A method for magnetic resonance determination of human body fat composition

Abstract

The application discloses a kind of magnetic resonance human body fat composition determination method.Method for the signal amplitude of the proton of interest extracted in the magnetic resonance spectrum measured obtained to human body;The signal amplitude of the proton of interest is corrected, and then the relative concentration and relative concentration ratio of the proton of interest are obtained by processing;According to the relative concentration of the proton of interest, the fatty acid proportion is obtained by processing.The application can non-invasively measure human body fat composition, and can accurately quantify unsaturated fat protons using the data of edited spectrum, effectively avoid spectrum overlap, remove non-fat signals, realize spectrum signal correction, and finally realize accurate determination of fat composition.

Description

Technical Field

[0001] This invention relates to a method for determining and processing human body composition data, specifically, a method for obtaining human fat composition by analyzing and processing data from magnetic resonance editing spectroscopy. Background Technology

[0002] Ectopic fat deposition refers to the abnormal increase of fat in non-adipose tissues, which may occur in cells of the liver, pancreas, skeletal muscle, and cardiac muscle, and is a characteristic of obesity-related metabolic diseases. Studies have shown that fat composition is more relevant to metabolic disorders and cytotoxicity than fat content: saturated fatty acids induce endoplasmic reticulum stress, potentially leading to insulin resistance, cellular inflammation, and other adverse pathways; monounsaturated fatty acids play a protective role, possibly activating pathways for lipid droplet synthesis within cells, preventing excessive accumulation of fatty acids and lipotoxicity; polyunsaturated fatty acids are important components of cell membranes, crucial for maintaining cell membrane fluidity, and long-chain polyunsaturated fatty acids can also act as pro-inflammatory and anti-inflammatory regulators. Therefore, measuring the fat composition in the human body is of great value for studying fat metabolism and the pathological processes of metabolic diseases.

[0003] Most existing magnetic resonance spectroscopy techniques are still limited to measuring the total amount of lipids, and cannot calculate the specific composition of individual fats. Summary of the Invention

[0004] In order to address the problems existing in the background art, the purpose of this invention is to provide a method for obtaining the composition of human fat by analyzing and processing data from magnetic resonance editing spectroscopy.

[0005] This invention, by processing the data of the edited spectra, can eliminate interference from other possible overlapping metabolic peaks, thereby achieving accurate determination of allyl protons and diallyl protons in unsaturated fatty acids. It is a non-invasive method that can accurately determine the composition of unsaturated fatty acid protons.

[0006] To achieve the above objectives, the method provided by the present invention includes the following steps:

[0007] S1. Extract the signal amplitude of the proton of interest from the magnetic resonance spectrum obtained from the human body;

[0008] S2. Correct the signal amplitude of the proton of interest, and then process it to obtain the relative concentration and relative concentration ratio of the proton of interest;

[0009] S3. Substitute the relative concentration of the protons of interest into the model to obtain the fatty acid ratio, and finally use the relative concentration ratio of the protons of interest and the fatty acid ratio as the measurement results.

[0010] The magnetic resonance spectrum is obtained by measuring the human body's organs using a magnetic resonance measuring instrument and spectral editing technology.

[0011] In practice, different auxiliary measurement controllers can be selected or not selected depending on the different organs being measured in the human body, and then combined with the magnetic resonance imaging (MRI) scanner for measurement. The auxiliary measurement controller is used to control the MRI acquisition time.

[0012] Measurement of subcutaneous fat and muscle organs, without auxiliary measurement controller;

[0013] The device measures abdominal fat and abdominal organs such as the liver, spleen, pancreas, and kidneys. The auxiliary measurement controller is a respiratory gating controller.

[0014] The auxiliary measurement controller for measuring cardiac fat is ECG-gated.

[0015] The basic measuring instrument of this invention is a magnetic resonance measuring instrument, which can use magnetic resonance spectral editing technology combined with respiratory gating and electrocardiogram gating to collect proton signals from different organs of the human body.

[0016] The specific steps of S1 are as follows:

[0017] S1.1 Adjust the echo time; the echo time is set to 40 to 60 ms, with 45 ms being the preferred optimal value.

