The structure of the analytical device's entry and exit chambers, the analytical device itself, and the analytical system.

Abstract

This invention provides an in-and-out compartment structure for an analytical device, an analytical device, and an analytical system. The in-and-out compartment structure is used to transport the loading section of the analytical device, which carries a detection chip, to achieve the entry or exit of the loading section. The in-and-out compartment structure includes a supporting body, a guide support assembly, and a compartment door opening / closing assembly. The supporting body carries the loading section. The guide support assembly is disposed on a base plate inside the compartment of the analytical device to support the supporting body, and is movably connected to the supporting body so that the supporting body can move in the direction of entry or exit. The compartment door opening / closing assembly is disposed on the base plate and located on the side of the supporting body away from the compartment door. It applies a pushing force towards the exit direction to the supporting body when it is subjected to a pressing force, moving the supporting body to the open position, and locking the supporting body in the closed position when subjected to another pressing force.

Description

Technical Field

[0001] Embodiments of this disclosure relate to the inlet / outlet structure of an analytical device, an analytical device, and an analytical system. Background Technology

[0002] Biochips are a chip technology that transfers the processing and analysis of biological information to a biological substrate, featuring micro-dose, miniaturization, automation, and high throughput. Based on the biomolecules on the solid phase of the chip surface, biochips can be divided into gene chips, protein chips, microfluidic chips, and organ-on-a-chip, etc., and have been widely used in medical diagnosis, precision medicine, and public health. Summary of the Invention

[0003] At least one embodiment of this disclosure provides an in-and-out compartment structure for an analytical device, used to transport a loading section of the analytical device for carrying a detection chip, so as to realize the entry or exit of the loading section. The in-and-out compartment structure includes a supporting body, a guide support assembly, and a compartment door opening and closing assembly, wherein the supporting body is used to carry the loading section.

[0004] The guide support assembly is disposed on the bottom plate inside the chamber of the analysis device to support the carrier body, and the guide support assembly is movably connected to the carrier body so that the carrier body can move in the direction of entering or exiting the chamber.

[0005] The door switch assembly is disposed on the base plate and located on the side of the support body away from the door. It is used to apply a pushing force towards the exit direction to the support body when the support body is subjected to a pressing force, so as to move the support body to the open position, and lock the support body in the closed position when it is subjected to a pressing force again.

[0006] Optionally, the guide support assembly includes a support component, a guide rail, and a slider, wherein the support component is disposed on the base plate to support the load-bearing body;

[0007] One of the guide rail and the slider is disposed on the surface of the support member opposite to the base plate, and the other of the guide rail and the slider is disposed on the surface of the bearing body facing the base plate; and the guide rail and the slider are slidably connected in the direction of entering or exiting the compartment.

[0008] Optionally, the support component includes a first support sub-component, a second support sub-component, and at least one roller, wherein the first support sub-component is fixedly connected to the base plate, and one of the guide rail and the slider is disposed on the surface of the first support sub-component opposite to the base plate;

[0009] The second support sub-component is fixedly connected to the surface of the supporting body facing the bottom plate, and is close to the end of the supporting body away from the compartment door;

[0010] The roller is mounted on the second support sub-component and makes rolling contact with the base plate.

[0011] Optionally, the door switch assembly includes a fixed bracket, a limiting structure disposed on the fixed bracket, and an elastic component connected to the limiting structure, wherein the fixed bracket is fixed to the base plate and located on the side of the supporting body away from the door;

[0012] The limiting structure is connected to the elastic component and detachably connected to the carrying body. The limiting structure is configured such that when the carrying body in the closed position moves to the trigger position along the inlet direction under the pressing force, the limiting structure releases the locking of the carrying body and applies a thrust towards the outlet direction to the carrying body under the elastic force of the elastic component, so that the carrying body moves to the open position; when the carrying body in the open position moves to the trigger position along the inlet direction under the pressing force, the limiting structure locks the carrying body in the closed position.

[0013] Optionally, the limiting structure includes a housing, a limiting component, and a locking component, wherein the housing has an opening on the side opposite to the bearing body, and a guide limiting portion is provided on the inner surface of the housing; the elastic component is located in the internal space of the housing, and the fixed end of the elastic component is fixedly connected to the housing, and the telescopic end of the elastic component is fixedly connected to the locking component.

[0014] The limiting component is rotatably connected to the telescopic end of the elastic component, and the limiting component is configured such that when the telescopic end of the elastic component extends or retracts in a direction approaching or away from the opening, it can drive the limiting component to slide along the guide limiting portion, so that the limiting component can sequentially pass through a first position, a second position, and a third position from an initial position. Specifically, when the limiting component is in the initial position, the supporting body is in the open position; when the limiting component is in the first position or the third position, the supporting body is in the trigger position; and when the limiting component is in the second position, the limiting component and the guide limiting portion are relatively fixed, and the supporting body is in the closed position.

[0015] The locking component can be moved into or out of the interior space of the housing through the opening, and the locking component is detachably connected to the carrier body. It is configured such that: during the process of the carrier body moving from the open position to the closed position, the locking component remains connected to the carrier body to lock the carrier body in the closed position; during the process of the carrier body moving from the closed position to the open position, the locking component separates from the carrier body to allow the carrier body to move independently to the open position.

[0016] Optionally, the locking component includes one of a magnet and an iron block, and the other of the magnet and the iron block is disposed on the surface of the supporting body opposite to the locking component.

[0017] Optionally, a first latch is provided on the surface of the supporting body opposite to the locking component. The locking component includes a second latch. When the second latch is outside the internal space of the housing, it is in its original state of being separated from the first latch. During the process of the second latch moving into the internal space of the housing through the opening, it undergoes elastic deformation under the compression of the housing so as to engage with the first latch.

[0018] Optionally, the upper surface of the supporting body is provided with a receiving groove for accommodating the loading part; and a plurality of mounting holes are provided on the bottom surface of the receiving groove for detachably connecting to the loading part by means of fasteners.

[0019] Optionally, the surface of the supporting body that faces away from the interior of the compartment is flush with the outer surface of the compartment when the supporting body is in the closed position.

[0020] As another technical solution, this disclosure also provides an analysis device, including: a loading unit, an inlet / outlet unit, and a signal detection unit, wherein,

[0021] The loading section is used to carry the detection chip;

[0022] The loading / unloading section adopts the loading / unloading structure provided in the embodiments of this disclosure and is used to transport the loading section so as to realize the loading section entering or leaving the warehouse;

[0023] The signal detection unit includes an optical sensor, wherein the optical sensor is configured to receive light from the detection chip and perform detection based on the light when the in-and-out compartment is in the closed position.

[0024] Optionally, the loading unit includes a loading plate, and a chip groove is provided on the first plate surface of the loading plate for accommodating the detection chip; and the shape and size of the chip groove are adapted to the shape and size of the detection chip.

[0025] A pick-and-place groove is also provided on the first plate surface, and the pick-and-place groove is connected to the chip groove.

[0026] Optionally, there are two pick-and-place grooves, which are symmetrically arranged on two opposite sides of the chip groove.

[0027] Optionally, an optical detection centering area is provided on the bottom surface of the chip recess, which is directly opposite the signal detection unit and located at the center of the image.

[0028] Optionally, the optical sensor is an image sensor configured to acquire optical images of the detection chip for analysis.

