A three-ingredient hemorrhoid suppository for treating hemorrhoids

Abstract

Three kinds of hemorrhoids suppository for treating hemorrhoids, including traditional Chinese medicine raw material galls, white alum and borneol, the three kinds of hemorrhoids suppository including suppository shell made by water-soluble base and lidocaine hydrochloride, the water-soluble base is polyethylene glycol 6000 and polyethylene glycol 1500; the middle cavity in the suppository shell is sequentially filled with first suppository core made by semi-synthetic fatty acid glyceride and mixed traditional Chinese medicine raw material, glyceryl laurate and mixed traditional Chinese medicine raw material from front to back. The advantages are: the three kinds of hemorrhoids suppository adopts double-layer hemorrhoids suppository with water-soluble base as outer layer and water-soluble base as inner layer, the water-soluble base is outside, because the human body contains water, the water-soluble base suppository can be quickly dissolved in the human body, so that lidocaine hydrochloride drug acts on the local, the first suppository core and the second suppository core can have the effects of rapid release and slow release at the same time when used, avoiding the difficulty of drug release caused by mixing lidocaine hydrochloride and traditional Chinese medicine raw material, so as to accelerate the release of drug, and the treatment effect is good.

Description

TECHNICAL FIELD

[0001] The present application relates to a kind of three hemorrhoids suppository for treating hemorrhoids. BACKGROUND

[0002] "Three hemorrhoids suppository" according to the TCM theory of "acid can be astringent, dry can be fixed off", composed of five kinds of gallnut, white lead, camphor three Chinese medicines;Prescription five kinds of gallnut acid astringent cold, has the function of astringing and stopping bleeding, drying dampness and astringing sore, for hemorrhoids bleeding, swelling, has the effect of astringing and stopping bleeding, swelling and pain. The main component of white lead is potassium aluminum sulfate, this component can make hemorrhoids pathological part form foreign body collagen fibrosis, so that local tissue hardening atrophy, so as to make local swelling and pain. Camphor tastes bitter and aromatic, runs through, bitter and cold and clears heat and relieves pain, has antibacterial analgesic effect, and local has cool feeling, achieves the effect of anti-inflammatory analgesia. Three hemorrhoids suppository has the effect of astringing and stopping bleeding, swelling and pain, drying dampness and relieving itching. Preclinical pharmacological test shows that three hemorrhoids suppository can inhibit the inflammatory response of mice caused by dimethylbenzene and rats caused by carrageenan;It has analgesic and antipruritic effects, can inhibit the pain response of rats caused by heat radiation;Shorten the bleeding time of tail-cutting mice;Increase the itching threshold of damaged skin in rats caused by histamine.

[0003] Hemorrhoids are flexible lumps formed by the expansion and flexion of subcutaneous venous plexus of anal canal and mucous membrane at the end of rectum, and severe complex hemorrhoids refers to severe symptoms, long course, strong clinical symptoms and serious conditions. When the disease occurs, it brings great pain to patients. At present, the market mainly uses hemorrhoids suppository and hemorrhoids ointment to treat hemorrhoids, and when using, it is directly applied to the affected area. However, when severe hemorrhoids occurs, ulcer surface and / or wound surface are formed on the affected area, and direct application of the drug to the affected area causes strong irritation to the affected area, aggravates the pain of the affected area, and makes the patient have a certain psychological burden on the drug. SUMMARY

[0004] The purpose of the present application is to provide a kind of three hemorrhoids suppository for treating hemorrhoids, which is composed of five kinds of gallnut, white lead and camphor, to avoid ulcer surface and / or wound surface irritation, reduce the pain of severe patients, and has strong drug penetration, drug diffusion speed, fast effect and ideal drug effect.

[0005] A kind of three hemorrhoids suppository for treating hemorrhoids, including traditional Chinese medicine raw material five kinds of gallnut, white lead and camphor, characterized by: the three hemorrhoids suppository includes a water-soluble matrix and hydrochloric acid lidocaine to make a suppository shell, the mass ratio of the total amount of traditional Chinese medicine raw material and hydrochloric acid lidocaine is (7.5-15):115;The middle cavity in the suppository shell is filled with a first suppository core made of a fatty matrix semi-synthetic fatty acid glyceride and mixed traditional Chinese medicine raw material, a second suppository core made of a fatty matrix glycerol trilaurate and mixed traditional Chinese medicine raw material from front to back;

[0006] The water-soluble base is polyethylene glycol 6000 and polyethylene glycol 1500 with a mass ratio of 1:0.7, and the mass ratio of the mixed traditional Chinese medicine raw materials to the semi-synthetic fatty acid glyceride in the first plug core is 1:1.07-1:1.1, and the mass ratio of the mixed traditional Chinese medicine raw materials to glyceryl trilaurate in the second plug core is 1:1.06-1:1.1.

