base power of the intraocular lens may change in response to fluid displacement between the optical fluid chamber and the peripheral fluid chamber due to external energy directed toward the composite material. In some embodiments, approximately 15 nL of fluid may be exchanged between the peripheral fluid chamber and the optical fluid chamber in response to a pulse of external energy directed toward the composite material.

[0048] In some embodiments, adjusting the base power of the intraocular lens can further include increasing the base power by directing external energy into a composite material configured as a space filler positioned within a peripheral fluid chamber defined within the peripheral portion.

[0049] The method can also include reducing the base power by directing external energy to another instance of the composite material, the other instance of the composite material being configured as a chamber expander positioned within the peripheral portion.

[0050] In some embodiments, adjusting the base power of the intraocular lens can further include reducing the base power by directing external energy toward a composite material configured as a chamber expander positioned within a peripheral fluid chamber defined within the peripheral portion. Reducing the base power can further include directing external energy toward another instance of the composite material configured as a space filler positioned within the peripheral fluid chamber.

[0051] In some embodiments, adjusting the base power of the intraocular lens can further include directing a pulse of external energy at a first peripheral component within a peripheral fluid chamber defined within the peripheral portion and directing an additional pulse of external energy at a second peripheral component within the same peripheral fluid chamber. The first peripheral component can be made of a composite material, and the second peripheral component can be made of the same composite material.

[0052] In additional embodiments, adjusting the base power of the intraocular lens can further include directing a pulse of external energy at a first peripheral component within a first peripheral fluid chamber defined within the peripheral portion, and directing an additional pulse of external energy at a second peripheral component within a second peripheral fluid chamber defined within the peripheral portion. The first peripheral component can be made of a composite material, and the second peripheral component can be made of the same composite material. The first peripheral fluid chamber can be in fluid communication with the second peripheral fluid chamber via an optical fluid chamber defined within the optical portion.

[0053] In some embodiments, adjusting the base power in a first direction may further include directing external energy to a first composite material and adjusting the base power in a second direction by directing external energy to a second composite material. The first composite material may include a first energy-absorbing component having a first color. The second composite material may include a second energy-absorbing component having a second color different from the first color. BRIEF DESCRIPTION OF THE DRAWINGS

[0054] Figure 1A Illustrated is a top plan view of an embodiment of an accommodating intraocular lens (IOL) with a portion of the front of the accommodating IOL removed to better illustrate components within the IOL.

[0055] Figure 1B An accommodating IOL is shown implanted within the capsular bag of a subject.

[0056] Figure 2A A perspective view of an accommodating IOL is shown.

[0057] Figure 2B A perspective view of an accommodating IOL is depicted with a portion of the front of the accommodating IOL removed to better illustrate components within the IOL.

[0058] Figure 3A The diagram shows the Figure 2A Cross-sectional view of the accommodating IOL taken through the AA cross section.

[0059] Figure 3B The diagram shows the Figure 2A Cross-sectional view of the accommodating IOL taken through the BB cross section.

[0060] Figure 3C External energy directed to a first peripheral component of an accommodating IOL is illustrated.

[0061] Figure 3D External energy directed to a second peripheral component of an accommodating IOL is illustrated.

[0062] Figure 4A A composite material for making at least a portion of an accommodating intraocular lens is illustrated.

[0063] Figure 4B One embodiment of an expandable component of an adjustable intraocular lens is illustrated.

[0064] Figure 5 A top plan view of another embodiment of an accommodating IOL is illustrated with a portion of the front of the accommodating IOL removed to better illustrate components within the IOL.

[0065] Figure 6 A top plan view of an accommodating IOL having a beam-splitting lens surface profile is illustrated.

[0066] Figure 7 is one embodiment of a method for postoperative adjustment of an IOL.

[0067] Figure 8 is another embodiment of a method for postoperative adjustment of an IOL.

[0068] Figure 9 This is yet another embodiment of a method for postoperative adjustment of an IOL.

[0069] Figure 10

[0014] This is yet another embodiment of a method for postoperatively adjusting an IOL. DETAILED DESCRIPTION

[0070] Figure 1A A top plan view of an embodiment of an accommodative static focus intraocular lens (IOL) 100 is illustrated with a portion of the front of the accommodative IOL 100 removed to better illustrate the components within the IOL. Figure 1A As shown in FIG, accommodating IOL 100 may include an optical portion 102 and a peripheral portion 103. Peripheral portion 103 may include one or more haptics 104 including a first haptic 104A and a second haptic 104B extending from or coupled to the periphery of optical portion 102.

[0071] For example, the accommodating IOL 100 can be a one-piece lens (see, e.g., Figures 1A-3B ), such that peripheral portion 103 is connected to and extends from optical portion 102. In this example embodiment, peripheral portion 103 is formed with optical portion 102 and is not adhered or otherwise coupled to optical portion 102 in a subsequent step.

[0072] In other embodiments, the peripheral portion 103 is coupled to and adhered to the optical portion 102. For example, the peripheral portion 103 can be adhered to the optical portion 102 after each is separately formed.

[0073] The optical portion 102 may include an optical fluid chamber 106 (see also, e.g., Figure 2B 、 Figure 3A and Figure 3B ) and one or more peripheral fluid chambers 108 in fluid communication with the optical fluid chamber 106. The one or more peripheral fluid chambers 108 can be defined within the peripheral portion 103. For example, at least one peripheral fluid chamber 108 can extend into the peripheral portion 103.

[0074] In some embodiments, the at least one peripheral fluid chamber 108 can extend only partially into the peripheral portion 103. For example, the at least one peripheral fluid chamber 108 can extend only partially into one-third, one-half, or three-quarters of the peripheral portion 103. Furthermore, for example, the at least one peripheral fluid chamber 108 can extend only partially between one-third and one-half of the peripheral portion 103 or between one-half and three-quarters of the peripheral portion 103.

[0075] In some embodiments, at least one peripheral fluid chamber 108 can extend only partially into one of the haptics 104 of the peripheral portion 103. For example, at least one peripheral fluid chamber 108 can extend only partially into one-third, one-half, or three-quarters of the haptic body 104. Furthermore, for example, at least one peripheral fluid chamber 108 can extend only partially between one-third and one-half of the haptic body 104 or between one-half and three-quarters of the haptic body 104.

[0076] like Figure 1A As shown in FIG, peripheral portion 103 may include two haptics 104 (e.g., first haptic 104A and second haptic 104B). In this embodiment, peripheral fluid chamber 108 may extend into each of the two haptics 104. Peripheral fluid chamber 108 may only partially extend into haptics 104.

[0077] The one or more peripheral fluid chambers 108 may also be referred to as one or more tactile fluid chambers. When the peripheral portion 103 includes the first haptic body 104A and the second haptic body 104B, the peripheral portion 103 may include one peripheral fluid chamber 108 referred to as a first tactile fluid chamber and another peripheral fluid chamber 108 referred to as a second tactile fluid chamber.

[0078] At least one of the haptics 104 (e.g., first haptic 104A, second haptic 104B, or a combination thereof) can be curved. In these embodiments, the peripheral fluid chamber 108 (e.g., the haptic fluid chamber) can be curved. The peripheral fluid chamber 108 can follow the curvature of the haptic 104. When at least a section of the haptic 104 follows the curvature of at least a portion of the optical portion 102, the peripheral fluid chamber 108 can also follow the curvature of the optical portion 102.

[0079] The peripheral fluid chamber 108 can be in fluid communication with the optical fluid chamber 106 or fluidically coupled to the optical fluid chamber 106 via a fluid channel 110. The fluid channel 110 can be a channel or conduit connecting the peripheral fluid chamber 108 to the optical fluid chamber 106. The fluid channel 110 can be along the rear element 300 of the optical portion 102 (see, e.g., Figure 3A and 3B )limited.

[0080] The fluid channel 110 may also be referred to as a channel along the side 111 or side surface of the optical portion 102 (see also, e.g., Figure 2A 、 Figure 2B 、 Figure 3A and Figure 3B ) defined gaps or openings. The fluid channel 110 may be curved. The fluid channel 110 may be substantially shaped as an annular segment.

[0081] The peripheral fluid chamber 108 can be fluidly coupled to or in fluid communication with the optical fluid chamber 106 via a single fluid channel 110. When the accommodating IOL 100 includes multiple peripheral fluid chambers 108, each peripheral fluid chamber 108 can be fluidly coupled to or in fluid communication with the optical fluid chamber 106 via a single fluid channel 110.

[0082] In other embodiments, the peripheral fluid chamber 108 can be fluidically coupled to or in fluid communication with the optical fluid chamber 106 via multiple (e.g., two or more) fluid channels. In these embodiments, the two or more fluid channels 110 can be separated by a channel divider or dividing wall.

[0083] When the peripheral portion 103 includes a first haptic body 104A having a first haptic fluid chamber and a second haptic body 104B having a second haptic fluid chamber, the first haptic fluid chamber can be fluidically connected or fluidically coupled to the optical fluid chamber 106 via a first fluid channel and the second haptic fluid chamber can be fluidically connected or fluidically coupled to the optical fluid chamber 106 via a second fluid channel. In these embodiments, the first fluid channel can be positioned radially opposite the second fluid channel (see, e.g., FIG. 1 ). Figure 1A 、 Figure 1B 、 Figure 2B and Figure 3A ).

[0084] Figure 1A It is illustrated that when peripheral portion 103 is implemented as one or more haptics 104, each haptic body 104 can have a haptic proximal portion 112 and a haptic distal portion 114. A peripheral fluid chamber 108 or haptic fluid chamber can be defined within the haptic proximal portion 112.

[0085] At least a section of the haptic proximal portion 112 can be curved.At least a section of the haptic proximal portion 112 can follow the curvature of at least a portion of the optic portion 102.

[0086] The haptic distal portion 114 can include a haptic distal arm 116. The haptic distal arm 116 can not be attached to the optic portion 102 except via the haptic proximal portion 112.

[0087] The haptic distal arm 116 can include a kink or bend 118 defined along the haptic distal arm 116. The kink or bend 118 can allow the haptic distal arm 116 to compress or flex in response to capsular bag remodeling. The haptic distal arm 116 can terminate in a free or unconnected haptic distal end 120.

[0088] When the peripheral portion 103 includes two haptics 104 (e.g., a first haptic 104A and a second haptic 104B), the accommodating IOL 100 can have an uncompressed haptic length 122 as measured from the haptic distal end 120 of the first haptic 104A to the haptic distal end 120 of the second haptic 104B. The uncompressed haptic length 122 can be between about 12.0 mm and about 14.0 mm. For example, the uncompressed haptic length 122 can be about 13.0 mm.

[0089] The haptic distal end 120 of each haptic 104 can be a closed end of the haptic 104 that is not connected to the optic portion 102. The haptic distal end 120 can include a bulbous feature or a nodule at the end of the haptic distal end 120.

[0090] like Figure 1A As shown in , the optical portion 102 can have an optical portion diameter 124. The optical portion diameter 124 can be between about 5.0 mm and 8.0 mm. For example, the optical portion diameter 124 can be about 6.0 mm.

[0091] The haptics 104 can be connected to the optical portion 102 at a proximal end 126 of the haptics 104. The haptics 104 can also be connected to the optical portion 102 at a distal connection portion 128. The distal connection portion 128 can be the portion of the haptics 104 that is distal from the peripheral fluid chamber 108 or haptic fluid chamber.

[0092] A section of the haptic 104 between the proximal end 126 and the distal connecting portion 128 (referred to herein as the chamber section 129) can be physically separated from the optical portion 102. The chamber section 129 can include at least a section of the peripheral fluid chamber 108 between the radially inner chamber wall 132 and the radially outer chamber wall 134. For example, the radially inner chamber wall 132 of the chamber section 129 can be separated from the optical portion 102 by an elongated gap or space. Figure 1A As shown in , the elongated gap or space may be a curved gap 130 .

[0093] The flex gap 130 can allow the peripheral fluid chamber 108 or the haptic fluid chamber to expand or change shape without the radially inner chamber wall 132 impacting or applying pressure to the side 111 of the optical portion 102 adjacent to the chamber segment 129 (see also, e.g., Figure 2A 、 Figure 2B 、 Figure 3A and Figure 3B ).

[0094] like Figure 1AAs shown in , the radially outer chamber wall 134 can be thicker or more massive than the radially inner chamber wall 132. In some embodiments, the radially outer chamber wall 134 can be thicker or more massive than both the radially inner chamber wall 132 and the peripheral fluid chamber 108.

[0095] When forces are applied to the lumen segments 129 in the radial direction by contraction or remodeling of the capsular bag, the thick or bulky radial outer chamber wall 134 can provide stiffness or elasticity to the lumen segments 129. For example, the thick or bulky radial outer chamber wall 134 can allow the lumen segments 129 of the peripheral portion 103 to be insensitive or less sensitive to radial forces applied to the peripheral portion 103 in the radial direction by capsular bag remodeling caused by movement of the ciliary muscles.

[0096] In some embodiments, the distal connection portion 128 may not be fixed or connected to adjacent segments of the optic portion 102, thereby allowing a greater amount of freedom for the haptics 104 to move for folding or unfolding purposes during implantation of the IOL 100. Once the IOL 100 is implanted within the capsular bag, the distal connection portion 128 may rest against or otherwise contact adjacent segments of the optic portion 102 to stabilize the haptics 104 and prevent the haptics 104 from twisting or otherwise moving around in response to capsular bag contraction or remodeling. In other embodiments, the haptics 104 may also be connected to the optic portion 102 at the distal connection portion 128.

[0097] like Figure 1A As shown in , the peripheral fluid chamber 108 can terminate before reaching the haptic distal portion 114. In some embodiments, the haptic distal arm(s) 116 can be made of the same material as the haptic chamber walls.

[0098] A technical problem faced by the applicants is how to design a fluid-filled IOL that can be adjusted post-operatively by a clinician or other medical professional, but that does not respond to or is therefore insensitive to radial forces applied to the fluid-filled IOL by the capsular bag. One solution discovered by the applicants is the accommodating IOL disclosed herein in which a peripheral fluid chamber extends only partially into the haptic of the accommodating IOL, and the chamber segment of the haptic has a radially outer chamber wall that is thicker than a radially inner chamber wall, and the radially inner chamber wall is separated from the optic by an elongated gap or space. The haptic can also be connected to the optic at a proximal end of the haptic and at a distal connection portion located distal to the chamber segment.

[0099] The peripheral portion 103 may include a composite material 400 (see, e.g., Figure 4A ), or at least a portion of the peripheral portion 103 can be made of a composite material 400. As will be discussed in more detail in the following sections, the composite material 400 can include an energy absorbing component 404 and a plurality of expandable components 406 (see, e.g., Figure 4A and Figure 4B ).

