Mitral annuloplasty system

Abstract

The application provides a mitral annuloplasty system, which comprises a proximal anchor, a push rod, a protective sleeve and a delivery handle; the proximal anchor is used for anchoring in a human body, and the proximal end of the proximal anchor is provided with a proximal anchor connector; the push rod has flexibility at least in the part of the human body, the proximal end of the push rod is connected with the delivery handle, the distal end of the push rod is provided with a push rod connector, and the push rod connector and the proximal anchor connector can be buckled with each other; the protective sleeve has flexibility, the proximal end of the protective sleeve is connected with the delivery handle, the distal end of the protective sleeve can be sleeved on the connection part of the push rod connector and the proximal anchor connector, and the push rod connector and the proximal anchor connector are limited to prevent the push rod connector and the proximal anchor connector from loosening; and after the protective sleeve is removed, the push rod connector can be separated from the proximal anchor connector under the elastic action of the push rod, so that the flexibility of the push rod connector and the push rod is better, and the push rod can be bent and withdrawn from the human body smoothly.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a mitral annuloplasty system. BACKGROUND

[0002] The mitral valve is a complex tissue structure between the left atrium (LA) and the left ventricle (LV), which is composed of the mitral annulus, the anterior leaflet of the mitral valve, the posterior leaflet of the mitral valve, the chordae tendineae of the mitral valve, and the papillary muscle. The mitral valve acts as a gatekeeper, ensuring that blood can only flow from the left atrium to the left ventricle and not in the opposite direction. In a healthy mitral valve, the geometry of the mitral valve ensures that the leaflets overlap each other to prevent backflow of blood during left ventricular contraction. Dilated cardiomyopathy caused by disease or certain natural defects can impair the normal function of the mitral valve in preventing regurgitation. For example, certain diseases can cause the mitral annulus to dilate, the mitral valve geometry to deform, and the mitral valve to be incompetent during left ventricular contraction, resulting in blood leakage and regurgitation.

[0003] Surgery is an effective method for treating mitral valve incompetence, but for elderly patients with a history of thoracotomy, poor cardiac function, and multiple organ dysfunction, the surgical trauma is large, healing is difficult, complications are many, and the risk is great, and even some patients cannot tolerate it. With the continuous improvement of medical level, now through minimally invasive interventional surgery treatment is a better choice for most heart valve diseases, the main interventional treatment methods are artificial chordae tendineae implantation, mitral annuloplasty, and mitral valve edge-to-edge repair, etc. Among them, annuloplasty has two types of direct annuloplasty and indirect annuloplasty. Indirect annuloplasty mainly uses the blood vessel tissue around the mitral annulus to contract the mitral annulus to make the mitral valve leaflets close tightly. The coronary sinus-cardiac great vein is a blood vessel that surrounds the mitral annulus, which makes it the best implant object for indirect annuloplasty.

[0004] At present, an indirect annuloplasty is disclosed, which enters the body through the jugular vein and implants a device in the coronary sinus and the cardiac great vein. The device has two anchors, a distal anchor anchored in the cardiac great vein, and a proximal anchor anchored in the coronary sinus, connected by a core wire. By tightening the device, inward pressure is applied to the mitral annulus, the mitral annulus contracts, and the normal geometry is basically restored, so that the mitral valve leaflets close tightly and the mitral valve regurgitation is improved. In actual application, when the implant device is implanted from the jugular vein to the coronary sinus, the bending angle is large, and when the implant device is released, part of the delivery device that intervenes in the human body needs to be bent and withdrawn. However, in the existing implant device, the delivery device that intervenes in the human body is not flexible enough in structure, resulting in incomplete and stable withdrawal. SUMMARY

[0005] The application provides a mitral annuloplasty system to solve the technical problem that the intervention in the human body is not flexible enough to be withdrawn from the human body.

[0006] To solve the above problems, the technical scheme provided by the embodiments of the application is as follows: a mitral annuloplasty system, comprising a proximal anchor, a push rod, a protective sleeve and a delivery handle; the proximal anchor is used for anchoring in the human body, and the proximal end of the proximal anchor is provided with a proximal anchor connector; the push rod has flexibility at least in the part of the human body, the proximal end of the push rod is connected with the delivery handle, the distal end of the push rod is provided with a push rod connector, and the push rod connector and the proximal anchor connector can be mutually buckled.

[0007] The protective sleeve has flexibility, the proximal end of the protective sleeve is connected with the delivery handle, the distal end of the protective sleeve can be sleeved at the connection between the push rod connector and the proximal anchor connector, and the push rod connector and the proximal anchor connector are limited to prevent the push rod connector and the proximal anchor connector from loosening; and after the protective sleeve is removed, the push rod connector can be mutually separated from the proximal anchor connector under the elastic action of the push rod.

[0008] According to the mitral annuloplasty system provided by the embodiments of the application, the protective sleeve and the push rod are both provided with flexible structures, the push rod connector on the push rod and the proximal anchor connector on the proximal anchor are mutually buckled, the protective sleeve is used for limiting the push rod connector and the proximal anchor connector to prevent the push rod connector and the proximal anchor connector from loosening, the position of the proximal anchor can be adjusted through the push rod when the protective sleeve is in place, and when the push rod needs to be withdrawn, the protective sleeve only needs to be withdrawn, the push rod connector can be withdrawn from the proximal anchor connector under the elastic action of the push rod, and then the push rod and the push rod connector are withdrawn from the human body through the delivery handle. Since the push rod itself has flexibility, and the push rod connector and the proximal anchor are mutually buckled without requirement on the structural hardness of the push rod connector, that is, the flexibility of the push rod connector can be better, so that the push rod 1 can be bent and withdrawn smoothly.

[0009] In a possible design, the push rod connector and the proximal anchor connector are mutually buckled in a direction perpendicular to the axial direction of the push rod.

[0010] In a possible design, the push rod connector and the proximal anchor connector are both provided with an S-shaped structure in the axial cross section, and the overall outer surface of the push rod connector and the proximal anchor connector after being mutually buckled in the radial direction is in a cylindrical shape.

[0011] In a possible design, at least two first clamping grooves are formed in the outer periphery of the proximal anchor connector.

[0012] The push rod connector comprises a first body part connected with the push rod and at least two first elastic petals arranged at the end of the first body part away from the push rod;

[0013] The at least two first elastic petals are respectively buckled in the at least two first clamping grooves under the limiting action of the protective sleeve, and the at least two first elastic petals can be ejected from the at least two first clamping grooves after the protective sleeve is removed.

[0014] In a possible design, the mitral annuloplasty system further comprises a distal anchor, a locking wire and a pushing member; the distal anchor is used for anchoring in the human body; the pushing member and the locking wire are flexible members, the distal end of the locking wire is fixed to the proximal end of the distal anchor, the locking wire passes through the proximal anchor, the proximal end of the locking wire and the distal end of the pushing member form detachable connection, and the proximal end of the pushing member is connected with the delivery handle;

[0015] The push rod is sleeved outside the pushing member and the locking wire; the pushing member can be separated from the locking wire after the push rod is removed or under the driving of the delivery handle.