[0007] Further preferably, the mass ratio of the water-soluble base for the plug shell to the fatty base for the first plug core and the second plug core is 1:1.

[0008] Further preferably, the mass ratio of the raw materials in the first plug core to the raw materials in the second plug core is 1:0.5-1:2.

[0009] Further preferably, the water-soluble base is polyethylene glycol 6000 and polyethylene glycol 1500.

[0010] Further preferably, the mass ratio of the polyethylene glycol 6000 to the polyethylene glycol 1500 is 1:0.7.

[0011] Further preferably, the mass ratio of the gallnut, alum and menthol is 80:25:10.

[0012] In another aspect, a preparation method of the three-ingredient hemorrhoid suppository for treating hemorrhoids is provided, and the specific preparation process is as follows:

[0013] (1) Preparation of lidocaine hydrochloride suppository shell

[0014] The water-soluble base is heated and melted, and lidocaine hydrochloride is added. The temperature is kept at 40-50°C. A steel pipe is inserted into the middle part of the suppository mold to fix it. The mixture of the water-soluble base and lidocaine hydrochloride is injected between the suppository mold and the steel pipe. After cooling and solidification, the steel pipe is pulled out, and the plug core is poured into the cavity.

[0015] (2) Pouring of the plug core

[0016] First, the semi-synthetic fatty acid glyceride fatty base is heated and melted, and part of the mixed traditional Chinese medicine raw materials is added. The first plug core is formed by quantitative injection into the hollow part of the suppository shell. Then, the glyceryl trilaurate fatty base is heated and melted, and the remaining mixed traditional Chinese medicine raw materials is added. The second plug core is formed by further quantitative injection into the hollow part of the suppository shell. After cooling, the suppository is taken out of the mold and packaged to obtain the three-ingredient hemorrhoid suppository.

[0017] The beneficial effects of the present application are as follows:

[0018] (1) The double-layer hemorrhoid suppository with water-soluble matrix as the outer layer and water-soluble matrix as the inner layer, the water-soluble matrix is outside, because the human body contains water, the water-soluble suppository can be quickly dissolved into the human body, so that the lidocaine hydrochloride drug acts on the local part, reduces the ulcer surface and / or wound surface stimulation of the severe hemorrhoid affected part, and reduces the suffering of severe patients, and the drug has strong penetration, the drug diffusion speed, the diffusion range is wide, and the effect is fast.

[0019] (2) Compared with procaine, tetracaine, bupivacaine and cinchocaine, lidocaine hydrochloride has good permeability, fast onset speed, good drug time effect, low toxicity, and does not remain in the body for a long time, and has ideal drug effect and good treatment effect for the anal swelling and pain in hemorrhoids.

[0020] (3) The three-ingredient hemorrhoid suppository has the effects of rapid release and sustained release at the same time when used, avoids the difficulty of drug release caused by mixing lidocaine hydrochloride with traditional Chinese medicine raw materials, and accelerates the release of the drug. The suppository is convenient to use, has significant treatment effect, can treat or relieve internal hemorrhoids, external hemorrhoids (inflammatory external hemorrhoids, thrombotic external hemorrhoids, varicose external hemorrhoids), mixed hemorrhoids and anal bleeding, anal itching, constipation, anal swelling and pain, hemorrhoid nucleus shedding and other symptoms caused by them. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 is a schematic diagram of the three-ingredient hemorrhoid suppository of the present application. DETAILED DESCRIPTION

[0022] Example 1

[0023] The three-ingredient hemorrhoid suppository for treating hemorrhoids comprises a suppository shell made of water-soluble matrix and lidocaine hydrochloride; the middle cavity in the suppository shell is sequentially filled from front to back with a first suppository core made of semi-synthetic fatty acid glyceride and mixed traditional Chinese medicine raw materials, and a second suppository core made of glycerol trilaurate and mixed traditional Chinese medicine raw materials; this embodiment takes the preparation of 250 three-ingredient hemorrhoid suppositories as an example, and the specific preparation method is as follows:

