Transcranial magnetic stimulation target determination system and method

Abstract

The present invention discloses a transcranial magnetic stimulation target determination system and method, the system includes: a signal acquisition module, a signal processing module and a target determination module; wherein the signal acquisition module is used to obtain the electrocardiogram signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation targets, and send the electrocardiogram signal to the signal processing module; the signal processing module is connected to the signal acquisition module, and is used to receive the electrocardiogram signal, process the electrocardiogram signal, obtain the R peak detection signal, and send the R peak detection signal to the target determination module; the target determination module is connected to the signal processing module, and is used to obtain the R peak detection signal, and according to the R peak detection signal, determine the target target from at least two stimulation targets for transcranial magnetic stimulation of the target object. Through the technical solution of the embodiment of the present invention, the technical effect of accurately determining the target position according to the electrocardiogram signal is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of transcranial magnetic stimulation, and in particular to a transcranial magnetic stimulation target determination system and method. Background Art

[0002] Repetitive transcranial magnetic stimulation (rTMS) can relieve the symptoms of patients with refractory depression. At present, clinical treatment usually places the transcranial magnetic stimulation coil in the dorsolateral prefrontal cortex (DLPFC). The magnetic field is generated by the rapidly changing current in the coil, and the current is induced in the DLPFC cortex, so that the cortical neurons in the corresponding area are induced to discharge, generating evoked potentials, which are transmitted to the neurons along the axons. The symptoms of patients with depression are alleviated by regulating the local cortex and brain network of the cerebral cortex through non-invasive means.

[0003] The therapeutic effect of repetitive transcranial magnetic stimulation is strongly correlated with the stimulation target. Currently, transcranial magnetic stimulation positioning can be performed using the "5 cm" method. However, since this method does not take into account differences in head size or anatomical structure, it will cause non-related cerebral cortex to be stimulated, which will lead to poor results when using rTMS for treatment. Summary of the invention

[0004] The present invention provides a transcranial magnetic stimulation target determination system and method to solve the problem of inaccurate target position determination during transcranial magnetic stimulation, and achieve the technical effect of accurately determining the target position according to electrocardiogram signals.

[0005] According to one aspect of the present invention, a transcranial magnetic stimulation target determination system is provided, the system comprising: a signal acquisition module, a signal processing module and a target determination module; wherein:

[0006] The signal acquisition module is used to acquire the electrocardiogram signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points, and send the electrocardiogram signal to the signal processing module;

[0007] The signal processing module is connected to the signal acquisition module, and is used to receive the ECG signal, process the ECG signal, obtain an R-peak detection signal, and send the R-peak detection signal to the target point determination module;

[0008] The target point determination module is connected to the signal processing module, and is used to obtain the R peak detection signal, and determine the target point from at least two stimulation target points for transcranial magnetic stimulation of the target object according to the R peak detection signal.

[0009] According to another aspect of the present invention, a method for determining a transcranial magnetic stimulation target is provided, the method comprising:

[0010] Based on the signal acquisition module, an electrocardiogram signal of the target object is obtained when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points, and the electrocardiogram signal is sent to the signal processing module;

[0011] Based on the signal processing module, the electrocardiogram signal is received, the electrocardiogram signal is processed to obtain an R peak detection signal, and the R peak detection signal is sent to the target point determination module;

[0012] Based on the target point determination module, the R peak detection signal is acquired, and according to the R peak detection signal, a target point is determined from at least two stimulation target points for transcranial magnetic stimulation of the target object.

[0013] The technical solution of the embodiment of the present invention obtains the electrocardiogram (ECG) signal of the target object when transcranial magnetic stimulation is performed on the target object through at least two stimulation target points through a signal acquisition module, receives the ECG signal based on the signal processing module, processes the ECG signal to obtain an R-peak detection signal, obtains the R-peak detection signal based on the target point determination module, and determines the target point from at least two stimulation target points for transcranial magnetic stimulation of the target object according to the R-peak detection signal, thereby solving the problem of inaccurate target point positioning during transcranial magnetic stimulation and achieving the technical effect of accurately determining the target point position according to the ECG signal.

[0014] It should be understood that the contents described in this section are not intended to identify the key or important features of the embodiments of the present invention, nor are they intended to limit the scope of the present invention. Other features of the present invention will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0016] Figure 1 A schematic diagram of the structure of a transcranial magnetic stimulation target determination system provided in Embodiment 1 of the present invention;

[0017] Figure 2 A schematic diagram of the structure of a transcranial magnetic stimulation target determination system provided in Embodiment 2 of the present invention;

[0018] Figure 3A schematic diagram of the structure of another transcranial magnetic stimulation target determination system provided in Embodiment 2 of the present invention;

[0019] Figure 4 A waveform diagram of a target point determination method provided in the second embodiment of the present invention;

[0020] Figure 5 This is a schematic flow chart of a method for determining a transcranial magnetic stimulation target provided in Embodiment 3 of the present invention. DETAILED DESCRIPTION

[0021] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0022] It should be noted that the terms "preset", "target", etc. in the specification and claims of the present invention and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchanged where appropriate, so that the embodiments of the present invention described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "for" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0023] It is understandable that the data involved in this technical solution (including but not limited to the data itself, the acquisition or use of the data) shall comply with the requirements of relevant laws, regulations and relevant provisions.

