A coagulation structure and a fitting device having the same

Abstract

The application relates to the technical field of medical devices, and provides a coagulation plug structure and a matching device with the same. The coagulation plug structure comprises a conveying piece, an attached plug piece, a first conductive piece and a second conductive piece. The attached plug piece has a folding state of being folded in a conveying cavity and a release state of being released from the conveying cavity after being subjected to external force. The distal end of the first conductive piece is connected with the proximal end of the attached plug piece. After the first conductive piece, the attached plug piece and the second conductive piece are connected with positive and negative ions in blood and a power supply, a current loop is formed, the coagulation plug structure forms a closed loop, a negative electrode is not needed to be punctured through the human body, the attached plug piece is positively charged after being electrified, a positive electric field is generated, blood electrophoresis with negative charges is attracted, and a blood clot is rapidly formed around the attached plug piece, so that the treatment time is shortened.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a thrombus structure and a matching device having the same. Background Technology

[0002] Interventional embolization is a common treatment for aneurysms. It usually involves inserting a microcatheter into the patient's body and using a delivery device to place embolic material into the aneurysm cavity through the microcatheter. This embolization reduces blood flow within the aneurysm, thereby achieving the goal of curing the aneurysm.

[0003] A spring coil electrocoagulation device is disclosed in the prior art, see [link to previous document]. Figure 1 and Figure 2 It includes at least a delivery steel tube and a microcatheter. The delivery steel tube delivers the release part 24, spring coil 25 and electrocoagulation wire 26 to the lesion site in the blood vessel through the microcatheter. The proximal end of the delivery steel tube 1 is inserted into the power supply port of an external power source. When the power switch is turned on, the release part 24 and the cathode spring 22 conduct the positive and negative electrode pathways through the electrolyte in the blood, forming a low-resistance circuit. The electrocoagulation wire 26 undergoes an electrolytic reaction to release iron ions. The iron ions react with proteins in the blood to form a thrombus. At the same time, the release part 24 undergoes an electrochemical reaction to dissolve and break, separating the spring coil 25 from the delivery rod, thereby achieving embolization treatment of the aneurysm.

[0004] However, during the use of this coil electrocoagulation device, due to the high blood flow velocity at the aneurysm, when the electrocoagulation wire 26 ionizes ferrous ions, the blood flow carries the ferrous ions from the aneurysm cavity into the blood vessel, making it difficult for the ferrous ions to be stably concentrated in the aneurysm cavity. Therefore, the number of ferrous ions in the aneurysm cavity will be relatively small, making it difficult to quickly form a stable thrombus in the aneurysm cavity. At the same time, the free ferrous ions may migrate into the microcatheter, forming a thrombus in the microcatheter and thus blocking the microcatheter, or even migrate into the blood and form a thrombus in the blood, leading to vascular embolism. Summary of the Invention

[0005] Therefore, the technical problem to be solved by the present invention is to overcome the defects in the existing spring coil electrocoagulation device, where, due to the fast blood flow velocity at the aneurysm, when the electrocoagulation wire ionizes ferrous ions, the blood flow carries the ferrous ions from the aneurysm cavity into the blood vessel, making it difficult for the ferrous ions to be stably concentrated in the aneurysm cavity. As a result, the number of ferrous ions in the aneurysm cavity is relatively small, making it difficult to quickly form a stable thrombus in the aneurysm cavity. At the same time, the free ferrous ions may migrate into the microcatheter, forming a thrombus in the microcatheter and thus blocking the microcatheter, or even migrate into the blood and form a thrombus in the blood, leading to vascular embolism. Therefore, the present invention provides a thrombus coagulation structure and an electrocoagulation device and release system having the same.

[0006] A plugging structure includes: a conveying member having a conveying cavity with open ends, the conveying cavity into which a first conductive member is adapted to extend and move along its axial direction; an attachment member, which, under the action of an external force, has a retracted state within the conveying cavity and a released state from the conveying cavity; and a first conductive member movably disposed with respect to the conveying cavity, the distal end of the first conductive member adapted to connect with the proximal end of the attachment member, the proximal end of the first conductive member adapted to be electrically connected to the positive terminal of a power source, and, under the action of an external force, the first conductive member... An electrical component is adapted to actuate the thrombus attachment from a retracted state to a released state; a second conductive component is adapted to be disposed around the outer peripheral surface of the conveyor along its axial direction, and its distal end is adapted to extend beyond the distal end of the conveyor, and the proximal end of the second conductive component is adapted to be electrically connected to the negative electrode of the power source; in the released state, the thrombus structure has a conductive state in which the first conductive component, the thrombus attachment, and the second conductive component are connected to positive and negative ions in the blood to conduct with the power source, so as to form a thrombus at the lesion site, and the thrombus attachment is adapted to adhere to the thrombus.