[0024] (1) Weigh the traditional Chinese medicine raw materials

[0025] Weigh 80g of gallnut, 25g of white alum and 10g of borneol, mix uniformly to obtain the mixed raw materials;

[0026] (2) Preparation of lidocaine hydrochloride suppository shell

[0027] Take 74.26g of polyethylene glycol 6000 and 51.99g of polyethylene glycol 1500 water-soluble matrix and heat to melt, add 7.5g of lidocaine hydrochloride, constant temperature 50℃, insert a steel pipe into the middle part of the bullet-shaped suppository mold, inject the mixture of water-soluble matrix and lidocaine hydrochloride between the bullet-shaped suppository mold and the steel pipe, wait for cooling and solidification, then pull out the steel pipe, and pour the suppository core into the cavity.

[0028] (3) Filling the plug core

[0029] First, 63.125 g of semi-synthetic fatty acid glyceride base is heated and melted, 57.5 g of mixed traditional Chinese medicine raw materials is added, and the mixture is quantitatively injected into the hollow part of the plug shell to form a first plug core. Then, 63.125 g of glyceryl laurate base is heated and melted, 57.5 g of mixed traditional Chinese medicine raw materials is added, and the mixture is continuously quantitatively injected into the hollow part of the plug shell to form a second plug core. After cooling, the three-ingredient hemorrhoid suppository (plug weight 1.5 g) is obtained. Usage: externally used, wash the affected area, wear a sterile finger cot, and put the drug suppository into the anus with hands, one at a time, twice a day, and seven days as a course of treatment.

[0030] Example 2

[0031] The three-ingredient hemorrhoid suppository for treating hemorrhoids comprises a plug shell made of water-soluble base and lidocaine hydrochloride. The middle cavity in the plug shell is sequentially filled with a first plug core made of semi-synthetic fatty acid glyceride and mixed traditional Chinese medicine raw materials, and a second plug core made of glyceryl laurate and mixed traditional Chinese medicine raw materials. This example takes the preparation of 250 three-ingredient hemorrhoid suppositories as an example, and the specific preparation method is as follows:

[0032] (1) Weighing traditional Chinese medicine raw materials

[0033] Weigh 80 g of gallnut, 25 g of white alum, and 10 g of borneol, and mix them evenly to obtain mixed raw materials.

[0034] (2) Preparing lidocaine hydrochloride plug shell

[0035] Take 72.06 g of polyethylene glycol 6000 and 50.44 g of polyethylene glycol 1500 water-soluble base and heat and melt them, add 15 g of lidocaine hydrochloride, keep the temperature at 40°C, insert a steel pipe into the middle part of the bullet-shaped suppository mold, inject the mixture of water-soluble base and lidocaine hydrochloride between the bullet-shaped suppository mold and the steel pipe, and after cooling and solidification, pull out the steel pipe and fill the plug core in the cavity.

[0036] (3) Filling the plug core

[0037] First, 40.83 g of semi-synthetic fatty acid glyceride base is heated and melted, 38 g of mixed traditional Chinese medicine raw materials is added, and the mixture is quantitatively injected into the hollow part of the plug shell to form a first plug core. Then, 81.67 g of glyceryl laurate base is heated and melted, 77 g of mixed traditional Chinese medicine raw materials is added, and the mixture is continuously quantitatively injected into the hollow part of the plug shell to form a second plug core. After cooling, the three-ingredient hemorrhoid suppository (plug weight 1.5 g) is obtained. Usage: externally used, wash the affected area, wear a sterile finger cot, and put the drug suppository into the anus with hands, one at a time, twice a day, and seven days as a course of treatment.

[0038] Example 3

[0039] The three-ingredient hemorrhoid suppository for treating hemorrhoids comprises a suppository shell made of a water-soluble base and lidocaine hydrochloride; the middle cavity in the suppository shell is sequentially filled from front to back with a first suppository core made of semi-synthetic fatty acid glyceride and mixed traditional Chinese medicine raw materials, and a second suppository core made of glyceryl laurate and mixed traditional Chinese medicine raw materials; this embodiment takes the preparation of 250 three-ingredient hemorrhoid suppositories as an example, and the specific preparation method is as follows:

[0040] (1) Weigh traditional Chinese medicine raw materials

[0041] Weigh 80g of gallnut, 25g of white alum and 10g of borneol, mix them evenly, and obtain mixed raw materials;

