Isoquinoline alkaloid compound and preparation method and application thereof
By extracting and being separated from peppercorns and separating three alcoholic alkali compounds, it is confirmed that it is the inhibitor of the KV2.1 channel and the TRESK channel. Sexual suppression and analgesic effects.
CN115477650BActive Publication Date: 2025-01-24SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES +1
Patent Information
- Application Number
- CN202110666488.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2021-06-16
- Publication Date
- 2025-01-24
- Estimated Expiration
- 2041-06-16
AI Technical Summary
Technical Problem
In the prior art, the mechanism of action of the active ingredients in peppercorns is unclear, and there is a lack of active molecules with novel structure, clear mechanism, and specific application types of diseases.
Method used
Extracted and separated from the peppercorns and separated the alcoholic alkali alkali compounds that have not been seen in the literature. And it has a suppressive effect on the TRESK potassium channel.
Benefits of technology
The selective suppression of the IK current and the KV2.1 channel is achieved, significantly inhibiting the electrical excitement of neurons, and showing the TRESK channel inhibitory activity that is stronger than the reported α-hydroxyl flower petechia, which has analgesic activity.
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Figure CN115477650B_ABST
Abstract
The present invention provides an isoquinoline alkaloid compound selected from the compounds shown in the following structural formula, and a preparation method and application thereof. The present invention first confirms that the isoquinoline alkaloid compound is a K Inhibitors of potassium current and background potassium current, especially inhibitors of Kv2.1 channels and TRESK channels, can be used to treat diseases such as stroke, arrhythmia, atrial fibrillation, diabetes, pain, respiratory depression, depression, etc.
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Citation Information
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