[0024] Embodiment 1

[0025] Figure 1 This is a schematic diagram of the structure of a transcranial magnetic stimulation target determination system provided in Embodiment 1 of the present invention. This embodiment can be applied to the case of determining transcranial magnetic stimulation targets. The system can execute a transcranial magnetic stimulation target determination method. The transcranial magnetic stimulation target determination system can be implemented in the form of hardware and / or software. The transcranial magnetic stimulation target determination system can be configured in a transcranial magnetic stimulation system. Figure 1 As shown, the system includes: a signal acquisition module 1, a signal processing module 2 and a target determination module 3.

[0026] Among them, the signal acquisition module 1 is used to obtain the ECG signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points, and send the ECG signal to the signal processing module 2; the signal processing module 2 is connected to the signal acquisition module 1, and is used to receive the ECG signal, process the ECG signal, obtain the R-peak detection signal, and send the R-peak detection signal to the target determination module 3; the target determination module 3 is connected to the signal processing module 2, and is used to obtain the R-peak detection signal, and determine the target point from at least two stimulation target points for transcranial magnetic stimulation of the target object according to the R-peak detection signal.

[0027] The signal acquisition module 1 is used to obtain the ECG signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points, and send the ECG signal to the signal processing module 2.

[0028] Among them, the stimulation target can be an alternative target selected in the subsequent transcranial magnetic stimulation, for example: stimulating three different positions of the left dorsolateral prefrontal cortex (DLPFC) of the cortex (F3, FC3, C3 in the international 10-20 EEG system), etc. The specific stimulation target can be selected according to the stimulation needs. The target object can be the object of transcranial magnetic stimulation. The electrocardiogram signal can be a bioelectric signal obtained by measuring the target object through an electrocardiogram device, which is used to record the electrical activity generated by each cardiac cycle of the heart.

[0029] Specifically, when performing transcranial magnetic stimulation, at least two stimulation targets can be selected in advance for the target object, and transcranial magnetic stimulation can be performed at each stimulation target position by the transcranial magnetic stimulator. Furthermore, the electrocardiogram signal during transcranial magnetic stimulation can be collected by the electrocardiogram device, and the collected electrocardiogram signal can be sent to the signal processing module 2 to process and analyze the electrocardiogram signal.

[0030] The signal processing module 2 is used to receive the ECG signal, process the ECG signal, obtain the R-peak detection signal, and send the R-peak detection signal to the target point determination module 3.

[0031] The R peak detection signal may be a signal that highlights the R wave in the electrocardiogram signal.

[0032] Specifically, the signal processing module 2 can obtain the ECG signal from the signal acquisition module 1, and remove the 50Hz power frequency interference, baseline drift, high and low frequency noise, etc. of the ECG signal to highlight the R wave in the ECG signal, so as to facilitate the subsequent detection of each R peak, so as to select from each stimulation target according to the R peak.

[0033] The target point determination module 3 is used to obtain the R peak detection signal and determine the target point from at least two stimulation target points for transcranial magnetic stimulation of the target object according to the R peak detection signal.

[0034] The target point may be a point among at least two stimulation points that is suitable for subsequent transcranial magnetic stimulation.

[0035] Specifically, the target determination module 3 can obtain the R peak detection signal from the signal processing module 2, and analyze the R peak detection signal to determine the stimulation target that can effectively reduce the heart rate of the target object as the target target.

[0036] The technical solution of the embodiment of the present invention obtains the electrocardiogram (ECG) signal of the target object when transcranial magnetic stimulation is performed on the target object through at least two stimulation target points through a signal acquisition module, receives the ECG signal based on the signal processing module, processes the ECG signal to obtain an R-peak detection signal, obtains the R-peak detection signal based on the target point determination module, and determines the target point from at least two stimulation target points for transcranial magnetic stimulation of the target object according to the R-peak detection signal, thereby solving the problem of inaccurate target point positioning during transcranial magnetic stimulation and achieving the technical effect of accurately determining the target point position according to the ECG signal.

[0037] Embodiment 2

[0038] Figure 2 This is a structural schematic diagram of a transcranial magnetic stimulation target determination system provided in Embodiment 2 of the present invention. Based on the above embodiment, the specific structures of the signal acquisition module 1, the signal processing module 2 and the target determination module 3 are explained.

[0039] like Figure 2 As shown, the signal processing module 1 is specifically used for: receiving an ECG signal, filtering the ECG signal based on a pre-designed notch filter, and obtaining an R peak detection signal corresponding to the ECG signal.

