A hangover-relieving composition, preparation method and application thereof

Abstract

The present invention relates to the technical field of traditional Chinese medicine, and in particular to a hangover-relieving composition, a preparation method thereof, and an application thereof. The hangover-relieving composition comprises the following raw materials in proportion by weight: 3-18 parts of corn peptide powder, 1-8 parts of Sophora japonica flower, 1-9 parts of Taraxacum mongolicum, 1-6 parts of Licorice root, 1-5 parts of Rhizoma Alismatis, 2-10 parts of Elsholtzia ciliata, 1-6 parts of Citrus aurantium, 1-5 parts of Scutellaria baicalensis, 1-6 parts of Radix Bupleuri, 0.5-4.5 parts of Citron, 1-3.5 parts of Folium Perillae, 1-4.5 parts of Patchouli, and 11-23 parts of concentrated fruit and vegetable juice. The hangover-relieving composition obtained by the preparation method of the present invention can not only promote the decomposition of acetaldehyde decomposed from ethanol into carbon dioxide and water, but also increase the amount of acetaldehyde dehydrogenase in the body during and after drinking, quickly relieve alcohol, avoid damage to the liver and stomach due to the action of acetaldehyde, avoid acute and chronic toxicity of alcohol to the human body, and also play the effects of detoxification, lipid-lowering, stomach-strengthening, brain-protecting, anti-vomiting, and heat-relieving.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a hangover-relieving composition, a preparation method and an application thereof. Background Art

[0002] Alcohol has always played a significant role in consumption worldwide, and its relationship with health has become a topic of great concern. Moderate drinking can help lower blood pressure, protect myocardial tissue, and reduce the incidence of arteriosclerosis. However, continued excessive drinking is harmful to health. Alcohol has direct effects on body tissues and organs, with the liver and stomach being the most affected. Approximately 20% of alcohol consumed is absorbed in the stomach, while 80% is absorbed in the duodenum and small intestine. Only a very small amount is excreted directly through the kidneys through the urethra, through the lungs through the respiratory tract, or through sweat glands. A small amount of alcohol in the digestive tract mucosa is converted to acetaldehyde by alcohol dehydrogenase. The majority of alcohol enters the liver, where it is converted to acetaldehyde by alcohol dehydrogenase and P450 enzymes. This acetaldehyde is oxidized by acetaldehyde dehydrogenase and liver P450 enzymes to produce acetic acid, which is then metabolized into carbon dioxide and water. Alcohol metabolism occurs primarily in the liver and stomach, primarily by alcohol dehydrogenase and acetaldehyde dehydrogenase. The lack of acetaldehyde dehydrogenase means that alcohol cannot be completely broken down into water and carbon dioxide, but continues to remain in the body in the form of acetaldehyde. Acetaldehyde will stimulate the secretion of adrenaline, norepinephrine, etc., causing the drinker to flush his face, accelerate his heartbeat, etc., and acetaldehyde has direct neurotoxicity, cardiotoxicity and liver toxicity. Therefore, excessive drinkers have symptoms of acute and chronic alcohol poisoning and show neurological abnormalities, and may even suffer from coma or shock.

[0003] At present, there are many studies on the rescue of alcohol poisoning at home and abroad. However, most of the existing Chinese herbal medicines need to be taken after drinking for a period of time when the ethanol in the body is broken down into acetaldehyde before they can take effect. Taking the medicine at this time not only takes a long time to take effect, but the acetaldehyde has already had a toxic effect on the human body. Summary of the Invention

[0004] In view of this, the present invention provides a hangover-relieving composition, a preparation method and application thereof. The hangover-relieving composition obtained by the preparation method of the present invention can not only promote the decomposition of acetaldehyde generated by ethanol into carbon dioxide and water, but also increase the amount of acetaldehyde dehydrogenase in the body during and after drinking, quickly relieve alcohol, avoid damage to the human liver and stomach due to the action of acetaldehyde, avoid acute and chronic toxicity of alcohol to the human body, and can also exert the effects of detoxification, lipid-lowering, stomach-strengthening, brain protection, anti-vomiting and heat relief, thereby overcoming the defects of the prior art.

[0005] In order to achieve the above-mentioned object of the invention, the present invention adopts the following technical solutions:

[0006] The first aspect of the present invention provides a hangover-relieving composition, comprising the following raw materials in proportions by weight: 3-18 parts of corn peptide powder, 1-8 parts of Sophora japonica flowers, 1-9 parts of dandelions, 1-6 parts of licorice, 1-5 parts of Alisma orientalis, 2-10 parts of Elsholtzia ciliata, 1-6 parts of Citrus aurantium, 1-5 parts of Scutellaria baicalensis, 1-6 parts of Bupleurum chinense, 0.5-4.5 parts of Citron, 1-3.5 parts of Perilla frutescens, 1-4.5 parts of Patchouli and 11-23 parts of concentrated fruit and vegetable juice.

[0007] The composition of the present invention combines the ideas of Chinese and Western medicine, and has a reasonable formula and compatibility. It is in line with the traditional theory and experience of Chinese medicine and prescriptions that attach importance to the efficacy of comprehensive ingredients, and is in line with the emphasis on monomer effective ingredients in Western medicine. By combining various medicinal materials in a reasonable monarch-minister-assistant-adjuvant relationship, it can not only promote the rapid decomposition of acetaldehyde decomposed from ethanol into carbon dioxide and water, thereby achieving hangover relief, but also increase the amount of acetaldehyde dehydrogenase in the body during and after drinking, promote alcohol metabolism, quickly relieve alcohol, inhibit gastrointestinal absorption of alcohol, form a protective film on the liver and stomach, avoid damage to the liver and stomach of the human body due to the action of acetaldehyde, and avoid alcohol poisoning. The hangover relief composition provided by the present invention has good therapeutic effects in long-term liver and stomach protection, brain protection, detoxification, lipid reduction, vomiting and heat relief, and overcomes the defects of the prior art.

[0008] Among the various Chinese herbs in the above formula:

[0009] Sophora japonica flowers are bitter and slightly cool in nature; they clear away heat and fire, relieve alcohol, and are anti-inflammatory.

[0010] Dandelion tastes bitter and sweet, and is cold in nature; it clears away heat and detoxifies, reduces swelling and resolves stagnation, and promotes dampness and relieves stranguria.

[0011] Licorice is sweet and neutral in nature; it clears away heat and detoxifies, moistens the lungs and relieves coughs, and harmonizes various medicines;

[0012] Alisma is sweet in taste and cold in nature; it can dissipate water and dampness, dissipate heat and relieve stranguria;

[0013] Elsholtzia ciliata tastes pungent and is warm in nature; it can induce sweating, relieve exterior symptoms, and soothe the middle and eliminate dampness.

[0014] Huajuhong tastes spicy and bitter, and is warm in nature; it can eliminate phlegm, regulate qi, strengthen the stomach, and help digestion;

[0015] Scutellaria root is bitter in taste and cold in nature; it can relieve excess fire, eliminate dampness and heat, and stop bleeding;

[0016] Bupleurum is bitter in taste and cool in nature; it harmonizes the exterior and interior, soothes the liver, and raises yang.

