Fused tricyclic KRAS inhibitors

Abstract

Disclosed are compounds of formula (I), methods for inhibiting KRAS activity using the compounds, and pharmaceutical compositions comprising the compounds. The compounds can be used to treat, prevent, or improve diseases or conditions associated with KRAS activity, such as cancer.

Description

[0001] Related applications

[0002] This application is related to U.S. Provisional Application No. 63 / 011,089, filed on April 16, 2020, and U.S. Provisional Application No. 63 / 146,899, filed on February 8, 2021, the entire contents of which are hereby incorporated by reference in their entirety. Technical Field

[0003] The present disclosure provides compounds, compositions, and methods of use thereof that modulate KRAS activity and are useful in treating various diseases, including cancer. Background Art

[0004] Ras proteins are part of a family of small GTPases that are activated by growth factors and various extracellular stimuli. The Ras family regulates intracellular signaling pathways responsible for cell growth, migration, survival, and differentiation. Activation of RAS proteins at the cell membrane causes the binding of key effectors and the activation of a cascade of intracellular signaling pathways, including RAF and PI3K kinase pathways. Somatic mutations in RAS cause uncontrolled cell growth and malignant transformation, while activation of RAS proteins is closely regulated in normal cells (Simanshu, D. et al. Cell 170.1 (2017): 17-33).

[0005] The Ras family includes three members: KRAS, NRAS, and HRAS. RAS-mutated cancers account for approximately 25% of human cancers. KRAS is the most commonly mutated isoform, accounting for 85% of all RAS mutations, while NRAS and HRAS account for 12% and 3% of all Ras-mutated cancers, respectively (Simanshu, D. et al. Cell 170.1 (2017): 17-33). KRAS mutations are prevalent in the top three most lethal cancer types: pancreatic cancer (97%), colorectal cancer (44%), and lung cancer (30%) (Cox, AD et al. Nat Rev Drug Discov (2014) 13: 828-51). Most RAS mutations occur at amino acid residues 12, 13, and 61. The frequency of specific mutations varies between RAS gene isoforms, with G12 and Q61 mutations predominating in KRAS and NRAS, respectively, while G12, G13, and Q61 mutations are most common in HRAS. In addition, the mutation spectrum of RAS isoforms varies with cancer type. For example, KRAS G12D is predominant in pancreatic cancer (51%), followed by colorectal adenocarcinoma (45%) and lung cancer (17%), while KRAS G12 V mutations are associated with pancreatic cancer (30%), followed by colorectal adenocarcinoma (27%) and lung adenocarcinoma (23%) (Cox, AD et al. Nat Rev Drug Discov (2014) 13: 828-51). In contrast, KRAS G12C mutations are predominant in non-small cell lung cancer (NSCLC), including 11-16% of lung adenocarcinomas, and 2-5% of pancreatic cancer and colorectal adenocarcinomas (Cox, AD et al. Nat. Rev. Drug Discov. (2014) 13: 828-51). Genomic studies of hundreds of cancer cell lines have shown that cancer cells with KRAS mutations are largely dependent on KRAS function for cell growth and survival (McDonald, R. et al. Cell 170 (2017): 577-592). The role of mutant KRAS as an oncogenic driver has been further supported by in-depth in vivo experimental evidence showing that mutant KRAS is required for early tumor development and maintenance in animal models (Cox, AD et al. Nat Rev Drug Discov (2014) 13: 828-51).

[0006] Collectively, these findings suggest that KRAS mutations play a critical role in human cancer; therefore, the development of inhibitors targeting mutant KRAS could be used clinically to treat diseases characterized by KRAS mutations. Summary of the Invention

[0007] The present disclosure provides, inter alia, a compound of formula I:

[0008]

[0009]

[0010] or a pharmaceutically acceptable salt thereof, wherein the composition variables are as defined herein.

[0011] The present disclosure also provides a pharmaceutical composition comprising a compound of the present disclosure or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient.

[0012] The present disclosure also provides a method of inhibiting KRAS activity, comprising administering a compound of the present disclosure, or a pharmaceutically acceptable salt thereof, to an individual. The present disclosure also provides the use of the compound described herein in the manufacture of a medicament for use in therapy. The present disclosure also provides a compound described herein for use in therapy.

[0013] The present disclosure also provides methods of treating a disease or condition in a patient, the methods comprising administering to the patient a therapeutically effective amount of a compound of the present disclosure or a pharmaceutically acceptable salt thereof. DETAILED DESCRIPTION

[0014] Compound

[0015] In one aspect, provided herein is a compound of Formula I:

[0016]

[0017] or a pharmaceutically acceptable salt thereof,

[0018] in:

[0019] each independently represents a single bond or a double bond;

[0020] X is N or CR 7 ;

[0021] Y is N or C;

[0022] R 1 Selected from H, D, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, CN, OR a1 SR a1 、C(O)R b1 、C(O)NR c1 Rd1 、C(O)OR a1 、OC(O)R b1 、OC(O)NR c1 R d1 NR c1 R d1 NR c1 C(O)R b1 NR c1 C(O)OR a1 NR c1 C(O)NR c1 R d1 NR c1 S(O)R b1 NR c1 S(O)2R b1 NR c1 S(O)2NR c1 R d1 、S(O)R b1 、S(O)NR c1 R d1 、S(O)2R b1 、S(O)2NR c1 R d1 and BR h1 R i1 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0023] R 2 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a2 SR a2 、C(O)R b2、C(O)NR c2 R d2 、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 NR c2 R d2 NR c2 C(O)R b2 NR c2 C(O)OR a2 NR c2 C(O)NR c2 R d2 、C(=NR e2 )R b2 、C(=NOR a2 )R b2 、C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )R b2 NR c2 S(O)R b2 NR c2 S(O)2R b2 NR c2 S(O)2NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O)2R b2 、S(O)2NR c2 R d2 and BR h2 R i2 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R22 Substituents substituted;

[0024] Cy 1 Selected from C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 wherein the 4-10 membered heterocycloalkyl and the 5-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl; and wherein the C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 10 Substituents substituted;

[0025] R 3 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR f3 SR a3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 NR c3 R j3 NR c3 C(O)R b3 NR c3 C(O)OR a3 NR c3 C(O)NR c3 R d3 、C(=NR e3 )R b3 、C(=NOR a3 )Rb3 、C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )R b3 NR c3 S(O)R b3 NR c3 S(O)2R b3 NR c3 S(O)2NR c3 R d3 、S(O)R b3 、S(O)NR c3 R d3 、S(O)2R b3 、S(O)2NR c3 R d3 and BR h3 R i3 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0026] When R 4 R 5 C YR 6 is a single bond and Y is C, then YR 6 is selected from C═O and C═S; and

[0027] R 4 Selected from H, D, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, CN, OR a4SR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 NR c4 R d4 NR c4 C(O)R b4 NR c4 C(O)OR a4 NR c4 C(O)NR c4 R d4 NR c4 S(O)R b4 NR c4 S(O)2R b4 NR c4 S(O)2NR c4 R d4 、S(O)R b4 、S(O)NR c4 R d4 、S(O)2R b4 、S(O)2NR c4 R d4 and BR h4 R i4 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0028] R 5 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a5SR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 C(O)R b5 NR c5 C(O)OR a5 NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NOR a5 )R b5 、C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )R b5 NR c5 S(O)R b5 NR c5 S(O)2R b5 NR c5 S(O)2NR c5 R d5 、S(O)R b5 、S(O)NR c5 R d5 、S(O)2R b5 、S(O)2NR c5 R d5 and BR h5 R i5 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted;

[0029] When R 4 R 5 C YR 6 is a double bond and Y is N, then R 4 and R 6 does not exist;

[0030] When R 4 R 5 C YR 6 is a double bond and Y is C, then R 4 does not exist; and

[0031] R 6 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a6 SR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 NR c6 R d6 NR c6 C(O)R b6 NR c6 C(O)OR a6 NR c6 C(O)NR c6 R d6 、C(=NR e6 )R b6 、C(=NOR a6 )R b6 、C(=NR e6 )NRc6 R d6 NR c6 C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )R b6 NR c6 S(O)R b6 NR c6 S(O)2R b6 NR c6 S(O)2NR c6 R d6 、S(O)R b6 、S(O)NR c6 R d6 、S(O)2R b6 、S(O)2NR c6 R d6 and BR h6 R i6 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 60 Substituents substituted;

[0032] R 7 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a7 SRa7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NOR a7 )R b7 、C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )R b7 NR c7 S(O)R b7 NR c7 S(O)2R b7 NR c7 S(O)2NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O)2R b7 、S(O)2NR c7 R d7 and BR h7 R i7 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 70 Substituents substituted;

[0033] Cy 2 Selected from C 3-10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6-10 wherein the 4-14 membered heterocycloalkyl and the 5-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-14 membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl; and wherein the C 3-10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 20 Substituents substituted;

[0034] Each R 10 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a10 SR a10 、C(O)R b10 、C(O)NR c10 R d10 、C(O)OR a10 、OC(O)R b10 、OC(O)NR c10 R d10 NR c10 R d10 NR c10 C(O)R b10 NR c10 C(O)OR a10 NR c10 C(O)NR c10 R d10 、C(=NR e10)R b10 、C(=NOR a10 )R b10 、C(=NR e10 )NR c10 R d10 NR c10 C(=NR e10 )NR c10 R d10 NR c10 S(O)R b10 NR c10 S(O)2R b10 NR c10 S(O)2NR c10 R d10 、S(O)R b10 、S(O)NR c10 R d10 、S(O)2R b10 、S(O)2NR c10 R d10 and BR h10 R i10 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 11 Substituents substituted;

[0035] Each R 11 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, ORa11 SR a11 、C(O)R b11 、C(O)NR c11 R d11 、C(O)OR a11 、OC(O)R b11 、OC(O)NR c11 R d11 NR c11 R d11 NR c11 C(O)R b11 NR c11 C(O)OR a11 NR c11 C(O)NR c11 R d11 NR c11 S(O)R b11 NR c11 S(O)2R b11 NR c11 S(O)2NR c11 R d11 、S(O)R b11 、S(O)NR c11 R d11 、S(O)2R b11 、S(O)2NR c11 R d11 and BR h11 R i11 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 12 Substituents substituted;

[0036] Each R 12 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, ORa12 SR a12 、C(O)R b12 、C(O)NR c12 R d12 、C(O)OR a12 、OC(O)R b12 、OC(O)NR c12 R d12 NR c12 R d12 NR c12 C(O)R b12 NR c12 C(O)OR a12 NR c12 C(O)NR c12 R d12 NR c12 S(O)R b12 NR c12 S(O)2R b12 NR c12 S(O)2NR c12 R d12 、S(O)R b12 、S(O)NR c12 R d12 、S(O)2R b12 、S(O)2NR c12 R d12 and BR h12 R i12 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0037] Each R 20 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3Alkylene, halo, D, CN, NO2, OR a20 SR a20 、C(O)R b20 、C(O)NR c20 R d20 、C(O)OR a20 、OC(O)R b20 、OC(O)NR c20 R d20 NR c20 R d20 NR c20 C(O)R b20 NR c20 C(O)OR a20 NR c20 C(O)NR c20 R d20 、C(=NR e20 )R b20 、C(=NOR a20 )R b20 、C(=NR e20 )NR c20 R d20 NR c20 C(=NR e20 )NR c20 R d20 NR c20 S(O)R b20 NR c20 S(O)2R b20 NR c20 S(O)2NR c20 R d20 、S(O)R b20 、S(O)NR c20 R d20 、S(O)2R b20 、S(O)2NR c20 R d20 and BR h20 R i20 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 21 Substituents substituted;

[0038] Each R 21 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a21 SR a21 、C(O)R b21 、C(O)NR c21 R d21 、C(O)OR a21 、OC(O)R b21 、OC(O)NR c21 R d21 NR c21 R d21 NR c21 C(O)R b21 NR c21 C(O)OR a21 NR c21 C(O)NR c21 R d21 NR c21 S(O)R b21 NR c21 S(O)2R b21 NR c21 S(O)2NR c21 R d21 、S(O)R b21 、S(O)NR c21 R d21 、S(O)2R b21 、S(O)2NR c21 R d21 and BR h21 R i21 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0039] Each R 22 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a22 SR a22 、C(O)R b22 、C(O)NR c22 R d22 、C(O)OR a22 、OC(O)R b22 、OC(O)NR c22 R d22 NR c22 R d22 NR c22 C(O)R b22 NR c22 C(O)OR a22 NR c22 C(O)NR c22 R d22 NR c22 S(O)R b22 NR c22 S(O)2R b22 NR c22 S(O)2NR c22 R d22 、S(O)R b22 、S(O)NR c22 R d22 、S(O)2R b22、S(O)2NR c22 R d22 and BR h22 R i22 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 23 Substituents substituted;

[0040] Each R 23 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a23 SR a23 、C(O)R b23 、C(O)NR c23 R d23 、C(O)OR a23 、OC(O)R b23 、OC(O)NR c23 R d23 NR c23 R d23 NR c23 C(O)R b23 NR c23 C(O)OR a23 NR c23 C(O)NR c23 R d23 NR c23 S(O)R b23 NR c23S(O)2R b23 NR c23 S(O)2NR c23 R d23 、S(O)R b23 、S(O)NR c23 R d23 、S(O)2R b23 、S(O)2NR c23 R d23 and BR h23 R i23 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 24 Substituents substituted;

[0041] Each R 24 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a24 SR a24 、C(O)R b24 、C(O)NR c24 R d24 、C(O)OR a24 、OC(O)R b24 、OC(O)NR c24 R d24 NR c24 R d24 NR c24 C(O)R b24 NR c24 C(O)OR a24 NR c24 C(O)NR c24 R d24 NR c24 S(O)R b24 NR c24S(O)2R b24 NR c24 S(O)2NR c24 R d24 、S(O)R b24 、S(O)NR c24 R d24 、S(O)2R b24 、S(O)2NR c24 R d24 and BR h24 R i24 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0042] Each R 30 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a30 SR a30 、C(O)R b30 、C(O)NR c30 R d30 、C(O)OR a30 、OC(O)R b30 、OC(O)NR c30 R d30 NR c30 R d30 NR c30 C(O)R b30 NR c30 C(O)OR a30 NR c30 C(O)NR c30 R d30 NR c30 S(O)R b30 NRc30 S(O)2R b30 NR c30 S(O)2NR c30 R d30 、S(O)R b30 、S(O)NR c30 R d30 、S(O)2R b30 、S(O)2NR c30 R d30 and BR h30 R i30 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 Substituents substituted;

[0043] Each R 31 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a31 SR a31 、C(O)R b31 、C(O)NR c31 R d31 、C(O)OR a31 、OC(O)R b31 、OC(O)NR c31 R d31 NR c31 R d31 NR c31C(O)R b31 NR c31 C(O)OR a31 NR c31 C(O)NR c31 R d31 NR c31 S(O)R b31 NR c31 S(O)2R b31 NR c31 S(O)2NR c31 R d31 、S(O)R b31 、S(O)NR c31 R d31 、S(O)2R b31 、S(O)2NR c31 R d31 and BR h31 R i31 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 32 Substituents substituted;

[0044] Each R 32 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a32 SR a32 、C(O)R b32 、C(O)NR c32 R d32 、C(O)OR a32 、OC(O)R b32 、OC(O)NR c32 R d32 NR c32 R d32 NR c32C(O)R b32 NR c32 C(O)OR a32 NR c32 C(O)NR c32 R d32 NR c32 S(O)R b32 NR c32 S(O)2R b32 NR c32 S(O)2NR c32 R d32 、S(O)R b32 、S(O)NR c32 R d32 、S(O)2R b32 、S(O)2NR c32 R d32 and BR h32 R i32 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0045] Each R 50 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a50 SR a50 、C(O)R b50 、C(O)NR c50 R d50 、C(O)OR a50 、OC(O)R b50 、OC(O)NR c50 R d50 NR c50 R d50 NR c50C(O)R b50 NR c50 C(O)OR a50 NR c50 C(O)NR c50 R d50 NR c50 S(O)R b50 NR c50 S(O)2R b50 NR c50 S(O)2NR c50 R d50 、S(O)R b50 、S(O)NR c50 R d50 、S(O)2R b50 、S(O)2NR c50 R d50 and BR h50 R i50 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 51 Substituents substituted;

[0046] Each R 51 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, C 6-10 Aryl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a51 SR a51 、C(O)R b51 、C(O)NR c51 R d51 、C(O)OR a51 、OC(O)R b51 、OC(O)NR c51 R d51 NR c51 R d51NR c51 C(O)R b51 NR c51 C(O)OR a51 NR c51 C(O)NR c51 R d51 NR c51 S(O)R b51 NR c51 S(O)2R b51 NR c51 S(O)2NR c51 R d51 、S(O)R b51 、S(O)NR c51 R d51 、S(O)2R b51 、S(O)2NR c51 R d51 and BR h51 R i51 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 6-10 Aryl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 52 Substituents substituted;

