A mouse bone marrow cavity puncture fixation and positioning aid device

Abstract

This application discloses a mouse medullary cavity puncture fixation auxiliary positioning device, belonging to the field of medical auxiliary devices. It includes an operating table, lifting plates, a length measuring component, and a puncture fixation device. Two lifting plates are provided, positioned on both sides of the operating table with their bottoms connected to the top of the operating table. The puncture fixation device is positioned between the two lifting plates and located on one side of the operating table. The puncture fixation device includes an auxiliary fixation component and a limiting puncture component, both positioned between the two lifting plates. Length measuring components for measuring femurs of different lengths are provided on both sides of the two lifting plates. This device enables real-time adjustment and fixation according to different femur sizes during puncture and allows for precise positioning and drug delivery to the mouse's medullary cavity.

Description

Technical Field

[0001] This application relates to the field of medical assistive devices, and in particular to a mouse bone marrow cavity puncture fixation and positioning auxiliary device. Background Technology

[0002] Bone marrow aspiration is a commonly used diagnostic technique in clinical practice for extracting bone marrow fluid. When constructing mouse leukemia or osteomyelitis models, we need to collect bone marrow fluid from mice for data analysis in order to monitor the proliferation of mouse bone marrow over a long period of time.

[0003] In existing technologies, intramedullary puncture for drug administration is a common procedure in mouse bone marrow collection experiments. However, mouse femurs vary in size and are prone to fracture, and the medullary cavity of the femur is relatively small. Existing positioning devices cannot be adjusted and fixed in real time according to different femur sizes, thus failing to achieve precise positioning and drug administration. In actual puncture operations, the needle is prone to protruding from the side, causing bone damage to the mouse, causing pain, and leading to experimental failure. This results in a significant waste of experimental materials and animals. Furthermore, there is no way to determine the success of the experiment after puncture, or whether the model was established and the drug reached the medullary cavity, which creates considerable difficulties in the experimental process and affects the success rate. Therefore, there is a need for a device that can be adjusted and fixed in real time according to different femur sizes during puncture and can accurately position and administer drugs to the mouse's medullary cavity.

[0004] Application content

[0005] This application provides a mouse bone marrow cavity puncture fixation and positioning auxiliary device to solve the aforementioned technical problems.

[0006] The embodiments of this application adopt the following technical solution: including an operating table, a lifting plate, a length measuring component, and a puncture fixation device. There are two lifting plates, which are arranged on both sides of the operating table and connected at the bottom to the top of the operating table. The puncture fixation device is arranged between the two lifting plates and located on one side of the operating table. The puncture fixation device includes an auxiliary fixation component and a limiting puncture component. Both the auxiliary fixation component and the limiting puncture component are arranged between the two lifting plates. Length measuring components for measuring femoral lengths of different lengths are provided on both sides of the two lifting plates.

[0007] Furthermore, the length measuring component includes a fixed frame, sliding wheels, and an electric push rod. The sliding wheels are provided in several pairs, symmetrically arranged in pairs on the opposite side of the lifting plate and fixedly connected thereto. Each sliding wheel has a fixed frame vertically to the ground at its side end, which slides up and down with it. The electric push rod is vertically arranged at the bottom of the operating table, and the output end of the electric push rod is connected to the bottom of the operating table.

[0008] Furthermore, the auxiliary fixing assembly includes an adjustment box, a drive gear, a drive shaft, a drive rack, a first drive rod, a second drive rod, a sliding shaft, an arc-shaped clamping plate, and a drive motor. The adjustment box is located at the bottom of one side of the operating table and is fixedly connected to it. The drive shaft is located inside the limiting box, and both ends of the drive shaft are rotatably connected to the side ends of the adjustment box. Two drive racks are provided, located on the upper and lower sides of the drive shaft and slidingly engaged with the inner wall of the limiting box. The drive gear is located on the drive shaft and is fixedly connected to it. The toothed ends of the first and second drive rods are respectively engaged with the drive gear. The first and second drive rods are respectively located at the ends of the two drive racks away from the drive gears. The tops of the first and second drive rods are on the same horizontal line and are located on the opposite sides of the two lifting plates. The tops of the first and second drive rods are each provided with a horizontally arranged sliding shaft and fixedly connected to it. One end of each of the two sliding shafts passes through the lifting plate and slides with it. An arc-shaped clamping plate is provided at the adjacent ends of the two sliding shafts. The two arc-shaped clamping plates are arranged symmetrically. The drive motor is located outside the adjustment box, and the output end of the drive motor is connected to one end of the drive shaft.

