Automated analysis device

Abstract

This invention provides an automated analytical apparatus for reagent dispensing where the lid of the reagent container does not obstruct reagent dispensing. An automated analytical apparatus for analyzing samples is characterized by comprising: a reagent dispensing unit that dispenses reagents from reagent bottles containing a plurality of reagent containers arranged in one direction, the plurality of reagent containers holding reagents used in the analysis of the sample; a reagent rack that holds the reagent bottles, the reagent rack having a lid opening portion that opens a lid corresponding to an upward opening of the reagent container along the arrangement direction of the reagent containers; and a lid fixing portion that fixes the lid outside the path through which it is inserted into the reagent dispensing unit.

Description

Technical Field

[0001] This invention relates to an automatic analysis device. Background Technology

[0002] An automated analytical apparatus is a device used to automatically perform quantitative or qualitative analysis of specific components in samples such as blood and urine. Various reagents are used in the analysis of samples by an automated analytical apparatus. To obtain stable analytical results, it is necessary to prevent reagent concentration due to evaporation and drying, and reagent deterioration due to the introduction of dust or other contaminants. Therefore, the reagents used for analysis are contained in reagent containers with lids that can be opened and closed, and the lids of the reagent containers are opened and closed as needed. Furthermore, in most cases, multiple reagent containers with upward-facing openings are arranged in one direction, and the lids corresponding to each opening open and close along the arrangement direction of the reagent containers.

[0003] Patent document 1 discloses an automatic analysis device that enables multiple covers that can be opened and closed around a hinge to change from a closed state to a half-open state or from a half-open state to a closed state, or from a half-open state to an open state or from an open state to a half-open state.

[0004] Existing technical documents

[0005] Patent documents

[0006] Patent Document 1: Japanese Patent Application Publication No. 2017-75789 Summary of the Invention

[0007] The problem that the invention aims to solve

[0008] However, in Patent Document 1, the open cap sometimes hinders reagent dispensing. That is, because an over-open cap covers the opening of an adjacent container, and an under-open cap covers the corresponding opening, the cap of the reagent container sometimes blocks the path to the dispensing part inserted into the opening during reagent dispensing.

[0009] Therefore, the object of the present invention is to provide an automated analytical device for dispensing reagents in which the lid of the reagent container does not obstruct the dispensing of reagents.

[0010] Solution for solving the problem

[0011] To achieve the above objectives, the present invention provides an automatic analysis apparatus for analyzing samples, characterized by comprising: a reagent dispensing unit that dispenses the reagent from reagent bottles containing a plurality of reagent containers arranged in one direction, the plurality of reagent containers holding the reagents used in the analysis of the sample; and a reagent rack that holds the reagent bottles, the reagent rack having: a lid opening portion that opens a lid corresponding to the upward opening of the reagent containers along the arrangement direction of the reagent containers; and a lid fixing portion that fixes the lid outside the path through which it is inserted into the reagent dispensing unit.

[0012] Furthermore, the present invention provides an automatic analysis device for analyzing samples, characterized in that it comprises: a reagent dispensing unit that dispenses the reagent from a reagent bottle containing a plurality of reagent containers arranged in one direction, the plurality of reagent containers containing the reagent used in the analysis of the sample; a reagent rack that holds the reagent bottles; and a cap support that, in conjunction with the downward movement of the reagent rack, opens a cap corresponding to an upward opening of the reagent container along the arrangement direction of the reagent containers, and maintains the cap in an open state.

[0013] The effects of the invention are as follows.

[0014] According to the present invention, it is possible to provide an automated analytical device for dispensing reagents with a lid that does not obstruct the dispensing of reagents. Attached Figure Description

[0015] Figure 1 This is a simplified diagram of the overall structure of the automatic analysis device.

[0016] Figure 2 This is a three-dimensional diagram of the support tray inside the reagent sample storage section.

[0017] Figure 3A This is a diagram showing a reagent bottle with the cap closed.