[0017] Citron tastes pungent, sour, and bitter, and is warm in nature; it regulates qi and relieves adverse reactions, relieves chest tightness, and resolves phlegm.

[0018] Perilla leaves are pungent and warm in nature; they can dispel cold, promote qi circulation and soothe the stomach;

[0019] Patchouli is pungent and warm in nature; it can relieve qi, harmonize the stomach, dispel filth and eliminate dampness.

[0020] In the hangover-relieving composition of the present invention, corn peptide is the main drug that relieves alcohol, protects the liver, has antioxidant effects, lowers blood pressure, inhibits angiotensin-converting enzyme activity, promotes alcohol metabolism, and inhibits gastrointestinal absorption of alcohol. Corn peptide, as a small molecule peptide, is easily digested and absorbed, does not require secondary gastrointestinal digestion, and is directly absorbed by the small intestine. It can quickly exert its effects at the tissue level. In addition, corn peptide also has a preventive effect on alcoholic brain damage and can improve cell and synaptic dysfunction caused by disorders of some related neurotransmitters in brain tissue after alcohol consumption.

[0021] Sophora japonica flower, dandelion, Elsholtzia ciliata, dried orange peel, Scutellaria baicalensis and Bupleurum chinense are all ministerial herbs, assisting the monarch herbs to enhance the effects of hangover relief, liver and brain protection; among them, Sophora japonica flower clears away heat and fire, relieves hangover and is anti-inflammatory; Dandelion clears heat and detoxifies, reduces swelling and resolves stagnation, and promotes dampness and urination; Elsholtzia ciliata is anti-inflammatory, analgesic, antibacterial, antiviral, anti-aging and anti-cancer; the flavonoids in aromatherapy have antioxidant effects, which have a certain inhibitory effect on lipid peroxidation caused by ischemic brain damage, and can also scavenge free radicals in large quantities by increasing the activity of antioxidant enzymes, thus having anti-cancer and anti-tumor effects; dried orange peel dries dampness and resolves phlegm, helps digestion and resolves accumulation, eliminates phlegm and relieves cough, can increase the content of alcohol dehydrogenase in the liver, thereby achieving the effect of hangover relief, and can also form a protective film on the liver and stomach to prevent damage to the liver and stomach due to the stimulation of acetaldehyde; Scutellaria baicalensis and Bupleurum chinense are good at relieving dampness and heat in the body and can evacuate qi stagnation in the liver and gallbladder;

[0022] Licorice, Alisma, Citron, Perilla Leaf and Patchouli are all adjuvants. On the one hand, they serve as adjuvants to treat secondary symptoms, such as abdominal distension, nausea, vomiting, and liver qi stagnation; on the other hand, they serve as adjuvants to eliminate or reduce the toxicity or potency of the main and auxiliary drugs, and to harmonize the medicinal properties. They can assist the main and auxiliary drugs in nourishing the liver and stomach while harmonizing the medicinal properties of the main and auxiliary drugs to balance the yin and yang of the two, avoiding side effects on the human body when taken. Among them, Licorice nourishes the spleen and replenishes qi, clears away heat and detoxifies, eliminates phlegm and relieves cough, relieves urgency and relieves pain, harmonizes various drugs, and alleviates the toxicity and potency of drugs; Alisma promotes diuresis and eliminates dampness, relieves heat, resolves turbidity and lowers lipids; Citron soothes the liver and regulates qi, relieves fullness, and resolves phlegm; Perilla Leaf relieves exterior symptoms and dispels cold, promotes qi and harmonizes the stomach; Patchouli is aromatic and clears turbidity, harmonizes the middle and stops vomiting, and relieves heat.

[0023] Concentrated fruit and vegetable juices can improve taste and help sober up. They contain plant polyphenols, along with a variety of organic acids, vitamins, and nutrients. These can significantly increase the activity of alcohol dehydrogenase and acetaldehyde dehydrogenase, accelerating alcohol metabolism and breaking down acetaldehyde produced in the body, accelerating its conversion into acetic acid, carbon dioxide, and water, which is ultimately excreted. This reduces or eliminates the damage caused by acetaldehyde and alleviates adverse reactions such as dizziness, nausea, and vomiting. The plant polyphenols in fruit and vegetable juices can also alleviate alcoholic liver damage and have a strong liver-protecting effect. Their mechanism of action includes activating the body's antioxidant system, inhibiting lipid peroxidation, and regulating signaling pathways, thereby improving liver damage. Concentrated fruit and vegetable juices are preferably puree concentrates made from a blend of one or two of blueberries, apples, grapes, tomatoes, bananas, watermelons, grapefruits, or pears.

[0024] In combination with the first aspect, the hangover-relieving composition includes the following raw materials in the following weight ratios: 3-16 parts of corn peptide powder, 1-4 parts of Sophora japonica flowers, 1-2 parts of dandelions, 1-2 parts of licorice, 1-2 parts of Alisma orientalis, 2-3 parts of Elsholtzia ciliata, 1-2 parts of Citrus aurantium, 1-2 parts of Scutellaria baicalensis, 1-2 parts of Bupleurum chinense, 1-2 parts of Citron, 1-2 parts of Perilla frutescens, 1-2 parts of Patchouli and 13-20 parts of concentrated fruit and vegetable juice.

[0025] In combination with the first aspect, the hangover-relieving composition includes the following raw materials in the following weight ratios: 10 parts of corn peptide powder, 1 part of Sophora japonica flower, 1.5 parts of dandelion, 1.2 parts of licorice, 1 part of Alisma orientale, 2.5 parts of Elsholtzia ciliata, 1.2 parts of Citrus aurantium, 1.5 parts of Scutellaria baicalensis, 2 parts of Bupleurum chinense, 1.5 parts of Citron, 1 part of Perilla leaf, 1 part of Patchouli grandiflora and 15 parts of concentrated fruit and vegetable juice.

[0026] In combination with the first aspect, the hangover relieving composition may further include the following raw materials in proportions by weight: 0.05-1.5 parts of glutathione, 0.05-2 parts of vitamin C, and 0.1-1.5 parts of vitamin B.

[0027] Among the various ingredients in the above formula:

[0028] Glutathione is composed of glutamic acid, cysteine, and glycine, and contains sulfur groups. It is widely distributed in various organs of the body and plays an important role in maintaining cellular biological functions. It can activate multiple enzymes, thereby promoting the metabolism of sugar, fat, and protein, and can affect the metabolic process of cells. It can combine with free radicals in the body through sulfur groups and convert them into easily metabolizable acids, thereby accelerating the excretion of free radicals. It can also protect the liver's synthesis, detoxification, and hormone inactivation functions, promote bile acid metabolism, and facilitate the digestive tract's absorption of fat and fat-soluble vitamins.

[0029] Vitamin C has a strong reducing property, which can prevent the composition from being oxidized when it is placed for a long time and in contact with air. It also has certain detoxification and cancer prevention effects.

[0030] Vitamin B can promote alcohol metabolism.

[0031] When the hangover-relieving composition of the present invention contains the above components, glutathione and Sophora japonica flowers used together have a fat-removing effect on the liver infiltrated with fat; vitamin C and vitamin B can provide the required energy for the hangover-relieving process, supplement the vitamins required by the human body, and have a small auxiliary effect; the above composition can provide material energy for hangover-relieving, accelerate the hangover-relieving process, and avoid the acute and chronic toxicity of alcohol to the human body.