[0009] Furthermore, the limiting puncture assembly includes an adjusting plate, a telescopic sleeve, an adjusting rod, a slider, a needle sleeve, a puncture needle, and a fixing knob. The adjusting plate is positioned between two lifting plates and on one side of the operating table. Both ends of the adjusting plate are fixedly connected to one of the lifting plates. The adjusting plate has a sliding groove for the telescopic sleeve to slide in. The telescopic sleeve is located in the sliding groove. The telescopic rod is located inside the telescopic sleeve and threadedly connected to it. One end of the adjusting rod is fixedly connected to a slider. The bottom of the slider is higher than the top of the two curved clamps. The needle sleeve is vertically mounted on the slider with its output end facing downwards. The puncture needle is located inside the needle sleeve. The slider has a through-hole that matches the puncture needle. The fixing knob is located on the side of the adjusting plate away from the slider and is fixedly connected to one end of the adjusting rod. The fixing knob has several limiting blocks for fixing the sliding of the telescopic sleeve. The side of the adjusting plate away from the slider has several limiting grooves that fit the shape of the limiting blocks.

[0010] Furthermore, each of the aforementioned fixing brackets has a scale perpendicular to the operating table on the side away from the operating table, and the slider has a scale parallel to the operating table on the side away from the arc-shaped clamp, with the 0 mark of the scale located in the center.

[0011] Furthermore, the surface of the fixed knob is provided with anti-slip texture.

[0012] The above-described technical solutions adopted in the embodiments of this application can achieve the following beneficial effects:

[0013] Firstly, when it is necessary to perform puncture and drug administration into the medullary cavity of a mouse, the mouse is placed on the operating table with one side of the femoral medullary cavity positioned in the puncture fixation device. The height of the lifting plate is adjusted according to the length of the mouse femur using the length measuring component, thereby adjusting the height of the operating table so that one end of the mouse femur can rest flat on the operating table. This fixes the height of the mouse femoral medullary cavity, ensuring that the medullary cavity faces the output end of the limiting puncture component. This prevents the medullary cavity from sliding up and down during medullary cavity puncture. Then, depending on the thickness of the mouse femur, the auxiliary fixation component is used to further adjust the position of the mouse's femur. The femur is laterally clamped to achieve lateral fixation, ensuring the mouse's femur is perpendicular to the ground for easy manipulation and preventing lateral swaying. Finally, the medullary cavity of the mouse femur is precisely located and locked in place by a limiting puncture component for medullary cavity puncture and drug administration. This allows for real-time adjustment and fixation based on different femur sizes during puncture, and enables precise positioning and drug administration within the mouse's medullary cavity. This device achieves the effect of real-time adjustment and fixation based on different femur sizes during puncture, and precise positioning and drug administration within the mouse's medullary cavity.

[0014] Secondly, when preparing to administer medication to mice via medullary cavity puncture, the mice are first placed on the operating table with one side of the femoral medullary cavity positioned in the puncture fixation device. Then, based on the length of the mouse's femur, the electric push rod is controlled to move the sliding wheel on one side of the lifting plate up and down through the fixation frame, thereby causing the operating table to slide up and down. This makes the up-and-down sliding process of the operating table more stable, preventing shaking during the lifting process and affecting the subsequent positioning of the mouse's medullary cavity. At the same time, one end of the mouse's femur can be placed flat on the operating table, thus fixing the position of the mouse's femoral medullary cavity, limiting the height of the mouse's medullary cavity, and ensuring that the medullary cavity faces the output end of the limiting puncture component, guaranteeing that the position of the mouse's femoral medullary cavity will not slide up and down during medullary cavity puncture.