[0040] The notch filter may be a notch filter designed based on FIR (Finite Impulse Response, finite unit impulse response), that is, a low-pass filter and a high-pass filter are connected in series.

[0041] Specifically, a notch filter can be designed for the ECG signal to remove 50 Hz power frequency interference, baseline drift, and high and low frequency noise. The ECG signal is filtered by the notch filter, and the filtered ECG signal is determined as the R peak detection signal.

[0042] Optionally, the system also includes: a waveform correction module 4.

[0043] The waveform correction module 4 is connected to the signal processing module 2, and is used to obtain the R peak detection signal from the signal processing module 2, correct the waveform spacing of the R peak detection signal, and update the R peak detection signal based on the corrected signal.

[0044] Specifically, the ECG signal can be differentiated by the waveform correction module 4 so that the R wave peak difference forms a positive and negative extreme value pair. In the differential operation result, the positive and negative extreme values ​​with the largest modulus are found as the R wave threshold, that is, the R wave positive threshold and the R wave negative threshold. The R wave threshold is multiplied by a preset coefficient (for example, a coefficient of 0.5 determined according to statistical experiments) to obtain a new R wave threshold. The ECG signal is processed according to the R wave threshold, and the part greater than the R wave positive threshold is determined as a positive peak, and the part less than the R wave negative threshold is determined as a negative peak. The midpoint of the positions of adjacent positive and negative peaks is taken as the current R wave position point. Furthermore, according to the physiological characteristics of the QRS wave, the detected waveform spacing (i.e., RR spacing) is corrected to remove waveforms that are far less than the average value of the RR interval; for waveforms that are far greater than the spacing of the average value, the R wave threshold is lowered and re-detected to achieve the purpose of waveform correction of the R peak detection signal, and the R peak detection signal is updated.

[0045] Optionally, the signal acquisition module 1 includes: a stimulation intensity determination unit 11 , a transcranial magnetic stimulator 12 and an electrocardiograph 13 .

[0046] Among them, the stimulation intensity determination unit 11 is used to obtain the resting movement threshold of the target object, and determine the stimulation intensity of transcranial magnetic stimulation according to the resting movement threshold; the transcranial magnetic stimulator 12 is connected to the stimulation intensity determination unit 11, and is used to obtain the stimulation intensity, and based on the stimulation intensity, the preset stimulation duration, the preset stimulation interval and at least two stimulation targets, perform transcranial magnetic stimulation on the target object; the electrocardiograph 13 is used to measure and collect the electrocardiogram signal of the target object during transcranial magnetic stimulation.

[0047] The stimulation intensity determination unit 11 is used to obtain the resting motion threshold of the target object and determine the stimulation intensity of the transcranial magnetic stimulation according to the resting motion threshold.

[0048] The resting motor threshold may be the minimum stimulation intensity required for stimulating the motor cortex with transcranial magnetic stimulation to induce motor evoked potentials of the target muscle (usually the abductor pollicis brevis) with an amplitude exceeding 50 μV in at least 5 of 10 stimulations. The stimulation intensity may be the intensity used for subsequent transcranial magnetic stimulation.

[0049] Specifically, the resting motion threshold corresponding to the target object can be determined by measuring the resting motion threshold. Then, the resting motion threshold is multiplied by a preset multiple to obtain the stimulation intensity. Exemplarily, the stimulation intensity can be 110% of the resting motion threshold.

[0050] The transcranial magnetic stimulator 12 is used to obtain the stimulation intensity, and perform transcranial magnetic stimulation on the target object based on the stimulation intensity, the preset stimulation duration, the preset stimulation interval and at least two stimulation targets.

[0051] The preset stimulation duration may be the duration of continuous stimulation during transcranial magnetic stimulation, and the preset stimulation interval may be the time interval between two adjacent transcranial magnetic stimulations.

[0052] Specifically, the transcranial magnetic stimulator 12 can obtain the stimulation intensity determined by the stimulation intensity determination unit 11, and perform transcranial magnetic stimulation for a preset stimulation duration at each stimulation target point of the target object with the stimulation intensity, with a preset stimulation interval between every two transcranial magnetic stimulations.

[0053] The electrocardiograph 13 is used to measure and collect the electrocardiograph signal of the target object when the target object is undergoing transcranial magnetic stimulation.

[0054] Specifically, the electrocardiograph 13 can continuously measure the electrocardiograph signal of the target object, including the electrocardiograph signal of the target object when the target object is undergoing transcranial magnetic stimulation.

[0055] Optionally, the target point determination module 3 includes: a stimulation time period determination submodule 31 , an RR interval difference determination submodule 32 and a target point determination submodule 33 .

