A multifunctional integrated photomedical device

Abstract

This application discloses a multifunctional integrated photomedical device, comprising: a photofunctional layer; two main electrode layers with opposite polarities, located on opposite sides of the photofunctional layer; a drug layer located on the light-emitting side of the photomedical device; and an electrode for attaching to phototherapy tissue. The photomedical device powers the two main electrode layers to activate the photofunctional layer; and generates an electric field for drug delivery by powering either main electrode layer or the electrode. This application achieves highly efficient drug delivery in a highly integrated manner without altering the OLED device structure, thereby improving the therapeutic effect of the photomedical device.

Description

Technical Field

[0001] This disclosure generally relates to the field of photomedicine technology, and specifically to a multifunctional integrated photomedicine device. Background Technology

[0002] OLEDs are optoelectronic devices that emit light through carrier injection and recombination. Specifically, electrons are injected through a metal cathode and transported to the emissive layer via an electron transport material, while holes are injected through a metal anode and transported to the emissive layer via a hole transport material. Electrons and holes recombine in the emissive layer to form excitons, which then degenerate to emit light. OLEDs have attracted considerable attention due to their excellent light emission uniformity, thinness, bendability, flexibility, and stretchability. These characteristics also make OLEDs suitable for fabricating wearable photomedical devices.

[0003] Typically, a drug layer is coated on the light-emitting surface of an OLED or on the affected area, allowing the drug to diffuse into the body. However, this method has relatively low phototherapy efficiency. This invention aims to develop a highly efficient, multifunctional, integrated phototherapy device. Summary of the Invention

[0004] In view of the above-mentioned defects or deficiencies in the prior art, it is desirable to provide a multifunctional integrated photomedical device.

[0005] In a first aspect, this application provides a multifunctional integrated photomedical device, the photomedical device comprising:

[0006] Optical functional layer;

[0007] Two main electrode layers with opposite polarities are located on both sides of the optical functional layer;

[0008] The drug layer is located on the light-emitting side of the photomedical device;

[0009] The electrode is introduced and attached to the phototherapy tissue;

[0010] The photomedical device enables the photofunctional layer to function by supplying power to two main electrode layers; the photomedical device generates an electric field for drug delivery by supplying power to either main electrode layer and the delivery electrode.

[0011] According to the technical solution provided in the embodiments of this application, the magnitude and / or direction of the power supply current supplied by the photomedical device to the photofunctional layer and the electric field are different.

[0012] According to the technical solution provided in the embodiments of this application, the main electrode layer includes a first main electrode layer and a second main electrode layer; the power supply circuit of the photomedical device includes a first power supply terminal and a second power supply terminal with opposite polarities, the first power supply terminal is used to connect to the first main electrode layer, and the second power supply terminal is alternately connected to the second main electrode layer and the induction electrode through a control circuit.

[0013] According to the technical solution provided in the embodiments of this application, the power supply circuit is a pulse power supply with alternating positive and negative signals.

[0014] According to the technical solution provided in the embodiments of this application, the drug layer is a gel doped with a drug.

[0015] According to the technical solution provided in the embodiments of this application, any main electrode layer and drug layer are located on opposite sides of the substrate layer; an isolation layer is provided on the side of the substrate layer that is relatively close to the drug layer; the material of the isolation layer is at least one of indium tin oxide coating or aerogel; and the isolation layer is preferably doped with scattering particles.

[0016] According to the technical solution provided in the embodiments of this application, any main electrode layer and drug layer are located on both sides of the substrate layer; a first water-blocking layer is provided on the side of the substrate layer that is relatively close to the main electrode layer; the first water-blocking layer is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin; the water-blocking layer is prepared by at least one of ALD, PECVD, IJP, screen printing or sputtering.

[0017] According to the technical solution provided in the embodiments of this application, the photomedical device includes an encapsulation layer, and a second water-blocking layer is provided on the side of the encapsulation layer near the photofunctional layer. The second water-blocking layer is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin. The water-blocking layer is prepared by at least one of ALD, PECVD, IJP, screen printing or sputtering.

[0018] According to the technical solution provided in the embodiments of this application, the photomedical device includes an encapsulation layer, and a barrier adhesive layer is provided on the side of the encapsulation layer near the photofunctional layer. The barrier adhesive layer is composed of at least one of polyolefin and rubber; the barrier adhesive layer is doped with a water-absorbing material.