[0015] Thirdly, when it is necessary to perform medullary cavity puncture and drug administration on mice, the mouse femur must first be placed vertically between two arc-shaped clamping plates. By controlling the drive motor to work, the drive shaft is rotated clockwise, which in turn drives the drive gear to rotate clockwise. This causes the two drive racks located on the upper and lower sides of the drive gear and meshing with it to move synchronously closer to each other in the adjustment box. Then, the first drive rod and the second drive rod move closer to each other on the side of the two lifting plates that are far apart. This causes the two sliding shafts to slide relative to each other in the lifting plates. This causes the arc-shaped clamping plates to provide relative clamping force to the mouse femur, thereby fixing the position of the mouse femur so that it is perpendicular to the ground and does not wobble from side to side. Moreover, it can be adjusted in real time according to the different diameters of the mouse femur, so that the medullary cavity of the mouse femur is fixed between the two arc-shaped clamping plates for precise positioning.

[0016] Fourth, after fixing the mouse femur perpendicular to the ground, the medullary canal of the mouse femur is fixed between two arc-shaped clamping plates. By controlling the rotation of the fixing knob located on the side of the adjusting plate away from the slider, the adjusting rod moves forward or backward within the telescopic sleeve, thereby adjusting the slider located at one end of the adjusting rod to move forward or backward. The telescopic sleeve set in the sliding groove of the adjusting plate realizes the control of the left and right movement of the slider, thus making it easier to adjust the position of the slider so that its through-hole can be aligned with the mouse's medullary canal. Then, the limiting block on the fixing knob is locked in the limiting groove on the adjusting plate to realize the alignment of the slider. The block is fixed to better secure the puncture point. Finally, the needle insertion path of the puncture needle is restricted by the needle sleeve, thus preventing the puncture needle from coming out from the side, causing bone damage to the mouse, causing pain to the mouse, and leading to experimental failure. At the same time, the limiting block and the fixing knob are connected and fixed by a spring. When it is necessary to rotate the fixing knob to adjust the length of the adjusting rod or to slide the telescopic sleeve left and right, the limiting block can be retracted into the fixing knob by the spring, so as to facilitate the rotation and movement of the fixing knob. After the slider position is adjusted, the limiting block is then snapped into the limiting groove to fix the slider.

[0017] Fifth, after fixing the position of the mouse femur and aligning the through groove of the slider with the mouse's medullary cavity, the length of the mouse femur can be accurately measured using the scale perpendicular to the operating table on the fixation frame. This lays the foundation for the next step of medullary cavity puncture. By centering the scale parallel to the operating table on the slider with the 0 mark, the diameter of the mouse femur can be accurately calculated. This allows for more accurate positioning of the puncture point of the medullary cavity and the insertion length of the puncture needle, avoiding the possibility of experimental failure due to the puncture needle directly penetrating the mouse's medullary cavity. This makes the process of locating the mouse's medullary cavity more convenient and improves the efficiency of the experiment.

[0018] Sixth, when the fixed knob is rotated to control the adjustment rod to move forward or backward within the telescopic sleeve, the anti-slip texture on the surface of the fixed knob allows for better control of the adjustment precision during rotation, achieving fine control and further ensuring the accuracy of the medullary cavity puncture point. Attached Figure Description

[0019] The accompanying drawings, which are included to provide a further understanding of this application and form part of this application, illustrate exemplary embodiments and are used to explain this application, but do not constitute an undue limitation of this application. In the drawings:

[0020] Figure 1 This is a schematic diagram of the three-dimensional structure of this application. Figure 1 ;

[0021] Figure 2 This is a schematic diagram of the three-dimensional structure of this application. Figure 2 ;

[0022] Figure 3 This is a schematic diagram of the three-dimensional structure of this application. Figure 3 ;

[0023] Figure 4 This is a partial three-dimensional structural schematic diagram of this application;

[0024] Figure 5 This is a cross-sectional front view of the auxiliary fixing component in this application;

[0025] Figure 6 This is a three-dimensional structural diagram of the limiting puncture component in this application;

[0026] Figure 7 This is a partial three-dimensional structural diagram of the limiting puncture component in this application.

