Automatic analysis system, control device and cleaning method

Abstract

In order to obtain highly reliable measurement results, the present invention is characterized in that it comprises: an automatic analysis device (100) and a control unit (200), the automatic analysis device (100) having a sample probe (122) for sucking and discharging the sample, and a sample dispensing unit (121) for moving the sample probe (122) at least from the position of a sample container (152) containing the sample to the position of a reaction container (131) into which the sample is dispensed, and a sample probe cleaning unit (110) for performing a first cleaning of discharging cleaning water around the sample probe (122) between sucking the sample from the sample container (152) and discharging the sample into the reaction container (131), and the controller (200) controls the discharge and stop of the cleaning water in the first cleaning in a specified inspection item.

Description

Technical Field

[0001] The present invention relates to technologies for an automatic analysis system, a control device, and a cleaning method for performing spectroscopic measurement of a specimen. Background Art

[0002] In blood and urine tests, the sample probe used to dispense the sample is cleaned and then inserted a predetermined distance into the sample. The sample probe then aspirates the sample and discharges it into a reaction vessel. Reagents are then dispensed into the reaction vessel, stirring the sample. The absorbance of the stirred sample is typically measured.

[0003] Patent document 1 discloses an automatic analysis system and an inspection system, which is characterized in that an automatic analysis device dispenses the sample of the upper layer from a sample container containing a sample separated into an upper layer and a lower layer by a separation process of a test sample, and analyzes a predetermined inspection item by measuring a mixed solution of the upper layer sample and a reagent, wherein the automatic analysis device comprises: a dispensing probe for sucking the upper layer sample in the sample container from the lower end and dispensing it into a reaction container; a detector for detecting contact between the upper layer sample in the sample container and the lower end of the dispensing probe; and an acquisition unit for acquiring an analysis value of a predetermined component contained in the test sample before being separated into the upper layer and the lower layer and affecting the inspection item inspected using the upper layer sample. "; and a drive control unit that lowers the dispensing probe into the sample container and stops the lower end of the dispensing probe at at least two different positions in the upper sample based on the analysis value and the detection signal detected by the detector, wherein, when the analysis value is below a predetermined upper limit, the drive control unit stops the dispensing probe at a first suction position in the upper sample that is a first distance below the position where the lower end of the dispensing probe contacts the upper sample, and when the analysis value exceeds the upper limit, the drive control unit stops the dispensing probe at a second suction position in the upper sample that is below the first suction position." (See claim 1).

[0004] Prior art literature

[0005] Patent Literature

[0006] Patent Document 1: Japanese Patent No. 5931540 Summary of the Invention

[0007] Problems to be solved by the invention

[0008] In the case of a blood test, the specimen (plasma, serum, etc.) measured by the automated analysis system is collected using a vacuum blood collection tube and then centrifuged. The serum and plasma of the centrifuged specimen are then analyzed. It is known that in the centrifuged specimen, only the measurement results of a specific item contain unstable components (hereinafter referred to as unstable components). Furthermore, it is known that such unstable components are present near the supernatant of the centrifuged specimen.

[0009] As described in Patent Document 1, when the specimen is aspirated, if the amount of insertion of the specimen probe into the specimen is deepened (increased), the unstable components present near the supernatant will not be attracted into the specimen probe. However, when the specimen probe is pulled out of the specimen after aspiration, the unstable components will adhere to the side of the specimen probe in any case. If the unstable components are attached to the side of the specimen probe, the specimen will be discharged in a manner that bypasses the side of the specimen probe when the specimen is discharged into the reaction container. Therefore, unstable components are mixed into the discharged specimen (details will be described later). As a result, there is a problem that stable measurement results cannot be obtained.

[0010] The present invention has been made in view of such a background, and an object of the present invention is to obtain highly reliable measurement results.

[0011] Means for solving problems

[0012] In order to solve the above-mentioned problem, the present invention is characterized in that it comprises: an automatic analysis unit and a control unit, the automatic analysis unit comprises: a probe unit which aspirates and discharges the specimen; and a cleaning unit which comprises a probe moving unit which moves the probe unit at least from the position of a specimen container containing the specimen to the position of a reaction container into which the specimen is dispensed, and performs a first cleaning, wherein the first cleaning is to discharge a cleaning liquid around the probe unit between aspirating the specimen from the specimen container and discharging the specimen into the reaction container, and the control unit controls the discharge and stopping of the cleaning liquid in the first cleaning in a specified inspection item.

[0013] Other solutions will be described appropriately in the embodiments.

[0014] Effects of the Invention

[0015] According to the present invention, highly reliable measurement results can be obtained. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a configuration diagram of the automatic analysis system according to the first embodiment.

[0017] Figure 2A This is a diagram (part 1) showing a top view of the sample probe cleaning unit.

[0018] Figure 2B This is a perspective view of the specimen probe cleaning unit (part 1).

[0019] Figure 2C This is a cross-sectional view of the sample probe cleaning unit (part 1).

[0020] Figure 3A This is a diagram (part 2) showing a top view of the sample probe cleaning unit.

[0021] Figure 3B This is a perspective view of the specimen probe cleaning unit (part 2).

[0022] Figure 3C This is a cross-sectional view of the specimen probe cleaning unit (part 2).

[0023] Figure 4A This is a diagram showing the problems of the methods so far (part 1).

[0024] Figure 4B This is a diagram (part 2) showing the problems of the methods thus far.

[0025] Figure 4C This is a diagram (part 3) showing the problems of the methods so far.

[0026] Figure 4D This is a diagram (part 4) showing the problems of the methods thus far.

[0027] Figure 4E This is a diagram (part 5) showing the problems of the methods so far.

[0028] Figure 4F This is a diagram (part 6) showing the problems of the methods so far.

[0029] Figure 5A This is a diagram (part 1) for explaining the method of midway cleaning in this embodiment.

[0030] Figure 5B This is a diagram (part 2) for explaining the method of midway cleaning in this embodiment.

[0031] Figure 5C This is a diagram (part 3) for explaining the method of midway cleaning in this embodiment.

[0032] Figure 5D This is a diagram (part 4) for explaining the method of midway cleaning in this embodiment.

[0033] Figure 5E This is a diagram (part 5) for explaining the method of midway cleaning in this embodiment.

[0034] Figure 5FThis is a diagram (part 6) for explaining the method of midway cleaning in this embodiment.

[0035] Figure 5G FIG. 7 is a diagram for explaining the method of midway cleaning in this embodiment.

[0036] Figure 5H FIG. 8 is a diagram for explaining the method of midway cleaning in this embodiment.

[0037] Figure 6 It is a diagram showing a timing chart during the second cleaning.

[0038] Figure 7 FIG. 1 is a diagram showing a timing chart of the first cleaning in the first embodiment.

[0039] Figure 8 This is a diagram showing the temporal change in the rotation speed of the sample probe during the first cleaning in the first embodiment.

[0040] Figure 9 It is a diagram showing a timing chart of the first cleaning in the second embodiment.

[0041] Figure 10 This is a diagram showing the temporal change in the rotation speed of the sample probe during the first cleaning in the second embodiment.

[0042] Figure 11 FIG. 1 is a diagram showing a timing chart of the first cleaning in the third embodiment.

[0043] Figure 12 This is a diagram showing the temporal change in the rotation speed of the sample probe during the first cleaning according to the third embodiment.

[0044] Figure 13 It is a diagram showing a timing chart of the first cleaning in the fourth embodiment.

[0045] Figure 14A This diagram shows a method of dividing into two cycles.

[0046] Figure 14B This is a timing chart showing the first cleaning in two cycles.

[0047] Figure 15A This diagram shows a method divided into three cycles.

[0048] Figure 15B This is a timing chart showing the first cleaning in three cycles.

[0049] Figure 16 This is a functional block diagram of the controller of this embodiment.

[0050] Figure 17It is a diagram showing the hardware configuration of the controller according to this embodiment.

[0051] Figure 18 This is a flowchart showing the procedure of the switching process between the first cleaning and the second cleaning.

[0052] Figure 19 This is a diagram showing an example of action registration data in the sixth embodiment.

[0053] Figure 20A This is a diagram (part 1) showing an example of operation sequence list data in the sixth embodiment.

[0054] Figure 20B This is a diagram (part 2) showing an example of operation sequence list data in the sixth embodiment.

[0055] Figure 20C This is a diagram (part 3) showing an example of operation sequence list data in the sixth embodiment. DETAILED DESCRIPTION

[0056] Then, refer to the attached Figure 1 Hereinafter, a mode for carrying out the present invention (referred to as “embodiment”) will be described in detail.

[0057] [First embodiment]

[0058] <System Structure>

[0059] Figure 1 It is a configuration diagram of the automatic analysis system 1 according to the first embodiment.

[0060] Figure 1 The illustrated automatic analysis system 1 includes an automatic analysis device 100 and a controller 200 .

[0061] In the automatic analyzer 100, the sample P is dispensed into each of the plurality of reaction containers 131 (see Figure 4A etc.) and reagents. Furthermore, the specimen P dispensed into the reaction container 131 reacts with the reagent. The specimen P and the reagent after the reaction are called a reaction liquid. The automatic analysis system 1 is a device for measuring the reaction liquid, and comprises: a reaction disk 130, a reagent disk 140, a specimen transport unit 151, a reagent dispensing unit 161, a reagent syringe 162, and a specimen dispensing unit 121. In addition, the automatic analysis system 1 comprises: a specimen syringe 123, a reaction container cleaning unit 171, a light source 172, a spectrophotometer 173, a stirring unit 181, a cleaning pump 174, a specimen probe cleaning unit 110, and cleaning tanks 163 and 182. The automatic analysis system 1 of this embodiment is characterized in that it comprises a specimen dispensing unit 121 and a specimen probe cleaning unit 110.

