Slide imaging apparatus and method for imaging a slide

Abstract

The present disclosure relates to a slide imaging apparatus (110) and a method (210) for imaging a plurality of slides (140). The slide imaging apparatus (110) described herein comprises: - at least one imaging device (126, 128) configured to generate an image (162) of a sample mounted on a slide (140), wherein the imaging device (126, 128) comprises at least one operating button (160); - a storage device (118) loadable with a plurality of slides (140) and configured to store the slides (140); and - a supply device (120) configured to supply a slide (140) from the storage device (118) to the imaging device (126, 128), wherein the supply device (120) is configured to press the operating button (160). The slide imaging apparatus (110) and the method (210) for imaging a plurality of slides (140) enable to improve the handling of the slides to be processed in the imaging device, wherein the slides are provided to be introduced into a slide receiver of the imaging device.

Description

Technical Field

[0001] This disclosure relates to a slide imaging apparatus and a method for imaging multiple slides. The slide imaging apparatus described herein is preferably used in digital pathology; however, other applications are possible. Background Technology

[0002] Slide imaging devices include imaging apparatuses configured to generate images of samples mounted on slides. Images generated by modern imaging devices are typically digital images, hence the term "digital slide." Samples mounted on slides are usually biological specimens, such as tissue samples. Slides are typically glass slides. Slide imaging devices are commonly used in digital pathology, which can be understood as an image-based information environment capable of managing information generated from digital slides.

[0003] When an imaging device is capable (e.g., through a scanning process) of generating an image that covers most or all of the surface of a slide, the corresponding slide imaging apparatus may be referred to as a "whole slide imaging" apparatus. Slide imaging apparatuses may use a 2D (two-dimensional) camera or a line scan detector to generate images of samples mounted on a slide. Examples of slide imaging apparatuses include those described in EP 0 053 4247 B1, EP 0 245 089 A2, US 6 118 582 A, US 6 522 774 B1, US 6 640 014 B1, US 6 711 283 B1, US 7 682 573 B1, WO 2013 / 017855, US 8 712 116 B2, and US 9 116 035 B2.

[0004] Typically, imaging devices have the capacity to process 1 to 1000 slides simultaneously. Generally, imaging devices can be distinguished as having low throughput (processing fewer than 10 slides simultaneously) and high throughput (processing more than 100 slides simultaneously). Imaging devices configured to process 10 to 100 slides simultaneously can therefore be considered to have medium throughput. To charge an imaging device with one or more slides, individual slides are typically inserted manually into a slide bank (particularly a slide tray or slide holder), which is then introduced into the imaging device to generate the desired image of the sample mounted on the slide.

[0005] However, it is desirable to be able to insert slides into the slide receiver included in an imaging apparatus in an automated manner (particularly by using a suitable supply device). For this purpose, the supply device may be, or may include, a clamping device typically designed to perform specific clamping tasks. Regarding the disclosure herein, specific clamping tasks particularly include transferring slides in a tight manner to the slide receiver of the imaging apparatus, thereby avoiding slide instability or loss during transport.

[0006] Furthermore, when inserting a slide into the slide receiver of the imaging apparatus, the eject button of the imaging apparatus must simultaneously be pressed (specifically) to eject the slide tray, which is configured to hold the slide during slide scanning within the imaging apparatus. However, the robotic arm included in the supply device typically has only a limited space within which objects can be reached. Therefore, even when the gripping radius of the robotic arm is fully utilized, it may only be able to reach the slide receiver of the imaging apparatus and not the eject button.

[0007] WO 2019 / 097523 A1 discloses a microscope system including multiple microscope modules, a cassette for holding multiple slides, a slide loader configured to move multiple slides between the cassette and the multiple microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions that, when executed, cause the slide loader to move slides into or out of selected microscope modules among the multiple microscope modules. Various other methods, systems, and computer-readable media are also disclosed.

[0008] US 2018 / 252621 A1 discloses a method for removing floating liquid between a microscope slide and a paraffin-embedded biological specimen. The method involves placing a microscope slide with a paraffin-embedded biological specimen floating thereon on it onto a slide support element. The slide support element is rotated to move the microscope slide and the paraffin-embedded biological specimen, thereby removing the floating liquid between the microscope slide and the paraffin-embedded biological specimen.

[0009] Problems to be solved

[0010] Therefore, it is desirable to provide a slide imaging apparatus and a method for imaging multiple slides, which enables improved processing of slides to be processed in the imaging apparatus, wherein the slides are provided to be introduced into the slide receiver of the imaging apparatus.

[0011] In particular, it is desirable to be able to insert a slide into the slide receiver of the imaging device and simultaneously press the eject button of the imaging device (in particular) to eject the slide tray, which is configured to hold the slide during slide scanning in the imaging device. Summary of the Invention

[0012] The aforementioned problems are solved by a slide imaging apparatus having the features of the independent claims and a method for imaging multiple slides. Advantageous embodiments, which may be implemented in isolated manner or in any combination, are set forth in the dependent claims.

[0013] As used below, the terms “have,” “include,” or “contain,” or any grammatical variations thereof, are used in a non-exclusive manner. Thus, these terms can refer either to a situation where no other features exist in the entity described in this context besides those introduced by these terms, or to a situation where one or more additional features exist. For example, the statements “A has B,” “A contains B,” and “A includes B” can all refer to a situation where no other elements exist in A besides B (i.e., A is solely and uniquely composed of B), and to a situation where entity A contains one or more additional elements besides B, such as element C, elements C and D, or even further elements.

[0014] Furthermore, it should be noted that the terms "at least one," "one or more," or similar expressions indicating that a feature or element may exist once or more are generally used only once when the corresponding feature or element is introduced. In the following text, in most cases, when referring to the corresponding feature or element, the expressions "at least one" or "one or more" will not be used repeatedly, even though the corresponding feature or element may exist only once or more.

[0015] Furthermore, as used below, the terms "preferredly," "more preferably," "particularly," "more particularly," "specifically," "more specifically," or similar terms are used in combination with optional features without limiting the possibility of substitution. Therefore, features introduced by these terms are optional features and are not intended to limit the scope of the claims in any way. As those skilled in the art will recognize, the invention can be practiced by using alternative features. Similarly, features introduced by "in embodiments of the invention" or similar expressions are intended to be optional features, without limiting alternative embodiments of the invention, without limiting the scope of the invention, and without limiting the possibility of combining features introduced in this manner with other optional or non-optional features of the invention.