[0056] Among them, the stimulation time period determination submodule 31 is used to obtain at least two stimulation targets for transcranial magnetic stimulation of the target object and the stimulation time period corresponding to each stimulation target; the RR interval difference determination submodule 32 is connected to the stimulation time period determination submodule 31, and is used to obtain the stimulation time period corresponding to each stimulation target, and for each stimulation time period, determine the RR interval difference corresponding to the stimulation time period from the R peak detection signal; each stimulation target and the RR interval difference corresponding to each stimulation target are sent to the target target determination submodule 33; the target target determination submodule 33 is connected to the RR interval difference determination submodule 32, and is used to obtain each stimulation target and the RR interval difference corresponding to each stimulation target, determine the target difference according to each RR interval difference, and use the stimulation target corresponding to the target difference as the target target.

[0057] The stimulation time period determination submodule 31 is used to obtain at least two stimulation target points for performing transcranial magnetic stimulation on the target object and a stimulation time period corresponding to each stimulation target point.

[0058] Among them, the stimulation time period can be the time period for transcranial magnetic stimulation of any stimulation target. For example, for stimulation target A, if transcranial magnetic stimulation is performed at 0-5s, then 0-5s can be used as the stimulation time period corresponding to stimulation target A; if transcranial magnetic stimulation is performed at 0-5s and 30-35s, then 0-5s and 30-35s can be used as the stimulation time periods corresponding to stimulation target A.

[0059] Specifically, based on the stimulation time period submodule 31, the stimulation time period for transcranial magnetic stimulation can be obtained, that is, the time period for continuous stimulation at each stimulation target point.

[0060] The RR interval difference determination submodule 32 is used to obtain the stimulation time period corresponding to each stimulation target point, and for each stimulation time period, determine the RR interval difference corresponding to the stimulation time period from the R peak detection signal; and send each stimulation target point and the RR interval difference corresponding to each stimulation target point to the target point determination submodule 33.

[0061] The RR interval difference may be the difference between the maximum and minimum RR intervals during the stimulation period. The RR interval may be the interval between each heart beat, that is, the time interval between two heart beats may be obtained based on the distance between two R waves.

[0062] Specifically, the stimulation time period corresponding to each stimulation target point is determined, and each stimulation time period is processed separately. Therefore, one stimulation time period is taken as an example for explanation. Each RR interval in the stimulation time period is determined, and the difference between the maximum value and the minimum value in the determined RR interval is obtained as the RR interval difference. Furthermore, after the RR interval difference corresponding to each stimulation target point is determined, the stimulation target point and the RR interval difference are sent to the target point determination submodule 33.

[0063] The target point determination submodule 33 is connected to the RR interval difference determination submodule 32, and is used to obtain each stimulation target point and the RR interval difference corresponding to each stimulation target point, determine the target difference according to each RR interval difference, and use the stimulation target point corresponding to the target difference as the target target point.

[0064] The target difference may be the maximum value among the RR interval differences.

[0065] Specifically, the maximum value is determined from the obtained RR interval differences as the target difference, and then the stimulation target point corresponding to the target difference is used as the target target point for subsequent transcranial magnetic stimulation.

[0066] It should be noted that patients with depression have impaired autonomic nervous regulation, which is clinically manifested as higher heart rate and lower heart rate variability. The DLPFC and SGC (subgenual cingulate cortex) that are dysregulated in depression are connected to cardiac function through the vagus nerve (VN). Using the DLPFC-VN neural network, rTMS stimulation of the DLPFC can reduce the patient's heart rate. The stimulation site that most significantly reduces the heart rate is most closely connected to the DLPFC-VN neural network function, thereby determining the best stimulation target for rTMS treatment of depression.

[0067] Optionally, the RR interval difference determination submodule 32 includes: an RR interval determination unit 321 , an RR interval difference determination unit 322 and a sending unit 323 .

[0068] Among them, the RR interval determination unit 321 is used to obtain the R peak detection signal, and determine at least two maximum peaks corresponding to the R peak detection signal, and determine at least one RR interval and the time position corresponding to each RR interval based on the at least two maximum peaks; the RR interval difference determination unit 322 is connected to the RR interval determination unit 321, and is used to obtain the stimulation time period corresponding to each stimulation target point, for each stimulation time period, determine at least two time positions corresponding to the stimulation time period from each time position, and determine the RR interval difference corresponding to the stimulation time period based on the maximum RR interval and the minimum RR interval corresponding to the at least two time positions; the sending unit 323 is connected to the RR interval difference determination unit 322, and is used to obtain the RR interval difference corresponding to the stimulation time period, and send each RR interval difference to the target point determination submodule 33.

[0069] The RR interval determination unit 321 is used to obtain the R peak detection signal, determine at least two maximum peaks corresponding to the R peak detection signal, and determine at least one RR interval and a time position corresponding to each RR interval according to the at least two maximum peaks.

[0070] The maximum peak may be the maximum value of each R wave in the R peak detection signal, and the time position may be the time corresponding to the maximum peak.

[0071] Specifically, the RR interval determination unit 321 determines each maximum peak in the R peak detection signal based on the R peak detection signal, and determines the time position corresponding to each maximum peak.