[0062] Reaction containers 131 are arranged on the circumference of the reaction disk 130. A sample transport unit 151 is provided near the reaction disk 130 to move a rack 153 carrying sample containers 152. Samples P (in this embodiment, plasma and serum P1 (see Figure 4A )).

[0063] A sample dispensing unit 121 is provided between the reaction disk 130 and the sample transport unit 151. The sample probe 122 is connected to a sample syringe 123. The sample probe 122 is driven by the sample syringe 123 to aspirate and discharge the sample P.

[0064] After the sample probe 122 aspirates the sample P from the sample container 152, it ascends through the sample dispensing unit 121 and then moves to the position of the reaction container 131 while describing an arc centered on the rotation axis. Once the sample probe 122 has reached the position of the reaction container 131, it is lowered by the sample dispensing unit 121 to dispense the sample P into the reaction container 131.

[0065] The sample probe cleaning unit 110 uses cleaning water W (see Figure 2C The outer side of the sample probe 122 is cleaned by the sample probe cleaning unit 110. There are two types of cleaning of the sample probe 122: (1) intermediate cleaning E1 (see Figure 7 (2) Post-dispensing cleaning E2 (see Figure 6 The operation of performing both the intermediate cleaning E1 and the post-dispensing cleaning E2 is referred to as the first cleaning, and the operation of performing only the post-dispensing cleaning E2 is referred to as the second cleaning. The cleaning of the sample probe cleaning unit 110 will be described later.

[0066] A plurality of reagent containers 141 can be placed on the circumference of the reagent disk 140. The reagent disk 140 is kept cool.

[0067] A reagent dispensing unit 161 is provided between the reaction disk 130 and the reagent disk 140, capable of rotating and vertically moving a reagent probe 164. The reagent probe 164 is connected to a reagent syringe 162. The reagent syringe 162 drives the reagent probe 164 to draw and discharge the reagent. After the reagent probe 164 draws the reagent from the reagent container 141, it ascends through the reagent dispensing unit 161 and then moves to the position of the reaction container 131 while describing an arc centered on the rotation axis. Once the reagent probe 164 has reached the position of the reaction container 131, the sample dispensing unit 121 lowers the sample probe 122, dispensing the sample P into the reaction container 131.

[0068] Furthermore, cleaning tanks 163 and 182, a reaction vessel cleaning unit 171, and a stirring unit 181 are arranged around the reaction disk 130. The stirring unit 181 stirs the specimen P and reagent dispensed into the reaction vessel 131. The multiple cleaning tanks 163 and 182 clean the reagent probe 164 and the stirring unit 181, respectively. Therefore, each cleaning tank 163 and 182 is positioned within the operating range of the reagent probe 164 and the stirring unit 181.

[0069] The reaction vessel cleaning unit 171 is connected to a cleaning pump 174. The reaction vessel cleaning unit 171 cleans the reaction vessel 131 using a cleaning solution supplied from the cleaning pump 174. The reaction vessel cleaning unit 171 cleans the reaction vessel 131 after spectroscopic measurement. It is preferable to clean the reaction vessels 131 collectively after spectroscopic measurement of multiple reaction vessels 131 is completed.

[0070] The reaction container 131 in which the sample P and the reagent are stirred is irradiated with light by the light source 172, and the light transmitted through the reaction container 131 is spectrophotometrically measured by the spectrophotometer 173. In this way, the reaction between the sample P and the reagent is analyzed.

[0071] In addition, a detergent cleaning unit 184 for cleaning the sample probe 122 with detergent is arranged on the rotational movement trajectory of the sample probe 122. Usually, the sample container 152 is dispensed into the reaction container 131 multiple times in succession. That is, the sample P is dispensed from the sample container 152 to different multiple reaction containers 131. At the time point when the dispensing from the sample container 152 is completed, the sample probe 122 is cleaned by the detergent cleaning unit 184. At this time, the outside of the sample probe 122 is cleaned with detergent by the detergent cleaning unit 184. The detergent cleaning unit 184 has the form of a bottle containing detergent, and a method of cleaning by inserting the sample probe 122 into the bottle can also be used. Alternatively, a method of supplying detergent from a detergent container (not shown) separately connected to the detergent cleaning unit 184 and discharging the detergent into the sample probe 122 can also be used to clean the sample probe 122.

[0072] Furthermore, the sample dispensing unit 121, the sample syringe 123, the sample probe cleaning unit 110, the reagent dispensing unit 161, the reagent syringe 162, and the stirring unit 181 are connected to the controller 200. Furthermore, the reagent disk 140, the sample transport unit 151, the cleaning pump 174, the spectrophotometer 173, etc. are connected to the controller 200. Figure 1 Although connection lines are not shown, the reaction disk 130, the washing tanks 163 and 182, and the light source 172 are also connected to the controller 200. Specifically, the controller 200 controls the sample dispensing unit 121, the sample syringe 123, the sample probe cleaning unit 110, the reagent dispensing unit 161, the reagent syringe 162, the stirring unit 181, the reaction disk 130, the reagent disk 140, the sample transport unit 151, the washing pump 174, the spectrophotometer 173, the washing tanks 163 and 182, and the light source 172. The control of the sample syringe 123 and the sample probe cleaning unit 110 will be described later.

[0073] <Specimen Probe Cleaning Unit 110>

[0074] Figures 2A to 2C 1 is a diagram showing a specific configuration of the sample probe cleaning unit 110 . Figure 2A A top view showing the specimen probe cleaning unit 110A (110) is shown. Figure 2B A perspective view showing the sample probe cleaning unit 110A is shown. Figure 2C The sample probe cleaning unit 110A is shown. Figure 2A AA section view in.

[0075] Here, it is shown Figures 2A to 2C The sample probe cleaning section 110A shown in the figure discharges the cleaning water W toward the sample probe 122 from below.

[0076] like Figures 2A to 2C As shown in FIG. 1 , the sample probe cleaning unit 110A includes a cleaning water discharge unit 111A, a cleaning water recovery unit 112A, and a cleaning water transfer unit 113A. Figure 2C The dotted arrows in FIG. 4 indicate the movement path of the washing water W. Figure 2A and Figure 2B In the illustrated example, the washing water discharge portion 111A is configured to discharge upward the washing water W. The washing water W discharged upward from the washing water discharge portion 111A via the washing water transfer portion 113A washes the outside of the specimen probe 122 and is then recovered by the washing water recovery portion 112A.

[0077] In addition, the specimen probe 122 is Figure 2AThe sample probe 122 moves in the horizontal direction of the paper (in the direction of the solid arrow). In addition, the left side of the paper is the sample container 152 side, and the right side of the paper is the reaction container 131 side. However, the movement direction of the sample probe 122 is not limited to this direction.

[0078] As mentioned above, in Figures 2A to 2C In the process, the sample probe 122 is moved from the position ( Figure 2A left side of the paper) in the direction of the reaction vessel 131 ( Figure 2A At this time, the sample probe 122 moves in a direction opposite to the discharge direction of the cleaning water W. As a result, the cleaning water W may be scattered. In this case, the controller 200 pre-discharges the cleaning water W (at the right side of the paper) before the sample probe 122 reaches the sample container 152. Figure 7 、 Figure 8 (described later). Furthermore, when the sample probe 122 reaches the sample probe cleaning unit 110, the controller 200 stops the sample probe 122. After the discharge of the washing water W stops and all the washing water W is recovered by the washing water recovery unit 112A, the movement of the sample probe 122 resumes. This can reduce the scattering of the washing water W.

[0079] In addition, the moving direction of the specimen probe 122 can also be Figure 2A as well as Figure 2B The sample probe cleaning section 110A is set in the opposite manner to the example. In this case, the discharge direction of the cleaning water W is the same as the moving direction of the sample probe 122. That is, the discharge direction of the cleaning water W is not opposite to the moving direction of the sample probe 122. Therefore, when the sample probe 122 moves from the position of the sample container 152 to the reaction container 131 side, it can be operated without stopping temporarily (in Figure 9 、 Figure 10 In this case, the scattering can be suppressed by raising the wall 114A of the sample probe cleaning unit 110. Figure 2C The reference numeral D1 will be described later.

[0080] Figure 3A to Figure 3C 1 is a diagram showing a specific configuration of the sample probe cleaning unit 110 . Figure 3A A top view showing the specimen probe cleaning unit 110B (110) is shown. Figure 3B A perspective view showing the sample probe cleaning unit 110B is shown. Figure 3C Indicates the sample probe cleaning unit 110B Figure 3A BB cross-section view in.

[0081] Here, it is shown Figure 3A to Figure 3CThe specimen probe cleaning section 110B shown in FIG. 1 discharges cleaning water W from above toward the specimen probe 122 (see FIG. 110B ). Figure 5E ) examples.

[0082] like Figure 3A to Figure 3C As shown in FIG. 1 , the sample probe cleaning unit 110B includes a cleaning water discharge unit 111B, a cleaning water recovery unit 112B, and a cleaning water transfer unit 113B. Figure 3C The dotted arrows in FIG. 4 indicate the movement path of the washing water W. Figure 3B and Figure 3C As shown, the washing water discharge portion 111B is configured to discharge the washing water W downward. The washing water W discharged downward from the washing water discharge portion 111B via the washing water transfer portion 113B washes the outside of the specimen probe 122 and is then recovered by the washing water recovery portion 112B.

