Motor neuromuscular vascular coupling function detection system

Abstract

The embodiment of the application discloses a motor nerve muscle blood vessel coupling function detection system, which comprises a muscle oxygen measurement module, which is covered on a to-be-detected part and is used for acquiring a muscle oxygen signal of the to-be-detected part under a motor stimulation, wherein the muscle of the to-be-detected part is associated with a target motor nerve; a processor, which is used for acquiring state time information; acquiring the muscle oxygen signal of the to-be-detected part under the motor stimulation through the muscle oxygen measurement module; determining a time response characteristic parameter of the muscle oxygen signal based on the state time information; and determining a motor nerve muscle blood vessel coupling analysis result of the to-be-detected part based on the time response characteristic parameter. The motor nerve muscle blood vessel coupling function cannot be used for detecting the motor nerve muscle blood vessel coupling function in the prior art.

Description

TECHNICAL FIELD

[0001] Embodiments of the present application relate to the field of medical devices, and in particular to a motor nerve muscle vascular coupling function detection system. BACKGROUND

[0002] Neurovascular coupling refers to that local nerve activity can cause an increase in local nerve blood supply, so that the nerve function activity can be judged by detecting the increase in local nerve blood flow. Motor nerves realize the movement function of the human body by dominating muscle contraction, and motor nerve damage can cause a decrease in human movement ability, and even loss of movement ability, so that motor nerve vascular coupling function evaluation has important physiological and medical significance.

[0003] In neuroscience, the method of detecting the increase in blood flow around the nerve by stimulating nerve activity is often used to evaluate the function of neurovascular coupling. Functional magnetic resonance imaging (fMRI) is a method that uses the principle of neurovascular coupling to reflect the region of brain nerve function activity by detecting the region of brain tissue blood flow change.

[0004] The existing neurovascular coupling function evaluation is generally applied to brain nerves, such as the fMRI technology described above. The brain nerve tissue is concentrated and has a large volume, and when the neurovascular coupling is evaluated, the nerve electrical recording electrode and the brain blood flow imaging device can be directly placed on the scalp or the brain tissue to obtain the nerve electrical activity and the blood flow information.

[0005] Although the peripheral nerve also has the physiological phenomenon of neurovascular coupling, the diameter of the peripheral nerve is less than 1 mm, and the peripheral nerve is embedded in the peripheral tissue, so it is difficult to non-invasively locate the position of the peripheral nerve and evaluate the neurovascular coupling function thereof. That is, the existing neurovascular coupling function cannot be used to detect the motor nerve muscle vascular coupling function. SUMMARY

[0006] Embodiments of the present application provide a motor nerve muscle vascular coupling function detection system, which solves the problem that the existing neurovascular coupling device cannot be used to detect the motor nerve muscle vascular coupling function.

[0007] In a first aspect, embodiments of the present application provide a motor nerve muscle vascular coupling function detection system, which comprises:

[0008] A muscle oxygen measurement module is covered on the to-be-detected part, and is used to obtain a muscle oxygen signal of the to-be-detected part under movement stimulation, wherein the muscle of the to-be-detected part is associated with a target motor nerve;

[0009] The processor is used for acquiring state time information; acquiring, through the muscle oxygen measurement module, a muscle oxygen signal of a to-be-tested part under motion stimulation; determining a time response characteristic parameter of the muscle oxygen signal based on the state time information; and determining a motion neuromuscular vascular coupling analysis result of the to-be-tested part based on the time response characteristic parameter.

[0010] The technical scheme provided by the embodiment of the present application acquires a muscle oxygen signal of a to-be-tested part under motion stimulation through a muscle oxygen measurement module, determines a time response characteristic parameter of the muscle oxygen signal according to acquired state time information, and determines a motion neuromuscular vascular coupling analysis structure of the to-be-tested part based on the time response characteristic parameter. The technical effect of detecting the motion neuromuscular vascular coupling function is achieved, and the system structure is simple and the cost is low. BRIEF DESCRIPTION OF DRAWINGS

[0011] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiment description. Obviously, the drawings in the following description are some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without any creative effort on the basis of these drawings.