[0100] In some embodiments, the composite material 400 may be configured as a plurality of space fillers 310 (see, e.g., Figure 3A and 3B ) or piston. One or more of the space fillers 310 may be configured to respond to external energy 318 directed toward one or more of the space fillers 310 (see, e.g., Figure 3C ). The expansion of the one or more space fillers 310 can reduce the volume of the peripheral fluid chamber 108 that accommodates the one or more space fillers 310. At least one of the space fillers 310 can be configured as a pad extending from the chamber front wall 314 or the chamber rear wall 316 of the peripheral fluid chamber 108 (see, e.g., Figure 3B ).

[0101] In these and other embodiments, the composite material 400 can be configured as a plurality of chamber expanders 312 (see, e.g., Figure 3B ) or jacks. One or more of the chamber expanders 312 may be configured to respond to external energy 318 directed to one or more chamber expanders 312 (see, e.g., Figure 3D ). Expansion of the one or more chamber expanders 312 may increase the volume of the peripheral fluid chamber 108 housing the one or more chamber expanders 312. At least one of the chamber expanders 312 may be configured as an expandable column extending from a chamber front wall 314 to a chamber rear wall 316 of the peripheral fluid chamber 108 (see, e.g., Figure 3B ).

[0102] The base power or optical power / diopter of the optical portion 102 can be configured to respond to external energy 318 directed toward the composite material 400 (see, e.g., Figure 3C and 3D However, when the accommodating IOL 100 is implanted in the capsular bag, the base power of the optic portion 102 may be unresponsive or insensitive to the forces applied to the peripheral portion 103 by the capsular bag.

[0103] The base power of the optical portion 102 may be configured to change in response to displacement of fluid between the optical fluid chamber 106 and the peripheral fluid chamber 108 due to external energy 318 directed toward the composite material 400 .

[0104] The composite material 400 of the peripheral portion 103 can be formed, shaped, or otherwise configured into a plurality of discrete peripheral components 136. For example, each of the peripheral components 136 can be separated from adjacent or neighboring peripheral components 136 by a space or gap.

[0105] The peripheral component 136 can be positioned or located within the peripheral fluid chamber(s) 108. In some embodiments, the peripheral component 136 can occupy the entire chamber length of the peripheral fluid chamber 108. In other embodiments, the peripheral component 136 can occupy only a portion of the peripheral fluid chamber 108.

[0106] In some embodiments, directing external energy 318 toward one of peripheral components 136 may cause that particular peripheral component 136 to change its shape or expand without significantly affecting the other peripheral components 136. For example, directing external energy 318 toward one of peripheral components 136 may cause that particular peripheral component 136 to change its shape or expand without causing a similar shape change or expansion in the other peripheral components 136.

[0107] A pulse or set amount of external energy 318 can be directed to one peripheral component 136 to induce a change in the base power of the optical portion 102. In these embodiments, additional pulses or additional amounts of external energy 318 can be directed to another peripheral component 136 to induce another change in the base power of the optical portion 102.

[0108] In some embodiments, the peripheral portion 103 may include 20 to 40 peripheral components 136. In other embodiments, the peripheral portion 103 may include 10 to 20 peripheral components 136. In further embodiments, the peripheral portion 103 may include 40 to 60 peripheral components 136.

[0109] In some embodiments, one peripheral fluid chamber 108 may include 20 peripheral components 136. In other embodiments, one peripheral fluid chamber 108 may include 10 to 20 peripheral components 136. In still other embodiments, one peripheral fluid chamber 108 may include 20 to 30 peripheral components 136. In yet other embodiments, one peripheral fluid chamber 108 may include 5 to 10 peripheral components 136.

[0110] The peripheral components 136 may include one or more first peripheral components 138, one or more second peripheral components 140, or a combination thereof. The first peripheral component(s) 138 and the second peripheral component(s) 140 may be positioned or located within the same peripheral fluid chamber 108.

[0111] In some embodiments, one peripheral fluid chamber 108 can include at least ten first peripheral components 138. In other embodiments, one peripheral fluid chamber 108 can include five to ten first peripheral components 138 or ten to twenty first peripheral components 138.

[0112] In these and other embodiments, one peripheral fluid chamber 108 can include at least ten second peripheral components 140. In other embodiments, one peripheral fluid chamber 108 can include five to ten second peripheral components 140 or ten to twenty second peripheral components 140.

[0113] exist Figure 1A In the embodiment shown in FIG, one peripheral fluid chamber 108 may include ten first peripheral parts 138 and ten second peripheral parts 140. In addition, the accommodating IOL 100 may include two haptics 104, each haptic including a haptic fluid chamber having ten first peripheral parts 138 and ten second peripheral parts 140.

[0114] The first peripheral component 138 can be positioned within the peripheral fluid chamber 108 closer to the second peripheral component 140 (i.e., the second peripheral component 140 can be positioned deeper within the peripheral fluid chamber 108). For example, the first peripheral component 138 can be positioned closer to the fluid channel 110 connecting the optical fluid chamber 106 to the peripheral fluid chamber 108 than the second peripheral component 140. One reason for positioning the second peripheral component 140 (e.g., the chamber expander 312 or jack) deeper or farther within the peripheral fluid chamber 108 is to minimize mechanical stresses imposed on the optical portion 102 (which can cause undesirable aberrations) because expansion of the second peripheral component 140 affects the entire cross-section of the peripheral fluid chamber 108.

[0115] In other embodiments, at least some of the second peripheral components 140 can be positioned closer to or proximate to the fluid channel 110 than the first peripheral components 138. In still other embodiments, the first peripheral components 138 can be interleaved with the second peripheral components 140 such that the components form an alternating pattern.

[0116] exist Figure 1A In the embodiment shown in FIG, the peripheral components 136 (including the first peripheral component 138, the second peripheral component 140, or a combination thereof) can be arranged in a single row (e.g., a single curved row) along the length of the peripheral fluid chamber 108. In other embodiments not shown in the figures but contemplated by the present disclosure, the peripheral components 136 can be arranged in a zigzag pattern, a winding pattern, or a double or triple row pattern, i.e., two or more adjacent rows of peripheral components 136.

[0117] The base power of the optical portion 102 can be configured to change in response to fluid displacement between the optical fluid chamber 106 and the peripheral fluid chamber 108 due to external energy 318 directed toward the peripheral component(s) 136. For example, in response to the external energy 318 directed toward the peripheral component(s), the fluid can flow out of the peripheral fluid chamber 108 and into the optical fluid chamber 106 or out of the optical fluid chamber 106 and back into the peripheral fluid chamber 108.

[0118] The base power of the optical portion 102 can be configured to change in a first direction in response to external energy 318 directed toward the first peripheral portion 138. The base power of the optical portion 102 can also be configured to change in a second direction, opposite the first direction, in response to external energy 318 directed toward the second peripheral portion 140.

[0119] For example, the base power of the optical portion 102 can be configured to increase in response to external energy 318 directed toward the first peripheral component 138. As a more specific example, the fluid within the peripheral fluid chamber 108 can flow into the optical fluid chamber 106 in response to external energy directed toward the first peripheral component 138.

[0120] Furthermore, for example, the base power of the optical portion 102 can be configured to decrease in response to external energy 318 directed toward the second peripheral component 140. As a more specific example, the fluid within the optical fluid chamber 106 can flow into the peripheral fluid chamber 108 in response to the external energy directed toward the second peripheral component 140.

[0121] As will be discussed in more detail in the following sections, the first peripheral component 138 can be configured as a space filler 310 (see, for example, Figure 3A and 3B ) or a piston. The space filler 310 can be configured to expand in response to external energy 318 directed toward the space filler 310. The expansion of the space filler 310 can reduce the volume of the peripheral fluid chamber 108, which can thereby cause fluid to migrate from the peripheral fluid chamber 108 to the optical fluid chamber 106.

[0122] The second peripheral component 140 may be configured as a chamber expander 312 (see e.g. Figure 2B 、 Figure 3A and Figure 3B The chamber expander 312 may be configured to expand in response to external energy 318 directed toward the chamber expander 312. The expansion of the chamber expander 312 may increase the volume of the peripheral fluid chamber 108.

[0123] In some embodiments, the fluid within the optical fluid chamber 106, the peripheral fluid chamber(s) 108, or a combination thereof can be oil. More specifically, in some embodiments, the fluid within the optical fluid chamber 106, the peripheral fluid chamber(s) 108, or a combination thereof can be silicone oil or silicone fluid.

[0124] The fluid within the optical fluid chamber 106, the peripheral fluid chamber(s) 108, or a combination thereof can be a silicone oil or fluid comprising or consisting of diphenylsiloxane and dimethylsiloxane. In other embodiments, the silicone oil or fluid can comprise or consist of a ratio of two dimethylsiloxane units to one diphenylsiloxane unit. In certain embodiments, the silicone oil can comprise approximately 20 mol% diphenylsiloxane and approximately 80 mol% dimethylsiloxane.

[0125] More specifically, in some embodiments, the silicone oil can include diphenyltetramethylcyclotrisiloxane. In other embodiments, the silicone oil or silicone fluid can include or be made from a copolymer of diphenylsiloxane and dimethylsiloxane.

[0126] The fluid (e.g., silicone oil) can be index-matched to the lens body material used to manufacture the optical portion 102. When the fluid is index-matched to the lens body material, the entire optical portion 102 containing the fluid acts as a single lens. For example, the fluid can be selected to have a refractive index between about 1.48 and 1.53 (or between about 1.50 and 1.53). In some embodiments, the fluid (e.g., silicone oil) can have a polydispersity index between about 1.2 and 1.3. In other embodiments, the fluid (e.g., silicone oil) can have a polydispersity index between about 1.3 and 1.5. In other embodiments, the fluid (e.g., silicone oil) can have a polydispersity index between about 1.1 and 1.2. Other example fluids are described in U.S. Patent Publication No. 2018 / 0153682, which is incorporated herein by reference in its entirety.

[0127] Figure 1B The illustration shows that the adjustable static focus IOL 100 can be implanted within a natural capsular bag in which the natural lens has been removed. When implanted within the natural capsular bag, the optic portion 102 can be adapted to refract light entering the eye onto the retina. One or more haptics 104 (e.g., a first haptic 104A and a second haptic 104B) can be configured to engage the capsular bag to hold the accommodating IOL 100 in place within the capsular bag.

[0128] Figure 2AA perspective view of an accommodative IOL 100 is shown. As previously described, the optical fluid chamber 106 and the peripheral fluid chamber(s) 108 can be filled with a fluid (e.g., silicone oil). The base power of the optical portion 102 can be configured to change based on the internal fluid pressure within the fluid-filled optical fluid chamber 106.

[0129] The optical portion 102 can also be configured to change shape in response to fluid entering the optical fluid chamber 106. In some embodiments, the front element 200 of the optical portion 102 can be configured to change shape in response to fluid entering or leaving the optical fluid chamber 106. For example, the front element 200 can be configured to increase its curvature in response to fluid entering the optical fluid chamber 106. Additionally, for example, the front element 200 can be configured to decrease its curvature in response to fluid leaving the optical fluid chamber 106.

[0130] In other embodiments, the posterior element 300 of the optical portion 102 (see, e.g., Figure 3A and Figure 3B ) can be configured to change shape (e.g., increase its curvature or decrease its curvature) in response to fluid entering or leaving the optical fluid chamber 106. In still other embodiments, both the front element 200 and the rear element 300 can be configured to change shape in response to fluid entering or leaving the optical fluid chamber 106.

[0131] The base power of the optical portion 102 can be configured to increase or decrease in response to the shape change(s) experienced by the anterior element 200, the posterior element 300, or a combination thereof. Increasing the curvature of the anterior element 200, the posterior element 300, or a combination thereof can increase the base power of the optical portion 102, thereby allowing better near vision. Decreasing the curvature of the anterior element 200, the posterior element 300, or a combination thereof can decrease the base power of the optical portion 102, thereby allowing better distance vision.

[0132] For example, the base power of the optical portion 102 can be configured to increase as fluid enters the optical fluid chamber 106 from the peripheral fluid chamber(s) 108 (e.g., the haptic fluid chamber(s)). Fluid can flow from the peripheral fluid chamber(s) 108 into the optical fluid chamber 106 when the volume of the peripheral fluid chamber(s) 108 decreases in response to expansion of one or more of the first peripheral components 138. One or more of the first peripheral components 138 can expand in response to external energy 318 directed toward the first peripheral component(s) 138.

[0133] Furthermore, for example, the base power of the optical portion 102 can be configured to decrease as fluid exits or is drawn from the fluid-filled optical fluid chamber 106 into the peripheral fluid chamber(s) 108. Fluid can flow from the optical fluid chamber 106 into the peripheral fluid chamber(s) 108 as the volume of the peripheral fluid chamber(s) 108 increases in response to expansion of one or more of the second peripheral components 140. One or more of the second peripheral components 140 can expand in response to external energy 318 directed toward the second peripheral component(s) 140.

[0134] Figure 2B A perspective view of an accommodating IOL 100 is shown with a portion of the front of the accommodating IOL 100 removed to better illustrate the components within the IOL. The accommodating IOL 100 can include a peripheral portion 103 that includes a plurality of peripheral components 136 within a peripheral fluid chamber(s) 108. For example, portions of the peripheral portion 103 can be formed as the peripheral components 136.

[0135] like Figure 2B , the optical fluid chamber 106 can be in fluid communication with each peripheral fluid chamber 108 via a fluid channel 110. The fluid channel 110 can be a conduit or passageway that connects the optical fluid chamber 106 to the peripheral fluid chamber(s) 108 or the tactile fluid chamber(s). Although a single fluid channel 110 is shown connecting the optical fluid chamber 106 to each peripheral fluid chamber 108, the present disclosure contemplates that multiple fluid channels (e.g., two fluid channels) can connect the optical fluid chamber 106 to each peripheral fluid chamber 108.

[0136] The base power of the optical portion 102 can be configured to change (eg, increase or decrease) in response to external energy 318 directed to the peripheral components 136 . As previously described, each of the peripheral components 136 can be made of the composite material 400 .

[0137] As will be discussed in more detail in the following sections, each of the first peripheral components 138 can be configured as a space filler 310 (see also, eg, 3A, Figure 3B and Figure 3C The space filler 310 may be configured to expand in response to external energy directed toward the space filler 310. The expansion of the space filler 310 may reduce the volume of the peripheral fluid chamber 108 and cause fluid to flow from the peripheral fluid chamber 108 into the optical fluid chamber 106.