[0018] Figure 3B This is a diagram showing a reagent bottle with the cap open.

[0019] Figure 4A This is a 3D schematic diagram of the reagent rack.

[0020] Figure 4B This is a 3D diagram of the reagent rack after inserting a reagent bottle with its cap closed.

[0021] Figure 4C This is a 3D diagram of a reagent rack with the reagent bottle caps open.

[0022] Figure 5A This is a diagram showing a reagent rack in front of a reagent bottle with its cap closed.

[0023] Figure 5B This is a diagram showing a reagent rack after inserting a reagent bottle with its cap closed.

[0024] Figure 5C This diagram shows the state after the cover is opened as the cover support moves upward.

[0025] Figure 6 This is a diagram of a reagent rack when the reagent bottle is inserted in the wrong direction.

[0026] Figure 7 This is a diagram showing the support tray after the reagent rack containing the reagent bottles has been inserted.

[0027] Figure 8A This is a top view showing an example of a cover guide section.

[0028] Figure 8B This is a cross-sectional view showing an example of a cover guide section.

[0029] Figure 8C This is a cross-sectional view showing an example of a cover guide section.

[0030] Figure 9A This is a top view showing another example of a cover guide section.

[0031] Figure 9B This is a cross-sectional view showing another example of a cover guide section.

[0032] Figure 9C This is a cross-sectional view showing another example of a cover guide section.

[0033] Figure 10A This is a top view showing another example of a cover guide section.

[0034] Figure 10B This is a cross-sectional view showing another example of a cover guide section. Detailed Implementation

[0035] Hereinafter, preferred embodiments of the automatic analysis apparatus of the present invention will be described with reference to the accompanying drawings. In the following description and drawings, components having the same functional structure are labeled with the same reference numerals, and repeated descriptions are omitted. Furthermore, the drawings schematically illustrate embodiments, sometimes simplifying real-world objects for illustration.

[0036] Example 1

[0037] use Figure 1 This describes an example of the overall structure of an automated analytical device that automatically performs quantitative or qualitative analysis on specific components contained in samples such as blood and urine. The automated analytical device includes a reagent / sample storage section 3, a constant temperature chamber 1, a reagent dispensing section 8, a sample dispensing section 9, an analysis section 10, a transport section 11, a waste container 15, and a control section 18.

[0038] The reagent sample storage section 3 stores reagent bottles 4 and sample containers 5, and maintains them at a predetermined temperature. Inside the reagent sample storage section 3, there is a support tray 20 that divides the space for storing the reagent bottles 4 and sample containers 5. Figure 2 The support tray 20 is described in detail below. Reagent vials 4 hold multiple reagents for analysis. Use Figure 3A and Figure 3B The reagent bottle 4 will be described in detail below. The sample container 5 holds samples such as blood and urine. A reagent aspiration hole 6 and a sample aspiration hole 7 are provided on the upper surface of the reagent sample storage section 3. Reagent contained in the reagent bottle 4 is drawn through the reagent aspiration hole 6, and the sample contained in the sample container 5 is drawn through the sample aspiration hole 7. Inside the reagent sample storage section 3, the support tray 20 is rotated, thereby positioning the reagent bottle 4 and sample container 5 below the reagent aspiration hole 6 and sample aspiration hole 7, respectively.

[0039] The incubator 1 maintains a constant temperature for the reaction vessel 2, which is positioned on its circumference. Rotation moves the reaction vessel 2 to a predetermined position. An empty reaction vessel 2, positioned in the incubator 1, is transferred from the container tray 14 by the conveying unit 11. Reagents and samples are dispensed from the reagent / sample receiving unit 3 into the empty reaction vessel 2 by the reagent dispensing unit 8 and the sample dispensing unit 9. More specifically, the reagent dispensing unit 8... Figure 1 The sample dispenser moves along the arc shown by the dashed line, inserts into reagent bottle 4 to draw a predetermined amount of reagent, and dispenses the reagent into empty reaction vessel 2. Then, the sample dispenser 9 also moves along the arc shown by the dashed line, draws a predetermined amount of sample from sample container 5, and dispenses the sample into reaction vessel 2 after the reagent has been dispensed. The reagent and sample dispensed into reaction vessel 2 are maintained at a constant temperature, thereby generating a reaction, and the results of the reaction are analyzed by analysis unit 10.