[0072] The RR interval difference determination unit 322 is used to obtain the stimulation time period corresponding to each stimulation target point, and for each stimulation time period, determine at least two time positions corresponding to the stimulation time period from each time position, and determine the RR interval difference corresponding to the stimulation time period based on the maximum RR interval and the minimum RR interval corresponding to the at least two time positions.

[0073] The maximum RR interval may be the maximum value of the time difference values ​​determined by two adjacent time positions, and the minimum RR interval may be the minimum value of the time difference values ​​determined by two adjacent time positions.

[0074] Specifically, for each stimulation time period corresponding to each stimulation target point, each time position in the stimulation time period is determined, and the RR interval is determined according to any two adjacent time positions, and the maximum value among the RR intervals is determined as the maximum RR interval, and the minimum value among the RR intervals is determined as the minimum RR interval. Then, the difference between the maximum RR interval and the minimum RR interval is determined as the RR interval difference corresponding to the stimulation time period.

[0075] The sending unit 323 is used to obtain the RR interval difference corresponding to the stimulation time period, and send each RR interval difference to the target point determination submodule 33.

[0076] Optionally, the target point determination submodule 33 includes: a target difference determination unit 331 and a target point determination unit 332 .

[0077] Among them, the target difference determination unit 331 is used to obtain the RR interval difference corresponding to each stimulation target point, and determine the minimum value of each RR interval difference as the target difference; the target point determination unit 332 is connected to the target difference determination unit 331, and is used to obtain each stimulation target point and obtain the target difference, and determine the stimulation target point corresponding to the target difference as the target target point.

[0078] The target difference determination unit 331 is used to obtain the RR interval difference corresponding to each stimulation target point, and determine the minimum value among the RR interval differences as the target difference.

[0079] Specifically, the target difference determination unit 331 obtains the RR interval difference corresponding to each stimulation target point for each stimulation target point, and takes the minimum value of the RR interval difference corresponding to each stimulation target point as the target difference.

[0080] The target point determination unit 332 is used to obtain each stimulation target point and obtain the target difference value, and determine the stimulation target point corresponding to the target difference value as the target target point.

[0081] Specifically, the target point determination unit 332 is used to obtain and determine the stimulation target point corresponding to the target difference as the target target point.

[0082] Optionally, the system also includes: a signal synchronization module 5.

[0083] Among them, the signal synchronization module 5 is connected to the signal acquisition module 1 and the signal processing module 2, respectively, and is used to obtain the high-frequency trigger signal when performing transcranial magnetic stimulation on the target object, the electrocardiogram signal collected by the signal acquisition module, and the R-peak detection signal in the signal processing module, and synchronize the high-frequency trigger signal, the electrocardiogram signal and the R-peak detection signal according to the signal acquisition time.

[0084] Among them, the high-frequency trigger signal can be a trigger signal for transcranial magnetic stimulation, and the high-frequency trigger signal can be issued at a preset stimulation frequency and stimulation intensity, for example: the stimulation frequency is 10 Hz and the stimulation intensity is 110% of the resting motor threshold.

[0085] Specifically, a high-frequency trigger signal when performing transcranial magnetic stimulation on a target object, an electrocardiogram signal collected by a signal acquisition module, and an R-peak detection signal in a signal processing module are obtained, and the three signals are synchronized according to the signal acquisition time.

[0086] Optionally, the system also includes: a display module 6.

[0087] The display module 6 is connected to the signal synchronization module 5 and is used to obtain and display the synchronized high-frequency trigger signal, electrocardiogram signal and R-peak detection signal.

[0088] Specifically, the display module 6 can be a device such as a display screen for displaying various waveforms of multiple channels. The display module 6 can obtain the synchronized high-frequency trigger signal, electrocardiogram signal and R-peak detection signal from the signal synchronization module 5, and display these signals so that the experimenter can synchronously observe the waveforms of these three signals and make reasonable judgments on transcranial magnetic stimulation.

[0089] Figure 3 This is a schematic diagram of the structure of another transcranial magnetic stimulation target determination system provided by the second embodiment of the present invention. Figure 3 As shown, it includes: a transcranial magnetic stimulator, an electrocardiograph, a multi-channel acquisition card and a synchronous real-time display system (display module).

[0090] When the target of repeated transcranial magnetic stimulation of the target object is determined, the ECG signal of the target object is synchronously collected. Then, the ECG signal of the target object and the trigger sequence (high-frequency trigger signal) output by the transcranial magnetic stimulator are output to the multi-channel signal acquisition card respectively, and the ECG signal is converted into the RR interval and only the trough of the signal is taken and the respiratory signal (R peak detection signal) is filtered out. Furthermore, a programming language (such as: python / C++ mixed programming) can be used to build a TMS-ECG recording synchronous display system (synchronous real-time display system). Based on the ECG signal, trigger sequence and R peak detection signal synchronously displayed in the synchronous real-time display system, the degree of change of the ECG signal corresponding to each stimulation target (i.e., the R interval difference) can be quickly identified to determine the best rTMS treatment target (target target).