[0016] This document discloses and proposes a slide imaging device. As used herein, the term "slide" is a broad term and is given a common and conventional meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, a substrate used to mount samples on the surface of a slide. As used herein, the term "sample" is a broad term and is given a common and conventional meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, biological specimens, such as tissue samples. However, other types of samples may also be applicable.

[0017] Specifically, for the purpose of carrying samples without alteration during the handling of the slide, the substrate is mechanically stable and can therefore comprise any material that provides sufficient mechanical stability. Particularly for the purpose of carrying biological specimens, the substrate may preferably exhibit a surface configured to be compatible with biological materials. For example, glass slides are used because glass is known to provide sufficient mechanical stability on the one hand and high compatibility with biological materials on the other. However, many other types of slide materials are also feasible.

[0018] Furthermore, the slide may in particular have a form capable of imaging a sample mounted on it. As used herein, the terms “imaging” and “generating an image” are broad terms and are given common and customary meanings to those skilled in the art, and are not limited to specific or customary meanings. These terms may specifically refer to, but are not limited to, a 2D representation of at least one property of a sample, also referred to by the term “image,” which is generally processed and displayed on a screen for observation by a viewer’s eye, preferably without any further assistance other than the viewer’s glasses. For this purpose, imaging devices as disclosed in more detail above are generally used.

[0019] Furthermore, as used herein, the terms “apparatus” and “slide imaging apparatus” are broad terms and are given the common and customary meanings to those skilled in the art, and are not limited to specific or customary meanings. These terms may specifically refer to, but are not limited to, devices having the plurality of components disclosed in more detail below.

[0020] Specifically, slide imaging equipment includes:

[0021] – At least one imaging device configured to generate an image of a sample mounted on a glass slide, wherein the imaging device includes at least one operating button;

[0022] – A storage device that can be loaded with multiple glass slides and configured to store glass slides; and

[0023] – A supply device configured to supply a slide from a storage device to an imaging device, wherein the supply device is configured to press an operation button.

[0024] Accordingly, the slide imaging apparatus includes a storage device capable of loading and configuring multiple slides for storage. For the term "slide," refer to the definition provided above. As used herein, the term "storage device" is a broad term and will be given the common and customary meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, a slide storage library designated for receiving individual slide holders or, alternatively, simultaneously receiving more than one slide holder, wherein each slide holder is configured to hold more than one slide. In a preferred embodiment, the storage device may include at least two compartments, each of which is configured to store a portion of slides. The compartments herein may include at least two rows placed adjacent to each other, thus storing slides side-by-side. In particular, the storage device may be selected from a slide tray or slide rack; however, more types of storage devices are also feasible. However, more types of arrangements of slides and / or slide holders in the storage device are also feasible, respectively. Therefore, the storage device can preferably load multiple slides manually, although automatic loading of the storage device is also conceivable.

[0025] The slide imaging apparatus further includes a supply device configured to supply slides from a storage device to at least one imaging device. As used herein, the term "supply device" is a broad term and will be given a common and customary meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, a device configured to transfer slides from a storage device to at least one imaging device. For this purpose, the supply device may include a robotic arm. As used herein, the term "robotic arm" is a broad term and will be given a common and customary meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, a programmable mechanical unit having at least one of the forms of a hand or arm, and configured to move in a manner similar to a hand or arm using electrical and / or pneumatic actuation, including but not limited to gripping at least one object, particularly a slide or slide holder, and transferring it to a defined destination.

[0026] Therefore, this arrangement of the slide imaging apparatus disclosed herein is particularly the opposite of known slide imaging apparatuses, in which a single slide or slide holder, after loading one or more slides, is subsequently introduced into the imaging device to generate a desired image of a sample mounted on at least one slide. In the slide imaging apparatus disclosed herein, unlike known slide imaging apparatuses, multiple slides are loaded into a storage device, where the slides are stored until they are supplied from the storage device to at least one imaging device, where an image of the sample mounted on the slide is generated. The supply of slides from the storage device to at least one imaging device is preferably performed in an automated manner. As used herein, the terms “in an automated manner” and “automatically” are broad terms and are given common and customary meanings to those skilled in the art, and are not limited to specific or custom meanings. These terms may specifically refer to, but are not limited to, a process performed without direct user interaction of the slide imaging apparatus based on an algorithm configured to perform slide transfer without manual user intervention.

[0027] Typically, the supply device can be configured to process slides or slide holders along predetermined conventional routes, for example, starting from the top row of the storage device and continuing to the bottom row. In certain embodiments, the storage device may further include a fast lane. As used herein, the term "fast lane" is a broad term and is given a common and customary meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, a partition of the storage device configured to store at least one sample mounted onto a designated slide, wherein each designated slide is determined for priority processing outside of the conventional routes typically used by the supply device. Specifically designated slides can be further processed in this manner according to the specific expectations of the user of the slide imaging device.

[0028] In a further preferred embodiment, the supply device is configured to preferably transfer the slide from at least one imaging device back to the storage device after the scanning process is completed, specifically to an associated location within the storage device (where the slide has already been loaded). In other words, the supply device is configured to transfer the slide from the first or second imaging device back to the same location within the storage device (where the slide has already been loaded before being selectively transferred from the storage device to the first or second imaging device). Therefore, the user of the slide imaging device can receive the slides back in the same order they are supplied to the storage device, facilitating subsequent identification and possible further processing of the slides.

[0029] As described above, the slide imaging apparatus further includes at least one imaging device configured to generate an image of a sample mounted on a slide. As used herein, the term "imaging device" is a broad term and will be given the common and customary meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, a device designated for generating a 2D representation of at least one visual characteristic of a sample. In particular, the imaging device may be selected from a 2D camera or a line scan detector. However, other types of imaging devices are also feasible. Therefore, the slide imaging apparatus according to the invention may include one, two, three, four, five, six, or more individual imaging devices, wherein at least one individual imaging device can be individually processed by a supply device disclosed in more detail below. The additional imaging devices herein can be maintained as an additional backup option in the event of failure of more than one imaging device.