[0047] Each R 52 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a52 SR a52 、C(O)R b52 、C(O)NR c52 R d52 、C(O)OR a52 、OC(O)R b52 、OC(O)NR c52 R d52 NR c52 R d52 NR c52 C(O)R b52 NR c52 C(O)OR a52 NR c52 C(O)NR c52 R d52 NRc52 S(O)R b52 NR c52 S(O)2R b52 NR c52 S(O)2NR c52 R d52 、S(O)R b52 、S(O)NR c52 R d52 、S(O)2R b52 、S(O)2NR c52 R d52 and BR h52 R i52 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0048] Each R 60 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a60 SR a60 、C(O)R b60 、C(O)NR c60 R d60 、C(O)OR a60 、OC(O)R b60 、OC(O)NR c60 R d60 NR c60 R d60 NR c60 C(O)R b60 NR c60 C(O)OR a60 NR c60 C(O)NR c60 R d60NR c60 S(O)R b60 NR c60 S(O)2R b60 NR c60 S(O)2NR c60 R d60 、S(O)R b60 、S(O)NR c60 R d60 、S(O)2R b60 、S(O)2NR c60 R d60 and BR h60 R i60 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0049] Each R 70 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a70 SR a70 、C(O)R b70 、C(O)NR c70 R d70 、C(O)OR a70 、OC(O)R b70 、OC(O)NR c70 R d70NR c70 R d70 NR c70 C(O)R b70 NR c70 C(O)OR a70 NR c70 C(O)NR c70 R d70 NR c70 S(O)R b70 NR c70 S(O)2R b70 NR c70 S(O)2NR c70 R d70 、S(O)R b70 、S(O)NR c70 R d70 、S(O)2R b70 、S(O)2NR c70 R d70 and BR h70 R i70 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 71 Substituents substituted;

[0050] Each R 71 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a71SR a71 、C(O)R b71 、C(O)NR c71 R d71 、C(O)OR a71 、OC(O)R b71 、OC(O)NR c71 R d71 NR c71 R d71 NR c71 C(O)R b71 NR c71 C(O)OR a71 NR c71 C(O)NR c71 R d71 NR c71 S(O)R b71 NR c71 S(O)2R b71 NR c71 S(O)2NR c71 R d71 、S(O)R b71 、S(O)NR c71 R d71 、S(O)2R b71 、S(O)2NR c71 R d71 and BR h71 R i71 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 72 Substituents substituted;

[0051] Each R 72 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a72SR a72 、C(O)R b72 、C(O)NR c72 R d72 、C(O)OR a72 、OC(O)R b72 、OC(O)NR c72 R d72 NR c72 R d72 NR c72 C(O)R b72 NR c72 C(O)OR a72 NR c72 C(O)NR c72 R d72 NR c72 S(O)R b72 NR c72 S(O)2R b72 NR c72 S(O)2NR c72 R d72 、S(O)R b72 、S(O)NR c72 R d72 、S(O)2R b72 、S(O)2NR c72 R d72 and BR h72 R i72 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0052] Each R a1 、R b1 、R c1 and R d1 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0053] or any R attached to the same N atom c1 and R d1 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R g a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0054] Each R h1 and R i1 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h1 and R i1 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0055] Each R a2 、R b2 、R c2 and R d2 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 22 Substituents substituted;

[0056] or any R attached to the same N atom c2 and R d2 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 22 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0057] Each R e2 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0058] Each R h2 and R i2 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h2 and R i2 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0059] Each R a3 、R b3 、R c3 and R d3 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0060] or any R attached to the same N atom c3 and R d3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 30 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0061] Each R e3 Independently selected from H, CN, C1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0062] Each R f3 and R j3 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0063] or any R attached to the same N atom c3 and R j3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 30 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0064] Each R h3 and R i3 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h3 and R i3 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0065] Each R a4 、R b4 、Rc4 and R d4 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0066] or any R attached to the same N atom c4 and R d4 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R g a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0067] Each R h4 and R i4 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h4 and R i4 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0068] Each R a5 、R b5 、R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted;

[0069] or any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 50 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0070] Each R e5 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0071] Each R h5 and R i5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h5 and R i5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0072] Each R a6 、R b6 、R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 60 Substituents substituted;

[0073] or any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 60 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0074] Each R e6 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0075] Each R h6 and R i6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h6 and R i6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0076] Each R a7 、R b7 、R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 70 Substituents substituted;

[0077] or any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 70 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0078] Each R e7 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0079] Each R h7 and R i7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h7 and R i7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0080] Each R a10 、R b10 、R c10 and R d10 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 11 Substituents substituted;

[0081] or any R attached to the same N atom c10 and R d10 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 11 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0082] Each R e10 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0083] Each R h10 and R i10 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h10 and R i10 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0084] Each R a11 、R b11 、R c11 and R d11 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 12 Substituents substituted;

[0085] or any R attached to the same N atom c11 and R d11 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 12 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0086] Each R h11 and R i11 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h11 and R i11 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0087] Each R a12 、R b12 、R c12 and R d12 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0088] Each R h12 and R i12 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h12 and R i12 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0089] Each R a20 、R b20 、R c20 and R d20 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 21 Substituents substituted;

[0090] or any R attached to the same N atom c20 and R d20 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 21 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0091] Each R e20 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0092] Each R h20 and R i20 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h20 and R i20 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0093] Each R a21 、R b21 、R c21 and R d21 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0094] or any R attached to the same N atom c21 and R d21 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R g a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0095] Each R h21 and R i21 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h21 and R i21 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0096] Each R a22 、R b22 、R c22 and R d22 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 23 Substituents substituted;

[0097] or any R attached to the same N atom c22 and R d22 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 23 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0098] Each R h22 and R i22 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h22 and R i22 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0099] Each R a23 、R b23 、R c23 and R d23 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 24 Substituents substituted;

[0100] or any R attached to the same N atom c23 and R d23 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 24 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0101] Each R h23 and R i23 Independently selected from OH, C 1-6 Alkoxy and C1-6 or any R attached to the same B atom h23 and R i23 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0102] Each R a24 、R b24 、R c24 and R d24 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0103] Each R h24 and R i24 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h24 and R i24 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0104] Each R a30 、R b30 、R c30 and R d30 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 Substituents substituted;

[0105] or any R attached to the same N atom c30 and R d30 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 31 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0106] Each R h30 and R i30 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h30 and R i30 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0107] Each R a31 、R b31 、R c31 and R d31 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 32 Substituents substituted;

[0108] or any R attached to the same N atom c31 and R d31 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 32 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0109] Each R h31 and R i31 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h31 and R i31 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0110] Each R a32 、R b32 、R c32 and R d32 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0111] Each R h32 and R i32 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h32 and R i32 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0112] Each R a50 、R b50 、R c50 and R d50 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 51 Substituents substituted;

[0113] or any R attached to the same N atom c50 and R d50 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 51a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0114] Each R h50 and R i50 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h50 and R i50 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0115] Each R a51 、R b51 、R c51 and R d51 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 52 Substituents substituted;

[0116] or any R attached to the same N atom c51 and R d51 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 52 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0117] Each R h51 and R i51 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h51 and R i51 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0118] Each R a52 、R b52 、Rc52 and R d52 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0119] Each R h52 and R i52 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h52 and R i52 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0120] Each R a60 、R b60 、R c60 and R d60 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0121] or any R attached to the same N atom c60 and R d60 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R g a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0122] Each R h60 and R i60 Independently selected from OH, C 1-6Alkoxy and C 1-6 or any R attached to the same B atom h60 and R i60 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0123] Each R a70 、R b70 、R c70 and R d70 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 71 Substituents substituted;

[0124] or any R attached to the same N atom c70 and R d70 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 71 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0125] Each R h70 and R i70 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h70 and R i70 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0126] Each R a71 、R b71 、R c71 and R d71 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 72 Substituents substituted;

[0127] or any R attached to the same N atom c71 and R d71 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 72 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0128] Each R h71 and R i71 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h71 and R i71 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0129] Each R a72 、R b72 、R c72 and R d72 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0130] Each R h72 and R i72 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h72 and R i72 Together with the B atom to which it is attached, it forms a1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group; and

[0131] Each R g Independently selected from D, OH, NO2, CN, halo, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-2 Alkylene, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 1-3 Alkoxy-C 1-3 Alkyl, C 1-3 Alkoxy-C 1-3 Alkoxy, HO-C 1-3 Alkoxy, HO-C 1-3 Alkyl, cyano-C 1-3 Alkyl, H2N-C 1-3 Alkyl, amino, C 1-6 Alkylamino, di(C 1-6 alkyl)amino, thio, C 1-6 Alkylthio, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, carboxyl, C 1-6 Alkylcarbonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylcarbonylamino, C 1-6 Alkoxycarbonylamino, C 1-6 Alkylcarbonyloxy, aminocarbonyloxy, C 1-6 Alkylaminocarbonyloxy, di(C 1-6 alkyl)aminocarbonyloxy, C 1-6 Alkylsulfonylamino, aminosulfonyl, C 1-6 Alkylaminosulfonyl, di(C 1-6 alkyl)aminosulfonyl, aminosulfonylamino, C 1-6 Alkylaminosulfonylamino, di(C 1-6 alkyl)aminosulfonylamino, aminocarbonylamino, C 1-6 Alkylaminocarbonylamino and di(C 1-6 alkyl)aminocarbonylamino;

[0132] The condition is that when R 4 R 5 C YR 6 is a double bond and Y is N, Cy 1 Not 3,5-dimethylisoxazol-4-yl.

[0133] In another aspect, provided herein is a compound of Formula I:

[0134]

[0135] or a pharmaceutically acceptable salt thereof,

[0136] in:

[0137] each independently represents a single bond or a double bond;

[0138] X is N or CR 7 ;

[0139] Y is N or C;

[0140] R 1 Selected from H, D, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, CN, OR a1 SR a1 、C(O)R b1 、C(O)NR c1 R d1 、C(O)OR a1 、OC(O)R b1 、OC(O)NR c1 R d1 NR c1 R d1 NR c1 C(O)R b1 NR c1 C(O)OR a1 NR c1 C(O)NR c1 R d1 NR c1 S(O)R b1 NR c1 S(O)2R b1 NR c1 S(O)2NR c1 R d1 、S(O)R b1 、S(O)NR c1 R d1、S(O)2R b1 、S(O)2NR c1 R d1 and BR h1 R i1 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0141] R 2 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a2 SR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 NR c2 R d2 NR c2 C(O)R b2 NR c2 C(O)OR a2 NR c2 C(O)NR c2 R d2 、C(=NR e2 )R b2 、C(=NOR a2 )R b2 、C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2)NR c2 R d2 NR c2 C(=NR e2 )R b2 NR c2 S(O)R b2 NR c2 S(O)2R b2 NR c2 S(O)2NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O)2R b2 、S(O)2NR c2 R d2 and BR h2 R i2 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 22 Substituents substituted;

[0142] Cy 1 Selected from C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 wherein the 4-10 membered heterocycloalkyl and the 5-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl; and wherein the C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 10 Substituents substituted;

[0143] R 3 Selected from H, C 1-6 Alkyl, C 2-6Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR f3 SR a3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 NR c3 R j3 NR c3 C(O)R b3 NR c3 C(O)OR a3 NR c3 C(O)NR c3 R d3 、C(=NR e3 )R b3 、C(=NOR a3 )R b3 、C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )R b3 NR c3 S(O)R b3 NR c3 S(O)2R b3 NR c3 S(O)2NR c3 R d3 、S(O)R b3 、S(O)NR c3 R d3 、S(O)2R b3 、S(O)2NR c3 R d3 and BRh3 R i3 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0144] When R 4 R 5 C YR 6 is a single bond and Y is C, then YR 6 is selected from C═O and C═S; and

[0145] R 4 Selected from H, D, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, CN, OR a4 SR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 NR c4 R d4 NR c4 C(O)R b4 NR c4 C(O)OR a4 NR c4 C(O)NR c4 R d4 NR c4 S(O)R b4 NR c4 S(O)2R b4 NR c4 S(O)2NR c4 Rd4 、S(O)R b4 、S(O)NR c4 R d4 、S(O)2R b4 、S(O)2NR c4 R d4 and BR h4 R i4 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0146] R 5 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a5 SR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 C(O)R b5 NR c5 C(O)OR a5 NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NOR a5 )R b5 、C(=NR e5 )NR c5 Rd5 NR c5 C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )R b5 NR c5 S(O)R b5 NR c5 S(O)2R b5 NR c5 S(O)2NR c5 R d5 、S(O)R b5 、S(O)NR c5 R d5 、S(O)2R b5 、S(O)2NR c5 R d5 and BR h5 R i5 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted;

[0147] When R 4 R 5 C YR 6 is a double bond and Y is N, then R 4 and R 6 does not exist;

[0148] When R 4 R 5 C YR 6 is a double bond and Y is C, then R 4 does not exist; and

[0149] R 6 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a6 SR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 NR c6 R d6 NR c6 C(O)R b6 NR c6 C(O)OR a6 NR c6 C(O)NR c6 R d6 、C(=NR e6 )R b6 、C(=NOR a6 )R b6 、C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )R b6 NR c6 S(O)R b6 NR c6 S(O)2R b6 NR c6 S(O)2NR c6 R d6 、S(O)R b6 、S(O)NR c6 R d6 、S(O)2R b6 、S(O)2NR c6 R d6 and BR h6 R i6wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 60 Substituents substituted;

[0150] R 7 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a7 SR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NOR a7 )R b7 、C(=NR e7 )NR c7 Rd7 NR c7 C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )R b7 NR c7 S(O)R b7 NR c7 S(O)2R b7 NR c7 S(O)2NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O)2R b7 、S(O)2NR c7 R d7 and BR h7 R i7 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 70 Substituents substituted;

[0151] Cy 2 Selected from C 3-10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6-10 wherein the 4-14 membered heterocycloalkyl and the 5-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-14 membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl; and wherein the C 3-10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 20 Substituents substituted;

[0152] Each R10 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a10 SR a10 、C(O)R b10 、C(O)NR c10 R d10 、C(O)OR a10 、OC(O)R b10 、OC(O)NR c10 R d10 NR c10 R d10 NR c10 C(O)R b10 NR c10 C(O)OR a10 NR c10 C(O)NR c10 R d10 、C(=NR e10 )R b10 、C(=NOR a10 )R b10 、C(=NR e10 )NR c10 R d10 NR c10 C(=NR e10 )NR c10 R d10 NR c10 S(O)R b10 NR c10 S(O)2R b10 NR c10 S(O)2NR c10 R d10 、S(O)R b10 、S(O)NR c10 R d10 、S(O)2R b10 、S(O)2NR c10 R d10 and BRh10 R i10 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 11 Substituents substituted;

[0153] Each R 11 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a11 SR a11 、C(O)R b11 、C(O)NR c11 R d11 、C(O)OR a11 、OC(O)R b11 、OC(O)NR c11 R d11 NR c11 R d11 NR c11 C(O)R b11 NR c11 C(O)OR a11 NR c11 C(O)NR c11 R d11 NR c11 S(O)R b11 NR c11 S(O)2R b11 NR c11S(O)2NR c11 R d11 、S(O)R b11 、S(O)NR c11 R d11 、S(O)2R b11 、S(O)2NR c11 R d11 and BR h11 R i11 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 12 Substituents substituted;

[0154] Each R 12 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a12 SR a12 、C(O)R b12 、C(O)NR c12 R d12 、C(O)OR a12 、OC(O)R b12 、OC(O)NR c12 R d12 NR c12 R d12 NR c12 C(O)R b12 NR c12 C(O)OR a12 NR c12 C(O)NR c12 R d12 NR c12 S(O)R b12 NR c12 S(O)2R b12 NR c12S(O)2NR c12 R d12 、S(O)R b12 、S(O)NR c12 R d12 、S(O)2R b12 、S(O)2NR c12 R d12 and BR h12 R i12 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0155] Each R 20 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a20 SR a20 、C(O)R b20 、C(O)NR c20 R d20 、C(O)OR a20 、OC(O)R b20 、OC(O)NR c20 R d20 NR c20 R d20 NR c20 C(O)R b20 NR c20 C(O)OR a20 NR c20 C(O)NR c20 R d20 、C(=NR e20 )R b20 、C(=NOR a20 )R b20 、C(=NRe20 )NR c20 R d20 NR c20 C(=NR e20 )NR c20 R d20 NR c20 S(O)R b20 NR c20 S(O)2R b20 NR c20 S(O)2NR c20 R d20 、S(O)R b20 、S(O)NR c20 R d20 、S(O)2R b20 、S(O)2NR c20 R d20 and BR h20 R i20 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 21 Substituents substituted;

[0156] Each R 21 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a21 SR a21 、C(O)R b21 、C(O)NRc21 R d21 、C(O)OR a21 、OC(O)R b21 、OC(O)NR c21 R d21 NR c21 R d21 NR c21 C(O)R b21 NR c21 C(O)OR a21 NR c21 C(O)NR c21 R d21 NR c21 S(O)R b21 NR c21 S(O)2R b21 NR c21 S(O)2NR c21 R d21 、S(O)R b21 、S(O)NR c21 R d21 、S(O)2R b21 、S(O)2NR c21 R d21 and BR h21 R i21 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0157] Each R 22 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a22 SR a22 、C(O)R b22 、C(O)NR c22 R d22 、C(O)OR a22 、OC(O)R b22 、OC(O)NR c22 R d22 NR c22 R d22 NR c22 C(O)R b22 NR c22 C(O)OR a22 NR c22 C(O)NR c22 R d22 NR c22 S(O)R b22 NR c22 S(O)2R b22 NR c22 S(O)2NR c22 R d22 、S(O)R b22 、S(O)NR c22 R d22 、S(O)2R b22 、S(O)2NR c22 R d22 and BR h22 R i22 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 23 Substituents substituted;