[0019] According to the technical solution provided in the embodiments of this application, the drug layer partially covers the light-emitting side of the photomedical device.

[0020] In the technical solution of this application, by setting an induction electrode in the photomedical device, the photomedical device forms an electric field for drug delivery by supplying power to any main electrode layer and the induction electrode; without changing the device structure of the OLED itself, efficient drug delivery is achieved in a highly integrated manner, thereby improving the therapeutic effect of the photomedical device. Attached Figure Description

[0021] Other features, objects and advantages of the present application will become more apparent upon reading the detailed description of non-limiting embodiments made with reference to the following drawings:

[0022] Figure 1 This is a schematic diagram of the first device structure in Example 1;

[0023] Figure 2 This is a schematic diagram of the second device structure in Example 1;

[0024] Figure 3 This is a schematic diagram of the third device structure in Example 1;

[0025] Figure 4 This is a schematic diagram of the fourth device structure in Example 1;

[0026] Figure 5 This is a schematic diagram of the fifth device structure in Example 1;

[0027] Figure 6 This is a schematic diagram of the sixth device structure in Example 1;

[0028] Figure 7 This is a schematic diagram of the seventh device structure in Example 1;

[0029] Figure 8 This is a schematic diagram of the eighth device structure in Example 1;

[0030] Figure 9 This is a schematic diagram of the eighth device structure in Example 1;

[0031] Figure 10 and Figure 11 This is a schematic diagram of the drug layer structure in Example 1;

[0032] Figure 12 This is a schematic diagram of the pulse power supply circuit in Example 1;

[0033] Figure 13 This is a schematic diagram of the pulse power supply circuit in Example 1;

[0034] Numbers in the figure:

[0035] 10. Substrate layer; 20. Positive electrode layer; 30. Negative electrode layer; 40. Photofunctional layer; 30. Negative electrode layer; 50. Encapsulation layer; 60. Drug layer; 70. Delivery electrode; 80. Phototherapy tissue; 93. First power supply terminal; 94. Second power supply terminal; 95. Control circuit; 100. Isolation layer; 110. First water-blocking layer; 120. Second water-blocking layer; 130. Barrier adhesive layer. Detailed Implementation

[0036] The present application will now be described in further detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and not intended to limit it. Furthermore, it should be noted that, for ease of description, only the parts relevant to the invention are shown in the accompanying drawings.

[0037] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other. This application will now be described in detail with reference to the accompanying drawings and embodiments.

[0038] This embodiment provides a multifunctional integrated photomedical device, including:

[0039] Optical functional layer 40;

[0040] Two main electrode layers with opposite polarities are located on both sides of the optical functional layer;

[0041] Drug layer 60 is located on the light-emitting side of the photomedical device;

[0042] The electrode 70 is used to attach to the phototherapy tissue.

[0043] The photomedical device enables the photofunctional layer to function by supplying power to two main electrode layers; the photomedical device generates an electric field for drug delivery by supplying power to either main electrode layer and the delivery electrode.

[0044] The main electrode layer includes a first main electrode layer and a second main electrode layer; the power supply circuit of the photomedical device includes a first power supply terminal 91 and a second power supply terminal 92 with opposite polarities. The first power supply terminal 91 is used to connect to the first main electrode layer, and the second power supply terminal 92 is alternately connected to the second main electrode layer and the inlet electrode through a control circuit.

[0045] When the first main electrode layer is a positive electrode layer 20, the second main electrode layer is a negative electrode layer 30; when the first main electrode layer is a negative electrode layer 30, the second main electrode layer is a positive electrode layer 20.

[0046] When the first power supply terminal 91 is connected to the positive electrode layer 20, the second power supply terminal 92 is alternately connected to the negative electrode layer 30 and the induction electrode 70 through the control circuit. At this time, when the power supply circuit supplies power to the positive electrode layer 20 and the induction electrode 70, an electric field for drug delivery is formed between the positive electrode layer 20 and the human body.

[0047] When the first power supply terminal 91 is connected to the negative electrode layer 30, the second power supply terminal 92 is alternately connected to the positive electrode layer 20 and the induction electrode 70 through a control circuit. At this time, when the power supply circuit supplies power to the negative electrode layer 30 and the induction electrode, an electric field for drug delivery is formed between the negative electrode layer 30 and the human body.