[0007] Optionally, in the above-described condensate structure, the second conductive element is wound around the axial direction of the conveying element to form a reinforcing layer with gaps;

[0008] It also includes a protective body adapted to fill the gaps in the reinforcing layer and wrap all the bodies of the conveying components and the body of the second conductive component, and to avoid the outer wall surface of the extension section of the second conductive component facing the first conductive component, so that the outer wall surface of the second conductive component facing the first conductive component is suitable to be exposed outside the protective body.

[0009] Optionally, in the above-described condensation structure, the distal wall thickness of the conveying member has a contraction section that gradually decreases from the proximal end to the distal end and a cylindrical section that smoothly transitions to the proximal end of the contraction section, wherein the wall thickness of the cylindrical section is consistent.

[0010] Optionally, in the above-described plug structure, at least one release point is adapted to be formed at the connection between the plug and the second conductive element. In the conductive state, all of the release points are adapted to melt to separate the plug from the second conductive element.

[0011] Optionally, in the above-mentioned condensate structure, the body material of the conveying component is one or more of fluoroplastics, nylon, and HDPE; and / or, the second conductive component is made of metal; and / or, the protective body is made of thermoplastic or rubber.

[0012] Optionally, in the above-described plug structure, the attachment is a spring coil, the proximal end of which is adapted to form a connecting portion bent toward the central axis of the spring coil, the end of which is disposed toward the proximal end of the spring coil and connected to the distal end of the first conductive element, so that all the release points are formed on the axis of the central axis of the spring coil.

[0013] Optionally, in the above-described plugging structure, at least one developing portion is provided on the outer surface of the second conductive element.

[0014] Optionally, in the above-described thrombus structure, the developing section is made of metal.

[0015] Optionally, in the above-mentioned condensate structure, the first conductive element is made of metal, and its outer surface is suitable for coating with an insulating layer.

[0016] Optionally, in the above-mentioned plug structure, the insulating layer is made of PTFE or parylene.

[0017] A fitting device includes: a power source; a plug structure, the plug structure being as described above, wherein a second conductive element of the plug structure is connected to the negative terminal of the power source, and a first conductive element is connected to the positive terminal of the power source.

[0018] The technical solution of this invention has the following advantages:

[0019] 1. The present invention provides a thrombus-forming structure, comprising: a conveying member having a conveying cavity with open ends, the conveying cavity being adapted for a first conductive member to extend into and move along its axial direction; an attachment member, subjected to an external force, the attachment member having a retracted state within the conveying cavity and a released state released from the conveying cavity; a first conductive member movably disposed with the conveying cavity, the distal end of the first conductive member being adapted to connect to the proximal end of the attachment member, the proximal end of the first conductive member being adapted to be electrically connected to the positive terminal of a power source, and under the action of an external force, the attachment member... The first conductive element is adapted to push the thrombus attachment from a retracted state to a released state; the second conductive element is adapted to be disposed around the outer peripheral surface of the conveying element along the axial direction of the conveying element, and its distal end is adapted to extend beyond the distal end of the conveying element, and the proximal end of the second conductive element is adapted to be electrically connected to the negative electrode of the power source; in the released state, the thrombus structure has a conductive state in which the first conductive element, the thrombus attachment, and the second conductive element are connected to positive and negative ions in the blood to conduct with the power source, so as to form a thrombus at the lesion site, and the thrombus attachment is adapted to adhere to the thrombus.

[0020] In this thrombus-forming structure, when the thrombus attachment is in the released state, a conductive current loop is formed by connecting the first conductive element, the thrombus attachment, the second conductive element, and the positive and negative ions in the blood to a power source. This achieves the effect of forming a closed loop in the thrombus-forming structure, eliminating the need for a negative electrode through human puncture. The thrombus attachment, after being energized, becomes positively charged, generating a positive electric field that attracts negatively charged blood electrophoresis, thus rapidly forming a thrombus around the thrombus attachment, shortening treatment time. During the thrombus-forming process, the thrombus attachment is located at the lesion site, generating an electric field there. Negatively charged blood is directionally attracted to the location of the thrombus attachment, forming a thrombus at that location. This prevents thrombus formation at other locations besides the lesion site. The device achieves stable adhesion of the thrombus by discharging the entire thrombus attachment, thus increasing the adhesion area and ensuring stable thrombus attachment. This overcomes the shortcomings of existing coil electrocoagulation devices, where the rapid blood flow at the aneurysm causes the ferrous ions to be flushed out of the aneurysm lumen into the blood vessel after ionization. This makes it difficult for the ferrous ions to concentrate stably in the aneurysm lumen, resulting in a smaller number of ferrous ions and hindering the rapid formation of a stable thrombus. Furthermore, the free ferrous ions may migrate into the microcatheter, forming thrombi that block the microcatheter, or even migrate into the bloodstream, causing vascular embolism.

