In-situ sodium alginate hydrogel disposable gloves and preparation method thereof

Abstract

The present invention discloses the application of sodium alginate hydrogel in the in-situ preparation of disposable gloves, the disposable gloves prepared based on the above application, and a specific preparation method. The in-situ sodium alginate hydrogel disposable gloves of the present invention are formed by transferring the formation process of the sodium alginate hydrogel to the surface of a human hand, so that gloves that fit the shape of the hand are prepared, are easy to use, and the sodium alginate hydrogel is degradable and green and environmentally friendly.

Description

Technical Field

[0001] The invention belongs to the technical field of gloves, and particularly relates to an in-situ sodium alginate hydrogel disposable glove and a preparation method thereof. Background Art

[0002] Traditional disposable gloves, mostly plastic disposable gloves, latex disposable gloves, rubber disposable gloves, etc., are low in price and easy to use. They are widely used in food, medical, chemical, electronics and other fields.

[0003] However, these gloves are basically made by fixed molds. Although they have different specifications and sizes, they are still too large or too small when used, and it is difficult for them to fit perfectly with the hands of all users. In addition, most traditional disposable gloves are made of non-degradable materials such as plastic and rubber, which also bring a burden to the environment when manufactured and used in large quantities. Therefore, it is of great significance to design an environmentally friendly disposable glove that can fit perfectly with the hands. Summary of the invention

[0004] In view of this, in order to overcome the defects of the prior art, the purpose of the present invention is to provide an application of sodium alginate hydrogel in the in-situ preparation of disposable gloves and a specific preparation method, which can perfectly fit the shape of the hand, is easy to use, and the sodium alginate hydrogel is degradable and green and environmentally friendly.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] The invention provides application of sodium alginate hydrogel in in-situ preparation of disposable gloves.

[0007] The present invention also provides a disposable glove prepared based on the above application.

[0008] According to some preferred embodiments of the present invention, the disposable gloves are prepared by the following method:

[0009] Dissolving sodium alginate and a thickener in water to prepare a first solution; dissolving calcium chloride in water to prepare a second solution;

[0010] The first solution is evenly applied to the surface of the hand, and the second solution is sprayed on the surface of the first solution, the mass ratio of the first solution to the second solution is 1:1 to 1.1, and a disposable glove of sodium alginate hydrogel is prepared in situ. In some embodiments, the second solution can be sprayed on the surface of the first solution in the form of a spray, and the two solutions quickly form a hydrogel on the contact surface after contact, wrapping the entire hand and in close contact with the hand skin.

[0011] According to some preferred embodiments of the present invention, the disposable gloves are prepared by the following method:

[0012] Dissolving sodium alginate, thickener and calcium carbonate powder in water to prepare a first solution; dissolving gluconolactone in water to prepare a second solution;

[0013] The first solution and the second solution are mixed and applied to the hand surface, wherein the mass ratio of the first solution to the second solution is 1:1, and after the gel is formed, a disposable glove of sodium alginate hydrogel is prepared in situ. Gluconolactone will slowly hydrolyze and release H in aqueous solution. + , causing calcium carbonate to dissolve and release Ca 2+ This causes the sodium alginate to gel.

[0014] According to some preferred embodiments of the present invention, the viscosity of the first solution is 10,000 to 40,000 cp.s at 25°C.

[0015] According to some preferred embodiments of the present invention, the mass ratio of calcium chloride or calcium carbonate to sodium alginate is 0.3:1 to 0.8:1. The strength of the gloves obtained when the ratio is within this range is the best. The essence of gel formation is the chemical reaction between calcium ions and sodium alginate. If there are too few calcium ions, the gel strength is insufficient. If there are too many calcium ions, the gel strength is limited by the amount of sodium alginate and no further reaction occurs.

[0016] According to some preferred embodiments of the present invention, the concentration of sodium alginate in the first solution is 1% to 5%.