[0138] Each of the second peripheral components 140 may be configured as a chamber expander 312 (see also e.g. Figure 3B and Figure 3D The chamber expander 312 may be configured to expand in response to external energy directed toward the chamber expander 312. Expansion of the chamber expander 312 may increase the volume of the peripheral fluid chamber 108 by expanding the peripheral fluid chamber 108 and causing fluid to flow or be drawn from the optical fluid chamber 106 into the peripheral fluid chamber 108.

[0139] The optical fluid chamber 106 and the peripheral fluid chamber(s) 108 may include or hold a fluid (e.g., silicone oil) having a total fluid volume between about 10 μL and about 20 μL. For example, the optical fluid chamber 106 and the peripheral fluid chamber(s) 108 may include a fluid (e.g., silicone oil) having a total fluid volume of about 15 μL.

[0140] exist Figure 2B In the embodiment shown in , peripheral portion 103 can include first haptic body 104A and second haptic body 104B. First haptic body 104A can have a first haptic fluid chamber and second haptic body 104B can have a second haptic fluid chamber. Each of the first haptic fluid chamber and the second haptic fluid chamber can be considered to be one of peripheral fluid chambers 108. In this embodiment, each of the haptic fluid chambers (e.g., each of the first haptic fluid chamber and the second haptic fluid chamber) can include or hold a fluid having a fluid volume between approximately 0.3 μL and 0.6 μL (or approximately 0.5 μL).

[0141] In some embodiments, between approximately 10 nanoliters (nL) and 20 nL of fluid may be exchanged and displaced between the peripheral fluid chamber 108 (e.g., the first tactile fluid chamber or the second tactile fluid chamber) and the optical fluid chamber 106 in response to a pulse of external energy 318 directed toward one of the peripheral components 136. More specifically, approximately 15 nL of fluid may be exchanged and displaced between one or more peripheral fluid chambers 108 (e.g., the first tactile fluid chamber or the second tactile fluid chamber) and the optical fluid chamber 106 in response to a pulse of external energy 318 directed toward one of the peripheral components 136.

[0142] In some embodiments, the base power of the optical portion 102 can be configured to vary between about 0.05 diopters (D) and about 0.5 D in a positive or negative direction in response to a pulse of external energy 318 directed to one of the peripheral components 136. For example, the base power of the optical portion 102 can be configured to vary by about 0.1 D in response to a pulse of external energy 318 directed to one of the peripheral components 136.

[0143] The change in the base power of the optical portion 102 can be a permanent or substantially permanent change. A permanent or substantially permanent change can mean that the peripheral component 136 does not substantially return to its original shape or size after the change has occurred.

[0144] In certain embodiments, the base power of the optical portion 102 can be configured to vary in either the positive or negative direction by a total of between about 1.0 D and about 2.0 D. In these embodiments, the total power variation can be determined by the total number of peripheral components 136, the size and / or expandability of the peripheral components 136, the chamber volume of the peripheral fluid chamber 108 and / or the optical fluid chamber 106, the volume of oil within such chambers, or a combination thereof.

[0145] In other embodiments, the base power of the optical portion 102 can be configured to vary between approximately 2.0D and approximately 3.0D in either the positive or negative direction, in total. In further embodiments, the base power of the optical portion 102 can be configured to vary between approximately 3.0D and approximately 5.0D in either the positive or negative direction, in total. In still other embodiments, the base power of the optical portion 102 can be configured to vary between approximately 5.0D and approximately 10.0D in either the positive or negative direction, in total.

[0146] In some embodiments, the optical portion 102 can have an unfilled or as-manufactured optical power (i.e., the optical power of the optical portion 102 when the optical fluid chamber 106 is empty or unfilled) of between about 11 D and 13 D (a "zero-power" lens). For example, the optical portion 102 can have an unfilled or as-manufactured optical power of about 12 D. The optical power of the optical portion 102 can increase as the optical fluid chamber 106 is filled with a fluid (e.g., silicone oil).

[0147] The optical fluid chamber 106 can be filled until the base power of the filled optical portion 102 (contributed by both the fluid of the optical portion 102 and the lens surface) is between about 15D (low-power IOL) and about 30D (high-power IOL). For example, the optical fluid chamber 106 can be filled until the base power of the filled optical portion 102 is about 20D.

[0148] The accommodating IOL 100 implanted within the capsular bag of a subject can have a base power between about 15 D and about 30 D, e.g., about 20 D. When the accommodating IOL 100 is implanted within the capsular bag of a subject, a clinician or medical professional can direct external energy 318 (e.g., laser light) to the peripheral member 136 to increase or decrease the base power of the optic portion 102.

[0149] For example, when implanted in a subject's eye, accommodating IOL 100 may have a base power of approximately 20 D. If power correction is desired to increase the power of the lens, the clinician or medical professional may direct external energy 318 to each of first peripheral components 138 to incrementally increase the base power of optical portion 102 between approximately +0.1 D and +0.2 D, until the final base power is between approximately 21 D (for a total change of +1.0 D) and 22 D (for a total change of +2.0 D).

[0150] In other embodiments, the clinician or medical professional can direct external energy 318 to each of the first peripheral components 138 to incrementally increase the base power of the optical portion 102 between approximately +0.1D and +0.2D, until the final base power is between approximately 22D (for a total change of +2.0D) and 25D (for a total change of +5.0D).

[0151] As another example, when implanted in the eye of a subject, accommodating IOL 100 may have a base power of approximately 25 D. If power correction is needed to reduce the power of the lens, the clinician or medical professional may direct external energy 318 to each of second peripheral components 140 to gradually reduce the base power of optical portion 102 between approximately -0.1 D and -0.2 D, until the final base power is between approximately 24 D (a total change of -1.0 D) and 23 D (a total change of -2.0 D).

[0152] In other embodiments, the clinician or medical professional can direct external energy 318 to each of the second peripheral components 140 to gradually reduce the base power of the optical portion 102 between approximately -0.1D and -0.2D, until the final base power is between approximately 23D (a total change of -2.0D) and 20D (a total change of -5.0D).

[0153] In some embodiments, the accommodating IOL 100 can have an optical sensitivity of between about 100 nL and 200 nL (e.g., about 150 nL) of fluid displacement per diopter. That is, when about 100 nL to 200 nL (e.g., about 150 nL) of fluid is displaced between the peripheral fluid chamber 108 and the optical fluid chamber 106, the base power of the optical portion 102 can change by about 1.0 D. As a more specific example, when between about 100 nL and 200 nL (e.g., about 150 nL) of fluid is displaced from the peripheral fluid chamber 108 into the optical fluid chamber 106 due to external energy 318 directed toward the first peripheral member 138, the base power of the optical portion 102 can increase by +1 D. Furthermore, when between about 100 nL and 200 nL (e.g., about 150 nL) of fluid leaves or is drawn out of the optical fluid chamber 106 into the peripheral fluid chamber 108 due to external energy 318 directed toward the second peripheral component 140, the base power of the optical portion 102 can decrease by -1.0D.

[0154] In some embodiments, each of the peripheral fluid chambers 108 can include ten first peripheral components 138 and ten second peripheral components 140. In these embodiments, directing external energy 318 to each of the first peripheral components 138 or each of the second peripheral components 140 can cause between approximately 10 nL and 20 nL (e.g., approximately 15 nL) of fluid to be displaced or exchanged between the optical fluid chamber 106 and the peripheral fluid chamber 108. For example, directing external energy 318 to one of the first peripheral components 138 can cause the first peripheral component 138 to expand and reduce the volume of the peripheral fluid chamber 108 containing the first peripheral component 138. This can cause between approximately 10 nL and approximately 20 nL (e.g., approximately 15 nL) of fluid to flow from the peripheral fluid chamber 108 into the optical fluid chamber 106. Additionally, for example, directing external energy 318 to one of the second peripheral components 140 can cause the second peripheral component 140 to expand and increase the volume of the peripheral fluid chamber 108 containing the second peripheral component 140. This may result in between about 10 nL and about 20 nL (eg, about 15 nL) of fluid being drawn from the optical fluid chamber 106 into the peripheral fluid chamber 108 .

[0155] The accommodating IOL 100 can be configured such that the base power of the optic portion 102 changes due to this fluid exchange or displacement by between approximately 0.05 D and 0.5 D. As a more specific example, in response to approximately 15 nL of fluid being displaced or exchanged between the optical fluid chamber 106 and the peripheral fluid chamber 108, the base power of the optic portion 102 can change by approximately 0.1 D.

[0156] Figure 3A The diagram shows the Figure 2AThe optic portion 102 may include an anterior element 200 and a posterior element 300. A fluid-filled optical fluid chamber 106 may be defined between the anterior element 200 and the posterior element 300.

[0157] The front element 200 may include a front optical surface and a front inner surface opposite the front optical surface. The rear element 300 may include a rear optical surface and a rear inner surface opposite the rear optical surface. Any of the front optical surface, the rear optical surface, or a combination thereof may be considered and referred to as an external optical surface. The front inner surface and the rear inner surface may face the optical fluid chamber 106. At least a portion of the front inner surface and at least a portion of the rear inner surface may serve as chamber walls of the optical fluid chamber 106. In some embodiments, the peripheral portion 103 (e.g., the haptic 104) may be connected to or may extend from at least a portion of the rear element 300 of the optical portion 102.

[0158] As will be discussed in more detail in the following sections, accommodative IOL 100 can have a lens surface profile or pattern (e.g., a beam splitting lens profile or pattern) defined on an external optical surface. For example, the lens surface profile can include a diffractive surface profile or pattern or a phase-shifting structure or profile. The lens surface profile or pattern can allow accommodative IOL 100 to be adapted to different use cases, such as providing a focus (monofocal) for a specific distance or providing a focus (multifocal) for multiple distances. For example, depending on the lens surface profile or pattern defined on the external optical surface, accommodative IOL 100 can be configured as an accommodative monofocal IOL, an accommodative multifocal IOL (e.g., an accommodative bifocal or trifocal IOL), or an accommodative extended depth of focus (EDOF) intraocular lens.

[0159] The optical portion 102 can be configured to deform, flex, or otherwise change shape in response to fluid entering or leaving the optical fluid chamber 106. In some embodiments, the front element 200 can be configured to deform, flex, or otherwise change shape (e.g., change its curvature) in response to fluid entering or leaving the optical fluid chamber 106. In other embodiments, the rear element 300 can be configured to deform, flex, or otherwise change shape (e.g., change its curvature) in response to fluid entering or leaving the optical fluid chamber 106. In yet other embodiments, both the front element 200 and the rear element 300 can be configured to deform, flex, or otherwise change shape (e.g., change its curvature) in response to fluid entering or leaving the optical fluid chamber 106. The base power of the optical portion 102 can be configured to change in response to the shape change experienced by the shape-changing component of the optical portion 102 (e.g., the front element 200, the rear element 300, or a combination thereof).

[0160] The optical portion 102 can be made in part of a deformable or flexible material. In some embodiments, the optical portion 102 can be made in part of a deformable or flexible polymeric material. For example, the anterior element 200, the posterior element 300, or a combination thereof can be made in part of a deformable or flexible polymeric material. At least a portion of the peripheral portion 103, such as one or more haptics 104 (e.g., the first haptic 104A, the second haptic 104B, or a combination thereof) can be made of the same deformable or flexible material as the optical portion 102. In other embodiments, one or more haptics 104 can be made in part of a different material than the optical portion 102.

[0161] In some embodiments, portions of the optical portion 102 and the peripheral portion 103 that are not made of the composite material 400 may include or be made in part of a polymer or a cross-linked copolymer including a copolymer blend.

[0162] For example, in some embodiments, the copolymer blend can include alkyl acrylates or methacrylates, fluoro-alkyl (meth)acrylates, phenyl alkyl acrylates, or combinations thereof. This disclosure contemplates and those of ordinary skill in the art will appreciate that these types of acrylic cross-linked copolymers can generally be copolymers of multiple acrylates or methacrylates. Unless otherwise indicated, the term "acrylate" as used herein can be understood to refer to either acrylate or methacrylate.

[0163] For example, the portions of the optical portion 102 and the peripheral portion 103 that are not made of the composite material 400 can be made of a hydrophobic acrylic material. For example, the hydrophobic acrylic material can include a hydrophobic acrylate / methacrylate copolymer. In some embodiments, the hydrophobic acrylic material can include a combination of phenylethyl acrylate (PEA) and phenylethyl methacrylate (PEMA).

[0164] In one exemplary embodiment, the cross-linked copolymer may include an alkyl acrylate in an amount of about 3% to 20% (wt%), a fluoroalkyl acrylate in an amount of about 10% to 35% (wt%), and a phenyl alkyl acrylate in an amount of about 50% to 80% (wt%). In some embodiments, the cross-linked copolymer may include or be partially made of n-butyl acrylate as the alkyl acrylate, trifluoroethyl methacrylate as the fluoroalkyl acrylate, and phenylethyl acrylate as the phenyl alkyl acrylate. More specifically, the cross-linked copolymer may include n-butyl acrylate in an amount of about 3% to 20% (wt%) (e.g., between about 12% and 16%), trifluoroethyl methacrylate in an amount of about 10% to 35% (wt%) (e.g., between about 17% and 21%), and phenylethyl acrylate in an amount of about 50% to 80% (wt%) (e.g., between about 64% and 67%).

[0165] The final composition of the cross-linked copolymer may further comprise a cross-linker or cross-linking agent, such as ethylene glycol dimethacrylate (EGDMA). For example, the final composition of the cross-linked copolymer may further comprise a cross-linker or cross-linking agent (e.g., EGDMA). The final composition of the cross-linked copolymer may further comprise an initiator or initiator (e.g., Perkadox 16, camphorquinone, 1-phenyl-1,2-propanedione, and 2-ethylhexyl-4-(dimethylamino)benzoate)) and a UV absorber.

[0166] In some embodiments, the refractive index of the material used to fabricate the optical portion 102 can be between about 1.48 and about 1.53. In certain embodiments, the refractive index of the material used to fabricate the optical portion 102 can be between about 1.50 and about 1.53.