[0021] 2. In the condensate structure provided by the present invention, the second conductive element is wound around the axial direction of the conveying element to form a reinforcing layer with gaps; it also includes a protective body, which is adapted to fill the gaps in the reinforcing layer and wrap all the bodies of the conveying element and the body of the second conductive element, and is disposed away from the outer wall surface of the first conductive element on the extension section of the second conductive element, so that one end face of the second conductive element facing the first conductive element is adapted to be exposed outside the protective body.

[0022] In this condensation structure, the second conductive element is wound around the conveying element to form a reinforcing layer with gaps. Then, the protective body fills the gaps and wraps the body of the conveying element and the body of the second conductive element, thereby increasing the overall strength of the condensation structure.

[0023] 3. In the thrombus-coating structure provided by the present invention, the first conductive element is made of metal, and its outer surface is suitable for coating with an insulating layer. By coating the outer surface of the first conductive element with an insulating layer, thrombus formation on the first conductive element is prevented after energization, and thrombi already formed around the thrombus attachment element are not carried out, thus preventing thrombus escape. Attached Figure Description

[0024] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0025] Figure 1 This is a schematic diagram of the spring coil structure in an existing electrocoagulation device.

[0026] Figure 2 This is a schematic diagram showing the positional structure of the release part and the cathode spring in the prior art.

[0027] Figure 3 This is a schematic diagram of the condensate plug structure and power supply connection provided in the first embodiment of the present invention;

[0028] Figure 4 for Figure 3 The diagram shows an enlarged view of the structure at point A.

[0029] Figure 5 This is a schematic diagram of a thrombus-like structure inserted into a lesion site.

[0030] Explanation of reference numerals in the attached figures:

[0031] 1. Conveying component; 101. Conveying cavity; 102. Contraction section; 103. Cylindrical section;

[0032] 2. Attached bolts; 201. Connecting parts;

[0033] 3. First conductive component; 4. Second conductive component;

[0034] 5. Protect the main body; 6. Release point; 7. Developing section;

[0035] 8. Power supply. Detailed Implementation

[0036] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0037] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0038] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0039] Furthermore, the technical features involved in the different embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0040] In this invention, "proximal end" and "far end" refer to the end relative to the operator's operating end. The end closer to the operator's operating end is the proximal end, and the end farther away from the operator's operating end is the far end.

[0041] Example 1

[0042] This embodiment describes a thrombus structure; see [link to documentation]. Figures 3-5 The throttle structure includes a conveying component 1, an attachment component 2, a first conductive component 3, and a second conductive component 4. The conveying component 1 has a conveying cavity 101 with open ends. The first conductive component 3 extends into the conveying cavity 101 and is movable along the axial direction of the conveying cavity 101. When the attachment component 2 is subjected to external force, it has a retracted state within the conveying cavity 101 and a released state from the conveying cavity 101. The distal end of the first conductive component 3 is connected to the proximal end of the attachment component 2, and the proximal end of the first conductive component 3 is electrically connected to the positive terminal of the power supply 8. When an external force is applied to the first conductive component 3, the first conductive component 3 is adapted to push the attachment component 2 from the retracted state to the released state, thereby releasing the attachment component 2.

[0043] The second conductive element 4 is wound around the outer peripheral surface of the conveying element 1 along the axial direction of the conveying element 1, and the distal end of the second conductive element 4 is adapted to extend beyond the distal end of the conveying element 1 as an extension section. The proximal end of the second conductive element 4 is adapted to be electrically connected to the negative terminal of the power supply 8.

[0044] In the released state, the thrombus structure has a first conductive element 3, an attachment element 2, and a second conductive element 4 connected to positive and negative ions in the blood to conduct to the power source 8, so as to form a thrombus at the lesion site, and the attachment element 2 is suitable for attaching the thrombus.