[0027] Figure Labels

[0028] Operating table 1, lifting plate 2, length measuring component 3, fixing frame 31, sliding wheel 32, electric push rod 33, puncture fixing device 4, auxiliary fixing component 41, adjusting box 411, drive gear 412, drive shaft 413, drive rack 414, first drive rod 415, second drive rod 416, sliding shaft 417, arc-shaped clamping plate 418, drive motor 419, limiting puncture component 42, adjusting plate 421, telescopic sleeve 422, adjusting rod 423, slider 424, needle sleeve 425, puncture needle 426, fixing knob 427. Detailed Implementation

[0029] To make the objectives, technical solutions, and advantages of this application clearer, the technical solutions of this application will be clearly and completely described below in conjunction with specific embodiments and corresponding drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0030] The technical solutions provided by the various embodiments of this application are described in detail below with reference to the accompanying drawings.

[0031] This application provides a mouse medullary cavity puncture fixation auxiliary positioning device, including an operating table 1, a lifting plate 2, a length measuring component 3, and a puncture fixation device 4. Two lifting plates 2 are provided, positioned on both sides of the operating table 1 with their bottoms connected to the top of the operating table 1. The puncture fixation device 4 is positioned between the two lifting plates 2 and located on one side of the operating table 1. The puncture fixation device 4 includes an auxiliary fixation component 41 and a limiting puncture component 42, both positioned between the two lifting plates 2. Length measuring components 3 for measuring femurs of different lengths are provided on both sides of the two lifting plates 2. When it is necessary to perform puncture and drug delivery into the mouse medullary cavity, the mouse is first placed on the operating table 1 with one side of the mouse's femoral medullary cavity positioned in the puncture fixation device 4. The height of the lifting plate 2 is adjusted according to the length of the mouse's femur using the length measuring component 3, thereby adjusting the operation... The height of platform 1 allows one end of the mouse femur to rest flat on the platform, thus fixing the height of the mouse femoral medullary cavity and aligning it with the output end of the limiting puncture component 42. This ensures that the position of the mouse femoral medullary cavity does not slide up and down during medullary cavity puncture. Then, based on the thickness of the mouse femur, the auxiliary fixation component 41 is used to laterally clamp the mouse femur, achieving lateral fixation and ensuring that the mouse femur is perpendicular to the ground for easy operation and to prevent lateral swaying. Finally, the limiting puncture component 42 precisely locates and locks the position of the mouse femoral medullary cavity for medullary cavity puncture and drug administration. This device achieves the effect of real-time adjustment and fixation according to different sizes of femurs during puncture, and precise positioning and drug administration of the mouse's medullary cavity.

[0032] Preferably, the length measuring component 3 includes a fixed frame 31, sliding wheels 32, and an electric push rod 33. Several sliding wheels 32 are provided, arranged symmetrically in pairs on opposite sides of the lifting plate 2 and fixedly connected thereto. Each sliding wheel 32 has a fixed frame 31 vertically mounted on its side, which slides vertically with the fixed frame. The electric push rod 33 is vertically mounted at the bottom of the operating table 1, and its output end is connected to the bottom of the operating table 1. When preparing to administer medication to a mouse via bone marrow aspiration, the mouse is first placed on the operating table 1, with one side of its femoral bone marrow cavity positioned in the aspiration fixation device. In position 4, based on the length of the mouse femur, the electric push rod 33 is controlled to work, thereby driving the sliding wheel 32 on one side of the lifting plate 2 to slide up and down through the fixing frame 31, thereby driving the operating table 1 to slide up and down, making the up and down sliding process of the operating table 1 more stable, and preventing shaking during the lifting process, which would affect the subsequent positioning of the mouse medullary cavity. At the same time, one end of the mouse femur can be placed flat on the operating table 1, thereby fixing the position of the mouse femoral medullary cavity, limiting the height of the mouse medullary cavity, and making the medullary cavity face the output end of the limiting puncture component 42, ensuring that the position of the mouse femoral medullary cavity will not slide up and down during medullary cavity puncture.

