Contact lens type wireless flexible electroretinogram signal detection system and method

Abstract

The embodiment of the present application discloses a contact lens type wireless flexible electroretinogram signal detection system and method. The system comprises an energy transmission device and a contact lens type electroretinogram detection device; wherein: the energy transmission device worn in front of the eyes comprises a signal generating circuit and an energy transmitting coil, the energy transmission device acquires an electric signal and wirelessly transmits the electric signal to the contact lens type electroretinogram detection device; the contact lens type electroretinogram detection device worn on the surface of the eyeball comprises a signal collecting electrode, an energy receiving coil and a signal processing main chip, the energy receiving coil wirelessly receives the electric signal to drive the signal processing main chip, and the electroretinogram signal acquired by the signal collecting electrode from the cornea is wirelessly transmitted to a host computer for display after being processed by the signal processing main chip. The technical scheme of the embodiment of the present application combines flexible electronic technology and a signal processing main chip, condenses a set of large electroretinogram detection system on a piece of contact lens type flexible device, and realizes a small-sized and wireless visual electrophysiological instrument.

Description

Technical Field

[0001] The embodiments of the present invention relate to the field of ophthalmic medical technology, and in particular to a contact lens-type wireless flexible electroretinogram signal detection system and method. Background Art

[0002] Electroretinogram is an important diagnostic method for retinal diseases in ophthalmic electrophysiological examinations. Due to its high diagnostic accuracy and harmlessness to the body, it is an ophthalmic examination method that is highly accepted by doctors and examinees.

[0003] However, the most advanced electroretinogram (ERG) instruments currently used in clinical practice are large, heavy, and expensive, wasting medical resources. The wiring is cumbersome, and the wires need to be attached to the subject's body to prevent significant displacement. Slight disturbances in the surrounding environment can cause large fluctuations in the collected signals. The instrument has a complex structure and consists of multiple components. The new corneal electrode still needs to be connected to a large external signal processing device via a commercial wire, which not only restricts the subject's activities but also requires professional medical personnel to operate, making it inconvenient for home testing.

[0004] Therefore, how to make the electroretinogram detection system miniaturized, wireless, and household-friendly may become a technical problem that needs to be solved urgently by those skilled in the art. Summary of the Invention

[0005] The embodiment of the present invention provides a contact lens-type wireless flexible electroretinogram signal detection system and method, which combines flexible electronic technology and a signal processing main chip to concentrate a large electroretinogram detection system on a contact lens-type flexible device, thereby realizing miniaturization and wireless transmission of signals.

[0006] In a first aspect, an embodiment of the present invention provides a contact lens-type wireless flexible electroretinogram signal detection system, the system comprising: an energy transmission device and a contact lens-type electroretinogram detection device; wherein: the energy transmission device worn in front of the eye comprises a signal generating circuit and an energy transmitting coil, the energy transmission device acquires an electrical signal and wirelessly transmits the electrical signal to the contact lens-type electroretinogram detection device;

[0007] The contact lens-type electroretinogram detection device worn on the surface of the eyeball includes a signal acquisition electrode, an energy receiving coil and a signal processing main chip. The energy receiving coil wirelessly receives the electrical signal to drive the signal processing main chip, and the electroretinogram signal obtained from the cornea by the signal acquisition electrode is processed by the signal processing main chip and then wirelessly transmitted to the host computer for display.

[0008] In a second aspect, an embodiment of the present invention further provides a contact lens-type wireless flexible electroretinogram signal detection method, comprising:

[0009] Acquiring an electrical signal and wirelessly transmitting the electrical signal to a contact lens type electroretinogram detection device;

[0010] The electrical signal is received to drive the signal processing main chip, and the electroretinogram signal obtained from the cornea by the signal acquisition electrode is processed by the signal processing main chip and then wirelessly transmitted to the host computer for display.