[0167] In some embodiments, portions of the optical portion 102 and the peripheral portion 103 that are not made of the composite material 400 may include a reactive (polymerizable) UV absorber and a reactive blue light absorber. For example, the reactive UV absorber may be or include 2-(2'-hydroxy-3'-methallyl-5'-methylphenyl)benzotriazole (which is commercially available as o-methylallyl Tinuvin P ("oMTP") from Polysciences, Inc., located in Warrington, Pennsylvania), 3-(2H-benzo[d][1,2,3]triazol-2-yl)-4-hydroxyphenethyl methacrylate, and 2-(3-(tert-butyl)-4-hydroxy-5-(5-methoxy-2H-benzo[d][1,2,3]triazol-2-yl)phenoxy)ethyl methacrylate. In certain embodiments, the reactive UV absorber is present in an amount of about 0.1% to 5% (wt%). When present, the reactive UV absorber is typically present in an amount of about 1.5% to 2.5% (wt%) or about 1.5% to 2% (wt%).

[0168] In certain embodiments, the reactive blue-light absorbing compound may be those described in U.S. Patent Nos. 5,470,932; 8,207,244; and 8,329,775, the entire contents of which are incorporated herein by reference. For example, the blue-light absorbing dye may be N-2-[3-(2'-methylphenylazo)-4-hydroxyphenyl]ethyl methacrylamide. When present, the blue-light absorber is typically present in an amount of about 0.005% to 1% (wt%), or about 0.01% to 0.1% (wt%).

[0169] Figure 3B The diagram shows the Figure 2A Cross-sectional view of the adjustable IOL taken from the BB cross section. Figure 3B As shown in , the peripheral fluid chamber 108 can have a chamber height 302. In some embodiments, the chamber height 302 can be about 0.1 mm. In other embodiments, the chamber height 302 can be between about 0.1 mm and 0.3 mm.

[0170] In other embodiments, the chamber height 302 can be between approximately 0.3 mm and 1.0 mm. In still other embodiments, the chamber height 302 can be between approximately 1.0 mm and 1.5 mm.

[0171] Figure 3B Also shown is that the side 111 of the optical portion 102 can have a side height 304 (as measured in the front-to-back direction). In some embodiments, the side height 304 can be between about 0.50 mm and 0.75 mm. For example, the side height 304 can be about 0.65 mm. In other embodiments, the side height 304 can be between about 0.40 mm and 0.50 mm or between about 0.75 mm and 1.25 mm.

[0172] The peripheral portion 103 may also have a peripheral portion height 306 (also referred to as a tactile height or thickness). In some embodiments, the peripheral portion height 306 may be between approximately 0.50 mm and 0.60 mm. In other embodiments, the peripheral portion height 306 may be between approximately 0.60 mm and 0.65 mm or between approximately 0.45 mm and 0.50 mm.

[0173] like Figure 3B , the side height 304 of the side 111 of the optical portion 102 can be greater than the peripheral portion height 306. For example, when the peripheral portion 103 includes one or more haptics, the thickness or height of the haptics (as measured in the anterior to posterior direction) can be less than the thickness or height of the optical portion 102 along all sections of the optical portion 102.

[0174] In some embodiments, peripheral portion height 306 or thickness (in the front-to-back direction) can be substantially uniform, such that no portion of peripheral portion 103 is taller or thicker than any other portion of peripheral portion 103. When peripheral portion 103 includes multiple haptics 104, all haptics 104 can have the same height or thickness.

[0175] Figure 3B Also illustrated is that the front element 200 can have a front element thickness 308 (as measured in the front to rear direction). In some embodiments, the front element thickness 308 can be between about 0.15 mm and about 0.25 mm. For example, the front element thickness 308 can be about 0.20 mm.

[0176] Figure 3A and Figure 3B Also illustrated is that the first peripheral component 138 can be configured as a space filler 310. The space filler 310 can be configured to expand in response to external energy 318 directed toward the space filler 310. The expansion of the space filler 310 can reduce the volume of the peripheral fluid chamber 108.

[0177] As a more specific example, the space filler 310 can be implemented as an expandable pad extending from at least one of the chamber front wall 314 and the chamber back wall 316. The base power of the optical portion 102 can be configured to increase in response to external energy 318 directed toward the space filler 310, thereby causing fluid to move out of the peripheral fluid chamber 108 due to the increase in volume of the space filler 310.

[0178] Figure 3B It is also illustrated that the second peripheral component 140 can be configured as a chamber expander 312. The chamber expander 312 can be configured to expand in response to external energy 318 directed toward the chamber expander 312. The expansion of the chamber expander 312 can increase the volume of the peripheral fluid chamber 108.

[0179] As a more specific example, the chamber expander 312 can be implemented as an expandable column extending from the chamber front wall 314 to the chamber back wall 316. Expansion of the expandable column can increase the volume of the peripheral fluid chamber 108. The base power of the optical portion 102 can be configured to decrease in response to external energy 318 directed toward the expandable column, thereby causing expansion of the chamber expander 312 and an increase in the volume of the peripheral fluid chamber 108.

[0180] Figure 3C It is illustrated that external energy 318 may be directed to the space-filling 310 of the accommodating IOL 100 to cause a shape change in the space-filling 310 .

[0181] The first peripheral component 138 may be made of the composite material 400. The first peripheral component 138 may be positioned within the peripheral fluid chamber 108.

[0182] In some embodiments, the composite material 400 used to fabricate the first peripheral component 138 can be cured within the peripheral fluid chamber 108 along with the remaining materials used to construct the peripheral fluid chamber 108. In these embodiments, the first peripheral component 138 can be cured in place within the peripheral fluid chamber 108.

[0183] In other embodiments, an adhesive may be used to adhere the first peripheral member 138 to the inner wall or surface of the peripheral fluid chamber 108. The adhesive may be cured to secure the first peripheral member 138 to the inner wall or surface of the peripheral fluid chamber 108.

[0184] The first peripheral component 138 can be configured as a space filler 310. In some embodiments, the space filler 310 can be implemented as an expandable disc-shaped cushion (see, for example, Figure 2B 、 Figure 3A and Figure 3B While the figures illustrate the space filler 310 as being shaped as a generally flat cylinder or disk, the present disclosure contemplates that the space filler 310 may be shaped generally as a sphere, hemisphere, oval, ellipsoid, cuboid, or other polyhedron, or combinations thereof.

[0185] The space filler 310 may extend from, adhere to, or otherwise couple to the chamber front wall 314 or the chamber back wall 316. In some embodiments, when the peripheral fluid chamber 108 includes multiple space fillers 310, at least one of the space fillers 310 may extend from, adhere to, or otherwise couple to the chamber front wall 314, and another of the space fillers 310 may extend from, adhere to, or otherwise couple to the chamber back wall 316.

[0186] In other embodiments, the space filler 310 may extend from, adhere to, or otherwise couple to the chamber inner sidewall 320 .

[0187] like Figure 3C , the space filler 310 can expand in response to a burst of external energy 318 directed toward the space filler 310. The expansion of the space filler 310 can reduce the internal volume of the peripheral fluid chamber 108 and displace fluid from the peripheral fluid chamber 108 into the optical fluid chamber 106. The base power of the optical portion 102 can be configured to increase in response to the external energy 318 directed toward the space filler 310.

[0188] Figure 3C It is illustrated that the size of the space filler 310 may be adjusted so that the space filler 310 does not contact the chamber inner sidewall 320 . Figure 3C Also illustrated is that a separation distance 322, or gap, can be maintained between the space filler 310 and each of the chamber inner sidewalls 320 even when the space filler 310 expands in response to external energy 318 directed toward the space filler 310. This ensures that the expanded space filler 310 does not expand the peripheral fluid chamber 108 or expand the peripheral fluid chamber 108 to an extent that would offset the effect of the expanded space filler 310 on reducing the volume of the peripheral fluid chamber 108. Furthermore, the front-to-back height of the space filler 310 can be significantly less than the chamber height 302, such that the expanded space filler 310 does not contact the chamber front wall 314.

[0189] In some embodiments, external energy 318 may be light energy. More specifically, external energy 318 may be laser energy. External energy 318 may be a burst of laser energy.

[0190] In some embodiments, the laser light may have a wavelength between about 488 nm and about 650 nm. For example, the laser light may be a green laser light. A green laser light may have a wavelength between about 520 nm and about 570 nm. In one example embodiment, the external energy 318 may be a green laser light having a wavelength of about 532 nm.

[0191] For example, the laser light may be that emitted by an ophthalmic laser.For example, the laser light may be that emitted by a retinal coagulation laser.

[0192] In some embodiments, the laser light may be emitted by a neodymium-doped yttrium aluminum garnet (Nd:YAG) laser. As a more specific example, the laser light may be a pulsed Nd:YAG laser that is operated in a Q-switched mode and frequency doubled to generate 532 nm laser light.

[0193] In other embodiments, the laser light may be emitted by a femtosecond laser or an infrared or near-infrared laser. For example, the laser light emitted by such a laser may have a wavelength between approximately 1030 nm and 1064 nm.

[0194] As will be discussed in more detail in the following sections, when the external energy 318 is light energy, the energy absorbing component 404 (see Figure 4A ) can absorb or otherwise capture light energy and convert it into heat energy and transfer the heat energy to the expandable member 406 within the composite material 400 (see Figure 4A and Figure 4B ) to expand the expandable component 406.

[0195] As previously described, in some embodiments, approximately 15 nL of fluid can flow from the peripheral fluid chamber 108 (through the fluid channel 110) into the optical fluid chamber 106 in response to expansion of one of the space fillers 310. In these and other embodiments, the base power of the optical portion 102 can be configured to change by approximately +0.1D in response to a pulse of external energy 318 directed toward one of the space fillers 310.

[0196] Figure 3D It is illustrated that external energy 318 may be directed to the second peripheral component 140 of the accommodating IOL 100 to cause a shape change in the second peripheral component 140 .

[0197] The second peripheral component 140 may be made of the composite material 400. The second peripheral component 140 may be positioned within the peripheral fluid chamber 108.

[0198] In some embodiments, the composite material 400 used to fabricate the second peripheral component 140 can be cured within the peripheral fluid chamber 108 along with the remaining materials used to construct the peripheral fluid chamber 108. In these embodiments, the second peripheral component 140 can be cured in place within the peripheral fluid chamber 108.

[0199] In other embodiments, an adhesive may be used to adhere the second peripheral component 140 to the inner wall or surface of the peripheral fluid chamber 108. The adhesive may be cured to cure the second peripheral component 140 to the inner wall or surface of the peripheral fluid chamber 108.

[0200] The second peripheral component 140 can be configured as a chamber expander 312. In some embodiments, the chamber expander 312 can be implemented as an expandable column extending from the chamber front wall 314 to the chamber rear wall 316 (see, e.g., Figure 3B While the figures illustrate the chamber expander 312 as being shaped as a substantially elongated cylinder, the present disclosure contemplates that the chamber expander 312 may be shaped substantially as an elongated oval, an elongated ellipsoid, an elongated cuboid or other polyhedron, a cone, a truncated cone, or combinations thereof.

[0201] As a more specific example, the chamber expander 312 can be implemented as an expandable column extending from the chamber front wall 314 to the chamber back wall 316. Expansion of the expandable column can increase the volume of the peripheral fluid chamber 108 by pushing on one or both of the chamber inner wall 314 and the chamber back wall 316 to increase the chamber height 302. The base power of the optical portion 102 can be configured to decrease in response to external energy 318 directed toward the expandable column.

[0202] like Figure 3D, the chamber expander 312 can expand in response to a burst of external energy 318 directed toward the chamber expander 312. The expansion of the chamber expander 312 can increase the volume of the peripheral fluid chamber 108 and draw fluid from the optical fluid chamber 106 into the peripheral fluid chamber 108. The base power of the optical portion 102 can be configured to decrease in response to the external energy 318 directed toward the chamber expander 312.

[0203] The external energy 318 can be the same external energy 318 as previously disclosed. For example, the external energy 318 can be light energy.

[0204] Figure 3D The chamber expander 312 is shown to be sized so that the chamber expander 312 does not contact (even when expanded) the chamber interior sidewalls 320. This ensures that the enlarged chamber expander 312 expands the peripheral fluid chamber 108 primarily in the anterior-to-posterior direction and does not exert pressure on the radially inner chamber walls 132 (which could then translate into pressure applied to the sides of the optical portion 102, thereby inadvertently affecting optical power).

[0205] As previously described, in some embodiments, approximately 15 nL of fluid can flow from the optical fluid chamber 106 (through the fluid channel 110) into the peripheral fluid chamber 108 in response to a pulse of external energy 318 directed toward one of the chamber expanders 312. In these and other embodiments, the base power of the optical portion 102 can be configured to change by approximately -0.1D in response to expansion of one of the chamber expanders 312 caused by the external energy 318 directed toward the chamber expander 312.

[0206] Although Figure 1A 、 Figure 1B 、 Figure 2B and Figure 5 Each peripheral fluid chamber 108 (e.g., each tactile fluid chamber) is illustrated as including both a space filler 310 and a chamber expander 312, but the present disclosure contemplates and one of ordinary skill in the art will understand that each peripheral fluid chamber 108 may also include only a space filler 310 or only a chamber expander 312.

[0207] One technical problem faced by the applicant is how to provide a clinician or other medical professional with the ability to fine-tune the optical power of an implanted IOL in two directions (i.e., to provide the clinician with the ability to increase or decrease the optical power of an implanted IOL post-operatively). One solution discovered by the applicant is the peripheral component disclosed herein, comprising, for example, a space filler and a chamber expander made of a composite material. As a more specific example, each peripheral fluid chamber (or tactile fluid chamber) can include a plurality of space fillers, chamber expanders, or both space fillers and chamber expanders. Each peripheral component can be configured to change the optical portion of the adjustable IOL by approximately 0.1D in response to a burst of external energy directed toward the peripheral component.

[0208] Figure 4A is an illustration of a composite material 400 that includes a composite substrate 402, an energy absorbing component 404, and a plurality of expandable components 406. As previously described, at least a portion of the peripheral portion 103 or components within the peripheral portion 103 can be made of the composite material 400.

[0209] The composite substrate 402 can be made of a hydrophobic acrylic material. For example, the composite substrate 402 can be made of phenethyl acrylate (PEA), phenethyl methacrylate (PEMA), or a combination thereof.

[0210] In one exemplary embodiment, composite substrate 402 may include a methacrylate-functional or methacrylic acid-functional crosslinkable polymer and a reactive acrylic monomer diluent including lauryl methacrylate (n-dodecyl methacrylate or SR313) and ADMA. By controlling the amount of lauryl methacrylate (SR313) relative to ADMA, the overall hardness (i.e., more ADMA) or softness (i.e., more SR313) of the cured composite material 400 may be controlled. The methacrylate-functional or methacrylic acid-functional crosslinkable polymer may be prepared using a crosslinkable polymer precursor formulation.

[0211] The cross-linkable polymer precursor formulation can comprise the same copolymer blend used to make the optics and haptics.