[0016] In a possible design, the proximal end of the locking wire is provided with a locking wire connector, the pushing member is a core wire, the distal end of the core wire is provided with a core wire connector, and the core wire connector and the locking wire connector are mutually buckled;

[0017] The push rod is sleeved outside the core wire connector and the locking wire connector, the push rod limits the core wire connector and the locking wire connector to keep the core wire connector and the locking wire connector mutually buckled, and the core wire connector and the locking wire connector can be mutually separated under the elastic action of the core wire after the push rod is removed.

[0018] In a possible design, the core wire connector and the locking wire connector are solid structures with S-shaped axial cross sections, and the overall outer surface of the core wire connector and the locking wire connector mutually buckled along the radial direction is cylindrical.

[0019] In a possible design, the outer periphery of the locking wire connector is provided with at least two second clamping grooves;

[0020] The core wire connector comprises a second body part connected with the core wire and at least two second elastic petals arranged at the end of the second body part away from the core wire;

[0021] The at least two second elastic petals are respectively buckled in the at least two second clamping grooves under the limiting action of the push rod, and the at least two second elastic petals can be ejected from the at least two second clamping grooves after the push rod is removed.

[0022] In a possible design, the inner diameter of the proximal anchor connector is greater than the outer diameter of the locking wire connector.

[0023] In a possible design, the pushing member is a connecting rope, the proximal end of the locking wire is provided with a locking rope mounting member, the middle part of the connecting rope passes through the locking rope mounting member, and the two ends of the connecting rope are connected to the delivery handle.

[0024] In a possible design, the locking rope mounting member is a ring structure provided at the proximal end of the locking wire, and the middle part of the connecting rope passes through the ring structure.

[0025] In a possible design, the locking rope mounting member is a cylindrical structure with a diameter greater than that of the locking wire, a socket is formed at the center of the proximal end of the locking rope mounting member, and a bayonet is formed in the outer periphery of the locking rope mounting member and communicates with the socket; the middle part of the connecting rope is embedded in the bayonet; the mitral annulus reduction system further comprises a first limiting wire, the proximal end of the first limiting wire is connected to the delivery handle, and the distal end of the first limiting wire is inserted into the socket and passes through the connecting rope at the bayonet.

[0026] In a possible design, the bayonet is provided with an inclined first guide surface close to the inner wall of the delivery handle.

[0027] In a possible design, the locking rope mounting member comprises a sleeve and a hanging ring, the hanging ring is connected to the proximal end of the locking wire, the sleeve is sleeved at the connection between the locking wire and the hanging ring, and the hanging ring at least partially extends out of the sleeve; the mitral annulus reduction system further comprises a second limiting wire, the middle part of the connecting rope is staggered with the hanging ring, the proximal end of the second limiting wire is connected to the delivery handle, and the distal end of the second limiting wire sequentially passes through the hanging ring and the connecting rope and is inserted into the sleeve.

[0028] In a possible design, the locking rope mounting member is a cylindrical structure with a diameter greater than that of the locking wire, a notch is formed in the outer periphery of the locking rope mounting member, and the middle part of the connecting rope is clamped in the notch; the gap between the outer diameter of the locking rope mounting member and the inner diameter of the push rod is smaller than the wire diameter of the connecting rope, the push rod is sleeved outside the notch so that the connecting rope cannot be separated from the notch, and the connecting rope can be separated from the notch after the push rod is separated. BRIEF DESCRIPTION OF DRAWINGS

[0029] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or prior art description will be briefly introduced below. Obviously, the drawings in the following description are some embodiments of the present application, and those skilled in the art can also obtain other drawings according to these drawings without creative labor.

[0030] Figure 1 is a structural schematic view of an implanting device of a mitral annuloplasty system provided by an embodiment of the present application;

[0031] Figure 2 is a structural schematic view of a delivery device of a mitral annuloplasty system provided by an embodiment of the present application;

[0032] Figure 3 is an exploded schematic view of the delivery device of the mitral annuloplasty system provided by an embodiment of the present application;

[0033] Figure 4 is an assembly sectional view of a locking wire, a core wire, a push rod, a locking structure and a protective sleeve provided by an embodiment of the present application;

[0034] Figure 5 is an exploded schematic view of the locking wire, the core wire, the push rod and the protective sleeve provided by an embodiment of the present application;

[0035] Figure 6 is a connection schematic view of the locking wire and the core wire provided by an embodiment of the present application;

[0036] Figure 7 is a connection schematic view of the locking structure and the push rod provided by an embodiment of the present application;

[0037] Figure 8 is Figure 7 a structural schematic view of the protective sleeve sleeved at a connection position of the push rod and the locking structure provided by an embodiment of the present application;

[0038] Figure 9 is an exploded schematic view of a push rod connecting member and a proximal end anchor connecting member provided by an embodiment of the present application;

[0039] Figure 10 is Figure 9 an assembly schematic view of the push rod connecting member and the proximal end anchor connecting member provided by an embodiment of the present application;

[0040] Figure 11 is an assembly schematic view of a locking rope installing member and a connecting rope provided by an embodiment of the present application;

[0041] Figure 12 is an assembly schematic view of the locking rope installing member and the connecting rope provided by an embodiment of the present application;

[0042] Figure 13 is an assembly schematic view of the locking rope installing member and the connecting rope provided by an embodiment of the present application;

[0043] Figure 14 is an assembly schematic view of the locking rope installing member and the connecting rope provided by an embodiment of the present application;

[0044] Figure 15 is Figure 14The middle push rod sleeve is arranged on the lock rope mounting member and the assembly schematic view of the connecting rope outside.

[0045] Reference signs: 10, distal anchor; 20, proximal anchor; 21, proximal anchor connecting member; 211, first clamping groove; 30, lock wire; 31, lock wire connecting member; 32, lock rope mounting member; 321, insertion hole; 322, bayonet; 323, first guide surface; 324, sleeve; 325, hanging ring; 326, notch; 327, second guide surface; 40, lock structure; 50, delivery handle; 60, lock control member; 70, unlocking rope; 81, core wire; 811, core wire connecting member; 821, core wire knob; 8221, first fixing member; 8222, second fixing member; 91, push rod; 911, push rod connecting member; 9111, first body part; 9112, first elastic flap; 921, push rod knob; 922, push rod fixing member; 100, protective sleeve; 111, protective sleeve knob; 112, protective sleeve fixing member; 120, connecting rope; 130, first limiting wire; 140, second limiting wire. DETAILED DESCRIPTION

[0046] To make the objectives, technical solutions, and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are some but not all of the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0047] In the description of the present application, the meaning of “multiple” is at least two, for example, two, three, etc., unless otherwise explicitly specified. In the present application, unless otherwise explicitly specified and limited, the terms “mounting”, “connecting”, “connecting”, “fixing” and the like should be understood in a broad sense, for example, can be fixedly connected, or can be detachably connected, or can be integrated; can be directly connected, or can be indirectly connected through an intermediate medium; can be the internal communication of two elements or the interaction relationship between two elements, unless otherwise explicitly limited. For a person of ordinary skill in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0048] In the present application, unless otherwise explicitly specified and limited, a first feature is "on" or "under" a second feature can be that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature is "above", "over" and "on" the second feature can be that the first feature is directly above or obliquely above the second feature, or only indicates that the first feature is higher in horizontal height than the second feature. The first feature is "below", "under" and "under" the second feature can be that the first feature is directly below or obliquely below the second feature, or only indicates that the first feature is lower in horizontal height than the second feature.