[0018] Echo time refers to the time interval between the initial generation of transverse magnetization and the received signal after the excitation of a radio frequency pulse in a magnetic resonance imaging (MRI) instrument. This invention allows control of the proton signal amplitude by adjusting the echo time. Different protons have different optimal echo times (i.e., the echo time at which the proton signal amplitude reaches its maximum value), influenced by the scalar coupling effect and spin-lattice relaxation effect of specific protons. S1.2, Adjust the spectral editing module in the MRI instrument and set the working mode of the edit pulse;

[0019] In S1.2, the working mode of the editing pulse is specifically set as follows:

[0020] When the magnetic resonance spectrum acquired by the magnetic resonance measuring instrument is an odd number of spectra, the editing pulse is turned off to obtain the edit-off spectrum;

[0021] When the magnetic resonance spectrum acquired by the magnetic resonance meter is an even-numbered spectrum, the editing pulse is activated to obtain the editable spectrum.

[0022] In practice, the order and relationship of opening and closing the editing score can be changed without affecting the result.

[0023] S1.3 Obtain the original data for closing and opening the editing spectrum according to the working mode of the editing pulse, and reconstruct the signal;

[0024] The magnetic resonance spectrum obtained under the condition of closed editing pulse is used as the closed editing spectrum, and the magnetic resonance spectrum obtained under the condition of open editing pulse is used as the open editing spectrum.

[0025] In step S1.3, the edit spectrum is turned off and the edit spectrum is turned on by adjusting the frequency of the edit pulse applied at a fixed chemical shift.

[0026] In the closed editing spectrum, the editing pulse is applied at any chemical shift that does not affect the final editing spectrum result, specifically at a chemical shift of 7 to 9 ppm;

[0027] When the editing spectrum is enabled, the editing pulse is applied at the chemical shift that can affect vinyl protons, specifically at a chemical shift of 5.31 ppm.

[0028] S1.4 Remove spectra contaminated by factors such as breathing artifacts and heartbeat artifacts from the closed and open edit spectra after signal reconstruction;

[0029] S1.5. After removing contamination, the closed editing spectrum and the open editing spectrum are averaged separately to obtain their respective average spectra. The average spectrum of the closed editing spectrum is obtained by subtracting the average spectrum of the open editing spectrum from the average spectrum of the closed editing spectrum.

[0030] S1.6. Quantify diallyl protons and allyl protons in the difference spectrum, and extract the signal amplitude S of diallyl protons in the difference spectrum. 二烯丙基 The signal amplitude S of allyl protons 烯丙基 ;

[0031] S1.7 Quantify the methylene protons in the closed or open edit spectrum, and extract the signal amplitude S of the methylene protons from the closed or open edit spectrum. 亚甲基 .

[0032] The diallyl proton is located at a chemical shift of 2.77 ppm, the allyl proton is located at a chemical shift of 2.03 ppm, and the methylene proton is located at a chemical shift of 1.32 ppm.

[0033] Diallyl protons, allyl protons, and methylene protons were selected as protons of interest.

[0034] The specific steps of S2 are as follows:

[0035] S2.1, Signal amplitude S of diallyl protons for fatty acids in all human organs of the measurement population. 二烯丙基 The signal amplitude S of allyl protons 烯丙基 The signal amplitude S of methylene protons 亚甲基The average signal amplitude of diallyl protons of fatty acids in the measured population was obtained by averaging the values ​​of each proton. The average signal amplitude of allyl protons of fatty acids in the population was measured. and the average signal amplitude of methylene protons in fatty acids in the population.

[0036] S2.2, The average concentration of diallyl protons of fatty acids in the organs of the target population obtained through prior measurement. Average concentration of allyl protons and the average concentration of methylene protons Measurement methods include gas chromatography, thin-layer chromatography, and mass spectrometry for fatty acid measurement. This is combined with the average signal amplitude of diallyl protons of fatty acids in the measured population. Average signal amplitude of allyl protons The average signal amplitude of methylene protons The first and second correction factors α1 and α2 are obtained by processing according to the following formula:

[0037]

[0038] S2.3. Based on the first and second correction factors α1 and α2, the relative concentration C of diallyl protons of fatty acids in the measured organs of the measured population is obtained according to the following formula. 二烯丙基 The relative concentration C of allyl protons 烯丙基 The relative concentration of methylene protons C 亚甲基 The relative concentration of the protons of interest is given by the following formula:

[0039]

[0040] S2.4, The relative concentration C of diallyl protons of fatty acids in the measured organs of the measurement population obtained in step S2.3. 二烯丙基 The relative concentration C of allyl protons 烯丙基 The relative concentration of methylene protons C 亚甲基 Calculate the relative concentration ratio C of the protons of interest. 烯丙基 / C 亚甲基 C 二烯丙基 / C 亚甲基 C 二烯丙基 / C 烯丙基 .