[0158] Each R 23 Independently selected from C 1-6 Alkyl, C2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a23 SR a23 、C(O)R b23 、C(O)NR c23 R d23 、C(O)OR a23 、OC(O)R b23 、OC(O)NR c23 R d23 NR c23 R d23 NR c23 C(O)R b23 NR c23 C(O)OR a23 NR c23 C(O)NR c23 R d23 NR c23 S(O)R b23 NR c23 S(O)2R b23 NR c23 S(O)2NR c23 R d23 、S(O)R b23 、S(O)NR c23 R d23 、S(O)2R b23 、S(O)2NR c23 R d23 and BR h23 R i23 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 24 Substituents substituted;

[0159] Each R 24 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a24 SR a24 、C(O)R b24 、C(O)NR c24 R d24 、C(O)OR a24 、OC(O)R b24 、OC(O)NR c24 R d24 NR c24 R d24 NR c24 C(O)R b24 NR c24 C(O)OR a24 NR c24 C(O)NR c24 R d24 NR c24 S(O)R b24 NR c24 S(O)2R b24 NR c24 S(O)2NR c24 R d24 、S(O)R b24 、S(O)NR c24 R d24 、S(O)2R b24 、S(O)2NR c24 R d24 and BR h24 R i24 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0160] Each R 30 Independently selected from C 1-6Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a30 SR a30 、C(O)R b30 、C(O)NR c30 R d30 、C(O)OR a30 、OC(O)R b30 、OC(O)NR c30 R d30 NR c30 R d30 NR c30 C(O)R b30 NR c30 C(O)OR a30 NR c30 C(O)NR c30 R d30 NR c30 S(O)R b30 NR c30 S(O)2R b30 NR c30 S(O)2NR c30 R d30 、S(O)R b30 、S(O)NR c30 R d30 、S(O)2R b30 、S(O)2NR c30 R d30 and BR h30 R i30 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 Substituents substituted;

[0161] Each R 31 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a31 SR a31 、C(O)R b31 、C(O)NR c31 R d31 、C(O)OR a31 、OC(O)R b31 、OC(O)NR c31 R d31 NR c31 R d31 NR c31 C(O)R b31 NR c31 C(O)OR a31 NR c31 C(O)NR c31 R d31 NR c31 S(O)R b31 NR c31 S(O)2R b31 NR c31 S(O)2NR c31 R d31 、S(O)R b31 、S(O)NR c31 R d31 、S(O)2R b31 、S(O)2NR c31 R d31 and BR h31 R i31 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 32 Substituents substituted;

[0162] Each R 32 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a32 SR a32 、C(O)R b32 、C(O)NR c32 R d32 、C(O)OR a32 、OC(O)R b32 、OC(O)NR c32 R d32 NR c32 R d32 NR c32 C(O)R b32 NR c32 C(O)OR a32 NR c32 C(O)NR c32 R d32 NR c32 S(O)R b32 NR c32 S(O)2R b32 NR c32 S(O)2NR c32 R d32 、S(O)R b32 、S(O)NR c32 R d32 、S(O)2R b32 、S(O)2NR c32 R d32 and BR h32 R i32 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0163] Each R 50 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a50 SR a50 、C(O)R b50 、C(O)NR c50 R d50 、C(O)OR a50 、OC(O)R b50 、OC(O)NR c50 R d50 NR c50 R d50 NR c50 C(O)R b50 NR c50 C(O)OR a50 NR c50 C(O)NR c50 R d50 NR c50 S(O)R b50 NR c50 S(O)2R b50 NR c50 S(O)2NR c50 R d50 、S(O)R b50 、S(O)NR c50 R d50 、S(O)2R b50 、S(O)2NR c50 R d50 and BR h50 R i50 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 51 Substituents substituted;

[0164] Each R 51 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, C 6-10 Aryl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a51 SR a51 、C(O)R b51 、C(O)NR c51 R d51 、C(O)OR a51 、OC(O)R b51 、OC(O)NR c51 R d51 NR c51 R d51 NR c51 C(O)R b51 NR c51 C(O)OR a51 NR c51 C(O)NR c51 R d51 NR c51 S(O)R b51 NR c51 S(O)2R b51 NR c51 S(O)2NR c51 R d51 、S(O)R b51 、S(O)NR c51 R d51 、S(O)2R b51 、S(O)2NR c51 R d51 and BR h51 R i51 wherein said C 1-6 Alkyl, C2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 6-10 Aryl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 52 Substituents substituted;

[0165] Each R 52 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a52 SR a52 、C(O)R b52 、C(O)NR c52 R d52 、C(O)OR a52 、OC(O)R b52 、OC(O)NR c52 R d52 NR c52 R d52 NR c52 C(O)R b52 NR c52 C(O)OR a52 NR c52 C(O)NR c52 R d52 NR c52 S(O)R b52 NR c52 S(O)2R b52 NR c52 S(O)2NR c52 R d52 、S(O)R b52 、S(O)NR c52 R d52 、S(O)2R b52 、S(O)2NR c52 R d52 and BR h52 R i52 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0166] Each R 60 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a60 SR a60 、C(O)R b60 、C(O)NR c60 R d60 、C(O)OR a60 、OC(O)R b60 、OC(O)NR c60 R d60 NR c60 R d60 NR c60 C(O)R b60 NR c60 C(O)OR a60 NR c60 C(O)NR c60 R d60 NR c60 S(O)R b60 NR c60 S(O)2R b60 NR c60 S(O)2NR c60 R d60 、S(O)R b60 、S(O)NR c60 R d60 、S(O)2R b60 、S(O)2NR c60 R d60 and BR h60 R i60 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 61 Substituents substituted;

[0167] Each R 61 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a61 SR a61 、C(O)R b61 、C(O)NR c61 R d61 、C(O)OR a61 、OC(O)R b61 、OC(O)NR c61 R d61 NR c61 R d61 NR c61 C(O)R b61 NR c61 C(O)OR a61 NR c61 C(O)NR c61 R d61 NR c61 S(O)R b61 NR c61 S(O)2R b61 NR c61 S(O)2NR c61 R d61 、S(O)R b61 、S(O)NR c61 R d61 、S(O)2R b61 、S(O)2NR c61 R d61 and BR h61 R i61wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 62 Substituents substituted;

[0168] Each R 62 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a62 SR a62 、C(O)R b62 、C(O)NR c62 R d62 、C(O)OR a62 、OC(O)R b62 、OC(O)NR c62 R d62 NR c62 R d62 NR c62 C(O)R b62 NR c62 C(O)OR a62 NR c62 C(O)NR c62 R d62 NR c62 S(O)R b62 NR c62 S(O)2R b62 NR c62 S(O)2NR c62 R d62 、S(O)R b62 、S(O)NR c62 R d62 、S(O)2R b62 、S(O)2NR c62 R d62 and BR h62 R i62wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0169] Each R 70 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a70 SR a70 、C(O)R b70 、C(O)NR c70 R d70 、C(O)OR a70 、OC(O)R b70 、OC(O)NR c70 R d70 NR c70 R d70 NR c70 C(O)R b70 NR c70 C(O)OR a70 NR c70 C(O)NR c70 R d70 NR c70 S(O)R b70 NR c70 S(O)2R b70 NR c70 S(O)2NR c70 R d70 、S(O)R b70 、S(O)NR c70 R d70 、S(O)2R b70 、S(O)2NR c70 R d70 and BR h70 Ri70 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 71 Substituents substituted;

[0170] Each R 71 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a71 SR a71 、C(O)R b71 、C(O)NR c71 R d71 、C(O)OR a71 、OC(O)R b71 、OC(O)NR c71 R d71 NR c71 R d71 NR c71 C(O)R b71 NR c71 C(O)OR a71 NR c71 C(O)NR c71 R d71 NR c71 S(O)R b71 NR c71 S(O)2R b71 NR c71 S(O)2NR c71R d71 、S(O)R b71 、S(O)NR c71 R d71 、S(O)2R b71 、S(O)2NR c71 R d71 and BR h71 R i71 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 72 Substituents substituted;

[0171] Each R 72 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a72 SR a72 、C(O)R b72 、C(O)NR c72 R d72 、C(O)OR a72 、OC(O)R b72 、OC(O)NR c72 R d72 NR c72 R d72 NR c72 C(O)R b72 NR c72 C(O)OR a72 NR c72 C(O)NR c72 R d72 NR c72 S(O)R b72 NR c72 S(O)2R b72 NR c72 S(O)2NR c72R d72 、S(O)R b72 、S(O)NR c72 R d72 、S(O)2R b72 、S(O)2NR c72 R d72 and BR h72 R i72 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0172] Each R a1 、R b1 、R c1 and R d1 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0173] or any R attached to the same N atom c1 and R d1 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R g a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0174] Each R h1 and R i1 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h1 and R i1 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0175] Each R a2 、R b2 、R c2 and R d2 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 22 Substituents substituted;

[0176] or any R attached to the same N atom c2 and R d2 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 22 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0177] Each R e2 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0178] Each R h2 and R i2 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h2 and R i2 Together with the B atom to which it is attached, it forms a1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0179] Each R a3 、R b3 、R c3 and R d3 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0180] or any R attached to the same N atom c3 and R d3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 30 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0181] Each R e3 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0182] Each R f3 and R j3 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0183] or any R attached to the same N atom c3 and R j3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 30 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0184] Each R h3 and R i3 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h3 and R i3 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0185] Each R a4 、R b4 、R c4 and R d4 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0186] or any R attached to the same N atom c4 and R d4Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R g a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0187] Each R h4 and R i4 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h4 and R i4 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0188] Each R a5 、R b5 、R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted;

[0189] or any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 50 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0190] Each R e5 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0191] Each R h5 and R i5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h5 and R i5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0192] Each R a6 、R b6 、R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 60 Substituents substituted;

[0193] or any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 60 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0194] Each R e6 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0195] Each R h6 and R i6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h6 and R i6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0196] Each R a7 、R b7 、R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 70 Substituents substituted;

[0197] or any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 70 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0198] Each R e7 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0199] Each R h7 and R i7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h7 and R i7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0200] Each R a10 、R b10 、R c10 and R d10 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 11 Substituents substituted;

[0201] or any R attached to the same N atom c10 and R d10 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 11 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0202] Each R e10 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0203] Each R h10 and R i10 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h10 and R i10 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0204] Each R a11 、R b11 、R c11 and R d11 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 12 Substituents substituted;

[0205] or any R attached to the same N atom c11 and R d11 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 12 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0206] Each R h11 and R i11 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h11 and Ri11 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0207] Each R a12 、R b12 、R c12 and R d12 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0208] Each R h12 and R i12 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h12 and R i12 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0209] Each R a20 、R b20 、R c20 and R d20 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 21 Substituents substituted;

[0210] or any R attached to the same N atom c20 and Rd20 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 21 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0211] Each R e20 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0212] Each R h20 and R i20 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h20 and R i20 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0213] Each R a21 、R b21 、R c21 and R d21 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0214] or any R attached to the same N atom c21 and Rd21 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R g a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0215] Each R h21 and R i21 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h21 and R i21 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0216] Each R a22 、R b22 、R c22 and R d22 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 23 Substituents substituted;

[0217] or any R attached to the same N atom c22 and R d22 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 23 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0218] Each R h22 and R i22 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h22 and R i22 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0219] Each R a23 、R b23 、R c23 and R d23 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 24 Substituents substituted;

[0220] or any R attached to the same N atom c23 and R d23 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 24 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0221] Each R h23 and R i23 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h23 and R i23 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0222] Each R a24 、R b24 、R c24 and R d24 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0223] Each R h24 and R i24 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h24 and R i24 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0224] Each R a30 、R b30 、R c30 and R d30 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 Substituents substituted;

[0225] or any R attached to the same N atom c30 and R d30 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 31 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0226] Each R h30 and R i30 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h30 and R i30 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0227] Each R a31 、R b31 、Rc31 and R d31 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 32 Substituents substituted;

[0228] or any R attached to the same N atom c31 and R d31 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 32 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0229] Each R h31 and R i31 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h31 and R i31 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0230] Each R a32 、R b32 、R c32 and R d32 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0231] Each R h32 and R i32 Independently selected from OH, C 1-6 Alkoxy and C 1-6or any R attached to the same B atom h32 and R i32 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0232] Each R a50 、R b50 、R c50 and R d50 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 51 Substituents substituted;

[0233] or any R attached to the same N atom c50 and R d50 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 51 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0234] Each R h50 and R i50 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h50 and R i50 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0235] Each R a51 、R b51 、R c51 and R d51 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 52 Substituents substituted;

[0236] or any R attached to the same N atom c51 and R d51 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 52 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0237] Each R h51 and R i51 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h51 and R i51 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0238] Each R a52 、R b52 、R c52 and R d52 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0239] Each R h52 and R i52 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h52 and R i52 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0240] Each R a60 、R b60 、R c60 and R d60 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 61 Substituents substituted;

[0241] or any R attached to the same N atom c60 and R d60 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 61 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0242] Each R h60 and R i60 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h60 and R i60 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0243] Each R a61 、R b61 、R c61 and R d61 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 62 Substituents substituted;

[0244] or any R attached to the same N atom c61 and R d61 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 62 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0245] Each R h61 and R i61 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h61 and R i61 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0246] Each R a62 、R b62 、R c62 and R d62 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0247] or any R attached to the same N atom c62 and R d62 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R g a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0248] Each R h62 and R i62 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h62 and R i62Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0249] Each R a70 、R b70 、R c70 and R d70 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 71 Substituents substituted;

[0250] or any R attached to the same N atom c70 and R d70 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 71 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0251] Each R h70 and R i70 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h70 and R i70 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0252] Each R a71 、R b71 、R c71 and R d71 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 72 Substituents substituted;

[0253] or any R attached to the same N atom c71 and R d71 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 72 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0254] Each R h71 and R i71 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h71 and R i71 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0255] Each R a72 、R b72 、R c72 and R d72 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0256] Each R h72 and R i72 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h72 and R i72 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group; and

[0257] Each R g Independently selected from D, OH, NO2, CN halogenated, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-2 Alkylene, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 1-3 Alkoxy-C 1-3 Alkyl, C 1-3 Alkoxy-C 1-3 Alkoxy, HO-C 1-3 Alkoxy, HO-C 1-3 Alkyl, cyano-C 1-3 Alkyl, H2N-C 1-3 Alkyl, amino, C 1-6 Alkylamino, di(C 1-6 alkyl)amino, thio, C 1-6 Alkylthio, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, carboxyl, C 1-6 Alkylcarbonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylcarbonylamino, C 1-6 Alkoxycarbonylamino, C 1-6 Alkylcarbonyloxy, aminocarbonyloxy, C 1-6 Alkylaminocarbonyloxy, di(C 1-6 alkyl)aminocarbonyloxy, C 1-6 Alkylsulfonylamino, aminosulfonyl, C 1-6 Alkylaminosulfonyl, di(C 1-6 alkyl)aminosulfonyl, aminosulfonylamino, C 1-6 Alkylaminosulfonylamino, di(C 1-6 alkyl)aminosulfonylamino, aminocarbonylamino, C 1-6 Alkylaminocarbonylamino and di(C 1-6 alkyl)aminocarbonylamino;

[0258] The condition is that when R 4 R 5 C YR 6 is a double bond and Y is N, then Cy 1Not 3,5-dimethylisoxazol-4-yl.

