A method for the continuous synthesis of acyl chloride products

By using amide catalysts and pyridine auxiliaries in a continuous flow reactor for acyl chloride reaction, the problems of long synthesis time and low yield of acyl chloride have been solved, realizing efficient and safe continuous production of acyl chloride, which is suitable for industrial application.

CN114956990BActive Publication Date: 2026-06-26SHANGHAI HYBRID CHEM TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI HYBRID CHEM TECH
Filing Date
2021-02-26
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Existing acyl chloride synthesis processes have long reaction times, low yields, and are difficult to achieve large-scale continuous production. Existing continuous synthesis equipment has large footprints, high energy consumption, and complex processes.

Method used

In a continuous flow reactor, amide catalysts and/or pyridine are used as auxiliaries to carry out acyl chlorination reactions with organic acids and thionyl chloride. The reaction temperature is controlled at 50–160 °C, the pressure at 2–15 bar, and the time at 20–300 s. Microreactors, tubular reactors, and other equipment are used for the acyl chlorination reaction.

Benefits of technology

The reaction time is significantly shortened, energy consumption is reduced, operation is simple, stability is high, conversion rate and selectivity are high, side reactions are few, product yield is high, and post-processing is simple, making it suitable for continuous industrial production.

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Abstract

The application discloses a kind of continuous synthesis methods of acid chloride product.It includes the following steps: in continuous flow reactor, under the action of amide catalyst and / or pyridine, organic acid and thionyl chloride are acylchlorinated reaction;Reaction temperature is 50-160 DEG C;Reaction pressure is 2-15 bar;Reaction time is 20-300 s.The application overcomes the defect that the mass transfer and heat transfer performance of kettle type reactor is poor, and the reaction can run smoothly, the reaction time is greatly shortened, energy consumption is reduced, cost is saved;Simple operation, high stability, can realize high automation, reduce human interference and error, continuous production can be realized;Liquid volume in reactor is small, which can effectively avoid the generation of hot spot in the exothermic reaction;High conversion rate, high selectivity, less side reaction, crude product has no other impurities, high yield, simple post-treatment, easy to separate;Industrial amplification process has almost no amplification effect.
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