[0032] In combination with the first aspect, the hangover relieving composition may further include the following raw materials in proportions by weight: 0.05-0.2 parts of glutathione, 0.05-0.2 parts of vitamin C, and 0.1-0.3 parts of vitamin B.

[0033] In combination with the first aspect, the hangover relieving composition may further include the following raw materials in proportions by weight: 0.2 parts of glutathione, 0.1 parts of vitamin C, and 0.2 parts of vitamin B.

[0034] Optionally, 1 to 8 parts of sucrose can be added to the rescue composition. Sucrose is sweet and odorless, easily soluble in water and glycerin, and can increase the sweetness of the composition, enhance the mouthfeel of the composition, and thus improve the patient's experience. The amount of sucrose is more preferably 1 to 3 parts, and 2 parts is optional.

[0035] The second aspect of the present invention provides a preparation method of a hangover-relieving composition, which comprises at least the following steps: weighing each raw material according to the raw material ratio of the above-mentioned composition, crushing Sophora japonica flower, dandelion, licorice, Alisma orientalis, Elsholtzia ciliata, Citrus aurantium, Scutellaria baicalensis, Bupleurum chinense, Citron, Perilla leaf and Patchouli sinensis respectively, extracting with an extraction solvent, filtering, concentrating, and uniformly mixing with the remaining raw materials to obtain the composition.

[0036] This preparation method is simple to operate. The active ingredients of the composition are extracted and then concentrated, reducing the volume and increasing the concentration of the beneficial components of the traditional Chinese medicine. Concentrated fruit and vegetable juice, corn oligopeptides, glutathione, vitamin C, and vitamin B are added after concentration, preventing chemical composition damage or mutation during the extraction process, which could lead to loss of efficacy and nutritional value. The resulting product can be taken orally directly or further concentrated or diluted as needed in actual clinical applications.

[0037] In combination with the second aspect, the above extraction is a semi-bionic extraction, in which Sophora japonica flower, dandelion, licorice, Alisma orientale, Elsholtzia ciliata, Citrus aurantium, Scutellaria baicalensis, Bupleurum chinense, Citron, Perilla leaf and Patchouli are crushed separately and added with extraction solvent, heated and mixed at 80-100°C under normal pressure, decocted three times, and reflux extracted.

[0038] Semi-bionic extraction combines holistic and molecular drug research approaches from a biopharmaceutics perspective, simulating the gastrointestinal transport and absorption environment of oral drugs and employing an activity-guided, guided separation approach. This semi-bionic extraction method extracts the active ingredients from the composition to the maximum extent possible, maintaining the unique therapeutic efficacy of the original formula.

[0039] When the semi-bionic extraction method is used for the first decoction, the extraction solvent is a hydrochloric acid aqueous solution with a pH value of 2.0-2.5, the mass of the extraction solvent is 10 times the total mass of the medicinal materials, and the extraction time is 2 to 3.5 hours. When the semi-bionic extraction method is used for the first decoction, the extraction solvent is a sodium hydroxide aqueous solution with a pH value of 7.2-7.5, the mass of the extraction solvent is 8 times the total mass of the medicinal materials, and the extraction time is 80 to 100 minutes. When the semi-bionic extraction method is used for the third decoction, the extraction solvent is a sodium hydroxide aqueous solution with a pH value of 8.0-8.5, the mass of the extraction solvent is 6 times the total mass of the medicinal materials, and the extraction time is 40 to 60 minutes.

[0040] In combination with the second aspect, the concentration temperature is 65-80°C.

[0041] The third aspect of the present invention provides the use of the above-mentioned hangover-resolving composition in hangover-resolving medicines.

[0042] The application form of the hangover-relieving composition is that the solid preparation can be granules, tablets, capsules, pills or powders; the dissolving medium in the liquid preparation can be buffer solution, physiological saline or drinking water.

[0043] The hangover-relieving composition is taken during or after drinking, once a day, with 15 g of the hangover-relieving composition taken orally for every 60 kg of body weight (calculated as crude drug) to achieve the effect of rapid hangover relief. The hangover-relieving composition has the effects of protecting the liver and nourishing the stomach, preventing acute and chronic toxicity of alcohol to the human body, and can also exert the effects of detoxification, lowering blood lipids, strengthening the stomach, protecting the brain, stopping vomiting, and relieving heat. DETAILED DESCRIPTION

[0044] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0045] Most drugs containing traditional Chinese medicine ingredients need to drink alcohol for a period of time before they can take effect when the ethanol in the body is broken down into acetaldehyde. Taking these drugs not only takes a long time to take effect, but also inevitably causes acetaldehyde to be toxic to the human body. To solve this problem, the embodiments of the present invention provide a hangover-relieving composition and a preparation method thereof.

[0046] The hangover-relieving composition comprises the following raw materials in proportion by weight: 3-18 parts of corn peptide powder, 1-8 parts of sophora japonica flowers, 1-9 parts of dandelions, 1-6 parts of liquorice, 1-5 parts of oriental rhizome, 2-10 parts of elsholtzia ciliata, 1-6 parts of tangerine peel, 1-5 parts of scutellaria baicalensis, 1-6 parts of bupleurum root, 0.5-4.5 parts of citron, 1-3.5 parts of perilla leaves, 1-4.5 parts of patches of agave and 11-23 parts of concentrated fruit and vegetable juice.

[0047] In the schemes shown in the examples of the present invention, corn peptides serve as the main active ingredient. As the primary active substance, corn peptides have biological functions such as promoting alcohol metabolism, sobering up, protecting the liver, combating fatigue, promoting fat metabolism, providing antioxidant effects, inhibiting angiotensin-converting enzyme activity, lowering blood pressure, and preventing hepatic encephalopathy. Corn peptides can activate gastric mucosal ADH, enhancing first-pass ethanol metabolism in the gastrointestinal tract and inhibiting gastrointestinal absorption of alcohol. Corn peptides can also activate hepatic ADH, enhancing alcohol metabolism. Furthermore, corn peptides have a preventive effect on alcoholic brain damage, improving cellular and synaptic dysfunction caused by disturbances in some related neurotransmitters in brain tissue after alcohol consumption. Corn peptides are typically composed of 2 to 20 amino acids with a relative molecular mass between 300 and 1000 Da. As small-molecule peptides, corn peptides are easily digested and absorbed, eliminating the need for secondary gastrointestinal digestion and entering the small intestine for absorption, allowing them to rapidly exert their effects at the tissue level.