[0017] According to some preferred implementation aspects of the present invention, the concentration of calcium chloride is 1% to 5%. If the concentration is too low, the gel strength is insufficient. When the calcium chloride concentration is further increased, the gel performance does not change significantly, and too much addition will affect the final performance of the gloves. The mass concentration of calcium carbonate is 1% to 5%.

[0018] According to some preferred embodiments of the present invention, the concentration of gluconolactone in the second solution is calculated as a mass ratio of gluconolactone to calcium carbonate of 1:2 to 1:6.

[0019] According to some preferred embodiments of the present invention, the thickener is a combination of one or more of carbomer, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyethylene oxide, polyvinyl alcohol, and polyvinyl pyrrolidone. The thickener is a thickener commonly used in the cosmetics and daily chemical industries, and its function is to adjust the viscosity of the first solution so that it can be evenly attached to the surface of the hand and will not flow down, so that the apparent viscosity of the first solution is about 10000-40000 cp.s; if the viscosity is too low, the solution has good fluidity and cannot be attached to the surface of the hand, and if the viscosity is too high, the time required to prepare the solution is too long, which reduces production efficiency and is inconvenient to use.

[0020] According to some preferred embodiments of the present invention, the first solution and / or the second solution contains a disinfectant, which is a combination of one or more of medical alcohol, quaternary ammonium salts, benzalkonium chloride, triclosan, and polyhexamethylene biguanide. Whether to add and the concentration of addition can be determined according to the applicable occasions of the disposable gloves. If used in an environment requiring antibacterial treatment, at least the minimum antibacterial concentration needs to be reached.

[0021] The inventive principle of this application is as follows: Sodium alginate is a heteropolysaccharide composed of β-1,4-D mannuronic acid (M) and α-1,4,-D guluronic acid (G), and its molecule contains rich -COO - When divalent cations are added to the aqueous solution of sodium alginate, the Na + It will exchange with these divalent cations to form a three-dimensional network structure, causing the sodium alginate solution to transform into a gel. 2+ It has high chelating ability and low biological toxicity, and is a divalent cation suitable for preparing sodium alginate hydrogel. During the process of sodium alginate solution turning into gel, it is transferred to the surface of the hand to form a disposable glove that fits the hand in situ.

[0022] Due to the implementation of the above technical scheme, the present invention has the following advantages compared with the prior art: the in-situ sodium alginate hydrogel disposable gloves of the present invention are formed by transferring the formation process of the sodium alginate hydrogel to the surface of the human hand, so that the prepared sodium alginate hydrogel forms a glove that fits the shape of the hand, is easy to use, and the sodium alginate hydrogel is degradable and green and environmentally friendly. DETAILED DESCRIPTION

[0023] In order to enable those skilled in the art to better understand the technical solution of the present invention, the technical solution in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0024] Sodium alginate is a natural polysaccharide extracted from brown algae, which has good biocompatibility and biodegradability. Sodium alginate aqueous solution is easy to combine with divalent cations to form a gel. Based on this, the present invention provides an in-situ sodium alginate hydrogel disposable glove and a preparation method thereof, which is environmentally friendly and easy to use, and can fit the user's hand perfectly.

[0025] According to different usage modes (spraying or mixed coating), the preparation method of the in-situ disposable gloves of the present invention has the following two forms (the concentrations appearing below are by default mass concentrations):

[0026] The first preparation method comprises the following steps:

[0027] 1. Dissolve sodium alginate and thickener in water to prepare a first solution, the viscosity of the first solution is 10000-40000 cp.s (25°C). The concentration of sodium alginate is 1%-5%. If the concentration is too low, the gel layer will be too thin, and if it is too high, the solution viscosity will be too high, which is inconvenient to use.