[0012] Figure 1 is a structural block diagram of a motion neuromuscular vascular coupling function detection system provided by the embodiment of the present application;

[0013] Figure 2 is a structural schematic diagram of a muscle oxygen measurement module provided by the embodiment of the present application;

[0014] Figure 3 is a structural schematic diagram of another muscle oxygen measurement module provided by the embodiment of the present application;

[0015] Figure 4 is a characteristic absorption spectrum of deoxyhemoglobin and oxyhemoglobin provided by the embodiment of the present application;

[0016] Figure 5 is a structural block diagram of another motion neuromuscular vascular coupling function detection system provided by the embodiment of the present application;

[0017] Figure 6 is a combined structural schematic diagram of a muscle oxygen measurement module and a muscle oxygen measurement module provided by the embodiment of the present application;

[0018] Figure 7 is a structural schematic diagram of a paradigm limiting device provided by the embodiment of the present application;

[0019] Figure 8 is a structural block diagram of another motion neuromuscular vascular coupling function detection system provided by the embodiment of the present application. DETAILED DESCRIPTION

[0020] In order to make the objects, technical solutions and advantages of the present application clearer, the following will clearly and completely describe the technical solutions of the present application with reference to the accompanying drawings of the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by those of ordinary skill in the art without creative effort should fall within the scope of the present application.

[0021] Embodiment

[0022] Figure 1 is a structural schematic diagram of a motor nerve muscle vascular coupling function detection system provided by an embodiment of the present application. The technical solution of the embodiment is applicable to the case of in vivo detection of motor nerve muscle vascular coupling function. The system comprises a muscle oxygen measurement module 11 and a processor 12. The muscle oxygen measurement module 11 is overlaid on a to-be-detected part, and is used to acquire a muscle oxygen signal of the to-be-detected part under motor stimulation, wherein the muscle of the to-be-detected part is associated with a target motor nerve; the processor 12 is used to acquire state time information; the muscle oxygen measurement module is used to acquire the muscle oxygen signal of the to-be-detected part under the motor stimulation; a time response characteristic parameter of the muscle oxygen signal is determined; and a motor nerve muscle vascular coupling analysis result of the to-be-detected part is determined based on the time response characteristic parameter.

[0023] In the embodiment, the motor stimulation is muscle contraction stimulation. That is, the muscle oxygen measurement module is used to acquire the muscle oxygen signal of the to-be-detected part in a motor state. The single motor stimulation duration can be selected to be greater than or equal to 1 second.

[0024] In the embodiment, the target motor nerve is a peripheral motor nerve.

[0025] In the embodiment, the motor nerve muscle vascular coupling analysis result is a coupling result in a time dimension, and comprises a coupling parameter distributed with state time.

[0026] In one embodiment, as shown in Figure 2 the muscle oxygen measurement module 11 comprises one or more transmitting units 111 and one or more receiving units 112 arranged in the neighborhood of each transmitting unit 111; the processor 12 is used to acquire a triggering sequence of each transmitting unit 111 when a triggering signal is detected; based on a set timing, at least one transmitting unit 111 is controlled to output detection light of a set duration and a set wavelength according to the triggering sequence, and the receiving unit 112 in the neighborhood of the triggered at least one transmitting unit 111 is controlled to receive the muscle oxygen signal within the set duration. As an example, the identification sequence of the transmitting unit is taken as the triggering sequence.

[0027] For example, the muscle oxygen measurement module includes one emitting unit and four receiving units distributed around the emitting unit. Based on a set timing, the emitting unit is controlled to output detection light with a set time length and a wavelength of 850 nm and detection light with a set time length and a wavelength of 760 nm alternately, while the four receiving units are controlled to receive muscle oxygen signals regardless of the wavelength of the detection light output by the emitting unit. It can be understood that the four receiving units receive a first muscle oxygen signal when the emitting unit outputs detection light with a wavelength of 850 nm, and receive a second muscle oxygen signal when the emitting unit outputs detection light with a wavelength of 760 nm.

