Preparation method for synthesizing 4, 4 '-difluorobenzophenone from fluorobenzene and reaction device of 4, 4'-difluorobenzophenone

Through the photochlorination and hydrolysis reaction of p-fluorotoluene, combined with the acylation and dripping device, the yield and purity of 4,4'-difluorobenzophenone were successfully improved, solving the problem of high preparation cost in the existing technology. problem, achieving an efficient and low-cost preparation process.

CN115108898AActive Publication Date: 2022-09-27ZHEJIANG SANMEI CHEM IND
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Patent Information

Application Number
CN202210775952.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2022-07-02
Publication Date
2022-09-27
Estimated Expiration
2042-07-02

AI Technical Summary

Technical Problem

The existing preparation methods of 4,4'-difluorobenzophenone have problems such as high production cost, low product purity and low yield, and are difficult to meet the needs of industrial production.

Method used

Using p-fluorotoluene as raw material, p-fluorotrichlorotoluene is synthesized through photochlorination reaction, and then hydrolyzed to synthesize p-fluorobenzoyl chloride. Finally, 4,4'-difluorobenzophenone is obtained through acylation reaction, and the dripping Devices and feed components improve reaction efficiency and product purity.

Benefits of technology

The product yield of 4,4'-difluorobenzophenone is achieved to reach more than 90%, and the purity reaches more than 99%, which reduces the preparation cost, simplifies the operation process, and improves the product quality.

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Abstract

The invention discloses a method for synthesizing 4, 5-difluorobenzene from fluorobenzene. According to the preparation method and the reaction device of the 4, 4 '-difluorobenzophenone, p-fluorotoluene is used as a raw material, p-fluorotrichlorotoluene is synthesized through a photochlorination reaction, p-fluorobenzoyl chloride is synthesized through hydrolysis, and finally the 4, 4'-difluorobenzophenone is prepared through an acylation reaction, the yield of the product reaches 90% or above, the purity reaches 99% or above, the preparation process is simple, and the method is suitable for industrial production. The preparation cost is obviously reduced while the product quality is improved. The photochlorination reaction is carried out in the reaction device, the feeding assembly has weighing and pushing functions, other weighing equipment does not need to be arranged, material loss caused by carrying after external weighing is prevented, the material adding accuracy is improved, and the product yield is further improved. And the gas inlet assembly of the reaction device realizes that chlorine is introduced from the bottom, moves from bottom to top in the reaction liquid and is in full contact with the reaction liquid, so that the collision probability between molecules is increased, and the yield of the product is further improved.
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