[0030] In order to generate the desired image of the sample, the slide may preferably be a plate with 2D extension and thickness, wherein the 2D extension of the plate may preferably be rectangular or circular, and wherein the thickness of the plate may be small compared to the size of the extension, preferably 20%, more preferably 10%, particularly 5%, or less than a measure of the linear range of the 2D extension of the plate.

[0031] Furthermore, at least one imaging device includes an operation button. As used herein, the term "operation button" is a broad term and is given a common and conventional meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, a component of a device, typically located on the surface of the device accessible to a person or object, and which can be pressed or released, wherein a message is sent to the device, and the device can then perform an operation. Thus, the terms "press (verb prototype)," "press (past participle)," or "press (present participle)" may specifically refer to, but is not limited to, a person or object striking a button, while the terms "release (verb prototype)," "release (past participle)," or "release (present participle)" may specifically refer to, but is not limited to, removing pressure from the button, each in a manner such that the position of the button relative to the surface of the device can withstand changes that may exceed a predefined threshold.

[0032] As disclosed herein, at least one operating button of an imaging device may preferably be or include a pop-up button. As used herein, the term "pop-up button" is a broad term and is given a common and customary meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, a particular type of button designed to provide an object to a user or object that presses the button, particularly a component of the device. Specifically with respect to this disclosure, the pop-up button is configured to pop out a slide tray when the pop-up button is pressed. As used herein, the term "slide tray" is a broad term and is given a common and customary meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, an element configured to hold at least one slide or slide holder, particularly during the scanning of at least one slide in an imaging device.

[0033] Accordingly, the supply device is configured to supply a slide from a storage device to at least one imaging device, wherein the supply device is configured to press an operation button. For this purpose, the supply device may preferably include a protrusion configured as a press-operation button. The protrusion described herein may specifically be spear-shaped or finger-shaped. However, many other types of shapes are also feasible.

[0034] Therefore, the operating button is subjected to impacts from the protrusion under various circumstances, which may cause wear on at least one of the protrusion or the operating button. Therefore, the supply device may include a protective cover configured to cover the protrusion. As used herein, the term "protective cover" is a broad term and is given a common and customary meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, a preferably flexible object that can be arranged to separate the component to be covered from the surrounding object. The shape of the protective cover herein may preferably be formed to cover the spear-shaped or finger-shaped protrusion in a particularly tight manner. Therefore, the protective cover can thus be configured to protect at least one of the protrusion and / or the operating button from wear.

[0035] As described above, the supply device may preferably include a robotic arm. As a result, protrusions may be arranged at the robotic arm, particularly by mounting protrusions to the robotic arm or by forming protrusions at the robotic arm. Specifically, the robotic arm may include gripping devices. As used herein, the term "gripping device" is a broad term and is given a common and customary meaning to those skilled in the art, and is not limited to a particular or customary meaning. The term may specifically refer to, but is not limited to, mechanical elements generally designed to grasp an object, transfer it to a desired location, and release the object at the desired location. With respect to the disclosure herein, a particular gripping device may therefore be configured to grip a slide or slide holder to transfer it in a tight manner to the slide receiver of the imaging device (thus avoiding instability or loss during transport) and release it, preferably to a slide tray as described elsewhere herein. The protrusions herein may be arranged at the gripping device so that the gripping device can insert the slide into the slide receiver of the imaging device and simultaneously press the eject button of the imaging device to eject the slide tray (configured to hold the slide during scanning in the imaging device). The clamping device described herein preferably includes a first clamping portion and a second clamping portion, wherein the first clamping portion and the second clamping portion are movable relative to each other, particularly in a linear manner. The first clamping portion and the second clamping portion may have surfaces facing each other, wherein these surfaces may be substantially planar, thereby supporting a tight clamping. However, further arrangements of protrusions are still conceivable.

[0036] Furthermore, the slide imaging apparatus may include at least one monitor configured to display at least one image, preferably multiple images, in a user-viewable demonstration of the slide imaging apparatus. In particular, the monitor may be mounted on a pivotable holder to allow the user to view at least one image from different positions.

[0037] Furthermore, the slide imaging apparatus may preferably include an operating system configured to control the operation of at least one component of the slide imaging apparatus, which may be selected in particular from at least one of the supply devices and at least one imaging device. For this purpose, the operating system may include at least one computer, at least one input device configured to input instructions to the computer, and at least one display device. The input device herein may preferably include a keyboard. Furthermore, the display device may preferably be configured to present to the user at least one information item related to the operating status of the slide imaging apparatus. However, further information may be provided.

[0038] Furthermore, the operating system can be aware of the operational status of at least one imaging device, which can be used to determine whether each imaging device is available. As used herein, the term "available" is a broad term and is given a common and customary meaning to those skilled in the art, and is not limited to a specific or customary meaning. The term may specifically refer to, but is not limited to, the operational status of a corresponding imaging device during preparation for scanning at least one slide. However, the operational status of an imaging device may further present an unavailable state, particularly during the warm-up phase or during a malfunction of the corresponding imaging device. For this purpose, a direct connection may be provided between the output of the imaging device and a computer capable of running an operating system. Alternatively or additionally, the slide imaging apparatus may further include at least one vision sensor configured to detect the operational status of at least one imaging device using at least one indicator, preferably configured in the form of one or more light-emitting diodes (LEDs) to indicate the corresponding operational status of the imaging device.

[0039] More preferred arrangements of the slide imaging apparatus are conceivable. Accordingly, the slide imaging apparatus may further include a frame (particularly a frame with wheels) and at least one plate connected to the frame, wherein at least one imaging device may be arranged on at least one plate. The at least one plate may extend from the frame independently of another plate, thus improving access for the service personnel to each imaging device. However, in embodiments where at least one imaging device may be considered too fragile to move, these plates may be optional. Preferably, two or more imaging devices may be arranged adjacent to each other, particularly one vertically above the other, or alternatively, horizontally adjacent to each other. Generally, the adjacent arrangement of at least two imaging devices facilitates access to a second imaging device by the robotic arm of the supply device. Furthermore, the slide imaging apparatus may include a table, to which at least a storage device and a supply device may be mounted. Additionally, the slide imaging apparatus may include a housing at least partially surrounding the supply device, wherein the housing may include a safety door and a safety switch configured to detect the status of the safety door. Furthermore, the slide imaging apparatus may include an emergency stop switch, and also includes an emergency stop button, wherein the emergency stop switch can be operated using the emergency stop button. Additional details regarding preferred arrangements of the slide imaging apparatus can be found in the embodiments disclosed below.