[0212] The copolymer blend may comprise an alkyl acrylate or alkyl methacrylate (e.g., n-butyl acrylate), an alkyl fluoro(meth)acrylate (e.g., trifluoroethyl methacrylate), and an alkyl phenyl acrylate (e.g., phenylethyl acrylate). For example, the copolymer blend may comprise n-butyl acrylate in an amount of about 41% to about 45% (wt%), trifluoroethyl methacrylate in an amount of about 20% to about 24% (wt%), and phenylethyl acrylate in an amount of about 28% to about 32% (wt%). The crosslinkable polymer precursor formulation may comprise or may be made in part of the copolymer blend, a hydroxyl-functional acrylic monomer (e.g., HEA), and a photoinitiator (e.g., Darocur 4265 or a 50 / 50 blend of a diphenyl mixture (2,4,6-trimethylbenzoyl)-phosphine oxide and 2-hydroxy-2-methylpropiophenone).

[0213] The composite substrate 402 may include a methacrylate-functional or methacrylic acid-functional crosslinkable polymer (as described above) in an amount of about 50% to about 65% (e.g., about 55% to about 60%) (wt%), a reactive acrylic monomer diluent of lauryl methacrylate (SR313) in an amount of about 32% to about 38% (e.g., about 32.70%) (wt%), and a reactive acrylic monomer diluent of methylene methacrylate (ADMA) in an amount of about 5% to about 9% (e.g., about 7.30%) (wt%).

[0214] Table 1 below provides an example formulation of composite material 400:

[0215] Table 1: Formulation of composite materials (WT%)

[0216]

[0217] Composite material 400 can be made in several operations. A first operation can include preparing an uncolored composite substrate 402. A second operation can include mixing composite substrate 402 with an energy absorbing component 404, an expandable component 406, and an initiator (such as one or more photoinitiators), a thermal initiator, or a combination thereof. A third operation can include placing uncured composite material 400 into a desired location within peripheral portion 103 (e.g., peripheral fluid chamber 108 and / or haptic(s) 104) and curing composite material 400 in place.

[0218] For example, the uncolored composite substrate 402 may be mixed with an energy absorbing component 404, such as a dye (eg, Disperse Red 1 dye) or a pigment (graphitized carbon black). The energy absorbing component 404 will be discussed in more detail below.

[0219] In some embodiments, expandable component 406 can comprise from about 5.0% to about 15.0% by weight of the final formulation of composite material 400. More specifically, expandable component 406 can comprise from about 8.0% to about 12.0% (e.g., about 10.0%) by weight of the final formulation of composite material 400 (see Table 1). In these and other embodiments, energy absorbing component 404 can comprise from about 0.044% to about 0.44% (or about 0.55%) by weight of the final formulation of composite material 400.

[0220] The photoinitiator can be Omnirad 2022 (bis(2,4,6-trimethylbenzoyl)phenyl-phosphine oxide / 2-hydroxy-2-methyl-1-phenyl-propan-1-one). The photoinitiator can constitute about 1.30% by weight of the final formulation of the composite material 400 (see, e.g., Table 1). In addition, the composite material 400 can also include a thermal initiator. The thermal initiator can constitute about 1.00% by weight of the final formulation of the composite material 400 (see, e.g., Table 1). In some embodiments, the thermal initiator can be a dialkyl peroxide, such as Peroxide. In other embodiments, the thermal initiator can be Perkadox.

[0221] In some embodiments, an energy absorbing component (e.g., a dye or pigment) can be positioned or located adjacent to the uncolored composite substrate 402. In this embodiment, the energy absorbing component 404 can absorb external energy 318 (e.g., laser energy), convert the energy into heat, and conduct the energy to the composite substrate 402 to expand the composite substrate 402. An additional benefit of this approach is that the energy absorbing component 404 can be made more discrete and easier for a clinician or surgeon to target with a laser or other external energy 318.

[0222] Figure 4B The illustration shows that the expandable component 406 can be an expandable microsphere that includes an expandable thermoplastic shell 408 and a blowing agent 410 contained within the expandable thermoplastic shell 408. The microspheres can be configured to expand so that the diameter 412 of at least one of the microspheres can increase by about 2X of the original diameter. In other embodiments, the microspheres can be configured to expand so that the diameter 412 of at least one of the microspheres can increase by about 4X or 4 times the original diameter. In still other embodiments, the microspheres can be configured to expand so that the diameter 412 of at least one of the microspheres can increase between about 2X and about 4X (or about 3.5X) the original diameter. For example, the microspheres can initially have a diameter 412 of about 12 μm. In response to external energy applied to or directed toward the composite material 400 or in response to energy transferred or transmitted to the microspheres, the diameter 412 of the microspheres can increase to about 40 μm.

[0223] The volume of at least one of the microspheres can be configured to expand from about ten times (10X) to about fifty times (50X) in response to external energy applied to or directed toward the composite material 400 or in response to energy transferred or transmitted to the microsphere.

[0224] In some embodiments, the foaming agent 410 can be an expandable fluid, such as an expandable gas. More specifically, the foaming agent 410 can be a branched hydrocarbon. For example, the foaming agent 410 can be isopentane. In other embodiments, the foaming agent 410 can be or include cyclopentane, pentane, or a mixture of cyclopentane, pentane, and isopentane.

[0225] The expandable components 406 can contain different amounts of the blowing agent 410. For example, some expandable components 406 can contain more or a greater amount of blowing agent (e.g., more expanding gas) to allow such expandable components 406 to expand more, thereby resulting in greater expansion of the composite material 400 including such expandable components 406.

[0226] Figure 4B It is illustrated that each of the expandable components 406 may include a thermoplastic shell 408 . Figure 4B It is also illustrated that the thickness of the thermoplastic shell 408 can change as the size of the expandable component 406 increases. More specifically, the thickness of the thermoplastic shell 408 can decrease as the size of the expandable component 406 increases. For example, when the expandable component 406 is an expandable microsphere, the thickness of the thermoplastic shell 408 (i.e., its thickness in the radial direction) can decrease as the diameter 412 of the expandable microsphere increases.

[0227] For example, as previously described, at least one of the expandable microspheres may initially have a diameter 412 of approximately 12 μm. In this embodiment, the thermoplastic shell 408 of the expandable microsphere may have a shell thickness of approximately 2.0 μm. In response to external energy applied to or directed toward the composite material 400 or in response to energy transferred or transmitted to the microsphere, the diameter 412 of the microsphere may increase to approximately 40 μm (and expand in volume by between approximately 10X and 50X) and the shell thickness of the microsphere may decrease to approximately 0.1 μm.

[0228] Although Figure 4A and Figure 4B The expandable member 406 is illustrated as a sphere or microsphere, but the present disclosure contemplates that the expandable member 406 can be shaped substantially as an oval, ellipsoid, cuboid, or other polyhedron, or combinations thereof.

[0229] In some embodiments, the thermoplastic shell 408 can be partially made of a nitrile or acrylonitrile copolymer. For example, the thermoplastic shell 408 can be partially made of acrylonitrile, styrene, butadiene, methyl acrylate, or a combination thereof.

[0230] As previously mentioned, the expandable component 406 may comprise from about 8.0% to about 12% by weight of the final formulation of the composite material 400. The expandable component 406 may comprise about 10% by weight of the final formulation of the composite material 400.

[0231] The expandable components 406 can be dispersed or otherwise distributed within the composite substrate 402 that constitutes the body of the composite material 400. The composite substrate 402 can serve as a matrix for holding or supporting the expandable components 406. The composite material 400 can expand in response to the expansion of the expandable components 406 (e.g., thermoplastic microspheres). For example, the volume of the composite material 400 can increase in response to the expansion of the expandable components 406.

[0232] Composite material 400 also includes an energy absorbing component 404. In some embodiments, energy absorbing component 404 can be an energy absorbing colorant.

[0233] In certain embodiments, the energy absorbing colorant can be an energy absorbing dye. For example, the energy absorbing dye can be an azo dye. In certain embodiments, the azo dye can be a red azo dye, such as disperse red 1 dye. In other embodiments, the azo dye can be an orange azo dye, such as disperse orange dye (for example, disperse orange 1), a yellow azo dye, such as disperse yellow dye (for example, disperse yellow 1), a blue azo dye, such as disperse blue dye (for example, disperse blue 1), or a combination thereof.

[0234] In other embodiments, the energy absorbing colorant can be or include a pigment. For example, the energy absorbing colorant can be or include graphitized carbon black as a pigment.

[0235] Similar to expandable component 406, energy absorbing element 404 can be dispersed or otherwise distributed within composite substrate 402 that comprises the body of composite material 400. Composite substrate 402 can serve as a matrix for holding or supporting expandable component 406 and energy absorbing element 404.

[0236] As previously described, the energy absorbing component 404 may comprise between about 0.025% and about 1.0% (or more specifically, between about 0.045% and about 0.45%) by weight of the final formulation of the composite material 400. For example, when the energy absorbing component 404 is a dye (e.g., an azo dye such as Disperse Red 1), the energy absorbing component 404 may comprise between about 0.45% and about 1.0% by weight of the final formulation of the composite material 400. When the energy absorbing component 404 is graphitized carbon black or another type of pigment, the energy absorbing component 404 may comprise between about 0.025% and about 0.045% by weight of the final formulation of the composite material 400.

[0237] Energy absorbing component 404 (e.g., azo dye, graphitized carbon black, or a combination thereof) can absorb or capture external energy applied to or directed toward composite material 400. Energy absorbing component 404 can absorb or capture external energy and then convert or transfer the energy into thermal energy or heat to expandable component 406.

[0238] When thermal energy is transferred or transmitted to the expandable component 406, the thermoplastic shell 408 can soften and begin to flow. The thermoplastic shell 408 of the expandable component 406 can then begin to thin or reduce in thickness in response to the thermal energy transferred or transmitted to the expandable component 406. As the thermoplastic shell 408 begins to soften and reduce in thickness, the blowing agent 410 within the expandable component 406 can expand. The blowing agent 410 can also expand in response to the thermal energy or heat transferred or transmitted to the expandable component 406. The expansion of the blowing agent 410 can cause the expandable component 406 (e.g., thermoplastic microspheres) to expand or increase in volume. This ultimately causes the composite material 400 to expand or increase in volume.

[0239] The composite material 400 can expand or increase in size in an isotropic manner, such that the composite material 400 expands in all directions. This isotropic expansion can be exploited to produce expansion or material displacement in a specific direction by placing or positioning the composite material 400 at specific locations within the peripheral fluid chamber 108 along the haptic(s) 104 or optic portion 102 of the accommodating IOL 100.

[0240] As will be discussed in more detail in the following sections, in some embodiments, the external energy can be light energy, and the energy absorbing component 404 can absorb or capture the light energy directed toward the composite material 400 and convert or transfer the light energy into thermal energy or heat to the expandable component 406. The blowing agent 410 within the expandable component 406 can expand or become energized in response to the thermal energy or heat. In response to this light energy directed toward the composite material 400, the expandable component 406, and ultimately the composite material 400, can expand or increase in volume.

[0241] The shape change (e.g., volume increase) experienced by the expandable component 406 can be a permanent or substantially permanent change. A permanent or substantially permanent change can mean that after the shape change (e.g., after the volume increase) occurs, the expandable component 406 does not substantially return to its original shape or size. Thus, any change in the size or volume of the composite material 400 caused by a change in the size or volume of the expandable component 406 is also permanent or substantially permanent. As will be discussed in more detail in the following sections, this means that any structural change to the accommodating IOL 100 due to external energy or stimulation applied or otherwise directed to the composite material 400 embedded or integrated within the accommodating IOL 100 can be permanent or substantially permanent.

[0242] When external energy is no longer directed or applied to composite material 400, thermoplastic shell 408 of expandable component 406 can harden again. For example, when the temperature within the vicinity of expandable component 406 drops below a certain threshold, thermoplastic shell 408 can harden again. For example, when light energy is no longer directed to composite material 400, thermoplastic shell 408 of expandable microspheres can harden. After thermoplastic shell 408 hardens, expandable components 406 are locked into their new size and expanded configuration.

[0243] When the energy absorbing component 404 is an energy absorbing colorant, such as a dye or graphitized carbon, the color of at least a portion of the composite material 400 can take on the color of the energy absorbing colorant. For example, when the energy absorbing component 404 is an azo dye, such as Disperse Red 1 having a red color, at least a portion of the composite material 400 including the energy absorbing component 404 can be colored red. Additionally, when the energy absorbing component 404 is graphitized carbon having a black color, at least a portion of the composite material 400 including the energy absorbing component 404 can be colored black. While two colors (e.g., red and black) are mentioned in the present disclosure, the present disclosure contemplates and one of ordinary skill in the art will appreciate that other types of energy absorbing colorants, such as yellow, orange, or blue dyes or materials that absorb energy, can also be used.

[0244] When at least a portion of accommodating IOL 100 is made from composite material 400 containing an energy-absorbing colorant, the color of the energy-absorbing colorant can be visually perceptible to a clinician or other medical professional. When accommodating IOL 100 is implanted in a patient's eye, the color of the energy-absorbing colorant can be visually perceptible to the clinician or other medical professional. For example, composite material 400 can include Disperse Red 1 as the energy-absorbing colorant. In this example, when accommodating IOL 100 is implanted in a patient's eye, at least a portion of accommodating IOL 100 can appear red to the clinician or other medical professional.

[0245] The color of the energy-absorbing colorant can allow a clinician or another medical professional to detect or determine the location or position of composite material 400 within accommodating IOL 100. The color of the energy-absorbing colorant can also allow a clinician or another medical professional to determine where to direct external energy or stimulation to accommodate accommodating IOL 100.

[0246] One technical problem faced by the applicants is how to integrate a composite material into the peripheral portion (e.g., the haptics) of an accommodating IOL so that the composite material will adhere to the material used to make the rest of the accommodating IOL and remain substantially fixed at certain locations within the peripheral portion. One solution discovered by the applicants and disclosed herein is the unique composition of composite material 400, which incorporates the same copolymer blend used to make the rest of the lens. By designing the accommodating IOL in this manner, composite material 400 can be compatible with the rest of the material used to construct the peripheral portion and remain substantially fixed at its locations without migrating or shifting.