[0048] When the control circuit is an integrated circuit within the control chip of the photomedical device, the switching of the second power supply terminal 92 can be achieved by setting the control program of the integrated circuit. In this case, the control circuit is the integrated circuit within the control chip. The control chip can be, for example, a microcontroller or an ARM controller.

[0049] In the embodiments of this application, the photomedical device is an OLED device, with the first main electrode layer, the light function layer and the second main electrode layer sequentially attached to the substrate layer 10 and encapsulated by the encapsulation layer 50.

[0050] like Figures 1-4 As shown, the photomedical device in this embodiment can be a bottom-emitting device or a top-emitting device, and the specific structure of each device layer can be as follows:

[0051] 1. For example Figure 1 As shown, from bottom to top in the figure, the components include: drug layer 60, substrate layer 10, positive electrode layer 20, optical functional layer 40, negative electrode layer 30, and encapsulation layer 50. The device emits light from the substrate layer 10 side (in the direction of the arrow in the figure), and the drug layer 60 is used for contact with the skin.

[0052] 2. For example Figure 2 As shown, from bottom to top in the figure, it includes: drug layer 60, substrate layer 10, negative electrode layer 30, optical functional layer 40, positive electrode layer 20, and encapsulation layer 50; the device emits light from the substrate layer 10 side (in the direction of the arrow in the figure), and the drug layer 60 is used for contact with the skin;

[0053] 3. For example Figure 3 As shown, from bottom to top in the figure, the components are: substrate layer 10, positive electrode layer 20, optical functional layer 40, negative electrode layer 30, encapsulation layer 50, and drug layer 60; the device emits light from the encapsulation layer 50 side (in the direction of the arrow in the figure), and the drug layer 60 is used for contact with the skin.

[0054] 4. For example Figure 4As shown, from bottom to top in the figure, the components are: substrate layer 10, negative electrode layer 30, optical functional layer 40, positive electrode layer 20, encapsulation layer 50, and drug layer 60. The device emits light from the encapsulation layer 50 side (in the direction of the arrow in the figure), and the drug layer 60 is used for contact with the skin.

[0055] The drug layer is an ionizable drug that can ionize under an electric field and move with the field. For example, the drug layer may be a gel doped with the drug, and the gel may contain doped ions. Typically, the drug dissociates directly under an electric field, and then the drug ions move along the electric field. For example, introducing potassium chloride (potassium ions are cations) can increase neuromuscular excitability and is used to treat peripheral neuritis and nerve paralysis. Another example is introducing the traditional Chinese medicine Aconitum carmichaelii (its main component is alkaloids, containing cations), which can treat joint pain and nerve pain caused by bone hyperplasia. The most common method for treating bone hyperplasia is to use edible vinegar (the main component of edible vinegar is acetic acid, containing anions) as the introduced drug. Under the influence of an electric field, acetate ions enter the body through the skin, interact with calcium ions on the bones, reduce calcium salt deposition, and reduce inflammation and pain. Simultaneously, phototherapy can also reduce inflammation and pain, achieving the goal of treating bone hyperplasia through a synergistic effect.

[0056] The power supply circuit provides power to the electric field based on the characteristics of the ions in the drug layer. If the ions in the drug layer are cations, the second electrode, which is used to adhere to the skin, is the anode and connected to the positive terminal of the power supply, while the opposite first electrode is the cathode and connected to the negative terminal. If the ions in the drug layer are anions, the second electrode, which is used to adhere to the skin, is the cathode and connected to the negative terminal of the power supply, while the opposite first electrode is the anode and connected to the positive terminal.

[0057] In this embodiment, the power supply design of the photomedical device adopts the following approach:

[0058] like Figure 1 and Figure 3 As shown, the first power supply terminal 91 of the power supply circuit is electrically connected to the positive electrode layer 20. When the second power supply terminal 92 is switched to be electrically connected to the negative electrode layer 30 through the control circuit 95, the OLED device emits light. When the second power supply terminal 92 is switched to be electrically connected to the delivery electrode through the control circuit 95, an electric field is formed between the positive electrode layer 20 and the phototherapy tissue (such as human skin), which promotes the delivery of drugs in the drug layer into the skin.

[0059] exist Figure 1 and Figure 3 In the structure shown, when the ions in the drug layer 60 are anions, the power supply circuit supplies power to the optical functional layer and the electric field in the same direction, that is, the first power supply terminal 91 is the anode and the second power supply terminal 92 is the cathode.