[0259] In one embodiment of Formula I or a pharmaceutically acceptable salt thereof,

[0260] each independently represents a single bond or a double bond;

[0261] X is N or CR 7 ;

[0262] Y is N or C;

[0263] R 1 Selected from H, D, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, CN, OR a1 SR a1 、C(O)R b1 、C(O)NR c1 R d1 、C(O)OR a1 、OC(O)R b1 、OC(O)NR c1 R d1 NR c1 R d1 NR c1 C(O)R b1 NR c1 C(O)OR a1 NR c1 C(O)NR c1 R d1 NR c1 S(O)R b1 NR c1 S(O)2R b1 NR c1 S(O)2NR c1 R d1 、S(O)R b1 、S(O)NR c1 R d1 、S(O)2R b1 、S(O)2NR c1 R d1 and BR h1 R i1 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0264] R 2 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a2 SR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 NR c2 R d2 NR c2 C(O)R b2 NR c2 C(O)OR a2 NR c2 C(O)NR c2 R d2 、C(=NR e2 )R b2 、C(=NOR a2 )R b2 、C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )R b2 NR c2 S(O)R b2 NR c2 S(O)2R b2NR c2 S(O)2NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O)2R b2 、S(O)2NR c2 R d2 and BR h2 R i2 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 22 Substituents substituted;

[0265] Cy 1 Selected from C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 wherein the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl; and wherein the C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 independently selected R 10 Substituents substituted;

[0266] R 3 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR f3 SR a3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 NR c3 R j3 NR c3 C(O)R b3 NR c3 C(O)OR a3 NR c3 C(O)NR c3 R d3 、C(=NR e3 )R b3 、C(=NOR a3 )R b3 、C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )R b3 NR c3 S(O)R b3 NR c3 S(O)2R b3 NR c3 S(O)2NR c3 R d3 、S(O)R b3 、S(O)NR c3 R d3 、S(O)2R b3 、S(O)2NR c3 R d3 and BR h3 R i3 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0267] When R 4 R 5 C YR 6 is a single bond and Y is C, then YR 6 is selected from C═O and C═S; and

[0268] R 4 Selected from H, D, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, CN, OR a4 SR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 NR c4 R d4 NR c4 C(O)R b4 NR c4 C(O)OR a4 NR c4 C(O)NR c4 R d4 NR c4 S(O)R b4 NR c4 S(O)2R b4 NR c4 S(O)2NR c4 R d4 、S(O)R b4 、S(O)NR c4 R d4 、S(O)2R b4 、S(O)2NR c4 R d4 and BR h4 Ri4 ;

[0269] R 5 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a5 SR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 C(O)R b5 NR c5 C(O)OR a5 NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NOR a5 )R b5 、C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )R b5 NR c5 S(O)R b5 NR c5 S(O)2R b5 NR c5 S(O)2NR c5 R d5 、S(O)R b5 、S(O)NRc5 R d5 、S(O)2R b5 、S(O)2NR c5 R d5 and BR h5 R i5 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted;

[0270] When R 4 R 5 C YR 6 is a double bond and Y is N, then R 4 and R 6 does not exist;

[0271] When R 4 R 5 C YR 6 is a double bond and Y is C, then R 4 does not exist; and

[0272] R 6 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a6 SR a6 、C(O)R b6 、C(O)NRc6 R d6 、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 NR c6 R d6 NR c6 C(O)R b6 NR c6 C(O)OR a6 NR c6 C(O)NR c6 R d6 、C(=NR e6 )R b6 、C(=NOR a6 )R b6 、C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )R b6 NR c6 S(O)R b6 NR c6 S(O)2R b6 NR c6 S(O)2NR c6 R d6 、S(O)R b6 、S(O)NR c6 R d6 、S(O)2R b6 、S(O)2NR c6 R d6 and BR h6 R i6 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R60 Substituents substituted;

[0273] R 7 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a7 SR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NOR a7 )R b7 、C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )R b7 NR c7 S(O)R b7 NR c7 S(O)2R b7 NR c7 S(O)2NR c7 R d7 、S(O)R b7、S(O)NR c7 R d7 、S(O)2R b7 、S(O)2NR c7 R d7 and BR h7 R i7 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 70 Substituents substituted;

[0274] Cy 2 Selected from C 3-10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6-10 wherein the 4-14 membered heterocycloalkyl and the 5-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-14 membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl; and wherein the C 3-10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 20 Substituents substituted;

[0275] Each R 10 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3Alkylene, halo, D, CN, NO2, OR a10 SR a10 、C(O)R b10 、C(O)NR c10 R d10 、C(O)OR a10 、OC(O)R b10 、OC(O)NR c10 R d10 NR c10 R d10 NR c10 C(O)R b10 NR c10 C(O)OR a10 NR c10 C(O)NR c10 R d10 、C(=NR e10 )R b10 、C(=NOR a10 )R b10 、C(=NR e10 )NR c10 R d10 NR c10 C(=NR e10 )NR c10 R d10 NR c10 S(O)R b10 NR c10 S(O)2R b10 NR c10 S(O)2NR c10 R d10 、S(O)R b10 、S(O)NR c10 R d10 、S(O)2R b10 、S(O)2NR c10 R d10 and BR h10 R i10 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 11 Substituents substituted;

[0276] Each R 11 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a11 SR a11 、C(O)R b11 、C(O)NR c11 R d11 、C(O)OR a11 、OC(O)R b11 、OC(O)NR c11 R d11 NR c11 R d11 NR c11 C(O)R b11 NR c11 C(O)OR a11 NR c11 C(O)NR c11 R d11 NR c11 S(O)R b11 NR c11 S(O)2R b11 NR c11 S(O)2NR c11 R d11 、S(O)R b11 、S(O)NR c11 R d11 、S(O)2R b11 、S(O)2NR c11 R d11 and BR h11 R i11 ;

[0277] Each R 20 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a20 SR a20 、C(O)R b20 、C(O)NR c20 R d20 、C(O)OR a20 、OC(O)R b20 、OC(O)NR c20 R d20 NR c20 R d20 NR c20 C(O)R b20 NR c20 C(O)OR a20 NR c20 C(O)NR c20 R d20 、C(=NR e20 )R b20 、C(=NOR a20 )R b20 、C(=NR e20 )NR c20 R d20 NR c20 C(=NR e20 )NR c20 R d20 NR c20 S(O)R b20 NR c20 S(O)2R b20 NR c20 S(O)2NR c20 R d20 、S(O)R b20 、S(O)NR c20 R d20 、S(O)2R b20 、S(O)2NR c20 R d20 and BR h20 R i20 wherein said C 1-6 Alkyl, C2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 21 Substituents substituted;

[0278] Each R 21 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a21 SR a21 、C(O)R b21 、C(O)NR c21 R d21 、C(O)OR a21 、OC(O)R b21 、OC(O)NR c21 R d21 NR c21 R d21 NR c21 C(O)R b21 NR c21 C(O)OR a21 NR c21 C(O)NR c21 R d21 NR c21 S(O)R b21 NR c21 S(O)2R b21 NR c21 S(O)2NR c21 R d21 、S(O)R b21、S(O)NR c21 R d21 、S(O)2R b21 、S(O)2NR c21 R d21 and BR h21 R i21 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0279] Each R 22 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a22 SR a22 、C(O)R b22 、C(O)NR c22 R d22 、C(O)OR a22 、OC(O)R b22 、OC(O)NR c22 R d22 NR c22 R d22 NR c22 C(O)R b22 NR c22 C(O)OR a22 NR c22 C(O)NR c22 Rd22 NR c22 S(O)R b22 NR c22 S(O)2R b22 NR c22 S(O)2NR c22 R d22 、S(O)R b22 、S(O)NR c22 R d22 、S(O)2R b22 、S(O)2NR c22 R d22 and BR h22 R i22 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 23 Substituents substituted;

[0280] Each R 23 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a23 SR a23 、C(O)R b23 、C(O)NR c23 R d23 、C(O)OR a23 、OC(O)R b23 、OC(O)NR c23 Rd23 NR c23 R d23 NR c23 C(O)R b23 NR c23 C(O)OR a23 NR c23 C(O)NR c23 R d23 NR c23 S(O)R b23 NR c23 S(O)2R b23 NR c23 S(O)2NR c23 R d23 、S(O)R b23 、S(O)NR c23 R d23 、S(O)2R b23 、S(O)2NR c23 R d23 and BR h23 R i23 ;

[0281] Each R 30 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a30 SR a30 、C(O)R b30 、C(O)NR c30 R d30 、C(O)OR a30 、OC(O)R b30 、OC(O)NR c30 R d30 NR c30 R d30 NR c30 C(O)R b30 NR c30 C(O)OR a30 NR c30C(O)NR c30 R d30 NR c30 S(O)R b30 NR c30 S(O)2R b30 NR c30 S(O)2NR c30 R d30 、S(O)R b30 、S(O)NR c30 R d30 、S(O)2R b30 、S(O)2NR c30 R d30 and BR h30 R i30 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 Substituents substituted;

[0282] Each R 31 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a31 SR a31 、C(O)R b31 、C(O)NR c31 R d31 、C(O)OR a31 、OC(O)R b31 、OC(O)NRc31 R d31 NR c31 R d31 NR c31 C(O)R b31 NR c31 C(O)OR a31 NR c31 C(O)NR c31 R d31 NR c31 S(O)R b31 NR c31 S(O)2R b31 NR c31 S(O)2NR c31 R d31 、S(O)R b31 、S(O)NR c31 R d31 、S(O)2R b31 、S(O)2NR c31 R d31 and BR h31 R i31 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 32 Substituents substituted;

[0283] Each R 32 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a32 SR a32 、C(O)R b32 、C(O)NR c32 R d32 、C(O)OR a32 、OC(O)R b32 、OC(O)NRc32 R d32 NR c32 R d32 NR c32 C(O)R b32 NR c32 C(O)OR a32 NR c32 C(O)NR c32 R d32 NR c32 S(O)R b32 NR c32 S(O)2R b32 NR c32 S(O)2NR c32 R d32 、S(O)R b32 、S(O)NR c32 R d32 、S(O)2R b32 、S(O)2NR c32 R d32 and BR h32 R i32 ;

[0284] Each R 50 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a50 SR a50 、C(O)R b50 、C(O)NR c50 R d50 、C(O)OR a50 、OC(O)R b50 、OC(O)NR c50 R d50 NR c50 R d50 NR c50 C(O)R b50 NR c50 C(O)OR a50 NRc50 C(O)NR c50 R d50 NR c50 S(O)R b50 NR c50 S(O)2R b50 NR c50 S(O)2NR c50 R d50 、S(O)R b50 、S(O)NR c50 R d50 、S(O)2R b50 、S(O)2NR c50 R d50 and BR h50 R i50 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 51 Substituents substituted;

[0285] Each R 51 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, C 6-10 Aryl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a51 SR a51 、C(O)R b51 、C(O)NR c51 R d51 、C(O)OR a51 、OC(O)R b51 、OC(O)NR c51 R d51 NR c51 R d51 NR c51 C(O)R b51 NR c51 C(O)ORa51 NR c51 C(O)NR c51 R d51 NR c51 S(O)R b51 NR c51 S(O)2R b51 NR c51 S(O)2NR c51 R d51 、S(O)R b51 、S(O)NR c51 R d51 、S(O)2R b51 、S(O)2NR c51 R d51 and BR h51 R i51 ;

[0286] Each R 60 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a60 SR a60 、C(O)R b60 、C(O)NR c60 R d60 、C(O)OR a60 、OC(O)R b60 、OC(O)NR c60 R d60 NR c60 R d60 NR c60 C(O)R b60 NR c60 C(O)OR a60 NR c60 C(O)NR c60 R d60 NR c60 S(O)R b60 NR c60 S(O)2R b60NR c60 S(O)2NR c60 R d60 、S(O)R b60 、S(O)NR c60 R d60 、S(O)2R b60 、S(O)2NR c60 R d60 and BR h60 R i60 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 61 Substituents substituted;

[0287] Each R 61 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a61 SR a61 、C(O)R b61 、C(O)NR c61 R d61 、C(O)OR a61 、OC(O)R b61 、OC(O)NR c61 R d61 NR c61 R d61 NR c61 C(O)R b61 NRc61 C(O)OR a61 NR c61 C(O)NR c61 R d61 NR c61 S(O)R b61 NR c61 S(O)2R b61 NR c61 S(O)2NR c61 R d61 、S(O)R b61 、S(O)NR c61 R d61 、S(O)2R b61 、S(O)2NR c61 R d61 and BR h61 R i61 ;

[0288] Each R 70 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, NO2, OR a70 SR a70 、C(O)R b70 、C(O)NR c70 R d70 、C(O)OR a70 、OC(O)R b70 、OC(O)NR c70 R d70 NR c70 R d70 NR c70 C(O)R b70 NR c70 C(O)OR a70 NR c70 C(O)NR c70 R d70 NR c70 S(O)R b70 NR c70S(O)2R b70 NR c70 S(O)2NR c70 R d70 、S(O)R b70 、S(O)NR c70 R d70 、S(O)2R b70 、S(O)2NR c70 R d70 and BR h70 R i70 ;

[0289] Each R a1 、R b1 、R c1 and R d1 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0290] or any R attached to the same N atom c1 and R d1 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R g a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0291] Each R h1 and R i1 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h1 and R i1 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0292] Each R a2 、R b2 、R c2and R d2 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 22 Substituents substituted;

[0293] or any R attached to the same N atom c2 and R d2 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 22 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0294] Each R e2 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0295] Each R h2 and R i2 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h2 and R i2 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0296] Each R a3 、Rb3 、R c3 and R d3 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0297] or any R attached to the same N atom c3 and R d3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 30 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0298] Each R e3 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0299] Each R f3 and R j3 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0300] or any R attached to the same N atom c3 and R j3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 30 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0301] Each R h3 and R i3 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h3 and R i3 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0302] Each R a4 、R b4 、R c4 and R d4 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0303] or any R attached to the same N atom c4 and R d4 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R g a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0304] Each R h4 and R i4Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h4 and R i4 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0305] Each R a5 、R b5 、R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted;

[0306] or any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 50 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0307] Each R e5 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0308] Each Rh5 and R i5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h5 and R i5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0309] Each R a6 、R b6 、R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 60 Substituents substituted;

[0310] or any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 60 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0311] Each R e6 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0312] Each R h6 and R i6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h6 and R i6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0313] Each R a7 、R b7 、R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 70 Substituents substituted;

[0314] or any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 70 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0315] Each R e7 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0316] Each R h7 and R i7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h7 and R i7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0317] Each R a10 、R b10 、R c10 and R d10 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 11 Substituents substituted;

[0318] or any R attached to the same N atom c10 and R d10 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 11 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0319] Each R e10 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0320] Each R h10 and R i10 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h10 and R i10 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0321] Each R a11 、R b11 、R c11 and R d11 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl;

[0322] or any R attached to the same N atom c11 and R d11 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group;

[0323] Each R h11 and R i11 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h11 and R i11 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0324] Each R a20 、R b20 、R c20 and R d20 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 21 Substituents substituted;

[0325] or any R attached to the same N atom c20 and R d20 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 21 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0326] Each R e20 Independently selected from H, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 1-6 Alkylthio, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbonyl, C 1-6 Alkylaminosulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl and di(C 1-6 alkyl)aminosulfonyl;

[0327] Each R h20 and R i20 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h20 and R i20 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0328] Each R a21 、R b21 、R c21 and R d21 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R g Substituents substituted;

[0329] or any R attached to the same N atom c21 and R d21 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R g a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0330] Each R h21 and R i21 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h21 and R i21 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0331] Each R a22 、R b22 、R c22 and R d22 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 23 Substituents substituted;

[0332] or any R attached to the same N atom c22 and R d22 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 23a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0333] Each R h22 and R i22 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h22 and R i22 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0334] Each R a23 、R b23 、R c23 and R d23 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl;

[0335] or any R attached to the same N atom c23 and R d23 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group;

[0336] Each R h23 and R i23 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h23 and R i23 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0337] Each R a30 、R b30 、R c30 and R d30 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 Substituents substituted;

[0338] or any R attached to the same N atom c30 and R d30 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 31 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0339] Each R h30 and R i30 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h30 and R i30 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0340] Each R a31 、R b31 、R c31 and R d31 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 32 Substituents substituted;

[0341] or any R attached to the same N atom c31 and R d31 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 32 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0342] Each Rh31 and R i31 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h31 and R i31 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0343] Each R a32 、R b32 、R c32 and R d32 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 alkyl halide;

[0344] Each R h32 and R i32 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h32 and R i32 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0345] Each R a50 、R b50 、R c50 and R d50 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 51 Substituents substituted;

[0346] or any R attached to the same N atom c50and R d50 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 51 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0347] Each R h50 and R i50 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h50 and R i50 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0348] Each R a51 、R b51 、R c51 and R d51 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl;

[0349] or any R attached to the same N atom c51 and R d51 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group;

[0350] Each R h51 and R i51 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h51 and R i51 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0351] Each R a60 、R b60 、R c60 and R d60 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 61 Substituents substituted;

[0352] or any R attached to the same N atom c60 and R d60 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 61 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0353] Each R h60 and R i60 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h60 and R i60 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0354] Each R a61 、R b61 、R c61 and R d61 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl;

[0355] or any R attached to the same N atom c61 and R d61 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group;

[0356] Each R h61 and R i61 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h61 and R i61Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0357] Each R a70 、R b70 、R c70 and R d70 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl;

[0358] or any R attached to the same N atom c70 and R d70 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group;

[0359] Each R h70 and R i70 Independently selected from OH, C 1-6 Alkoxy and C 1-6 or any R attached to the same B atom h70 and R i70 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 a 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group; and

[0360] Each R g Independently selected from D, OH, NO2, CN, halo, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-2 Alkylene, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 1-3 Alkoxy-C 1-3 Alkyl, C 1-3 Alkoxy-C 1-3 Alkoxy, HO-C 1-3 Alkoxy, HO-C 1-3 Alkyl, cyano-C 1-3 Alkyl, H2N-C 1-3Alkyl, amino, C 1-6 Alkylamino, di(C 1-6 alkyl)amino, thio, C 1-6 Alkylthio, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, carboxyl, C 1-6 Alkylcarbonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylcarbonylamino, C 1-6 Alkoxycarbonylamino, C 1-6 Alkylcarbonyloxy, aminocarbonyloxy, C 1-6 Alkylaminocarbonyloxy, di(C 1-6 alkyl)aminocarbonyloxy, C 1-6 Alkylsulfonylamino, aminosulfonyl, C 1-6 Alkylaminosulfonyl, di(C 1-6 alkyl)aminosulfonyl, aminosulfonylamino, C 1-6 Alkylaminosulfonylamino, di(C 1-6 alkyl)aminosulfonylamino, aminocarbonylamino, C 1-6 Alkylaminocarbonylamino and di(C 1-6 alkyl)aminocarbonylamino.