[0029] Optionally, the image sensor is a charge-coupled device (CCD).

[0030] Optionally, the signal detection unit further includes:

[0031] A light source configured to provide light to illuminate the detection chip during use;

[0032] The light transmission unit is configured to transmit light provided by the light source to the detection chip and light emitted by the detection chip to the optical sensor during use; and

[0033] A bracket is provided for fixing and supporting the light source and the light transmission unit. A focal length adjustment structure is also provided on the bracket. The focal length adjustment structure is configured to adjust the distance between the light transmission unit and the detection chip so that the detection chip is located at the focal point of the light transmission unit. Furthermore, the focal length adjustment structure has a focal length adjustment knob and a knob extension connected to the focal length adjustment knob. The knob extension extends to the side close to the light transmission unit to facilitate manual adjustment.

[0034] Optionally, the analysis device further includes a controller configured to be signal-connected to the optical sensor to analyze the light from the detection chip.

[0035] Optionally, the analysis device may further include at least one of the following groups: a display screen, a touch sensor, a power interface, and a data transmission interface.

[0036] Optionally, the analysis device is applied to a microfluidic chip.

[0037] As another technical solution, this disclosure also provides an analysis system, including:

[0038] The analytical apparatus described above is provided in the embodiments of this disclosure; and

[0039] The detection chip. Attached Figure Description

[0040] To more clearly illustrate the technical solutions of the embodiments of this disclosure, the accompanying drawings of the embodiments will be briefly described below. Obviously, the drawings described below only relate to some embodiments of this disclosure and are not intended to limit this disclosure.

[0041] Figure 1A This is a structural diagram of a detection chip provided according to at least one embodiment of the present disclosure;

[0042] Figure 1B This is a structural diagram of the loading section provided according to at least one embodiment of the present disclosure;

[0043] Figure 2 This is a structural diagram of the inlet / outlet structure of an analysis apparatus provided according to at least one embodiment of the present disclosure;

[0044] Figure 3A This is a structural diagram of a guide support assembly and a door opening and closing assembly provided according to at least one embodiment of the present disclosure;

[0045] Figure 3B This is a bottom structure diagram of a support body provided according to at least one embodiment of the present disclosure;

[0046] Figure 4A This is another structural diagram of the inlet / outlet structure of the analysis device provided according to at least one embodiment of the present disclosure;

[0047] Figure 4B This is another bottom structure diagram of the support body provided according to at least one embodiment of the present disclosure;

[0048] Figure 5A This is a cross-sectional view of a door opening and closing assembly provided according to at least one embodiment of the present disclosure;

[0049] Figure 5B This is a structural diagram of a guide limiting portion provided according to at least one embodiment of the present disclosure;

[0050] Figure 5C This is a motion trajectory diagram of a limiting component provided according to at least one embodiment of the present disclosure;

[0051] Figure 5D This is a motion diagram of the door opening and closing assembly and the supporting body provided according to at least one embodiment of the present disclosure;

[0052] Figure 6A This is a cross-sectional view of another door opening and closing assembly provided according to at least one embodiment of the present disclosure in one state;

[0053] Figure 6B This is a cross-sectional view of another door opening and closing assembly provided according to at least one embodiment of the present disclosure in another state;

[0054] Figure 7 This is a schematic block diagram of an analysis apparatus provided according to at least one embodiment of the present disclosure;

[0055] Figure 8 This is a schematic block diagram of a signal detection unit provided according to at least one embodiment of the present disclosure;

[0056] Figure 9 This is another schematic diagram of an analysis apparatus provided according to at least one embodiment of the present disclosure;

[0057] Figure 10A This is a side view of a signal detection unit according to at least one embodiment of the present disclosure;

[0058] Figure 10B This is a view of the signal detection unit according to at least one embodiment of the present disclosure from another side;

[0059] Figure 11 This is an internal assembly drawing of an analytical apparatus provided according to at least one embodiment of the present disclosure;

[0060] Figure 12A This is an external assembly drawing of an analytical apparatus provided according to at least one embodiment of the present disclosure;

[0061] Figure 12B This is another external assembly drawing of the analysis apparatus provided according to at least one embodiment of the present disclosure;

[0062] Figure 13 This is a schematic diagram of an analysis system provided according to at least one embodiment of the present disclosure. Detailed Implementation

[0063] To make the objectives, technical solutions, and advantages of the embodiments of this disclosure clearer, the technical solutions of the embodiments of this disclosure will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this disclosure. All other embodiments obtained by those skilled in the art based on the described embodiments of this disclosure without creative effort are within the scope of protection of this disclosure.

[0064] Unless otherwise defined, the technical or scientific terms used in this disclosure shall have the ordinary meaning understood by one of ordinary skill in the art to which this disclosure pertains. The terms “first,” “second,” and similar terms used in this disclosure do not indicate any order, quantity, or importance, but are merely used to distinguish different components. Terms such as “comprising” or “including” mean that the element or object preceding the word encompasses the elements or objects listed following the word and their equivalents, without excluding other elements or objects. Terms such as “connected” or “linked” are not limited to physical or mechanical connections, but can include electrical connections, whether direct or indirect. Terms such as “upper,” “lower,” “left,” and “right” are used only to indicate relative positional relationships, and these relative positional relationships may change accordingly when the absolute position of the described objects changes.

[0065] To keep the following description of the embodiments of this disclosure clear and concise, detailed descriptions of known functions and known components are omitted.

[0066] Some existing biochip reader products typically require multiple supporting devices to obtain analysis results, which leads to inconvenience, long detection time, low degree of automation, high detection cost, many operation steps, and the risk of reagent contamination.

[0067] At least one embodiment of this disclosure provides an inlet / outlet structure for an analytical device, an analytical device, and an analytical system. The analytical device of this embodiment integrates a loading unit, an inlet / outlet unit, and a signal detection unit, enabling the detection of the detection chip with a single device. This reduces the number of required auxiliary equipment, simplifies operation steps, shortens detection time, increases automation, lowers detection costs, and reduces the risk of reagent contamination. Furthermore, by using the aforementioned inlet / outlet structure to transport the loading unit carrying the detection chip, the loading unit can be moved in or out of the device. This simplifies the installation process of the loading unit, automates inlet / outlet operations, and improves operational portability, thereby increasing work efficiency.

[0068] Detection chips are a chip technology that transfers the process of processing and analyzing biological information to a biological substrate. Based on the biomolecules solidified on the chip surface, biochips can be divided into gene chips, protein chips, microfluidic chips, and organ-on-a-chip, etc. At least one embodiment of this disclosure provides an analysis device and analysis system that can receive light from the detection chip using a signal detection unit and perform detection based on the light, and can analyze the light from the detection chip. It has a fast detection speed and is easy to operate, and has great application prospects in scenarios such as ambulances, emergency centers, and disaster sites.

[0069] At least one embodiment of this disclosure provides an analytical device and system applicable to biochips such as gene chips, protein chips, microfluidic chips, and organ-on-a-chip. Taking microfluidic chips as an example, Figure 1A This is a structural diagram of a detection chip provided according to at least one embodiment of the present disclosure. Figure 1A As shown, the microfluidic chip includes a substrate 800, which includes an inlet 801 and a reaction region 802 located downstream of the inlet 801. The reaction region 802 includes at least one groove, and the orthographic projection of each groove onto the substrate 800 is an axisymmetric pattern. The width of the axisymmetric pattern in a first direction D1 is not less than the width of the axisymmetric pattern in a second direction D2, where the first direction D1 is perpendicular to the second direction D2.