[0048] Sophora japonica flower, dandelion, Elsholtzia ciliata, Citrus aurantium, Scutellaria baicalensis and Bupleurum chinense are all assistant herbs, assisting the main herbs to strengthen the effects of hangover relief, liver protection and brain protection. Among them, Sophora japonica is cool in nature and has the effects of clearing away heat and detoxifying, relieving alcohol, anti-inflammatory, anti-tumor, lowering blood lipids, and maintaining capillary resistance; Taraxacum officinale is bitter and sweet in taste and cold in nature, and enters the liver and stomach meridians. It has the effects of clearing away heat and detoxifying, reducing swelling and dispersing stagnation, promoting dampness and relieving stranguria, and is mainly used to treat carbuncle, breast abscess, internal abscess, hot stranguria and painful stranguria, damp-heat jaundice, clearing the liver and improving eyesight; Elsholtzia ciliata is slightly warm and has the same function as medicine and food. It has the effects of anti-inflammatory, analgesic, antibacterial, antiviral, anti-aging, and anticancer, and can relieve alcohol and protect the brain. The flavonoids in aromatherapy are a class of reducing compounds with phenolic hydroxyl groups, which have little toxic side effects on the human body, have antioxidant effects, and have a certain inhibitory effect on lipid peroxidation caused by ischemic brain damage. It can also increase the activity of antioxidant enzymes, scavenge free radicals in large quantities, eliminate the carcinogenic effects of carcinogens, induce tumor cycle arrest, and thus promote the apoptosis of tumor cells. Huajuhong is pungent and bitter in nature, and enters the lung and spleen meridians. It has the effects of drying dampness and resolving phlegm, digesting food and resolving accumulation, and removing phlegm and relieving cough. It is mainly used to treat wind-cold cough, asthma with excessive phlegm, chest tightness, food accumulation, vomiting, and belching; Huajuhong can increase the content of alcohol dehydrogenase in the liver, thereby achieving the effect of sobering up, and can also form a protective film on the stomach and liver, thereby avoiding the irritation of alcohol to the liver and stomach; Huajuhong can be used to treat symptoms of cough and excessive phlegm caused by lung dryness. This medicinal material also has the effect of regulating qi and relieving fullness, and can also relieve nausea, vomiting, dizziness, headache, and loss of appetite; the active ingredients of Huajuhong, limonene and pinene, can make respiratory secretions more and thinner, which is conducive to the discharge of phlegm, and has good expectorant and antitussive effects. It is an excellent product for treating chronic cough and asthma in the elderly and phlegm and asthma due to deficiency and cold; the limonene contained in Huajuhong can promote the secretion of digestive juices and eliminate intestinal gas, and has a good effect on gastrointestinal stagnation. Taking it after meals can relieve digestive pressure in the stomach. Doctors of all dynasties believed that alcohol is a damp-heat and toxic evil. Drinking too much will cause illness. The heat and dampness of alcohol will accumulate in the body, which can lead to liver and stomach disharmony, qi stagnation and other alcohol-related symptoms. The Scutellaria baicalensis in the present invention has a bitter taste and is cold in nature. It can clear away heat and dampness, purge fire and detoxify. The Bupleurum chinense has a bitter and pungent taste and is slightly cold. It can relieve exterior symptoms and reduce fever, soothe the liver and relieve depression, and raise Yang Qi. The two are used together to resolve damp heat in the body and disperse qi stagnation in the liver and gallbladder.

[0049] Licorice, Alisma, Citron, Perilla Leaf, and Patchouli are all adjuvants that can harmonize the properties of the main and auxiliary drugs, harmonizing their functions and preventing the effects of the main and auxiliary drugs from canceling each other out. These adjuvants serve as auxiliary drugs, treating secondary symptoms such as abdominal distension, nausea, vomiting, and liver qi stagnation. They also serve as auxiliary pharmaceuticals to eliminate or mitigate the toxicity or potency of the main and auxiliary drugs, harmonizing their properties. They can assist the main and auxiliary drugs in nourishing the liver and stomach while harmonizing their properties, thereby balancing the yin and yang of the two drugs and avoiding side effects when taken. Among them, licorice, sweet in taste, neutral in nature, has the effects of tonifying the spleen and replenishing qi, clearing away heat and toxins, removing phlegm and relieving cough, relieving urgency and relieving pain, and harmonizing various medicines. It is used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncle and sore, and relieves the toxicity and potency of drugs. Taking it with Alisma can reduce the toxic side effects; Alisma, sweet and light in taste, cold in nature, has the effects of promoting water and dampness, purging heat, clearing turbidity and lowering lipids. It is mainly used to treat dysuria, edema, diarrhea, oliguria, phlegm and fluid dizziness, hot stranguria and pain, and hyperlipidemia; Citron is pungent, bitter and sour. It is warm and enters the liver, spleen and lung meridians, soothes the liver and regulates qi, relieves fullness and resolves phlegm. It is used for liver and stomach qi stagnation, chest and flank pain, abdominal distension, vomiting and belching, and cough with excessive phlegm; Perilla leaf is pungent and warm and enters the lung and spleen meridians. It relieves exterior symptoms and dispels cold, promotes qi and harmonizes the stomach. It is used for wind-cold colds, cough, nausea and vomiting during pregnancy; Patchouli is pungent and slightly warm and enters the spleen, stomach and lung meridians. It is aromatic and resolves turbidity, harmonizes the stomach and stops vomiting, releases the exterior and relieves heat. It is used for dampness and turbidity blocking the middle part of the body, abdominal distension and vomiting, exterior symptoms of summer-dampness, the initial onset of damp-heat, fever and fatigue, chest tightness and discomfort, summer-heat caused by cold and dampness, abdominal pain, vomiting and diarrhea, nasal sinusitis and headache, and quick hangover relief.

[0050] On the one hand, concentrated fruit and vegetable juice can improve the taste, and on the other hand, it can help sober up. Fruit and vegetable juice contains plant polyphenols, plus a variety of organic acids, vitamins and nutrients, which can greatly increase the activity of alcohol dehydrogenase and acetaldehyde dehydrogenase, accelerate the metabolism of alcohol, decompose the acetaldehyde produced by alcohol in the human body, accelerate its conversion into acetic acid, carbon dioxide and water, and eventually excrete it from the body, thereby reducing or eliminating the damage of acetaldehyde to the human body, and relieving adverse reactions such as dizziness, nausea, and vomiting after drinking; plant polyphenols in fruit and vegetable juice can relieve alcoholic liver damage, such as tea polyphenols, pomegranate leaf polyphenols, grape polyphenols, apple polyphenols, etc. have been shown to have good liver protective effects. Their mechanism of action includes activating the body's antioxidant system, inhibiting lipid peroxidation and regulating signal pathways, thereby improving liver damage.

[0051] Concentrated fruit and vegetable juice can be selected from one or two of blueberry, apple, grape, tomato, banana, watermelon, grapefruit or pear, and is made from a mixture of puree concentrate. The reason why apples can help sober up is related to the diuretic effect of containing a large amount of organic acid and potassium. This is because acidic substances can not only break down ethanol, but also stimulate the intestines to have an astringent and antidiarrheal effect; lemons are extremely sour and can react chemically with ethanol, reducing the content of ethanol in the body, thus helping to sober up; in addition to the conventional sugars, acids and vitamin C, blueberries are also rich in anthocyanins, flavonoids, polyphenols and other physiologically active ingredients, and are rich in minerals such as calcium, phosphorus and potassium, vitamins such as vitamin E, vitamin A, vitamin B1, as well as special ingredients rarely found in other fruits such as protein, fat, and cellulose, which can increase ADH activity, accelerate the alcohol metabolism process, improve the antioxidant capacity of liver tissue, eliminate oxygen free radicals, reduce lipid peroxidation, relieve fat accumulation, and regulate key enzymes in the alcohol metabolism process, downregulate the expression of CYP2E1, and upregulate HO-1 expression, reducing the body's oxidative stress response caused by long-term and heavy drinking, reducing the damage of oxidative stress to the body, improving liver function, reducing the inflammatory immune response during alcohol metabolism, and reducing the expression of inflammatory signal molecules; grapes are rich in tartaric acid, which can interact with ethanol to form esters, so as to achieve the purpose of sobering up. Fresh grapes can relieve symptoms such as nausea and vomiting after drinking; tomatoes contain vitamin C and organic acids that can neutralize ethanol, and tomato juice is rich in special fructose, which can promote the decomposition of alcohol; bananas can increase blood sugar concentration and reduce the proportion of alcohol in the blood, so as to achieve the purpose of sobering up; watermelon can clear away heat and reduce fire, so that alcohol can be quickly excreted with urine; the above fruits can dilute the alcohol concentration in the blood after being eaten by drunk people, accelerate excretion and sober up.