[0041] The specific steps of S3 are as follows:

[0042] S3.1, Based on the relative concentration C of diallyl protons of fatty acids in the measured organs of the measured population obtained in step S2. 二烯丙基Combined with the average chain length of polyunsaturated fatty acids in the organs of the target population obtained through prior measurements The average number of carbon atoms (n1) independent of the diallyl group in polyunsaturated fatty acids is first processed according to the following formula to obtain the relative concentration (C) of polyunsaturated fatty acids in the measured population. 多不饱和脂肪酸 The formula is as follows:

[0043]

[0044] S3.2, Based on the relative concentration C of polyunsaturated fatty acids in the population being measured. 多不饱和脂肪酸 Combined with the relative concentration C of allyl protons of fatty acids in the measured organs of the measurement population obtained in step S2 烯丙基 The average number of allyl protons (n2) in polyunsaturated fatty acids is used to obtain the relative concentration (C) of monounsaturated fatty acids in the measured population, which is then processed according to the following formula. 单不饱和脂肪酸 The formula is as follows:

[0045]

[0046] S3.3, The average chain length of saturated fatty acids in the organs of the target population obtained through prior measurement. Average chain length of monounsaturated fatty acids Average chain length of polyunsaturated fatty acids The average number of carbon atoms (n3) in saturated fatty acids that are independent of methylene groups, combined with the relative concentration (C) of polyunsaturated fatty acids in the population being measured. 多不饱和脂肪酸 The relative concentration C of monounsaturated fatty acids 单不饱和脂肪酸 And the relative concentration C of methylene protons obtained in step S2 亚甲基 The relative concentration C of saturated fatty acids in the measured population was obtained by processing according to the following formula. 饱和脂肪酸 The formula is as follows:

[0047]

[0048] S3.4, Based on the relative concentration C of polyunsaturated fatty acids in the population being measured. 多不饱和脂肪酸 The relative concentration C of monounsaturated fatty acids 单不饱和脂肪酸 The relative concentration of saturated fatty acids C 饱和脂肪酸 The relative total concentration C of fatty acids in the measured population was obtained by processing according to the following formula. 脂肪酸 The formula is as follows:

[0049] C 脂肪酸 =C 多不饱和脂肪酸 +C 单不饱和脂肪酸 +C 饱和脂肪酸

[0050] S3.5, Based on the total relative concentration C of fatty acids in the measured population. 脂肪酸 Combined with the measurement of the relative concentration C of polyunsaturated fatty acids in the population 多不饱和脂肪酸 The relative concentration C of monounsaturated fatty acids 单不饱和脂肪酸 The relative concentration of saturated fatty acids C 饱和脂肪酸 The proportion of polyunsaturated fatty acids (P) in the fatty acids of the measured population was obtained by processing according to the following formula. 多不饱和脂肪酸 The proportion of monounsaturated fatty acids P 单不饱和脂肪酸 The proportion of saturated fatty acids P 饱和脂肪酸 The formula is as follows:

[0051]

[0052] The measurement population described in this invention includes healthy individuals or other populations that can be used as calibration standards. The measurement organs include human adipose tissue (including subcutaneous fat, abdominal fat, and cardiac fat), muscles, and abdominal organs (including the liver, spleen, pancreas, kidneys, etc.).

[0053] This invention combines the measured allyl proton signal and diallyl proton signal with the methylene proton signal, and through modeling, it can accurately determine the proportion of polyunsaturated fatty acids, monounsaturated fatty acids and saturated fatty acids in the total fatty acid content of different parts of the human body.

[0054] The optimal echo time of this invention (45ms is optimal, and 40ms to 60ms can also achieve good results) has been proven by density matrix simulation, oil model experiments and human experiments to maximize the signal amplitude, thereby improving the signal-to-noise ratio when two protons are collected together.

[0055] Specifically, it relates to a novel method for measuring and calculating the composition of human fat using magnetic resonance editing spectroscopy.