[0011] An embodiment of the present invention provides a contact lens-type wireless flexible electroretinogram (ERG) signal detection system and method. An energy transmission device worn in front of the eye includes a signal generating circuit and an energy transmitting coil. The energy transmission device acquires electrical signals and wirelessly transmits the electrical signals to a contact lens-type ERG detection device. The contact lens-type ERG detection device, worn on the surface of the eyeball, includes a signal acquisition electrode, an energy receiving coil, and a signal processing main chip. The energy receiving coil wirelessly receives the electrical signals to drive the signal processing main chip. The ERG signals acquired from the cornea by the signal acquisition electrode are processed by the signal processing main chip and then wirelessly transmitted to a host computer for display. By adopting the technical solution of the embodiment of the present invention, combined with flexible electronic technology and a signal processing main chip, a large ERG detection system is concentrated on a contact lens-type flexible device, achieving miniaturization and wireless signal transmission. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Other features, objects, and advantages of the present invention will become more apparent upon reading the detailed description of non-limiting embodiments made with reference to the following drawings. The drawings are for the purpose of illustrating preferred embodiments only and are not to be considered as limiting the present invention. Like reference characters are used throughout the drawings to denote like parts. In the drawings:

[0013] Figure 1 1 is a schematic structural diagram of a contact lens-type wireless flexible electroretinogram signal detection system provided in an embodiment of the present invention;

[0014] Figure 2 1 is a schematic structural diagram of another contact lens-type wireless flexible electroretinogram signal detection device provided in an embodiment of the present invention;

[0015] Figure 3 This is a schematic structural diagram of a contact lens type electroretinogram detection device provided by an embodiment of the present invention;

[0016] Figure 4 This is a schematic structural diagram of the main body of a contact lens type electroretinogram detection device provided by an embodiment of the present invention;

[0017] Figure 5 This is a schematic diagram of the structure of a signal processing main chip provided by an embodiment of the present invention;

[0018] Figure 6 is a structural schematic diagram of a retinal electrogram signal detection based on a flexible substrate miniaturized circuit provided by an embodiment of the present application;

[0019] Figure 7 is a flowchart of a contact lens type wireless flexible retinal electrogram signal detection system method provided by an embodiment of the present application. DETAILED DESCRIPTION

[0020] The present application will be further described below in conjunction with the accompanying drawings and embodiments. It can be understood that the specific embodiments described herein are only used to explain the present application, but not to limit the present application. In addition, it should be noted that, for the convenience of description, only the parts related to the present application are shown in the drawings, but not all the structures.

[0021] Before discussing the example embodiments in more detail, it should be mentioned that some of the example embodiments are described as processes or methods depicted as flowcharts. Although the flowcharts describe the operations (or steps) as sequential processes, many of the operations (or steps) can be implemented in parallel, concurrently or simultaneously. In addition, the order of the operations can be rearranged. The processes can be terminated when their operations are completed, but can also have additional steps not included in the drawings. The processes can correspond to methods, functions, procedures, subroutines, subprograms, etc.

[0022] Retinal electrogram is an important diagnostic method for retinal-related diseases in ophthalmic electrophysiological examination. After full-field light stimulation of the eye, the photoreceptor cells on the retina are activated to generate electricity and transmit to the cornea. Based on the electricity waveform (i.e. retinal electrogram signal) collected from the cornea, it can accurately represent whether the important visual source structure of the retinal cone cells and rod cells is intact or not. It has important significance for the diagnosis of various fundus diseases such as retinal pigmentosa. Because of its high diagnostic accuracy and no harm to the body, retinal electrogram detection is an ophthalmic examination method with high acceptance of doctors and patients.

[0023] The amplitude of the electroretinogram signal is small (tens of microvolts to hundreds of microvolts), and the frequency component is complex, so its detection is difficult. At present, the most advanced electroretinogram detection instrument commonly used in clinical practice, such as the electroretinogram detection system of German Roland Company, includes a huge hollow light collecting dome, a signal processing machine box, a data processing and display device, a wired corneal electrode, and a number of cumbersome wires. The examinee is required to sit still in front of the dome, the light source is inside the dome, the light is reflected and concentrated on an opening on the wall of the dome by the inner wall of the dome, the examinee's eyes are attached to the opening, and full-field light stimulation is performed. The wired electrode leads out from the cornea, and the electroretinogram signal is transmitted to the signal processing machine box through the long wire, and the processed signal is transmitted to the data processing and display device through the long wire.

[0024] As described above, the most advanced electroretinogram detection instrument commonly used in clinical practice at present is large in size and weight and high in cost, a set of equipment needs to occupy a whole room, wasting medical resources; the wiring is cumbersome, and the wires need to be pasted on the examinee's body to ensure that the wires do not move greatly, and slight disturbance in the surrounding environment will cause large fluctuations in the collected signal; the instrument structure is complex, composed of multiple components, which not only limits the examinee's activity, but also requires professional medical personnel to operate, and is not convenient for home detection.