[0049] In the description of the present application, it should be understood that the terms "inner", "outer", "upper", "bottom", "front", "back" and the like indicate the orientation or positional relationship (if any) based on the drawings shown, and only for the purpose of facilitating the description of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. Figure 1

[0050] It should also be noted that the same reference signs are used to represent the same components or the same parts in the embodiments of the present application. For the same parts in the embodiments of the present application, only one part or component may

[0051] The embodiments of the present application provide a mitral annuloplasty system, which comprises a delivery device and an implant device. The delivery device is connected with the implant device, and is used to deliver the implant device into the human body. The implant device is used to be implanted into the human body to achieve the annuloplasty effect on the mitral valve.

[0052] Please refer to Figure 1 The implant device comprises a distal anchor 10, a proximal anchor 20, a lock structure 40 and a lock wire 30.

[0053] The distal anchor 10 is used to anchor in the human body, specifically in the great cardiac vein. Specifically, the distal anchor 10 is configured as a self-expanding anchor, which has two states of a compressed state and an expanded state. In the compressed state, the distal anchor 10 can be inserted into the coronary sinus or other coronary vessels, and in the expanded state, the distal anchor 10 is in close contact with the blood vessel wall of the great cardiac vein after self-expanding, thereby supporting the blood vessel and anchoring in the blood vessel. Specifically, the distal anchor 10 can be selected from common self-expanding anchors, which can be a metal anchor cut from a shape memory metal, or a balloon structure capable of self-expanding, which can be selected according to actual needs.

[0054] ​The proximal anchor 20 is used to anchor in the human body, in particular, anchor in the coronary sinus. Specifically, the proximal anchor 20 is also configured as a self-expanding anchor, which has two states of compression state and expansion state. In the compression state, the proximal anchor 20 can be inserted into the internal coronary sinus through the jugular vein, and in the expansion state, the proximal anchor 20 is in contact with the coronary sinus by self-expanding, thereby anchoring in the coronary sinus.

[0055] The lock structure 40 is fixed to the proximal end of the proximal anchor 20, specifically, the lock structure 40 is integrally connected with the proximal anchor 20. The lock structure 40 is in a normally closed state, and the lock structure 40 is provided with an unlocking rope 70, which is used to control the opening and closing of the lock structure 40.

[0056] Please refer to Figures 2 to 4 , the delivery device includes a delivery handle 50, a lock control member 60, a protective sleeve 100, a pushing member and a push rod 91.

[0057] The lock control member 60 is installed on the delivery handle 50, and the unlocking rope 70 is connected to the lock control member 60. The unlocking rope 70 is controlled by the lock control member 60, thereby controlling the opening and closing of the lock structure 40.

[0058] The pushing member is a core wire 81, and the lock wire 30 and the core wire 81 are both flexible members. The distal end of the lock wire 30 is fixed to the proximal end of the distal anchor 10, the lock wire 30 passes through the proximal anchor 20 and the lock structure 40 in turn, the proximal end of the lock wire 30 is detachably connected with the distal end of the core wire 81, and the proximal end of the core wire 81 is connected to the delivery handle 50. When the lock control member 60 controls the lock structure 40 to be in a closed state through the unlocking rope 70, the lock structure 40 locks the lock wire 30, that is, the lock wire 30 cannot slide relative to the lock structure 40, so the position of the distal anchor 10 cannot be adjusted; when the lock control member 60 controls the lock structure 40 to be in an open state through the unlocking rope 70, the lock structure 40 releases the lock wire 30, so that the lock wire 30 can slide relative to the lock structure 40, and then the delivery handle 50 can drive the lock wire 30 and the distal anchor 10 to move through the core wire 81, so that the proximal anchor 20 and the distal anchor 10 can slide relative to each other.

[0059] The push rod 91 is at least flexible in the part of the human body, and the push rod 91 is sleeved on the core wire 81 and the lock wire 30. The core wire 81 can be separated from the lock wire 30 after the push rod 91 is removed or under the drive of the delivery handle 50. For example, when the core wire 81 is a connecting rope, only one end of the opposite two ends of the connecting rope needs to be pulled at the delivery handle 50, so that the connecting rope can be separated from the lock wire 30; for another example, when the core wire 81 is a flexible metal wire, the push rod 91 can be removed from the connection between the core wire 81 and the lock wire 30, and then the core wire 81 and the lock wire 30 are separated from each other by using their own elasticity.

[0060] The proximal end of the push rod 91 is connected with the delivery handle 50, and the distal end of the push rod 91 is provided with a push rod connector 911. The proximal end of the proximal anchor 20 is provided with a proximal anchor connector 21, and the push rod connector 911 and the proximal anchor connector 21 are buckled with each other. The protective sleeve 100 has flexibility, the proximal end of the protective sleeve 100 is connected with the delivery handle 50, the protective sleeve 100 is sleeved on the connection between the push rod connector 911 and the proximal anchor connector 21, and the protective sleeve 100 and the push rod connector 911 and the proximal anchor connector 21 are limited to prevent the push rod connector 911 and the proximal anchor connector 21 from being loosened. After the protective sleeve 100 is removed, the push rod connector 911 can be separated from the proximal anchor connector 21 under the elastic action of the push rod 91.

[0061] It should be noted that the protective sleeve 100 is also a flexible member capable of being inserted into the human body. The push rod connector 911 and the proximal anchor connector 21 are buckled with each other. When the protective sleeve 100 is sleeved on the connection between the push rod connector 911 and the proximal anchor connector 21, the push rod connector 911 and the proximal anchor connector 21 are limited by the protective sleeve 100, so that the push rod connector 911 and the proximal anchor connector 21 cannot be loosened from each other. When the delivery handle 50 drives the push rod 91 to move, the proximal anchor 20 can also be driven to move, so as to realize the position adjustment of the proximal anchor 20. When the position of the proximal anchor 20 is adjusted, the push rod 91 needs to be withdrawn from the human body. First, the protective sleeve 100 is removed from the connection between the push rod connector 911 and the proximal anchor connector 21. In addition, the push rod 91 has elasticity, which drives the push rod connector 911 and the proximal anchor connector 21 to be separated from each other. Finally, the protective sleeve 100, the push rod 91 and the core wire 81 are withdrawn from the human body through the delivery handle 50.

[0062] In addition, when the core wire 81 is a metal structure with flexibility, the connection mode of the core wire 81 and the lock wire 30 can be set to be the same as the connection mode of the push rod 91 and the proximal anchor 20.