[0091] Exemplarily, the heart rate data (ECG signal) of the target object under repetitive transcranial magnetic stimulation with a stimulation frequency of 10 Hz, a stimulation intensity of 110%, a resting motor threshold (RMT), a stimulation duration of 5 s, and an interval of 25 s are collected. The left DLPFC of the target object is subjected to repetitive transcranial magnetic stimulation according to the 10-20 scalp EEG electrode positioning system. The ECG signal is filtered. Since the QRS signal has significant waveform characteristics, a notch filter is designed based on FIR, that is, a low-pass filter and a high-pass filter are connected in series, the purpose is to remove 50 Hz power frequency interference, baseline drift and high and low frequency noise. At the same time, the differential operation result of the waveform during filtering is retained, and the positive and negative extreme values ​​with the largest modulus multiplied by the coefficient 0.5 (statistical result) are found in the differential result as the threshold of R wave detection, and the maximum and minimum peaks are updated in real time, and the midpoint of the positive and negative peak positions is taken as the current R wave position point. According to the physiological characteristics of the waveform, the spacing of the detected waveform is corrected to remove the waveform that is much smaller than the average value; for the waveform that is much larger than the spacing average value, the threshold is lowered and then detected. The filtering results are displayed in real time. The waveform diagram of the target point determination method is as follows: Figure 4 As shown in the figure, the heart rate was recorded at three different locations (F3, FC3, C3) of the left DLPFC of the stimulation cortex, and each location lasted for 5 seconds. The y-axis represents the interval between two consecutive R peaks recorded by the electrocardiogram (RR interval). Figure 4 It can be seen that when the F3 target point is stimulated, the RR interval is prolonged (ie, the RR interval difference is the largest), and the heart rate of the target object is significantly reduced, so F3 can be determined as the treatment target (target target) of the target object.

[0092] It should be noted that the peak of the RR signal (such as: Figure 4 point a) and trough (such as: Figure 4Point b in the middle can reflect the heart rate regulation caused by breathing. The difference between the peak and trough of the RR signal (RR interval difference) can be used to limit the observation range of subsequent analysis, that is, to maximize the space for detecting RR deceleration, thereby effectively eliminating the influence of breathing.

[0093] The technical solution of the embodiment of the present invention obtains the electrocardiogram (ECG) signal of the target object when transcranial magnetic stimulation is performed on the target object through at least two stimulation target points through a signal acquisition module, receives the ECG signal based on the signal processing module, processes the ECG signal to obtain an R-peak detection signal, obtains the R-peak detection signal based on the target point determination module, and determines the target point from at least two stimulation target points for transcranial magnetic stimulation of the target object according to the R-peak detection signal, thereby solving the problem of inaccurate target point positioning during transcranial magnetic stimulation and achieving the technical effect of accurately determining the target point position according to the ECG signal.

[0094] Embodiment 3

[0095] Figure 5 This is a flow chart of a method for determining a transcranial magnetic stimulation target provided in Embodiment 3 of the present invention. This embodiment is applicable to the case of determining a transcranial magnetic stimulation target, and the method can be executed by a transcranial magnetic stimulation target determination system.

[0096] like Figure 5 As shown, the method of this embodiment specifically includes the following steps:

[0097] S510. Based on the signal acquisition module, an electrocardiogram signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points is obtained, and the electrocardiogram signal is sent to the signal processing module.

[0098] S520, based on the signal processing module, receiving the ECG signal, processing the ECG signal to obtain an R peak detection signal, and sending the R peak detection signal to the target determination module.

[0099] S530: Based on the target point determination module, an R peak detection signal is obtained, and according to the R peak detection signal, a target point is determined from at least two stimulation target points for transcranial magnetic stimulation of the target object.

[0100] Optionally, based on a signal processing module, the ECG signal is received, and based on a pre-designed notch filter, the ECG signal is filtered to obtain an R peak detection signal corresponding to the ECG signal.

[0101] Optionally, the system further includes a waveform correction module; based on the waveform correction module, the R-peak detection signal is obtained from the signal processing module, and the waveform spacing of the R-peak detection signal is corrected, and the R-peak detection signal is updated based on the corrected signal.

[0102] Optionally, the target determination module includes: a stimulation time period determination submodule, an RR interval difference determination submodule and a target target determination submodule; based on the stimulation time period determination submodule, at least two stimulation targets for transcranial magnetic stimulation of the target object and the stimulation time period corresponding to each stimulation target are obtained; based on the RR interval difference determination submodule, the stimulation time period corresponding to each stimulation target is obtained, and for each stimulation time period, the RR interval difference corresponding to the stimulation time period is determined from the R peak detection signal; each stimulation target and the RR interval difference corresponding to each stimulation target are sent to the target target determination submodule; based on the target target determination submodule, each stimulation target and the RR interval difference corresponding to each stimulation target are obtained, and the target difference is determined according to each RR interval difference, and the stimulation target corresponding to the target difference is used as the target target.