[0361] In another embodiment, the compound of Formula I is a compound of Formula Ia:

[0362]

[0363] or a pharmaceutically acceptable salt thereof,

[0364] in:

[0365] Y is N or C;

[0366] R 1 Selected from H, D, C 1-6 Alkyl, C 1-6 haloalkyl, halo, and CN;

[0367] R 2 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a2 SR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 NR c2 R d2 NR c2 C(O)R b2 NR c2 C(O)OR a2 NR c2 C(O)NR c2 R d2 NR c2 S(O)2R b2 NR c2 S(O)2NR c2 R d2 、S(O)2R b2 and S(O)2NR c2 R d2 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 22 Substituents substituted;

[0368] Cy 1 Selected from C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10wherein the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl; and wherein the C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 independently selected R 10 Substituents substituted;

[0369] R 3 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR f3 SR a3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 NR c3 R j3 NR c3 C(O)R b3 NR c3 C(O)OR a3 NR c3 C(O)NR c3 R d3 NR c3 S(O)2R b3 NR c3 S(O)2NR c3 R d3 、S(O)2R b3 and S(O)2NR c3 R d3 wherein said C 1-6 Alkyl, C2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0370] R 5 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a5 SR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 C(O)R b5 NR c5 C(O)OR a5 NR c5 C(O)NR c5 R d5 NR c5 S(O)2R b5 NR c5 S(O)2NR c5 R d5 、S(O)2R b5 and S(O)2NR c5 R d5wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted;

[0371] When R 4 R 5 C YR 6 is a double bond and Y is N, then R 4 and R 6 does not exist;

[0372] When R 4 R 5 C YR 6 is a double bond and Y is C, then R 4 does not exist; and

[0373] R 6 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a6 SR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 NR c6 Rd6 NR c6 C(O)R b6 NR c6 C(O)OR a6 NR c6 C(O)NR c6 R d6 NR c6 S(O)2R b6 NR c6 S(O)2NR c6 R d6 、S(O)2R b6 and S(O)2NR c6 R d6 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 60 Substituents substituted;

[0374] R 7 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a7 SR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 Rd7 NR c7 R d7 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 NR c7 S(O)2R b7 NR c7 S(O)2NR c7 R d7 、S(O)2R b7 and S(O)2NR c7 R d7 ;

[0375] Cy 2 Selected from C 3-10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6-10 wherein the 4-14 membered heterocycloalkyl and the 5-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-14 membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl; and wherein the C 3-10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 20 Substituents substituted;

[0376] Each R 10 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a10 SR a10 、C(O)R b10 、C(O)NR c10 R d10、C(O)OR a10 、OC(O)R b10 、OC(O)NR c10 R d10 NR c10 R d10 NR c10 C(O)R b10 NR c10 C(O)OR a10 NR c10 C(O)NR c10 R d10 NR c10 S(O)2R b10 NR c10 S(O)2NR c10 R d10 、S(O)2R b10 and S(O)2NR c10 R d10 ;

[0377] Each R 20 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a20 SR a20 、C(O)R b20 、C(O)NR c20 R d20 、C(O)OR a20 、OC(O)R b20 、OC(O)NR c20 R d20 NR c20 R d20 NR c20 C(O)R b20 NR c20 C(O)OR a20 NR c20 C(O)NR c20 R d20 NR c20 S(O)2Rb20 NR c20 S(O)2NR c20 R d20 、S(O)2R b20 and S(O)2NR c20 R d20 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 21 Substituents substituted;

[0378] Each R 21 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a21 SR a21 、C(O)R b21 、C(O)NR c21 R d21 、C(O)OR a21 、OC(O)R b21 、OC(O)NR c21 R d21 NR c21 R d21 NR c21 C(O)R b21 NR c21 C(O)OR a21 NR c21 C(O)NR c21 R d21NR c21 S(O)2R b21 NR c21 S(O)2NR c21 R d21 、S(O)2R b21 and S(O)2NR c21 R d21 ;

[0379] Each R 22 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a22 SR a22 、C(O)R b22 、C(O)NR c22 R d22 、C(O)OR a22 、OC(O)R b22 、OC(O)NR c22 R d22 NR c22 R d22 NR c22 C(O)R b22 NR c22 C(O)OR a22 NR c22 C(O)NR c22 R d22 NR c22 S(O)2R b22 NR c22 S(O)2NR c22 R d22 、S(O)2R b22 and S(O)2NR c22 R d22 ;

[0380] Each R 30 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a30 SR a30 、C(O)R b30 、C(O)NR c30 R d30 、C(O)OR a30 、OC(O)R b30 、OC(O)NR c30 R d30 NR c30 R d30 NR c30 C(O)R b30 NR c30 C(O)OR a30 NR c30 C(O)NR c30 R d30 NR c30 S(O)2R b30 NR c30 S(O)2NR c30 R d30 、S(O)2R b30 and S(O)2NR c30 R d30 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 Substituents substituted;

[0381] Each R 31 Independently selected from C 1-6 Alkyl, C 2-6Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a31 SR a31 、C(O)R b31 、C(O)NR c31 R d31 、C(O)OR a31 、OC(O)R b31 、OC(O)NR c31 R d31 NR c31 R d31 NR c31 C(O)R b31 NR c31 C(O)OR a31 NR c31 C(O)NR c31 R d31 NR c31 S(O)2R b31 NR c31 S(O)2NR c31 R d31 、S(O)2R b31 and S(O)2NR c31 R d31 ;

[0382] Each R 50 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a50 SRa50 、C(O)R b50 、C(O)NR c50 R d50 、C(O)OR a50 、OC(O)R b50 、OC(O)NR c50 R d50 NR c50 R d50 NR c50 C(O)R b50 NR c50 C(O)OR a50 NR c50 C(O)NR c50 R d50 NR c50 S(O)2R b50 NR c50 S(O)2NR c50 R d50 、S(O)2R b50 and S(O)2NR c50 R d50 ;

[0383] Each R 60 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR a60 SR a60 、C(O)R b60 、C(O)NR c60 R d60 、C(O)OR a60 、OC(O)R b60 、OC(O)NR c60 R d60 NR c60 R d60 NR c60 C(O)R b60 NR c60 C(O)OR a60 NRc60 C(O)NR c60 R d60 NR c60 S(O)2R b60 NR c60 S(O)2NR c60 R d60 、S(O)2R b60 and S(O)2NR c60 R d60 ;

[0384] Each R a2 、R b2 、R c2 and R d2 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 22 Substituents substituted;

[0385] or any R attached to the same N atom c2 and R d2 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 22 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0386] Each R a3 、R b3 、R c3 and R d3 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0387] or any R attached to the same N atom c3 and R d3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 30 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0388] Each R f3 and R j3 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0389] or any R attached to the same N atom c3 and R j3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 30 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0390] Each R a5 、R b5 、R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R50 Substituents substituted;

[0391] or any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 50 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0392] Each R a6 、R b6 、R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 60 Substituents substituted;

[0393] or any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 60 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0394] Each R a7 、R b7 、R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl;

[0395] or any R attached to the same N atom c7 and R d7 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group;

[0396] Each Ra10 、R b10 、R c10 and R d10 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl;

[0397] or any R attached to the same N atom c10 and R d10 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group;

[0398] Each R a20 、R b20 、R c20 and R d20 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 21 Substituents substituted;

[0399] or any R attached to the same N atom c20 and R d20 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 21 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0400] Each R a21 、R b21 、R c21 and R d21 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl;

[0401] or any R attached to the same N atom c21 and R d21 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group;

[0402] Each R a22 、R b22 、R c22 and R d22 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl;

[0403] or any R attached to the same N atom c22 and R d22 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group;

[0404] Each R a30 、R b30 、R c30 and R d30 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 Substituents substituted;

[0405] or any R attached to the same N atom c30 and R d30 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 31 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0406] Each R a31 、R b31 、R c31 and R d31 Independently selected from H, C 1-6Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl;

[0407] or any R attached to the same N atom c31 and R d31 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group;

[0408] Each R a50 、R b50 、R c50 and R d50 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl;

[0409] or any R attached to the same N atom c50 and R d50 Together with the nitrogen atom to which it is attached, it forms a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; and

[0410] Each R a60 、R b60 、R c60 and R d60 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl;

[0411] or any R attached to the same N atom c60 and R d60 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group.

[0412] In one embodiment of Formula Ia or a pharmaceutically acceptable salt thereof,

[0413] Y is N or C;

[0414] R 1 Selected from H, D and C 1-6 alkyl;

[0415] R 2Selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a2 and NR c2 R d2 wherein said C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 22 Substituents substituted;

[0416] Cy 1 Selected from C 6-10 wherein the 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the ring-forming carbon atoms of the 6-10 membered heteroaryl are optionally substituted with oxo to form a carbonyl; and wherein the C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 10 Substituents substituted;

[0417] R 3 Selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR f3 and NR c3 R j3 wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 30 Substituents substituted;

[0418] R 5 Selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a5 、C(O)NR c5 R d5 and NR c5 R d5 wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 50 Substituents substituted;

[0419] When R 4 R 5 C YR 6 is a double bond and Y is N, then R 4 and R 6 does not exist;

[0420] When R 4 R 5 C YR 6 is a double bond and Y is C, then R 4 does not exist; and

[0421] R 6 Selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a6 and NR c6 R d6 wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 60 Substituents substituted;

[0422] R 7 Selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, halo, D, and CN;

[0423] Cy 2 wherein the 4-10 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the ring-forming carbon atoms of the 4-10 membered heterocycloalkyl group are optionally substituted with oxo to form a carbonyl group; and wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2 or 3 groups independently selected from R 20 Substituents substituted;

[0424] Each R 10 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a10 and NR c10 R d10 ;

[0425] Each R 20 Independently selected from C1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a20 、C(O)R b20 、C(O)NR c20 R d20 and NR c20 R d20 wherein said C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2 or 3 groups independently selected from R 21 Substituents substituted;

[0426] Each R 21 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a21 and NR c21 R d21 ;

[0427] Each R 22 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a22 and NR c22 R d22 ;

[0428] Each R 30 Independently selected from C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 、C(O)NR c30 R d30 and NR c30 R d30 wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 31 Substituents substituted;

[0429] Each R 31 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a31 and NR c31 Rd31 ;

[0430] Each R 50 Independently selected from C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a50 and NR c50 R d50 ;

[0431] Each R 60 Independently selected from C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a60 、C(O)NR c60 R d60 、C(O)OR a60 and NR c60 R d60 ;

[0432] Each R a2 、R c2 and R d2 Independently selected from H, C 1-6 Alkyl and C 1-6 Haloalkyl; wherein the C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 22 Substituents substituted;

[0433] Each R c3 Independently selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 30 Substituents substituted;

[0434] Each R f3 and R j3 Independently selected from C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 30 Substituents substituted;

[0435] or any R attached to the same N atom c3 and R j3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 30 A 4-membered, 5-membered or 6-membered heterocycloalkyl group substituted with a substituent;

[0436] Each R a5 、R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 50 Substituents substituted;

[0437] or any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 50 A 4-membered, 5-membered or 6-membered heterocycloalkyl group substituted with a substituent;

[0438] Each R a6 、R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 60 Substituents substituted;

[0439] or any R attached to the same N atom c6 and Rd6 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 60 A 4-membered, 5-membered or 6-membered heterocycloalkyl group substituted with a substituent;

[0440] Each R a10 、R c10 and R d10 Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0441] Each R a20 、R b20 、R c20 and R d20 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2 or 3 groups independently selected from R 21 Substituents substituted;

[0442] Each R a21 、R c21 and R d21 Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0443] Each R a22 、R c22 and R d22 Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0444] Each R a30 、R c30 and R d30 Independently selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 31 Substituents substituted;

[0445] or any R attached to the same N atom c30 and R d30 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 31 A 4-membered, 5-membered or 6-membered heterocycloalkyl group substituted with a substituent;

[0446] Each R a31 、R c31 and R d31 Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0447] Each R a50 、R c50 and R d50 Independently selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl;

[0448] or any R attached to the same N atom c50 and R d50 Together with the nitrogen atom to which it is attached, it forms a 4-, 5-, or 6-membered heterocycloalkyl group; and

[0449] Each R a60 、R c60 and R d60 Independently selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl;

[0450] or any R attached to the same N atom c60 and R d60 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered or 6-membered heterocycloalkyl group.

[0451] In another embodiment of Formula Ia or a pharmaceutically acceptable salt thereof,

[0452] Y is N or C;

[0453] R 1 It is H;

[0454] R 2 Selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, halo, D, and CN;

[0455] Cy1 Selected from C 6-10 aryl and 6-10 membered heteroaryl; wherein the 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 10 Substituents substituted;

[0456] R 3 Selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, halo, D, CN, OR f3 and NR c3 R j3 wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl and 4-10 membered heterocycloalkyl are each optionally substituted by 1, 2 or 3 groups independently selected from R 30 Substituents substituted;

[0457] R 5 Selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, halo, D, and CN;

[0458] When R 4 R 5 C YR 6 is a double bond and Y is N, then R 6 does not exist;

[0459] R 6 Selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, halo, D, and CN;

[0460] R 7 Selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, halo, D, and CN;

[0461] Cy 2 wherein the 4-6 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the 4-6 membered heterocycloalkyl group is optionally substituted by 1, 2 or 3 ring-forming heteroatoms independently selected from R 20 Substituents substituted;

[0462] Each R 10 Independently selected from C 1-6 Alkyl, C 1-6Haloalkyl, halo, D, CN, OR a10 and NR c10 R d10 ;

[0463] Each R 20 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a20 、C(O)R b20 、C(O)NR c20 R d20 and NR c20 R d20 wherein said C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 21 Substituents substituted;

[0464] Each R 21 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a21 and NR c21 R d21 ;

[0465] Each R 30 Independently selected from C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 、C(O)NR c30 R d30 and NR c30 R d30 wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 31 Substituents substituted;

[0466] Each R 31 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a31 and NR c31 R d31 ;

[0467] Each R c3 Independently selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 30 Substituents substituted;

[0468] Each R f3 and R j3 Independently selected from C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 30 Substituents substituted;

[0469] or any R attached to the same N atom c3 and R j3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 30 A 4-membered, 5-membered or 6-membered heterocycloalkyl group substituted with a substituent;

[0470] Each R a10 、R c10 and R d10 Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0471] Each R a20 、R b20 、R c20 and R d20 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2 or 3 groups independently selected from R 21 Substituents substituted;

[0472] Each R a21 、R c21 and R d21Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0473] Each R a30 、R c30 and R d30 Independently selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 31 Substituents substituted;

[0474] or any R attached to the same N atom c30 and R d30 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2 or 3 independently selected R 31 a 4-membered, 5-membered or 6-membered heterocycloalkyl substituted with a substituent of

[0475] Each R a31 、R c31 and R d31 Independently selected from H, C 1-6 Alkyl and C 1-6 Halogenated alkyl.