[0063] The mitral annulus reduction system of the present application, by the setting of the distal anchor 10, the proximal anchor 20, the locking wire 30, the core wire 81, the push rod 91, the protective sleeve 100 and the delivery handle 50, the distal end of the locking wire 30 is connected with the proximal end of the proximal anchor 20, the proximal end of the locking wire 30 is connected with the distal end of the core wire 81, the distal end of the core wire 81 is connected with the delivery handle 50, and the proximal end of the proximal anchor 20 is connected with the distal end of the push rod 91, the proximal end of the push rod 91 is connected with the delivery handle 50, then the distal anchor 10, the proximal anchor 20 and the locking wire 30 can be implanted in the corresponding position of the human body through the delivery handle 50, the push rod 91 and the core wire 81 together, and the position of the distal anchor 10 and the proximal anchor 20 can be adjusted through the delivery handle 50, so as to more facilitate the adjustment of the annular reduction degree of the proximal anchor 20 and the distal anchor 10 to the mitral valve, so as to achieve better annular reduction effect. At the same time, by setting the protective sleeve 100 and the push rod 91 as a structure with flexibility, the push rod connector 911 on the push rod 91 and the proximal anchor connector 21 on the proximal anchor 20 are mutually buckled, the protective sleeve 100 is used to limit the push rod connector 911 and the proximal anchor connector 21 to prevent the push rod connector 911 and the proximal anchor connector 21 from loosening, then when the protective sleeve 100 is in, the position of the proximal anchor 20 can be adjusted through the push rod 91, when it is needed to withdraw the push rod 91, only the protective sleeve 100 needs to be withdrawn, the push rod connector 911 can be withdrawn from the proximal anchor connector 21 under the elastic action of the push rod 91, and then the push rod 91 and the push rod connector 911 are withdrawn from the human body through the delivery handle 50, since the push rod 91 itself has flexibility, and the push rod connector 911 and the proximal anchor 20 are mutually buckled, there is no requirement for the structural hardness of the push rod connector 911, that is, the flexibility of the push rod connector 911 can be made better, so that the push rod 91 can be smoothly bent and withdrawn.

[0064] The locking wire 30 is an implanted human structure, and the locking wire 30 is processed from medical implant-grade metal materials, such as 316LVM stainless steel, nickel-titanium alloy, cobalt-chromium alloy, etc.

[0065] The locking wire 30 can be made of a single metal wire with a diameter of 0.4-1.0 mm, and the surface can be roughened, such as knurling, to increase the friction during locking. The locking wire 30 can also be made of multiple wires that are twisted and braided together, and the diameter of the braided locking wire 30 is within the range of 0.4-1.0 mm. For example, three wires with the same diameter are twisted and braided together to form a 1x3 multi-wire, which forms the locking wire 30. For another example, three wires with the same diameter are twisted and braided together to form a small multi-wire, and then three small multi-wires are twisted and braided together to form a 3x3 large multi-wire, which forms the locking wire 30. The use of multiple wires to make the locking wire 30 can increase flexibility, allowing the locking wire 30 to conform to the curvature of the heart and blood vessels as much as possible, avoiding damage to the heart due to excessive rigidity. For another example, three wires with the same diameter are twisted and braided together to form a small multi-wire, and then nine wires are continuously twisted and braided around the small multi-wire to tightly wrap the three multi-wires, forming a large multi-wire, which forms the locking wire 30.

[0066] The core wire 81 is a structure for intervention in the human body, and is made of medical intervention-grade metal materials, such as 304V stainless steel, 316LVM stainless steel, nickel-titanium alloy, cobalt-chromium alloy, etc. In addition, the core wire 81 can be made of a single metal wire or multiple metal wires twisted and braided together, similar to the manufacturing process of the locking wire 30, which will not be described again here.

[0067] The push rod 91 is made of medical intervention-grade metal materials, such as 304V stainless steel, 316LVM stainless steel, nickel-titanium alloy, cobalt-chromium alloy, etc.

[0068] The distal end of the push rod 91 is made of a metal tube with good flexibility after processing, such as a spring tube or a snake bone tube, which facilitates the intervention of the push rod 91 in the human body. The proximal end of the push rod 91 is made of a metal tube with good pushability without special processing, such as a stainless steel tube or a hypotube, which facilitates the pushing of the front end of the push rod 91.

[0069] The protective sleeve 100 is made of medical intervention high-molecular materials, such as polyethylene (PE).

[0070] In one embodiment, the push rod connector 911 and the proximal anchor connector 21 are buckled to each other in a direction perpendicular to the axial direction of the push rod 91, and the protective sleeve 100 is sleeved on the connection between the push rod connector 911 and the proximal anchor connector 21, and is used to limit the push rod connector 911 and the proximal anchor connector 21 in a direction perpendicular to the axial direction of the push rod 91, to prevent the push rod connector 911 and the proximal anchor connector 21 from coming off each other. It can be understood that in other embodiments of the present application, the buckling direction of the push rod connector 911 and the proximal anchor connector 21 can also be at an angle to the axial direction of the push rod 91, which is not particularly limited here.

[0071] In one embodiment, please refer toFigures 4 to 8 The push rod connecting piece 911 and the proximal end anchor connecting piece 21 are both hollow structures with an S-shaped axial cross section, and the overall outer surface of the push rod connecting piece 911 and the proximal end anchor connecting piece 21 after being radially buckled together is cylindrical.

[0072] It should be noted that the axial cross section refers to a cross section parallel to the center axis of the push rod. The push rod connecting piece 911 and the proximal end anchor connecting piece 21 are radially concave-convex matched, so that after being buckled together, the overall shape is cylindrical. The push rod connecting piece 911 and the proximal end anchor connecting piece 21 can slide in the protective sleeve 100 after being buckled together. In the present application, the push rod connecting piece 911 and the proximal end anchor connecting piece 21 are arranged in an S-shaped buckling structure, so that after being buckled together, the connection stability in the protective sleeve 100 is good, which is beneficial to the movement driving of the push rod 91 and the proximal end anchor 20 by the delivery handle 50. It can be understood that in other embodiments of the present application, there are many connection modes of the push rod connecting piece 911 and the proximal end anchor connecting piece 21, as long as they can be radially buckled together and radially loosened. The shape of the push rod connecting piece 911 and the proximal end anchor connecting piece 21 is not limited, for example, it can be in the form of protrusion, groove, or in the form of column, arc, etc. which is not particularly limited here.

[0073] The push rod connecting piece 911 is fixedly connected with the push rod 91 by pressure riveting or welding.

[0074] The outer diameter of the push rod 91 is smaller than the outer diameter of the push rod connecting piece 911, and the inner diameter of the push rod 91 is the same as the inner diameter of the push rod connecting piece 911. The push rod 91 is inserted into the distal end of the push rod connecting piece 911 to form a fixed connection with the push rod connecting piece 911.

[0075] The push rod connecting piece 911 is processed from medical intervention grade metal materials, such as 304V stainless steel, 316LVM stainless steel, nickel-titanium alloy, cobalt-chromium alloy, etc. The proximal end anchor connecting piece 21 is processed from medical implant grade metal materials, such as 316LVM stainless steel, nickel-titanium alloy, cobalt-chromium alloy, etc.