[0028] For example, as shown in Figure 2 the muscle oxygen measurement module includes at least two emitting units and at least two receiving units distributed around the emitting units. Any emitting unit is triggered twice in turn and is used to output detection light with a first set wavelength and detection light with a second set wavelength, respectively. The detection light with the first set wavelength corresponds to an oxyhemoglobin signal, and the detection light with the second set wavelength corresponds to a deoxyhemoglobin signal, or the detection light with the first set wavelength corresponds to a deoxyhemoglobin signal, and the detection light with the second set wavelength corresponds to an oxyhemoglobin signal.

[0029] In one embodiment, the muscle oxygen measurement module 11 includes at least two emitting units, which are arrayed to form an emitting unit array. The emitting unit array is divided into at least two regions, as shown in Figure 3 At any detection time, at least one emitting unit in each of the at least two regions is triggered. In this way, at least two emitting units of the muscle oxygen measurement module are triggered at the same detection time.

[0030] In one embodiment, the one or more emitting units and the receiving units corresponding to the one or more emitting units are arranged on a bottom film made of a flexible material.

[0031] The state time information is used to describe time information corresponding to different states of the patient. The time response characteristic parameters of the muscle oxygen signal include a response time and a response amplitude. Specifically, the time response characteristic parameters are determined based on a corresponding relationship between a hemoglobin concentration corresponding to the muscle oxygen signal and the state time information. The hemoglobin concentration determination method includes: the muscle oxygen measurement module uses near-infrared light with two different wavelengths (850 nm and 760 nm) to be incident into muscle tissue. Due to the characteristic absorption peaks of oxyhemoglobin (HbO2) and deoxyhemoglobin (HHb) in muscle tissue at 850 nm and 760 nm, as shown in Figure 4The two wavelengths of near infrared light are combined, and the concentrations of oxygenated hemoglobin and deoxygenated hemoglobin in the muscle tissue can be calculated according to the following algorithm:

[0032]

[0033]

[0034] where I' and I represent the intensity of the outgoing light and the incoming light, respectively. The subscripts λ1 and λ2 represent two different wavelengths of light, and ε HHb represent the light absorption coefficients of oxygenated hemoglobin and deoxygenated hemoglobin, respectively, and C HHb represent the concentrations of oxygenated hemoglobin and deoxygenated hemoglobin, respectively, r is the distance between the emitting unit and the receiving unit, DPF is the weight coefficient of the distance r, referred to as the differential path factor, and G is the light absorption coefficient of the tissue other than oxygenated hemoglobin and deoxygenated hemoglobin in the tissue. In the formula, and C HHb are the parameters to be solved, and other parameters except G are known. Since the absorption of light at each wavelength in the tissue is different, the use of two wavelengths of light to alternately irradiate the tissue to be measured can obtain two equations to solve the unknowns and C HHb After the emitting unit outputs the incoming light, the incoming light is received by the detector (receiving unit) after passing through an arc-shaped path in the tissue. The signal reflects the blood oxygen concentration information of all the muscle tissue through which the incoming light passes.

[0035] In one embodiment, the state time information is determined based on a state trigger signal input by a user. For example, the patient presses the trigger button when the muscle at the measurement site is contracted, at which time the indicator light corresponding to the trigger button is red, and the processor records the contraction start time according to the trigger signal output by the trigger button; the patient presses the trigger button again when the muscle at the measurement site is relaxed, at which time the indicator light corresponding to the trigger button is green, and the processor records the recovery start time according to the recovery start signal output by the trigger button, and determines the state time information according to at least one contraction start time and at least one recovery start time. It can be understood that the state time information is used to record the time period information of the measurement site of the patient in the motion state and the time period information of the measurement site of the patient in the rest state.