[0028] 2. Dissolve calcium chloride and disinfectant in water to prepare a second solution. The concentration of calcium chloride is 1% to 5%. If the concentration is too low, the gel strength will be insufficient. When the concentration of calcium chloride is further increased, the gel performance will not change significantly, and adding too much will affect the final performance of the gloves. Different disinfectants require different concentrations, but at least the minimum inhibitory concentration can be reached.

[0029] 3. When in use, evenly apply the first solution on the hand surface, and then spray the second solution on the hand surface in the form of a spray, that is, a sodium alginate hydrogel disposable glove is prepared in situ on the hand surface. After the two solutions come into contact, hydrogel is quickly formed on the contact surface, wrapping the entire hand and in close contact with the hand skin.

[0030] Before use, it is best to clean and dry your hands to avoid severe dirt or excessive moisture that may affect the shaping and use of the gloves.

[0031] The second preparation method comprises the following steps:

[0032] 1. Dissolve and disperse sodium alginate, thickener, calcium carbonate powder and disinfectant in water to prepare a first solution, the viscosity of which is 10,000-40,000 cp.s (25°C). The mass concentration of sodium alginate is 1%-5%. If the concentration is too low, the gel layer will be too thin, and if it is too high, the solution viscosity will be too high and inconvenient to use; the mass concentration of calcium carbonate is 1%-5%. Different disinfectants have different concentrations, but at least the minimum inhibitory concentration can be reached.

[0033] 2. Dissolve gluconolactone in water to prepare a second solution. The concentration of gluconolactone in the second solution is calculated based on a mass ratio of gluconolactone to calcium carbonate of 1:2 to 1:6. Gluconolactone will slowly hydrolyze and release H in aqueous solution. + , causing calcium carbonate to dissolve and release Ca 2+ This causes the sodium alginate to gel.

[0034] 3. When in use, mix the first solution and the second solution and apply them to the surface of the hand. After the gel is formed, the sodium alginate hydrogel disposable gloves are prepared in situ on the surface of the hand.

[0035] Among them, the thickener is a thickener commonly used in the cosmetics and daily chemical industries, such as carbomer, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyethylene oxide, polyvinyl alcohol, polyvinyl pyrrolidone, etc., which is used to adjust the viscosity of the first solution so that it can be evenly attached to the surface of the hand and will not flow down. The concentrations required for different types of thickeners are generally different, so that the apparent viscosity of the first solution is controlled to be about 10,000 to 40,000 cp.s at 25°C. Disinfectants are medical alcohol, quaternary ammonium salts, benzalkonium chloride, triclosan, polyhexamethylene biguanide, etc. The concentrations required for different disinfectants are different, and at least the minimum inhibitory concentration can be reached.

[0036] The hydrogel prepared by the above method has a certain strength and contains a disinfectant component. While being used as a disposable glove, it also has the effect of cleaning and disinfecting the hands.

[0037] Example 1

[0038] The in-situ preparation of disposable gloves by sodium alginate hydrogel in this embodiment includes the following steps:

[0039] 1. Dissolve 3g of sodium alginate and 0.8g of thickener in 100mL of water to prepare a first solution, the viscosity of the first solution is 28000cp.s (25°C), and the concentration of sodium alginate is 2.9%.

[0040] 2. Dissolve 1.2 g of calcium chloride and 0.2 g of disinfectant in 100 mL of water to prepare a second solution, wherein the concentration of calcium chloride is 1.2% and the concentration of disinfectant is 0.2%.

[0041] 3. When in use, evenly apply the first solution on the hand surface, and then spray the second solution on the hand surface in the form of a spray. The amount of the second solution is 1.1 times that of the first solution, that is, the sodium alginate hydrogel disposable gloves are prepared in situ on the hand surface.

[0042] Example 2

[0043] The in-situ preparation of disposable gloves by sodium alginate hydrogel in this embodiment includes the following steps:

[0044] 1. Dissolve 2g of sodium alginate and 0.5g of thickener in 100mL of water to prepare a first solution, the viscosity of the first solution is 20000cp.s (25°C), and the concentration of sodium alginate is 2%.