[0476] In one embodiment,

[0477] Indicates a single bond or a double bond;

[0478] X is N or CR 7 ;

[0479] Y is N or C;

[0480] R 1 Selected from H, D, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, CN, OR a1 SR a1 、C(O)R b1 、C(O)NR c1 R d1 、C(O)OR a1 、OC(O)Rb1 、OC(O)NR c1 R d1 NR c1 R d1 NR c1 C(O)R b1 NR c1 C(O)OR a1 NR c1 C(O)NR c1 R d1 NR c1 S(O)2R b1 、S(O)2R b1 and S(O)2NR c1 R d1 wherein said C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0481] R 2 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a2 SR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 NR c2 R d2 NR c2 C(O)R b2 NR c2 C(O)OR a2 NR c2 C(O)NR c2 R d2 NR c2 S(O)2R b2 、S(O)2R b2 and S(O)2NR c2 R d2 wherein said C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R 22 Substituents substituted;

[0482] Cy 1 Selected from C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 wherein the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl; and wherein the C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 independently selected R 10 Substituents substituted;

[0483] R 3 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, halo, D, CN, OR f3 SR a3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 NR c3 R j3 NR c3 C(O)R b3 NR c3 C(O)OR a3 NR c3 C(O)NR c3 R d3 NR c3 S(O)2R b3 、S(O)2R b3 and S(O)2NR c3 Rd3 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0484] When R 4 R 5 C YR 6 is a single bond and Y is C, then YR 6 is selected from C═O and C═S; and

[0485] R 4 Selected from H, D, C 1-6 Alkyl and C 1-6 Haloalkyl; wherein the C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R g Substituents substituted;

[0486] R 5 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a5 SR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 C(O)R b5 NR c5 C(O)OR a5 NR c5 C(O)NRc5 R d5 NR c5 S(O)2R b5 、S(O)2R b5 and S(O)2NR c5 R d5 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted;

[0487] When R 4 R 5 C YR 6 is a double bond and Y is N, then R 4 and R 6 does not exist;

[0488] When R 4 R 5 C YR 6 is a double bond and Y is C, then R 4 does not exist; and

[0489] R 6 Selected from H, D, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, CN, OR a6 SR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 NR c6 R d6 NR c6 C(O)R b6 NR c6 C(O)OR a6 NR c6 C(O)NR c6 R d6 NR c6 S(O)2R b6、S(O)2R b6 and S(O)2NR c6 R d6 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 60 Substituents substituted;

[0490] R 7 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl, halo, D, CN, OR a7 SR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 NR c7 S(O)2R b7 、S(O)2R b7 and S(O)2NR c7 R d7 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 70 Substituents substituted;

[0491] Cy 2is a 4-14 membered heterocycloalkyl group; wherein the 4-14 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 4-14 membered heterocycloalkyl group are optionally substituted with oxo groups to form a carbonyl group; and wherein the 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3 or 4 ring-forming heteroatoms independently selected from R 20 Substituents substituted;

[0492] Each R 10 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a10 SR a10 、C(O)R b10 、C(O)NR c10 R d10 、C(O)OR a10 、OC(O)R b10 、OC(O)NR c10 R d10 NR c10 R d10 NR c10 C(O)R b10 NR c10 C(O)OR a10 NR c10 C(O)NR c10 R d10 NR c10 S(O)2R b10 、S(O)2R b10 and S(O)2NR c10 R d10 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 11 Substituents substituted;

[0493] Each R 11 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a11 SR a11 、CC(O)R b11 、C(O)NR c11 Rd11 、C(O)OR a11 、OC(O)R b11 、OC(O)NR c11 R d11 NR c11 R d11 NR c11 C(O)R b11 NR c11 C(O)OR a11 NR c11 C(O)NR c11 R d11 NR c11 S(O)2R b11 、S(O)2R b11 and S(O)2NR c11 R d11 ;

[0494] Each R 20 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a20 SR a20 、C(O)R b20 、C(O)NR c20 R d20 、C(O)OR a20 、OC(O)R b20 、OC(O)NR c20 R d20 NR c20 R d20 NR c20 C(O)R b20 NR c20 C(O)OR a20 NR c20 C(O)NR c20 R d20 NR c20 S(O)2R b20 、S(O)2R b20 and S(O)2NR c20 R d20 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 21 Substituents substituted;

[0495] Each R 21 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a21 SR a21 、C(O)R b21 、C(O)NR c21 R d21 、C(O)OR a21 、OC(O)R b21 、OC(O)NR c21 R d21 NR c21 R d21 NR c21 C(O)R b21 NR c21 C(O)OR a21 NR c21 C(O)NR c21 R d21 NR c21 S(O)2R b21 、S(O)2R b21 and S(O)2NR c21 R d21 ;

[0496] Each R 22 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a22 SR a22 、C(O)R b22 、C(O)NR c22 R d22 、C(O)OR a22 、OC(O)R b22 、OC(O)NR c22 R d22 NR c22 R d22 NR c22 C(O)R b22 NR c22 C(O)OR a22 NR c22 C(O)NR c22 R d22 NR c22 S(O)2R b22 、S(O)2Rb22 and S(O)2NR c22 R d22 ;

[0497] Each R 30 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 SR a30 、C(O)R b30 、C(O)NR c30 R d30 、C(O)OR a30 、OC(O)R b30 、OC(O)NR c30 R d30 NR c30 R d30 NR c30 C(O)R b30 NR c30 C(O)OR a30 NR c30 C(O)NR c30 R d30 NR c30 S(O)2R b30 、S(O)2R b30 and S(O)2NR c30 R d30 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 Substituents substituted;

[0498] Each R 31 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a31 SR a31 、C(O)R b31 、C(O)NR c31 Rd31 、C(O)OR a31 、OC(O)R b31 、OC(O)NR c31 R d31 NR c31 R d31 NR c31 C(O)R b31 NR c31 C(O)OR a31 NR c31 C(O)NR c31 R d31 NR c31 S(O)2R b31 、S(O)2R b31 and S(O)2NR c31 R d31 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 32 Substituents substituted;

[0499] Each R 32 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a32 SR a32 、C(O)R b32 、C(O)NR c32 R d32 、C(O)OR a32 、OC(O)R b32 、OC(O)NR c32 R d32 NR c32 R d32 NR c32 C(O)R b32 NR c32 C(O)OR a32 NR c32 C(O)NR c32 R d32 NR c32 S(O)2R b32 、S(O)2R b32 and S(O)2NR c32 R d32 ;

[0500] Each R50 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a50 SR a50 、C(O)R b50 、C(O)NR c50 R d50 、C(O)OR a50 、OC(O)R b50 、OC(O)NR c50 R d50 NR c50 R d50 NR c50 C(O)R b50 NR c50 C(O)OR a50 NR c50 C(O)NR c50 R d50 NR c50 S(O)2R b50 、S(O)2R b50 and S(O)2NR c50 R d50 ;

[0501] Each R 60 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a60 SR a60 、C(O)R b60 、C(O)NR c60 R d60 、C(O)OR a60 、OC(O)R b60 、OC(O)NR c60 R d60 NR c60 R d60 NR c60 C(O)R b60 NR c60 C(O)OR a60 NR c60 C(O)NR c60 R d60 NR c60 S(O)2R b60 、S(O)2R b60 and S(O)2NR c60 Rd60 ;

[0502] Each R 70 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a70 SR a70 、C(O)R b70 、C(O)NR c70 R d70 、C(O)OR a70 、OC(O)R b70 、OC(O)NR c70 R d70 NR c70 R d70 NR c70 C(O)R b70 NR c70 C(O)OR a70 NR c70 C(O)NR c70 R d70 NR c70 S(O)2R b70 、S(O)2R b70 and S(O)2NR c70 R d70 ;

[0503] Each R a1 、R b1 、R c1 and R d1 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R g Substituents substituted;

[0504] Each R a2 、R b2 、R c2 and R d2 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R 22 Substituents substituted;

[0505] Each R a3 、R b3 、R c3 and R d3 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0506] or any R attached to the same N atom c3 and R d3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 30 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0507] Each R f3 and R j3 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0508] or any R attached to the same N atom c3 and R j3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 30a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0509] Each R a5 、R b5 、R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted;

[0510] or any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 50 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0511] Each R a6 、R b6 、R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 60 Substituents substituted;

[0512] or any R attached to the same N atom c6 and R d6 Together with the nitrogen atom to which it is attached, it forms a 4-, 5- or 6-membered heterocycloalkyl group optionally substituted by 1, 2 or 3 groups independently selected from R 60 Substituents substituted;

[0513] Each R a7、R b7 、R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 70 Substituents substituted;

[0514] or any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 70 A 4-membered, 5-membered or 6-membered heterocycloalkyl group substituted with a substituent;

[0515] Each R a10 、R b10 、R c10 and R d10 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 11 Substituents substituted;

[0516] or any R attached to the same N atom c10 and R d10 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 11 A 4-membered, 5-membered or 6-membered heterocycloalkyl group substituted with a substituent;

[0517] Each R a11 、R b11 、R c11 and R d11 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6alkyl halide;

[0518] Each R a20 、R b20 、R c20 and R d20 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 21 Substituents substituted;

[0519] or any R attached to the same N atom c20 and R d20 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 21 A 4-membered, 5-membered or 6-membered heterocycloalkyl group substituted with a substituent;

[0520] Each R a21 、R b21 、R c21 and R d21 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 alkyl halide;

[0521] Each R a22 、R b22 、R c22 and R d22 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 alkyl halide;

[0522] Each R a30 、R b30 、R c30 and R d30 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 Substituents substituted;

[0523] or any R attached to the same N atom c30 and R d30 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 31 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0524] Each R a31 、R b31 、R c31 and R d31 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 32 Substituents substituted;

[0525] or any R attached to the same N atom c31 and R d31 Together with the nitrogen atom to which it is attached, it forms a 4-, 5- or 6-membered heterocycloalkyl group optionally substituted by 1, 2 or 3 groups independently selected from R 32 Substituents substituted;

[0526] Each R a32 、R b32 、R c32 and R d32 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 alkyl halide;

[0527] Each R a50 、R b50 、R c50 and R d50 Independently selected from H, C 1-6 Alkyl, C 2-6Alkenyl, C 2-6 Alkynyl and C 1-6 alkyl halide;

[0528] Each R a60 、R b60 、R c60 and R d60 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 alkyl halide;

[0529] Each R a70 、R b70 、R c70 and R d70 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 haloalkyl; and

[0530] Each R g Independently selected from D, OH, CN, halo, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 1-3 Alkoxy-C 1-3 Alkyl, C 1-3 HO-C 1-3 Alkyl, cyano-C 1-3 Alkyl, H2N-C 1-3 Alkyl, amino, C 1-6 Alkylamino, di(C 1-6 Alkyl)amino, C 1-6 Alkylsulfonyl, C 1-6 Alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, carboxyl, C 1-6 Alkylcarbonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylcarbonylamino, C 1-6 Alkoxycarbonylamino, C 1-6 Alkylcarbonyloxy, C 1-6 Alkylaminocarbonyloxy, di(C 1-6 alkyl)aminocarbonyloxy, C 1-6 Alkylaminocarbonylamino and di(C 1-6 alkyl)aminocarbonylamino.

[0531] In one embodiment of Formula I or a pharmaceutically acceptable salt thereof,

[0532] Indicates a single bond or a double bond;

[0533] X is N or CR 7 ;

[0534] Y is N or C;

[0535] R 1 Selected from H, D, C 1-6 Alkyl, C 1-6 haloalkyl, halo, and CN;

[0536] R 2 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a2 and NR c2 R d2 wherein said C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R 22 Substituents substituted;

[0537] Cy 1 Selected from C 6-10 wherein each of the 6-10 membered heteroaryl groups has at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the ring-forming carbon atoms of the 6-10 membered heteroaryl groups are optionally substituted with oxo groups to form carbonyl groups; and wherein the C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 independently selected R 10 Substituents substituted;

[0538] R 3 Selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR f3 and NR c3 R j3 wherein said C 1-6 Alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0539] R 5 Selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 6-10 aryl, 5-10 membered heteroaryl and D; wherein said C 1-6 Alkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted;

[0540] When R 4 R 5 C YR 6 is a double bond and Y is N, then R 4 and R 6 does not exist;

[0541] When R 4 R 5 C YR 6 is a double bond and Y is C, then R 4 does not exist; and

[0542] R 6 Selected from H, D, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 60 Substituents substituted;

[0543] R 7 Selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, halo, D, and CN;

[0544] Cy 2 is a 4-14 membered heterocycloalkyl group; wherein the 4-14 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; and wherein the 4-14 membered heterocycloalkyl group is optionally replaced by 1, 2, 3 or 4 ring-forming heteroatoms independently selected from R 20 Substituents substituted;

[0545] Each R 10 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a10 and NR c10 R d10 ;

[0546] Each R 20 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a20 、C(O)R b20 、C(O)NR c20 R d20 、C(O)OR a20 and NR c20 R d20 wherein said C 1-6 The alkyl group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 21 Substituents substituted;

[0547] Each R 21 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a21 and NR c21 R d21 ;

[0548] Each R 22 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a22 and NR c22 R d22 ;

[0549] Each R 30 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, halo, D, CN, OR a30 and NR c30 R d30 wherein said C 1-6 Alkyl, 4-10 membered heterocycloalkyl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 Substituents substituted;

[0550] Each R 31 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a31 and NR c31 R d31 ;

[0551] Each R 50 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, ORa50 and NR c50 R d50 ;

[0552] Each R 60 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a60 、C(O)R b60 、C(O)NR c60 R d60 、C(O)OR a60 and NR c60 R d60 ;

[0553] Each R a2 、R c2 and R d2 Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0554] Each R c3 Independently selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, 4-10 membered heterocycloalkyl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, 4-10 membered heterocycloalkyl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0555] Each R f3 and R j3 Independently selected from C 1-6 Alkyl, C 1-6 haloalkyl, 4-10 membered heterocycloalkyl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, 4-10 membered heterocycloalkyl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted;

[0556] or any R attached to the same N atom c3 and R j3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1, 2, 3 or 4 independently selected R 30 a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl substituted with a substituent;

[0557] Each R a10 、R b10 、R c10 and R d10 Independently selected from H, C 1-6 Alkyl and C 1-6alkyl halide;

[0558] Each R a20 、R b20 、R c20 and R d20 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R 21 Substituents substituted;

[0559] Each R a21 、R b21 、R c21 and R d21 Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0560] Each R a30 、R b30 、R c30 and R d30 Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0561] Each R a31 、R b31 、R c31 and R d31 Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0562] Each R a50 、R b50 、R c50 and R d50 Independently selected from H, C 1-6 Alkyl and C 1-6 haloalkyl; and

[0563] Each R a60 、R b60 、R c60 and R d60 Independently selected from H, C 1-6 Alkyl and C 1-6 Halogenated alkyl.

[0564] In another embodiment of Formula I or a pharmaceutically acceptable salt thereof,

[0565] Indicates a single bond or a double bond;

[0566] X is CR 7 ;

[0567] Y is N or C;

[0568] R 1 It is H;

[0569] R 2 Selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, halo, D and CN; wherein said C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 22 Substituents substituted;

[0570] Cy 1 Selected from C 6-10 aryl and 6-10 membered heteroaryl; wherein each of the 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 10 Substituents substituted;

[0571] R 3 Selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, 4-6 membered heterocycloalkyl, OR f3 and NR c3 R j3 wherein said C 1-6 Alkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1 or 2 independently selected R 30 Substituents substituted;

[0572] R 5 Selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, phenyl, 5-6 membered heteroaryl and D; wherein said C 1-6 Alkyl, phenyl and 5-6 membered heteroaryl are each optionally substituted by 1 or 2 groups independently selected from R 50 Substituents substituted;

[0573] When R 4 R 5 C YR 6 is a double bond and Y is N, then R 4 and R 6 does not exist;

[0574] When R 4 R 5 C YR 6 is a double bond and Y is C, then R 4 does not exist; and

[0575] R 6 Selected from H, D, C 1-6 Alkyl and C 1-6 Haloalkyl; wherein the C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 60 Substituents substituted;

[0576] R 7 Selected from halogenated;

[0577] Cy 2 is a 4-8 membered heterocycloalkyl group; wherein the 4-8 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the 4-8 membered heterocycloalkyl group is optionally replaced by 1 or 2 ring-forming heteroatoms independently selected from R 20 Substituents substituted;

[0578] Each R 10 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a10 and NR c10 R d10 ;

[0579] Each R 20 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, Halo, D, CN, and C(O)R b20 wherein said C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 21 Substituents substituted;

[0580] Each R 21 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a21 and NR c21 R d21 ;

[0581] Each R 22 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a22 and NR c22 R d22 ;

[0582] Each R 30 Independently selected from C1-6 Alkyl, C 1-6 Haloalkyl, 4-6 membered heterocycloalkyl, 5-6 membered heteroaryl, halo, D, CN, OR a30 and NR c30 R d30 wherein said C 1-6 Alkyl, 4-6 membered heterocycloalkyl and 5-6 membered heteroaryl are each optionally substituted by 1 or 2 groups independently selected from R 31 Substituents substituted;

[0583] Each R 31 Independently selected from C 1-6 Alkyl, C 1-6 haloalkyl, halo, D, and CN;

[0584] Each R 50 Independently selected from C 1-6 Alkyl, C 1-6 haloalkyl, halo, D, and CN;

[0585] Each R 60 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a60 、C(O)R b60 、C(O)NR c60 R d60 、C(O)OR a60 and NR c60 R d60 ;

[0586] Each R c3 Independently selected from H, C 1-6 Alkyl and C 1-6 Haloalkyl; wherein the C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 30 Substituents substituted;

[0587] Each R f3 and R j3 Independently selected from C 1-6 Alkyl and C 1-6 Haloalkyl; wherein the C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 30 Substituents substituted;

[0588] Each R a10 、R b10 、R c10 and R d10 Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0589] Each R a20 、R b20 、R c20 and R d20 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl; wherein the C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1 or 2 independently selected R 21 Substituents substituted;

[0590] Each R a21 、R b21 、R c21 and R d21 Independently selected from H, C 1-6 Alkyl and C 1-6 alkyl halide;

[0591] Each R a30 、R b30 、R c30 and R d30 Independently selected from H, C 1-6 Alkyl and C 1-6 haloalkyl; and

[0592] Each R a60 、R b60 、R c60 and R d60 Independently selected from H, C 1-6 Alkyl and C 1-6 Halogenated alkyl.

[0593] In another embodiment, the compound of formula I is a compound of formula II:

[0594]

[0595] or a pharmaceutically acceptable salt thereof.