[0076] In one embodiment, referring to Figures 4 to 7 The proximal end of the locking wire 30 is provided with a locking wire connecting piece 31, and the distal end of the core wire 81 is provided with a core wire connecting piece 811. The core wire connecting piece 811 and the locking wire connecting piece 31 are radially buckled together. The push rod 91 is sleeved outside the core wire connecting piece 811 and the locking wire connecting piece 31, and the push rod 91 limits the core wire connecting piece 811 and the locking wire connecting piece 31 to keep them buckled together. The core wire connecting piece 811 and the locking wire connecting piece 31 can be separated from each other under the elastic action of the core wire 81 after the push rod 91 is removed.

[0077] It should be noted that the push rod 91 is a flexible member capable of being inserted into the human body, the locking wire connecting member 31 and the core wire connecting member 811 are radially buckled with each other, when the push rod 91 is sleeved on the connection between the locking wire connecting member 31 and the core wire connecting member 811, the locking wire connecting member 31 and the core wire connecting member 811 are limited by the push rod 91, so that the locking wire connecting member 31 and the core wire connecting member 811 cannot be mutually released, and when the delivery handle 50 drives the core wire 81 to move, the distal anchor 10 can also be driven to move by the locking wire 30, so as to adjust the relative position of the distal anchor 10 and the proximal anchor 20. At the same time, when the position of the distal anchor 10 is adjusted, the core wire 81 needs to be withdrawn from the human body, the push rod 91 is first removed from the connection between the locking wire connecting member 31 and the core wire connecting member 811, and then the core wire 81 and the locking wire 30 are both elastic, which drives the core wire connecting member 811 and the locking wire connecting member 31 to be radially separated, and finally the protective sleeve 100, the push rod 91 and the core wire 81 are withdrawn from the human body by the delivery handle 50.

[0078] In one embodiment, the locking wire connecting member 31 and the core wire connecting member 811 are both solid structures with S-shaped axial cross sections, and the overall outer surface of the locking wire connecting member 31 and the core wire connecting member 811 after being radially buckled with each other is cylindrical.

[0079] It should be noted that the axial cross section refers to the cross section parallel to the center axis of the core wire 81. The locking wire connecting member 31 and the core wire connecting member 811 are radially concave-convex matched, so that the overall shape is cylindrical after buckling. The locking wire connecting member 31 and the core wire connecting member 811 can slide in the push rod 91 after being buckled with each other. The locking wire connecting member 31 and the core wire connecting member 811 are arranged in an S-shaped buckling structure in the application, so that the connection stability in the push rod 91 is good after buckling, which is beneficial to the movement driving of the delivery handle 50 to the core wire 81 and the locking wire 30. It can be understood that in other embodiments of the application, there are many connection modes of the locking wire connecting member 31 and the core wire connecting member 811, as long as they can be radially buckled with each other and radially released, and the shape of the locking wire connecting member 31 and the core wire connecting member 811 is not limited, for example, it can be in the form of protrusion, groove, column, arc, etc. which is not particularly limited here.

[0080] Specifically, please refer to Figure 4The lock wire connecting piece 31 and the core wire connecting piece 811 both belong to solid structure, and the outer diameters of the two are the same. The lock wire connecting piece 31 is matched with the core wire connecting piece 811 in structure, and the two are cylindrical after being buckled with each other. The diameter of the lock wire 30 is smaller than the outer diameter of the lock wire connecting piece 31. The lock wire 30 is inserted into the inner hole of the lock wire connecting piece 31 and is fixed together by riveting or welding. The diameter of the core wire 81 is smaller than the outer diameter of the core wire connecting piece 811. The core wire 81 is inserted into the inner hole of the core wire connecting piece 811 and is fixed together by riveting or welding. The outer diameter of the push rod 91 is smaller than the outer diameter of the push rod connecting piece 911. The inner diameter of the push rod 91 is the same as the inner diameter of the push rod connecting piece 911. The push rod 91 is inserted into the inner hole of the push rod connecting piece 911 and is fixed together by riveting or welding. The inner diameter of the push rod connecting piece 911 and the push rod 91 is matched, and is about 0.5 mm larger than the outer diameter of the lock wire connecting piece 31, so that the lock wire connecting piece 31 can slide in the push rod 91. The push rod 91 is sleeved outside the lock wire connecting piece 31 and the core wire connecting piece 811, so as to ensure that the lock wire connecting piece 31 and the core wire connecting piece 811 are not loosened. The outer diameter of the proximal end anchor connecting piece 21 is the same as the outer diameter of the push rod connecting piece 911. The inner diameter of the proximal end anchor connecting piece 21 is matched with the outer diameter of the lock wire 30. The inner diameter of the proximal end anchor connecting piece 21 is about 0.5 mm larger than the outer diameter of the lock wire 30, but is smaller than the outer diameter of the lock wire connecting piece 31. The lock wire 30 can smoothly pass through the inner hole of the proximal end anchor connecting piece 21, but the lock wire connecting piece 31 cannot pass through, so as to avoid that the lock wire connecting piece 31 enters the adjustable lock. The proximal end anchor connecting piece 21 is matched with the push rod connecting piece 911 in structure. The proximal end anchor connecting piece 21 and the push rod connecting piece 911 are cylindrical after being buckled with each other. The protective sleeve 100 is sleeved outside the proximal end anchor connecting piece 21 and the push rod connecting piece 911, so as to ensure that the proximal end anchor connecting piece 21 and the push rod connecting piece 911 are not loosened.

[0081] In one embodiment, the inner diameter of the proximal end anchor connecting piece 21 is larger than the outer diameter of the lock wire connecting piece 31, so as to prevent the lock wire connecting piece 31 from passing through the proximal end anchor connecting piece 21 and causing the lock wire connecting piece 31 and the core wire connecting piece 811 to be unlocked.

[0082] Please refer to Figure 2 and Figure 3The core wire knob 821, the first fixing member 8221 and the second fixing member 8222 are arranged on the delivery handle 50. The first fixing member 8221 is movably sleeved outside the core wire 81, the second fixing member 8222 is used for fixing the core wire 81 on the first fixing member 8221, and the core wire knob 821 is threadedly sleeved on the first fixing member 8221. Specifically, the inner diameter of the first fixing member 8221 is larger than the outer diameter of the core wire 81 by about 0.5 mm, so that the relative sliding between the core wire 81 and the first fixing member 8221 is ensured, the second fixing member 8222 is fixed to the proximal end of the first fixing member 8221 by glue, and the inner diameter of the second fixing member 8222 is in interference fit with the outer diameter of the core wire 81, so that the core wire 81 can be fixed on the first fixing member 8221 through the second fixing member 8222. When it is necessary to adjust the position of the core wire 81, the first fixing member 8221 can be driven to move by rotating the core wire knob 821, so as to drive the second fixing member 8222 and the core wire 81 to move, and then the displacement of the lock wire 30 and the distal anchor 10 is realized. When the installation is performed, the initial positions of the core wire 81, the lock wire 30 and the distal anchor 10 can be adjusted by pulling the second fixing member 8222 before the second fixing member 8222 and the first fixing member 8221 are fixed to each other.