[0036] In one embodiment, as Figure 5 and Figure 6As shown, the system further comprises an electromyography measurement module 13, and the state time information is acquired based on the electromyography measurement module 13. Specifically, the electromyography measurement module 13 is configured to acquire the electromyography signal of the to-be-tested site under the motion stimulation; the processor 12 is further configured to, when any transmitting unit 111 is triggered, control all the electrodes 131 between the triggered transmitting unit 111 and the receiving units 112 adjacent to the transmitting unit 111 to output the stimulation current, so as to acquire the electromyography signal of the to-be-tested site; for each electrode channel, extract the evoked electrical signal in the electromyography signal, determine the state time information according to the evoked electrical signal, and determine the time response characteristic parameter of the muscle oxygen signal based on the state time information; and determine the motion neuromuscular vascular coupling analysis result of the to-be-tested site in the time dimension based on the time response characteristic parameter. It can be understood that the evoked electrical signal can be used to represent the switching of the muscle state, and thus the state time information of the to-be-tested site of the patient can be determined according to the evoked electrical signal.

[0037] In one embodiment, any electrode has the functions of outputting the stimulation current and collecting the electromyography signal. After the raw electromyography signal collected by the electrode is input into an amplification circuit, a shielding circuit and an analog-to-digital conversion (ADC) circuit in sequence, the analog signal is converted into a digital signal to generate the electromyography signal, and then the electromyography signal is transmitted to the upper computer through an optical fiber. The upper computer can be a personal computer, a workstation or a server. It can be understood that if the data processing of the electromyography signal is completed by a local processor, the electromyography signal output by the analog-to-digital conversion circuit is stored in a local memory to determine the corresponding time response characteristic parameter by the local processor.

[0038] In one embodiment, the processor is further configured to generate a muscle oxygen topographic map sequence according to a first set of characteristics of the muscle oxygen signal, and generate a muscle electromyography topographic map sequence according to a second set of characteristics of the muscle electromyography signal; determine the position difference parameter of the activated intensity at the same detection time in the muscle oxygen topographic map and the muscle electromyography topographic map; and determine the motion neuromuscular vascular coupling analysis result of the to-be-tested site in the spatial dimension according to the position difference parameter. The position difference parameter can be selected as a correlation coefficient, an activated area contrast or an activated position contrast. In combination with the foregoing embodiments, the motion neuromuscular vascular coupling analysis result of the to-be-tested site in the time dimension and the spatial dimension is determined.

[0039] The method for determining the muscle oxygenation topography map includes: preprocessing the muscle oxygenation signal to obtain an updated muscle oxygenation signal, the preprocessing including but not limited to filtering for removing physiological noise, system noise, and motion interference; and standardizing a first set feature value of the updated muscle oxygenation signal to generate a muscle oxygenation topography map. The first set feature value is the concentration of oxygenated hemoglobin, the concentration of deoxygenated hemoglobin, or blood oxygen saturation information at the measurement site. For example, the first set feature is blood oxygen content information. The standardized value of the blood oxygen saturation information is mapped to a set color, and spatial visualization of blood oxygen saturation is achieved using the spatial distribution of the receiving units, while temporal visualization is achieved using temporal changes.

[0040] The method for determining the electromyographic topographic map includes: preprocessing the electromyographic signal to update it, including but not limited to filtering; extracting features from the updated electromyographic signal to obtain a second set feature that reflects the electromyographic energy intensity; and normalizing the second set feature to a value between 0 and 1 to obtain the electromyographic topographic map. In this electromyographic topographic map, the second set feature can use different colors to represent different values; for example, red represents 1, blue represents 0, and the closer to 1, the redder it is, and the closer to 0, the bluer it is. Spatial visualization of the second set feature is achieved using the spatial distribution of the spatial electrode positions. It can be understood that temporal visualization of the second set feature can be achieved using time variations. The second set feature can be selected as a frequency domain feature or a time domain feature of the electromyographic signal. The time domain feature includes, but is not limited to, root mean square, integral value, average value, and standard deviation; the frequency domain feature includes, but is not limited to, average frequency and median frequency.