[0040] This paper further discloses and proposes a method for imaging multiple glass slides, wherein the method includes the following steps:

[0041] a) Load multiple glass slides into a storage device and store the glass slides in the storage device;

[0042] b) Using a supply device, a slide is supplied from the storage device to the imaging device, whereby the supply device simultaneously presses an operation button on the imaging device; and

[0043] c) Use an imaging device to generate an image of the sample mounted on a glass slide.

[0044] Specifically, the method can begin with step a), and then steps b) and c) can be repeated continuously for any or preferably all slides provided in step a). For this purpose, slides can be supplied automatically from a storage device to an imaging device to generate the desired sample image.

[0045] In addition, the following further steps d) can be performed:

[0046] d) Transfer the slide from the imaging device to the storage device.

[0047] As described above, the slide can be specifically conveyed to the relevant position within the storage device where the slide is already loaded. In other words, the slide can be conveyed to the same position within the storage device where it was loaded before being supplied from the storage device to at least one first imaging device or at least one second imaging device.

[0048] Further details regarding the methods for imaging multiple slides can be found in the slide imaging apparatus described elsewhere in this document.

[0049] This document further discloses and proposes a computer program including computer-executable instructions that, when executed on a computer or computer network, are used to perform the method according to the invention in one or more embodiments disclosed herein. Specifically, the computer program may be stored on a computer-readable data carrier and / or a computer-readable storage medium.

[0050] As used herein, the terms "computer-readable data carrier" and "computer-readable storage medium" specifically refer to non-transitory data storage devices, such as hardware storage media having computer-executable instructions stored thereon. Computer-readable data carriers or storage media may specifically be or may include storage media such as random access memory (RAM) and / or read-only memory (ROM).

[0051] Therefore, specifically, one, more, or even all of the method steps a) to d) as indicated above can be performed by using a computer or computer network, preferably by using a computer program.

[0052] This document further discloses and proposes a computer program product with program code tools so that, when executed on a computer or computer network, the method according to the invention is performed in one or more embodiments appended herein. Specifically, the program code tools may be stored on a computer-readable data carrier and / or a computer-readable storage medium.

[0053] This document further discloses and proposes a data bearer having a data structure stored thereon, which, after being loaded into a computer or computer network, such as after being loaded into the working memory or main memory of the computer or computer network, can perform methods according to one or more embodiments disclosed herein.

[0054] This document further discloses and proposes a computer program product having program code tools stored on a machine-readable carrier, so that when the program is executed on a computer or computer network, it performs methods according to one or more embodiments disclosed herein. As used herein, a computer program product refers to a program that is a tradable product. The product can generally exist in any format (such as paper format) or reside on a computer-readable data carrier and / or computer-readable storage medium. Specifically, the computer program product may be distributed on a data network.

[0055] This document further discloses and proposes a modulated data signal containing instructions readable by a computer system or computer network for performing a method according to one or more embodiments disclosed herein.

[0056] Referring to the computer implementation aspects of the present invention, one or more method steps, or even all method steps, of the methods according to one or more embodiments disclosed herein can be performed using a computer or computer network. Therefore, generally speaking, any method steps including providing and / or processing data can be performed using a computer or computer network. Generally, these method steps can include any method steps other than those typically requiring manual operation (such as providing specimens and / or performing certain aspects of actual measurements).

[0057] Specifically, this article further discloses the following:

[0058] - A computer or computer network including at least one processor, wherein the processor is adapted to perform a method according to one of the embodiments described in this specification.

[0059] - A computer-loadable data structure, which is adapted to perform a method according to one of the embodiments described in this specification when the data structure is executed on a computer.

[0060] - A computer program, wherein the computer program is adapted, when executed on a computer, to perform a method according to one of the embodiments described in this specification.

[0061] - A computer program, including program tools for performing, when executed on a computer or on a computer network, a method according to one of the embodiments described in this specification.

[0062] - A computer program comprising program means according to the foregoing embodiments, wherein the program means are stored on a computer-readable storage medium.

[0063] - A storage medium on which a data structure is stored and wherein the data structure is adapted to perform a method according to one of the embodiments described herein after being loaded into the main memory and / or working memory of a computer or computer network.

[0064] - A computer program product having program code tools, wherein the program code tools may be stored or stored on a storage medium for performing a method according to one of the embodiments described in this specification when the program code tools are executed on a computer or computer network.

[0065] Advantageously, slide imaging devices and methods for imaging multiple slides can improve the handling of slides to be processed in the imaging apparatus, wherein the slides are provided to be introduced into the slide receiver of the imaging apparatus. Specifically, they are capable of inserting the slide into the slide receiver of the imaging apparatus while simultaneously pressing an eject button (particularly) of the imaging apparatus to eject a slide tray configured to hold the slide or slide holder during scanning in the imaging apparatus.

[0066] In summary, and without excluding further possible embodiments, the following embodiments are conceivable:

[0067] Example 1. A slide imaging device, comprising:

[0068] - At least one imaging device configured to generate an image of a sample mounted on a glass slide, wherein the imaging device includes at least one operating button;

[0069] - A storage device that can be loaded with multiple glass slides and configured to store glass slides; and

[0070] - A supply device configured to supply a slide from a storage device to an imaging device, wherein the supply device is configured to press an operation button.

[0071] Example 2. The slide imaging apparatus according to Example 1, wherein the supply device includes a protrusion configured to press an operation button.

[0072] Example 3. The slide imaging device according to Example 2, wherein the protrusions are spear-shaped or finger-shaped.

[0073] Example 4. The slide imaging apparatus according to Example 2 or 3 further includes a protective cover configured to cover the protrusion.

[0074] Example 5. The slide imaging apparatus according to Example 4, wherein the protective cover is configured as at least one of a protective protrusion and an operating button.