[0083] Please refer to Figure 2 and Figure 3 The delivery handle 50 is further provided with a push rod knob 921 and a push rod fixing member 922. The push rod fixing member 922 is fixed to the proximal end of the push rod 91 and is slidably arranged on the delivery handle 50. The push rod knob 921 is rotationally arranged on the delivery handle 50 and is threadedly sleeved on the push rod fixing member 922. When it is necessary to adjust the position of the proximal anchor 20, the push rod knob 921 is rotated on the delivery handle 50. Since the push rod knob 921 and the push rod fixing member 922 are in threaded transmission connection, the rotation of the push rod knob 921 is converted into the sliding of the push rod fixing member 922 on the delivery handle 50, so as to drive the proximal anchor 20 to move through the push rod 91, so as to adjust the position of the proximal anchor 20. The adjustment of the position of the proximal anchor 20 can be realized by rotating the push rod knob 921, which is simple in adjustment, stable in transmission, high in adjustment precision and suitable for the adjustment of the human body implantation device.

[0084] Please refer to Figure 2 and Figure 3The delivery handle 50 is also equipped with a protective sleeve knob 111 and a protective sleeve fixing member 112. The protective sleeve fixing member 112 is fixed to the proximal end of the protective sleeve 100 and is slidably disposed in the delivery handle 50. The protective sleeve knob 111 is rotatably disposed on the delivery handle 50 and is threadedly sleeved on the protective sleeve fixing member 112. When it is necessary to move the protective sleeve 100, the protective sleeve knob 111 is rotated on the delivery handle 50. Since the protective sleeve knob 111 and the protective sleeve fixing member 112 are connected by a threaded transmission, the rotation of the protective sleeve knob 111 is converted into the sliding of the protective sleeve fixing member 112 on the delivery handle 50, thereby driving the protective sleeve 100 to move. For example, after the implantation device has been adjusted, the protective sleeve 100 can be removed from the human body. This application allows the protective sleeve 100 to be moved by rotating the protective sleeve knob 111. The adjustment is simple, the transmission is smooth, and the adjustment accuracy is high, making it suitable for the operation of human implantation devices. It is understood that in other embodiments of this application, depending on the actual design and specific requirements, the above-mentioned protective sleeve adjustment component 110 may also be of other types, such as a ball screw structure or a gear rack structure, etc., which are not particularly limited here.

[0085] Please see Figures 5 to 8 After the implantation device is implanted, firstly, by rotating the protective sleeve knob 111, the protective sleeve 100 is withdrawn proximally, allowing the push rod connector 911 and the proximal anchor connector 21 to disengage from each other under the elastic force of the push rod 91. Next, by rotating the push rod knob 921, the push rod 91 is withdrawn proximally, allowing the core wire connector 811 and the locking wire connector 31 to disengage from each other under the elastic force of the core wire 81 and the locking wire 30. Finally, by rotating the protective sleeve knob 111, the push rod knob 921, and the core wire knob 821, the protective sleeve 100, the push rod 91, and the core wire 81 are withdrawn from the body together.

[0086] Example 2:

[0087] The technical features of the mitral valve annulus system in this embodiment are the same as those of the mitral valve annulus system in Embodiment 1. The difference is that, in this embodiment, please refer to... Figure 9 and Figure 10The proximal anchor connecting member 21 is in a hollow cylindrical shape, and at least two first clamping grooves 211 are formed on the outer periphery of the proximal anchor connecting member 21, and the at least two first clamping grooves 211 are distributed along the outer periphery of the proximal anchor connecting member 21. The push rod connecting member 911 includes a first body part 9111 and at least two first elastic petals 9112, the first body part 9111 is connected with the distal end of the push rod 91, and the at least two first elastic petals 9112 are respectively arranged at one end of the first body part 9111 away from the push rod 91. The positions of the at least two first elastic petals 9112 and the positions of the at least two first clamping grooves 211 are arranged one by one in the circumferential direction, and the at least two first elastic petals 9112 can be respectively buckled from the outside to the inside in the at least two first clamping grooves 211, so as to realize the radial buckling of the push rod connecting member 911 and the proximal anchor connecting member 21. Then, the protective sleeve 100 is sleeved on the outside of the push rod connecting member 911 and the proximal anchor connecting member 21, and the radial limiting action of the protective sleeve 100 can make the at least two first elastic petals 9112 remain buckled in the at least two first clamping grooves 211, and when the push rod 91 is driven by the delivery handle 50, the proximal anchor 20 can be moved together. When the protective sleeve 100 is removed from the connection between the push rod connecting member 911 and the proximal anchor connecting member 21, the at least two first elastic petals 9112 are separated from the at least two first clamping grooves 211 under the action of elasticity, so that the push rod 91 can be removed from the human body by the delivery handle 50.

[0088] Specifically, the number of first elastic petals 9112 can be two oppositely arranged, or three or more than three distributed in the circumferential direction, which is not particularly limited here.

[0089] In addition, in order to ensure the clamping degree of the first elastic petals 9112 and the first clamping grooves 211, the first elastic petals 9112 can be arranged in a T-shaped structure, so as to prevent the first elastic petals 9112 from being separated from the first clamping grooves 211 in the axial direction.

[0090] Embodiment three:

[0091] The technical features of the mitral annuloplasty system in this embodiment are the same as those of the mitral annuloplasty system in Embodiment One, except that in this embodiment, the locking wire connecting piece 31 is cylindrical, and at least two second clamping grooves (not shown in the figure) are formed in the outer periphery of the locking wire connecting piece 31 and are distributed along the outer periphery of the locking wire connecting piece 31. The core wire connecting piece 811 comprises a second body part and at least two second elastic petals, the second body part is connected to the distal end of the core wire 81, and the at least two elastic petals are respectively arranged at one end of the second body part away from the core wire 81. The positions of the at least two second elastic petals and the positions of the at least two second clamping grooves are arranged one by one in the circumferential direction, and the at least two second elastic petals can be clamped in the at least two second clamping grooves from the outside to the inside, so as to realize the radial clamping of the core wire connecting piece 811 and the locking wire connecting piece 31. Then, by sleeving the push rod 91 outside the core wire connecting piece 811 and the locking wire connecting piece 31, the radial limiting action of the push rod 91 can make the at least two second elastic petals remain clamped in the at least two second clamping grooves, and when the core wire 81 is driven by the delivery handle 50, the distal end anchor 10 can be moved together. When the push rod 91 is removed from the connection between the core wire connecting piece 811 and the locking wire connecting piece 31, the at least two second elastic petals are separated from the at least two second clamping grooves under the action of elasticity, so that the core wire 81 can be removed from the human body by the delivery handle 50.

[0092] Specifically, the number of second elastic petals can be two, or three or more distributed in the circumferential direction, etc., which is not particularly limited here.

[0093] In addition, in order to ensure the clamping degree of the second elastic petals and the second clamping grooves, the second elastic petals can be arranged in a T-shaped structure, so as to prevent the second elastic petals from being separated from the second clamping grooves in the axial direction.