[0025] In view of the above problems, in recent years, there have also been frontier scientific researches to improve the electroretinogram detection equipment. For example, by taking advantage of the transparency, conductivity and easy processing of graphene, the situation that the examinee's vision is blocked and the wire is led out from the center of the cornea in clinical electroretinogram detection is improved. By using special materials such as conductive polymers and combining 3D printing technology, a new type of corneal electrode for electroretinogram detection is provided, which has better signal quality than the existing commercial electrode. However, this kind of work only improves the corneal electrode itself, and does not optimize the subsequent signal processing equipment, and the electrode still needs to be connected to the large external signal processing equipment through a commercial wire. Therefore, the embodiment of the present application provides a contact lens type wireless flexible electroretinogram signal detection system, which is based on flexible polymer materials and flexible metal structure design, realizes the overall structure of flexible, lightweight and high adhesion to the skin; based on the signal processing main chip, realizes the wireless and small signal acquisition and processing structure. The present application has the advantages of simple structure, small size and weight, and easy operation, which makes the miniaturization, wireless and home of the electroretinogram detection system possible.

[0026] Figure 1 It is a structure schematic diagram of a contact lens type wireless flexible electroretinogram signal detection system provided in the embodiment of the present application, and the embodiment can be applied to the case of using the contact lens type wireless flexible electroretinogram signal detection system for electroretinogram detection, such as Figure 1As shown, the contact lens type wireless flexible electroretinogram signal detection system provided in the embodiment of the present invention may include: an energy transmission device 110 and a contact lens type electroretinogram detection device 120;

[0027] The energy transmission device 110 worn in front of the eyes includes a signal generating circuit and an energy transmitting coil. The energy transmission device acquires an electrical signal and wirelessly transmits the electrical signal to a contact lens type electroretinogram detection device.

[0028] The contact lens-type electroretinogram detection device 120 worn on the surface of the eyeball includes a signal acquisition electrode, an energy receiving coil and a signal processing main chip. The energy receiving coil wirelessly receives the electrical signal to drive the signal processing main chip. The electroretinogram signal obtained from the cornea by the signal acquisition electrode is processed by the signal processing main chip and then wirelessly transmitted to the host computer for display.

[0029] The energy transmission device 110 may refer to a device worn in front of the eyes of the subject, used to provide electrical signals for the contact lens type electroretinogram detection device.

[0030] In an optional solution of the embodiment of the present invention, the energy transmission device may be frame glasses. Figure 2 This is a schematic diagram of the structure of another contact lens type wireless flexible electroretinogram signal detection device provided in an embodiment of the present invention, see Figure 2 The temples of the frame glasses worn in front of the eyes are integrated with a signal generating circuit 1 for inputting an electrical signal with the same frequency as the resonant frequency to the energy transmitting coil 2; the lenses of the frame glasses are integrated with an energy transmitting coil 2 for wirelessly transmitting an electrical signal with the same frequency as the resonant frequency of the energy receiving coil 3 to the energy receiving coil 3. In an embodiment of the present invention, based on the magnetic resonance coupling coil, wireless power supply of the device is achieved through the energy transmitting coil integrated in the frame glasses. The energy transmission frame glasses worn in front of the eyes have a signal generating circuit integrated in the temples, which inputs a MHz-level voltage signal to the energy transmitting coil wound in the frame, so that the energy receiving coil with the same resonant frequency as the energy transmitting coil receives an electrical signal to drive the signal processing main chip.

[0031] Among them, the contact lens type electroretinogram detection device 120 can refer to a polymer insulating substrate 4 that wraps the energy receiving coil 3, signal processing main chip 7, signal acquisition electrode 8 and signal processing unit 9 in a flexible material shell 6, and is processed into an electroretinogram detection device that fits on the surface of the eyeball.

[0032] Figure 3 This is a schematic diagram of the structure of a contact lens type electroretinogram detection device provided by an embodiment of the present invention, see Figure 3The energy transmitting coil 2 wirelessly transmits electrical signals to the energy receiving coil 3 based on the principle of magnetic resonance coupling. The electrical signals are then processed by the main signal processing chip in the drive circuit. The main body of the contact lens-type electroretinogram detection device is enclosed in a flexible material housing 6, which is made of a flexible polymer material including, but not limited to, silicone hydrogel and poly(hydroxyethyl methacrylate). A micron-sized flexible wire 5 connects the ground electrode to the main signal processing chip. The micron-sized flexible wire is a metal material encased in a flexible polymer and fits snugly against the skin, thus avoiding various signal disturbances that may be caused by conventional wires.