[0040] Furthermore, to prevent sample contamination, the dispensing pipette tip 12 can be replaced each time a sample is dispensed from the sample dispensing unit 9. The dispensing pipette tip 12 is conveyed by the transport unit 11 from the pipette tip tray 13 to the pipette tip assembly position 16 located on the upper surface of the waste container 15, and is then assembled into the sample dispensing unit 9 at the pipette tip assembly position 16. After sample dispensing, the dispensing pipette tip 12 is discarded into the waste port 17 provided in the waste container 15. The analysis reaction vessel 2 is also discarded into the waste port 17.

[0041] The control unit 18 controls the operation of each part described above, such as the CPU (Central Processing Unit). That is, the control unit 18 controls the rotation of the reagent sample storage unit 3 and the constant temperature chamber 1, the temperature control, the dispensing operation of the reagent dispensing unit 8 and the sample dispensing unit 9, the analysis operation of the analysis unit 10, and the conveying operation of the conveying unit 11, etc.

[0042] use Figure 2 An example of a support tray 20 will be described. The support tray 20 has a circular plate portion 21, a cylindrical portion 22, a cylindrical portion 23, an inner partition wall 24, and an outer partition wall 25. The circular plate portion 21 is a plate with a circular shape, and may also have an opening. The cylindrical portion 22 is a cylindrical component with a cylindrical shape concentric with the circular plate portion 21, disposed on the circular plate portion 21, and having an outer diameter smaller than the outer diameter of the circular plate portion 21. The cylindrical portion 23 is a cylindrical component with a cylindrical shape concentric with the circular plate portion 21, disposed on the circular plate portion 21, and having an outer diameter smaller than the outer diameter of the cylindrical portion 22 and a height lower than the height of the cylindrical portion 22.

[0043] The inner partition 24 is a plate that equally divides the space between the cylindrical portion 22 and the cylindrical portion 23 in the circumferential direction. A reagent rack 40 for holding multiple reagent bottles 4 is housed in the space enclosed by two circumferentially adjacent inner partitions 24 and the cylindrical portion 22. Each space housing the reagent rack 40 has one or more ribs 26 and one or more inner pins 27. The ribs 26 are located on the inner circumferential surface of the cylindrical portion 22, extending axially from the upper surface of the circular plate portion 21, allowing a portion of the reagent rack 40 to slide. The inner pins 27 are located on the upper surface of the circular plate portion 21 and are positioned further inward than the cylindrical portion 22, serving to position the reagent rack 40 by engaging with it. Figure 2 In the support tray 20, six inner partitions 24 are arranged radially from the cylindrical part 23 to the cylindrical part 22, which can accommodate six reagent racks 40.

[0044] The outer partition 25 is a plate that equally divides the space between the cylindrical portion 22 and the circular plate portion 21 in the circumferential direction. A sample holder 41 for holding multiple sample containers 5 is housed in the space enclosed by the two circumferentially adjacent outer partitions 25, the cylindrical portion 22, and the circular plate portion 21. Each space housing the sample holder 41 has one or more outer pins 28. The outer pins 28 are located on the upper surface of the circular plate portion 21 and are positioned further outward than the cylindrical portion 22, and are used for positioning the sample holder 41 by engaging with it.