[0045] 2. Dissolve 1.4 g of calcium chloride and 0.2 g of disinfectant in 100 mL of water to prepare a second solution, wherein the concentration of calcium chloride is 1.4% and the concentration of disinfectant is 0.2%.

[0046] 3. When in use, evenly apply the first solution on the surface of the hand, and then spray the second solution on the surface of the hand in the form of a spray. The amount of the second solution is 1.05 times that of the first solution, that is, the sodium alginate hydrogel disposable gloves are prepared in situ on the surface of the hand.

[0047] Example 3

[0048] The in-situ preparation of disposable gloves by sodium alginate hydrogel in this embodiment includes the following steps:

[0049] 1. Dissolve and disperse 3.5g sodium alginate, 0.5g thickener, 1.2g calcium carbonate powder and 0.2g disinfectant in 100mL water to prepare a first solution, the viscosity of which is 25000cp.s (25°C). The mass concentration of sodium alginate is 3.3%; the mass concentration of calcium carbonate is 1.1%.

[0050] 2. Dissolve 0.5 g of gluconolactone in 100 mL of water to prepare the second solution.

[0051] 3. When in use, mix the first solution and the second solution and apply them to the surface of the hand, wherein the mass ratio of the first solution to the second solution is 1:1. After the gel is formed, the sodium alginate hydrogel disposable gloves are prepared in situ on the surface of the hand.

[0052] Example 4

[0053] The in-situ preparation of disposable gloves by sodium alginate hydrogel in this embodiment includes the following steps:

[0054] 1. Dissolve and disperse 2.5g sodium alginate, 0.8g thickener, 1g calcium carbonate powder and 0.2g disinfectant in 100mL water to prepare a first solution, the viscosity of which is 26000cp.s (25°C). The mass concentration of sodium alginate is 2.5%; the mass concentration of calcium carbonate is 1%.

[0055] 2. Dissolve 0.3 g of gluconolactone in 100 mL of water to prepare the second solution.

[0056] 3. When in use, mix the first solution and the second solution and apply them to the surface of the hand, wherein the mass ratio of the first solution to the second solution is 1:1. After the gel is formed, the sodium alginate hydrogel disposable gloves are prepared in situ on the surface of the hand.

[0057] Comparative Example 1

[0058] The difference between this comparative example and Example 1 is that the concentration of calcium chloride in the second solution of this comparative example is 0.5%, resulting in insufficient gel strength and inability to form disposable gloves.

[0059] Comparative Example 2

[0060] The difference between this comparative example and Example 3 is that the concentration of gluconolactone in the second solution of this comparative example is too low, and the mass ratio of gluconolactone to calcium carbonate is 1:10, resulting in insufficient gel strength and inability to form disposable gloves.

[0061] Comparative Example 3

[0062] The difference between this comparative example and Example 3 is that the ratio of the first solution to the second solution is 3:1, that is, the proportion of the second solution is too low. The other formula components and preparation steps are basically the same as those of Example 3. The gel obtained in this comparative example is not strong enough to form a disposable glove.

[0063] Tests and Results

[0064] The preparation method in the embodiment was applied to the hand model, and the sample gloves were demoulded after forming, and the water impermeability and tensile properties were tested with reference to the method specified in GB24786-2009. The results are shown in Table 1.

[0065] Table 1 Test results

[0066] sample Waterproof Tensile strength(MPa) Example 1 qualified 18 Example 2 qualified 17 Example 3 qualified 22 Example 4 qualified 20 Commercially available polyethylene gloves qualified 17

[0067] Note: The commercially available gloves in the table are disposable polyethylene gloves produced by Haimen Yangzi Medical Instrument Co., Ltd.

[0068] It can be seen from the test results in Table 1 that the in-situ sodium alginate hydrogel disposable gloves prepared by the present invention can achieve the same or better impermeability and tensile strength as the existing commercially available disposable gloves, and can meet the needs of daily use.