[0083] In addition, if Figure 3A As shown, the specimen probe 122 moves in the longitudinal direction of the paper ( Figure 3A ). In addition, the lower side of the paper is shown as the sample container 152 side, and the upper side of the paper is shown as the reaction container 131 side. However, the moving direction of the sample probe 122 is not limited to this direction.

[0084] Here, in Figure 3A to Figure 3C In the case of the sample probe cleaning unit 110B shown in FIG. 1 , it is not necessary to stop during the rotational movement from the suction position of the sample P to the reaction container 131 (in Figure 9 、 Figure 10 That is, the outside of the sample probe 122 can be cleaned by passing the sample probe 122 through the sample probe cleaning unit 110 while the cleaning water W is being discharged. The thickness of the cleaning water W that the sample probe 122 passes through is different ( Figure 2C Reference numeral D1 Figure 3C denoted by reference numeral D2). That is, Figure 3A to Figure 3C The sample probe cleaning unit 110B shown in FIG. Figures 2A to 2C Compared to the specimen probe cleaning section 110A shown, the thickness of the washing water W that the specimen probe 122 traverses is thinner. Therefore, in the structure of the specimen probe cleaning section 110B, the amount of washing water W that splashes is minimal. Consequently, the wall 114B surrounding the specimen probe cleaning section 110B can effectively suppress the scattering of washing water W.

[0085] Of course, as in Figures 2A to 2C As described in the sample probe washing section 110A, there is no problem even if the sample probe 122 temporarily stops in the sample probe washing section 110B and then moves.

[0086] <Issues of previous methods>

[0087] Figures 4A to 4F This is a diagram showing the problems of the methods used so far.

[0088] If the sample container 152 into which the collected blood has been dispensed is centrifuged, Figure 4A As shown, plasma and serum P1 are separated from blood cells P2. A separating agent B for separating plasma and serum P1 from blood cells P2 exists between the plasma and serum P1 and the blood cells P2. Figure 4B As shown, a layer containing a large amount of unstable components U, which should be present below the separating agent B, is located above the plasma and serum P1. Although this depends on the centrifugal separation conditions, most of the unstable components U are contained within a depth of 2 mm from the surface. The following description uses plasma and serum P1 as the specimen P.

[0089] In order to prevent empty suction, the insertion depth of the specimen probe 122 is generally about 3 to 4 mm when sucking the specimen P. As mentioned above, the unstable component U is mostly present within the range of 2 mm on the surface. Therefore, if the insertion depth of the specimen probe 122 is set to 3 to 4 mm, then Figure 4C As shown, the sample P (plasma and serum P1) is aspirated from the lower layer of the range containing the unstable component U. Thus, the sample probe 122 does not aspirate the unstable component U. Although the aspirated sample P exists in the sample probe 122, it is not shown here.

[0090] However, when the specimen probe 122 is pulled out from the specimen P after the suction of the specimen P is completed, Figure 4D As shown in FIG, the specimen P is attached to the outside of the specimen probe 122. Figure 4D As shown in FIG, the sample P attached to the outside of the sample probe 122 contains an unstable component U. Therefore, there is a possibility that the unstable component U may be attached to the outside of the sample probe 122.

[0091] Furthermore, when the specimen P is discharged into the reaction container 131, Figure 4E As shown, the specimen P is discharged while the specimen probe 122 is in contact with the bottom surface of the reaction container 131 ( Figure 4E ). Generally, the tip of the sample probe 122 is generally cut obliquely. Therefore, even if the sample probe 122 comes into contact with the reaction container 131, it will not be clogged, and the sample P can be discharged stably.

[0092] In addition, in general, the amount of the specimen P attracted by the specimen probe 122 is extremely small. Figure 4E As shown in FIG, the discharged sample P is in a dome-shaped shape around the sample probe 122 due to surface tension and does not drip. Figure 4E As shown, the dome-shaped specimen P contains an unstable component U adhering to the outside of the specimen probe 122 .

[0093] If from Figure 4E From the state shown, the specimen probe 122 is pulled out and raised ( Figure 4F ), then Figure 4F As shown, the unstable component U mixed in the sample P may remain in the reaction container 131 .

[0094] from Figure 4E From the state shown, the reagent is dispensed into the reaction vessel 131, and the reaction solution is stirred by the stirring unit 181 before measurement. However, the reaction solution may contain an unstable component U, and thus a stable measurement result may not be obtained.

[0095] In addition, consider Figure 4E As shown, the specimen P is discharged while the specimen probe 122 is floating from the bottom of the reaction vessel 131, rather than being in contact with the bottom of the reaction vessel 131. However, as described above, the amount of specimen P aspirated by the specimen probe 122 is extremely small. Therefore, if the specimen P is discharged while the specimen probe 122 is floating from the bottom of the reaction vessel 131, the specimen P will accumulate in a clumping state around the discharge port of the specimen probe 122 due to surface tension. Consequently, the specimen P cannot be dispensed into the reaction vessel 131. Furthermore, even if the specimen probe 122 floats from the bottom of the reaction vessel 131, discharge is possible as long as the tip of the specimen probe 122 is very close to the reaction vessel 131.

[0096] <Method of Midway Cleaning E1 in This Embodiment>

[0097] Figures 5A to 5H This is a diagram illustrating a method for midway cleaning E1 in this embodiment. Figures 5A to 5H In, with Figures 4A to 4F The same configurations are denoted by the same reference numerals and their descriptions are omitted.

[0098] Figures 5A to 5D and Figures 4A to 4D The same, therefore, the description is omitted.

[0099] exist Figure 5D In the embodiment, after the specimen P is sucked and before the specimen P is discharged into the reaction container 131, Figure 5E As shown in FIG. 1 , the sample probe cleaning unit 110 cleans the outside of the sample probe 122 using cleaning water W. As a result, as shown in FIG. Figure 5F As shown in FIG, the unstable component U is washed away together with the specimen P attached to the outside of the specimen probe 122. Figure 5G As shown, the sample P is discharged into the reaction container 131 while the sample probe 122 is in contact with the bottom surface of the reaction container 131 ( Figure 5G ). Figure 5E As shown, the unstable components U attached to the outside of the sample probe 122 are washed away by the sample probe cleaning unit 110 before being discharged into the reaction container 131. Figure 5H ), then Figure 5H As shown, the unstable component U is not mixed in the sample P discharged into the reaction container 131 , and therefore a stable measurement result can be obtained.

[0100] <Timing Diagram: Second Cleaning>

[0101] Figure 6 It is a diagram showing a timing chart during the second cleaning. Figure 6 The timing chart shown shows the turning on and off of the control signal sent from the controller 200 .

[0102] exist Figure 6 The timing charts shown, from the top, illustrate the rotational movement of the sample probe 122 by the sample dispensing unit 121 (chart C1), the vertical movement of the sample probe 122 (chart C2), the driving state of the sample syringe 123 (chart C3), and the on and off of the discharge of the washing water W by the sample probe washing unit 110 (chart C4). The same reference numerals are used in the following timing charts for Graphs C1 to C4.

[0103] First, after the last dispensing of the sample P is completed, the sample dispensing unit 121 starts rotating (time t1 ). As a result, the sample probe 122 starts rotating from the sample probe cleaning unit 110 to the position of the sample container 152 (graph C1 ).

[0104] While the sample probe 122 is rotating from the sample probe cleaning unit 110 toward the sample container 152, the sample dispensing unit 121 aspirates air from the sample probe 122 (time t2: Figure C3). The sample probe 122 is filled with system water, which is different from the washing water W. However, the aspiration of air creates air between the system water and the sample P. This prevents mixing of the system water and the sample P. Furthermore, the aspiration of air can be omitted after the initial aspiration.

[0105] The suction of air ends before the sample probe 122 reaches the position of the sample container 152 (time t3).

[0106] When the sample probe 122 reaches the position of the sample container 152 , the sample dispensing unit 121 is instructed to lower the sample probe 122 (time t4 ).

[0107] When the sample probe 122 descends a predetermined amount, the sample P in the sample container 152 is aspirated into the sample probe 122 by the sample syringe 123 (time t5). When aspiration of the sample P is completed at time t6, the sample P is discharged by backflushing (time t6-t7: graph C3).

[0108] When the backflushing is completed, the sample probe 122 rises and starts rotational movement from the position of the sample container 152 to the position of the reaction container 131 (time t8 ).

[0109] At time t9 , when the sample probe 122 reaches the position of the reaction container 131 , the rotational movement stops (graph C1 ), and the sample probe 122 starts to descend (graph C2 ).

[0110] When the specimen probe 122 completes its descent, the specimen syringe 123 is driven (graph C3 ) to discharge the specimen P into the reaction container 131 (time t10 to t11 ).

[0111] When the discharge of the specimen P is completed (time t11 ), the specimen probe 122 rises (graph C2 ) and starts rotational movement from the position of the reaction container 131 to the position of the specimen probe cleaning unit 110 ( t12 : graph C1 ).

[0112] Before the sample probe 122 reaches the sample probe washing section 110 , the discharge of the washing water W by the sample probe washing section 110 is turned on (time t13 : graph C4 ).

[0113] When the sample probe 122 reaches the sample probe cleaning unit 110, its rotation stops (graph C1). As the rotation stops, the sample P remaining in the sample probe 122 is discharged by the sample syringe 123 (time t14: graph C4). At time t14, the cleaning water W has been discharged, and the sample P remaining outside and inside the sample probe 122 has been rinsed. In other words, post-dispensing cleaning E2 is performed.