[0247] Another technical problem faced by the applicant is how to ensure that any adjustments made to an accommodative IOL persist for a long time after the adjustment procedure. One solution discovered by the applicant and disclosed herein is to cause expansion of a composite material made in part of expandable microspheres, which expandable microspheres include a blowing agent contained within a thermoplastic shell. The thermoplastic shell can soften (and the thickness of the thermoplastic shell can be reduced) in response to external energy directed or applied to the composite material (which can cause heat or thermal energy to be transferred or transmitted to the expandable microspheres). The blowing agent within the thermoplastic shell can expand as the thermoplastic shell softens. The expansion of the blowing agent can cause the microspheres to expand, which in turn can cause the composite substrate serving as the body of the composite material to expand. The expandable microspheres can maintain their new enlarged or expanded configuration even after external energy is no longer applied to the composite material.

[0248] Furthermore, the energy-absorbing component of composite material 400 can capture or absorb relatively harmless external energy or stimulus directed toward the composite material and convert or transfer the external energy into thermal energy, which can then cause the thermoplastic microspheres to expand. By designing accommodating IOL 100 in this manner, bursts of relatively harmless energy or stimulus (e.g., light energy) can be used to induce a sustained change in the shape or size of at least a portion of accommodating IOL 100. Such a sustained change in the shape or size of accommodating IOL 100 can have a sustained effect on the optical parameters of the lens, including, for example, its base power.

[0249] Figure 5 A top plan view of another embodiment of an accommodative static focus IOL 100 is shown with a portion of the front of the accommodative IOL 100 removed to better illustrate the components within the IOL. Figure 5As shown in FIG, first peripheral component 138 can be made of a first composite material including a first energy-absorbing component having a first color, and second peripheral component 140 can be made of a second composite material including a second energy-absorbing component having a second color different from the first color. This color difference can be visually perceptible to a clinician or another medical professional and can allow the clinician or other medical professional to visually distinguish the two types of peripheral components 136.

[0250] For example, the first energy absorbing component can be an energy absorbing dye. As a more specific example, the energy absorbing dye can be an azo dye, such as a red azo dye (e.g., Disperse Red 1 dye). In this example, the second energy absorbing component can be another energy absorbing dye, such as a yellow azo dye or another light-colored dye.

[0251] In other examples, the first energy absorbing component can be or include a pigment, such as graphitized carbon black (which exhibits a black color). In these embodiments, the second energy absorbing component can be an energy absorbing dye (eg, a red azo dye).

[0252] In further examples, the second energy absorbing component can be or include a pigment, such as graphitized carbon black (which exhibits a black color). In these embodiments, the first energy absorbing component can be an energy absorbing dye (eg, a red azo dye).

[0253] In other embodiments, the first composite material and the second composite material may be made in part from the same energy absorbing component or colorant, but contain different amounts or weight percentages of such component or colorant.

[0254] In some embodiments, a first peripheral component 138 made of a first composite material (and having a first color) can expand or change shape in response to a first type of external energy directed toward the first composite material (e.g., light energy between 520nm and 540nm), and a second peripheral component 140 made of a second composite material (and having a second color different from the first color) can expand in response to a second type of external energy directed toward the second composite material (e.g., light energy between 600nm and 650nm).

[0255] By designing accommodating IOL 100 in this manner, a clinician or other medical professional can use the different colors of the composite material as guides or markers to direct external energy or stimulation to different target locations along peripheral portion 103. Additionally, the differently colored composite materials can also serve as indicators or visual cues indicating where to direct external energy or stimulation to induce certain changes in the base power of optic portion 102.

[0256] For example, the accommodating IOL 100 can be configured such that the base power of the accommodating IOL 100 can be adjusted in a first manner (e.g., the base power can be increased) by directing or otherwise applying external energy to a first peripheral component 138 made of a first composite material (having a first color). The base power of the accommodating IOL 100 can also be adjusted in a second manner (e.g., the base power can be decreased) by directing or otherwise applying additional bursts or pulses of external energy to a second peripheral component 140 made of a second composite material (having a second color different from the first color).

[0257] Figure 6 A top plan view of another embodiment of an accommodating IOL 100 is illustrated in which the optic 102 includes a beam-splitting lens surface profile 600. A peripheral portion 103 of the accommodating IOL 100 is shown in phantom to emphasize the optic 102.

[0258] One technical problem faced by the applicants is how to design a liquid-filled IOL that can be used by patients seeking different types of vision support (e.g., near vision, intermediate vision, distance vision, etc.). One solution discovered by the applicants is the accommodating IOL disclosed herein, in which different lens surface profiles can be defined on the outer optical surface of the optic portion (e.g., the anterior optical surface), both rotationally symmetric and toric profiles to correct astigmatism, thereby allowing the same accommodating IOL structure to be adapted as an accommodating monofocal IOL, an accommodating bifocal IOL, an accommodating trifocal IOL, or an accommodating EDOF IOL in both toric and non-toric shapes.

[0259] like Figure 6 As shown in FIG, the optical portion 102 of the accommodating IOL 100 may include a beam splitting lens surface profile 600 defined on the lens surface of the optical portion 102. In some embodiments, the beam splitting lens surface profile 600 may include a central diffractive region or structure that includes a plurality of diffraction zones or diffraction orders. In these and other embodiments, the widths of the diffraction zones may decrease in a radially outward manner such that the zone widths at the periphery of the lens are less than the zone widths near the central portion of the lens.

[0260] The beam splitter lens surface profile 600 can separate light into multiple faci or focal points. In these embodiments, the accommodating IOL 100 can be considered an accommodating multifocal IOL or a non-modulating fluid-accommodating multifocal IOL. Even though the beam splitter lens surface profile 600 can separate light into multiple faci or focal points, each such focal point is static and the fluid-accommodating multifocal IOL is considered non-modulating.

[0261] In some embodiments, the beam-splitting lens surface profile 600 can be configured to split light into two foci (e.g., thereby allowing near vision and distance vision). In these embodiments, the accommodating IOL 100 can be considered an accommodating bifocal IOL or a non-modulating fluid-accommodating bifocal IOL. In these embodiments, even though the beam-splitting lens surface profile 600 can split light into two foci, each such focus is static and the fluid-accommodating bifocal IOL is considered non-modulating.

[0262] The beam splitting lens surface profile 600 can also be configured to split light into three focal points (e.g., thereby allowing near vision, intermediate vision, and distance vision). In these embodiments, the accommodating IOL 100 can be considered an accommodating trifocal IOL or a non-modulating fluid accommodating trifocal IOL.

[0263] exist Figure 6 In other embodiments not shown, the optic portion 102 of the accommodating IOL 100 can have a uniformly curved (e.g., spherical) lens surface or an aspherical lens surface that provides focusing power for a single distance. In these embodiments, the accommodating IOL 100 can be considered an accommodating monofocal IOL or a non-modulating fluid-accommodating monofocal IOL.

[0264] exist Figure 6 In additional embodiments not shown, the optic portion 102 of the accommodating IOL 100 can have a lens surface profile or pattern configured to provide an extended depth of focus or a single elongated focus. In these embodiments, the accommodating IOL 100 can be considered an accommodating extended depth of focus (EDOF) IOL or a non-modulating fluid-accommodating EDOF IOL.

[0265] The present disclosure contemplates that the unique peripheral portion 103 disclosed herein can be compatible with optical portions 102 comprising various lens surface profiles. Thus, directing external energy (e.g., laser light) to the peripheral component(s) 136 made of composite material 400 in the peripheral portion 103 can adjust the focusing power(s) or focal length(s) provided by such lens surface profiles.

[0266] Any of the accommodating monofocal IOL, the accommodating multifocal IOL, and the accommodating EDOF IOL may include a toric lens profile.

[0267] Figure 7is one embodiment of a method 700 for postoperatively adjusting an IOL 100. The method 700 may include, in operation 702, increasing the base power of the IOL 100 by directing external energy 318 toward a composite material 400 configured as a space filler 310 positioned within a peripheral fluid chamber 108 defined within a peripheral portion 103 of the IOL 100. The method 700 may also include, in operation 704, decreasing the base power by directing external energy 318 toward another instance of the composite material 400 configured as a chamber expander 312 positioned within the peripheral fluid chamber 108.

[0268] Figure 8 8 is another embodiment of a method 800 for postoperatively adjusting an IOL 100. The method 800 may include, in operation 802, adjusting the base power of the IOL 100 by directing a pulse of external energy 318 to a first peripheral component 138 within a peripheral fluid chamber 108 defined within a peripheral portion 103 of the IOL 100. The method 800 may also include, in operation 804, further adjusting the base power by directing an additional pulse of external energy 318 to a second peripheral component 140 within the same peripheral fluid chamber 108.

[0269] For example, the first peripheral component 138 can be a space filler 310, and directing external energy 318 toward the space filler 310 can cause the space filler 310 to expand and reduce the volume of the peripheral fluid chamber 108 and displace fluid from the peripheral fluid chamber 108 into the optical fluid chamber 106 (thereby increasing the base power of the optical portion 102). The second peripheral component 140 can be a chamber expander 312, and directing external energy 318 toward the chamber expander 312 can cause the chamber expander 312 to expand and increase the volume of the peripheral fluid chamber 108 and draw fluid from the optical fluid chamber 106 into the peripheral fluid chamber 108 (thereby reducing the base power of the optical portion 102).

[0270] Alternatively, the external energy 318 may first be directed to the chamber expander 312 to reduce the base power of the optical portion 102 , and then the external energy 318 may subsequently be directed to the space filler 310 to increase the base power of the optical portion 102 .

[0271] Figure 99 is yet another embodiment of a method 900 for postoperatively adjusting an IOL 100. The method 900 may include, in operation 902, adjusting a base power of the IOL 100 by directing a pulse of external energy to a first peripheral component 138 within a first (e.g., a first haptic fluid chamber) of the peripheral fluid chambers 108 defined within the peripheral portion 103 of the IOL 100. The method 900 may also include, in operation 904, adjusting the base power of the IOL 100 by directing an additional pulse of external energy to a second peripheral component 140 or another instance of the first peripheral component 138 within a second (e.g., a second haptic fluid chamber) of the peripheral chambers 108 of the peripheral portion 103 of the IOL 100.

[0272] The first peripheral component 138 can be a space filler 310, and directing external energy 318 toward the space filler 310 can cause the space filler 310 to expand and reduce the volume of the first peripheral fluid chamber and displace fluid from the first peripheral fluid chamber into the optical fluid chamber 106 (thereby increasing the base power of the optical portion 102). The second peripheral component 140 can be a chamber expander 312, and directing external energy 318 toward the chamber expander 312 can cause the chamber expander 312 to expand and increase the volume of the second peripheral fluid chamber and draw fluid from the optical fluid chamber 106 into the second peripheral fluid chamber (thereby reducing the base power of the optical portion 102).

[0273] In some embodiments, pulses of external energy 318 can be directed to the chamber expander 312 within the first peripheral fluid chamber to reduce the base focal length of the optical portion 102, and additional pulses of external energy 318 can be directed to the space filler 310 within the second peripheral fluid chamber to increase the base focal length of the optical portion 102.

[0274] Figure 10 1 is another embodiment of a method 1000 for postoperatively adjusting an IOL 100. The method 1000 may include, at operation 1002, adjusting the base power of the IOL 100 in a first direction by directing external energy 318 toward a first composite material. The first composite material may include a first energy-absorbing component having a first color. The method 1000 may also include, at operation 1004, adjusting the base power of the IOL 100 in a second direction by directing external energy toward a second composite material. The second composite material may include a second energy-absorbing component having a second color different from the first color.

[0275] For example, a first composite material can be formed into a space filler 310. In this example, the first energy absorbing component of the first composite material can be an azo dye having a first color (e.g., red). Additionally, in this example, a second composite material can be formed into a chamber expander 312, and the second energy absorbing component of the second composite material can be an energy absorbing pigment, such as graphitized carbon black, or an azo dye having a second color (e.g., blue or yellow) that is different from the first color.

[0276] In other embodiments, the first composite material can be formed into a chamber expander 312, and the first energy-absorbing component of the first composite material can be an azo dye having a first color (e.g., red). In these embodiments, the second composite material can be formed into a space filler 310, and the second energy-absorbing component of the second composite material can be an energy-absorbing pigment, such as graphitized carbon black, or an azo dye having a second color (e.g., blue or yellow) that is different from the first color.

[0277] In one or more methods disclosed herein, adjusting the base power of the IOL 100 may include adjusting the base power of the optic portion 102 by between approximately ±0.05D and approximately ±0.50D by directing pulses of external energy 318 toward the composite material 400 to expand the composite material 400. For example, adjusting the base power of the IOL 100 may include adjusting the base power of the optic portion 102 by approximately ±0.10D by directing pulses of external energy 318 toward the composite material 400 to expand the composite material 400.

[0278] For example, the base power of the optical portion 102 can be adjusted by between about ±0.05D and about ±0.50D in response to fluid displacement or exchange between the optical fluid chamber 106 and one of the peripheral fluid chambers 108 due to a volume change of the peripheral fluid chamber 108, which results from expansion of the peripheral member 136 caused by the pulse of external energy 318 directed toward the peripheral member 136. As a more specific example, the base power of the optical portion 102 can be increased by between about +0.05D and about +0.50D in response to fluid entering the optical fluid chamber 106 from one of the peripheral fluid chambers 108 due to a volume decrease of the peripheral fluid chamber 108, which results from expansion of the first peripheral member 138 caused by the pulse of external energy 318 directed toward the first peripheral member 138. As another more specific example, the base focal length of the optical portion 102 can be reduced by between about -0.05D and about -0.50D in response to fluid leaving the optical fluid chamber 106 and entering one of the peripheral fluid chambers 108 due to an increase in the volume of the peripheral fluid chamber 108 due to expansion of the second peripheral component 140 caused by the pulse of external energy 318 directed toward the second peripheral component 140.

[0279] In one or more methods disclosed herein, adjusting the base power of the IOL 100 can include adjusting the base power of the IOL 100 by directing pulses of external energy 318 to the plurality of peripheral components 136 to a total of between approximately ±1.0D and approximately ±2.0D.

[0280] In one or more methods disclosed herein, directing external energy 318 toward composite material can further include directing light energy toward composite material 400. For example, directing external energy 318 toward composite material 400 can further include directing a laser toward composite material 400. As a more specific example, directing external energy 318 toward composite material 400 can further include directing a green laser toward composite material 400.

[0281] In one or more methods disclosed herein, directing external energy 318 toward composite material 400 can include directing a laser having a wavelength between about 488 nm and about 650 nm toward composite material 400. In other embodiments, directing external energy 318 toward composite material 400 can further include directing a laser having a wavelength between about 946 nm and about 1120 nm toward composite material 400.