[0596] In yet another embodiment,

[0597] R 1 Selected from H, D, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, CN, OR a1 and NR c1 R d1 ;

[0598] R 2Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a2 and NR c2 R d2 ;

[0599] Cy 1 Selected from C 6-10 aryl and 6-10 membered heteroaryl; wherein each of the 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 6-10 membered heteroaryl are optionally substituted with oxo to form a carbonyl; and wherein the C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 10 Substituents substituted;

[0600] R 3 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR f3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 NR c3 R j3 NR c3 C(O)R b3 NR c3 C(O)OR a3 and S(O)2R b3 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 30 Substituents substituted;

[0601] R 5 Selected from H, C 1-6Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 C(O)R b5 NR c5 C(O)OR a5 and S(O)2R b5 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 50 Substituents substituted;

[0602] R 7 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a7 and NR c7 R d7 ;

[0603] Cy 2 is a 4-10 membered heterocycloalkyl group; wherein the 4-10 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 4-10 membered heterocycloalkyl group are optionally substituted with oxo groups to form a carbonyl group; and wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1 or 2 ring-forming heteroatoms independently selected from R 20 Substituents substituted;

[0604] Each R 10 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6Haloalkyl, halo, D, CN, OR a10 、C(O)R b10 、C(O)NR c10 R d10 、C(O)OR a10 、OC(O)R b10 、OC(O)NR c10 R d10 NR c10 R d10 NR c10 C(O)R b10 NR c10 C(O)OR a10 and S(O)2R b10 ;

[0605] Each R 20 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a20 、C(O)R b20 、C(O)NR c20 R d20 、C(O)OR a20 、OC(O)R b20 、OC(O)NR c20 R d20 NR c20 R d20 NR c20 C(O)R b20 NR c20 C(O)OR a20 and S(O)2R b20 ;

[0606] Each R 30 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 、C(O)R b30 、C(O)NR c30 R d30 、C(O)OR a30 、OC(O)R b30 、OC(O)NR c30 R d30 NR c30 Rd30 NR c30 C(O)R b30 NR c30 C(O)OR a30 and S(O)2R b30 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 31 Substituents substituted;

[0607] Each R 31 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a31 and NR c31 R d31 ;

[0608] Each R 50 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a50 and NR c50 R d50 ;

[0609] Each R a1 、R c1 and R d1 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 alkyl halide;

[0610] Each R a2 、R c2 and R d2 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 alkyl halide;

[0611] Each R a3 、R b3 、R c3 and R d3 Independently selected from H, C 1-6 Alkyl, C2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 30 Substituents substituted;

[0612] or any R attached to the same N atom c3 and R d3 Together with the N atom to which it is attached, it forms a group optionally substituted by 1 or 2 independently selected R 30 A 4-membered, 5-membered or 6-membered heterocycloalkyl group substituted with a substituent;

[0613] Each R a5 、R b5 、R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 50 Substituents substituted;

[0614] or any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a group optionally substituted by 1 or 2 independently selected R 50 A 4-membered, 5-membered or 6-membered heterocycloalkyl group substituted with a substituent;

[0615] Each R a7 、R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C1-6 alkyl halide;

[0616] Each R a10 、R b10 、R c10 and R d10 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 alkyl halide;

[0617] Each R a20 、R b20 、R c20 and R d20 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 alkyl halide;

[0618] Each R a30 、R b30 、R c30 and R d30 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 31 Substituents substituted;

[0619] or any R attached to the same N atom c30 and R d30 Together with the N atom to which it is attached, it forms a group optionally substituted by 1 or 2 independently selected R 31 A 4-membered, 5-membered or 6-membered heterocycloalkyl group substituted with a substituent;

[0620] Each R a31 、R c31 and R d31 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 haloalkyl; and

[0621] Each R a50 、R c50 and R d50 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Halogenated alkyl.

[0622] In yet another embodiment,

[0623] R 1 Selected from H, D and C 1-3 alkyl;

[0624] R 2 Selected from H, C 1-3 Alkyl, C 1-3 haloalkyl, halo, D, and CN;

[0625] Cy 1 It is C 6-10 Aryl; and wherein said C 6-10 Aryl is optionally substituted by 1 or 2 independently selected from R 10 Substituents substituted;

[0626] R 3 Selected from H, C 1-3 alkyl, 4-6 membered heterocycloalkyl and D; wherein said C 1-3 Alkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1 or 2 independently selected R 30 Substituents substituted;

[0627] R 5 Selected from H, C 1-3 Alkyl and D;

[0628] R 7 Selected from H, C 1-3 Alkyl, C 1-3 haloalkyl, halo, D, and CN;

[0629] Cy 2 is a 4-6 membered heterocycloalkyl group; wherein the 4-6 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the 4-6 membered heterocycloalkyl group is optionally replaced by 1 or 2 ring-forming heteroatoms independently selected from R 20 Substituents substituted;

[0630] Each R 10 Independently selected from C 1-3 Alkyl, C 1-3 Haloalkyl, halo, D, CN, and OR a10 ;

[0631] Each R20 Independently selected from C 1-3 Alkyl, D, and C(O)R b20 ;

[0632] Each R 30 Independently selected from C 1-3 Alkyl, C 1-3 Haloalkyl, halo, D, CN, OR a30 and NR c30 R d30 ;

[0633] Each R a10 Independently selected from H and C 1-3 alkyl;

[0634] Each R b20 Independently selected from H, C 1-3 Alkyl and C 2-3 alkenyl; and

[0635] Each R a30 、R c30 and R d30 Independently selected from H, C 1-3 Alkyl and C 1-3 Halogenated alkyl.

[0636] In one embodiment,

[0637] X is CR 7 ;

[0638] R 1 Selected from H;

[0639] R 2 Selected from H, C 1-3 Haloalkyl and halo;

[0640] Cy 1 It is C 10 Aryl; and wherein said C 10 Aryl is optionally substituted by 1 or 2 independently selected from R 10 Substituents substituted;

[0641] R 3 is selected from H and 4-6 membered heterocycloalkyl; wherein said 4-6 membered heterocycloalkyl is optionally substituted by 1 or 2 independently selected from R 30 Substituents substituted;

[0642] R 5 It is H;

[0643] R 4 R 5 C YR 6 is a double bond, Y is N, and R4 and R 6 does not exist;

[0644] R 7 Selected from H or halo;

[0645] Cy 2 is a 4-6 membered heterocycloalkyl group; wherein the 4-6 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the 4-6 membered heterocycloalkyl group is optionally replaced by 1 or 2 ring-forming heteroatoms independently selected from R 20 Substituents substituted;

[0646] Each R 10 Independently selected from OR a10 ;

[0647] Each R 20 independently selected from C(O)R b20 ;

[0648] Each R 30 Independently selected from NR c30 R d30 ;

[0649] Each R a10 Independently selected from H and C 1-3 alkyl;

[0650] Each R b20 It is C 1-3 Alkyl or C 2-4 alkenyl; and

[0651] Each R c30 and R d30 Independently selected from C 1-3 alkyl.

[0652] In another embodiment of Formula I or a pharmaceutically acceptable salt thereof,

[0653] Indicates a single bond or a double bond;

[0654] X is CH or C-halogen;

[0655] Y is N or C;

[0656] R 1 It is H;

[0657] R 2 Selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, halo and CN; wherein said C 1-6 The alkyl group is optionally substituted with 1 or 2 substituents independently selected from the group consisting of D, CN, OH, O(C 1-6alkyl), NH2, NH(C 1-6 alkyl) and (C 1-6 Alkyl)2;

[0658] Cy 1 Selected from C 6-10 aryl and 6-10 membered heteroaryl; wherein each of the 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of OH, halo, C 1-6 Alkyl and C 1-6 alkyl halide;

[0659] R 3 Selected from H, C 1-6 Alkyl and 4-6 membered heterocycloalkyl and O(C 1-6 Alkyl); wherein said C 1-6 Alkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1 or 2 independently selected R 30 Substituents substituted;

[0660] R 5 selected from H, phenyl and 5-6 membered heteroaryl; wherein the phenyl and 5-6 membered heteroaryl are each optionally substituted by 1 or 2 independently selected from C 1-6 Substitution of alkyl groups;

[0661] When R 4 R 5 C YR 6 is a double bond and Y is N, then R 4 and R 6 does not exist;

[0662] When R 4 R 5 C YR 6 is a double bond and Y is C, then R 4 does not exist; and

[0663] R 6 Selected from H, C 1-6 alkyl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected C 1-6 Alkyl, C(O)N(C 1-6 alkyl)2 and C(O)OC 1-6 Substitution of alkyl groups;

[0664] Cy 2is a 4-8 membered heterocycloalkyl group; wherein the 4-8 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the 4-8 membered heterocycloalkyl group is optionally replaced by 1 or 2 ring-forming heteroatoms independently selected from C 1-6 Alkyl-CN and C(O)R b20 Substituents substituted;

[0665] Each R 30 Independently selected from C 1-6 Alkyl, 4-6 membered heterocycloalkyl, halo and N(C 1-6 wherein the 4-6 membered heterocycloalkyl group is optionally substituted by 1 or 2 independently selected C 1-6 The alkyl group is substituted with a substituent; and

[0666] Each R b20 Independently selected from C 2-6 Alkenyl and C 2-6 Alkynyl; wherein the C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted with 1 or 2 substituents independently selected from the group consisting of: C 1-6 Alkyl, C 1-6 Alkyl O(C 1-6 Alkyl), C 1-6 Haloalkyl, halo and C 1-6 Alkyl-N(C 1-6 Alkyl)2.

[0667] In another embodiment, the compound of formula I is a compound of formula III:

[0668]

[0669] or a pharmaceutically acceptable salt thereof.

[0670] In yet another embodiment, wherein the compound of Formula I is a compound of Formula IV:

[0671]

[0672] or a pharmaceutically acceptable salt thereof.

[0673] In yet another embodiment, the compound of Formula I is a compound of Formula V:

[0674]

[0675] or a pharmaceutically acceptable salt thereof.

[0676] In one embodiment, the compound of formula I is a compound of formula VI:

[0677]

[0678] or a pharmaceutically acceptable salt thereof.

[0679] In another embodiment, the compound of formula I is a compound of formula VII:

[0680]

[0681]

[0682] or a pharmaceutically acceptable salt thereof.

[0683] In yet another embodiment, X is CR 7 In yet another embodiment, X is N.

[0684] In one embodiment, R 4 R 5 C YR 6 is a double bond, Y is N, and R 4 and R 6 In another embodiment, R 4 R 5 C YR 6 is a single bond and YR 6 is C=O. In one embodiment, R 4 R 5 C YR 6 is a double bond, Y is C, and R 4 Does not exist.

[0685] In yet another embodiment, R 1 Selected from H, D, C 1-6 Alkyl, C 1-6 Haloalkyl, halo, OR a1 and NR c1 R d1 In yet another embodiment, R 1 Selected from H, D, C 1-6 Alkyl, C 1-6 In yet another embodiment, R 1 Selected from H, D and C 1-3 In yet another embodiment, R 1 It’s H.

[0686] In one embodiment, R 2 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6Haloalkyl, halo, D, CN, OR a2 and NR c2 R d2 wherein said C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R 22 In another embodiment, R 2 Selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, halo, D and CN; wherein said C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 22 In another embodiment, R 2 Selected from C 1-6 Alkyl and halo; wherein the C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 22 substituted by a substituent.

[0687] In one embodiment, R 2 Selected from H, D, C 1-6 Alkyl, C 1-6 Haloalkyl, halo, OR a1 and NR c1 R d1 In another embodiment, R 2 Selected from H, D, C 1-6 In yet another embodiment, R 2 Selected from H, D, C 1-6 Alkyl, C 1-6 In one embodiment, R 2 Selected from H, D, C 1-2 Alkyl, C 1-2 In yet another embodiment, R 2 In another embodiment, R 2 It's chlorine.

[0688] In one embodiment, each R 22 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a22 and NR c22 R d22 In one embodiment, each R 22 Independently selected from C 1-6 Alkyl, C 1-6 In one embodiment, R22 It is CN.

[0689] In yet another embodiment, Cy 1 Selected from C 6-10 aryl and 6-10 membered heteroaryl; wherein each of the 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 6-10 membered heteroaryl are optionally substituted with oxo to form a carbonyl; and wherein the C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 10 substituted by a substituent.

[0690] In one embodiment, Cy 1 is optionally substituted by 1 or 2 independently selected from R 10 Substituents substituted C 6-10 In another embodiment, Cy 1 is optionally substituted by 1 or 2 independently selected from R 10 Substituents substituted C 6-10 In yet another embodiment, Cy 1 is optionally replaced by R 10 Replace once C 6-10 In yet another embodiment, Cy 1 is optionally replaced by R 10 In yet another embodiment, Cy 1 It is 3-hydroxy-naphthalen-1-yl.

[0691] In one embodiment, Cy 1 Selected from C 6-10 aryl and 6-10 membered heteroaryl; wherein each of the 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 10 In yet another embodiment, Cy 1 Selected from optionally 1 or 2 independently selected from R 10 The substituents include naphthyl and 1H-indazolyl.

[0692] In yet another embodiment, Cy 1 is a 5-10 membered heteroaryl group, provided that Cy 1 is not 3,5-dimethylisoxazol-4-yl. In another embodiment, Cy 1 Not 3,5-dimethylisoxazol-4-yl.

[0693] In yet another embodiment, each R 10 Independently selected from C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, halo, D, CN, OR a10 and NR c10 R d10 wherein said C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1 or 2 independently selected R 11 substituted by a substituent.

[0694] In yet another embodiment, each R 10 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a10 and NR c10 R d10 In another embodiment, each R 10 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo and OR a10 In one embodiment, each R 10 Independently selected from C 1-6 Alkyl, halo and OR a10 In another embodiment, each R 10 In another embodiment, each R 10 Independently selected from methyl, fluoro and hydroxy.

[0695] In one embodiment, each R 10 Independently selected from C 1-3 Alkyl, C 1-3 Haloalkyl, halo, D, CN, and OR a10 In one embodiment, each R 10 Independently selected from halo and OR a10 In one embodiment, each R 10 In one embodiment, R 10 It's OH.

[0696] In yet another embodiment, each R 11 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a11 and NR c11R d11 .

[0697] In yet another embodiment, R 3 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, OR f3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 and NR c3 R j3 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 30 substituted by a substituent.

[0698] In one embodiment, R 3 Selected from H, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo and OR f3 wherein said C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 30 In one embodiment, R 3 Selected from H, 4-10 membered heterocycloalkyl, C 6-10 Aryl and OR f3 wherein the 4-10 membered heterocycloalkyl and C 6-10 Each aryl group is optionally substituted by 1 or 2 independently selected R 30 substituted by a substituent.

[0699] In another embodiment, R 3 is H or 4-7 membered heterocycloalkyl; wherein said 4-7 membered heterocycloalkyl is optionally substituted by 1 or 2 independently selected R 30 In yet another embodiment, R 3is a 4-7 membered heterocycloalkyl group; wherein the 4-7 membered heterocycloalkyl group is optionally substituted by 1 or 2 independently selected R 30 In yet another embodiment, R 3 is a 4-membered heterocycloalkyl group, which is optionally substituted by 1 or 2 members independently selected from R 30 substituted by a substituent.

[0700] In another embodiment, R 3 Selected from H, 4-6 membered heterocycloalkyl and OR f3 wherein the 4-6 membered heterocycloalkyl group is optionally substituted by 1 or 2 independently selected R 30 In one embodiment, R 3 is optionally replaced by R 30 In another embodiment, R 3 In another embodiment, R 3 In another embodiment, R 3 is 3-(dimethylamino)azetidin-1-yl. In yet another embodiment, R 3 It’s H.

[0701] In one embodiment, each R 30 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, halo, D, CN, OR a30 and NR c30 R d30 wherein said C 1-6 Alkyl, 4-10 membered heterocycloalkyl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 31 In one embodiment, each R 30 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, 4-6 membered heterocycloalkyl, 5-6 membered heteroaryl, halo, D, CN, OR a30 and NR c30 R d30 wherein said C 1-6 Alkyl, 4-6 membered heterocycloalkyl and 5-6 membered heteroaryl are each optionally substituted by 1 or 2 groups independently selected from R 31 substituted by a substituent.

[0702] In another embodiment, R 30 It is NRc30 R d30 In yet another embodiment, R 30 It is NR c30 R d30 ; and R c30 and R d30 Each is independently C 1-3 alkyl.

[0703] In another embodiment, each R 30 Independently selected from 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, halo, OR a30 and NR c30 R d30 wherein the 4-10 membered heterocycloalkyl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 31 substituted by a substituent.

[0704] In yet another embodiment, each R 31 Independently selected from C 1-6 Alkyl, halo, D, CN, OR a31 and NR c31 R d31 In one embodiment, each R 31 Independently selected from C 1-6 Alkyl, C 1-6 In one embodiment, each R 31 Independently C 1-6 In another embodiment, each R 31 is independently methyl.

[0705] In another embodiment, each R a3 、R b3 、R c3 and R d3 Independently selected from H, C 1-6 Alkyl and C 1-6 Haloalkyl; wherein the C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 30 In another embodiment, each R f3 and R j3 Independently selected from C 1-6 Alkyl and C 1-6 Haloalkyl; wherein the C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 30 substituted by a substituent.

[0706] In yet another embodiment, each R a3 Independently C 1-6 Alkyl; wherein the C1-6 The alkyl group is optionally substituted by 1 independently selected from R 30 In yet another embodiment, each R a3 is independently methyl; wherein the methyl group is replaced by 1 independently selected from R 30 substituted by a substituent.