[0070] It should be noted that in this disclosure, the first direction D1 refers to the direction of liquid flow when passing through the reaction zone during the use of the microfluidic chip, and the second direction D2 refers to the direction perpendicular to the liquid flow direction in the reaction zone. In some embodiments, such as Figure 1A As shown, the reaction region includes a first groove 1021 and a second groove 1022. The orthographic projection of the first groove 1021 onto the substrate 800 is a first axisymmetric pattern, and the first axisymmetric pattern has a first axis of symmetry ( Figure 1A Along the first direction D1), the orthographic projection of the second groove 1022 on the substrate is a second axisymmetric pattern, and the second axisymmetric pattern has a second axis of symmetry ( Figure 1A (Also along the first direction D1). It should be noted that the first axis of symmetry and the second axis of symmetry being in the same direction is merely exemplary; in some embodiments, there may be an angle between the first axis of symmetry and the second axis of symmetry. More specifically, for embodiments where the reaction region includes more grooves, the angles between the axes of symmetry of the various axisymmetric figures may be the same or different.

[0071] By designing a long and narrow reaction zone, the liquid can have a smaller forward surface, which helps to reduce air bubbles, facilitates more uniform sample passage through the reaction zone, and improves detection results.

[0072] In some embodiments, the reaction region may include at least two grooves, the orthographic projection shapes of which may be different on the substrate 800. For example, as... Figure 1AThe diagram schematically illustrates a first groove 1021 and a second groove 1022, the shapes of which may differ. The orthographic projection of the first groove 1021 onto the substrate is a first axisymmetric shape, and the orthographic projection of the second groove 1022 onto the substrate is a second axisymmetric shape. In some embodiments, the width of the first axisymmetric shape in the first direction D1 is smaller than the width of the second axisymmetric shape in the first direction D1. In some embodiments, the width of the first axisymmetric shape in the second direction D2 is greater than the width of the second axisymmetric shape in the second direction D2.

[0073] In some embodiments of this disclosure, the reaction region may include at least two grooves, the at least two grooves having the same orthographic projection shape on the substrate.

[0074] In some embodiments of this disclosure, the axisymmetric shape may include polygons, circles, spindle shapes, etc. Those skilled in the art can reasonably design the shape and size of the reaction zone according to actual needs, and this disclosure does not make specific limitations in this regard. Figure 1A The example shows a hexagonal reaction zone, which can effectively reduce the bubbles generated during liquid flow and make the reactant flow more uniform.

[0075] The substrate 800 may further include a mixing region located downstream of the injection port 101, such as a first mixing region 103 located upstream of the first groove 1021 and a second mixing region 104 located upstream of the second groove 1022, for example... Figure 1A As shown, the mixing zone may include a serpentine flow channel. A serpentine flow channel allows for a more compact channel design, providing longer channels within a limited chip area, resulting in more thorough and uniform mixing of the reactants.

[0076] In some embodiments of this disclosure, such as Figure 1A As shown, the flow channel length of the second mixing zone 104 is greater than that of the first mixing zone 103. This allows the sample to react more fully in the first groove 1021 of the reaction zone 102 before entering the second groove 1022 of the reaction zone 102 for subsequent reactions.

[0077] In some embodiments of this disclosure, such as Figure 1A As shown, the substrate 800 may further include a waste liquid area 105 and a sample outlet 106, wherein the waste liquid area 105 is located downstream of the reaction area 102 and upstream of the sample outlet 106. After the reaction in the microfluidic chip is completed, buffer solution can be pumped in from the sample inlet to wash away unreacted antibodies. The waste liquid area is used to collect waste liquid from washing the reaction area, avoiding any impact on the detection results. For example, the waste liquid area can be as follows: Figure 1A The rectangular shape shown.

[0078] It should be understood that the embodiments of this disclosure are illustrated by taking the reaction region of a microfluidic chip as an example, which includes two grooves. Those skilled in the art can design the number of grooves in the reaction region and the number of openings in the second substrate according to actual needs. This disclosure does not limit this.

[0079] In some embodiments of this disclosure, the orthographic projection of the reaction zone on the substrate may lie within the orthographic projection of the opening on the substrate. For example, the orthographic projection of the first groove of the reaction zone on the substrate may lie within the orthographic projection of the first opening on the substrate, and the orthographic projection of the second groove of the reaction zone on the substrate may lie within the orthographic projection of the second opening on the substrate. This allows the substance to be detected flowing through the reaction zone to fully contact the substance on the cover plate. In some embodiments, the orthographic projection of the opening on the substrate may lie within the orthographic projection of the reaction zone on the substrate. For example, the orthographic projection of the first opening on the substrate may lie within the orthographic projection of the first groove of the reaction zone on the substrate, and the orthographic projection of the second opening on the substrate may lie within the orthographic projection of the second groove of the reaction zone on the substrate. This allows the substance on the cover plate to fully contact the substance to be detected flowing through the reaction zone. Those skilled in the art can reasonably design the shape and size of the reaction zone and the opening according to actual needs. Optionally, the widths of the orthographic projections of the reaction zone and the opening on the substrate in the second direction may be equal, and the two edges of the orthographic projection of the reaction zone on the substrate perpendicular to the second direction coincide with the two edges of the orthographic projection of the opening on the substrate perpendicular to the second direction. Alternatively, the orthographic projection of the reaction zone on the substrate and the orthographic projection of the opening on the substrate can completely coincide.

[0080] In some embodiments of this disclosure, the substrate may be made of polymer materials, such as polymethyl methacrylate (PMMA), polydimethylsiloxane, polycarbonate, polyethylene terephthalate, cyclic olefin copolymers, etc. Polymer materials are easy to process and make it easier to fabricate the flow channels and various functional regions of the microfluidic chip.

[0081] It should be understood that the shape and proportions of the reaction region in the embodiments of this disclosure are exemplary, and those skilled in the art can reasonably design the length and width ratio of the reaction region according to the actual chip size and the application requirements.

[0082] Taking a microfluidic chip used for immunofluorescence detection as an example, the substrate can be made of polymer materials, such as PMMA, and the cover plate can be made of glass. In this case, antibodies can be grafted onto the modified glass and then lyophilized for storage. Alternatively, the cover plate can be attached to the second substrate after the first and second substrates are thermo-bonded. In this way, antibody lyophilization and substrate thermo-bonding can be performed separately, avoiding the influence of thermo-bonding on antibody grafting and storage.

[0083] Referring to Figure 1, the reaction flow of the microfluidic chip for immunofluorescence detection is illustrated. The sample to be tested enters through the inlet 101, passes through the serpentine first mixing zone 103, and then enters the first groove 1021 of the reaction zone. The sample reacts with the lyophilized fluorescent antibody pre-embedded on the cover plate (not shown) corresponding to the first groove 1021, causing antibody rehydration and specific binding of the antigen and antibody. After passing through the serpentine second mixing zone 104, the antigen and fluorescent antibody in the sample react fully. When this antigen-antibody pair reaches the second groove 1022 of the reaction zone, it reacts with the capture antibody grafted on the cover plate (not shown) corresponding to the second groove 1022, forming a double-antibody sandwich. After the reaction is complete, buffer solution is pumped into the chip through the inlet 101 to rinse the reacted area, washing away any uncaptured fluorescent antibodies. The waste liquid flows into the waste liquid zone 106. The chip is then placed in an analytical device for optical signal detection to determine the antigen content in the sample.