[0045] When the thrombectomy piece 2 is in the released state, by connecting the first conductive piece 3, the thrombectomy piece 2, and the second conductive piece 4 with the positive and negative ions in the blood and the power source 8, a conductive current loop can be formed, achieving the effect of forming a closed loop in the thrombus structure. It is not necessary to use human puncture to create a negative electrode. The thrombectomy piece 2 is positively charged after being energized, thereby generating a positive electric field that can attract negatively charged blood electrophoresis, thus rapidly forming a thrombus around the thrombectomy piece 2, shortening the treatment time. During the thrombus formation process, the thrombectomy piece 2 is located at the lesion site, and it generates an electric field at the lesion site. Negatively charged blood is attracted in a direction to the position of the thrombectomy piece 2, so that a thrombus is formed at the thrombectomy piece 2. Therefore, thrombi will not form in other locations besides the lesion site. The thrombus formation position is stable. At the same time, due to the overall discharge of the thrombectomy piece 2, the attachment area of ​​the thrombus is increased, achieving the effect of stable attachment of the thrombus to the thrombectomy piece 2.

[0046] In this embodiment, to improve the strength of the slug structure, after the second conductive element 4 is wound around the outer peripheral surface of the conveyor 1 along its axial direction, it forms a reinforcing layer with gaps. At the same time, the slug structure also includes a protective body 5, which is adapted to fill the gaps in the reinforcing layer and wrap all the bodies of the conveyor 1 and the second conductive element 4. During the wrapping process, the upper surface of the extension of the second conductive element 4 facing the outer wall of the first conductive element is avoided, so that the outer wall surface of the second conductive element 4 facing the first conductive element 3 is exposed outside the protective body 5. In the conductive circuit of the slug structure, since the outer wall surface of the second conductive element 4 facing the first conductive element 3 is exposed outside the protective body 5, it participates in the conductive circuit, achieving the effect of a conductive circuit while improving the strength of the slug structure.

[0047] Specifically, the second conductive element 4 can be made of single braid or coil winding, or it can be a composite of braid and coil winding to form a reinforcing layer.

[0048] In this embodiment, the conveying component 1 can be configured as a constriction section 102 and a cylindrical section 103 from the far end to the near end. The near end of the constriction section 102 and the far end of the cylindrical section 103 are smoothly transitioned. The wall thickness of the constriction section 102 gradually decreases from the near end to the far end, while the wall thickness of the cylindrical section 103 is uniform, which facilitates the forming of the conveying component 1.

[0049] In this embodiment, at least one release point 6 can be formed at the connection between the attachment 2 and the first conductive element 3. In the conductive state, all release points 6 are suitable for melting to separate the attachment 2 from the first conductive element 3 and complete the release of the attachment 2. The size of the release point 6 is designed according to the actual energizing time and current requirements.

[0050] In this embodiment, in specific applications, the body material of the above-mentioned conveying component 1 can be one or more of fluoroplastics, nylon, and HDPE, the second conductive component 4 can be made of metal, such as stainless steel, nickel titanium, tungsten steel, gold, platinum, and platinum nickel, and the protective body 5 can be made of thermoplastic plastic or rubber, such as TPU, TPE, Pebax, and PA. Of course, it is not limited to these, as long as the corresponding effect can be achieved.

[0051] In practical applications, the aforementioned attachment 2 can be set as a spring ring, with the proximal end of the spring ring adapted to form a connecting portion 201 bent toward the central axis of the spring ring. The end point of the connecting portion 201 is set toward the proximal end of the spring ring and connected to the distal end of the first conductive member 3, so that all release points 6 are formed on the axis of the central axis of the spring ring. The spring ring can be made of inert metals such as gold and platinum or corresponding alloys. Of course, the attachment 2 can also be a bracket, and the appropriate settings can be made according to the specific use.

[0052] In this embodiment, at least one developing part 7 is provided on the outer surface of the second conductive element 4. The developing part 7 is made of metal, such as platinum-iridium, platinum, or gold, but is not limited to these materials, as long as it can achieve the developing effect.

[0053] In this embodiment, the first conductive element 3 is made of metal and its outer surface is suitable for coating with an insulating layer. The insulating layer is made of PTFE. The insulating layer can prevent the formation of thrombi on the first conductive element 3 after energization, and at the same time, it will not carry out the thrombi that have formed around the attachment element 2, thus preventing the thrombi from escaping. Meanwhile, the second conductive element 3 can form a negative electric field in the exposed part at the far end of the conveying element 1, thus preventing the formation of thrombi at the far end opening of the conveying element 1, the release point 6, and the exposed part.