[0033] In the embodiment of the present invention, a flexible and lightweight electroretinogram detection device is realized based on a biocompatible flexible polymer material and a flexible metal structure design.

[0034] The energy receiving coil 3 receives the electrical signal transmitted wirelessly by the energy transmitting coil 2 and sends the electrical signal to the signal processing unit; the energy receiving coil 3 has the same resonant frequency as the energy transmitting coil 2 and is aligned within a preset range.

[0035] Optionally, the signal processing unit 9 converts the electrical signal into a direct current signal through rectification and voltage stabilization. The electrical signal received by the energy receiving coil 3 is an alternating current signal, which is converted into a direct current signal by the signal processing unit 9. The direct current signal drives the main signal processing chip to process the electroretinogram signal collected by the signal collection electrode.

[0036] Optionally, the signal collection electrode 8 acquires the electroretinogram signal and sends the electroretinogram signal to the signal processing main chip 7 through a micron-level flexible wire.

[0037] In an optional solution of the embodiment of the present invention, the signal collection electrode 8 can be a bipolar application mode or a tripolar application mode. The signal collection electrode 8 includes but is not limited to a working electrode 81, a recovery electrode 82 and a ground electrode 83. Figure 4 This is a schematic diagram of the main structure of a contact lens type electroretinogram detection device provided by an embodiment of the present invention, see Figure 4 The working electrode 81 is attached to the center of the cornea; the recovery electrode 82 can present Figure 4The point electrode shown in the middle can also be a circular ring electrode around the conjunctiva, which is attached to the conjunctiva or the canthus, etc. In the dual electrode application mode, the ground electrode 83 can not exist, and the recovery electrode 82 is used as the ground electrode in the dual electrode system; and in the three electrode mode, the ground electrode 83 near the forehead is introduced into the signal processing main chip 7 of the contact lens type retinal electrograph detection device main device through a micron-level flexible lead closely attached to the skin, which can eliminate the disturbance caused by the displacement and deformation of the traditional lead.

[0038] Optionally, the signal processing main chip transmits the retinal electrograph signal to the upper computer 11 for display after pre-processing. The signal processing main chip includes but is not limited to a low-power Bluetooth processing chip, Figure 5 is a signal processing main chip structure schematic diagram provided by an embodiment of the application, referring to Figure 5 The retinal electrograph signal obtained by the signal acquisition electrode is input into the signal processing main chip, the retinal electrograph signal is amplified by an amplification circuit and transmitted to a filter for band-pass filtering, then the retinal electrograph signal is input into a central processing unit of the signal processing main chip for software processing, and finally transmitted to the upper computer for display through a wireless transmission module. In an optional solution of the embodiment of the application, a low-power Bluetooth processing chip is used as the signal processing main chip. The low-power Bluetooth processing chip is an integrated chip, which integrates a low-power Bluetooth wireless transmission module, a central processing unit, a memory and a signal processing module. The functional modules are wrapped in a biocompatible high-oxygen permeability polymer material to meet the clinical application requirements of the contact lens type device. The low-power Bluetooth processing chip transmits the obtained retinal electrograph signal to the upper computer, so that the doctor can remotely obtain relevant information and realize the concept of precision medicine.

[0039] In an optional solution of the embodiment of the application, the contact lens type retinal electrograph detection function can also be realized by a small-sized circuit based on a flexible substrate in addition to the signal processing main chip. Figure 6 is a structure schematic diagram of a retinal electrograph signal detection based on a small-sized circuit based on a flexible substrate provided by an embodiment of the application, referring to Figure 6The flexible substrate miniaturized circuit includes the energy transmitting coil, energy receiving coil, and signal processing unit described in the above embodiment; the working electrode 81 located on the cornea and the recovery electrode 82 located at the canthus of the eye are both led out from the canthus of the eye via micron-level flexible wires, adhered to the skin near the forehead, and input into the signal processing device 10 together with the ground electrode 83 near the forehead. The function of the signal processing device 10 is equivalent to the expansion of the signal processing main chip in the above example. The signal processing device 10 is based on a flexible polymer material and a flexible metal circuit structure design, which realizes the flexibility of the circuit and high conformability to the skin. The electroretinogram signal processed by the signal processing device 10 is wirelessly transmitted to the host computer, which can be displayed, stored, and uploaded for access by doctors and patients.