[0114] When the cleaning of the sample probe 122 is completed, the sample syringe 123 rises and returns to a predetermined position (time t15: graph C3). Thereafter, the discharge of the cleaning water W in the sample probe cleaning unit 110 is stopped (time t16: graph C4).

[0115] As described above, in the second cleaning, after the aspiration of the specimen P, the operation of cleaning the outside of the specimen probe 122 is not performed until the discharge of the specimen P into the reaction container 131 is completed.

[0116] <Time Chart: 1st Cleaning>

[0117] Figure 7FIG. 1 is a diagram showing a timing chart of the first cleaning in the first embodiment. Figure 7 The timing diagram shown shows the on and off of the control signal sent from the controller 200. Figure 7 In, with Figure 6 The same structures are marked with the same reference numerals. Figure 6 The different parts are explained.

[0118] In addition, Figure 7 The following timing diagram ( Figure 7 、 Figure 9 、 Figure 11 、 Figure 13 、 Figure 14A 、 Figure 14B 、 Figure 15A 、 Figure 15B ) in order to avoid complexity, the illustration of moments other than the necessary moments is omitted. Figure 7 、 Figure 9 、 Figure 11 、 Figure 13 、 Figure 14A 、 Figure 14B 、 Figure 15A 、 Figure 15B In the figure, the time and Figure 6 same.

[0119] Figure 7 The actions shown are Figure 6 The difference in the illustrated operation is that after the specimen P is sucked from the specimen container 152 , an intermediate cleaning E1 is performed before the specimen P is discharged into the reaction container 131 .

[0120] That is, the suction and backflushing of the specimen P are completed, and the rotation movement from the position of the specimen container 152 to the position of the reaction container 131 is started (graph C1). Figure 6 The same action is performed at time t8 in .

[0121] Furthermore, before the sample probe 122 reaches the position of the sample probe washing section 110 , the discharge of the washing water W by the sample probe washing section 110 is turned on (time t21 : graph C4 ).

[0122] Thereafter, when the sample probe 122 reaches the sample probe cleaning unit 110 , the rotational movement of the sample dispensing unit 121 stops (time t22 : graph C1 ), thereby cleaning the outside of the sample probe 122 .

[0123] When the cleaning is completed, first, the discharge of the cleaning water W is turned off (time t23: graph C4), and then the rotation movement of the sample dispensing unit 121 is restarted (time t24: graph C1). Figure 6The same process is performed after time t9 in FIG.

[0124] (Rotation Speed ​​of Sample Probe 122)

[0125] Figure 8 Yes Figure 7 The graph of the time change of the rotation speed of the specimen probe 122 between time t8 and t9 is shown. Figure 8 In the figure, reference symbol W1 is the time when the washing water W is turned on.

[0126] Each time and Figure 7 The time shown is the same, so it will not be explained here, but Figure 8 The rotation action is shown in FIG, so the rotation speed is inclined from the start of rotation until the rotation speed reaches the specified value. Figure 8 In the example, the draining of the washing water W is stopped substantially simultaneously with the stopping of the rotational movement of the specimen probe 122. However, the present invention is not limited thereto, and the draining of the washing water W may be performed at a predetermined time after the stopping of the rotational movement of the specimen probe 122.

[0127] According to the first embodiment, Figure 7 as well as Figure 8 As shown in FIG. 1 , after the sample P is sucked and moved to the reaction container 131, the sample probe 122 is cleaned by the sample probe cleaning unit 110. Thus, before the sample P is discharged into the reaction container 131, the outer side of the sample probe 122 can be cleaned in the sample probe cleaning unit 110. Figure 5H As shown, it is possible to prevent the unstable component U from being mixed in the specimen P accommodated in the reaction container 131 .

[0128] Furthermore, during the intermediate cleaning E1 , the rotational movement of the sample probe 122 is stopped, thereby improving the cleaning effect by the intermediate cleaning E1 .

[0129] The second cleaning and the first cleaning are switched as appropriate. The switching between the second cleaning and the first cleaning will be described later in the sixth embodiment.

[0130] As mentioned above, in Figure 2A and Figure 2B In the case of the structure shown, that is, the structure in which the washing water W is discharged from the bottom to the top, Figure 7 and Figure 8The operation shown in FIG. Specifically, during the intermediate cleaning process E1, the drain of the cleaning water W is turned on before the sample probe 122 reaches the sample probe cleaning unit 110. Furthermore, when the sample probe 122 reaches the sample probe cleaning unit 110, the rotation of the sample probe 122 is stopped. Furthermore, when the cleaning process is completed, the drain of the cleaning water W is turned off, and the rotation of the sample probe 122 is resumed. This operation can reduce the scattering of the cleaning water W.

[0131] In addition, Figure 7 and Figure 8 In the embodiment, before the sample probe 122 reaches the position of the sample probe cleaning unit 110, the discharge of the washing water W is turned on. On this basis, when the sample probe 122 reaches the position of the sample probe cleaning unit 110, the rotation movement of the sample probe 122 stops. However, this is not limited to this. Alternatively, as the sample probe 122 reaches the position of the sample probe cleaning unit 110, the discharge of the washing water W is turned on ( Figure 7 and Figure 8 Alternatively, after the sample probe 122 reaches the position of the sample probe cleaning unit 110, the discharge of the cleaning water W may be turned on (at Figure 7 as well as Figure 8 (time t21>time t22).

[0132] In addition, Figure 7 and Figure 8 In the embodiment, the rotation movement of the sample probe 122 is restarted after the discharge of the washing water W is stopped, but the present invention is not limited thereto. For example, the timing of stopping the discharge of the washing water W and the timing of restarting the rotation movement of the sample probe 122 may coincide with each other ( Figure 7 as well as Figure 8 Alternatively, the discharge of the washing water W may be turned off (at Figure 7 as well as Figure 8 (time t23>time t24).

[0133] In addition, Figure 7 and Figure 8 In the illustrated operation, the intermediate cleaning E1 is an additional operation. Therefore, it is preferable that each operation be different from the second cleaning. For example, it is preferable to increase the rotational movement speed, ascending speed, and descending speed of the specimen probe 122. In this way, even if the intermediate cleaning E1 is performed, the overall operation time can be kept the same as the second cleaning.

[0134] During the intermediate wash E1, the sample P adhering to the outside of the sample probe 122 is flushed out along with the unstable components U. The amount of sample P discharged from the sample probe 122 into the reaction vessel 131 generally also includes the sample P adhering to the outside of the sample probe 122. Therefore, if the intermediate wash E1 is performed, the amount of sample P ultimately discharged into the reaction vessel 131 is reduced compared to the second wash. When the sample P is discharged into the reaction vessel 131, the amount of sample P adhering to the outside of the sample probe 122 is generally less than 0.1 μL. However, in recent years, the amount of sample P has tended to be minute, and the presence or absence of sample P adhering to the sample probe 122 has a significant impact. For example, if the amount discharged into the reaction vessel 131 is 1 μL, the intermediate wash E1 flushes out nearly 10% of the amount discharged into the reaction vessel 131.

[0135] Therefore, when the first wash in this embodiment is used, it is preferable to set a calibration for the first wash when aspirating and discharging the specimen P into the reaction vessel 131. That is, when pre-aspirating the specimen P, it is preferable to aspirate a large amount of the specimen P washed in the intermediate wash E1. Furthermore, when discharging the specimen P, it is preferable to discharge the specimen P at a discharge volume that has been adjusted. In other words, it is preferable to set the discharge volume to the amount obtained by adding the large amount aspirated during aspiration of the specimen P. This ensures the accuracy of dispensing the specimen P.

[0136] [Second embodiment]

[0137] Next, refer to Figure 9 as well as Figure 10 , the second embodiment of the present invention will be described. In addition, even in the subsequent embodiments, the switching process between the first cleaning and the second cleaning is performed in the same manner as in the first embodiment, but the switching process between the first cleaning and the second cleaning will be described later through the sixth embodiment (the same applies to the third to fifth embodiments).

[0138] <Timing Diagram: 1st Cleaning>

[0139] Figure 9 It is a diagram showing a timing chart of the first cleaning in the second embodiment. Figure 9 The timing diagram shown shows the on and off of the control signal sent from the controller 200. Figure 9 In, with Figure 7 The same structures are marked with the same reference numerals. Figure 7 The different parts are explained.

[0140] and, Figure 10 : is a graph showing the time change of the rotation speed of the sample probe 122 in the first cleaning of the second embodiment. Figure 10 In, with Figure 8The same structures are marked with the same reference numerals. Figure 8 The different parts are explained.

[0141] exist Figure 7 and Figure 8 In the first cleaning shown in FIG. 1 , when the sample probe 122 reaches the position of the sample probe cleaning unit 110 in the intermediate cleaning E1, the rotational movement of the sample probe 122 stops. Figure 9 and Figure 10 In the first cleaning shown, even if the sample probe 122 reaches the position of the sample probe cleaning section 110 during the intermediate cleaning E1 , the rotational movement of the sample probe 122 does not stop.