[0075] Example 6. A slide imaging apparatus according to any one of Examples 1 to 5, wherein the supply device includes a robotic arm.

[0076] Example 7. The slide imaging device according to Example 6, wherein the protrusion is arranged at the robotic arm.

[0077] Example 8. The slide imaging device according to Example 7, wherein the protrusion is mounted or formed on the robotic arm.

[0078] Example 9. A slide imaging apparatus according to any one of Examples 6 to 8, wherein the robotic arm includes a clamping device configured to hold a slide or a slide holder.

[0079] Example 10. The slide imaging apparatus according to Example 9, wherein the protrusion is arranged at the clamping device.

[0080] Example 11. The slide imaging apparatus according to Example 9 or 10, wherein the clamping device includes a first clamping part and a second clamping part.

[0081] Example 12. The slide imaging apparatus according to Example 11, wherein the first clamping part and the second clamping part are movable relative to each other.

[0082] Example 13. The slide imaging apparatus according to Example 12, wherein the first clamping part and the second clamping part are linearly movable relative to each other.

[0083] Example 14. A slide imaging apparatus according to any one of embodiments 11 to 13, wherein the first clamping part and the second clamping part have surfaces facing each other.

[0084] Example 15. The slide imaging apparatus according to Example 14, wherein the surface is substantially planar.

[0085] Example 16. A slide imaging apparatus according to any one of Examples 1 to 15, wherein an operation button is located on the surface of the imaging device and can be easily pressed or released, thereby sending a message to the imaging device to perform the operation of the imaging device.

[0086] Example 17. The slide imaging device according to any one of Examples 1 to 16, wherein the operation button is a pop-up button or includes a pop-up button.

[0087] Example 18. The slide imaging apparatus according to Example 17, wherein the imaging device is configured to eject the slide tray when the eject button is pressed.

[0088] Example 19. A slide imaging apparatus according to any one of Examples 1 to 18, wherein the supply device is further configured to transfer a slide from at least one imaging device to a storage device.

[0089] Example 20. The slide imaging apparatus according to Example 19, wherein the supply device is configured to transfer a slide from at least one imaging device to a storage device to load the slide into a relevant position within the storage device.

[0090] Example 21. A slide imaging apparatus according to any one of Examples 1 to 20, wherein the storage device is capable of loading a slide holder, wherein the slide holder is configured to hold more than one slide.

[0091] Example 22. The slide imaging apparatus according to Example 21, wherein the storage device can manually load multiple slides or multiple slide holders.

[0092] Example 23. A slide imaging apparatus according to Example 21 or 22, wherein the storage device is configured to store slides or slide holders adjacent to each other.

[0093] Example 24. A slide imaging apparatus according to any one of Examples 21 to 23, wherein the storage device includes a rack configured to load slides or slide holders.

[0094] Example 25. A slide imaging apparatus according to any one of Examples 1 to 24, further comprising a fast channel configured to charge an imaging device having at least one sample mounted on a designated slide determined to be prioritized for processing.

[0095] Example 26. A slide imaging apparatus according to any one of Examples 1 to 25, wherein the imaging device is selected from a 2D camera or a line scan detector.

[0096] Example 27. A slide imaging apparatus according to any one of Examples 1 to 26, comprising at least two imaging devices.

[0097] Example 28. The slide imaging apparatus according to Example 27, wherein the supply device is configured to selectively supply slides from the storage device to one of at least two imaging devices.

[0098] Example 29. The slide imaging apparatus according to any one of Examples 1 to 28 further includes a frame (particularly a frame with wheels) and a stage.

[0099] Example 30. The slide imaging apparatus according to Example 29, wherein at least a storage device and a supply device are mounted on the worktable.

[0100] Example 31. The slide imaging apparatus according to any one of Examples 1 to 30, further comprising an operating system configured to control the operation of at least one of the supply device and the imaging device.

[0101] Example 32. The slide imaging apparatus according to Example 31, wherein the operating system includes at least one computer, at least one input device configured to input instructions to the computer, and at least one display device.

[0102] Example 33. The slide imaging apparatus according to Example 32, wherein the input device includes a keyboard.

[0103] Example 34. A slide imaging apparatus according to any one of Examples 1 to 33, further comprising at least one monitor configured to display an image of a sample mounted on a slide after being scanned by the imaging device.

[0104] Example 35. The slide imaging apparatus according to Example 34, wherein at least one monitor is mounted on a pivotable holder.

[0105] Example 36. The slide imaging apparatus according to any one of Examples 1 to 35, further comprising a housing that at least partially surrounds the supply device.

[0106] Example 37. The slide imaging apparatus according to Example 36, wherein the housing includes a safety door and a safety switch configured to detect the state of the safety door.

[0107] Example 38. The slide imaging apparatus according to any one of Examples 1 to 37, further comprising an emergency stop switch.

[0108] Example 39. The slide imaging device according to Example 38 further includes an emergency stop button.

[0109] Example 40. The slide imaging apparatus according to Example 39, wherein the emergency stop switch can be operated using an emergency stop button.

[0110] Example 41. A slide imaging apparatus according to any one of Examples 1 to 40, wherein the imaging device includes an indicator configured to indicate the operating state of the imaging device.

[0111] Example 42. The slide imaging apparatus according to Example 41, wherein the indicator includes at least one light-emitting diode (LED).

[0112] Example 43. The slide imaging apparatus according to Example 41 or 42, wherein the slide imaging apparatus further includes at least one visual sensor configured to detect the operating status of the imaging device using an indicator.

[0113] Example 44. A method for imaging multiple glass slides, comprising the following steps:

[0114] a) Load multiple glass slides into a storage device and store the glass slides in the storage device;

[0115] b) Using a supply device, a slide is supplied from the storage device to the imaging device, whereby the supply device simultaneously presses an operation button on the imaging device; and

[0116] c) Use an imaging device to generate an image of the sample mounted on a glass slide.

[0117] Example 45. The method according to Example 44, wherein the supply device includes a protrusion that presses the operation button.

[0118] Example 46. The method according to any one of Examples 44 or 45 further includes the following steps:

[0119] d) The slide is transferred from the imaging device to the storage device.