[0041] In one embodiment, such as Figure 6 As shown, one or more transmitting units and corresponding receiving units of the one or more transmitting units, as well as electrodes disposed between adjacent transmitting units and receiving units, are all disposed on a base film 10, which is made of a flexible material.

[0042] In one embodiment, the system further includes a paradigm-defining device comprising a body and a fixing structure disposed on the body, for fixing the body portion containing the test site to the body via the fixing structure, so that the posture of the body portion containing the test site remains unchanged under motion stimulation. The shape of the body varies depending on the test site. For example, Figure 7 The paradigm-limiting device 14 is adapted to the biceps brachii muscle, and its body includes a flat first portion 141 and a flat second portion 142 connected to one end of the first portion, wherein the included angle between the first portion 141 and the second portion 142 is α. Figure 7 The fixing structure 143 of the paradigm limiting device is a strap.

[0043] likeFigure 8 As shown, the system may optionally include a motion stimulus intensity detection device 15, which is used to acquire the motion stimulus intensity of the test site. The processor is also used to acquire a normalized benchmark, and to normalize the time response characteristic parameters based on the normalized benchmark and the motion stimulus intensity to update the time response characteristic parameters; and to determine the neuromuscular-vascular coupling analysis results of the test site based on the updated time response characteristic parameters. The motion stimulus intensity detection device may be a force detection device.

[0044] For example, placing the elbow on Figure 7 The paradigm-limiting device is positioned at the angle between the first and second parts of the apparatus. The forearm is secured to the main body with a strap. The hand grasps the handle of the force gauge (motor stimulus intensity detection device) and performs a wrist extension movement to contract the forearm flexor muscles. The force of the contraction is displayed and controlled by the force gauge. The paradigm-limiting device, used in conjunction with the motion stimulus intensity detection device, ensures that the same motion paradigm and contraction force can be repeated anytime, anywhere, and at any test site, thus standardizing the paradigm for assessing motor neuromuscular-vascular coupling function. This standardized motion stimulus improves the accuracy of motor neuromuscular-vascular coupling analysis results.

[0045] In one embodiment, a method for normalizing time response characteristic parameters based on a normalized benchmark and motion stimulus intensity includes: determining the ratio of motion stimulus intensity to a normalized benchmark, calculating the product of the ratio and the time response characteristic parameter, and using the product as the updated time response characteristic parameter.

[0046] In one embodiment, a method for normalizing a muscle oxygen signal based on a normalization benchmark and an exercise stimulus intensity includes: determining the ratio of the exercise stimulus intensity to the normalization benchmark, and calculating the product of the ratio and the muscle oxygen signal to update the muscle oxygen signal.

[0047] The normalization baseline is determined based on a baseline motor stimulus intensity. This baseline motor stimulus intensity is the average of at least two maximum contractile forces of the patient. For example, the test site is the biceps brachii. The patient grips the dynamometer with maximum force, and a first maximum grip force value is recorded. Then, the patient grips the dynamometer with maximum force again, and a second maximum grip force value is recorded. This process is repeated to measure at least two maximum grip forces of the patient, and the average of these at least two maximum grip forces is used as the normalization baseline.

[0048] In one embodiment, the processor is configured to acquire, by the muscle oxygenation measurement module 11, the muscle oxygenation signals of the to-be-tested site under different exercise stimulation intensities; determine the time response characteristic parameters of the muscle oxygenation signals corresponding to the different exercise stimulation intensities, and the mean value of the time response characteristic parameters of the muscle oxygenation signals corresponding to the different exercise stimulation intensities; and determine the exercise neuromuscular vascular coupling analysis result of the to-be-tested site based on the mean value. In this embodiment, the mean value of the time response characteristic parameters of the muscle oxygenation signals corresponding to the different exercise stimulation intensities is taken as the target time response characteristic parameter, and the exercise neuromuscular vascular coupling analysis result of the to-be-tested site is determined based on the target time response characteristic parameter, so that the error in a single measurement can be reduced, and the accuracy of the exercise neuromuscular vascular coupling analysis result can be improved.