[0040] The embodiment of the present invention provides a contact lens-type wireless flexible electroretinogram signal detection system. Based on a flexible polymer material and a flexible metal structure design, the overall structure of the device is flexible, lightweight, and highly conformable to the skin. Based on a signal processing main chip, a wireless and miniaturized signal acquisition and processing structure is realized. Based on the principle of magnetic resonance coupling, an electroretinogram detection instrument model is provided that only requires wearing a contact lens and frame glasses, overcoming many shortcomings of related clinical instruments and cutting-edge research devices. The present invention combines flexible electronic technology and a signal processing main chip to condense a large electroretinogram detection system into a contact lens-type flexible device, so that the subject only needs to wear a contact lens to achieve electroretinogram detection, making it possible to use the electroretinogram detection system at home. The technical solution of the embodiment of the present invention adopts a wireless and intelligent design, giving electroretinogram detection the potential for wireless, flexible, home-based, and intelligent use, allowing doctors to remotely obtain the subject's electroretinogram information, realizing a doctor-patient model of precision medicine, and conforming to the modern medical development concept of precision medicine.

[0041] Figure 7 This is a flow chart of a contact lens type wireless flexible electroretinogram signal detection system method provided in an embodiment of the present invention. The embodiment of the present invention is applicable to the case where the contact lens type wireless flexible electroretinogram signal detection system is used to detect the electroretinogram. The method can be executed by the contact lens type wireless flexible electroretinogram signal detection system provided in any embodiment of the present invention. Figure 7 As shown, the contact lens-type wireless flexible electroretinogram signal detection method provided in the embodiment of the present invention specifically includes the following steps:

[0042] S710 , acquiring an electrical signal and wirelessly transmitting the electrical signal to a contact lens-type electroretinogram detection device.

[0043] Among them, the energy transmission device worn in front of the eyes includes a signal generating circuit and an energy transmitting coil.

[0044] Based on the above embodiment, optionally, the energy receiving coil receives an electrical signal wirelessly transmitted by the energy transmitting coil and sends the electrical signal to a signal processing unit; wherein the energy receiving coil and the energy transmitting coil have the same resonant frequency and are aligned within a preset range.

[0045] Based on the above embodiment, optionally, the signal generating circuit inputs an electrical signal having the same frequency as the resonant frequency into the energy transmitting coil.

[0046] Based on the above embodiment, optionally, the energy transmitting coil receives the electrical signal and wirelessly transmits it to the energy receiving coil.

[0047] S720: Receive the electrical signal to drive the signal processing main chip, and wirelessly transmit the electroretinogram signal acquired from the cornea by the signal acquisition electrode to the host computer for display after being processed by the signal processing main chip.

[0048] The contact lens type electroretinogram detection device includes a signal acquisition electrode, an energy receiving coil and a signal processing main chip.

[0049] Based on the above embodiment, optionally, the signal processing unit converts the electrical signal into a direct current signal through rectification and voltage stabilization.

[0050] Based on the above embodiment, optionally, the signal acquisition electrodes are attached to the center of the cornea, the conjunctiva, and the canthus to obtain the electroretinogram signal transmitted from the retina to the cornea.

[0051] Based on the above embodiments, optionally, in a bipolar application mode, the signal acquisition electrode includes a ground electrode and a working electrode; in a tripolar application mode, the signal acquisition electrode includes a recovery electrode, a ground electrode and a working electrode, the ground electrode is led out from the canthus of the eye through a micron-level flexible wire and adheres to the skin, and the end disc-shaped electrode adheres to the skin near the forehead.

[0052] Based on the above embodiment, optionally, the signal processing main chip wirelessly transmits the electroretinogram signal after pre-processing to a host computer for display.

[0053] Based on the above embodiments, optionally, the contact lens type electroretinogram detection device is composed of a polymer insulating substrate that carries the energy receiving coil, signal processing main chip, signal acquisition electrode and signal processing unit, and is wrapped in a flexible material shell and processed into an electroretinogram detection device that fits on the surface of the eyeball.