[0142] In addition, the sample probe cleaning unit 110 may have a structure that is difficult to scatter (for example, Figure 3A as well as Figure 3B In this case, the rotation movement from the position of the sample container 152 to the position of the reaction container 131 may not be stopped. In this case, as shown in FIG. Figure 9 and Figure 10 As shown, the specimen probe 122 can be passed through while the washing water W is being discharged. Thus, in the second embodiment, the intermediate cleaning E1 is performed without stopping the rotation of the specimen probe 122. Thus, as in the first embodiment, to ensure time for the intermediate cleaning E1, even without increasing the rotational speed, ascending speed, and descending speed of the specimen probe 122, the entire process can be completed in a time comparable to that of the second cleaning.

[0143] The user may determine whether to stop the rotational movement of the sample probe 122 during the intermediate cleaning E1 as in the first embodiment or not to stop the rotational movement of the sample probe 122 as in the second embodiment, depending on the configuration of the sample probe cleaning unit 110 .

[0144] [Third embodiment]

[0145] Next, refer to Figure 11 as well as Figure 12 , a third embodiment of the present invention is described.

[0146] <Timing Diagram: 1st Cleaning>

[0147] Figure 11 FIG. 1 is a diagram showing a timing chart of the first cleaning in the third embodiment. Figure 11 The timing diagram shown shows the on and off of the control signal sent from the controller 200. Figure 11 In, with Figure 9 The same structures are marked with the same reference numerals. Figure 9 The different parts are explained.

[0148] and, Figure 12 : is a graph showing the time change of the rotation speed of the sample probe 122 in the first cleaning of the third embodiment. Figure 12 In, with Figure 8 The same structures are marked with the same reference numerals. Figure 8 The different parts are explained.

[0149] exist Figure 11 and Figure 12 In the action shown, Figure 9 and Figure 10 Likewise, the rotational movement of the sample probe 122 is not stopped during the intermediate cleaning E1. Figure 11 and Figure 12 In the operation shown, the rotational movement speed of the sample probe 122 is reduced before the sample probe 122 reaches the sample probe cleaning unit 110 (time t31: Figure 11 Figure C1). That is, if Figure 12 As shown, at time t31, the rotational movement speed is reduced from the rotational movement speed v1 to the rotational movement speed v2 (v2<v1).

[0150] Then, after the rotational movement speed of the sample probe 122 is sufficiently reduced, the washing water W is discharged (time t21 ).

[0151] According to the third embodiment, the cleaning time can be extended by reducing the rotational movement speed of the sample probe 122 during the intermediate cleaning E1. Therefore, the outside of the sample probe 122 can be cleaned further than in the first and second embodiments.

[0152] Furthermore, by reducing the rotational movement speed of the upper specimen probe 122 during the intermediate cleaning E1 , scattering of the cleaning water W can be reduced.

[0153] In addition, if Figure 11 、 Figure 12 As shown, if the rotational movement speed of the sample probe 122 is reduced during the intermediate cleaning E1, the time required for the sample probe 122 to move from the position of the sample container 152 to the position of the reaction container 131 increases. Therefore, it is preferable to increase the rotational movement speed, ascending speed, descending speed, etc. of the sample probe 122 during the cleaning process other than the intermediate cleaning E1. This can reduce the time difference with the second cleaning process and prevent the overall processing time from being prolonged.

[0154] In addition, Figure 11 and Figure 12In the illustrated operation, the rotational movement speed is temporarily reduced while being moved to the position of the reaction container 131 . However, the rotational movement speed may be restored after the discharge of the washing water W is stopped.

[0155] [Fourth embodiment]

[0156] <Timing Diagram: 1st Cleaning>

[0157] Figure 13 FIG. 1 is a diagram showing a timing chart of the first cleaning in the fourth embodiment. Figure 13 The timing diagram shown shows the on and off of the control signal sent from the controller 200. Figure 9 In, with Figure 6 as well as Figure 7 The same structures are marked with the same reference numerals. Figure 7 The different parts are explained.

[0158] exist Figure 13 In the operation shown, the time from the end of aspiration of the specimen P to the end of recoil (time t6a to t7a) is advanced (graph C3). Figure 13 The dotted line indicates Figure 7 Furthermore, as the time from the end of suction of the specimen P to the end of recoil is advanced, the rotational movement start time of the specimen probe 122 is also advanced (time t7a: graph C1).

[0159] As the rotation start time of the sample probe 122 is advanced, the time when the sample probe 122 reaches the position of the sample probe cleaning unit 110 is also advanced. Therefore, the time when the discharge of the cleaning water W is turned on and the time when the rotation of the sample probe 122 is stopped are also advanced (time t21a, t22a: Graphs C1 and C4).

[0160] Furthermore, when the rotation start time is advanced to the dashed line in the graph C3, the timing of turning on the discharge of the washing water W is also advanced as shown by the dashed line in the graph C4. Furthermore, the timing of turning off the discharge of the washing water W (time t23) and the timing of restarting the rotation of the specimen probe 122 (time t24) are similar to the timing of turning off the discharge of the washing water W (time t23). Figure 7 The same situation is shown.

[0161] That is, in Figure 13 In the illustrated operation, the aspiration time of the specimen P is shortened, and accordingly, the time for the intermediate wash E1 is prolonged. Specifically, the time during which the cleaning water W is discharged from the specimen probe cleaning unit 110 is extended, and the time during which the rotation of the specimen probe 122 is stopped is extended. Consequently, the cleaning time for the intermediate wash E1 is prolonged. In short, the shorter the aspiration time of the specimen P, the longer the intermediate wash E1.

[0162] In the fourth embodiment, the rotation of the specimen probe 122 is stopped, but the rotation of the specimen probe 122 may be stopped. Figure 11 、 Figure 12 Thus, the rotational movement speed is made slower than that before the sample probe 122 reaches the position of the sample probe cleaning unit 110 .

[0163] The inspection items that are likely to cause obstruction to the inspection results due to the unstable component U can be known in advance. Therefore, among the inspection items that are likely to cause obstruction to the inspection results due to the unstable component U, Figure 13 As shown, the time required to aspirate the specimen P for analysis is shortened. Specifically, the aspiration speed of the specimen syringe 123 is increased to shorten the aspiration time of the specimen P, and the specimen probe 122 is started to ascend and rotate after the aspiration of the specimen P is completed. Alternatively, in the case of a small amount of specimen P required for an inspection item that is likely to affect the inspection results due to unstable components U, the minimum aspiration time required for aspiration of the specimen P is ensured.

[0164] For example, a typical aspiration operation of a specimen P requires 500 ms to complete aspiration of 1 to 25 μL. In contrast, for an examination item where unstable components U can easily affect test results, the amount of specimen P required is 2 μL, and the required aspiration time is 200 ms. In this case, the rotation of the specimen probe 122 can be started 300 ms earlier, and the intermediate cleaning E1 can also be started 300 ms earlier.

[0165] Thus, in the first cleaning of the fourth embodiment, the rotational movement of the sample probe 122 begins earlier than in the first cleaning of the first embodiment. Consequently, the start time of the intermediate cleaning E1 can be advanced, thereby extending the duration of the intermediate cleaning E1. Therefore, according to the fourth embodiment, the outer side of the sample probe 122 can be cleaned further than in the first embodiment.

[0166] [Fifth embodiment]

[0167] In the fourth embodiment, the cleaning of the outside of the sample probe 122 is described, but it is also considered that the cleaning of the outside of the sample probe 122 is insufficient. Figure 6 、 Figure 7 、 Figure 9 、 Figure 11 、 Figure 13 The timing diagram assumes that all the dispensing operations are performed in one cycle. In contrast, the purpose of the fifth embodiment is to perform the first cleaning in multiple cycles, thereby reducing the intermediate cleaning E11 ( Figure 14B) ensures a long time. This allows for sufficient cleaning of the sample probe 122, resulting in more stable dispensing results. In the fifth embodiment, the controller 200 controls the operation of the automated analysis system 1 by setting a predetermined time as one cycle. For example, one cycle is 3.6 seconds.

[0168] use Figure 14A as well as Figure 14B The fifth embodiment of the present invention will be described in detail.

[0169] <Timing Diagram: 1st Cleaning>

[0170] Figure 14A Is with Figure 7 In the same timing diagram, a dashed line (MM) indicating a cycle boundary is inserted. Figure 14A Shows the implementation of 1 cycle Figure 7 The timing diagram is divided into 2 cycles at the MM position.

[0171] Figure 14B It specifically shows that Figure 14A The timing diagram is divided into two cycles of action in MM. Figure 14B In FIG, the boundaries of the cycles are shown by MM lines (single-dot chain lines). The execution time of each cycle is the same.

[0172] Figure 14B The timing diagram shown shows the on and off of the control signal sent from the controller 200. Figure 14B In, with Figure 7 The same structures are marked with the same reference numerals. Figure 7 Different parts are explained. Figure 14B In the diagram, the graph C1 is divided into the first half (reference numeral C11) and the second half (reference numeral C12). The same applies to graphs C2 to C3 (first half: reference numerals C21, C31, C41, second half: reference numerals C22, C32, C42). Figure 14B In the diagram, two MM lines are shown. The MM line on the left side of the paper indicates the end of the first half and the beginning of the second half. The MM line on the right side of the paper indicates the end of the second half and the beginning of the first half. The period from one MM line to the next MM line is the same length.

[0173] Figure 14B The actions shown are Figure 7The difference in the illustrated operation is that, in the first cycle, after the specimen P is aspirated from the specimen container 152 (time t7), an intermediate wash E11 is performed before the specimen probe 122 is moved to the reaction container 131 (before reaching time t91). Furthermore, while the movement of the specimen probe 122 is stopped during the intermediate wash E11, the intermediate wash E11 can also be performed while the specimen probe 122 is moving. Furthermore, in this embodiment, in the second cycle, the specimen probe 122 is rotated toward the reaction container 131 (times t241 to t91), and dispensing is performed into the reaction container 131 (times t10 to t11). Following this dispensing, a post-dispensing wash E2 is performed.