[0049] In one embodiment, the processor is configured to: for each exercise stimulation intensity, determine the electromyography topography corresponding to each of the at least two first set features of the electromyography signal to obtain at least two electromyography topography sequences, and determine the muscle oxygenation topography corresponding to each of the at least two second set features of the muscle oxygenation signal to obtain at least two muscle oxygenation topography sequences; combine the at least two muscle oxygenation topography sequences with the at least two electromyography topography sequences in pairs; determine one exercise neuromuscular vascular coupling analysis result of the to-be-tested site in the spatial dimension according to each combination result; take the exercise neuromuscular vascular coupling analysis results under all exercise stimulations corresponding to each combination result as a group of exercise neuromuscular vascular coupling analysis results; and take the mean value of the group of exercise neuromuscular vascular coupling analysis results with the highest sensitivity to the exercise stimulation intensity from all groups of exercise neuromuscular vascular coupling analysis results as the expected exercise neuromuscular vascular coupling analysis result. The first set features can be selected as the frequency domain features or the time domain features of the electromyography signal. In this embodiment, one exercise neuromuscular vascular coupling analysis result of the to-be-tested site in the spatial dimension is determined according to each combination result, specifically: a sequence of position difference parameters of the activation intensity between the two topography sequences in each combination result is determined, and one exercise neuromuscular vascular coupling analysis result of the to-be-tested site in the spatial dimension is determined according to the sequence of position difference parameters.

[0050] The muscle oxygenation topography sequence includes muscle oxygenation topographies at at least two detection times, and the electromyography topography sequence includes electromyography topographies at at least two detection times. The different exercise stimulation intensities can be selected as 10% of the maximum contraction force, 30% of the maximum contraction force, 50% of the maximum contraction force, and 70% of the maximum contraction force. It can be understood that the first set features, the second set features, and the exercise stimulation intensities can be selected according to specific conditions in the actual use of the system. The exercise stimulation intensity sensitivity is the degree of change of the exercise neuromuscular vascular coupling analysis result with the exercise stimulation intensity, and it can be understood that the greater the degree of change, the greater the sensitivity to the exercise stimulation intensity.

[0051] The technical solution provided by this invention acquires the muscle oxygen signal of the test site under exercise stimulation through a muscle oxygenation measurement module, determines the time response characteristic parameters of the muscle oxygen signal based on the acquired state-time information, and determines the motor neuromuscular-vascular coupling analysis structure of the test site based on the time response characteristic parameters. This achieves the technical effect of detecting motor neuromuscular-vascular coupling function, and the system structure is simple and low-cost.

[0052] Note that the above description is merely a preferred embodiment of the present invention and the technical principles employed. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and various obvious changes, readjustments, and substitutions can be made without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in detail through the above embodiments, the present invention is not limited to the above embodiments, and may include many other equivalent embodiments without departing from the concept of the present invention, the scope of which is determined by the scope of the appended claims.