[0282] One disadvantage of currently available tunable IOLs, such as dichroic lenses, is that the tuning procedure takes time to take effect, may require multiple visits to the clinician's office, and the clinician must often purchase expensive new equipment to perform such tuning procedures. One advantage of the static focus adjustable IOL 100 disclosed herein is that such static focus adjustable IOL 100 allows for post-operative refractive error correction in seconds rather than hours. This allows the patient to provide almost immediate feedback about their refractive error correction. Furthermore, the IOL 100 disclosed herein can be tuned using commercially available lasers commonly found in most clinicians' offices (e.g., 532 nm photocoagulator lasers). Furthermore, the patient does not need to wear UV blocking glasses during the healing period, and refractive error correction can be performed months or even years after the initial implantation procedure.

[0283] Disclosed herein is an intraocular lens comprising: an optical portion; a peripheral portion coupled to the optical portion; wherein the peripheral portion comprises a composite material comprising an energy absorbing component and a plurality of expandable components, wherein a base power of the optical portion is configured to change in response to external energy directed toward the composite material, and wherein the base power of the optical portion is configured to be unresponsive to forces applied to the peripheral portion by the capsular bag when the intraocular lens is implanted within the capsular bag.

[0284] The intraocular lens as disclosed herein, wherein the expandable component is an expandable microsphere, and wherein each of the expandable microspheres comprises a blowing agent contained within a thermoplastic shell.

[0285] An intraocular lens as disclosed herein, wherein the thickness of the thermoplastic shell is configured to change in response to external energy directed toward the composite material.

[0286] An intraocular lens as disclosed herein, wherein the blowing agent is a branched hydrocarbon.

[0287] An intraocular lens as disclosed herein, wherein the branched chain hydrocarbon is isopentane.

[0288] An intraocular lens as disclosed herein, wherein the thermoplastic shell is made in part from an acrylonitrile copolymer.

[0289] An intraocular lens as disclosed herein, wherein the diameter of at least one of the expandable microspheres is configured to increase by about 2X to about 4X in response to external energy directed to the composite material.

[0290] An intraocular lens as disclosed herein, wherein the volume of at least one of the expandable components is configured to expand approximately 10X to 50X in response to external energy directed toward the composite material.

[0291] An intraocular lens as disclosed herein, wherein the expandable component comprises from about 5% to about 15% by weight of the composite material.

[0292] An intraocular lens as disclosed herein, wherein the expandable component comprises about 10% by weight of the composite material.

[0293] An intraocular lens as disclosed herein, wherein the energy absorbing component is an energy absorbing colorant.

[0294] An intraocular lens as disclosed herein, wherein the color of the energy absorbing colorant is visually perceptible when the intraocular lens is implanted in the eye.

[0295] An intraocular lens as disclosed herein, wherein the energy absorbing colorant is a dye.

[0296] An intraocular lens as disclosed herein, wherein the dye is an azo dye.

[0297] An intraocular lens as disclosed herein, wherein the dye is Disperse Red 1 dye.

[0298] An intraocular lens as disclosed herein, wherein the energy absorbing colorant is an energy absorbing pigment.

[0299] An intraocular lens as disclosed herein, wherein the energy absorbing pigment is graphitized carbon black.

[0300] An intraocular lens as disclosed herein, wherein the energy absorbing component comprises from about 0.025% to about 1.00% by weight of the composite material.

[0301] An intraocular lens as disclosed herein, wherein the peripheral portion is made in part of a cross-linked copolymer comprising a copolymer blend, and wherein the composite material is made in part of a copolymer blend.

[0302] An intraocular lens as disclosed herein, wherein the composite material cures to a cross-linked copolymer at a location within the peripheral portion, and wherein the composite material remains substantially fixed at that location.

[0303] An intraocular lens as disclosed herein, wherein the base power of the optical portion is configured to vary between about ±0.05D and about ±0.5D in response to a pulse of external energy directed to the composite material.

[0304] An intraocular lens as disclosed herein, wherein the base power of the optic portion is configured to change by approximately 0.1 D in response to a pulse of external energy directed to the composite material.

[0305] An intraocular lens as disclosed herein, wherein the base power of the optical portion is configured to vary between approximately ±1.0D and approximately ±2.0D in total.

[0306] An intraocular lens as disclosed herein, wherein the change in base power is a continuous change.

[0307] An intraocular lens as disclosed herein, wherein the external energy is light energy.

[0308] An intraocular lens as disclosed herein, wherein the optical energy is laser light.

[0309] An intraocular lens as disclosed herein, wherein the laser has a wavelength between about 488 nm and about 650 nm.

[0310] An intraocular lens as disclosed herein, wherein the laser is a green laser.

[0311] An intraocular lens as disclosed herein, wherein the green laser has a wavelength of approximately 532 nm.

[0312] An intraocular lens as disclosed herein, wherein the laser has a wavelength between about 946 nm and about 1120 nm.

[0313] An intraocular lens as disclosed herein, wherein the laser has a wavelength of approximately 1030 nm.

[0314] An intraocular lens as disclosed herein, wherein the laser has a wavelength between approximately 1030 nm and 1064 nm.

[0315] An intraocular lens as disclosed herein, wherein the laser light is emitted by a femtosecond laser.

[0316] An intraocular lens as disclosed herein, wherein the laser light is emitted by a neodymium-doped yttrium aluminum garnet (Nd:YAG) laser.

[0317] An intraocular lens as disclosed herein, wherein the energy absorbing component is configured to transfer thermal energy to the plurality of expandable components in response to external energy directed toward the composite material.

[0318] As disclosed herein, an intraocular lens wherein the composite material is formed into discrete peripheral components such that directing external energy to one discrete peripheral component causes a change in the base power of the optical portion, and directing external energy to another discrete peripheral component also causes a change in the base power of the optical portion.

[0319] An intraocular lens as disclosed herein, wherein the peripheral portion comprises 20 to 40 peripheral components.

[0320] An intraocular lens as disclosed herein, wherein the optical portion comprises an optical fluid chamber, and the peripheral portion comprises at least one peripheral fluid chamber in fluid communication with the optical fluid chamber.

[0321] An intraocular lens as disclosed herein, wherein the peripheral fluid chamber is curved and the peripheral fluid chamber follows the curvature of the optic portion.

[0322] An intraocular lens as disclosed herein, wherein the peripheral fluid chamber has a chamber height, and wherein the chamber height is between about 0.1 mm and about 0.3 mm.

[0323] As disclosed herein, an intraocular lens, wherein the composite material is configured as a chamber expander, wherein the chamber expander is configured to expand in response to external energy directed toward the chamber expander, and wherein expansion of the chamber expander increases the volume of the peripheral fluid chamber.

[0324] An intraocular lens as disclosed herein, wherein the base power of the optical portion is configured to decrease in response to external energy directed to the chamber expander.

[0325] An intraocular lens as disclosed herein, wherein the chamber expander is configured as an expandable column extending from the anterior chamber wall to the posterior chamber wall.

[0326] An intraocular lens as disclosed herein, wherein the composite material is configured as a space filler, wherein the space filler is configured to expand in response to external energy directed toward the space filler, and wherein expansion of the space filler reduces the volume of the peripheral fluid chamber.

[0327] An intraocular lens as disclosed herein, wherein the space filler is configured as a pad extending from the anterior chamber wall or the posterior chamber wall.

[0328] An intraocular lens as disclosed herein, wherein the base power of the optical portion is configured to increase in response to external energy directed toward the space filler.

[0329] An intraocular lens as disclosed herein, wherein the base power is configured to change in response to fluid displacement between the optical fluid chamber and the peripheral fluid chamber due to external energy directed toward the composite material.

[0330] An intraocular lens as disclosed herein, wherein the peripheral portion is configured as at least one haptic, wherein a peripheral fluid chamber is defined within the haptic, wherein the peripheral fluid chamber only partially extends into the haptic.

[0331] An intraocular lens as disclosed herein, wherein the at least one haptic comprises a haptic proximal portion and a haptic distal portion, wherein the haptic distal portion comprises a haptic distal arm that is not attached to the optic except via the haptic proximal portion.

[0332] An intraocular lens as disclosed herein, wherein the haptic distal arm comprises a kink or bend.

[0333] An intraocular lens as disclosed herein, wherein the peripheral fluid chamber is defined within the proximal haptic portion, wherein the chamber segment of the proximal haptic portion is not connected to the optic portion.

[0334] An intraocular lens as disclosed herein, wherein the at least one haptic is connected to the optic portion at a proximal end of the haptic and at a distal connection portion located distal to the chamber segment.

[0335] An intraocular lens as disclosed herein, wherein the proximal end of the haptic is connected to and extends from a side surface of the optic portion, wherein the side surface has a side height, and wherein the side height is approximately 0.65 mm.

[0336] An intraocular lens as disclosed herein, wherein the peripheral portion is configured as a first haptic comprising a first haptic fluid chamber and a second haptic comprising a second haptic fluid chamber, and wherein the optical portion comprises an optical fluid chamber.

[0337] An intraocular lens as disclosed herein, wherein a first tactile fluid chamber is in fluid communication with an optical fluid chamber via a first fluid channel, wherein a second tactile fluid chamber is in fluid communication with the optical fluid chamber via a second fluid channel, and wherein the first fluid channel is positioned radially opposite to the second fluid channel.

[0338] An intraocular lens as disclosed herein, wherein the optical fluid chamber, the first tactile fluid chamber, and the second tactile fluid chamber comprise a total fluid volume of between about 10 μL and about 20 μL of fluid.

[0339] An intraocular lens as disclosed herein, wherein each of the first tactile fluid chamber and the second tactile fluid chamber comprises approximately 0.5 μL of fluid.

[0340] An intraocular lens as disclosed herein, wherein approximately 15 nL of fluid is exchanged between the first and second haptic fluid chambers and the optical fluid chamber in response to expansion of the composite material.

[0341] An intraocular lens as disclosed herein, wherein the fluid is silicone oil.

[0342] An intraocular lens as disclosed herein, wherein the peripheral portion comprises a first composite material and a second composite material, wherein the first composite material comprises a first energy absorbing component and the second composite material comprises a second energy absorbing component, wherein a color of the first energy absorbing component is different from a color of the second energy absorbing component.

[0343] The present invention also discloses an intraocular lens comprising: an optical portion; and a peripheral portion coupled to the optical portion, wherein the peripheral portion comprises a first peripheral component and a second peripheral component, wherein the first peripheral component is made of a composite material comprising an energy-absorbing component and a plurality of expandable components, wherein the second peripheral component is made of a composite material comprising an energy-absorbing component and a plurality of expandable components, wherein the base focal length of the optical portion is configured to increase in response to external energy directed to the first peripheral component, wherein the base focal length of the optical portion is configured to decrease in response to external energy directed to the second peripheral component, and wherein the base focal length of the optical portion is configured to be unresponsive to forces applied to the peripheral portion by the capsular bag when the intraocular lens is implanted in the capsular bag.

[0344] An intraocular lens as disclosed herein, wherein the optical portion comprises an optical fluid chamber and the peripheral portion comprises at least one peripheral fluid chamber in fluid communication with the optical fluid chamber.

[0345] An intraocular lens as disclosed herein, wherein the base power is configured to change in response to fluid displacement between the optical fluid chamber and the peripheral fluid chamber due to external energy directed to the first peripheral component or the second peripheral component.

[0346] An intraocular lens as disclosed herein, wherein the first peripheral component is configured as a space filler, wherein the space filler is configured to expand in response to external energy directed toward the space filler, and wherein expansion of the space filler reduces the volume of the peripheral fluid chamber.

[0347] An intraocular lens as disclosed herein, wherein the space filler is configured as an expandable pad extending from the anterior chamber wall or the posterior chamber wall.

[0348] An intraocular lens as disclosed herein, wherein the second peripheral component is configured as a chamber expander, wherein the chamber expander is configured to expand in response to external energy directed toward the chamber expander, and wherein expansion of the chamber expander increases the volume of the peripheral fluid chamber.

[0349] An intraocular lens as disclosed herein, wherein the chamber expander is configured as an expandable column extending from the anterior chamber wall to the posterior chamber wall.

[0350] An intraocular lens as disclosed herein, wherein the first peripheral component and the second peripheral component are located within the same peripheral fluid chamber.

[0351] An intraocular lens as disclosed herein, wherein the second peripheral component is positioned distally from the first peripheral component within the same peripheral fluid chamber.

[0352] An intraocular lens as disclosed herein, wherein a first peripheral component is positioned proximate to a second peripheral component within the same peripheral fluid chamber, and wherein the first peripheral component is positioned closer to a fluid channel connecting the optical fluid chamber to the peripheral fluid chamber than the second peripheral component.

[0353] As disclosed herein, an intraocular lens, wherein the first peripheral component and the second peripheral component are configured as discrete peripheral components, such that directing external energy to one discrete peripheral component causes a change in the base power of the optical portion, and directing external energy to the other discrete peripheral component also causes a change in the base power of the optical portion.

[0354] An intraocular lens as disclosed herein, wherein a peripheral fluid chamber comprises at least ten first peripheral components.

[0355] An intraocular lens as disclosed herein, wherein one peripheral fluid chamber comprises at least ten second peripheral components.

[0356] The intraocular lens as disclosed herein, wherein the expandable component is an expandable microsphere, and wherein each of the expandable microspheres comprises a blowing agent contained within a thermoplastic shell.

[0357] An intraocular lens as disclosed herein, wherein the energy absorbing component is an energy absorbing colorant.

[0358] An intraocular lens as disclosed herein, wherein the base power of the optical portion is configured to vary between about ±0.05D and about ±0.5D in response to a pulse of external energy directed to the first peripheral component or the second peripheral component.

[0359] An intraocular lens as disclosed herein, wherein the base power of the optical portion is configured to change by approximately 0.1 D in response to a pulse of external energy directed toward the first peripheral component or the second peripheral component.

[0360] An intraocular lens as disclosed herein, wherein the base power of the optical portion is configured to vary between approximately ±1.0D and approximately ±2.0D in total.

[0361] An intraocular lens as disclosed herein, wherein the external energy is light energy.

[0362] An intraocular lens as disclosed herein, wherein the optical energy is laser light.

[0363] Also disclosed herein is a method for postoperatively adjusting an intraocular lens, comprising: adjusting a base power of the intraocular lens by directing external energy to a composite material within a peripheral portion of the intraocular lens, wherein the peripheral portion is coupled to an optic portion disposed radially inward of the peripheral portion, wherein the composite material includes an energy absorbing component and a plurality of expandable components, and wherein the base power of the intraocular lens is configured to be unresponsive to forces applied to the peripheral portion by the capsular bag when the intraocular lens is implanted within the capsular bag.