[0045] use Figure 3A and Figure 3B An example of reagent bottle 4 will be explained. Figure 3A and Figure 3B The image includes a front view of reagent bottle 4, as well as two side views and a top view. Reagent bottle 4 is constructed by integrating multiple reagent containers 30 into a single housing 33. Each of the multiple reagent containers 30 has an upward-facing opening 36 and a cap 31 that seals the opening 36, and they are arranged in one direction. Figure 3A The reagent bottle 4 is shown with all three caps 31 closed. Figure 3B The reagent bottle 4 is shown with its three caps 31 open.

[0046] The lid 31 is connected to the reagent container 30 via a hinge 35, and opens and closes about the hinge 35 along the direction in which the reagent containers 30 are arranged. The lid 31 has a protrusion 32 for use in opening and closing the lid. The protrusion 32, for example, protrudes in a direction orthogonal to the opening and closing direction of the lid 31, and has a cylindrical shape. The closed lid 31 seals the opening 36, thereby preventing the reagent contained in the reagent container 30 from evaporating, drying, or contaminating with dust. Furthermore, when dispensing reagent, the reagent dispensing part 8 is inserted into the reagent container 30 through the opening 36 after the lid 31 is opened, and draws in the reagent.

[0047] Alternatively, an IC tag 34 for data management of the reagent bottle 4 can be affixed to the housing 33. Data related to the reagent bottle 4 can be recorded on the IC tag 34, as well as an identifier used to identify the reagent bottle 4. When the identifier is recorded on the IC tag 34, the data related to the reagent bottle 4 is associated with the identifier and stored in a storage unit accessible by the control unit 18. Furthermore, the operator can determine the orientation of the reagent bottle 4 based on the location where the IC tag 34 is affixed.

[0048] However, if the over-opened cap 31 covers the adjacent opening 36, or if the under-opened cap 31 covers the corresponding opening 36, it will be impossible to insert the reagent dispensing section 8 into the reagent container 30, thus causing inconvenience in reagent dispensing. Therefore, in this embodiment, a cap fixing part is provided in the reagent rack 40 to fix the cap 31 of the reagent container 30 outside the path of the reagent dispensing section 8, so as not to hinder reagent dispensing.

[0049] use Figures 4A to 4C An example of reagent rack 40 is described below. Figure 4A A three-dimensional schematic diagram of reagent rack 40 monomers is shown. Figure 4B The reagent rack 40 is shown after the reagent bottle 4 with its cap 31 closed. Figure 4C The reagent rack 40 is shown with the lid 31 of reagent bottle 4 open. The reagent rack 40 has a handle 42, a lid support 43, and a bottle storage section 44.

[0050] The handle 42 is the part held by the operator for moving the reagent rack 40, and is connected to the bottle storage part 44 by two fixed rotating shafts 45.

[0051] The bottle storage section 44 has a plurality of partition walls 54 and a bottom surface 56 arranged radially, and the reagent bottle 4 is stored in the space enclosed by two adjacent partition walls 54 and bottom surfaces 56. Figures 4A to 4C It is equipped with seven partition walls 54, which can accommodate six reagent bottles 4. The bottom surface 56 is provided with a positioning hole 57 for the inner pin 27 to fit in and a rib passage groove 58 for the rib 26 to pass through.

[0052] Each partition wall 54 is provided with a leaf spring 55, which has a shape that protrudes from the surface of the partition wall 54 and is capable of displacement along the concave and convex parts of the side of the reagent bottle 4. The leaf spring 55 is engaged with the concave part of the reagent bottle 4 to fix the position of the reagent bottle 4. That is, to prevent the reagent bottle 4 from falling off the reagent rack 40 due to its own weight when the reagent rack 40 is moved, or to prevent the reagent bottle 4 from floating up from the bottle storage part 44.

[0053] The cap support 43 is disposed between the handle 42 and the bottle storage portion 44, and is movable along the fixed axis 45. It has a contact portion 50 and multiple cap guide portions 51. A sliding shaft 46 may also be connected to the cap support 43. This sliding shaft 46 is slidable relative to the bottle storage portion 44 and serves as a guide for the vertical movement of the cap support 43. Furthermore, a step may be provided at the lower end of the sliding shaft 46 to limit the range of movement of the cap support 43.