[0042] (2) Preparation of lidocaine hydrochloride suppository shell

[0043] Take 73.53g of polyethylene glycol 6000 and 51.47g of polyethylene glycol 1500 water-soluble base and heat them to melt, add 10g of lidocaine hydrochloride, keep the temperature at 45℃, insert a steel pipe into the middle part of the bullet-shaped suppository mold, inject the mixture of water-soluble base and lidocaine hydrochloride between the bullet-shaped suppository mold and the steel pipe, wait for it to cool and solidify, then pull out the steel pipe, and pour the suppository core into the cavity;

[0044] (3) Pouring of the suppository core

[0045] First, heat 83.33g of semi-synthetic fatty acid glyceride base to melt, add 77g of mixed traditional Chinese medicine raw materials, and quantitatively inject them into the hollow part of the suppository shell to form the first suppository core; then, heat 41.67g of glyceryl laurate base to melt, add 38g of mixed traditional Chinese medicine raw materials, and continue to quantitatively inject them into the hollow part of the suppository shell to form the second suppository core, cool, package, and obtain the three-ingredient hemorrhoid suppository (suppository weight 1.5g). Usage: external use, wash the affected area, put on sterile gloves, and put the suppository into the anus with your hand, one at a time, twice a day, and seven days as a course of treatment.

[0046] Selection of drugs in the suppository shell:

[0047] Replace the drug lidocaine hydrochloride in the suppository shell with other drugs such as procaine, tetracaine, bupivacaine, and cinchocaine, and the rest is the same as in Example 1, as follows:

[0048] Comparative Example 1

[0049] The three-ingredient hemorrhoid suppository for treating hemorrhoids comprises a suppository shell made of a water-soluble base and procaine; the middle cavity in the suppository shell is sequentially filled from front to back with a first suppository core made of semi-synthetic fatty acid glyceride and mixed traditional Chinese medicine raw materials, and a second suppository core made of glyceryl laurate and mixed traditional Chinese medicine raw materials; this embodiment takes the preparation of 250 three-ingredient hemorrhoid suppositories as an example, and the specific preparation method is as follows:

[0050] (1) Weighing Chinese medicine raw materials

[0051] Weighing Chinese medicine raw materials gallnut 80g, white lead 25g and borneol 10g, mixing evenly, obtaining mixed raw materials;

[0052] (2) Preparing procaine suppository shell

[0053] Taking 74.26g polyethylene glycol 6000 and 51.99g polyethylene glycol 1500 water-soluble matrix, heating and melting, adding 7.5g procaine, constant temperature 50℃, inserting steel pipe into the middle part of bullet-shaped suppository mold, injecting water-soluble matrix and procaine mixture between bullet-shaped suppository mold and steel pipe, after cooling and solidification, pulling out steel pipe, filling the cavity with the core;

[0054] (3) Filling the core

[0055] First, heating and melting 63.125g semi-synthetic fatty acid glyceride matrix, adding 57.5g mixed Chinese medicine raw materials, quantitatively injecting into the hollow part of the shell, forming the first core; then, heating and melting 63.125g glyceryl laurate matrix, adding 57.5g mixed Chinese medicine raw materials, continuing to quantitatively inject into the hollow part of the shell, forming the second core, cooling, packaging, obtaining three kinds of hemorrhoid suppository (suppository weight 1.5g). Usage: external use, wash the affected part, wear sterile gloves and put the medicine suppository into the anus with your hand, one at a time, twice a day, seven days as a course of treatment.

[0056] Comparative Example 2

[0057] The three kinds of hemorrhoid suppository for treating hemorrhoids includes a suppository shell made of water-soluble matrix and tetracaine; the middle cavity in the suppository shell is sequentially filled from front to back with a first core made of semi-synthetic fatty acid glyceride and mixed Chinese medicine raw materials, and a second core made of glyceryl laurate and mixed Chinese medicine raw materials; this example takes preparing 250 three kinds of hemorrhoid suppositories as an example, and the specific preparation method is as follows:

[0058] (1) Weighing Chinese medicine raw materials

[0059] Weighing Chinese medicine raw materials gallnut 80g, white lead 25g and borneol 10g, mixing evenly, obtaining mixed raw materials;