[0033] Preferably, the auxiliary fixing assembly 41 includes an adjustment box 411, a drive gear 412, a drive shaft 413, a drive rack 414, a first drive rod 415, a second drive rod 416, a sliding shaft 417, an arc-shaped clamping plate 418, and a drive motor 419. The adjustment box 411 is located at the bottom of one side of the operating table 1 and is fixedly connected to it. The drive shaft 413 is located inside the limiting box, and both ends of the drive shaft 413 are rotatably connected to the side ends of the adjustment box 411. Two drive racks 414 are provided, located on the upper and lower sides of the drive shaft 413 and connected to the inner wall of the limiting box. In a sliding fit, the drive gear 412 is mounted on and fixedly connected to the drive shaft 413. The toothed ends of the first drive rod 415 and the second drive rod 416 mesh with the drive gear 412. The first drive rod 415 and the second drive rod 416 are respectively mounted on the ends of the two drive racks 414 away from the drive gear 412. The tops of the first drive rod 415 and the second drive rod 416 are on the same horizontal line and are located on opposite sides of the two lifting plates 2. The tops of both the first drive rod 415 and the second drive rod 416 are horizontally mounted with sliding shafts 417 and fixedly connected to them. One end of each sliding shaft 417 passes through and slides with the lifting plate 2. An arc-shaped clamping plate 418 is provided at the adjacent ends of both sliding shafts 417. The two arc-shaped clamping plates are symmetrically arranged. The drive motor 419 is located outside the adjustment box 411, and its output end is connected to one end of the drive shaft 413. When bone marrow aspiration is required to administer medication to a mouse, the mouse femur is first placed vertically between the two arc-shaped clamping plates. By controlling the drive motor 419, the drive shaft 413 is rotated clockwise, which in turn rotates the drive gear 412 clockwise, thereby rotating the gear located on the drive shaft 413. The two drive racks 414 on the upper and lower sides of the moving gear 412 and meshing with it are synchronously brought closer to each other in the adjustment box 411. This drives the first drive rod 415 and the second drive rod 416 to move closer to each other on the opposite side of the two lifting plates 2. This, in turn, drives the two sliding shafts 417 to slide relative to each other in the lifting plate 2. This, in turn, drives the arc-shaped clamping plate to provide relative clamping force to the mouse femur, thereby fixing the position of the mouse femur so that it is perpendicular to the ground and does not wobble from side to side. It can also be adjusted in real time according to the different diameters of the mouse femur, so that the medullary cavity of the mouse femur is fixed between the two arc-shaped clamping plates for precise positioning.