[0054] The contact lens-type wireless flexible electroretinogram signal detection method provided in the embodiments of the present invention can be applied to the contact lens-type wireless flexible electroretinogram signal detection system provided in any of the above-mentioned embodiments of the present invention, and has the corresponding functions and beneficial effects of the contact lens-type wireless flexible electroretinogram signal detection system. For technical details not described in detail in the above-mentioned embodiments, please refer to the contact lens-type wireless flexible electroretinogram signal detection system provided in any embodiment of the present application.

[0055] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "examples," "specific examples," or "some examples" means that a specific feature, structure, material, or characteristic described in conjunction with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0056] Note that the above are only preferred embodiments of the present invention and the technical principles employed. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and that various obvious changes, readjustments, and substitutions can be made by those skilled in the art without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in detail through the above embodiments, the present invention is not limited to the above embodiments and may include many other equivalent embodiments without departing from the concept of the present invention. The scope of the present invention is determined by the scope of the appended claims.

Claims

1. A contact lens type wireless flexible electroretinogram signal detection system, characterized in that: The system comprises: an energy transmission device and a contact lens type electroretinogram detection device; wherein: The energy transmission device worn in front of the eyes includes a signal generating circuit and an energy transmitting coil, and the energy transmission device acquires an electrical signal and wirelessly transmits the electrical signal to a contact lens type electroretinogram detection device; The contact lens-type electroretinogram detection device worn on the surface of the eyeball includes a signal acquisition electrode, an energy receiving coil, a signal processing unit and a signal processing main chip. The energy receiving coil wirelessly receives the electrical signal to drive the signal processing main chip. The electroretinogram signal obtained from the cornea by the signal acquisition electrode is processed by the signal processing main chip and then wirelessly transmitted to the host computer for display; wherein, the signal processing main chip includes a low-power Bluetooth processing chip, and the low-power Bluetooth processing chip integrates a low-power Bluetooth wireless transmission module, a central processing unit, a memory and a signal processing module.

2. The system according to claim 1, wherein: The energy receiving coil receives the electrical signal transmitted wirelessly by the energy transmitting coil and sends the electrical signal to the signal processing unit; wherein the energy receiving coil and the energy transmitting coil have the same resonant frequency and are aligned in a preset range.

3. The system according to claim 1, wherein: The signal generating circuit inputs an electrical signal having the same frequency as the resonant frequency into the energy transmitting coil.

4. The system according to claim 1, wherein: The energy transmitting coil receives the electrical signal and wirelessly transmits it to the energy receiving coil.

5. The system according to claim 1, wherein: The signal processing unit converts the electrical signal into a direct current signal through rectification and voltage stabilization.

6. The system according to claim 1, wherein: The signal collection electrodes are attached to the center of the cornea, conjunctiva and canthus to obtain the electroretinogram signal transmitted from the retina to the cornea.

7. The system according to claim 6, characterized in that In the bipolar application mode, the signal acquisition electrode includes a ground electrode and a working electrode; in the tripolar application mode, the signal acquisition electrode includes a recovery electrode, a ground electrode and a working electrode. The ground electrode is led out from the canthus of the eye through a micron-level flexible wire and adheres to the skin, and the end disc-shaped electrode adheres to the skin near the forehead.

8. The system according to claim 1, wherein: The signal processing main chip wirelessly transmits the electroretinogram signal after pre-processing to the host computer for display.

9. The system according to claim 1, wherein: The contact lens type electroretinogram detection device is composed of a polymer insulating substrate that carries the energy receiving coil, signal processing main chip, signal acquisition electrode and signal processing unit, and is wrapped in a flexible material shell, and is processed into an electroretinogram detection device that fits and is worn on the surface of the eyeball.

10. A method for detecting electroretinogram signals using the contact lens type wireless flexible electroretinogram signal detection system according to any one of claims 1 to 9, characterized in that: The method comprises: Acquiring an electrical signal and wirelessly transmitting the electrical signal to a contact lens type electroretinogram detection device; The electrical signal is received to drive the signal processing main chip, and the electroretinogram signal obtained by the signal acquisition electrode from the cornea is processed by the signal processing main chip and then wirelessly transmitted to the host computer for display; wherein, the signal processing main chip includes a low-power Bluetooth processing chip, and the low-power Bluetooth processing chip integrates a low-power Bluetooth wireless transmission module, a central processing unit, a memory and a signal processing module.

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