[0174] That is, the suction and backflushing of the specimen P are completed (time t7), and the rotation movement from the position of the specimen container 152 to the position of the specimen probe cleaning unit 110 is started (the first half of the diagram C1: reference symbol C11). Figure 7 The operations performed at time t7 to t8 in FIG. 1 are the same.

[0175] After the sample probe 122 reaches the position of the sample probe cleaning unit 110, the discharge of the cleaning water W by the sample probe cleaning unit 110 is turned on (time t211: first half of Figure C4: reference symbol C41). This is the operation of the intermediate cleaning E11. Here, the cleaning time is preferably the same as the time for the post-dispensing cleaning E2 (the time for the intermediate cleaning E11 and the time for the post-dispensing cleaning E2 are both T). This is because during the post-dispensing cleaning E2 performed when the sample P is switched, the outside of the sample probe 122 can be fully cleaned, and even if unstable components U are attached, they can be fully removed.

[0176] In addition, in the fifth embodiment, although Figure 1In the diagram of the automatic analysis system 1, the specimen probe cleaning section 110 is connected to a cleaning water pump (not shown), which is used to discharge cleaning water W. Each cleaning tank 163, 182 discharges cleaning water W to clean the reagent probe 164 and the stirring section 181. For example, the specimen probe cleaning section 110 and the cleaning tanks 163, 182 are discharged by a single cleaning water pump, and the on / off of the discharge of cleaning water is controlled by a solenoid valve (not shown). The cleaning start time of the specimen probe cleaning section 110 and the cleaning tanks 163, 182 used for cleaning is respectively carried out at a time determined within one cycle. When observed within one cycle, each solenoid valve is opened and closed at the same timing. Therefore, if the solenoid valve is opened and closed when using cleaning water W, the water pressure of the cleaning water pump changes as determined. If the solenoid valve is opened, the water pressure in the cleaning water pump decreases, and if the solenoid valve is closed, the water pressure in the cleaning water pump increases. Taking into account the decrease and increase in water pressure, the driving of the washing water pump is controlled so that the washing water W is discharged at a predetermined water pressure. By implementing the predetermined control, the washing water W can be discharged at a stable water pressure without causing fluctuations in water pressure within one cycle.

[0177] When performing the mid-way wash E11 of the specimen probe 110 in the first half of the first wash cycle, if the opening and closing timing of the solenoid valve of the specimen probe 110 is set to the same timing (timing) as the post-dispensing wash E2 within the same cycle, the water pressure fluctuates similarly in the first and second washes. Therefore, if the wash water pump is controlled similarly in the first and second washes, the wash water W can be discharged at a predetermined water pressure. However, if the start time of the mid-way wash E11 within the same cycle differs from that of the post-dispensing wash E2, the fluctuation balance of the wash water pump water pressure is lost, causing a deviation in the water pressure when performing the post-dispensing wash E2 between the first and second washes.

[0178] That is, in Figure 14B The water pressure of the wash water pump during the post-dispensing wash E2 differs between when the mid-way wash E11 is performed and the wash water W is temporarily drained (the first wash) and when the mid-way wash E11 is not performed and the wash water W is not drained (the second wash). This causes a difference in the water pressure during the post-dispensing wash E2 between the first and second washes. However, as described above, the specimen probe cleaning unit 110 and the wash tanks 163 and 182 may be drained by a single wash water pump. Therefore, the difference in water pressure during the post-dispensing wash E2 is not simply due to the presence or absence of the mid-way wash E11 (E1).

[0179] In the fifth embodiment, the time (timing) of the midway cleaning E11 and the post-dispensing cleaning E2 is made to operate at the same time (timing) in each cycle. That is, the time Δt between the boundary (single-dot dash line) of each cycle and the end time of the midway cleaning E11 and the post-dispensing cleaning E2 is respectively the same, and the time T for each of the midway cleaning E11 and the post-dispensing cleaning E2 is the same. In other words, in each cycle, the start time and the end time of the midway cleaning E11 and the post-dispensing cleaning E2 are the same. Thus, the cleaning of the midway cleaning E11 can be shared with the cleaning in the cleaning tanks 163 and 182 in the same manner as the post-dispensing cleaning E2. Thus, by pressurizing the cleaning water pump in the automatic analyzer 100, the fluctuation range of the pressure balance of the cleaning water W used for cleaning can be suppressed to a specified fluctuation range even in other mechanisms. Therefore, in the first cleaning and the second cleaning, the cleaning efficiency of the post-dispensing cleaning E2 will not deviate.

[0180] Furthermore, even if the cleaning time for the sample probe 122 is set to "interim cleaning E11 < post-dispensing cleaning E2," no effect will be achieved. Even if the sample P adhering to the side of the sample probe 122 is not completely removed, it is sufficient to remove the unstable components U through cleaning. Therefore, the cleaning time for the intermediate cleaning E11 can be determined while considering the cleaning efficiency of the post-dispensing cleaning E2. This also contributes to water conservation.

[0181] Thereafter, in the next cycle (second half), the reaction container 131 is dispensed, and the inside and outside of the sample probe 122 are cleaned (post-dispensing cleaning E2 ), and the dispensing cycle is completed.

[0182] In the case of large-volume dispensing (e.g., 20 μL or more) of the specimen P, two cycles may be used for dispensing. This is because the aspirated amount of specimen P is also large, so aspiration and washing time are long and time-consuming.

[0183] In order to avoid the influence of the unstable component U even when dispensing a large amount, the number of cycles can be set to 2 to 3 cycles. Figure 15A and Figure 15B Explain this.

[0184] Figure 15A This is a timing chart showing the case where the process is performed in two cycles. Figure 15A The dividing line of the loop in is the single-dot dash line M1-M1. In addition to the single-dot dash line M1-M1, Figure 15B It is also shown that Figure 15A The single dotted line M2-M2 further divides the timing diagram of the cycle. In addition, Figure 15A and Figure 15B Indicates a large amount of dispensing action (for example, a dispensing volume of 20 μL). Figure 15A as well as Figure 15B In the diagram, the timing of each process is omitted. Figure 15A 、 Figure 15B In, with Figure 7 The same structures are marked with the same reference numerals and their descriptions are omitted. Figure 15B In the figure, the dot-dashed line indicates the boundary of the loop.

[0185] exist Figure 15A , the first half is denoted by reference numerals C11A to C41A, and the second half is denoted by reference numerals C12A to C42A.

[0186] exist Figure 15A In the second half of the graph C4 (reference symbol C42A), two post-dispensing cleanings E2 (post-dispensing cleanings E21 and E22) are performed.

[0187] also, Figure 15A The case where the first cleaning is performed is shown, and therefore, the midway cleaning E1 is performed. However, in the case of the second cleaning, the midway cleaning E1 is not performed.

[0188] exist Figure 15B The timing diagram for the dispensing operation is divided into three cycles. The first cycle is represented by reference numerals C11B to C41B, the second cycle is represented by reference numerals C12B to C42B, and the third cycle is represented by reference numerals C13B to C43B. The boundaries between the cycles are indicated by single-dotted dashed lines. The execution time of each cycle is the same.

[0189] exist Figure 15B In the example shown, the intermediate cleaning E11 is performed in the first cycle (see reference numeral C41B). Furthermore, the post-dispensing cleaning E23 (E2) is performed in the second cycle (see reference numeral C42B). Furthermore, the post-dispensing cleaning E24 (E2) is performed in the third cycle (see reference numeral C43B).

[0190] When a large amount of dispensing is performed, generally after the dispensing is completed, a large amount of sample P is attached to the inside and outside of the sample probe 122. Figure 15A and Figure 15B As shown, by performing the post-dispensing cleaning E2 for a long time multiple times or once, the cleaning effect of the sample probe 122 can be improved even when a large amount of dispensing is performed.

[0191] In addition, Figure 15BIn the example shown, the intermediate wash E11 and post-dispensing washes E23 and E24 are performed at the same timing in each cycle. Specifically, the time Δt between the boundary of each cycle (the dashed line) and the end time of the intermediate wash E11, post-dispensing wash E23, and E24 is the same, and the time T for each of the intermediate wash E11, post-dispensing wash E23, and E24 is the same. In other words, the start and end times of the intermediate wash E11, post-dispensing wash E23, and E24 are the same in each cycle. This, as described above, can reduce variations in the water pressure of the wash water W.

[0192] In addition, Figure 15B In the third cycle, for example, post-dispensing wash E2 may be added between post-dispensing wash E23 and post-dispensing wash E24 of the second cycle. Generally, the more post-dispensing wash E2 is performed, the less carryover of the specimen P can be achieved.

[0193] like Figure 15A and Figure 15B As shown, the method of splitting by a large number of injections is the same as Figure 14A The same method is used in . That is, Figure 15A and Figure 15B As shown, in the first cycle, the cycle can be divided at the position of performing the intermediate cleaning E11 after the sample is aspirated by the sample probe 122. In subsequent cycles, the sample can be discharged into the reaction container 131 and the inside and outside of the sample probe 122 can be cleaned (post-dispensing cleaning E2).

[0194] By the way, although Figure 15A as well as Figure 15B Although not shown in the figure, in the post-dispensing cleaning E2, external washing of the sample probe 122 is performed, and internal washing for cleaning the inside of the sample probe 122 is also performed (the same applies to the post-dispensing cleaning E2 in other figures).