[0052] The hangover-relieving composition can also be supplemented with the following raw materials in proportions by weight: 0.05-1.5 parts of glutathione, 0.05-2 parts of vitamin C, 1-8 parts of sucrose, and 0.1-1.5 parts of vitamin B.

[0053] Glutathione is composed of glutamic acid, cysteine ​​and glycine, contains sulfur groups, is widely distributed in various organs of the body, and plays an important role in maintaining cellular biological functions. It can activate a variety of enzymes, thereby promoting the metabolism of sugar, fat and protein, and can affect the metabolic process of cells; it can combine with free radicals in the body through sulfur groups and can be converted into easily metabolized acids, thereby accelerating the excretion of free radicals; it can also protect the liver's synthesis, detoxification, and hormone inactivation functions, promote bile acid metabolism, and facilitate the digestive tract to absorb fat and fat-soluble vitamins; vitamin C has extremely strong reducing properties, which can prevent the composition from being oxidized when it is placed for a long time and in contact with air, and also has certain detoxification and cancer prevention effects; sucrose is sweet and odorless, easily soluble in water and glycerol, can increase the sweetness of the composition, enhance the taste of the composition, and thereby improve the patient's taking experience; vitamin B can promote alcohol metabolism.

[0054] When the hangover-relieving composition of the present invention contains the above components, glutathione and Sophora japonica flowers used together have a fat-removing effect on the liver infiltrated with fat; vitamin C and vitamin B can provide the required energy for the hangover-relieving process, supplement the vitamins required by the human body, and have a small auxiliary effect; sucrose can improve the taste; the above composition can provide material energy for hangover-relieving, accelerate the hangover-relieving process, and avoid the acute and chronic toxicity of alcohol to the human body.

[0055] The above-mentioned medicinal materials are combined in a reasonable relationship of monarch, minister, assistant and envoy. They can not only sober up and disinfect, but also protect the liver and stomach, and prevent the liver and stomach from being damaged by acetaldehyde.

[0056] The present invention also provides a method for preparing a hangover-relieving composition, which comprises at least the following steps:

[0057] Weigh the raw materials according to the raw material ratio of the above composition, crush the Sophora japonica flower, dandelion, liquorice, Alisma orientalis, Elsholtzia ciliata, Citrus aurantium, Scutellaria baicalensis, Bupleurum chinense, Citron, Perilla leaf and Patchouli officinalis respectively, add the extracting solution for extraction, filter, concentrate, and mix evenly with concentrated fruit and vegetable juice, corn peptide powder, glutathione, vitamin C, sucrose and vitamin B to obtain the product.

[0058] Among them, the above extraction is a semi-bionic extraction. Sophora japonica flower, dandelion, licorice, Alisma orientale, Elsholtzia ciliata, Citrus aurantium, Scutellaria baicalensis, Bupleurum chinense, Citron, Perilla leaf and Patchouli are crushed separately and added to the extract, heated and mixed at 80-100°C under normal pressure, decocted three times, and refluxed for extraction.

[0059] When the semi-bionic extraction method is used for the first decoction, the extraction solvent is a hydrochloric acid aqueous solution with a pH value of 2.0-2.5, the mass of the extraction solvent is 10 times the total mass of the medicinal materials, and the extraction time is 2 to 3.5 hours. When the semi-bionic extraction method is used for the first decoction, the extraction solvent is a sodium hydroxide aqueous solution with a pH value of 7.2-7.5, the mass of the extraction solvent is 8 times the total mass of the medicinal materials, and the extraction time is 80 to 100 minutes. When the semi-bionic extraction method is used for the third decoction, the extraction solvent is a sodium hydroxide aqueous solution with a pH value of 8.0-8.5, the mass of the extraction solvent is 6 times the total mass of the medicinal materials, and the extraction time is 40 to 60 minutes.

[0060] The concentration temperature is 65-80°C.

[0061] The embodiment of the present invention also provides the use of the above-mentioned hangover-relief composition in hangover-relief medicine.

[0062] The application form of the hangover-relieving composition is that the solid preparation can be granules, tablets, capsules, pills or powders; the dissolving medium in the liquid preparation can be buffer solution, physiological saline or drinking water.

[0063] The hangover-relieving composition is taken during or after drinking, once a day, with 15 g of the hangover-relieving composition taken orally for every 60 kg of body weight (calculated as crude drug) to achieve the effect of rapid hangover relief. The hangover-relieving composition has the effects of protecting the liver and nourishing the stomach, can prevent the acute and chronic toxicity of alcohol to the human body, and can also exert the effects of detoxification, lowering blood lipids, strengthening the stomach, protecting the brain, stopping vomiting, and relieving heat.

[0064] Example 1

[0065] This embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 3 parts corn peptide powder, 8 parts Sophora japonica flower, 1 part Dandelion herb, 6 parts Licorice root, 1 part Orientis rhizome, 10 parts Elsholtzia ciliata, 1 part Citrus aurantium, 5 parts Scutellaria baicalensis, 1 part Bupleurum root, 4.5 parts Citron, 1 part Perilla leaf, 4.5 parts Patchouli root, and 11 parts concentrated blueberry juice;

[0066] The preparation method of the above-mentioned hangover-relieving composition comprises the following steps: weighing each raw material according to the raw material ratio of the above-mentioned composition, screening Sophora japonica flower, dandelion, liquorice, oriental rhizome, Elsholtzia ciliata, dried orange peel, scutellaria baicalensis, bupleurum root, citron, perilla leaf and patchouli, washing and drying, heating in a microwave heating device with a frequency of 3000 MHz for 3 minutes to sterilize, crushing them separately, passing them through a 10-20 mesh sieve, mixing them evenly, boiling and extracting them with water, filtering, centrifuging at a speed of 3000 r / min and a centrifugation time of 15 minutes, combining the supernatants, concentrating them, and mixing them evenly with concentrated blueberry juice to obtain the composition.