[0084] Figure 1B This is a structural diagram of a loading section provided according to at least one embodiment of the present disclosure. For example... Figure 1B As shown, the loading unit 1 is used in the analysis device to carry the aforementioned detection chip, for example... Figure 1A The microfluidic chip is shown in the figure. The loading section 1 is mounted on the inlet / outlet section of the analysis device, which adopts the inlet / outlet structure provided in at least one embodiment of the present disclosure. Figure 2 This is a structural diagram of the inlet / outlet structure of an analysis apparatus provided according to at least one embodiment of the present disclosure. For example... Figure 2 As shown, the loading / unloading structure is used to transport the loading unit 1 to realize the loading unit 1 entering or exiting the warehouse. The loading / unloading structure includes a supporting body 2, a guide support assembly 4, and a door opening / closing assembly 5. The supporting body 2 is used to support the loading unit 1. The upper surface 2a of the supporting body 2 is provided with a receiving groove for accommodating the loading unit 1; and multiple mounting holes (not shown in the figure) are provided on the bottom surface of the receiving groove for detachable connection with the loading unit 1 by fasteners.

[0085] Specifically, such as Figure 1B As shown, the loading unit 1 includes a loading plate 11, which is, for example, a rectangular plate. A chip recess 12 is provided on the first surface 1a of the loading plate 11 for accommodating the detection chip. The shape and size of the chip recess 12 are adapted to the shape and size of the detection chip, thus both accommodating the detection chip and defining its position on the loading plate 11, ensuring that the detection chip does not deviate from its detection position during movement. For example, the orthographic projection shape of the chip recess 12 on the loading plate 11 adopts a shape similar to... Figure 1AThe microfluidic chip shown is rectangular with the same dimensions. Furthermore, a pick-and-place groove 13 is provided on the first plate surface 1a, which communicates with the chip recess 12. By providing the pick-and-place groove 13, it is easier for a person to grasp the chip, thereby improving the convenience of chip handling. Optionally, the orthographic projection shape of the pick-and-place groove 13 on the mounting plate 11 is, for example, a semi-circle or a semi-ellipse. In addition, the depth of the pick-and-place groove 13 and the chip recess 12 can be the same to facilitate processing.

[0086] In some embodiments of this disclosure, optionally, there are two pick-and-place grooves 13, which are symmetrically arranged on two opposite sides of the chip groove 12. This allows the chip to be held with two fingers, thus enabling a more stable gripping or placement of the chip and preventing the chip from falling or colliding with the loading board 11.

[0087] In some embodiments of this disclosure, a plurality of mounting holes 15 are also provided on the loading plate 11. When the loading plate 11 is placed in the receiving groove of the supporting body 2, each of the plurality of mounting holes 15 is coaxially arranged in a one-to-one correspondence with each mounting hole in the receiving groove, so that the loading plate 11 can be fixed to the supporting body 2 by screws. Optionally, the plurality of mounting holes 15 are distributed at the four corners of the loading plate 11 to ensure that the loading plate 11 is subjected to uniform force.

[0088] In some embodiments of this disclosure, the upper surface 2a of the supporting body 2 is provided with a receiving groove for accommodating the loading plate 11; and a plurality of mounting holes (not shown in the figure) are provided on the bottom surface of the receiving groove for detachably connecting it to the loading plate 11 by fasteners. Optionally, the shape and size of the receiving groove are adapted to the shape and size of the loading plate 11, so that the loading plate 11 can be accommodated and its position on the supporting body 2 can be limited, ensuring that the loading plate 11 will not move during movement. For example, the orthographic projection shape of the receiving groove on the supporting body 2 is a rectangle with the same size as the loading plate.

[0089] like Figure 2 As shown, the guide support assembly 4 is installed on the bottom plate 3 inside the chamber of the analysis device. Figure 2 Only the base plate 3 is shown. The guide support assembly 4 supports the aforementioned load-bearing body 2, and the guide support assembly 4 is movably connected to the load-bearing body 2 so that the load-bearing body 2 can move in the direction of entering or exiting the warehouse. The direction of entering the warehouse is... Figure 2 The X1 direction shown in the diagram; the exit direction is... Figure 2 The X2 direction is shown in the figure.

[0090] The door opening / closing assembly 5 is mounted on the base plate 3 and located on the side of the supporting body 2 furthest from the door (i.e., the front side of the supporting body 2 in the X1 direction). It is used to apply a pushing force towards the supporting body 2 in the exit direction (i.e., the X2 direction) when the supporting body 2 is subjected to a pressing force, thereby moving the supporting body 2 to the open position. Upon being pressed again, it locks the supporting body 2 in the closed position. It should be noted that the side of the supporting body 2 closest to the door is connected to the door, or this side can be directly used as the door.

[0091] By repeatedly pressing the carrying body 2, the carrying body 2 can be moved into and out of the warehouse, thereby automating the entry and exit of the warehouse, improving operational portability, and thus improving work efficiency.

[0092] In some embodiments of this disclosure, optionally, as shown in Figures 3 and 4, the guide support assembly 4 includes a support component 41, a slider 42, and a guide rail 43. The support component 41 is disposed on the base plate 3 to support the load-bearing body 2. For example, the support component 41 adopts a bracket structure. Specifically, this bracket structure consists of a horizontal support plate and two vertical support plates. The two vertical support plates are arranged opposite each other in a direction perpendicular to the inlet direction (i.e., the X1 direction), and their lower ends are fixedly connected to the base plate 3 by fasteners 44. The horizontal support plate is located between the two vertical support plates and is integrally connected to both. This support component 41 can limit the load-bearing body 2 to a certain height above the base plate 3, so as to be compatible with the height of the inlet on the analyzer's chamber for the load-bearing body 2 to enter and exit. That is, the height of the load-bearing body 2 from the base plate 3 after installation on the support component 41 is determined by reasonably designing the height dimensions of the vertical support plates.

[0093] In some embodiments of this disclosure, such as Figure 3A As shown, the slider 42 is disposed on the surface of the support member 41 opposite to the base plate 3 (i.e., the upper surface of the horizontal support plate); as Figure 3B As shown, the guide rail 43 is disposed on the surface 2b of the support body 2 facing the base plate 3, and is slidably connected to the slider 42 in the direction of entering or exiting the compartment (i.e., the X1 direction or the X2 direction). The slider 42 and the guide rail 43 guide the movement direction of the support body 2, thereby improving the stability and accuracy of the movement of the support body 2. The structure of the guide rail 43 can be varied, for example, as... Figure 4BAs shown, the guide rail 43 is a guide channel formed by the intervals between parallel side beams 431 and guide bars 432. The slider 42 is located in this guide channel and can slide along it. Optionally, there are two guide rails 43, spaced apart in a direction perpendicular to X1, to ensure stable support for the load-bearing body 2 and further improve the movement stability of the load-bearing body 2. The number of sliders 42 is the same as the number of guide rails 43, and they are arranged in a one-to-one correspondence.