[0103] Optionally, the RR interval difference determination submodule includes: an RR interval determination unit, an RR interval difference determination unit and a sending unit; based on the RR interval determination unit, the R peak detection signal is obtained, and at least two maximum peaks corresponding to the R peak detection signal are determined, and at least one RR interval and the time position corresponding to each RR interval are determined according to the at least two maximum peaks; based on the RR interval difference determination unit, a stimulation time period corresponding to each stimulation target is obtained, and for each stimulation time period, at least two time positions corresponding to the stimulation time period are determined from each time position, and the RR interval difference corresponding to the stimulation time period is determined according to the maximum RR interval and the minimum RR interval corresponding to the at least two time positions; based on the sending unit, the RR interval difference corresponding to the stimulation time period is obtained, and each RR interval difference is sent to the target point determination submodule.

[0104] Optionally, the target point determination submodule includes: a target difference determination unit and a target point determination unit; based on the target difference determination unit, the RR interval difference corresponding to each stimulation target point is obtained, and the minimum value of each RR interval difference is determined as the target difference; based on the target point determination unit, each stimulation target point is obtained, and the target difference is obtained, and the stimulation target point corresponding to the target difference is determined as the target target point.

[0105] Optionally, the signal acquisition module includes: a stimulation intensity determination unit, a transcranial magnetic stimulator and an electrocardiograph; based on the stimulation intensity determination unit, the resting motion threshold of the target object is obtained, and the stimulation intensity of the transcranial magnetic stimulation is determined according to the resting motion threshold; based on the transcranial magnetic stimulator, the stimulation intensity is obtained, and based on the stimulation intensity, a preset stimulation duration, a preset stimulation interval and at least two stimulation targets, transcranial magnetic stimulation is performed on the target object; based on the electrocardiograph, the electrocardiogram signal of the target object during transcranial magnetic stimulation is measured and acquired.

[0106] Optionally, the system also includes: a signal synchronization module; based on the signal synchronization module, a high-frequency trigger signal when transcranial magnetic stimulation is performed on the target object, the electrocardiogram signal collected by the signal acquisition module, and an R-peak detection signal in the signal processing module are obtained, and the high-frequency trigger signal, the electrocardiogram signal and the R-peak detection signal are synchronized according to the signal acquisition time.

[0107] Optionally, the system further includes: a display module; based on the display module, acquiring and displaying the synchronized high-frequency trigger signal, the electrocardiogram signal and the R-peak detection signal.

[0108] The technical solution of the embodiment of the present invention obtains the electrocardiogram (ECG) signal of the target object when transcranial magnetic stimulation is performed on the target object through at least two stimulation target points through a signal acquisition module, receives the ECG signal based on the signal processing module, processes the ECG signal to obtain an R-peak detection signal, obtains the R-peak detection signal based on the target point determination module, and determines the target point from at least two stimulation target points for transcranial magnetic stimulation of the target object according to the R-peak detection signal, thereby solving the problem of inaccurate target point positioning during transcranial magnetic stimulation and achieving the technical effect of accurately determining the target point position according to the ECG signal.

[0109] It should be understood that the various forms of processes shown above can be used to reorder, add or delete steps. For example, the steps described in the present invention can be executed in parallel, sequentially or in different orders, as long as the desired results of the technical solution of the present invention can be achieved, and this document does not limit this.

[0110] The above specific implementations do not constitute a limitation on the protection scope of the present invention. It should be understood by those skilled in the art that various modifications, combinations, sub-combinations and substitutions can be made according to design requirements and other factors. Any modification, equivalent substitution and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A transcranial magnetic stimulation target determination system, characterized in that: include: Signal acquisition module, signal processing module and target determination module; wherein, The signal acquisition module is used to acquire the electrocardiogram signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points, and send the electrocardiogram signal to the signal processing module; The signal processing module is connected to the signal acquisition module, and is used to receive the ECG signal, process the ECG signal, obtain an R-peak detection signal, and send the R-peak detection signal to the target point determination module; The target point determination module is connected to the signal processing module and is used to obtain the R peak detection signal and determine a target point from at least two stimulation target points for transcranial magnetic stimulation of the target object according to the R peak detection signal; The target point determination module includes: a stimulation time period determination submodule, an RR interval difference determination submodule and a target point determination submodule; wherein, The stimulation time period determination submodule is used to obtain at least two stimulation target points for transcranial magnetic stimulation of the target object and a stimulation time period corresponding to each stimulation target point; The RR interval difference determination submodule is connected to the stimulation time period determination submodule, and is used to obtain the stimulation time period corresponding to each stimulation target point, and for each stimulation time period, determine the RR interval difference corresponding to the stimulation time period from the R peak detection signal; and send each stimulation target point and the RR interval difference corresponding to each stimulation target point to the target point determination submodule; The target target point determination submodule is connected to the RR interval difference determination submodule, and is used to obtain each stimulation target point and the RR interval difference corresponding to each stimulation target point, determine the target difference according to each RR interval difference, and use the stimulation target point corresponding to the target difference as the target target point.