[0067] Example 2

[0068] This embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 18 parts corn peptide powder, 1 part Sophora japonica flower, 9 parts Taraxacum mongolicum, 1 part Licorice root, 5 parts Orientis rhizome, 2 parts Elsholtzia ciliata, 6 parts Citrus aurantium, 1 part Scutellaria baicalensis, 6 parts Bupleurum root, 0.5 part Citron, 3.5 parts Perilla leaf, 1 part Patchouli sinensis, and 23 parts concentrated apple juice;

[0069] The preparation method of the above-mentioned hangover-relieving composition comprises the following steps: weighing each raw material according to the raw material ratio of the above-mentioned composition, screening, washing and drying Sophora japonica flower, dandelion, liquorice, oriental rhizome, elsholtzia ciliata, dried orange peel, scutellaria baicalensis, bupleurum root, citron, perilla leaf and patchouli, heating for 3 minutes in a microwave heating device with a frequency of 3000 MHz for sterilization, crushing them respectively, passing them through a 10-20 mesh sieve, weighing the coarse powder of the medicinal materials respectively according to the proportion, mixing them uniformly, adopting a semi-bionic extraction method, heating and refluxing at 80°C under normal pressure for 3 times, adding water in an amount of 10, 8 and 6 times the amount of the medicinal materials respectively, mixing and decocting, and the first decoction is a pH value of 1. The extract is prepared by using a hydrochloric acid aqueous solution with a pH value of 2.0-2.5 and an extraction time of 2 hours. The second decoction is a sodium hydroxide aqueous solution with a pH value of 7.2-7.5 and an extraction time of 90 minutes. The third decoction is a sodium hydroxide aqueous solution with a pH value of 8.0-8.5 and an extraction time of 50 minutes. The double extraction method is used. The extract is filtered through four layers of gauze and a 100-mesh sieve respectively, and centrifuged at a speed of 3000 r / min and a centrifugal time of 20 minutes. The supernatants are combined and concentrated in a water bath (evaporation and concentration are performed in a water bath at 80°C), cooled to about 50°C, and the concentrate is evenly mixed with concentrated apple juice to obtain the product.

[0070] Example 3

[0071] This embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 10 parts corn peptide powder, 5 parts Sophora japonica flower, 5 parts Taraxacum mongolicum, 4 parts Licorice root, 4 parts Orientis rhizome, 6 parts Elsholtzia ciliata, 4 parts Citrus aurantium, 3 parts Scutellaria baicalensis, 4 parts Bupleurum root, 3 parts Citron, 2 parts Perilla leaf, 3 parts Patchouli sinensis, and 20 parts concentrated grape juice;

[0072] The preparation method of the above-mentioned hangover-relieving composition comprises the following steps: weighing each raw material according to the raw material ratio of the above-mentioned composition, screening, washing and drying Sophora japonica flower, dandelion, liquorice, oriental rhizome, elsholtzia ciliata, dried orange peel, scutellaria baicalensis, bupleurum root, citron, perilla leaf and patchouli, heating for 3 minutes in a microwave heating device with a frequency of 3000 MHz for sterilization, crushing them separately, passing them through a 10-20 mesh sieve, mixing them evenly, boiling and extracting them with water, filtering, centrifuging at a speed of 3000 r / min and a centrifugation time of 17 minutes, combining the supernatants, concentrating them, and mixing them evenly with concentrated grape juice to obtain the composition.

[0073] Example 4

[0074] This embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 3 parts corn peptide powder, 4 parts Sophora japonica flower, 1 part Dandelion herb, 2 parts Licorice root, 1 part Orientis rhizome, 3 parts Elsholtzia ciliata, 1 part Citrus aurantium, 2 parts Scutellaria baicalensis, 1 part Bupleurum root, 2 parts Citron, 1 part Perilla leaf, 2 parts Patchouli sinensis, and 13 parts concentrated tomato juice;

[0075] The preparation method of the above-mentioned hangover-relieving composition comprises the following steps: screening, washing and drying, placing Sophora japonica flower, dandelion, liquorice, oriental rhizome, elsholtzia ciliata, dried orange peel, scutellaria baicalensis, bupleurum root, citron, perilla leaf and patchouli in a microwave heating device with a frequency of 3000 MHz for heating for 3 minutes to sterilize, crushing them respectively, passing them through a 10-20 mesh sieve, weighing the coarse powder of the medicinal materials according to proportion, mixing them evenly, using a semi-bionic extraction method, heating and refluxing at 100°C under normal pressure for 3 times, adding water in an amount of 10, 8 and 6 times the amount of the medicinal materials respectively, mixing and decocting, wherein the first decoction is hydrochloric acid with a pH value of 2.0-2.5 The extract was prepared by the double extraction method. The extract was filtered through four layers of gauze and a 100-mesh sieve, and the centrifugation speed was 3000 r / min and the centrifugation time was 20 min. The supernatants were combined and concentrated in a water bath (evaporation and concentration were performed in a 65°C water bath), cooled to about 50°C, and the concentrate was evenly mixed with concentrated tomato juice.

[0076] Example 5

[0077] This embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 16 parts corn peptide powder, 1 part Sophora japonica flower, 2 parts Taraxacum mongolicum, 1 part Licorice root, 2 parts Orientis rhizome, 2 parts Elsholtzia ciliata, 2 parts Citrus aurantium, 1 part Scutellaria baicalensis, 2 parts Bupleurum chinense, 1 part Citron, 2 parts Perilla leaf, 1 part Patchouli rugosa, and 20 parts concentrated banana juice;

[0078] The preparation method of the above-mentioned hangover-relieving composition is the same as the preparation method in Example 1.

[0079] Example 6

[0080] This embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 10 parts corn peptide powder, 1 part Sophora japonica flower, 1.5 parts Dandelion herb, 1.2 parts Licorice root, 1 part Orientis rhizome, 2.5 parts Elsholtzia ciliata, 1.2 parts Citrus aurantium, 1.5 parts Scutellaria baicalensis, 2 parts Bupleurum root, 1.5 parts Citron, 1 part Perilla leaf, 1 part Patchouli root, and 15 parts concentrated watermelon juice;

[0081] The preparation method of the above-mentioned hangover-relieving composition is the same as the preparation method in Example 2.

[0082] Example 7

[0083] This embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 3 parts corn peptide powder, 8 parts Sophora japonica flower, 1 part Dandelion herb, 6 parts Licorice root, 1 part Orientale rhizome, 10 parts Elsholtzia ciliata, 1 part Citrus aurantium, 5 parts Scutellaria baicalensis, 1 part Bupleurum root, 4.5 parts Citron, 1 part Perilla leaf, 4.5 parts Patchouli root, 11 parts concentrated grapefruit juice, 1.5 parts glutathione, 0.05 parts vitamin C, 8 parts sucrose, and 0.1 parts vitamin B.

[0084] The preparation method of the above-mentioned hangover-relieving composition comprises the following steps: weighing each raw material according to the raw material ratio of the above-mentioned composition, screening, washing and drying Sophora japonica flower, dandelion, liquorice, oriental rhizome, elsholtzia ciliata, dried orange peel, scutellaria baicalensis, bupleurum root, citron, perilla leaf and patchouli, heating for 3 minutes in a microwave heating device with a frequency of 3000 MHz for sterilization, crushing them separately, passing them through a 10-20 mesh sieve, mixing them evenly, boiling and extracting them with water, filtering, centrifuging at a speed of 3000 r / min and a centrifugation time of 15 minutes, combining the supernatants, concentrating them, and evenly mixing them with concentrated grapefruit juice, glutathione, vitamin C, sucrose and vitamin B to obtain the composition.