[0094] Embodiment Four:

[0095] The technical features of the mitral annuloplasty system in this embodiment are the same as those of the mitral annuloplasty system in Embodiment One, except that in this embodiment, the locking wire 30 is not delivered by the core wire connecting piece 811 and the delivery handle 50, but is connected to the delivery handle 50 by the connecting rope 120. Specifically, the proximal end of the locking wire 30 is provided with a locking rope mounting piece 32, the pusher is a connecting rope 120, the middle part of the connecting rope 120 is arranged through the locking rope mounting piece 32, and the two ends of the connecting rope 120 are respectively connected to the delivery handle 50. By pulling the two ends of the connecting rope 120 through the delivery handle 50, the movement of the locking wire 30 can be realized, which is simple in structure and convenient to disengage. When disengagement is needed, the two ends of the connecting rope 120 are separated at the delivery handle 50, and then one end is pulled to make the other end pass through the locking rope mounting piece 32 and be disengaged from the locking rope mounting piece 32.

[0096] Specifically, please refer toFigure 11 The locking wire mounting member 32 is a ring structure arranged at the proximal end of the locking wire 30, and the middle part of the connecting wire 120 passes through the ring structure.

[0097] In actual production, the ring structure can be made by bending a single medical implant-grade wire, or by using multiple wires. The ring structure can be connected to the locking wire 30 by welding. The ring structure can also be a medical implant-grade metal sleeve, which is connected to the locking wire 30 by crimping. After the connecting wire 120 passes through the ring structure, the two ends of the connecting wire 120 are connected to the delivery handle 50. When it is necessary to untie, the two ends of the connecting wire 120 are untied from the delivery handle 50, and then one end of the connecting wire 120 is pulled out to complete the untie of the connecting wire 120.

[0098] Embodiment five:

[0099] The technical features of the mitral annuloplasty system in this embodiment are the same as those in embodiment four, and the difference is that in this embodiment, referring to Figure 12 The locking wire mounting member 32 is a cylindrical structure with a diameter larger than that of the locking wire 30. A socket 321 is arranged at the center of the proximal end of the locking wire mounting member 32, and a bayonet 322 is arranged on the outer periphery of the locking wire connector 31 and communicates with the socket 321. The radial depth of the bayonet 322 is greater than the sum of the radius of the locking wire mounting member 32 and the radius of the socket 321, that is, the bayonet 322 extends radially to the socket 321 and penetrates the socket 321. The middle part of the connecting wire 120 is embedded in the bayonet 322, and the two ends of the connecting wire 120 are connected to the delivery handle 50. The mitral annuloplasty system further comprises a first limiting wire 130, the proximal end of which is connected to the delivery handle 50, and the distal end of which is inserted into the socket 321 and penetrates the connecting wire 120 at the bayonet 322. The middle part of the connecting wire 120 is limited in the bayonet 322 by the first limiting wire 130, and then the two ends of the connecting wire 120 are pulled tight, so that the middle part of the connecting wire 120 abuts against the first limiting wire 130, thereby realizing the connection between the connecting wire 120 and the locking wire connector 31. When it is necessary to untie the connecting wire 120, only the distal end of the first limiting wire 130 needs to be pulled out of the socket 321, so that the middle part of the connecting wire 120 is pulled out of the bayonet 322, and then the connecting wire 120 is directly pulled out, which is simple to operate.

[0100] In one embodiment, in order to smoothly insert the middle part of the connecting wire 120 into the bayonet 322 and quickly pull it out of the bayonet 322, a first guide surface 323 is arranged in the bayonet 322. The first guide surface 323 is arranged on the inner wall of the bayonet 322 close to the delivery handle 50, and is inclined to facilitate the sliding of the connecting wire 120.

[0101] After the connecting rope 120 is hooked on the notch 322, it passes through the inner hole of the push rod 91 into the delivery handle 50 and is connected with the first fixing member 8221. The first limiting wire 130 passes through the inner hole of the push rod 91 and is connected with the second fixing member 8222. When the core wire knob 821 is rotated, the connecting rope 120 and the first limiting wire 130 move together, thereby indirectly controlling the distance between the distal anchor 10 and the proximal anchor 20 to realize the ring shrinkage function.

[0102] Embodiment six:

[0103] In this embodiment, the technical features of the mitral valve ring shrinkage system are the same as those of the mitral valve ring shrinkage system in embodiment four. The difference lies in that, in this embodiment, referring to Figure 13 , the locking rope mounting member 32 comprises a sleeve 324 and a hanging ring 325. The hanging ring 325 is connected to the proximal end of the locking wire 30. The sleeve 324 is sleeved on the connection between the locking wire 30 and the hanging ring 325. The hanging ring 325 at least partially extends out of the sleeve 324. The mitral valve ring shrinkage system further comprises a second limiting wire 140. The two ends of the connecting rope 120 are respectively connected to the delivery handle 50. The middle part of the connecting rope 120 is staggered with the hanging ring 325. The proximal end of the second limiting wire 140 is connected to the delivery handle 50. The distal end of the second limiting wire 140 passes through the hanging ring 325 and the connecting rope 120 in turn and is inserted into the sleeve 324. The second limiting wire 140 and the sleeve 324 are connected to form a connection between the hanging ring 325 and the connecting rope 120. When it is necessary to release the connecting rope 120, the second limiting wire 140 is moved to pass out of the hanging ring 325 and the connecting rope 120 respectively, and then the connecting rope 120 is released as a whole at the delivery handle 50, without the need to pull one end of the connecting rope 120 to drive the other end of the connecting rope 120 to pass through various structures in turn and then be released. Thus, the release of the connecting rope 120 is more convenient and fast.

[0104] The tail end of the locking wire 30 is connected with the hanging ring 325. The locking wire 30 and the hanging ring 325 are connected by metal sleeve riveting. The locking wire 30 only passes through half of the sleeve 324 and only compresses half of the sleeve 324. The other half of the sleeve 324 is used to pass the second limiting wire 140. The second limiting wire 140 passes through the hanging ring 325 and the connecting rope 120 and then passes into the sleeve 324 to realize the connection between the connecting rope 120 and the locking wire 30.

[0105] Embodiment seven:

[0106] In this embodiment, the technical features of the mitral valve ring shrinkage system are the same as those of the mitral valve ring shrinkage system in embodiment four. The difference lies in that, in this embodiment, referring to Figure 14 and Figure 15, the locking rope mounting member 32 is a cylindrical structure with a diameter larger than that of the locking wire 30, and the outer periphery of the locking rope mounting member 32 is provided with a notch 326, and the middle part of the connecting rope 120 is clamped in the notch 326; the gap between the outer diameter of the locking rope mounting member 32 and the inner diameter of the push rod 91 is smaller than the wire diameter of the connecting rope 120, and the push rod 91 is sleeved outside the notch 326 so that the connecting rope 120 cannot be separated from the notch 326, and the connecting rope 120 can be separated from the notch 326 after the push rod 91 is separated. In this embodiment, the radial extrusion of the connecting rope 120 by the push rod 91 makes the connecting rope 120 unable to be separated from the notch 326, and when the push rod 91 is withdrawn, the connecting rope 120 is pulled from the conveying handle 50, and the connecting rope 120 can be separated. When the connecting rope 120 receives the pulling force towards the proximal end, the connecting rope 120 is blocked in the notch 326 by the gap between the push rod 91 and the locking rope mounting member 32, and the connecting rope 120 cannot be separated and will move backward together with the locking rope mounting member 32. When the locking rope mounting member 32 is to be separated, the push rod 91 is only needed to be withdrawn, and the connecting rope 120 is separated along the notch 326.