2. The system according to claim 1, characterized in that The signal processing module is specifically used for: The electrocardiogram signal is received, and based on a pre-designed notch filter, the electrocardiogram signal is filtered to obtain an R peak detection signal corresponding to the electrocardiogram signal.

3. The system according to claim 2, characterized in that Also includes: Waveform correction module, where: The waveform correction module is connected to the signal processing module, and is used to obtain the R-peak detection signal from the signal processing module, correct the waveform spacing of the R-peak detection signal, and update the R-peak detection signal based on the corrected signal.

4. The system according to claim 1, characterized in that The RR interval difference determination submodule includes: an RR interval determination unit, an RR interval difference determination unit and a sending unit; wherein, The RR interval determination unit is used to obtain the R peak detection signal, determine at least two maximum peaks corresponding to the R peak detection signal, and determine at least one RR interval and a time position corresponding to each RR interval according to the at least two maximum peaks; The RR interval difference determination unit is connected to the RR interval determination unit, and is used to obtain a stimulation time period corresponding to each stimulation target point, determine at least two time positions corresponding to the stimulation time period from each time position for each stimulation time period, and determine the RR interval difference corresponding to the stimulation time period according to the maximum RR interval and the minimum RR interval corresponding to the at least two time positions; The sending unit is connected to the RR interval difference determination unit, and is used to obtain the RR interval difference corresponding to the stimulation time period, and send each RR interval difference to the target point determination submodule.

5. The system according to claim 1, characterized in that: The target point determination submodule includes: a target difference determination unit and a target point determination unit; wherein, The target difference determination unit is used to obtain the RR interval difference corresponding to each stimulation target point, and determine the minimum value among the RR interval differences as the target difference; The target point determination unit is connected to the target difference determination unit, and is used to obtain the stimulation target points and the target difference, and determine the stimulation target point corresponding to the target difference as the target target point.

6. The system according to claim 1, characterized in that: The signal acquisition module includes: a stimulation intensity determination unit, a transcranial magnetic stimulator and an electrocardiograph; wherein, The stimulation intensity determination unit is used to obtain the resting motion threshold of the target object and determine the stimulation intensity of the transcranial magnetic stimulation according to the resting motion threshold; The transcranial magnetic stimulator is connected to the stimulation intensity determination unit, and is used to obtain the stimulation intensity, and perform transcranial magnetic stimulation on the target object based on the stimulation intensity, the preset stimulation duration, the preset stimulation interval, and at least two stimulation targets; The electrocardiograph is used to measure and collect the electrocardiograph signal of the target object when the target object is undergoing transcranial magnetic stimulation.

7. The system according to claim 1, characterized in that Also includes: Signal synchronization module; wherein, The signal synchronization module is connected to the signal acquisition module and the signal processing module respectively, and is used to obtain the high-frequency trigger signal when transcranial magnetic stimulation is performed on the target object, the electrocardiogram signal collected by the signal acquisition module, and the R-peak detection signal in the signal processing module, and synchronize the high-frequency trigger signal, the electrocardiogram signal, and the R-peak detection signal according to the signal acquisition time.

8. The system according to claim 7, characterized in that Also includes: Display module; wherein, The display module is connected to the signal synchronization module, and is used to acquire and display the synchronized high-frequency trigger signal, the electrocardiogram signal and the R-peak detection signal.

9. A method for determining a transcranial magnetic stimulation target, characterized in that: include: Based on the signal acquisition module, an electrocardiogram signal of the target object is obtained when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points, and the electrocardiogram signal is sent to the signal processing module; Based on the signal processing module, the electrocardiogram signal is received, the electrocardiogram signal is processed to obtain an R peak detection signal, and the R peak detection signal is sent to the target point determination module; Based on the target point determination module, the R peak detection signal is acquired, and according to the R peak detection signal, a target point is determined from at least two stimulation target points for transcranial magnetic stimulation of the target object; The target point determination module includes: a stimulation time period determination submodule, an RR interval difference determination submodule and a target point determination submodule; wherein, Based on the stimulation time period determination submodule, obtaining at least two stimulation target points for transcranial magnetic stimulation of the target object and a stimulation time period corresponding to each stimulation target point; The RR interval difference determination submodule is connected to the stimulation time period determination submodule, and based on the RR interval difference determination submodule, the stimulation time period corresponding to each stimulation target point is obtained, and for each stimulation time period, the RR interval difference corresponding to the stimulation time period is determined from the R peak detection signal; each stimulation target point and the RR interval difference corresponding to each stimulation target point are sent to the target point determination submodule; The target target point determination submodule is connected to the RR interval difference determination submodule. Based on the target target point determination submodule, each stimulation target point and the RR interval difference corresponding to each stimulation target point are obtained, and the target difference is determined according to each RR interval difference, and the stimulation target point corresponding to the target difference is used as the target target point.

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