[0060] (2) Preparing tetracaine suppository shell

[0061] Taking 74.26g polyethylene glycol 6000 and 51.99g polyethylene glycol 1500 water-soluble matrix, heating and melting, adding 7.5g tetracaine, constant temperature 50℃, inserting steel pipe into the middle part of bullet-shaped suppository mold, injecting water-soluble matrix and tetracaine mixture between bullet-shaped suppository mold and steel pipe, after cooling and solidification, pulling out steel pipe, filling the cavity with the core;

[0062] (3) Filling the plug core

[0063] First, 63.125 g of semi-synthetic fatty acid glyceride base is heated and melted, 57.5 g of mixed traditional Chinese medicine raw materials is added, and the first plug core is formed by quantitative injection into the hollow part of the plug shell. Then, 63.125 g of glyceryl laurate base is heated and melted, 57.5 g of mixed traditional Chinese medicine raw materials is added, and the second plug core is formed by quantitative injection into the hollow part of the plug shell. After cooling and packaging, the three-ingredient hemorrhoid suppository (suppository weight 1.5 g) is obtained. Usage: externally used, wash the affected area, wear a sterile finger cot, and put the drug suppository into the anus with your hand, one at a time, twice a day, and seven days as a course of treatment.

[0064] Comparative Example 3

[0065] The three-ingredient hemorrhoid suppository for treating hemorrhoids comprises a plug shell made of a water-soluble base and bupivacaine; the middle cavity in the plug shell is sequentially filled with a first plug core made of semi-synthetic fatty acid glyceride and mixed traditional Chinese medicine raw materials, and a second plug core made of glyceryl laurate and mixed traditional Chinese medicine raw materials. This example takes the preparation of 250 three-ingredient hemorrhoid suppositories as an example, and the specific preparation method is as follows:

[0066] (1) Weighing traditional Chinese medicine raw materials

[0067] Weigh 80 g of gallnut, 25 g of white alum, and 10 g of borneol, mix them evenly, and obtain the mixed raw materials;

[0068] (2) Preparing bupivacaine plug shell

[0069] Take 74.26 g of polyethylene glycol 6000 and 51.99 g of polyethylene glycol 1500 water-soluble base and heat and melt, add 7.5 g of bupivacaine, keep the temperature at 50°C, insert a steel pipe into the middle part of the bullet-shaped suppository mold, inject the mixture of water-soluble base and bupivacaine between the bullet-shaped suppository mold and the steel pipe, and after cooling and solidification, pull out the steel pipe and fill the plug core in the cavity;

[0070] (3) Filling the plug core

[0071] First, 63.125 g of semi-synthetic fatty acid glyceride base is heated and melted, 57.5 g of mixed traditional Chinese medicine raw materials is added, and the first plug core is formed by quantitative injection into the hollow part of the plug shell. Then, 63.125 g of glyceryl laurate base is heated and melted, 57.5 g of mixed traditional Chinese medicine raw materials is added, and the second plug core is formed by quantitative injection into the hollow part of the plug shell. After cooling and packaging, the three-ingredient hemorrhoid suppository (suppository weight 1.5 g) is obtained. Usage: externally used, wash the affected area, wear a sterile finger cot, and put the drug suppository into the anus with your hand, one at a time, twice a day, and seven days as a course of treatment.

[0072] Comparative Example 4

[0073] The three-ingredient hemorrhoid suppository for treating hemorrhoids comprises a suppository shell made of a water-soluble base and xylocaine; an intermediate cavity in the suppository shell is sequentially filled with a first suppository core made of a semi-synthetic fatty acid glyceride and mixed traditional Chinese medicine raw materials, and a second suppository core made of glyceryl laurate and mixed traditional Chinese medicine raw materials; the specific preparation method is as follows by taking preparation of 250 three-ingredient hemorrhoid suppositories as an example:

[0074] (1) weigh traditional Chinese medicine raw materials

[0075] The mixed raw materials are obtained by weighing 80 g of gallnut, 25 g of white alum and 10 g of borneol, and mixing them uniformly;

[0076] (2) preparation of xylocaine suppository shell

[0077] 74.26 g of polyethylene glycol 6000 and 51.99 g of polyethylene glycol 1500 water-soluble base are heated and melted, 7.5 g of xylocaine is added, the temperature is kept at 50°C, a steel pipe is inserted into the middle part of the bullet-shaped suppository mold, the water-soluble base and xylocaine mixture is injected between the bullet-shaped suppository mold and the steel pipe, after cooling and solidification, the steel pipe is pulled out, and the suppository core is poured into the cavity;