[0060] exist Figure 1 and Figure 3 In the structure shown, when the ions in the drug layer 60 are cations, the power supply circuit supplies power to the optical functional layer and the electric field in opposite directions. That is, when supplying power to the optical functional layer, the first power supply terminal 91 is the anode and the second power supply terminal 92 is the cathode; when supplying power to the electric field, the second power supply terminal 92 is the anode and the first power supply terminal 91 is the cathode.

[0061] At this time, as Figure 12 As shown, the power supply circuit is powered by alternating positive and negative pulses. The optical functional layer operates during positive pulses, and the electric field operates during negative pulses. The amplitude of the positive pulses is greater than that of the negative pulses.

[0062] exist Figure 2 and Figure 4 In the structure shown, when the ions in the drug layer 60 are cations, the power supply circuit supplies power to the light functional layer and the electric field in the same direction, that is, the second power supply terminal 92 is the anode and the first power supply terminal 91 is the cathode.

[0063] exist Figure 2 and Figure 4 In the structure shown, when the ions in the drug layer 60 are anions, the power supply circuit supplies power to the optical functional layer and the electric field in opposite directions. That is, when supplying power to the optical functional layer, the second power supply terminal 92 is the anode and the first power supply terminal 91 is the cathode; when supplying power to the electric field, the first power supply terminal 91 is the anode and the second power supply terminal 92 is the cathode.

[0064] At this time, as Figure 13 As shown, the power supply circuit is powered by alternating positive and negative pulses. The optical functional layer operates during negative pulses, and the electric field operates during positive pulses. The amplitude of the positive pulse is smaller than that of the negative pulse.

[0065] In some embodiments of this application, the magnitude and / or direction of the power supply current supplied by the photomedical device to the photofunctional layer and the electric field are different.

[0066] Because the power supply magnitude and / or direction requirements of the two functional circuits are different—for example, when the optical functional layer is working, the power supply current is 100mA, while when the drug delivery electric field is working, the power supply current is 10mA—the magnitude and / or direction of the power supply current when the two power supply circuits are working can be adjusted through the control chip of the photomedical device.

[0067] Optionally, the switching frequency of the control chip control circuit is 0.1-240Hz per second, preferably 10-100Hz per second.

[0068] In some embodiments of this application, such as Figure 6As shown, when the light emission direction of the photomedical device is located on one side of the encapsulation layer, the encapsulation layer 50 has an isolation layer 100 on the side closer to the drug layer; for example... Figure 5 As shown, when the light emission direction of the photomedical device is located on one side of the substrate layer 10, the substrate layer 10 has an isolation layer 100 on the side relatively close to the drug layer 60; the isolation layer 100 is made of at least one of indium tin oxide coating or aerogel; the isolation layer 100 is preferably doped with scattering particles. The isolation layer 100 is used to isolate and improve the light emission of the OLED, and its material is indium tin oxide coating, aerogel, etc., and it contains scattering particles, such as titanium oxide. That is, the isolation layer 100 can act as an insulating layer.

[0069] In some embodiments of this application, such as Figure 7 As shown, the substrate layer 10 has a first water-blocking layer 110 on the side closest to the optical functional layer 40. The first water-blocking layer 110 is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin, or polyolefin. The water-blocking layer is prepared by at least one of ALD, PECVD, IJP, screen printing, or sputtering. The first water-blocking layer 110 is used to block water and oxygen, which can improve the encapsulation and water and oxygen resistance of the photomedical device and increase its lifespan.

[0070] In some embodiments of this application, such as Figure 8 As shown, a second water-blocking layer 120 is provided between the encapsulation layer 50 and the optical functional layer 40. The second water-blocking layer 120 is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin, or polyolefin. The water-blocking layer is prepared by at least one of ALD, PECVD, IJP, screen printing, or sputtering. The second water-blocking layer 120 is used to block water and oxygen, which can improve the encapsulation and water and oxygen resistance of the photomedical device and extend its lifespan.

[0071] In some embodiments of this application, such as Figure 9 As shown, the insulating layer of the encapsulation layer 50 near the optical functional layer includes a second water-blocking layer 120 and a barrier adhesive layer 130; the barrier adhesive layer is composed of at least one of polyolefin and rubber; the barrier adhesive layer is doped with a water-absorbing material, such as calcium oxide or barium oxide.