[0120] Example 47. The method according to Example 46, wherein the slide is conveyed to the relevant location within the storage device in which the slide has been loaded. Attached Figure Description

[0121] Further optional features and embodiments will be disclosed in more detail in the following description of the embodiments, preferably in conjunction with the dependent claims. As those skilled in the art will recognize, the various optional features may be implemented in an isolated manner and in any feasible combination. The scope of the invention is not limited to the preferred embodiments. Embodiments are schematically depicted in the accompanying drawings. In these drawings, the same reference numerals refer to the same or functionally comparable elements.

[0122] In the attached image:

[0123] Figure 1 schematically illustrates a preferred embodiment of the slide imaging apparatus according to the present disclosure in a side view; and

[0124] Figures 2A and 2B schematically illustrate a portion of a preferred embodiment of the supply device included in the slide imaging apparatus according to the present disclosure, in top view (Figure 2A) and side view (Figure 2B); and

[0125] Figure 3 schematically illustrates a preferred embodiment of a method for imaging multiple glass slides according to the present disclosure. Detailed Implementation

[0126] Figure 1 schematically illustrates a preferred embodiment of the slide imaging apparatus 110 according to the present disclosure in a side view. As shown in Figure 1, the slide imaging apparatus 110 may preferably include a frame 112, wherein the frame 112 may particularly include wheels 114, thereby enabling the slide imaging apparatus 110 to be moved to a desired location. As further depicted in Figure 1, the frame 112 further includes a table 116, wherein at least one storage device 118 and a supply device 120 are mounted on the table 116. However, other arrangements of the storage device 118 and the supply device 120 are also conceivable.

[0127] Further according to the embodiment shown in FIG1, the first plate 122 and the second plate 124 are connected to the frame 112, wherein the first imaging device 126 is arranged on the first plate 122, and the second imaging device 128 is arranged on the second plate 124. Further embodiments of the slide imaging apparatus 110 (not depicted herein) comprising only a single imaging device or three, four, five, six, or more individual imaging devices are also feasible, wherein at least one imaging device 126, 128 can be individually handled by the supply device 120, as disclosed in more detail below. Due to the specific arrangement shown in FIG1, the first imaging device 126 and the second imaging device 128 are arranged one on top of the other. However, more types of arrangements of the first imaging device 126 and the second imaging device 128 are also conceivable, particularly as long as they are accessible by the supply device 120. Furthermore, the first plate 122 and the second plate 124 may preferably extend from the frame 112, particularly by means of telescopic guides (not shown) extending independently, especially for ease of access in use. In this embodiment, precise positioning can preferably be achieved through recesses in plates 122 and 124, which are designed to receive the respective bases of imaging devices 126 and 128, respectively. However, other arrangements are also possible.

[0128] As further depicted in Figure 1, the slide imaging apparatus 110 according to this embodiment includes a housing 130 that at least partially surrounds the supply device 120, thus supporting undisturbed operation of the supply device 120. As schematically shown in Figure 1, the housing 130 has a safety door 132 and a safety switch 134, wherein the safety switch 134 is configured to detect the state of the safety door 132, such as whether the safety door 132 is open or closed. However, other types of safety provisions may also be possible.

[0129] Furthermore, the embodiment of the slide imaging apparatus 110 shown in Figure 1 includes an emergency stop switch 136, which can be operated using an emergency stop button 138. However, other types of emergency procedures are also possible. When the emergency stop button 138 is pressed, the emergency stop switch 136 can cause the operation of the slide imaging apparatus 110 to stop immediately if the service personnel deem it necessary.

[0130] As schematically shown in Figure 1, the storage device 118 can load and is configured to store multiple slides 140. Specifically, the multiple slides 140 can be manually loaded into the storage device 118. For this purpose, the storage device 118 can be loaded with at least one of individual slides and slide holders 142, wherein each slide holder 142 is configured to hold more than one slide 140. As further depicted in Figure 1, the storage device 118 is configured to store either the slides 140 or the slide holders 142 in rows 144 positioned adjacent to each other in an adjacent manner. However, further arrangements of the storage device 118 are also contemplated.

[0131] Typically, the supply device 120 may be configured to process slides 140 or slide holders 142 along predetermined conventional routes, for example, starting from the top row 146 of the storage device 118 and continuing to the bottom row 148. In a particular embodiment as depicted herein, the storage device 118 may include a fast channel 150, which may be configured to store at least one sample mounted on a designated slide 152, wherein each designated slide 152 is located in the fast channel 150, which is determined for priority processing outside of the conventional routes typically used by the supply device 120.

[0132] As further schematically shown in Figure 1, the supply device 120 may be configured to selectively supply slides 140 from the storage device 118 to the first imaging device 126 or the second imaging device 128. In a particularly preferred embodiment, the supply device 120 may be configured to automatically and selectively supply slides 140 from the storage device 120 to the first imaging device 126 or the second imaging device 128.

[0133] As schematically depicted, the supply device 120 may include a robotic arm 154, which may be specifically configured to introduce a slide 140 into a slide receiver 156, particularly a slit, as included in each of the first imaging device 126 and the second imaging device 128, wherein the slide receiver 156 is configured to receive the slide 140 for imaging purposes. As shown in more detail in Figure 3 below, the robotic arm 154 may include a gripping device 158 configured to grip either the slide 140 or the holder 142. More specifically, the gripping device 158 may have protrusions (not depicted here), particularly spear-shaped or finger-shaped protrusions, configured to press a first operating button 160 of the first imaging device 126 or the second imaging device 128. However, various other arrangements of the supply device 120 may still be possible.

[0134] Furthermore, the supply device 120 can be configured to transfer slides 140 from the first imaging device 126 or the second imaging device 128 after scanning the storage device 118. Thereafter, slides 140 can be manually removed from the storage device 118, thus providing space for more slides 140. Specifically, the supply device 120 can be configured to transfer slides 140 from the first imaging device 126 or the second imaging device 128 back to the storage device 118 to a relevant position within the storage device 118 where the slides 140 were previously loaded before scanning. Therefore, the user can receive the slides 140 back in the same order they were supplied to the storage device 118.