[0107] Similarly, in one embodiment, in order to make the middle part of the connecting rope 120 smoothly clamped into the notch 326 and quickly separated from the notch 326, the above-mentioned notch 326 is provided with a second guide surface 327, the second guide surface 327 is arranged on the inner wall of the notch 326 close to the conveying handle 50, and the second guide surface 327 is arranged obliquely, thereby facilitating the sliding of the connecting rope 120.

[0108] The above is only a specific embodiment of the present application, but the protection scope of the present application is not limited thereto, and any person skilled in the art can easily think of changes or replacements within the technical range disclosed in the present application, which should be covered within the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A mitral annuloplasty system, characterized by, The system comprises a proximal anchor, a distal anchor, a push rod, a protective sleeve and a delivery handle; the proximal anchor is used to anchor in the human body, and the proximal end of the proximal anchor is provided with a proximal anchor connector; the distal anchor is used to anchor in the human body, and the proximal end of the distal anchor is provided with a distal anchor connector; the push rod is flexible at least in the part of the human body, and the proximal end of the push rod is connected with the delivery handle, and the distal end of the push rod is provided with a push rod connector; the push rod connector and the proximal anchor connector can be buckled with each other; the protective sleeve is flexible, and the proximal end of the protective sleeve is connected with the delivery handle; the distal end of the protective sleeve can be sleeved on the connection between the push rod connector and the proximal anchor connector, and the push rod connector and the proximal anchor connector are limited to prevent the push rod connector and the proximal anchor connector from loosening; and after the protective sleeve is removed, the push rod connector can be separated from the proximal anchor connector under the elastic action of the push rod; the proximal end of the proximal anchor is fixed with a lock structure, the lock structure is provided with an unlocking rope, the delivery handle is provided with a lock control element, the unlocking rope is connected to the lock control element, and the unlocking rope is used to control the opening and closing of the lock structure; when the lock structure is in the closed state, the position of the distal anchor cannot be adjusted; when the lock structure is in the open state, the proximal anchor and the distal anchor slide relative to each other.

2. The mitral annuloplasty system of claim 1, wherein, The push rod connector and the proximal anchor connector are buckled with each other in the direction perpendicular to the axial direction of the push rod.

3. The mitral annuloplasty system of claim 1, wherein, The push rod connector and the proximal anchor connector are both S-shaped in the axial cross section, and the overall outer surface of the push rod connector and the proximal anchor connector after being buckled with each other in the radial direction is cylindrical.

4. The mitral annuloplasty system of claim 1, wherein, The proximal anchor connector is provided with at least two first clamping grooves on the outer periphery; The push rod connector comprises a first body part connected with the push rod and at least two first elastic petals provided on the end of the first body part away from the push rod; At least two first elastic petals are buckled in at least two first clamping grooves under the limiting action of the protective sleeve, and at least two first elastic petals can be ejected from at least two first clamping grooves after the protective sleeve is removed.

5. The mitral annuloplasty system of claim 1, wherein, The system further comprises a lock wire and a push element; the push element and the lock wire are both flexible elements, the distal end of the lock wire is fixed to the proximal end of the distal anchor, the lock wire passes through the proximal anchor, the proximal end of the lock wire is detachably connected with the distal end of the push element, and the proximal end of the push element is connected with the delivery handle; The push rod is sleeved outside the push element and the lock wire; the push element can be separated from the lock wire after the push rod is removed or under the driving of the delivery handle.

6. The mitral annuloplasty system of claim 5, wherein, The proximal end of the lock wire is provided with a lock wire connector, the push element is a core wire, the distal end of the core wire is provided with a core wire connector, and the core wire connector and the lock wire connector are buckled with each other. The push rod is sleeved outside the core wire connector and the locking wire connector, the push rod limits the core wire connector and the locking wire connector to keep the core wire connector and the locking wire connector from being buckled to each other, and the core wire connector and the locking wire connector can be separated from each other under the elasticity of the core wire after the push rod is removed.

7. The mitral annuloplasty system of claim 6, wherein, The core wire connector and the locking wire connector are solid structures with an S-shaped axial cross section, and the overall outer surface of the core wire connector and the locking wire connector after being buckled to each other in the radial direction is cylindrical.

8. The mitral annuloplasty system of claim 6, wherein, The locking wire connector is provided with at least two second clamping grooves on the outer periphery. The core wire connector comprises a second body part connected to the core wire and at least two second elastic petals arranged at the end of the second body part away from the core wire. At least two second elastic petals are buckled in at least two second clamping grooves under the limiting action of the push rod, and at least two second elastic petals can be ejected from at least two second clamping grooves after the push rod is removed.

9. The mitral annuloplasty system of any of claims 6 to 8, wherein, The inner diameter of the proximal end anchor connector is greater than the outer diameter of the locking wire connector.

10. The mitral annuloplasty system of claim 5, wherein, The push member is a connecting rope, the proximal end of the locking wire is provided with a locking rope mounting part, the middle part of the connecting rope passes through the locking rope mounting part, and the two ends of the connecting rope are connected to the delivery handle respectively.

11. The mitral annuloplasty system of claim 10, wherein, The locking rope mounting part is a ring structure arranged at the proximal end of the locking wire, and the middle part of the connecting rope passes through the ring structure.

12. The mitral annuloplasty system of claim 10, wherein, The locking rope mounting part is a cylindrical structure with a diameter greater than that of the locking wire, a plug hole is arranged at the proximal end center of the locking rope mounting part, and a clamping hole in communication with the plug hole is arranged on the outer periphery of the locking rope mounting part; the middle part of the connecting rope is embedded in the clamping hole; the mitral annulus reduction system further comprises a first limiting wire, the proximal end of the first limiting wire is connected to the delivery handle, the distal end of the first limiting wire is inserted into the plug hole and passes through the connecting rope at the clamping hole.

13. The mitral annuloplasty system of claim 12, wherein, The inner wall of the clamping hole close to the delivery handle is provided with an inclined first guide surface.

14. The mitral annuloplasty system of claim 10, wherein, The locking rope mounting part comprises a sleeve and a hanging ring, the hanging ring is connected to the proximal end of the locking wire, the sleeve is sleeved at the connection between the locking wire and the hanging ring, and the hanging ring at least partially extends out of the sleeve; the mitral annulus reduction system further comprises a second limiting wire, the middle part of the connecting rope is staggered with the hanging ring, the proximal end of the second limiting wire is connected to the delivery handle, and the distal end of the second limiting wire sequentially passes through the hanging ring and the connecting rope and is inserted into the sleeve.

15. The mitral annuloplasty system of claim 10, wherein, The locking rope mounting part is a cylindrical structure with a diameter greater than that of the locking wire, a notch is arranged on the outer periphery of the locking rope mounting part, and the middle part of the connecting rope is clamped in the notch; the gap between the outer diameter of the locking rope mounting part and the inner diameter of the push rod is smaller than the wire diameter of the connecting rope, the push rod is sleeved outside the notch so that the connecting rope cannot be separated from the notch, and the connecting rope can be separated from the notch after the push rod is removed.

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