[0094] It should be noted that in practical applications, the slider 42 can also be set on the surface 2b of the supporting body 2 facing the base plate 3, and the guide rail 43 can be set on the surface of the supporting member 41 away from the base plate 3. In this case, the length of the supporting member 41 in the X1 direction can be appropriately increased.

[0095] To further improve the support stability and movement stability of the load-bearing body 2, optionally, such as Figure 4A and Figure 4B As shown, the aforementioned guide support assembly 4 may further include another support component 41'. Specifically, the support component 41' includes a first support sub-component 411, a second support sub-component 412, and at least one roller 413. The first support sub-component 411 is fixedly connected to the base plate 3, and one of the guide rail 43 and the slider 42 is disposed on the surface of the first support sub-component 411 facing away from the base plate 3. The structure and function of the first support sub-component 411 are the same as described above. Figure 3A The structure and function of the aforementioned support structure are the same, and will not be repeated here. Figure 4B As shown, the second support sub-component 412 is fixedly connected to the surface 2a of the support body 2 facing the base plate 3, and is located near the end of the support body 2 away from the aforementioned door (i.e., the front end of the support body 2 in the X1 direction). A roller 413 is disposed on the second support sub-component 412 and rolls in contact with the base plate 3; that is, the roller 413 can roll on the surface of the base plate 3. Optionally, there can be multiple rollers 413, spaced apart along a direction perpendicular to the X1 direction.

[0096] Since the first support sub-component 411 and the second support sub-component 412 are supported at different positions in the X1 direction on the load-bearing body 2, the movement stability of the load-bearing body 2 can be further improved.

[0097] Please refer to the following: Figure 3A and Figure 5A The door opening and closing assembly 5 includes a fixed bracket 51, a limiting structure 52 disposed on the fixed bracket 51, and an elastic member 53 connected to the limiting structure 52. The fixed bracket 51 is fixed to the base plate 3 and located on the side of the supporting body 2 closest to the interior of the compartment (i.e., the front side of the supporting body 2 in the X1 direction). The structure of the fixed bracket 51 can be... Figure 3A The support component 41 shown uses a similar bracket structure to fix the limiting structure 52 at a certain height above the base plate 3 so as to be compatible with the height of the supporting body 2. That is, the height of the limiting structure 52 from the base plate 3 after installation on the fixed bracket 51 is determined by reasonably designing the height dimensions of the fixed bracket 51.

[0098] like Figure 5A As shown, the limiting structure 52 is connected to the elastic component 53 and is detachably connected to the bearing body 2. The limiting structure 52 is configured such that when the bearing body 2, which is in the closed position, is subjected to a pressing force and moves to the trigger position along the inlet direction (X1 direction), the limiting structure 52 releases the locking of the bearing body 2 and applies a thrust toward the outlet direction (X2 direction) to the bearing body 2 under the elastic force of the elastic component 53, so that the bearing body 2 moves to the aforementioned open position. In other words, before being subjected to a pressing force, the carrier body 2, which is in the closed position, is restricted to that position by the limiting structure 52. When subjected to a pressing force, the carrier body 2 moves from the closed position to the inlet direction (X1 direction) to the trigger position. At this time, the limiting structure 52 releases the lock on the carrier body 2, allowing the carrier body 2 to exit the compartment. Afterward, under the elastic force of the elastic component 53, the limiting structure 52 pushes the carrier body 2 to move along the outlet direction (X2 direction) until the carrier body 2 moves to the aforementioned open position.

[0099] When the bearing body 2, which is in the above-mentioned open position, is moved to the above-mentioned trigger position along the inlet direction (X1 direction) by the pressing force, the limiting structure 52 locks the bearing body 2 in the above-mentioned closed position.

[0100] The aforementioned limiting structure 52 can have various structures, for example, such as Figure 5A As shown, the aforementioned limiting structure 52 includes a housing 521, a limiting component 522, and a locking component 523. The housing 521 has an opening 521a on the side opposite to the supporting body 2 (facing the exit direction (X2 direction)). The elastic component 53 is located within the internal space of the housing 521, with its fixed end fixedly connected to the housing 521 (on the side opposite to the opening 521a), and its telescopic end fixedly connected to the locking component 523. The elastic component 53 can drive the locking component 522 to extend from or retract from the opening 421a into the internal space of the housing 521.

[0101] The limiting member 522 and the aforementioned telescopic end of the elastic member 53 are rotatably connected, and, as Figure 5BAs shown, a guide limiting part 54 is provided on the inner surface of the outer casing 521. The limiting member 522 is configured such that when the telescopic end of the elastic member 53 extends or retracts in the direction approaching or away from the opening 521a (i.e., the X2 direction or the X1 direction), it can drive the limiting member 522 to slide into the guide limiting part 54.

[0102] There are various sliding engagement methods between the limiting component 522 and the guide limiting part 54, for example, Figure 5B As shown, the guide limiting portion 54 includes a first fixed protrusion 541 and a second fixed protrusion 542 spaced apart along the X1 direction on the inner surface of the housing 521 facing its internal space, forming a limiting channel 543 between them. Furthermore, the limiting member 522 includes a rotating rod 522 and a first sliding protrusion 522a and a second sliding protrusion 522b disposed at both ends of the rotating rod 522. The first sliding protrusion 522a is capable of moving along the first fixed protrusion 541... Figure 5B The inclined plane moves as shown, so as to move the second sliding protrusion 522b into the limiting channel 543.

[0103] Specifically Figure 5D In diagram (a), the limiting component 522 is in the initial position, and the supporting body 2 is in the open position B1; when the supporting body 2 is subjected to a pressing force F and moves along the infeed direction (X1 direction) to the trigger position B2, as shown... Figure 5D As shown in Figure (b), the locking component 523 moves along the loading direction (X1 direction) under the pushing action of the supporting body 2, thereby causing the aforementioned telescopic end of the elastic component 53 to retract along the X1 direction, and simultaneously driving the rotating rod 522 to move along the X1 direction. During this process, as shown in Figure (b), Figure 5C As shown, the first sliding protrusion 522a moves along the X1 direction, and when it moves to position A0, the first sliding protrusion 522a moves along the first fixed protrusion 541. Figure 5C The inclined surface shown in the figure slides at an angle, so that the rotating rod 522 drives the second sliding protrusion 522b along the first fixed protrusion 541. Figure 5C The vertical surface shown in the figure slides vertically until the second sliding protrusion 522b reaches the first position A1 corresponding to the first port of the limiting channel 543, and then enters the limiting channel 543 under the torque of the rotating rod 522.

[0104] When the pressing force F is released, as Figure 5D As shown in Figure (c), the elastic member 53 in the compressed state will rebound along the X2 direction, thereby driving the second sliding protrusion 522b to slide along the limiting channel 543 until it moves to the second position A2, as shown in Figure (c). Figure 5CAs shown, at this time, the second sliding protrusion 522b cooperates with the recess in the limiting channel 543 so that the two can be fixed relative to each other, thereby locking the bearing body 2 in the closed position B3.