[0078] (3) pouring of the suppository core

[0079] First, 63.125 g of semi-synthetic fatty acid glyceride base is heated and melted, 57.5 g of mixed traditional Chinese medicine raw materials is added, and the first suppository core is formed by quantitative injection into the hollow part of the suppository shell; then, 63.125 g of glyceryl laurate base is heated and melted, 57.5 g of mixed traditional Chinese medicine raw materials is added, and the second suppository core is formed by further quantitative injection into the hollow part of the suppository shell, cooling, packaging, and obtaining the three-ingredient hemorrhoid suppository (suppository weight 1.5 g). The use method is as follows: external use, wash the affected part, wear sterile gloves, put the medicine suppository into the anus with hands, one at a time, twice a day, and seven days as a course of treatment.

[0080] The pharmacological effects of Example 1 and Comparative Examples 1-4 of the present application are shown in Table 1.

[0081] Table 1

[0082]

[0083] In the suppository shell used in Example 1 and Comparative Examples 1-4, lidocaine hydrochloride is used in the suppository, which has good permeability. As can be seen from Table 1, it has fast onset speed, good drug time effect, small toxicity, and does not remain in the body for a long time, and has ideal drug effect and good treatment effect for the symptom of anal swelling and pain in hemorrhoids.

Claims

1. A three-ingredient hemorrhoid suppository for treating hemorrhoids, comprising traditional Chinese medicinal raw materials of gallnut, white alum and borneol, characterized in that: The three-ingredient hemorrhoid suppository comprises a suppository shell made of a water-soluble base and lidocaine hydrochloride, the mass ratio of the lidocaine hydrochloride to the total amount of the traditional Chinese medicine raw materials being (7.5-15):115; the middle cavity in the suppository shell is sequentially filled with a first suppository core made of a fatty base semi-synthetic fatty acid glyceride and mixed traditional Chinese medicine raw materials, and a second suppository core made of a fatty base glycerol trilaurate and mixed traditional Chinese medicine raw materials; and the mass ratio of the mixed traditional Chinese medicine raw materials to the semi-synthetic fatty acid glyceride in the first suppository core is 1:1.07-1:1.1, and the mass ratio of the mixed traditional Chinese medicine raw materials to the glycerol trilaurate in the second suppository core is 1:1.06-1:1.1; the water-soluble base is polyethylene glycol 6000 and polyethylene glycol 1500, and the mass ratio of the polyethylene glycol 6000 to the polyethylene glycol 1500 is 1:0.

7. ​ 2. The three-ingredient hemorrhoid suppository for treating hemorrhoids according to claim 1, characterized by: The mass ratio of the water-soluble base for the suppository shell to the fatty base for the first and second suppository cores is 1:

1.

3. The three-ingredient hemorrhoid suppository for treating hemorrhoids according to claim 1, characterized by: The mass ratio of the raw materials in the first suppository core to the raw materials in the second suppository core is 1:0.5-1:

2.

4. The three-ingredient hemorrhoid suppository for treating hemorrhoids according to claim 1, characterized by: The mass ratio of the gallnut, alum and menthol is 80:25:

10.

5. The preparation method of the three-ingredient hemorrhoid suppository for treating hemorrhoids according to claim 1, characterized in that: The specific preparation process is as follows: (1) lidocaine hydrochloride suppository shell is prepared, the water-soluble base is heated and melted, lidocaine hydrochloride is added, the temperature is kept at 40-50°C, a steel pipe is inserted into the middle part of the suppository mold, the mixture of the water-soluble base and lidocaine hydrochloride is injected between the suppository mold and the steel pipe, and after cooling and solidification, the steel pipe is pulled out, and the suppository core is poured into the cavity; (2) the suppository core is poured, the semi-synthetic fatty acid glyceride fatty base is heated and melted, part of the mixed traditional Chinese medicine raw materials is added, and the first suppository core is formed by quantitatively injecting the mixture into the hollow part of the suppository shell; Then, the fatty base glycerol trilaurate is heated and melted, the remaining mixed traditional Chinese medicine raw materials is added, and the second suppository core is formed by continuously quantitatively injecting the mixture into the hollow part of the suppository shell; cooling, mold opening, taking medicine, packaging, and obtaining the three-ingredient hemorrhoid suppository.

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