[0085] Example 8

[0086] The present embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 18 parts corn peptide powder, 1 part Sophora japonica flower, 9 parts Taraxacum mongolicum, 1 part Licorice root, 5 parts Orientis rhizome, 2 parts Elsholtzia ciliata, 6 parts Citrus aurantium, 1 part Scutellaria baicalensis, 6 parts Bupleurum root, 0.5 part Citron, 3.5 parts Perilla leaf, 1 part Patchouli root, 23 parts concentrated pear juice, 0.05 part glutathione, 2 parts Vitamin C, 1 part sucrose, and 1.5 parts Vitamin B12;

[0087] The preparation method of the above-mentioned hangover-relieving composition comprises the following steps: weighing each raw material according to the raw material ratio of the above-mentioned composition, screening, washing and drying, placing in a microwave heating device with a frequency of 3000 MHz for heating for 3 minutes to sterilize, crushing respectively, passing through a 10-20 mesh sieve, weighing the coarse powder of the medicinal materials respectively according to the proportion, mixing evenly, adopting a semi-bionic extraction method, heating and refluxing at 90°C under normal pressure for 3 times, adding water in an amount of 10, 8 and 6 times the amount of the medicinal materials respectively, mixing and decocting, wherein the first decoction is hydrochloric acid with a pH value of 2.0-2.5 Aqueous solution, extraction time 2 to 3.5h, the second decoction is a sodium hydroxide aqueous solution with a pH value of 7.2-7.5, the extraction time is 90min, the third decoction is a sodium hydroxide aqueous solution with a pH value of 8.0-8.5, the extraction time is 50min, double extraction method extraction, the extract is filtered with four layers of gauze and 100 mesh sieve respectively, centrifuged at a speed of 3000r / min, the centrifugation time is 20min, the supernatant is combined, concentrated in a water bath (evaporation concentration is carried out in a 70℃ water bath), cooled to about 50℃, and the concentrate is evenly mixed with concentrated pear juice, glutathione, vitamin C, sucrose and vitamin B.

[0088] Example 9

[0089] This embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 10 parts corn peptide powder, 5 parts Sophora japonica flower, 5 parts Taraxacum mongolicum, 4 parts Licorice root, 4 parts Orientis rhizome, 6 parts Elsholtzia ciliata, 4 parts Citrus aurantium, 3 parts Scutellaria baicalensis, 4 parts Bupleurum root, 3 parts Citron, 2 parts Perilla leaf, 3 parts Patchouli, 20 parts concentrated blueberry and tomato juice (the weight ratio of blueberry to tomato is 1:1), 1 part glutathione, 1 part vitamin C, 4 parts sucrose, and 1 part vitamin B12;

[0090] The preparation method of the above-mentioned hangover-relieving composition is the same as that of Example 7.

[0091] Example 10

[0092] This embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 3 parts corn peptide powder, 4 parts Sophora japonica flower, 1 part Dandelion herb, 2 parts Licorice root, 1 part Orientale rhizome, 3 parts Elsholtzia ciliata, 1 part Citrus aurantium, 2 parts Scutellaria baicalensis, 1 part Bupleurum root, 2 parts Citron, 1 part Perilla leaf, 2 parts Patchouli, 13 parts concentrated apple and grape juice (the mass ratio of apple to grape is 1:1), 0.2 parts glutathione, 0.05 parts vitamin C, 3 parts sucrose, and 0.1 parts vitamin B.

[0093] The preparation method of the above-mentioned hangover-relieving composition is the same as that of Example 8.

[0094] Example 11

[0095] This embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 16 parts corn peptide powder, 1 part Sophora japonica flower, 2 parts Taraxacum mongolicum, 1 part Licorice root, 2 parts Orientalis rhizome, 2 parts Elsholtzia ciliata, 2 parts Citrus aurantium, 1 part Scutellaria baicalensis, 2 parts Bupleurum chinense, 1 part Citron, 2 parts Perilla frutescens, 1 part Patchouli, 20 parts concentrated banana and watermelon juice (the mass ratio of banana to watermelon is 1:1), 0.05 parts glutathione, 0.2 parts vitamin C, 1 part sucrose, and 0.3 parts vitamin B.

[0096] The preparation method of the above-mentioned hangover-relieving composition is the same as that of Example 7.

[0097] Example 12

[0098] This embodiment provides a hangover-relieving composition, comprising the following raw materials in parts by weight: 10 parts corn peptide powder, 1 part Sophora japonica flower, 1.5 parts Dandelion herb, 1.2 parts Licorice root, 1 part Orientale rhizome, 2.5 parts Elsholtzia ciliata, 1.2 parts Citrus aurantium, 1.5 parts Scutellaria baicalensis, 2 parts Bupleurum root, 1.5 parts Citron, 1 part Perilla leaf, 1 part Patchouli root, 15 parts concentrated blueberry and grapefruit juice (blueberry to grapefruit ratio of 1:1 by weight), 0.2 parts glutathione, 0.1 parts vitamin C, 2 parts sucrose, and 0.2 parts vitamin B.

[0099] The preparation method of the above-mentioned hangover-relieving composition is the same as that of Example 8.

[0100] Effect Examples

[0101] The hangover-relieving compositions of Examples 1-12 were respectively prepared into experimental products with product ingredients accounting for 75% and normal saline accounting for 25% for the following test measurements.

[0102] 1. Test steps:

[0103] (1) Screening experiment on the optimal alcohol dosage for mice:

[0104] Due to differences between individual mice and problems with the mice's own functions, mice may be overly sensitive or tolerant to alcohol. Therefore, it is necessary to screen mice with moderate sensitivity to alcohol to minimize individual differences.

[0105] 126 mice were randomly divided into seven groups and gavaged with 0.10 mL / 10 g, 0.11 mL / 10 g, 0.12 mL / 10 g, 0.13 mL / 10 g, 0.14 mL / 10 g, 0.15 mL / 10 g, and 0.16 mL / 10 g of 55% Red Star Erguotou. Following gavage, the mice were observed for 2.5 hours to assess their intoxication. Intoxication was assessed by the loss of the righting reflex when the mouse turned over on its stomach for at least 25 seconds. The amount of alcohol administered and the intoxication rate of each group are shown in Table 1.

[0106] Table 1

[0107]

[0108] The above experimental data show that when mice are given alcohol at a dose of 0.14mL / 10g, the drunkenness rate is high and the mortality rate is low, so this dose is used as the alcohol dose for screening mice.

[0109] (2) 325 mice were gavaged with 0.14 ml / 10 g of Red Star Erguotou. The mice were observed for intoxication. Mice that were intoxicated for ≤10 min or within 2.5 h were excluded. The remaining mice were used to study the effects of the product on sobering up, protecting the liver and brain.

[0110] (3) Study on the effect of sobering up, protecting liver and brain products: The remaining mice were randomly divided into 13 groups: 0 control group (normal saline group) and 12 experimental groups, with 18 mice in each group. Before the experiment (24 hours after the experiment in step (2)), the liver function and alcohol content in the body of each group of mice were tested to avoid the influence of the alcohol injection experiment in step (2) on the body function of the mice. To a certain extent, the variables were controlled, and the ethanol content in the blood of the mice was used to determine whether the mice were sober. The liver function index and blood ethanol content index of each group of mice are shown in Table 2:

[0111] Table 2

[0112]

[0113] There were no significant differences in the above indicators among the mice in each group, and subsequent experiments can be carried out.