[0034] Preferably, the limiting puncture assembly 42 includes an adjusting plate 421, a telescopic sleeve 422, an adjusting rod 423, a slider 424, a needle sleeve 425, a puncture needle 426, and a fixing knob 427. The adjusting plate 421 is disposed between two lifting plates 2 and located on one side of the operating table 1. Both ends of the adjusting plate 421 are fixedly connected to one of the lifting plates 2 respectively. The adjusting plate 421 has a groove for sliding the telescopic sleeve 422. The telescopic sleeve 422 is disposed in the groove. The telescopic rod is disposed in the telescopic sleeve 422 and threadedly connected to it. One end of the adjusting rod 423 is fixedly connected to the slider 424. The bottom of the slider 424 is higher than the height of the tube. At the top of the two arc-shaped clamps, the needle sleeve 425 is vertically mounted on the slider 424 with its output end facing downwards. The puncture needle 426 is located inside the needle sleeve 425. The slider 424 has a through-hole that matches the puncture needle 426. The fixing knob 427 is located on the side of the adjusting plate 421 away from the slider 424 and is fixedly connected to one end of the adjusting rod 423. The fixing knob 427 has several limiting blocks for fixing the sliding of the telescopic sleeve 422. The side of the adjusting plate 421 away from the slider 424 has several limiting grooves that fit the shape of the limiting blocks evenly. When the mouse femur is fixed and perpendicular to the ground, the bone marrow of the mouse femur... The cavity is fixed between two arc-shaped clamping plates. By controlling the rotation of the fixing knob 427 located on the side of the adjusting plate 421 away from the slider 424, the adjusting rod 423 moves forward or backward within the telescopic sleeve 422, thereby adjusting the slider 424 located at one end of the adjusting rod 423 to move forward or backward. The telescopic sleeve 422, located within the groove of the adjusting plate 421, controls the left and right movement of the slider 424, making it easier to adjust the position of the slider 424 so that its opening can be aligned with the mouse's bone marrow cavity. Then, the limiting block on the fixing knob 427 is engaged with the limiting groove on the adjusting plate 421, thus fixing the slider 424 and improving its stability. The puncture point is fixed, and the needle insertion path of the puncture needle 426 is restricted by the needle sleeve 425, thereby preventing the puncture needle 426 from piercing through the side, causing bone damage to the mouse, causing pain to the mouse, and leading to the failure of the experiment. At the same time, the limiting block and the fixing knob 427 are connected and fixed by a spring. When it is necessary to rotate the fixing knob 427 to adjust the length of the adjusting rod 423 or to slide the telescopic sleeve 422 left and right, the limiting block can be retracted into the fixing knob 427 by the spring, so as to facilitate the rotation and movement of the fixing knob 427. After the position of the slider 424 is adjusted, the limiting block is then snapped into the limiting groove to fix the slider 424.

[0035] Preferably, each of the fixing frames 31 has a scale perpendicular to the operating table 1 on the side away from the operating table 1, and the slider 424 has a scale parallel to the operating table 1 on the side away from the arc-shaped clamp, with the 0 mark of the scale located in the center. After the position of the mouse femur is fixed and the through groove of the slider 424 is aligned with the mouse's medullary cavity, the length of the mouse femur can be accurately measured by the scale perpendicular to the operating table 1 on the fixing frame 31, laying the foundation for the next step of medullary cavity puncture. By setting the 0 mark in the center of the scale parallel to the operating table 1 on the slider 424, the diameter of the mouse femur can be accurately calculated, thereby more accurately locating the puncture point of the medullary cavity and the insertion length of the puncture needle 426, avoiding the possibility of the puncture needle 426 directly penetrating the mouse's medullary cavity and causing experimental failure, making the process of locating the mouse's medullary cavity more convenient and improving the efficiency of the experiment.

[0036] Preferably, the surface of the fixed knob 427 is provided with anti-slip texture; when the fixed knob 427 is rotated to control the adjusting rod 423 to move forward or backward within the telescopic sleeve 422, the anti-slip texture on the surface of the fixed knob 427 allows for better control of the adjustment precision when controlling its rotation, achieving fine control and further ensuring the accuracy of the medullary cavity puncture point.

[0037] The above description is merely an embodiment of this application and is not intended to limit the scope of this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the scope of the claims of this application.