[0056] The present invention calculates the relative concentration of protons by correcting the signal amplitude of the proton signal; after obtaining the relative concentration of protons, it is substituted into the model to calculate the fatty acid ratio.

[0057] The innovation of this invention compared with the prior art lies in:

[0058] This invention enables non-invasive measurement of human fat composition. By using data from edited spectra, it can accurately quantify unsaturated fat protons, achieve spectral signal correction, and ultimately realize the accurate determination of fat composition.

[0059] The optimal echo time range set by this invention enables the signal to have the optimal signal-to-noise ratio.

[0060] This invention can effectively avoid spectral overlap and remove non-fat signals (such as water peaks, proteins, etc.), thus enabling accurate calculation of human fat composition. Attached Figure Description

[0061] Figure 1 This is an overall flowchart of the present invention;

[0062] Figure 2 This is a schematic diagram of the proton metabolism peak spectrum of the liver of an obese patient obtained using the edited spectrum technology of this invention (the methylene concentration in the figure is too high, so it is not fully displayed);

[0063] Figure 3 This is a schematic diagram illustrating the differences in liver fatty acid composition between healthy and obese individuals calculated according to the present invention. Figure 3 'a' represents the relative concentration ratio of protons of interest within the liver. Figure 3 b represents the proportion of fatty acids in the liver. Detailed Implementation

[0064] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0065] The following embodiments will help those skilled in the art to further understand the present invention, but do not limit the invention in any way. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention. These all fall within the scope of protection of the present invention.

[0066] This invention uses the liver, an abdominal organ, as an example. Although the liver plays a crucial role in fat metabolism, it is one of the most difficult organs to measure due to respiratory interference, requiring respiratory gating as an auxiliary measurement controller for detection. The implementation schemes for other human organs are largely the same as for the liver.

[0067] like Figure 1 As shown, the specific implementation is as follows:

[0068] S1. Select the measurement population. In this embodiment, healthy people and obese people are selected, and healthy people are used as the calibration standard.

[0069] S2. Select the organ to be measured. In this embodiment, the abdominal organ - liver - is selected.

[0070] S3. Select the auxiliary measurement controller. In this embodiment, respiratory gating is selected as the auxiliary measurement controller, that is, the measurement is performed by combining the edited spectrum with respiratory gating.

[0071] S4. Measure the amplitude of the proton signal of interest in the human liver using spectral editing technology. The steps include:

[0072] S4.1. Since the liver is close to the thoracic cavity, it is easily affected by respiratory artifacts. Therefore, the region of interest should be selected as far away from the thoracic cavity as possible, closer to the lower part of the body, and avoiding intrahepatic blood vessels.

[0073] S4.2 Adjust the echo time to the optimal value of 45ms.

[0074] S4.3. Adjust the editing pulse to obtain a closed editing spectrum in odd-number spectrum off mode and an open editing spectrum in even-number spectrum on mode. In the closed editing spectrum, the editing pulse is applied at 7 ppm. In the open editing spectrum, the editing pulse is applied at 5.31 ppm.

[0075] S4.4 Obtain the original data for editing the spectrum with the editing spectrum turned off and on, and reconstruct the free induction attenuation signal;

[0076] S4.5, Reconstruction of the spectrum contaminated by respiratory artifacts;

[0077] S4.6. After averaging the closed and open editing spectra for removing contamination respectively, subtract the closed editing spectrum from the open editing spectrum to obtain the difference spectrum. Figure 2 The diagram shows the closed editing spectrum, the open editing spectrum, and the differential spectrum of the liver of an obese adult. Allylic protons, diallylic protons, and methylene protons of interest are labeled in the diagram.

[0078] S4.7 Quantify diallyl protons and allyl protons in the differential spectrum to obtain the diallyl proton signal amplitude S. 二烯丙基 and allyl matrix signal amplitude S 烯丙基 ;

[0079] S4.8 Quantify the methylene protons in the edit spectrum with or without editing to obtain the methylene proton signal amplitude S. 亚甲基 ;

[0080] S5. Correct the proton signal amplitude and calculate the relative concentration of the proton of interest and the relative concentration ratio. The steps include:

[0081] S5.1 The relative proportions of fatty acids in the liver can be obtained from existing literature or by measuring a combination of gas chromatography and thin-layer chromatography.