[0054] The contact portion 50 is configured to contact the upper surface of the cylindrical portion 23 when the reagent rack 40 is housed in the support tray 20. That is, when the reagent rack 40 is housed in the support tray 20, contacting the contact portion 50 with the upper surface of the cylindrical portion 23 allows the cover support portion 43 to move upward.

[0055] The cap guide portion 51 is located above each of the partition walls 54. When the reagent rack 40 is stored in the support tray 20, the lower surface of the cap guide portion 51 contacts the upper surface of the rib 26. That is, when the reagent rack 40 is stored in the support tray 20, the lower surface of the cap guide portion 51 contacts the upper surface of the rib 26, which also allows the cap support portion 43 to move upward. Adjacent cap guide portions 51 are arranged at the same distance as the outer diameter of the opening 36 of the reagent container 30 and are connected by a semi-circular portion 51A. The semi-circular portion 51A has the same shape as the side of the opening 36 of the reagent container 30 to prevent the reagent bottle 4 from being inserted backwards. Figure 6 The semi-circular portion 51A will be described in detail below.

[0056] Furthermore, each of the cap guide portions 51 has a ramp 52 and a limiting member 53 on its upper surface. The ramp 52 is an inclined surface that allows the protrusion 32 of the cap 31 to slide when the cap support portion 43 moves upward, serving as the cap opening portion of the cap 31 for opening the reagent container 30. The limiting member 53 is a wall surface that is vertically arranged relative to the ramp 52, serving as a cap fixing portion that secures the cap 31 outside the path of the reagent dispensing portion 8. That is, by moving the cap support portion 43 upward, the cap 31 of the reagent container 30 is opened and secured outside the path of the reagent dispensing portion 8. Figures 8A to 8C , Figures 9A to 9C , Figure 10A and Figure 10B The ramp 52 and the limiting element 53 are described in detail below.

[0057] use Figures 5A to 5C The action of opening the lid 31 of the reagent container 30 from the reagent rack 40 will be explained. Furthermore, Figure 5A The reagent holder 40 is shown in front of the reagent bottle 4 with the insert cap 31 closed. Figure 5B The reagent rack 40 is shown after the reagent bottle 4 with its cap 31 closed. Figure 5C The top view and AA cross-sectional view show the reagent rack 40 with the lid 31 of reagent bottle 4 open.

[0058] like Figure 5A As shown, a reagent bottle 4 with its cap 31 closed is inserted into the reagent rack 40 from the outer periphery. During the insertion of the reagent bottle 4, the leaf spring 55 moves along the concave and convex sides of the reagent bottle 4. If the side of the opening 36 of the reagent container 30 enters the semi-circular portion 51A, the leaf spring 55 engages with the concave portion of the side of the reagent bottle 4 to fix the position of the reagent bottle 4. When the reagent bottle 4 is fixed in the reagent rack 40, if... Figure 5B As shown, the protrusion 32 is located at the uppermost part of the ramp 52, and the cap 31 remains closed. With the reagent bottle 4 fixed to the reagent rack 40, if the reagent rack 40 is inserted into the support tray 20, the contact portion 50 contacts the upper surface of the cylindrical portion 23, and the lower surface of the cap guide portion 51 contacts the rib 26. If the reagent rack 40 is further inserted into the support tray 20, the cap support portion 43 moves upward. Due to the upward movement of the cap support portion 43, the protrusion 32 is pushed upward while sliding on the surface of the ramp 52, such as... Figure 5C As shown, the cover 31 is opened. After opening, the cover 31 is fixed outside the path of the reagent dispensing section 8 by the limiting member 53.