Claims

1. A mouse medullary cavity puncture fixation auxiliary positioning device, comprising an operating table (1), a lifting plate (2), a length measuring component (3), and a puncture fixation device (4), wherein there are two lifting plates (2), the two lifting plates (2) are arranged on both sides of the operating table (1) and the bottom of the lifting plates (2) is connected to the top of the operating table (1), the puncture fixation device (4) is arranged between the two lifting plates (2) and located on one side of the operating table (1), the puncture fixation device (4) includes an auxiliary fixation component (41) and a limiting puncture component (42), the auxiliary fixation component (41) and the limiting puncture component (42) are both arranged between the two lifting plates (2), and length measuring components (3) for measuring femurs of different lengths are provided on both sides of the two lifting plates (2). The length measuring component (3) includes a fixed frame (31), sliding wheels (32) and an electric push rod (33). There are several sliding wheels (32), and the several sliding wheels (32) are symmetrically arranged in pairs on the opposite side of the lifting plate (2) and fixedly connected to it. Each sliding wheel (32) has a fixed frame (31) vertical to the ground on its side end and slides up and down with it. The electric push rod (33) is vertically arranged at the bottom of the operating table (1), and the output end of the electric push rod (33) is connected to the bottom of the operating table (1). The auxiliary fixing assembly (41) includes an adjustment box (411), a drive gear (412), a drive shaft (413), a drive rack (414), a first drive rod (415), a second drive rod (416), a sliding shaft (417), an arc-shaped clamping plate (418), and a drive motor (419). The adjustment box (411) is located at the bottom of one side of the operating table (1) and is fixedly connected to it. The drive shaft (413) is located inside the limiting box, and both ends of the drive shaft (413) are rotatably connected to the side end of the adjustment box (411). There are two drive racks (414), which are located on the upper and lower sides of the drive shaft (413) and slide in cooperation with the inner wall of the limiting box. The drive gear (412) is located on the drive shaft (413) and is fixedly connected to it. The tooth groove ends of the first drive rod (415) and the second drive rod (416) are respectively... The first drive rod (415) and the second drive rod (416) are respectively located at the ends of the two drive racks (414) away from the drive gear (412). The tops of the first drive rod (415) and the second drive rod (416) are on the same horizontal line and are respectively located on the opposite side of the two lifting plates (2). The tops of the first drive rod (415) and the second drive rod (416) are each provided with a horizontally arranged sliding shaft (417) and fixedly connected to it. One end of each of the two sliding shafts (417) passes through the lifting plate (2) and slides with it. One end of each of the two sliding shafts (417) is provided with an arc-shaped clamping plate (418) at the adjacent end. The two arc-shaped clamping plates are symmetrically arranged. The drive motor (419) is located outside the adjustment box (411). The output end of the drive motor (419) is connected to one end of the drive shaft (413). The limiting puncture assembly (42) includes an adjusting plate (421), a telescopic sleeve (422), an adjusting rod (423), a slider (424), a needle sleeve (425), a puncture needle (426), and a fixing knob (427). The adjusting plate (421) has a groove for sliding the telescopic sleeve (422). The telescopic sleeve (422) is located in the groove. The adjusting rod (423) is located in the telescopic sleeve (422) and is threadedly connected to it. One end of the adjusting rod (423) is fixedly connected to the slider (424) to control the left and right movement of the slider (424), thereby facilitating the adjustment of the position of the slider (424) so ​​that its penetration opening can be aligned with the bone marrow cavity of the mouse.

2. The mouse bone marrow cavity puncture fixation and positioning auxiliary device according to claim 1, characterized in that, The adjusting plate (421) is located between the two lifting plates (2) and on one side of the operating table (1). The two ends of the adjusting plate (421) are fixedly connected to one of the lifting plates (2). The bottom of the slider (424) is higher than the top of the two arc-shaped clamps. The needle sleeve (425) is vertically set on the slider (424) with the output end facing downward. The puncture needle (426) is located inside the needle sleeve (425). The slider (424) is provided with a through hole that matches the puncture needle (426). The fixing knob (427) is located on the side of the adjusting plate (421) away from the slider (424) and is fixedly connected to one end of the adjusting rod (423). The fixing knob (427) is provided with several limiting blocks for fixing the sliding of the telescopic sleeve (422). The side of the adjusting plate (421) away from the slider (424) is uniformly provided with several limiting grooves that match the shape of the limiting blocks.

3. The mouse bone marrow cavity puncture fixation and positioning auxiliary device according to claim 2, characterized in that, Each of the fixed brackets (31) has a scale perpendicular to the operating table (1) on the side away from the operating table (1), and the slider (424) has a scale parallel to the operating table (1) on the side away from the arc fixture, with the 0 mark of the scale located in the middle.

4. The mouse bone marrow cavity puncture fixation and positioning auxiliary device according to claim 3, characterized in that, The surface of the fixed knob (427) is provided with anti-slip texture.

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