[0054] In this embodiment, in order to further stabilize the thrombus in practical applications, cilia can be provided on the thrombus attachment 2. The cilia play a role in quickly forming the thrombus, stabilizing the thrombus, and protecting the aneurysm wall, so as to prevent the charged spring coil from directly contacting the aneurysm wall and causing harm to the aneurysm.

[0055] Example 2:

[0056] This embodiment describes a mating device; see [link / reference] Figure 1 It includes a power supply 8 and a plug structure, wherein the plug structure is the plug structure described in Example 1, the second conductive element 4 of the plug structure is connected to the negative terminal of the power supply 8, and the first conductive element 3 is connected to the positive terminal of the power supply 8.

[0057] The electrocoagulation device in this embodiment has a good coagulation effect, a simple structure, and is easy to promote and use.

[0058] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A type of plug structure, characterized in that, include: The conveying member (1) has a conveying cavity (101) with openings at both ends, the conveying cavity (101) being adapted to extend into and move along its axial direction of the first conductive member (3); The attached bolt (2) is subjected to external force and has a retracted state that is closed within the conveying cavity (101) and a released state that is released from the conveying cavity (101); The first conductive element (3) is movably disposed with the conveying cavity (101). The distal end of the first conductive element (3) is adapted to be connected to the proximal end of the attachment (2). The proximal end of the first conductive element (3) is adapted to be electrically connected to the positive pole of the power supply (8). Under the drive of external force, the first conductive element (3) is adapted to push the attachment (2) from the retracted state to the released state. The second conductive element (4) is adapted to be wound around the outer circumferential surface of the conveying element (1) along the axial direction, and its distal end is adapted to extend beyond the distal end of the conveying element (1), and the proximal end of the second conductive element (4) is adapted to be electrically connected to the negative terminal of the power supply (8). In the released state, the thrombus structure has a conductive state in which the first conductive element (3), the attached thrombus element (2), and the second conductive element (4) are connected to positive and negative ions in the blood to conduct with the power source (8) so as to form a thrombus at the lesion site, and the attached thrombus element (2) is adapted to attach the thrombus.

2. The thrombus structure according to claim 1, characterized in that, The second conductive element (4) is wound along the axial direction of the conveying element (1) to form a reinforcing layer with gaps; It also includes a protective body (5), which is adapted to fill the gap in the reinforcing layer and wrap all the bodies of the conveying members (1) and the body of the second conductive member (4), and is disposed away from the outer wall surface of the extension of the second conductive member (4) facing the first conductive member, so that the outer wall surface of the second conductive member (4) facing the first conductive member (3) is adapted to be exposed outside the protective body (5).

3. The condensate structure according to claim 2, characterized in that, The distal wall thickness of the conveying member (1) has a contraction section (102) that gradually decreases from the proximal end to the distal end and a cylindrical section (103) that smoothly transitions to the proximal end of the contraction section (102), the cylindrical section (103) having a uniform wall thickness.

4. The condensate structure according to claim 3, characterized in that, At least one release point (6) is adapted to be formed at the connection between the attachment (2) and the first conductive element (3), and in the conductive state, all of the release points (6) are adapted to melt to separate the attachment (2) from the first conductive element (3).

5. The condensate structure according to any one of claims 2-4, characterized in that, The body material of the conveying component (1) is one or more of fluoroplastic, nylon, and HDPE; and / or, the second conductive component (4) is made of metal; and / or, the protective body (5) is made of thermoplastic or rubber.

6. The thrombus structure according to claim 4, characterized in that, The attachment (2) is a spring coil, the proximal end of which is adapted to form a connecting portion that bends toward the central axis of the spring coil. The end of the connecting portion is disposed toward the proximal end of the spring coil and is connected to the distal end of the first conductive element (3) so that all the release points (6) are formed on the axis of the central axis of the spring coil.

7. The condensate structure according to any one of claims 1-4 or 6, characterized in that, At least one developing portion (7) is provided on the outer surface of the second conductive element (4).

8. The condensate plug structure according to claim 7, characterized in that, The developing section (7) is made of metal.

9. The condensate plug structure according to claim 8, characterized in that, The first conductive element (3) is made of metal and its outer surface is suitable for coating with an insulating layer.

10. The condensate structure according to claim 9, characterized in that, The insulating layer is made of PTFE or parylene.

11. A mating device, characterized in that, include: Power supply (8); A plugging structure, wherein the plugging structure is as described in any one of claims 1-10, wherein the second conductive element (4) of the plugging structure is connected to the negative terminal of the power supply (8), and the first conductive element (3) is connected to the positive terminal of the power supply (8).

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