[0059] use Figure 6 The case where reagent bottle 4 is inserted into reagent rack 40 in the opposite direction will be explained. When reagent bottle 4 is inserted in the correct direction, as follows... Figure 5B As shown, the side of the opening 36 of the reagent container 30 enters the semi-circular portion 51A. In contrast, when the reagent bottle 4 is inserted in the reverse direction, the shape of the part of the reagent bottle 4 connected to the hinge 35 is inconsistent with the semi-circular portion 51A, and the reagent bottle 4 extends out of the reagent rack 40. With the reagent bottle 4 extending out of the reagent rack 40, the support tray 20 cannot be inserted into the reagent rack 40, thus preventing the reverse insertion of the reagent bottle 4.

[0060] use Figure 7 The state after inserting the reagent rack 40 containing the reagent bottle 4 into the support tray 20 is described. Figure 7These are top views and BB sectional views of the support tray 20 into which the reagent rack 40 is inserted. If the operator holds the handle 42 and inserts the reagent rack 40 from above the support tray 20, the cylindrical portion 23 pushes the contact portion 50 upwards, and the rib 26 pushes the cover guide portion 51 upwards, causing the cover guide portion 51 to move upwards. As the cover guide portion 51 moves upwards, the protrusion 32 slides on the surface of the ramp 52, and the cover 31 opens.

[0061] use Figures 8A to 8C An example of ramp 52 and limit member 53 will be described. Figure 8A This is a top view of the cover guide section 51. Figure 8B and Figure 8C yes Figure 8A The CC sectional view. The ramp 52 has a cross-sectional shape formed along the trajectory of the protrusion 32 when the cover 31 is opened, for example, it could also be... Figure 8B The combination of multiple inclined planes with different inclinations shown, or Figure 8C The surface shown includes a smooth curve. Because the ramp 52 has a cross-sectional shape formed along the trajectory of the protrusion 32, when the protrusion 32 is at its lowest point, the cover 31 will not be under-opened, preventing the cover 31 from covering the corresponding opening 36. Furthermore, because the cross-sectional shape of the ramp 52 includes a smooth curve, the sliding of the protrusion 32 becomes smooth. Moreover, because the protrusion 32 contacts the limiting member 53, the cover 31 will not be over-opened, preventing adjacent openings 36 from being covered by the cover 31.

[0062] use Figures 9A to 9C Another example of ramp 52 and limit member 53 will be described. Figure 9A This is a top view of the cover guide section 51. Figure 9B and Figure 9C yes Figure 9A A CC cross-sectional view. The height h of the ramp 52 from the bottom surface to the top surface is preferably greater than the outer diameter d of the protrusion 32. By setting h > d, the protrusion 32 is less likely to detach from the space enclosed by the ramp 52 and the limiting member 53, thus suppressing excessive opening of the cover 31. Furthermore, the limiting member 53 preferably has a surface with an angle of right angle or greater with the bottom surface of the ramp 52. For example, in Figure 9B In the middle, the upper end of the limiting member 53, which is erected vertically in the vertical direction, has an inclined surface 53A. Figure 9C In the middle, the limiting member 53 is tilted upward so that the limiting member 53 has a surface that forms an angle of more than a right angle with the bottom surface of the slope 52, so that when the reagent bottle 4 is taken out from the reagent rack 40, the protrusion 32 will not be stuck by the upper end of the limiting member 53.

[0063] use Figure 10A and Figure 10B Another example of ramp 52 and limit member 53 will be described. Figure 10AThis is a top view of the cover guide section 51. Figure 10B yes Figure 10A A CC sectional view. A groove 52A for engaging the protrusion 32 can also be provided between the ramp 52 and the limiting member 53. By engaging the protrusion 32 with the groove 52A, the opening and closing of the cover 31 can be suppressed.

[0064] The embodiments of the present invention have been described above. The present invention is not limited to the above embodiments, and the constituent elements can be modified without departing from the spirit of the invention. Furthermore, the multiple constituent elements disclosed in the above embodiments can be appropriately combined. Moreover, several constituent elements can be deleted from all the constituent elements shown in the above embodiments. For example, the sample holder 41 can be stored in another storage section instead of the support tray 20, and samples can be dispensed from there.