[0364] A method as disclosed herein, wherein the optical portion includes an optical fluid chamber and the peripheral portion includes at least one peripheral fluid chamber in fluid communication with the optical fluid chamber, and wherein the base power of the intraocular lens changes in response to fluid displacement between the optical fluid chamber and the peripheral fluid chamber due to external energy directed toward the composite material.

[0365] A method as disclosed herein, wherein approximately 15 nL of fluid is exchanged between the peripheral fluid chamber and the optical fluid chamber in response to expansion of the composite material.

[0366] A method as disclosed herein, wherein adjusting a base power of an intraocular lens further comprises increasing the base power by directing external energy into a composite material configured as a space filler positioned within a peripheral fluid chamber defined within the peripheral portion.

[0367] The method as disclosed herein further includes reducing the base power by directing external energy to another instance of the composite material, the composite material being configured as a chamber expander positioned within the peripheral portion.

[0368] As disclosed herein, the method of adjusting the base power of the intraocular lens further comprises reducing the base power by directing external energy to a composite material configured as a chamber expander positioned within a peripheral fluid chamber defined within a peripheral portion.

[0369] A method as disclosed herein further includes reducing the base power by directing external energy to another instance of the composite material, the other instance of the composite material configured as a space filler positioned within the peripheral fluid chamber.

[0370] As disclosed herein, a method wherein adjusting the base power of an intraocular lens further comprises directing a pulse of external energy to a first peripheral component within a peripheral fluid chamber defined within a peripheral portion, wherein the first peripheral component is made of a composite material; and directing an additional pulse of external energy to a second peripheral component within the same peripheral fluid chamber, wherein the second peripheral component is made of a composite material.

[0371] As disclosed herein, a method wherein adjusting the base focal length of an intraocular lens further comprises directing a pulse of external energy to a first peripheral component within a first peripheral fluid chamber confined within a peripheral portion, wherein the first peripheral component is made of a composite material; and directing an additional pulse of external energy to a second peripheral component within a second peripheral fluid chamber confined within the peripheral portion, wherein the second peripheral component is made of a composite material.

[0372] A method as disclosed herein, wherein the first peripheral fluid chamber is in fluid communication with the second peripheral fluid chamber via an optical fluid chamber defined within the optical portion.

[0373] As disclosed herein, a method wherein the composite material comprises a first composite material and a second composite material, wherein the method further comprises: adjusting the base focal length in a first direction by directing external energy to the first composite material, wherein the first composite material comprises a first energy absorbing component having a first color; and adjusting the base focal length in a second direction by directing external energy to the second composite material, wherein the second composite material comprises a second energy absorbing component having a second color different from the first color.

[0374] The method as disclosed herein, wherein the expandable component is an expandable microsphere, and wherein each of the expandable microspheres comprises a blowing agent contained within a thermoplastic shell.

[0375] The method as disclosed herein further comprises adjusting the base power of the intraocular lens between about ±0.05D and about ±0.50D by directing pulses of external energy to the composite material.

[0376] A method as disclosed herein further comprising adjusting the base power of the intraocular lens by approximately ±0.10D by directing a pulse of external energy toward the composite material.

[0377] The method as disclosed herein further comprises adjusting the base power of the intraocular lens by a total of between about ±1.0D and about ±2.0D by directing a plurality of pulses of external energy to the composite material.

[0378] The method as disclosed herein, wherein directing external energy toward the composite material further comprises directing light energy toward the composite material.

[0379] The method as disclosed herein, wherein directing external energy toward the composite material further comprises directing a laser toward the composite material.

[0380] The method as disclosed herein, wherein directing external energy toward the composite material further comprises directing a green laser toward the composite material.

[0381] The method as disclosed herein, wherein directing external energy toward the composite material further comprises directing a laser having a wavelength between about 488 nm and about 650 nm toward the composite material.

[0382] The method as disclosed herein, wherein directing external energy toward the composite material further comprises directing a laser having a wavelength between about 946 nm and about 1120 nm toward the composite material.

[0383] Many embodiments have been described. However, it will be understood by those skilled in the art that various changes and modifications may be made to the present disclosure without departing from the spirit and scope of the embodiments. The elements of the systems, devices, apparatuses, and methods shown in conjunction with any embodiment are exemplary for a particular embodiment and may be used in combination or otherwise in other embodiments within the present disclosure. For example, the steps of any method depicted in the figures or described in this disclosure do not require the specific order or sequence shown or described to achieve the desired result. In addition, other step operations may be provided, or steps or operations may be eliminated or omitted from the described method or process to achieve the desired result. In addition, any component or portion of any device or system described in this disclosure or depicted in the figures may be removed, eliminated, or omitted to achieve the desired result. In addition, for the sake of brevity and clarity, some components or portions of the systems, devices, or apparatus shown or described herein have been omitted.

[0384] Accordingly, other embodiments are within the scope of the appended claims, and the specification and / or drawings are to be regarded as illustrative rather than restrictive.

[0385] Each individual variation or embodiment described and illustrated herein has discrete components and features that can be readily separated or combined with the features of any other variation or embodiment. Modifications may be made to adapt a particular situation, material, composition of matter, process, process(es), or step(s) to the objective(s), spirit, or scope of the present invention.

[0386] The methods recited herein may be performed in any order of the recited events that is logically possible, as well as in the recited order of events. Furthermore, additional steps or operations may be provided, or steps or operations may be eliminated to achieve the desired results.

[0387] Furthermore, where a range of values ​​is provided, each intervening value between the upper and lower limits of that range and any other specified or intervening values ​​within that stated range are encompassed within the invention. Furthermore, any optional feature of the described variations of the invention may be set forth and claimed independently or in combination with any one or more of the features described herein. For example, a description of a range from 1 to 5 should also be considered to have disclosed subranges such as from 1 to 3, from 1 to 4, from 2 to 4, from 2 to 5, from 3 to 5, etc., as well as individual numbers within that range, such as 1.5, 2.5, etc., and any whole or partial increments therebetween.

[0388] All prior subject matter (e.g., publications, patents, patent applications) mentioned herein are incorporated by reference in their entirety, except to the extent that such subject matter may conflict with the subject matter of the present invention (in which case the subject matter presented herein controls). The referenced items are provided solely for their disclosure prior to the filing date of the present application. Nothing herein should be construed as an admission that the present invention is not entitled to antedate such material by virtue of prior invention.

[0389] Reference to a singular item includes the possibility that there are multiple identical items. More specifically, as used herein and in the appended claims, the singular forms "a," "an," "said," and "the" include plural referents unless the context clearly dictates otherwise. It should also be noted that claims can be drafted to exclude any optional element. Thus, this statement is intended to serve as antecedent basis for the use of exclusive terminology such as "only" and "only" when referencing claim elements or using a "negative" limitation. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0390] Reference to the phrase "at least one of" when modifying multiple items or components (or an enumerated list of items or components) refers to any combination of one or more of those items or components. For example, the phrase "at least one of A, B, and C" refers to: (i) A; (ii) B; (iii) C; (iv) A, B, and C; (v) A and B; (vi) B and C; (vii) A and C.

[0391] In understanding the scope of the present disclosure, the term "comprising" and its derivatives as used herein are intended to be open terms that specify the presence of stated features, elements, parts, groups, integers and / or steps, but do not exclude the presence of other unstated features, elements, parts, groups, integers and / or steps. The foregoing also applies to words with similar meanings, such as the terms "comprising", "having" and their derivatives. In addition, when used in the singular, the terms "part", "section", "portion", "component", "element" or "part" can have the dual meaning of a single part or multiple parts. As used herein, the following directional terms "forward, backward, above, downward, vertical, horizontal, below, transverse, lateral and vertical" and any other similar directional terms refer to those positions of a device or equipment being translated or moved or those directions of a device or equipment.

[0392] Finally, as used herein, terms of degree such as "substantially," "about," and "approximately" refer to a specified value or a specified value and a reasonable amount of deviation therefrom (e.g., deviations of ±0.1%, ±1%, ±5%, or ±10%, as such variations are appropriate) such that the end result is not significantly or substantially changed. For example, "about 1.0 cm" can be interpreted to mean "1.0 cm" or "between 0.9 cm and 1.1 cm." When terms of degree such as "about" or "approximately" are used to refer to a number or value that is part of a range, the terms can be used to modify the minimum and maximum numbers or values.

[0393] The present disclosure is not intended to be limited to the scope of the particular forms set forth, but is intended to cover alternatives, modifications, and equivalents of the variants or embodiments described herein. In addition, the scope of the present disclosure fully encompasses other variants or embodiments that may become obvious to those skilled in the art in light of this disclosure.

Claims

1. An intraocular lens comprising: Optical part; a peripheral portion coupled to the optical portion; wherein the peripheral portion comprises a composite material including an energy absorbing component and a plurality of expandable components, wherein the base power of the optical portion is configured to change in response to external energy directed toward the composite material, and The base power of the optical portion is configured to be unresponsive to forces applied to the peripheral portion by the capsular bag when the intraocular lens is implanted within the capsular bag.

2. The intraocular lens of claim 1, wherein the expandable component is an expandable microsphere, and wherein each of the expandable microspheres comprises a blowing agent contained within a thermoplastic shell.

3. The intraocular lens of claim 1, wherein the energy absorbing component is an azo dye.

4. The intraocular lens of claim 1 , wherein the energy absorbing component is graphitized carbon black.

5. The intraocular lens of claim 1, wherein the peripheral portion is made in part of a cross-linked copolymer comprising a copolymer blend, and wherein the composite material is made in part of the copolymer blend.

6. The intraocular lens of claim 1 , wherein the base power of the optical portion is configured to vary between 0.05 D and 0.5 D in a positive or negative direction in response to a pulse of external energy directed at the composite material.

7. The intraocular lens of claim 1, wherein the external energy is laser light having a wavelength between 488 nm and 650 nm.

8. The intraocular lens of claim 1, wherein the external energy is laser light having a wavelength between 946 nm and 1120 nm.

9. The intraocular lens of claim 1, wherein the external energy is laser light emitted by a femtosecond laser.

10. The intraocular lens of claim 1 , wherein the composite material is formed into discrete peripheral components such that directing the external energy to one discrete peripheral component causes a change in the base power of the optical portion, and directing the external energy to another discrete peripheral component also causes a change in the base power of the optical portion.

11. The intraocular lens of claim 1 , wherein the optical portion comprises an optical fluid chamber, and the peripheral portion comprises at least one peripheral fluid chamber in fluid communication with the optical fluid chamber.

12. An intraocular lens as described in claim 11, wherein the composite material is configured as a chamber expander, wherein the chamber expander is configured to expand in response to external energy directed to the chamber expander, and wherein expansion of the chamber expander increases the volume of the peripheral fluid chamber.

13. The intraocular lens of claim 12, wherein the base power of the optical portion is configured to decrease in response to external energy directed to the chamber expander.

14. The intraocular lens of claim 12, wherein the chamber expander is configured as an expandable column extending from the anterior chamber wall to the posterior chamber wall.

15. The intraocular lens of claim 11, wherein the composite material is configured as a space filler, wherein the space filler is configured to expand in response to external energy directed toward the space filler, and wherein expansion of the space filler reduces the volume of the peripheral fluid chamber.

16. The intraocular lens of claim 15, wherein the base power of the optical portion is configured to increase in response to external energy directed toward the space filler.

17. The intraocular lens of claim 11, wherein the peripheral portion is configured as at least one haptic, wherein the peripheral fluid chamber is defined within the haptic, wherein the peripheral fluid chamber extends only partially into the haptic.

18. The intraocular lens of claim 1, wherein the peripheral portion is configured as a first haptic comprising a first haptic fluid chamber and a second haptic comprising a second haptic fluid chamber, and wherein the optical portion comprises an optical fluid chamber.

19. The intraocular lens of claim 18, wherein the first tactile fluid chamber is in fluid communication with the optical fluid chamber via a first fluid channel, wherein the second tactile fluid chamber is in fluid communication with the optical fluid chamber via a second fluid channel, and wherein the first fluid channel is positioned radially opposite to the second fluid channel.

20. The intraocular lens of claim 18, wherein the optical fluid chamber, the first tactile fluid chamber, and the second tactile fluid chamber comprise a total fluid volume of between 10 μL and 20 μL of fluid.

21. The intraocular lens of claim 20, wherein each of the first tactile fluid chamber and the second tactile fluid chamber comprises 0.5 μL of fluid.

22. The intraocular lens of claim 20, wherein 15 nL of fluid is exchanged between the first and second haptic fluid chambers and the optical fluid chamber in response to expansion of the composite material.

23. The intraocular lens of claim 1 , wherein the peripheral portion comprises a first composite material and a second composite material, wherein the first composite material comprises a first energy absorbing component and the second composite material comprises a second energy absorbing component, wherein the color of the first energy absorbing component is different from the color of the second energy absorbing component.

24. An intraocular lens comprising: Optical part; as well as a peripheral portion coupled to the optical portion, wherein the peripheral portion includes a first peripheral component and a second peripheral component, wherein the first peripheral component is made of a composite material comprising an energy absorbing component and a plurality of expandable components, wherein said second peripheral component is made of said composite material comprising said energy absorbing component and said plurality of expandable components, wherein the base power of the optical portion is configured to increase in response to external energy directed toward the first peripheral component, wherein the base power of the optical portion is configured to decrease in response to external energy directed toward the second peripheral component, and wherein the base power of the optical portion is configured to be unresponsive to forces applied to the peripheral portion by a capsular bag.

25. The intraocular lens of claim 24, wherein the optical portion comprises an optical fluid chamber and the peripheral portion comprises at least one peripheral fluid chamber in fluid communication with the optical fluid chamber.

26. The intraocular lens of claim 25, wherein the first peripheral component is configured as a space filler, wherein the space filler is configured to expand in response to external energy directed toward the space filler, and wherein expansion of the space filler reduces the volume of the peripheral fluid chamber.

27. An intraocular lens as described in claim 25, wherein the second peripheral component is configured as a chamber expander, wherein the chamber expander is configured to expand in response to external energy directed to the chamber expander, and wherein expansion of the chamber expander increases the volume of the peripheral fluid chamber.

28. The intraocular lens of claim 25, wherein the first peripheral component and the second peripheral component are located within the same peripheral fluid chamber.

29. The intraocular lens of claim 28, wherein the second peripheral component is positioned distally from the first peripheral component within the same peripheral fluid chamber.

30. The intraocular lens of claim 28, wherein the first peripheral component is positioned proximate to the second peripheral component within the same peripheral fluid chamber, and wherein the first peripheral component is positioned closer to a fluid channel connecting the optical fluid chamber to the peripheral fluid chamber than the second peripheral component.

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