[0105] like Figure 5D As shown in Figure (d), when the supporting body 2 is subjected to a pressing force F again and moves to the trigger position B2 along the insertion direction (X1 direction), the locking component 523 moves along the insertion direction (X1 direction) under the pushing action of the supporting body 2, so as to drive the aforementioned telescopic end of the elastic component 53 to retract along the X1 direction, and simultaneously drive the rotating rod 522 to move along the X1 direction, as shown in Figure (d). Figure 5C As shown, the second sliding protrusion 522b moves from the second position A2 along the inlet direction (X1 direction) to move out of the recess of the limiting channel 543, and continues to slide along the limiting channel 543 until it moves out of the limiting channel 543 (a part of the limiting channel 543 is inclined to allow the second sliding protrusion 522b to move out), thereby releasing the lock on the bearing body 2.

[0106] like Figure 5D As shown in Figure (e), after unlocking, the telescopic end of the elastic member 53 extends along the X2 direction under its own elastic force, thereby driving the locking member 523 to move along the X2 direction. During this process, the locking member 523 pushes the supporting body 2 to move along the X2 direction until it moves to the exit position B1, that is, the cycle repeats as follows. Figure 5D The location shown in Figure (a) is shown in the diagram.

[0107] It should be noted that the locking component 523 can be moved into or out of the internal space of the housing 521 through the opening 521a of the housing 521, and the locking component 523 is detachably connected to the supporting body 2, and is configured as follows: Figure 5D As shown, during the process of the carrier body 2 moving from the open position B1 to the closed position B3, the locking component 523 remains connected to the carrier body 2 so as to lock the carrier body 2 in the closed position B3; during the process of the carrier body 2 moving from the closed position B3 to the open position B1, the locking component 523 separates from the carrier body 2 so as to allow the carrier body 2 to move independently to the closed position B3.

[0108] There are various ways in which the locking component 523 can be detachably connected to the supporting body 2. For example, the locking component 523 may include one of a magnet and an iron block, and the other of the magnet and the iron block may be provided on the surface of the supporting body 2 opposite to the locking component 523. Thus, as... Figure 5DAs shown, during the process of the carrying body 2 moving from the open position B1 to the closed position B3, the locking component 523 and the carrying body 2 are attracted and fixed to each other by a magnet and an iron block, so as to lock the carrying body 2 in the closed position B3; during the process of the carrying body 2 moving from the closed position B3 to the open position B1, the carrying body 2 can overcome the attraction between the magnet and the iron block and separate from the locking component 523 under the action of its own inertia, so as to enable the carrying body 2 to move independently to the closed position B3.

[0109] For example, the locking component 523 can be detachably connected to the supporting body 2 in the following ways: Figure 6A and Figure 6B The structure shown specifically includes a first latch 21 on the surface of the supporting body 2 opposite to the locking member 523'. The locking member 523' includes a second latch 523a, which is in its original state of being separated from the first latch 21 when it is outside the internal space of the housing 521', as shown in the diagram. Figure 6A As shown; during the process of the second latch 523a moving into the internal space of the outer shell 521' through the opening of the outer shell 521', it undergoes elastic deformation under the compression of the outer shell 521', so as to be able to engage with the first latch 21, as shown. Figure 6B As shown. Thus, as Figure 5D As shown, during the process of the carrier body 2 moving from the open position B1 to the closed position B3, the locking component 523' is pushed to move along the X1 direction, simultaneously causing the second latch 523a to move into the internal space of the outer shell 521' through the opening, so that it can lock the carrier body 2 in the closed position B3 by engaging with the first latch 21; during the process of the carrier body 2 moving from the closed position B3 to the open position B1, the carrier body 2 pulls the locking component 523' to move along the X2 direction, simultaneously causing the second latch 523a to move out of the internal space of the outer shell 521' through the opening, so that the second latch 523a returns to its original state of being separated from the first latch 21, thereby realizing the separation of the locking component 523' from the carrier body 2, so that the carrier body 2 can move independently to the closed position B3 under its own inertia. It should be noted that... Figure 6A and Figure 6B The structure shown in the figure adopts the same as Figure 5A The limiting component 522 and Figure 5B The guide and limiting part 54 in the middle has the same sliding fit method.

[0110] In some embodiments of this disclosure, optionally, the surface of the bearing body 2 that is away from the interior of the compartment (i.e., the front surface in the X2 direction) is flush with the outer surface of the compartment when the bearing body 2 is in the closed position, that is, the surface of the bearing body 2 that is away from the interior of the compartment is used as the compartment door.

[0111] At least one embodiment of this disclosure also provides an analysis apparatus. Figure 7 This is a schematic block diagram of an analysis apparatus provided according to at least one embodiment of the present disclosure. For example... Figure 7 As shown, the analysis apparatus 100 according to at least one example of the present disclosure may include at least a loading unit 110, an inlet / outlet unit 120, and a signal detection unit 130.

[0112] The loading section 110 is used to carry the detection chip, and the structure of the loading section 110 is, for example, adopted as follows: Figure 1B The structure shown is illustrated. In practical applications, different types and sizes of detection chips can be equipped with different loading sections 110.

[0113] The loading / unloading section 120 adopts the loading / unloading structure provided in at least one embodiment of the present disclosure to transport the loading section 110 to realize the loading section 110 entering or leaving the warehouse.

[0114] The signal detection unit 130 includes an optical sensor 131, wherein the optical sensor 131 is configured to receive light from the detection chip and perform detection based on the light from the detection chip when the in-and-out compartment 120 is in the closed position.

[0115] In some embodiments of this disclosure, optionally, such as Figure 1B As shown, an optical detection alignment region 14 is provided on the bottom surface of the chip recess 12. This optical detection alignment region 14 is directly opposite the signal detection unit 130 and located at the image center, i.e., at the image acquisition focal point. It is used to observe whether the type and size of the detection chip are compatible with the current mounting unit 110, and to observe whether the placement orientation of the detection chip in the chip recess 12 is correct, during chip installation. The optical detection alignment region 14 can be, for example, a recessed portion formed on the bottom surface of the chip recess 12, or other identifiable markings. It should be noted that the detection chip is usually transparent, therefore the optical detection alignment region 14 can be observed through the detection chip.

[0116] Optical sensor 131 is, for example, an image sensor configured to acquire images of a detection chip (e.g., biochip images) for analysis. For example, optical sensor 131 may include a charge-coupled device (CCD) or complementary metal-oxide-semiconductor (CMOS). However, it should be understood that in other embodiments, optical sensor 131 may also be a photodiode, photoresistor, infrared sensor, ultraviolet sensor, etc., and the embodiments of this disclosure are not limited thereto.

[0117] It should be noted that for the aforementioned charge-coupled device (CCD), since it can capture images in a single shot without stitching, the number of moving mechanical parts can be reduced, thereby decreasing the overall size of the device and making it easier to carry. Furthermore, optionally, after noise reduction and contrast enhancement of the original CCD image, the Hough transform method can be used to identify circular regions in the fluorescence signal to be measured in the image, calculate the coordinates of the center of these circles, and then divide the fluorescence region according to these coordinates. Additionally, the grayscale value of each region can be calculated on the original image, and the concentration of the sample to be measured can be obtained by comparing the calculated grayscale values ​​of each region with the grayscale values ​​of a standard concentration image.

[0118] Figure 8 This is a schematic block diagram of a signal detection unit according to at least one embodiment of the present disclosure. Figure 8 As shown, in at least one embodiment of this disclosure, in addition to the optical sensor 131, the signal detection unit 130 may also include a light source 132, a light transmission unit 133, and a bracket 134.