[0065] Symbol Explanation

[0066] 1—Incubator, 2—Reaction vessel, 3—Reagent / sample storage section, 4—Reagent bottle, 5—Sample container, 6—Reagent aspiration port, 7—Sample aspiration port, 8—Reagent dispensing section, 9—Sample dispensing section, 10—Analytical section, 11—Transport section, 12—Dispensing pipette tip, 13—Pipette tip tray, 14—Container tray, 15—Waste bin, 16—Pipette tip assembly position, 17—Waste hole, 18—Control section, 20—Support tray, 21—Circular plate section, 22—Cylinder section, 23—Cylindrical section, 24—Inner partition wall, 25—Outer partition wall, 26—Rib, 27—Inner 28—Side pin, 30—Reagent container, 31—Cap, 32—Protrusion, 33—Housing, 34—IC tag, 35—Hinge, 36—Opening, 40—Reagent rack, 41—Sample rack, 42—Handle, 43—Cap support, 44—Bottle storage, 45—Fixed shaft, 46—Sliding shaft, 50—Contact part, 51—Cap guide, 51A—Semi-circular part, 52—Slope, 52A—Groove, 53—Limiting element, 53A—Inclined surface, 54—Separator wall, 55—Leaf spring, 56—Bottom surface, 57—Positioning hole, 58—Rib through groove.

Claims

1. An automatic analysis device for analyzing samples, characterized in that, have: A reagent dispensing unit dispenses the reagents from reagent bottles containing multiple reagent containers arranged in one direction, the multiple reagent containers holding reagents used in the analysis of the sample; and The reagent rack stores the aforementioned reagent bottles. The reagent rack described above has: a bottle storage section having a plurality of partition walls and a bottom surface arranged radially; a cap support section having a plurality of cap guide sections provided above each of the plurality of partition walls; and a cap opening section that opens a cap corresponding to an upward opening of the reagent container along the arrangement direction of the reagent container. The cap fixing part secures the cap outside the path through which the reagent dispensing part is inserted into the opening. The aforementioned cover has a protrusion that extends in a direction orthogonal to the direction in which the cover opens. The aforementioned opening portion of the cap is a ramp provided on the upper surface of each of the plurality of cap guide portions. When the cap support portion moves upward by inserting the reagent holder containing the reagent bottle with the aforementioned protrusion located at the uppermost part of the aforementioned ramp and the aforementioned cap remaining closed from above the support tray, the aforementioned protrusion slides on the surface of the aforementioned ramp and opens the aforementioned cap. The aforementioned cover fixing part is a wall surface provided on the upper surface of each of the aforementioned cover guide parts and erected relative to each of the aforementioned slopes. The aforementioned wall surface has a surface that forms a right angle or more with the bottom surface of each of the aforementioned slopes.

2. The automatic analysis device according to claim 1, characterized in that, The aforementioned slope has a cross-sectional shape formed along the trajectory of the aforementioned protrusion when the aforementioned cover is opened.

3. The automatic analysis device according to claim 2, characterized in that, The cross-sectional shape of the aforementioned slope includes a smooth curve.

4. The automatic analysis device according to claim 1, characterized in that, The height of the aforementioned slope from its bottom surface to the top surface of the aforementioned reagent rack is greater than the outer diameter of the aforementioned protrusion.

5. The automatic analysis device according to claim 1, characterized in that, A groove is provided between the aforementioned slope and the aforementioned wall surface for the aforementioned protrusion to fit together.

6. The automatic analysis device according to claim 1, characterized in that, The reagent rack also has a reverse insertion prevention part that prevents the storage of the reagent bottle when it is not inserted from a predetermined direction.

7. The automatic analysis device according to claim 6, characterized in that, The reagent rack also has a leaf spring that engages with a recess on the side of the reagent bottle when inserted from a predetermined direction to hold the reagent bottle.

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