[0135] As described above, the exemplary slide imaging apparatus 110 shown in FIG1 includes a first imaging device 126 and a second imaging device 128, wherein each of the imaging devices 126, 128 is configured to generate an image 162 of a sample mounted on a slide 140. For this purpose, each of the imaging devices 126, 128 may preferably be selected from a 2D camera or a line scan detector. However, other types of imaging devices are also feasible.

[0136] In a particular embodiment, at least one of the first imaging device 126 and the second imaging device 128 may preferably include at least one indicator in the form of one or more LEDs 164, configured to indicate the operating status of the first imaging device 126 or the second imaging device 128, respectively. In this particular embodiment, as shown in FIG1, the slide imaging device 110 may further include at least one vision sensor 166 configured to detect the operating status of at least one of the first imaging device 126 and the second imaging device 128 using indications provided by the indicators (particularly by one or more LEDs 164). For this purpose, the vision sensor 166 may include an optical recording device 168 schematically depicted in FIG1. ​​In a further embodiment (not depicted here), the slide imaging device 110 may include at least two separate vision sensors 166, wherein each separate vision sensor 166 may include a separate optical recording device 168, wherein each separate optical recording device 168 may be assigned to detect the operating status of a separate imaging device 126, 128. However, further embodiments are still possible.

[0137] In this way, the slide imaging device 110 can independently access the operating status of the first imaging device 126 or the second imaging device 128, without needing to obtain this information directly from the first imaging device 126 and the second imaging device 128. However, it is also feasible to use direct communication between the first imaging device 126 or the second imaging device 128 (on one hand) and the operating system 170 (on the other hand) to provide the operating status of the first imaging device 126 and the second imaging device 128.

[0138] As described above, the slide imaging apparatus 110 may include an operating system 170 configured to control the operation of one or more of the supply device 120, the first imaging device 126, and the second imaging device 128. The operating system 170 may preferably include a computer 172 and an input device 174 configured to input instructions to the computer 170, wherein the input device 174 may include a keyboard 176 and at least one display device 178. The display device 178 may be used to display at least one information item related to the operating status of the slide imaging apparatus 110.

[0139] In addition, the slide imaging device 110 may include at least one monitor 180, which may preferably be mounted to a pivotable holder (not depicted here) to allow viewing of an image 162 of a sample mounted thereon after the slide 140 has been scanned by a user from different positions via the first imaging device 126 or via the second imaging device 128.

[0140] Figures 2A and 2B schematically illustrate a portion of a preferred embodiment of the supply device 120 included in the slide imaging apparatus 110. Figure 2A shows a top view, while Figure 2B shows a side view.

[0141] Accordingly, the robotic arm 154 included in the supply device 120 has a protrusion 182 disposed on the robotic arm 154. Typically, the protrusion 182 can be mounted to or formed on the robotic arm 154 in any conceivable manner. In the exemplary embodiment shown in Figures 2A and 2B, the robotic arm includes a gripping device 158 configured to grip a slide holder 142, as shown, wherein the slide holder 142 is configured to hold a plurality of slides 140, wherein the protrusion 182 is disposed on the gripping device 158. However, further arrangement of the protrusion 182 at the supply device 120 is feasible.

[0142] A protrusion 182 included in the supply device 120 (specifically the clamping device 158) is configured to press the operating button 160 of the imaging devices 126, 128. For this purpose, the protrusion 182 may preferably be spear-shaped or finger-shaped. The operating button 160 may be or include a pop-out button, wherein the imaging devices 126, 128 may be configured to pop out a slide tray (not depicted here) when the pop-out button is pressed. The slide tray herein may be configured to hold either the slide 140 or the slide holder 142 during scanning of at least one slide 140.

[0143] Therefore, the operating button 160 is subjected to impacts from the protrusion 182 under various conditions, which may cause wear on the protrusion 182 and / or the operating button 160. Therefore, as further shown in Figures 2A and 2B, a protective cover 184 may be provided, wherein the protective cover 184 may be configured to cover the protrusion 182, and wherein the shape of the protective cover 184 may preferably be formed to tightly cover the spear-shaped or finger-shaped protrusion 182. Thus, the protective cover 184 may be specifically configured to protect the protrusion 182 and / or the operating button 160.

[0144] As further shown in Figures 2A and 2B, the clamping device 158 may include a first clamping portion 186 and a second clamping portion 188, as indicated by arrow 190, wherein the first clamping portion 186 and the second clamping portion 188 may be movable relative to each other, particularly linearly relative to each other. Furthermore, the first clamping portion 186 and the second clamping portion 188 may have mutually facing surfaces 192, 194, wherein surfaces 192, 194 may preferably be substantially planar, and are thus employed on adjacent surfaces of the slide 140 or the slide holder 142, respectively. In this way, the clamping device 158 may be able to transfer the slide 140 or the slide holder 142 to the slide receiver 156 of the imaging apparatus 126, 128 in a tight manner, thereby preventing instability or loss of the slide 140 or the slide holder 142 during transport, respectively.

[0145] Figure 3 schematically illustrates a preferred embodiment of a method 210 for imaging multiple glass slides 140, wherein method 210 includes the following steps.

[0146] In loading step 212 according to step a), multiple slides 140 are loaded into and stored in storage device 118. The slides 140 herein may be loaded as individual slides 140 or by using a slide holder 142 configured to hold more than one slide 140.

[0147] In supply step 214 according to step b), slide 140 is supplied from storage device 118 to imaging devices 126, 128 using supply device 120. Preferably, slide 140 is supplied from storage device 118 to imaging devices 126, 128 automatically. Furthermore, supply device 120 simultaneously presses operation button 160 of imaging devices 126, 128, thereby ejecting a slide tray configured to hold either slide 140 or slide holder 142 during scanning of at least one slide 140.

[0148] In imaging step 216 according to step c), an image of the sample mounted on the slide 140 is generated using imaging devices 126 and 128. The image 162 can then be displayed on the monitor 180, as described above.

[0149] In the transfer step 218, the slide 140 may be transferred from the imaging apparatus 126, 128 to the storage device 118 as a single slide 140 or by using a slide holder 142 configured to hold more than one slide 140, in particular to the relevant location within the storage device 118 where the slide 140 or the slide holder has been respectively loaded.

[0150] Further details regarding the method 210 for imaging multiple slides 140 can be found in the slide imaging apparatus 110 described above.