[0119] The light source 132 can be configured to provide light to illuminate the detection chip during use. The light transmission unit 133 can be configured to transmit the light provided by the light source 132 to the detection chip and to transmit the light emitted by the detection chip to the optical sensor 131 during use.

[0120] For example, the light source 132 can be of various types that emit visible light, infrared light, etc., including lasers or fluorescent light sources. The wavelengths of lasers and fluorescent light sources can be selected according to actual needs, and the embodiments disclosed herein do not limit this.

[0121] Figure 10A This is a side view of a signal detection unit according to at least one embodiment of the present disclosure. Figure 10B This is a side view of the signal detection unit according to at least one embodiment of the present disclosure. Figure 9 As shown, in some embodiments of this disclosure, the light transmission unit 133 may include a 90° turning prism system 1333 and a reflecting light path system 1332. The 90° turning prism system 1333 may be configured to transmit light from the detection chip to the optical sensor 131. The reflecting light path system 1332 may be configured to transmit light from the light source 132 to illuminate the detection chip, and the reflecting light path system 1332 may also include a filter that filters the light transmitted on the optical path from the detection chip to the optical sensor 131, allowing only light of a set wavelength to pass through. Both the 90° turning prism system 1333 and the reflecting light path system 1332 may employ conventional designs in the art, which will not be described in detail here. Additionally, optionally, the light source 132 may emit light through an illumination module 1321, which is used to ensure uniform light distribution.

[0122] like Figure 10A and Figure 10B As shown, in some embodiments, the signal detection unit 130 may further include an objective lens 1331. The objective lens 1331 is configured to collect light from the detection chip. For example, the objective lens 1331 may include a lens.

[0123] like Figure 10A and Figure 10B As shown, the bracket 134 is used to fix and support at least some components of the information detection unit 130, such as the light source 132 and the light transmission unit 133. In some embodiments, the bracket 134 is also provided with a focal length adjustment structure, which is configured to adjust the distance between the light transmission unit 133 and the detection chip so that the detection chip is at the focal point of the light transmission unit 133. Furthermore, as... Figure 10B As shown, the focus adjustment structure has a focus adjustment knob 1341 and a knob extension 1342 connected to the focus adjustment knob 1341. The knob extension 1342 extends to a side close to the light transmission section 133 to facilitate manual adjustment. The bracket 134 can adopt a conventional design in the art, which will not be described in detail here.

[0124] In some embodiments of this disclosure, such as Figure 9 As shown, the analysis device 100 also includes a controller 140 configured to signal-connect with the optical sensor 131 to analyze light from the detection chip. The one or more controllers may be configured to perform at least one of the following operations:

[0125] Connected to the in / out section 120 signal to control the in / out of the in / out section 120; and

[0126] It is connected to the optical sensor 131 to analyze the light from the detection chip.

[0127] The aforementioned controller can be implemented, for example, by a central processing unit (CPU), a digital signal processor (DSP), a microcontroller, a field-programmable gate array (FPGA), a complex programmable logic device (CPLD), an application-specific integrated circuit (ASIC), etc., and the embodiments disclosed herein do not limit this.

[0128] It should be understood that in some embodiments of this disclosure, the controller may be implemented as multiple sub-controllers, each of which may perform at least one of the above operations. These multiple sub-controllers may be separately configured or integrated into a single controller, and the embodiments of this disclosure do not limit this.

[0129] In some embodiments of this disclosure, the analysis device 100 may further include a communication unit. This communication unit is configured to form a signal connection with a mobile terminal, server, or the like. This signal connection may be wired or wireless, and the embodiments of this disclosure are not limited in this regard. Exemplary wireless connections include Wi-Fi, Bluetooth, WirelessDirect, and infrared. Exemplary wired connections include Universal Serial Bus (USB), FireWire, Thunderbolt, or any connection requiring a physical cable.

[0130] Figure 11 This is an internal assembly diagram of the analytical apparatus provided in at least one embodiment of this disclosure. (See diagram below.) Figure 11 As shown, the loading unit 110, the inlet / outlet unit 120, and the signal detection unit 130 are all integrated on the base plate 3, and the power adapter 32 is also integrated on the base plate 3. Optionally, four feet 31 are provided at the bottom of the base plate 3. The lower ends of the four feet 31 are located outside the chamber of the analysis device, and the upper ends extend into the interior of the chamber and are fixedly connected to the bottom of the base plate 3. In addition, a development board 6 is installed on the inner surface of the chamber (not shown in the figure), which integrates the aforementioned control unit 140.

[0131] Figure 12A and Figure 12B These are two assembly drawings of the chamber 7 of the analysis apparatus according to at least one embodiment of this disclosure. Figure 12A As shown, the analysis apparatus according to at least one embodiment of this disclosure may further include a display screen 71. The display screen 71 may be disposed on the front of the housing 7 and configured for display, for example, as a liquid crystal display screen, an organic light-emitting diode (OLED) display screen, a quantum dot light-emitting diode (QLED) display screen, a micro-light-emitting diode display screen, an electronic ink screen, an electronic paper display screen, etc., and the embodiments of this disclosure are not limited thereto. For example, the display screen 71 may be a touch screen to receive user input. However, it should be understood that in some embodiments, the analysis apparatus may not include a display screen 71, but may be connected to a separately provided display screen or output data, such as analysis results, in the form of digital or physical files, and the embodiments of this disclosure are not limited thereto.

[0132] Optionally, the front of the compartment 7 may also be provided with a compartment opening, which allows the compartment section 120 to extend out from there so that the detection chip can be loaded on the loading section 110.

[0133] Optionally, a switch 72 may be provided on the front of the housing 7 to turn the development board 6 on or off.

[0134] Optionally, the analysis device may further include a data transmission interface. This data transmission interface is configured to output data from the analysis device, such as analysis results, to an external device, or to transmit data from an external device to the analysis device. The data transmission interface may be a Universal Serial Bus (USB) interface, a Serial Advanced Technology Attachment (SATA) interface, etc. In at least one embodiment, the data transmission interface and the power interface may be combined into a single interface, such as a USB interface, which can be used for both data transmission and power transmission. The analysis device according to at least one embodiment of this disclosure may also include buttons. The buttons are configured to receive user input commands and may be, for example, mechanical buttons, optical buttons, etc., and the embodiments of this disclosure do not limit this.

[0135] In practical applications, the analysis device 100 may include at least one of the following groups: a display screen, a touch sensor, a power interface, and a data transmission interface. The embodiments disclosed herein are not limiting in this regard.

[0136] At least one embodiment of this disclosure also provides an analysis system. Figure 13 This is a schematic block diagram of an analysis system according to at least one embodiment of the present disclosure. Figure 13 As shown, the analysis system 300 includes an analysis device 310 and a detection chip 320. For example, the analysis device 310 and the unused detection chip 320 can be combined and provided to a user for use. The analysis device 310 can be any of the analysis devices described above. The detection chip 320 can be any of the detection chips described above.

[0137] The following points need to be explained:

[0138] (1) The accompanying drawings of the embodiments of this disclosure only involve the structures involved in the embodiments of this disclosure. Other structures can be referred to the general design.

[0139] (2) Where there is no conflict, the embodiments of this disclosure and the features in the embodiments can be combined with each other to obtain new embodiments.

[0140] The above description is merely a specific embodiment of this disclosure, but the scope of protection of this disclosure is not limited thereto. The scope of protection of this disclosure should be determined by the scope of protection of the claims.