[0195] Furthermore, for measurement items affected by unstable components U, calibration and control measurements are preferably performed using the intermediate washes E1 and E11 described in this embodiment. This is because the washes cause the sample adhering to the outside of the sample probe 122 to fall. Therefore, even if the sample volume is corrected for the amount of fall and discharged into the reaction vessel 131, some error may occur. Therefore, it is preferable to use the same operation sequence for dispensing.

[0196] In addition, in this embodiment, the washing pump 174 and the washing water pump (not shown) are provided separately, but they may be provided as a common pump. Even if a common pump is used, the same effect can be obtained.

[0197] [Sixth embodiment: Switching between the first cleaning and the second cleaning]

[0198] <Controller 200>

[0199] Figure 16 This is a functional block diagram of the controller 200 according to this embodiment.

[0200] The controller 200 includes a processing unit 210 , a storage unit 220 , an input unit 201 , an output unit 202 , and a communication unit 203 .

[0201] The storage unit 220 includes action registration data 221 and action sequence list data 222 .

[0202] The action registration data 221 stores inspection items for each pharmaceutical company.

[0203] The operation sequence list data 222 stores the execution sequence of the inspection items.

[0204] The action registration data 221 and the action sequence list data 222 will be described later.

[0205] The processing unit 210 includes a reading unit 211 , a determination unit 212 , and an operation control unit 213 .

[0206] The reading unit 211 reads data (operation data) of the inspection item to be performed next from the operation sequence list data 222 .

[0207] The determination unit 212 determines whether to perform the first cleaning or the second cleaning.

[0208] The operation control unit 213 controls the operations of the sample dispensing unit 121 , the reaction container washing unit 171 , the sample syringe 123 , and the like.

[0209] The input unit 201 is a keyboard, mouse, etc., and the output unit 202 is a display, etc. The communication unit 203 transmits and receives information to and from various units of the automatic analyzer 100 , such as the sample dispensing unit 121 , the reaction vessel washing unit 171 , and the sample syringe 123 .

[0210] Figure 17 It is a diagram showing the hardware configuration of the controller 200 according to this embodiment.

[0211] The controller 200 includes a memory 251 , a CPU (Central Processing Unit) 252 , a storage device 253 , an input device 254 , an output device 255 , and a communication device 256 .

[0212] The storage device 253 is a hard disk (HD) or the like, which is equivalent to Figure 16 The storage unit 220. In addition, the input device 254 is equivalent to Figure 16 The input unit 201 and the output device 255 are equivalent to Figure 16 The output unit 202, the communication device 256 is equivalent to Figure 16 Communications Department 203.

[0213] The program stored in the storage device 253 is loaded into the memory 251. Then, the CPU 252 executes the loaded program to realize Figure 16 210~213 of each part.

[0214] <Flowchart>

[0215] Figure 18 1 and 2. As described above, a plurality of dispensing operations are performed continuously from one sample container 152 to the reaction container 131. Figure 18 The processing assumes a dispensing process for one sample container 152 .

[0216] First, the reading unit 211 reads the first motion data from the motion sequence list data 222 (S101). The motion data will be described later.

[0217] Next, the determination unit 212 determines whether to perform the first cleaning or the second cleaning based on the operation data ( S102 ).

[0218] When the first cleaning is performed ( S102 → first cleaning), the operation control unit 213 performs the first cleaning ( S103 ).

[0219] When the second cleaning is performed ( S102 → second cleaning), the operation control unit 213 performs the second cleaning ( S104 ).

[0220] When step S103 and step S104 are completed, the determination unit 212 determines whether all inspections are completed (S105). Specifically, the determination unit 212 determines whether all the operation data in the operation sequence list data 222 are completed.

[0221] When all checks have not been completed ( S105 →No), the processing unit 210 returns the process to step S101 and reads the next motion data.

[0222] When all the examinations are completed ( S105 →Yes), the processing unit 210 ends the aliquoting process for the specimen P in the specimen container 152 and performs the aliquoting process for the specimen P in the next specimen container 152 .

[0223] <Action Registration Data 221>

[0224] Figure 191 is a diagram showing an example of the action registration data 221 in the sixth embodiment.

[0225] like Figure 19 As shown, the test item registration area can be determined in advance for each reagent manufacturer, and whether the first cleaning or the second cleaning is performed in the test item registration area can be determined. In addition, for the first cleaning, a test item registration area that can be used in common by each reagent manufacturer can be secured in advance.

[0226] For example, in Figure 19 In the action registration data 221 shown, the area from "1001 address" to "1200 address" is the inspection item registration area of ​​"Company A". In addition, the area from "1201 address" to "1400 address" is the inspection item registration area of ​​"Company B". Figure 19 In the example, the area from "address 1901" to "address 2101" is the inspection item registration area for the first cleaning.

[0227] Each address in the action (reagent) distribution range is associated with a test item. For example, for "Company A," "Address 1001" stores the "AST" test. Similarly, "Address 1002" stores the "ALT" test. Similarly, for "Company B" and "Company C," the test items are associated with each address.

[0228] Furthermore, in the first cleansing inspection item registration area, a common address for "Company A," "Company B," "Company C," and so on is associated with each address. This means that the first cleansing is performed on the inspection item corresponding to the address stored in the first cleansing inspection item registration area. For example, "Address 1008" is stored in "Address 1901." Here, the first cleansing ("items affected by unstable component U") is performed on the inspection of "Company A" stored in "Address 1008." The same applies to "Address 1902" and beyond.

[0229] In addition, it is also possible to register "1008 Address A" as a new item in "1901 Address". For example, if we take the example of Company A, "1005 Address" is registered for the registered inspection item, and "1005 Address A" is registered in the inspection item registration area for the first clean. Here, "1005 Address" and "1005 Address A" represent inspection items that use the same reagent. And, as the inspection order, "1005 Address A" is set before "1005 Address". In this case, it is an inspection item that uses the same reagent, but after the inspection for the first clean is performed, the inspection for the second clean is performed (the reverse order can also be used). Thus, the first clean action and the second clean action can be performed in the same inspection item in the same specimen. That is, in the inspection using the reagent for the same inspection item, the first clean and the second clean can be performed. Such an action setting can be used generally, but can also be used for reagent development by reagent manufacturers. It is believed that by using it for reagent development by reagent manufacturers, it can contribute to reagent development.

[0230] Here, "items" refer to test items such as "ALT" and "HDL".

[0231] Furthermore, depending on the inspection content, the unstable component U may not affect the inspection. In such cases, the mid-way cleaning E1 is unnecessary. Therefore, as shown in the sixth embodiment, if the unstable component U does not affect the inspection, the mid-way cleaning E1 (second cleaning) is not performed. If the unstable component U does affect the inspection, the mid-way cleaning E1 (first cleaning) is performed. This eliminates the need for unnecessary mid-way cleaning E1, thereby improving inspection efficiency and reducing the consumption of cleaning water W.

[0232] Thus, by presetting the operation registration data 221, the controller 200 can distinguish between inspection items requiring the first cleaning and inspection items not requiring the first cleaning. The dispensing operation can be performed by the first cleaning only when the inspection items requiring the first cleaning are executed.

[0233] <Action Sequence List Data 222>

[0234] Figures 20A to 20C This is a diagram showing an example of the operation sequence list data 222 in the sixth embodiment.

[0235] exist Figures 20A to 20C In the example, an action sequence list data 222 shows that a pharmaceutical company (equivalent to Figure 19 Inspection of pharmaceuticals produced by "Company A", "Company B", "Company C" ...). Figures 20A to 20C The operation sequence list data 222 in FIG. 2 all use the pharmaceutical inspection of "Company A".

[0236] Figures 20A to 20C The action sequence list data 222 shown in FIG. 2 stores the order of the inspection items to be performed. Figure 20A In the example shown, the inspection is performed in the order of “items affected by the unstable component U” → “ALT” → “HDL” → … → “TP”. Figure 20B and Figure 20C Same here.

[0237] The determination unit 212 of the controller 200 uses the action data as a keyword to search Figure 19 The action registration data 221 is used to determine whether to perform the first cleaning ( Figure 18 Step S102). In addition, the action data refers to Figures 20A to 20C One record in the action sequence list data 222 is shown.

[0238] For example, Figure 20A As mentioned above, using the reagents from "Company A", the first inspection items are "items affected by the unstable component U", so according to Figure 19 The first cleaning is performed in this inspection according to the action registration data 221. The second cleaning is performed in another inspection.

[0239] In addition, Figures 20A to 20C In the inspection item column, the inspection item name is stored, but it is also possible to store Figure 19 The address in .

[0240] Here, the order of performing the first cleaning is Figure 20A In the example above, at the beginning of a series of checks, Figure 20B In the example of Figure 20C In the example, the last one is .

[0241] As described above, the unstable component U adheres to the outside of the sample probe 122 and is carried out. Therefore, if the sample P is repeatedly aspirated from the sample container 152 , the unstable component U decreases from the upper layer of the sample P.

[0242] That is, regarding the inspection items affected by unstable components, the first inspection is easily affected, and there is a tendency for the influence to decrease with the second half of the inspection. Figure 20A → Figure 20B → Figure 20C The order of reducing the mixing of the unstable component U in the first cleaning.

[0243] Therefore, by Figure 20C By performing the first washing last in this manner, the risk of the unstable component U being mixed into the sample discharged into the reaction container 131 can be reduced.