[0072] In some embodiments of this application, the positive electrode layer is made of ITO and / or IZO, and the optical functional layer comprises a hole injection layer, a hole transport layer, an electron blocking layer, a light emitting layer, a hole blocking layer, and an electron blocking layer stacked sequentially; the negative electrode layer is made of Ag and / or Al.

[0073] In some embodiments of this application, such as Figure 10-11As shown, the drug layer partially covers the light-emitting side of the phototherapy device; the drug layer 60 adopts a grid-like or graphic design, allowing more light from the phototherapy device to shine out from the gaps in the drug layer, further improving the phototherapy effect.

[0074] The above description is merely a preferred embodiment of this application and an explanation of the technical principles employed. Those skilled in the art should understand that the scope of the invention involved in this application is not limited to technical solutions formed by specific combinations of the above-described technical features, but should also cover other technical solutions formed by arbitrary combinations of the above-described technical features or their equivalents without departing from the inventive concept. For example, technical solutions formed by substituting the above features with (but not limited to) technical features with similar functions disclosed in this application.

Claims

1. A multifunctional integrated photomedical device, characterized in that: The photomedical device includes: Optical functional layer; Two main electrode layers with opposite polarities are located on both sides of the optical functional layer; The drug layer is located on the light-emitting side of the photomedical device; The electrode is introduced and attached to the phototherapy tissue; Either a main electrode layer and a drug layer are located on opposite sides of a substrate layer, and an isolation layer is provided on the side of the substrate layer closest to the drug layer; or either a main electrode layer and a drug layer are located on opposite sides of an encapsulation layer, and an isolation layer is provided on the side of the encapsulation layer closest to the drug layer. The photomedical device enables the photofunctional layer to function by supplying power to two main electrode layers; the photomedical device generates an electric field for drug delivery by supplying power to either main electrode layer and the delivery electrode.

2. The multifunctional integrated photomedical device according to claim 1, characterized in that, The magnitude and / or direction of the power supply current supplied to the optical functional layer and the electric field by the photomedical device are different.

3. The multifunctional integrated photomedical device according to claim 1, characterized in that, The main electrode layer includes a first main electrode layer and a second main electrode layer; the power supply circuit of the photomedical device includes a first power supply terminal and a second power supply terminal with opposite polarities, the first power supply terminal is used to connect to the first main electrode layer, and the second power supply terminal is alternately connected to the second main electrode layer and the induction electrode through a control circuit.

4. The multifunctional integrated photomedical device according to claim 3, characterized in that, The power supply circuit is powered by an alternating positive and negative pulse power supply.

5. The multifunctional integrated photomedical device according to any one of claims 1-4, characterized in that, The drug layer is a gel doped with a drug.

6. The multifunctional integrated photomedical device according to any one of claims 1-4, characterized in that, The isolation layer is made of at least one of indium tin oxide coating or aerogel; the isolation layer is doped with scattering particles.

7. The multifunctional integrated photomedical device according to any one of claims 1-4, characterized in that, Each main electrode layer and drug layer are located on opposite sides of the substrate layer; a first water-blocking layer is provided on the side of the substrate layer closest to the main electrode layer; the first water-blocking layer is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin or polyolefin; the water-blocking layer is prepared by at least one of ALD, PECVD, IJP, screen printing or sputtering.

8. The multifunctional integrated photomedical device according to any one of claims 1-4, characterized in that, The photomedical device includes an encapsulation layer, and a second water-blocking layer is provided on the side of the encapsulation layer near the photofunctional layer. The second water-blocking layer is composed of at least one of silicon nitride, silicon oxide, silicon oxynitride, epoxy resin, or polyolefin. The water-blocking layer is prepared by at least one of ALD, PECVD, IJP, screen printing, or sputtering.

9. The multifunctional integrated photomedical device according to any one of claims 1-4, characterized in that, The photomedical device includes an encapsulation layer, and a barrier adhesive layer is provided on the side of the encapsulation layer near the photofunctional layer. The barrier adhesive layer is composed of at least one of polyolefin and rubber; the barrier adhesive layer is doped with a water-absorbing material.

10. The multifunctional integrated photomedical device according to any one of claims 1-4, characterized in that, The drug layer partially covers the light-emitting side of the photomedical device.

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