[0082] S5.2. Based on the relative proportions of various fatty acids in the liver, calculate the average concentration of diallyl protons in the liver fat of healthy individuals. The average concentration of allyl protons was 136.80. The value was 226.64, compared to the average concentration of methylene protons. It was 1995.75;

[0083] S5.3. Based on the following formula, substitute the values ​​of liver fat in healthy individuals to obtain the correction factors α1 as 7.74 and α2 as 4.08.

[0084]

[0085] S5.5. Calculate the relative concentration C of diallyl protons of fatty acids in the measured organs of the measured population, according to the following formula, substituting correction factors α1 and α2. 二烯丙基 The relative concentration C of allyl protons 烯丙基 The relative concentration of methylene protons C 亚甲基 :

[0086]

[0087] S5.6 Calculate the ratio C of the relative concentrations of fatty acids of interest in the measured organs of the measured population. 烯丙基 / C 亚甲基 C 二烯丙基 / C 亚甲基 C 二烯丙基 / C 烯丙基 The relative concentration ratios (mean ± standard deviation %) of protons of interest in healthy individuals (n=4) and obese individuals (n=4) are shown in the table below:

[0088]

[0089] S6. Substitute the values ​​into the model to calculate the fatty acid ratio. The steps include:

[0090] S6.1. The average chain length of saturated fatty acids in liver fat of healthy individuals can be obtained from existing literature or through a combination of gas chromatography and thin-layer chromatography. The average chain length of monounsaturated fatty acids is 16.69. The average chain length of polyunsaturated fatty acids is 19.09. The average number of carbon atoms (n1) in polyunsaturated fatty acids that are not related to the diallyl group is 17.19, the average number of allyl atoms (n2) in polyunsaturated fatty acids is 3.28, and the average number of carbon atoms (n3) in saturated fatty acids that are not related to the methylene group is 14.91.

[0091] S6.2 Substitute the components into the following formula in order to calculate the proportion P of polyunsaturated fatty acids in healthy and obese individuals. 多不饱和脂肪酸 The proportion of monounsaturated fatty acids P 单不饱和脂肪酸 The proportion of saturated fatty acids P 饱和脂肪酸 .

[0092]

[0093]

[0094] The calculated fatty acid ratios (mean ± standard deviation %) for healthy individuals (n=4) and obese individuals (n=4) are shown in the table below:

[0095]

[0096] This allows for accurate determination of liver fat composition in both healthy and obese individuals. Figure 3 The statistics show the liver fat composition of healthy individuals (n=4) and obese individuals (n=4), including (a) the relative concentration ratio of protons of interest in the liver and (b) the proportion of fatty acids in the liver.

Claims

1. A method for determining human fat composition using magnetic resonance imaging, characterized in that: The method includes: S1. Extract the signal amplitude of the proton of interest from the magnetic resonance spectrum obtained from the human body; S2. Correct the signal amplitude of the proton of interest, and then process it to obtain the relative concentration and relative concentration ratio of the proton of interest; S3. Obtain the fatty acid ratio by processing the relative concentration of the protons of interest; The specific steps of S2 are as follows: S2.1 Signal amplitude of diallyl protons for fatty acids in all human subjects in the population. Signal amplitude of allyl protons and the signal amplitude of methylene protons The average signal amplitude of diallyl protons of fatty acids in the measured population was obtained by averaging the values ​​of each proton. Measure the average signal amplitude of allyl protons of fatty acids in the population. and the average signal amplitude of methylene protons in fatty acids in the population. ; S2.2, Based on the previously known average concentration of diallyl protons of fatty acids in the measuring organs of the target population. Average concentration of allyl protons and the average concentration of methylene protons Combined with the average signal amplitude of diallyl protons of fatty acids in the population, Average signal amplitude of allyl protons The average signal amplitude of methylene protons The first and second correction factors are obtained by first processing according to the following formula. , The formula is as follows: ； S2.3, Based on the first and second correction factors , The relative concentrations of diallyl protons of fatty acids in the measured organs of the measured population were obtained by processing according to the following formula. Relative concentration of allyl protons The relative concentration of methylene protons The relative concentration of the protons of interest is given by the following formula: ； S2.

4. The relative concentration of diallyl protons of fatty acids in the organs of the measurement population obtained in step S2.

3. Relative concentration of allyl protons The relative concentration of methylene protons Calculate the relative concentration ratio of the protons of interest. , , .