[0244] Here, inspection items requiring the first cleaning and inspection items not requiring the first cleaning are pre-set in the form of action registration data 221. However, the present invention is not limited to this, and a method of inspecting only inspection items requiring the first cleaning on an analysis parameter screen (not shown) for setting inspection items may also be used.

[0245] also, Figures 20A to 20C The virtual suction in refers to the following suction action. As described above, the specimen probe 122 is filled with system water. In addition, multiple inspections are continuously performed on the specimen P in one specimen container 152. That is, the specimen P is continuously dispensed from one specimen container 152 to multiple reaction containers 131. In such a case, it is preferable not to discharge all the specimen P in the specimen probe 122, but to leave a little specimen P in the specimen probe 122 after discharge. In this way, the specimen P will not be diluted by the system water in the specimen probe 122. That is, it is preferable to superfluously aspirate (virtually aspirate) the specimen P only during the initial aspiration.

[0246] Furthermore, the sample probe cleaning section 110 may be provided with a drying mechanism for drying the sample probe 122 .

[0247] In addition, in the present embodiment, the specimen probe 122 is rotationally moved, but may also be linearly moved or curvedly moved.

[0248] In this embodiment, the action registration data 221 and the action sequence list data 222 are stored in the storage unit 220 of the controller 200. However, the present invention is not limited thereto, and at least one of the action registration data 221 and the action sequence list data 222 may be stored external to the controller 200, such as in a cloud. In this case, the controller 200 obtains the necessary data from the external device.

[0249] The present invention is not limited to the embodiments described above and includes various variations. For example, the embodiments described above are described in detail to facilitate understanding of the present invention and are not limited to having all the structures described. In addition, a portion of the structure of a certain embodiment can be replaced with the structure of another embodiment, and the structure of another embodiment can be added to the structure of a certain embodiment. In addition, for a portion of the structure of each embodiment, other structures can be added, deleted, or replaced.

[0250] In addition, part or all of the above-mentioned structures, functions, units 210 to 213, storage unit 220, etc. may also be realized by hardware, for example, by designing an integrated circuit. Figure 17As shown, the various structures and functions described above can also be implemented by software by having a processor such as the CPU 252 interpret and execute programs that implement the various functions. Information such as programs, tables, and files that implement the various functions can be stored not only on a hard disk (HD) but also on a recording device such as the memory 251 or an SSD (Solid State Drive), or on a recording medium such as an IC (Integrated Circuit) card, an SD (Secure Digital) card, or a DVD (Digital Versatile Disc).

[0251] In addition, in each embodiment, the control lines and information lines are shown as those considered necessary for explanation, and not necessarily all the control lines and information lines on the product are shown. In fact, it can be considered that almost all the components are connected to each other.

[0252] Description of Reference Numerals

[0253] 1 Automatic analysis system

[0254] 100 Automatic analysis device (automatic analysis unit)

[0255] 110, 110A, 110B Specimen probe cleaning unit (cleaning unit)

[0256] 121 Sample dispensing unit (probe moving unit)

[0257] 122 specimen probe (probe unit)

[0258] 131 reaction vessel

[0259] 152 specimen container

[0260] 200 Controller (control unit, control device)

[0261] 211 Reading unit (acquisition unit)

[0262] 213 Motion Control Unit (Cleaning Control Unit)

[0263] 221 Action registration data (including information of the first and second inspections)

[0264] 222 Action sequence list data (including information of the first and second inspections)

[0265] E1, E11 mid-way cleaning (11th cleaning)

[0266] E2, E21~E24 Cleaning after dispensing (12th cleaning)

[0267] S101 Reading (acquisition step)

[0268] S103 1st cleaning (1st cleaning step)

[0269] S104 Second cleaning (second cleaning step)

[0270] v1 Rotational movement speed (1st movement speed)

[0271] v2 Rotational movement speed (second movement speed)

[0272] W cleaning water (cleaning fluid)

Claims

1. An automatic analysis system, characterized in that: have: Automatic analysis unit and control unit, The automatic analysis unit includes: a probe portion that performs suction and discharge of a specimen; and The cleaning section includes a probe moving section that moves the probe section at least from a position of a specimen container containing the specimen to a position of a reaction container into which the specimen is dispensed, and performs a first cleaning, wherein the first cleaning is performed by discharging a cleaning liquid around the probe section between sucking the specimen from the specimen container and discharging the specimen into the reaction container, and discharging the cleaning liquid around the probe section after discharging the specimen into the reaction container. The control unit controls the discharge and stop of the cleaning liquid in the first cleaning process for the item affected by the unstable component. When the inspection performed by the automatic analysis unit is the inspection affected by the unstable component, that is, the first inspection, the control unit causes the cleaning unit to perform the first cleaning. When the inspection performed by the automatic analysis unit is an inspection other than the first inspection, that is, a second inspection, the control unit causes the cleaning unit to perform a second cleaning. The second cleaning is that the cleaning liquid is not discharged to the outside of the probe unit between sucking the specimen from the specimen container and discharging the specimen into the reaction container, but the cleaning liquid is discharged around the probe unit after the specimen is discharged into the reaction container.

2. The automatic analysis system according to claim 1, characterized in that The control unit performs the first cleaning after performing all the second cleaning.

3. The automatic analysis system according to claim 1, characterized in that The control unit performs cleaning of the probe unit after stopping the movement of the probe unit in the first cleaning.

4. The automatic analysis system according to claim 3, characterized in that The cleaning portion discharges the cleaning liquid from the bottom to the top. The control unit discharges the cleaning liquid before the probe unit reaches the position of the cleaning unit during the first cleaning.

5. The automatic analysis system according to claim 1, characterized in that The control unit performs cleaning of the probe unit without stopping the movement of the probe unit during the first cleaning.

6. The automatic analysis system according to claim 5, characterized in that After starting the movement of the probe portion at a first movement speed which is a predetermined movement speed, the control portion sets the movement speed of the probe portion to a second movement speed which is slower than the first movement speed before cleaning the probe portion.

7. The automatic analysis system according to claim 1, characterized in that The control unit adjusts the suction time of the specimen in the probe unit according to the inspection performed by the automatic analysis unit. The control unit sets the cleaning time in the first cleaning to be longer as the suction time is shorter.

8. The automatic analysis system according to claim 1, characterized in that The control unit performs an 11th cleaning and a 12th cleaning during the first cleaning, wherein the 11th cleaning is to discharge cleaning liquid around the probe unit between sucking the specimen from the specimen container and discharging the specimen into the reaction container, and the 12th cleaning is to discharge cleaning liquid around the probe unit after the specimen is discharged into the reaction container. The first cleaning is divided into multiple cycles, The eleventh cleaning and the twelfth cleaning are performed in different cycles.

9. The automatic analysis system according to claim 8, characterized in that The eleventh cleaning and the twelfth cleaning are performed at the same timing in their respective execution cycles.

10. A control device in an automatic analysis system, The automatic analysis system comprises an automatic analysis device and the control device. The automatic analysis device comprises: a probe portion that performs suction and discharge of a specimen; and a cleaning unit including a probe moving unit for moving the probe unit at least from a position of a sample container containing the sample to a position of a reaction container into which the sample is dispensed, and discharging a cleaning liquid; The control device controls the discharge and stop of the cleaning liquid in the item affected by the unstable component. It is characterized in that The control device has: an acquisition unit that acquires information related to the inspection performed by the automatic analyzer; and A cleaning control unit that causes the cleaning unit to perform a first cleaning when the inspection performed by the automatic analyzer is the inspection affected by the unstable component, i.e., the first inspection, and causes the cleaning unit to perform a second cleaning when the inspection performed by the automatic analyzer is an inspection other than the first inspection, i.e., the second inspection, wherein the first cleaning is to discharge the cleaning liquid from the periphery of the probe unit between aspirating the specimen from the specimen container and discharging the specimen into the reaction container, and to discharge the cleaning liquid from the periphery of the probe unit after discharging the specimen into the reaction container, and the second cleaning is to not discharge the cleaning liquid from the outside of the probe unit between aspirating the specimen from the specimen container and discharging the specimen into the reaction container, but to discharge the cleaning liquid from the periphery of the probe unit after discharging the specimen into the reaction container.

11. A method for cleaning an automatic analysis system, characterized in that: The automatic analysis system comprises an automatic analysis device and a control device. The automatic analysis device comprises: a probe portion that performs suction and discharge of a specimen; and a cleaning unit including a probe moving unit for moving the probe unit at least from a position of a sample container containing the sample to a position of a reaction container into which the sample is dispensed, and discharging a cleaning liquid; The control device controls the discharge and stop of the cleaning liquid in the item affected by the unstable component. The control device performs: an acquisition step of acquiring information related to the inspection performed by the automatic analyzer; a first cleaning step of causing the cleaning unit to perform a first cleaning when the test to be performed by the automatic analyzer is the test to be affected by the unstable component, i.e., the first cleaning step of discharging a cleaning liquid around the probe unit between aspirating the specimen from the specimen container and discharging the specimen into the reaction container, and discharging the cleaning liquid around the probe unit after discharging the specimen into the reaction container; The second cleaning step is to cause the cleaning portion to perform a second cleaning when the inspection performed by the automatic analyzer is an inspection other than the first inspection, i.e., a second inspection. The second cleaning is to not discharge the cleaning liquid to the outside of the probe portion between sucking the specimen from the specimen container and discharging the specimen into the reaction container, but to discharge the cleaning liquid around the probe portion after discharging the specimen into the reaction container.

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