Claims

1. An in-and-out compartment structure for an analytical device, used to transport a loading section of the analytical device for carrying a detection chip, so as to realize the entry or exit of the loading section, wherein, The loading / unloading structure includes a load-bearing body, a guide support assembly, and a door opening / closing assembly, wherein the load-bearing body is used to support the loading unit; The guide support assembly is disposed on the bottom plate inside the chamber of the analysis device to support the carrier body, and the guide support assembly is movably connected to the carrier body so that the carrier body can move in the direction of entering or exiting the chamber. The door opening and closing assembly is mounted on the base plate and located on the side of the supporting body away from the door. It is used to apply a pushing force towards the opening direction to the supporting body when the supporting body is subjected to a pressing force, so as to move the supporting body to the opening position, and lock the supporting body in the closing position when it is subjected to a pressing force again. The door opening and closing assembly includes a fixed bracket, a limiting structure disposed on the fixed bracket, and an elastic component connected to the limiting structure. The fixed bracket is fixed to the base plate and is located on the side of the supporting body away from the door. The limiting structure is connected to the elastic component and detachably connected to the carrying body. The limiting structure is configured such that: when the carrying body, in the closed position, is moved to the trigger position along the inlet direction by the pressing force, the limiting structure releases the locking of the carrying body and, under the elastic force of the elastic component, applies a thrust towards the outlet direction to the carrying body, causing the carrying body to move to the open position; when the carrying body, in the open position, is moved to the trigger position along the inlet direction by the pressing force, the limiting structure locks the carrying body in the closed position. The limiting structure includes a shell, a limiting component, and a locking component. The shell has an opening on the side opposite to the supporting body, and a guide limiting portion is provided on the inner surface of the shell. The elastic component is located in the internal space of the shell, and the fixed end of the elastic component is fixedly connected to the shell, while the telescopic end of the elastic component is fixedly connected to the locking component. The limiting component is rotatably connected to the telescopic end of the elastic component, and the limiting component is configured such that when the telescopic end of the elastic component extends or retracts in a direction approaching or away from the opening, it can drive the limiting component to slide along the guide limiting portion, so that the limiting component can sequentially pass through a first position, a second position, and a third position from an initial position. Specifically, when the limiting component is in the initial position, the supporting body is in the open position; when the limiting component is in the first position or the third position, the supporting body is in the trigger position; and when the limiting component is in the second position, the limiting component and the guide limiting portion are relatively fixed, and the supporting body is in the closed position. The locking component can be moved into or out of the interior space of the housing through the opening, and the locking component is detachably connected to the carrier body. It is configured such that: during the process of the carrier body moving from the open position to the closed position, the locking component remains connected to the carrier body to lock the carrier body in the closed position; during the process of the carrier body moving from the closed position to the open position, the locking component separates from the carrier body to allow the carrier body to move independently to the open position.

2. The inbound / outbound structure according to claim 1, wherein, The guide support assembly includes a support component, a guide rail, and a slider, wherein the support component is disposed on the base plate to support the load-bearing body; One of the guide rail and the slider is disposed on the surface of the support member opposite to the base plate, and the other of the guide rail and the slider is disposed on the surface of the bearing body facing the base plate; and the guide rail and the slider are slidably connected in the direction of entering or exiting the compartment.

3. The inbound / outbound structure according to claim 2, wherein, The support component includes a first support sub-component, a second support sub-component, and at least one roller, wherein the first support sub-component is fixedly connected to the base plate, and one of the guide rail and the slider is disposed on the surface of the first support sub-component opposite to the base plate; The second support sub-component is fixedly connected to the surface of the supporting body facing the bottom plate, and is close to the end of the supporting body away from the compartment door; The roller is mounted on the second support sub-component and makes rolling contact with the base plate.

4. The inbound / outbound structure according to claim 1, wherein, The locking component includes one of a magnet and an iron block, and the other of the magnet and the iron block is disposed on the surface of the supporting body opposite to the locking component.

5. The inbound / outbound structure according to claim 1, wherein, A first latch is provided on the surface of the supporting body opposite to the locking component. The locking component includes a second latch. When the second latch is outside the internal space of the housing, it is in its original state of being separated from the first latch. When the second latch moves into the internal space of the housing through the opening, it undergoes elastic deformation under the compression of the housing to engage with the first latch.

6. The inbound / outbound structure according to claim 1, wherein, The upper surface of the supporting body is provided with a receiving groove for accommodating the loading part; and a plurality of mounting holes are provided on the bottom surface of the receiving groove for detachable connection with the loading part by means of fasteners.

7. The inbound / outbound structure according to claim 1, wherein, When the bearing body is in the closed position, the surface of the bearing body that is away from the interior of the compartment is flush with the outer surface of the compartment.

8. An analytical apparatus, comprising: The loading section, the loading / unloading section, and the signal detection section, among which, The loading section is used to carry the detection chip; The loading / unloading section adopts the loading / unloading structure described in any one of claims 1-7, and is used to transport the loading section to realize the loading section entering or leaving the warehouse; The signal detection unit includes an optical sensor, wherein the optical sensor is configured to receive light from the detection chip and perform detection based on the light when the in-and-out compartment is in the closed position.

9. The analytical apparatus according to claim 8, wherein, The loading unit includes a loading plate, and a chip groove is provided on the first plate surface of the loading plate for accommodating the detection chip; and the shape and size of the chip groove are adapted to the shape and size of the detection chip. A pick-and-place groove is also provided on the first plate surface, and the pick-and-place groove is connected to the chip groove.

10. The analytical apparatus according to claim 9, wherein, There are two pick-and-place grooves, which are symmetrically arranged on two opposite sides of the chip groove.

11. The analytical apparatus according to claim 9, wherein, An optical detection centering area is provided on the bottom surface of the chip recess. The optical detection centering area is directly opposite the signal detection unit and is located at the center of the image.

12. The analytical apparatus according to claim 8, wherein, The optical sensor is an image sensor, configured to acquire optical images of the detection chip for analysis.

13. The analytical apparatus according to claim 12, wherein, The image sensor is a charge-coupled device.

14. The analytical apparatus according to claim 8, wherein, The signal detection unit also includes: A light source configured to provide light to illuminate the detection chip during use; The light transmission unit is configured to transmit light provided by the light source to the detection chip and light emitted by the detection chip to the optical sensor during use; and A bracket is provided for fixing and supporting the light source and the light transmission unit. A focal length adjustment structure is also provided on the bracket. The focal length adjustment structure is configured to adjust the distance between the light transmission unit and the detection chip so that the detection chip is located at the focal point of the light transmission unit. Furthermore, the focal length adjustment structure has a focal length adjustment knob and a knob extension connected to the focal length adjustment knob. The knob extension extends to the side close to the light transmission unit to facilitate manual adjustment.

15. The analytical apparatus according to claim 8, wherein, The analysis device further includes a controller configured to be connected to the optical sensor signal to analyze the light from the detection chip.

16. The analytical apparatus according to claim 8, wherein, The analysis device further includes at least one of the following: a display screen, a touch sensor, a power interface, and a data transmission interface.

17. The analytical apparatus according to claim 8, wherein, The analytical device is applied to microfluidic chips.

18. An analysis system, comprising: The analytical apparatus as described in any one of claims 8 to 17; as well as The detection chip.

Images