Claims

1. A system for detecting motor neuromuscular vascular coupling function, characterized in that, include: A muscle oxygenation measurement module, covering the test site, is used to acquire muscle oxygenation signals of the test site under exercise stimulation. The muscle oxygenation measurement module includes multiple transmitting units and one or more receiving units disposed in the vicinity of each of the multiple transmitting units. The muscles of the test site are associated with target motor nerves. An electromyography (EMG) measurement module includes electrodes disposed between each of the transmitting units and a receiving unit adjacent to each of the transmitting units, for acquiring EMG signals of the test site under motor stimulation. The processor is configured to acquire state-time information, including: when any transmitting unit is triggered, controlling all electrodes between the triggered transmitting unit and the receiving units in the vicinity of the transmitting unit to output stimulation current to acquire electromyographic signals of the test site; for each electrode channel, extracting evoked signals from the electromyographic signals, and determining state-time information based on the evoked signals, wherein the state-time information is used to record the time periods during which the patient's test site is in a moving state and the time periods during which it is in a resting state; The muscle oxygen measurement module acquires muscle oxygen signals from the test site under exercise stimulation, including: acquiring the triggering order of each transmitting unit when a triggering signal is detected; based on a set timing sequence, simultaneously controlling at least one transmitting unit to output detection light of a set duration and a set wavelength according to the triggering order; and controlling the receiving unit in the vicinity of the triggered at least one transmitting unit to receive the muscle oxygen signal within the set duration. Based on the state-time information, determine the time response characteristic parameters of the muscle oxygenation signal; based on the time response characteristic parameters, determine the motor neuromuscular vascular coupling analysis results of the test site in the time dimension; generate a muscle oxygenation topography sequence according to the first set feature of the muscle oxygenation signal, and generate an electromyography topography sequence according to the second set feature of the electromyography signal; determine the positional difference of activation intensity in the corresponding topography maps in the muscle oxygenation topography sequence and the electromyography topography sequence to obtain a positional difference parameter sequence; determine the motor neuromuscular vascular coupling analysis results of the test site in the spatial dimension based on the positional difference parameter sequence.

2. The system according to claim 1, characterized in that, Each transmitting unit is triggered twice in sequence, and is used to output detection light of a first set wavelength and a second set wavelength, respectively. The detection light of the first set wavelength corresponds to the oxyhemoglobin signal and the detection light of the second set wavelength corresponds to the deoxyhemoglobin signal, or the detection light of the first set wavelength corresponds to the deoxyhemoglobin signal and the detection light of the second set wavelength corresponds to the oxyhemoglobin signal.

3. The system according to claim 1, characterized in that, Also includes: A paradigm-limiting device includes a body and a fixing structure disposed on the body, for fixing the body part where the test site is located to the body through the fixing structure, so that the posture of the body part where the test site is located remains unchanged under motion stimulation.

4. The system according to claim 3, characterized in that, Also includes: A motion stimulus intensity detection device is used to obtain the motion stimulus intensity of the part to be tested; The processor is further configured to acquire a normalized baseline, and to normalize the time response characteristic parameter or the muscle oxygen signal based on the normalized baseline and the intensity of the exercise stimulus, so as to update the time response characteristic parameter or the muscle oxygen signal; and to determine the motor neuromuscular vascular coupling analysis result of the test site in the time dimension based on the updated time response characteristic parameter or the time response characteristic parameter corresponding to the updated muscle oxygen signal.

5. The system according to claim 4, characterized in that, The processor is used to acquire muscle oxygen signals of the test site under different exercise stimulation intensities through the muscle oxygen measurement module; determine the time response characteristic parameters of the muscle oxygen signals corresponding to different exercise stimulation intensities, and the mean value of the time response characteristic parameters of the muscle oxygen signals corresponding to different exercise stimulation intensities; and determine the motor neuromuscular vascular coupling analysis results of the test site in the time dimension based on the mean value.

6. The system according to claim 4, characterized in that, The processor is used for: For each intensity of exercise stimulus, at least two muscle oxygenation topographic maps corresponding to at least two first-defined features of the muscle oxygenation signal are determined to obtain at least two muscle oxygenation topographic map sequences, and at least two electromyographic topographic maps corresponding to at least two second-defined features of the electromyographic signal are determined to obtain at least two electromyographic topographic map sequences; the at least two muscle oxygenation topographic map sequences and the at least two electromyographic topographic map sequences are combined pairwise; based on each combination result, a motor neuromuscular vascular coupling analysis result of the test site in the spatial dimension is determined; The results of motor neuromuscular vascular coupling analysis under all motion stimuli corresponding to each combination result are regarded as a set of motor neuromuscular vascular coupling analysis results. The mean of the neuromuscular-vascular coupling analysis results of all groups with the highest sensitivity to the intensity of motion stimulation is taken as the expected neuromuscular-vascular coupling analysis result.

7. The system according to claim 5, characterized in that, The normalization benchmark is the mean of the patient's maximum contractile force at least twice.

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