2. The method for determining human fat composition by magnetic resonance imaging as described in claim 1, characterized in that: The specific steps of S1 are as follows: S1.1 Adjust the echo time; S1.2 Adjust the editing spectrum module in the magnetic resonance measuring instrument and set the working mode of the editing pulse; S1.3 Obtain the original data for closing and opening the editing spectrum according to the working mode of the editing pulse, and reconstruct the signal; S1.4 Remove the spectrum contaminated by breathing artifacts and heartbeat artifacts from the closed and open edit spectra after signal reconstruction; S1.

5. After removing contamination, the closed editing spectrum and the open editing spectrum are averaged separately to obtain their respective average spectra. The average spectrum of the closed editing spectrum is obtained by subtracting the average spectrum of the open editing spectrum from the average spectrum of the closed editing spectrum. S1.6 Extracting the signal amplitude of diallyl protons from the differential spectrum and the signal amplitude of allyl protons ; S1.7 Extract the signal amplitude of methylene protons from the edit spectrum with or without editing. .

3. The method for determining human fat composition by magnetic resonance imaging as described in claim 2, characterized in that: In S1.2, the working mode of the editing pulse is specifically set as follows: When the magnetic resonance spectrum acquired by the magnetic resonance measuring instrument is an odd number of spectra, the editing pulse is turned off to obtain the edit-off spectrum; When the magnetic resonance spectrum acquired by the magnetic resonance measuring instrument is an even number, the editing pulse is activated to obtain the editable spectrum.

4. The method for determining human fat composition by magnetic resonance imaging as described in claim 2, characterized in that: In step S1.3, the edit spectrum is turned off and the edit spectrum is turned on by adjusting the frequency of the edit pulse applied at a fixed chemical shift. In the closed editing spectrum, the editing pulse is applied at a chemical shift of 7 to 9 ppm; When editing the spectrum is enabled, the editing pulse is applied at a chemical shift of 5.31 ppm.

5. The method for determining human fat composition by magnetic resonance imaging as described in claim 1, characterized in that: The specific steps of S3 are as follows: S3.1, Based on the relative concentration of diallyl protons of fatty acids in the measured organs of the measured population obtained in step S2. Combined with the previously known average chain length of polyunsaturated fatty acids in the organs of the target population The average number of carbon atoms (n1) unrelated to the diallyl group in the polyunsaturated fatty acids is used to obtain the relative concentration of polyunsaturated fatty acids in the measured population, calculated using the following formula. The formula is as follows: ； S3.2, Based on the relative concentration of polyunsaturated fatty acids in the population being measured. Combined with the relative concentrations of allyl protons of fatty acids in the organs measured within the measurement population obtained in step S2 The average number of allyl protons (n2) in polyunsaturated fatty acids is used to obtain the relative concentration of monounsaturated fatty acids in the measured population, calculated using the following formula. The formula is as follows: ； S3.3, Based on the previously known average chain length of saturated fatty acids in the organs of the target population. The average chain length of monounsaturated fatty acids Average chain length of polyunsaturated fatty acids The average number of carbon atoms (n3) in saturated fatty acids that are independent of the methylene group, combined with the relative concentration of polyunsaturated fatty acids in the population, is used to determine the composition of the fatty acids. Relative concentration of monounsaturated fatty acids and the relative concentration of methylene protons obtained in step S2 The relative concentration of saturated fatty acids in the measured population was obtained by processing according to the following formula. The formula is as follows: ； S3.

4. Based on the relative concentration of polyunsaturated fatty acids in the population being measured. Relative concentration of monounsaturated fatty acids Relative concentration of saturated fatty acids The relative concentration of fatty acids in the measured population was obtained using the following formula. The formula is as follows: ； S3.

5. Based on the total relative concentration of fatty acids in the population being measured. Combined with the measurement of the relative concentration of polyunsaturated fatty acids in the population Relative concentration of monounsaturated fatty acids Relative concentration of saturated fatty acids The proportion of polyunsaturated fatty acids in the fatty acids of the measured population was obtained by processing according to the following formula. The proportion of monounsaturated fatty acids and the proportion of saturated fatty acids The formula is as follows: 。 6. An electronic device, characterized in that: It includes a memory and a processor, as well as computer instructions stored in the memory and running on the processor, which, when executed by the processor, perform the steps of the method according to any one of claims 1-5.

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