[0151] List of reference numerals

[0152] 110 Slide Imaging Equipment

[0153] 112 Framework

[0154] 114 wheels

[0155] 116 Tables

[0156] 118 storage devices

[0157] 120 supply unit

[0158] 122 First board

[0159] 124 Second Board

[0160] 126 First Imaging Device

[0161] 128 Second Imaging Device

[0162] 130 casing

[0163] 132 Security Door

[0164] 134 Safety Switch

[0165] 136 Emergency Stop Switch

[0166] 138 Emergency Stop Button

[0167] 140 glass slides

[0168] 142 Slide Holder

[0169] Line 144

[0170] 146 Top row

[0171] 148 bottom row

[0172] 150 Fast Lane

[0173] 152 Specified glass slide

[0174] 154 robotic arms

[0175] 156 Slide Receiver

[0176] 158 Clamping Device

[0177] 160 Operation Buttons

[0178] 162 images

[0179] 164 Light Emitting Diode (LED),

[0180] 166 Vision Sensors

[0181] 168 Optical Recording Device

[0182] 170 Operating System

[0183] 172 Computers

[0184] 174 Input Device

[0185] 176 Keyboard

[0186] 178 Display

[0187] 180 monitor

[0188] 182 protrusions

[0189] 184 Protective Cover

[0190] 186 First clamping section

[0191] 188 Second clamping part

[0192] 190 arrow

[0193] 192 Surface

[0194] 194 Surface

[0195] 210 Methods for imaging glass slides

[0196] 212 Loading Steps

[0197] 214 Supply Steps

[0198] 216 Imaging Steps

[0199] 218 Transmission steps.

Claims

1. A slide imaging device (110), comprising: - At least one imaging device (126, 128) configured to generate an image (162) of a sample mounted on a glass slide (140), wherein, The imaging device (126, 128) includes at least one operation button (160). - A storage device (118) that can be loaded with a plurality of glass slides (140) and configured to store the glass slides (140). as well as - A supply device (120) configured to supply the slide (140) from the storage device (118) to the imaging device (126, 128), wherein the supply device (120) is configured to press the operation button (160), wherein the supply device (120) includes a protrusion (182) configured to press the operation button (160). The imaging devices (126, 128) are configured to eject a slide tray when the operation button is pressed.

2. The slide imaging device (110) according to claim 1, wherein, The protrusion (182) is spear-shaped or finger-shaped.

3. The slide imaging apparatus (110) according to claim 2, further comprising a protective cover (184) configured to cover the protrusion (182).

4. The slide imaging device (110) according to claim 3, wherein, The protective cover (184) is configured to protect at least one of the protrusion (182) and the operation button (160).

5. The slide imaging apparatus (110) according to any one of claims 1 to 4, wherein the supply device (120) includes a robotic arm (154).

6. The slide imaging device (110) according to claim 5, wherein, The protrusion (182) is located on the robotic arm (154).

7. The slide imaging device (110) according to claim 5, wherein, The robotic arm (154) includes a gripping device (158) configured to hold at least one of the slides (140) or a slide holder (142), the slide holder being configured to hold more than one slide (140).

8. The slide imaging device (110) according to claim 7, wherein, The protrusion (182) is located at the clamping device (158).

9. The slide imaging device (110) according to claim 7, wherein, The clamping device (158) includes a first clamping part (186) and a second clamping part (188), wherein the first clamping part (186) and the second clamping part (188) are movable relative to each other.

10. The slide imaging device (110) according to claim 8, wherein, The operation button (160) is a pop-up button, wherein the imaging devices (126, 128) are configured to pop up a slide tray when the pop-up button is pressed, wherein the clamping device (158) is configured to insert the slide (140) into the slide receiver of the imaging devices (126, 128) and simultaneously press the pop-up button of the imaging devices (126, 128) to pop up the slide tray.

11. The slide imaging device (110) according to claim 8, wherein, The operation button (160) includes a pop-up button, wherein the imaging devices (126, 128) are configured to pop up a slide tray when the pop-up button is pressed, wherein the clamping device (158) is configured to insert the slide (140) into the slide receiver of the imaging devices (126, 128) and simultaneously press the pop-up button of the imaging devices (126, 128) to pop up the slide tray.

12. The slide imaging apparatus (110) according to any one of claims 1 to 4, wherein, The operation button (160) is a pop-up button, wherein the imaging devices (126, 128) are configured to pop up a slide tray when the pop-up button is pressed.

13. The slide imaging apparatus (110) according to any one of claims 1 to 4, wherein, The operation button (160) includes a pop-up button, wherein the imaging device (126, 128) is configured to pop up a slide tray when the pop-up button is pressed.

14. The slide imaging apparatus (110) according to claim 10 or 11, wherein, The supply device (120) is configured to insert the slide (140) into the slide receiver of the imaging device (126, 128) and simultaneously press the eject button to eject the slide tray.

15. The slide imaging apparatus (110) according to any one of claims 1 to 4, wherein, The supply device (120) is further configured to transfer the slide (140) from the imaging device (126, 128) to the storage device (118).

16. The slide imaging apparatus (110) according to any one of claims 1 to 4, further comprising an operating system (170) configured to control the operation of at least one of the supply device (120) and the imaging device (126, 128).

17. The slide imaging apparatus (110) according to any one of claims 1 to 4, wherein, The supply device (120) is configured to simultaneously press the operation button (160) of the imaging device (126, 128).

18. The slide imaging apparatus (110) according to any one of claims 1 to 4, wherein, The supply device (120) is configured to press the operation button (160) of the imaging device (126, 128) while supplying the slide (140) from the storage device (118) to the imaging device (126, 128).

19. A method (210) for imaging multiple glass slides (140), comprising the following steps: a) Loading multiple glass slides (140) into a storage device (118) and storing the glass slides (140) in the storage device (118); b) Using the supply device (120), the slide (140) is supplied from the storage device (118) to the imaging device (126, 128), thereby pressing the operation button (160) of the imaging device (126, 128) simultaneously via the protrusion (182) of the supply device (120); and c) Using the imaging apparatus (126, 128), an image (162) of the sample mounted on the slide (140) is generated. The imaging devices (126, 128) are configured to eject a slide tray when the operation button is pressed.

Images