[0114] The control group was gavaged with normal saline, and the 12 experimental groups were gavaged with suspensions made from the hangover-relieving compositions of Examples 1-12 (the hangover-relieving compositions of each example were mixed with water in a ratio of 3:1), with a dosage of 0.1 ml / 10 g. 25 minutes later, the mice were gavaged with 55-degree Red Star Erguotou, and the drunkenness time and soberness time of each group of mice were observed and recorded. The drugs were administered for 30 consecutive days (first the drug and then the alcohol was administered every day), and the drunkenness time and soberness time of each group of mice were recorded every day: the time from the start of alcohol administration to the disappearance of the righting reflex was the drunkenness time, and the time from the disappearance of the righting reflex to the recovery of the righting reflex was the soberness time. After the last administration of alcohol, the mice were killed, their eyeballs were removed to collect blood, and the serum was separated. The levels of AST and ALT in the serum were detected using a fully automatic biochemical analyzer;

[0115] The average drunkenness time and soberness time of each group of mice within 30 days are shown in Table 3:

[0116] Table 3

[0117]

[0118] The results of the drunkenness time and soberness time of the above-mentioned groups of mice showed that the hangover detoxification composition of the embodiment of the present invention significantly prolonged the drunkenness time of mice and shortened the soberness time of mice (P<0.01), which was statistically significant compared with the saline group.

[0119] The results of this study found that except for the product group, all other groups achieved a significant reduction in the time taken to sober up, indicating that each product group has a significant effect in sobering up and preventing drunkenness.

[0120] After drinking, 95% of the ethanol absorbed into the body is metabolized in the liver. Most of it is oxidized by alcohol dehydrogenase in the liver, producing a large amount of acetaldehyde and nicotinamide adenine dinucleotide. A small part is oxidized by the liver microsomal ethanol metabolic enzyme system, producing a large amount of free radicals. Long-term drinking produces a large amount of toxic substances, which damage the liver and lead to alcoholic fatty liver or alcoholic hepatitis. Among the indicators of liver function, ALB and ALT are sensitive markers of liver damage. Free radicals are produced during the metabolism of ethanol and acetaldehyde, which attack the liver cell membrane and affect the permeability of the liver cell membrane. ALT and AST in the cytoplasm overflow into the liver sinusoids and enter the peripheral blood, and the serum ALT and AST activities increase; liver damage is manifested as elevated serum ALT, accumulation of triglycerides in the liver and cell swelling. The effects of the alcohol detoxification composition of the embodiment of the present invention on the liver function of mice are shown in Table 4:

[0121] Table 4

[0122]

[0123] The results of the liver function tests of the mice in the above groups showed that the serum AST and ALT levels of the mice in the experimental group were significantly lower than those in group 0 (normal saline group) (P<0.05), indicating that the alcohol detoxification composition of the present invention has a significant protective effect on the liver function of long-term alcohol consumption.

[0124] In summary, the hangover-detoxifying composition of the embodiment of the present invention can significantly shorten the time of drunkenness and sobering up in mice, accelerate the metabolism of alcohol in the body, has good anti-drunkenness and fast-acting hangover-detoxification functions, and has obvious hangover-detoxification and liver-protection effects.

[0125] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions or improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A hangover-relieving pharmaceutical composition, characterized in that: The invention is composed of the following raw materials in the following weight proportions: 3-18 parts of corn peptide powder, 1-8 parts of Sophora japonica flowers, 1-9 parts of dandelions, 1-6 parts of liquorice, 1-5 parts of oriental rhizome, 2-10 parts of elsholtzia ciliata, 1-6 parts of dried orange peel, 1-5 parts of scutellaria baicalensis, 1-6 parts of bupleurum root, 0.5-4.5 parts of citron, 1-3.5 parts of perilla leaves, 1-4.5 parts of patches of patchouli and 11-23 parts of concentrated fruit and vegetable juice.

2. The hangover-relieving pharmaceutical composition according to claim 1, wherein: The invention is composed of the following raw materials in the following weight proportions: 3-16 parts of corn peptide powder, 1-4 parts of Sophora japonica flower, 1-2 parts of dandelion, 1-2 parts of liquorice, 1-2 parts of Alisma orientale, 2-3 parts of Elsholtzia ciliata, 1-2 parts of Citrus aurantium, 1-2 parts of Scutellaria baicalensis, 1-2 parts of Bupleurum chinense, 1-2 parts of Citron, 1-2 parts of Perilla leaf, 1-2 parts of Patchouli and 13-20 parts of concentrated fruit and vegetable juice.

3. The hangover-relieving pharmaceutical composition according to claim 2, wherein: The invention is composed of the following raw materials in the following weight proportions: 10 parts of corn peptide powder, 1 part of Sophora japonica flower, 1.5 parts of dandelion, 1.2 parts of licorice, 1 part of Alisma orientale, 2.5 parts of Elsholtzia ciliata, 1.2 parts of Citrus aurantium, 1.5 parts of Scutellaria baicalensis, 2 parts of Bupleurum chinense, 1.5 parts of Citron, 1 part of Perilla leaf, 1 part of Patchouli grandiflora and 15 parts of concentrated fruit and vegetable juice.

4. The hangover-relieving pharmaceutical composition according to any one of claims 1 to 3, wherein 0.05-1.5 parts of glutathione, 0.05-2 parts of vitamin C and 0.1-1.5 parts of vitamin B are also added.

5. The hangover-relieving pharmaceutical composition according to claim 4, wherein 0.05-0.2 parts of glutathione, 0.05-0.2 parts of vitamin C and 0.1-0.3 parts of vitamin B are also added.

6. The hangover-relieving pharmaceutical composition according to claim 5, wherein 0.2 parts of glutathione, 0.1 parts of vitamin C and 0.2 parts of vitamin B were also added.

7. A method for preparing a hangover-relieving pharmaceutical composition, characterized in that: The method comprises the following steps: weighing the raw materials according to the raw material ratio of the composition according to any one of claims 1 to 6, crushing the sophora japonica flower, dandelion, liquorice, oriental rhizome, elsholtzia ciliata, red orange peel, scutellaria baicalensis, bupleurum root, citron, perilla leaf and patchouli respectively, extracting with an extraction solvent, filtering, concentrating and uniformly mixing with the remaining raw materials to obtain the product.

8. The method for preparing the hangover-relieving pharmaceutical composition according to claim 7, wherein: The extraction is a semi-bionic extraction, wherein the flowers of Sophora japonica, dandelion, liquorice, rhizome of Alisma orientalis, elsholtzia ciliata, dried orange peel, scutellaria baicalensis, bupleurum, citron, perilla leaf and patchouli are crushed respectively, and then an extraction solvent is added, the mixture is heated at 80-100° C. under normal pressure, mixed and decocted three times, and refluxed for extraction.

9. The method for preparing the alcohol-relieving pharmaceutical composition according to claim 7, wherein: The concentration temperature is 65-80°C.

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