[0069] The purpose of the present invention is to provide an in-situ sodium alginate hydrogel disposable glove, which is environmentally friendly and easy to use, and can fit the user's hand perfectly. The present invention adopts two methods: dissolving sodium alginate and a thickener in water to prepare a first solution; dissolving calcium chloride and a disinfectant in water to prepare a second solution. When in use, the first solution is evenly applied to the surface of the hand so that the surface of the hand is covered with a layer of sodium alginate solution, and then the second solution is sprayed on the surface of the hand in the form of a spray. After the two solutions come into contact, a hydrogel is quickly formed on the contact surface, which wraps the entire hand and is in close contact with the hand skin; or, sodium alginate, a thickener, calcium carbonate powder, and a disinfectant are dissolved in water and dispersed evenly to obtain a first solution, and gluconolactone is dissolved in a small amount of water to obtain a second solution. Before use, the first solution and the second solution are evenly mixed and applied to the surface of the hand. After the solution is gelled, the gel layer will wrap the entire hand and be in close contact with the hand skin; wherein gluconolactone will slowly hydrolyze and release H in the aqueous solution. + , causing calcium carbonate to dissolve and release Ca 2+Sodium alginate is gelled. The disposable gloves of the present invention can be generated in situ on the surface of the hand, perfectly fit the shape of the hand, and are easy to use, avoiding the problems of ordinary disposable gloves being difficult to wear and inappropriate in size; they are degradable sodium alginate hydrogels, green and environmentally friendly; functional materials can be added in appropriate amounts according to actual needs, such as adding disinfectants, and they also have the function of hand disinfection.

[0070] Although the present application is named as disposable gloves, it can also be used multiple times if various usage requirements are met.

[0071] The above embodiments are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with this technology to understand the contents of the present invention and implement them accordingly. They cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the protection scope of the present invention.

Claims

1. A sodium alginate hydrogel disposable glove, characterized in that; Sodium alginate hydrogel is used to prepare disposable gloves in situ, and the formation process of sodium alginate hydrogel is transferred to the surface of human hands to form a disposable glove of sodium alginate hydrogel in situ on the surface of the hand; The disposable gloves are prepared by the following method: Dissolving sodium alginate and a thickener in water to prepare a first solution; dissolving calcium chloride in water to prepare a second solution; After the first solution is evenly applied to the surface of the hand, the second solution is sprayed on the surface of the first solution to prepare a disposable glove of sodium alginate hydrogel in situ; or, The disposable gloves are prepared by the following method: Dissolving sodium alginate, thickener and calcium carbonate powder in water to prepare a first solution; dissolving gluconolactone in water to prepare a second solution; The first solution and the second solution are mixed evenly and then applied to the hand surface, and after the gel is formed, a disposable glove of sodium alginate hydrogel is prepared in situ; The viscosity of the first solution at 25° C. is 10,000 to 40,000 cp.s; The first solution and / or the second solution contains a disinfectant, and the disinfectant is a combination of one or more selected from medical alcohol, quaternary ammonium salt, benzalkonium chloride, triclosan, and polyhexamethylene biguanide; The concentration of sodium alginate in the first solution is 1% to 5%; the concentration of calcium chloride is 1% to 5%; the mass concentration of calcium carbonate is 1% to 5%; The concentration of gluconolactone in the second solution is calculated based on a mass ratio of gluconolactone to calcium carbonate of 1:2 to 1:

6.

2. The disposable glove according to claim 1, characterized in that: The mass ratio of the calcium chloride or calcium carbonate to the sodium alginate is 0.3:1 to 0.8:

1.

3. The disposable glove according to claim 1, characterized in that: The thickener is a combination of one or more selected from carbomer, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyethylene oxide, polyvinyl alcohol, and polyvinyl pyrrolidone.