[0707] In another embodiment, each R f3 Independently C 1-6 Alkyl; wherein the C 1-6 The alkyl group is optionally substituted by 1 independently selected from R 30 In yet another embodiment, each R f3 is independently methyl; wherein the methyl group is replaced by 1 independently selected from R 30 substituted by a substituent.

[0708] In one embodiment, R 4 Selected from H, D, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, CN, OR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 NR c4 R d4 NR c4 C(O)R b4 NR c4 C(O)OR a4 NR c4 C(O)NR c4 R d4 NR c4 S(O)2R b4 、S(O)2R b4 and S(O)2NR c4 R d4 In another embodiment, R 4 Selected from H, D, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, CN, OR a4 、C(O)R b4、C(O)NR c4 R d4 、C(O)OR a4 and OC(O)R b4 In yet another embodiment, R 4 Selected from H, D, C 1-6 Alkyl, C 1-6 In yet another embodiment, R 4 It’s H.

[0709] In one embodiment, R 5 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, halo, D, CN, OR a5 SR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)OR a5 、OC(O)R b5 NR c5 R d5 and NR c5 C(O)R b5 In another embodiment, R 5 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 In yet another embodiment, R 5 Selected from H, C 1-6 Alkyl, C 1-6 In yet another embodiment, R 5 Is H or C 1-3 In another embodiment, R 5 It’s H.

[0710] In one embodiment, R 5 Selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 6-10aryl, 5-10 membered heteroaryl and D; wherein said C 1-6 Alkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 In another embodiment, R 5 Selected from H, C 1-6 Alkyl, C 1-6 haloalkyl, phenyl, 5-6 membered heteroaryl and D; wherein said C 1-6 Alkyl, phenyl and 5-6 membered heteroaryl are each optionally substituted by 1 or 2 groups independently selected from R 50 substituted by a substituent.

[0711] In one embodiment, R 5 Selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a5 、C(O)NR c5 R d5 and NR c5 R d5 wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 50 In another embodiment, R 5 Selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, CN, OR a5 and C(O)NR c5 R d5 wherein said C 1-6 Alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 50 substituted by a substituent.

[0712] In another embodiment, each R 50 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a50 and NR c50 R d50 In one embodiment, each R50 Independently selected from C 1-6 Alkyl, C 1-6 In one embodiment, each R 50 It is C 1-6 alkyl.

[0713] In one embodiment, each R 50 Independently selected from C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a50 and NR c50 R d50 In another embodiment, each R 50 Independently selected from C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, CN, OR a50 and NR c50 R d50 .

[0714] In one embodiment, each R 51 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a51 and NR c51 R d51 In another embodiment, each R 51 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D and CN.

[0715] In one embodiment, R 6 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, NO2, OR a6 SR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 Rd6 NR c6 R d6 NR c6 C(O)R b6 NR c6 C(O)OR a6 NR c6 C(O)NR c6 R d6 NR c6 S(O)R b6 NR c6 S(O)2R b6 NR c6 S(O)2NR c6 R d6 、S(O)R b6 、S(O)NR c6 R d6 、S(O)2R b6 and S(O)2NR c6 R d6 In another embodiment, R 6 Selected from H, D, C 1-6 Alkyl, C 1-6 Halogenated alkyl, OR a6 and NR c6 R d6 In another embodiment, R 6 Selected from H, D, C 1-6 Alkyl and C 1-6 Halogenated alkyl.

[0716] In one embodiment, R 6 Selected from H, D, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl; wherein the C 1-6 Alkyl, C 3-6 Cycloalkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 60 In another embodiment, R 6 Selected from H, D, C 1-6 Alkyl and C 1-6 Haloalkyl; wherein the C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 60 substituted by a substituent.

[0717] In yet another embodiment, R 6 Selected from H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a6 and NR c6 R d6 wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 60 substituted by a substituent.

[0718] In one embodiment, each R 60 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a60 、C(O)R b60 、C(O)NR c60 R d60 、C(O)OR a60 and NR c60 R d60 In another embodiment, each R 60 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, CN, C(O)NR c60 R d60 and C(O)OR a60 .

[0719] In one embodiment, each R 60 Independently selected from C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a60 、C(O)NR c60 R d60 、C(O)OR a60 and NR c60 R d60 In another embodiment, each R 60 Independently selected from C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 6-10 Aryl, halo, D, CN, OR a60 、C(O)NR c60 R d60 、C(O)OR a60 and NR c60 R d60 .

[0720] In yet another embodiment, R 7 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, NO2, OR a7 SR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 NR c7 S(O)2R b7 NR c7 S(O)2NR c7 R d7 、S(O)2R b7 and S(O)2NR c7 R d7 In yet another embodiment, R 7 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl and halo. In one embodiment, R 7 Selected from H, D, C 1-3 Alkyl, C 1-3 In yet another embodiment, R 7 In yet another embodiment, R 7 It's fluorine.

[0721] In one embodiment, Cy 2is a 4-6 membered heterocycloalkyl group; wherein the 4-6 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the 4-6 membered heterocycloalkyl group is optionally replaced by 1 or 2 ring-forming heteroatoms independently selected from R 20 Substituents substituted;

[0722] In another embodiment, Cy 2 Selected from C 3-6 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 wherein the 4-10 membered heterocycloalkyl and the 5-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; wherein the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl; and wherein the C 3-6 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 20 substituted by a substituent.

[0723] In another embodiment, Cy 2 is a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the 4-10 membered heterocycloalkyl group is optionally replaced by 1 or 2 ring-forming heteroatoms independently selected from R 20 substituted by a substituent.

[0724] In yet another embodiment, Cy 2 is a 4-6 membered heterocycloalkyl group; wherein the 4-6 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the 4-6 membered heterocycloalkyl group is optionally replaced by R 20 Replace once;

[0725] In yet another embodiment, Cy 2 is selected from the group consisting of 4-(piperidin-1-yl)prop-2-en-1-one, 3-(piperidin-1-yl)prop-2-en-1-one, 3-azetidin-1-yl)prop-2-en-1-one and 3-pyrrolidin-1-yl)prop-2-en-1-one. In yet another embodiment, Cy 2 is 4-(piperidin-1-yl)prop-2-en-1-one. In one embodiment, Cy 2 is 3-(piperidin-1-yl)prop-2-en-1-one. In another embodiment, Cy 2In yet another embodiment, Cy 2 It is 3-(pyrrolidin-1-yl)prop-2-en-1-one.

[0726] In one embodiment, Cy 2 is optionally replaced by R 20 One or two substituted 4-6 membered heterocycloalkyl. In yet another embodiment, R 20 It is C(O)R b20 .

[0727] In one embodiment, Cy 2 Selected from

[0728]

[0729] In another embodiment, Cy 2 It's Cy 2 -a. In yet another embodiment, Cy 2 It's Cy 2 -b. In yet another embodiment, Cy 2 It's Cy 2 -c. In one embodiment, Cy 2 It's Cy 2 -d.

[0730] In yet another embodiment, Cy 2 Selected from

[0731]

[0732] Where n is 0, 1, or 2.

[0733] In one embodiment, Cy 2 It's Cy 2 -a1. In another embodiment, Cy 2 It's Cy 2 -b1. In yet another embodiment, Cy 2 It's Cy 2 -c1. In yet another embodiment, Cy 2 It's Cy 2 -d1. In one embodiment, Cy 2 It's Cy 2 -e.

[0734] In one embodiment, n is 0. In another embodiment, n is 1. In yet another embodiment, n is 2.

[0735] In one embodiment, each R 20 Independently selected from C1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a20 、C(O)R b20 、C(O)NR c20 R d20 、C(O)OR a20 、OC(O)R b20 、OC(O)NR c20 R d20 NR c20 R d20 NR c20 C(O)R b20 NR c20 C(O)OR a20 NR c20 C(O)NR c20 R d20 NR c20 S(O)2R b20 NR c20 S(O)2NR c20 R d20 、S(O)2R b20 and S(O)2NR c20 R d20 .

[0736] In yet another embodiment, each R 20 independently selected from C(O)R b20 、C(O)NR c20 R d20 and C(O)OR a20 In yet another embodiment, each R 20 It is C(O)R b20 .

[0737] In one embodiment, each R 20 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a20 、C(O)R b20 、C(O)NR c20 R d20 、C(O)OR a20 and NR c20 R d20 wherein said C 1-6 The alkyl group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R21 substituted by a substituent.

[0738] In one embodiment, each R 20 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, Halo, D, CN, and C(O)R b20 wherein said C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 21 In one embodiment, each R 20 Independently selected from C 1-6 Alkyl, CN, and C(O)R b20 wherein said C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 21 substituted by a substituent.

[0739] In another embodiment, each R 21 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, OR a21 and NR c21 R d21 In another embodiment, each R 21 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, and OR a21 In another embodiment, R 21 It is CN.

[0740] In another embodiment, each R g Independently selected from D, OH, CN, halo, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Halogenated alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 1-3 Alkoxy-C 1-3 Alkyl, C 1-3 Alkoxy-C 1-3 Alkoxy, HO-C 1-3 Alkoxy, HO-C 1-3 Alkyl, cyano-C 1-3 Alkyl, H2N-C 1-3 Alkyl, amino, C 1-6 Alkylamino, di(C 1-6 Alkyl)amino, C 1-6 Alkylthio, C 1-6Alkylsulfonyl, carbamoyl, C 1-6 Alkylcarbamoyl and di(C 1-6 alkyl)carbamoyl.

[0741] In one embodiment of Formula Ia or a pharmaceutically acceptable salt thereof,

[0742] Y is N or C;

[0743] R 1 It is H;

[0744] R 2 Selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl and halo, wherein alkyl is optionally substituted once with CN;

[0745] Cy 1 Selected from C 6-10 aryl and 6-10 membered heteroaryl; wherein the 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the C 6-10 Aryl and 6-10 membered heteroaryl are each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of OH, halo, C 1-6 Alkyl, C 1-6 Haloalkyl and CN;

[0746] R 3 Selected from H, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, halo and OC 1-6 Alkyl; wherein the OC 1-6 Alkyl, C 3-10 The cycloalkyl and 4-10 membered heterocycloalkyl groups are each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: N(C 1-6 Alkyl)2, C 1-6 Alkyl and optionally C 1-6 Alkyl-substituted 4-6 membered heterocycloalkyl;

[0747] R 5 Selected from H, C 1-6 Alkyl, C 6-10 Aryl, 5-6 membered heteroaryl, C 1-6 Haloalkyl, halo, C(O)NH(C 1-6 alkyl) and 4-6 membered heterocycloalkyl, wherein heteroaryl, heterocycloalkyl and alkyl are optionally substituted by 1 or 2 substituents selected from the group consisting of: C 1-6 Alkyl, OH, C 6-10 Aryl and N(C 1-6 Alkyl)2;

[0748] When Y is N, then R6 does not exist;

[0749] R 6 Selected from H, C 1-6 Alkyl, 5-6 membered heteroaryl and C 1-6 Haloalkyl, wherein alkyl and heteroaryl are optionally substituted with 1 or 2 substituents selected from the group consisting of: C 1-6 Alkyl, C(O)OC 1-6 Alkyl, C(O)N(C 1-6 Alkyl)2, C 6-10 Aryl and C(O)(4-6 membered heterocycloalkyl);

[0750] R 7 is selected from H and halo; and

[0751] Cy 2 wherein the 4-6 membered heterocycloalkyl group has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; and wherein the 4-6 membered heterocycloalkyl group is optionally replaced by 1, 2 or 3 ring-forming heteroatoms independently selected from C(O)C 2-6 Alkenyl, C(O)C 2-6 Alkynyl, C 1-6 Alkyl is substituted with a substituent, wherein the alkenyl and alkyl groups are optionally selected from CN, N(C 1-6 Alkyl)2, OC 1-6 Alkyl and halo substituents are substituted once or twice.

[0752] In one embodiment, the compound of formula I is

[0753] 1-(4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)-piperidin-1-yl)prop-2-en-1-one; or

[0754] 1-(4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one;

[0755] or a pharmaceutically acceptable salt thereof.

[0756] In another embodiment, the compound of formula I is selected from

[0757] 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0758] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile;

[0759] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile;

[0760] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile;

[0761] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile;

[0762] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile;

[0763] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile;

[0764] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile;

[0765] 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0766] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile;

[0767] 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0768] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile;

[0769] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile;

[0770] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile;

[0771] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile;

[0772] 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0773] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile;

[0774] 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0775] 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile;

[0776] 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0777] 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-fluoroquinolin-8-yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0778] 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-4-yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0779] 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0780] 2-((2S,4S)-4-(8-chloro-7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile;

[0781] 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0782] 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0783] 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-methyl-2-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0784] 2-((2S,4S)-1-acryloyl-4-(8-chloro-6-fluoro-7-(3-methyl-2-(trifluoromethyl)phenyl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0785] methyl 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-2-yl)propanoate;

[0786] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-2-yl)-N,N-dimethylpropionamide;

[0787] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-2-propyl-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0788] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-(1-methyl-1H-pyrazol-4-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0789] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0790] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-phenyl-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0791] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(pyridin-3-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0792] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-3-(2-methyloxazol-5-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0793] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(2-methylthiazol-5-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; and

[0794] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-3-(1-methyl-1H-pyrazol-4-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0795] or a pharmaceutically acceptable salt thereof.

[0796] In yet another embodiment, the compound of Formula I is selected from the group consisting of:

[0797] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-(1-methyl-1H-pyrazol-3-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0798] 3-(2-Benzyl-1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0799] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0800] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0801] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-3-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0802] 1-(2-Azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-N-(2-hydroxyethyl)-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinoline-3-carboxamide;

[0803] N-Benzyl-1-(2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinoline-3-carboxamide;

[0804] 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-3-(hydroxymethyl)-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0805] 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile;

[0806] 3-(1-((1R,4R,5S)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-4-ethoxy-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-pyrrolo[3,2-c]quinolin-2-yl)-N,N-dimethylpropionamide;

[0807] methyl 3-(1-((1R,4R,5S)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-3-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-methoxy-1H-pyrrolo[3,2-c]quinolin-2-yl)propanoate;

[0808] 3-(2-(3-(azetidin-1-yl)-3-oxopropyl)-1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(7-fluoronaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile;

[0809] 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0810] 8-(1-((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0811] 8-(1-((2S,4S)-1-(but-2-ynyl)-2-(cyanomethyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0812] 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0813] 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0814] 8-(1-((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0815] 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0816] 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0817] 8-(1-((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0818] 8-(1-((2S,4S)-1-(but-2-ynyl)-2-(cyanomethyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0819] 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0820] 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile;

[0821] 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile;

[0822] 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile;

[0823] 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile;

[0824] 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile;

[0825] 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile;

[0826] 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile;

[0827] 2-((2S,4S)-1-(but-2-ynyl)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0828] 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile;

[0829] 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile;

[0830] 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile;

[0831] 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile;

[0832] 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0833] 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile;

[0834] 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile;

[0835] 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile;

[0836] 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0837] 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile;

[0838] 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile;

[0839] 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile;

[0840] 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0841] 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile;

[0842] 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile;

[0843] 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile;

[0844] 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile;

[0845] 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0846] 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile;

[0847] 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; and

[0848] 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-1-yl)piperidin-2-yl)acetonitrile;

[0849] or a pharmaceutically acceptable salt thereof.

[0850] In another aspect, provided herein is a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

[0851] In one aspect, provided herein is a method of inhibiting a KRAS protein with a G12C mutation, the method comprising contacting a compound of the present disclosure with KRAS.

[0852] In another aspect, provided herein is a method of inhibiting a KRAS protein carrying a G12D mutation, the method comprising contacting a compound of the present disclosure with KRAS.

[0853] In yet another aspect, provided herein is a method of inhibiting a KRAS protein carrying a G12V mutation, the method comprising contacting a compound of the present disclosure with KRAS.

[0854] In one embodiment, the compound of the formulae herein is a compound of the formula or a pharmaceutically acceptable salt thereof.

[0855] It will also be appreciated that certain features of the invention described for clarity in the context of separate embodiments may also be provided in combination in a single embodiment (where such embodiments are intended to be combined as if written as multiple separate embodiments). Conversely, individual features of...

Claims

1. A compound of formula Ia: or a pharmaceutically acceptable salt thereof, in: Y is N or C; R 1 It is H; R 2 Selected from C 1-6 Alkyl and halo; wherein the C 1-6 The alkyl group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 22 Substituents substituted; Cy 1 Selected from C 6-10 aryl and an eight-membered, nine-membered or ten-membered fused bicyclic heteroaryl; wherein the C 6-10 Aryl and the eight-membered, nine-membered or ten-membered fused bicyclic heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 10 Substituents substituted; R 3 Selected from H, 4-10 membered heterocycloalkyl and OR f3 wherein the 4-10 membered heterocycloalkyl group is optionally substituted by 1, 2, 3 or 4 independently selected from R 30 Substituents substituted; R 5 Selected from H, C 1-6 Alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo and C(O)NR c5 R d5 wherein said C 1-6 Alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted; When Y is N, then R 6 does not exist; When Y is C, then R 6 Selected from H, C 1-6 Alkyl, 5-10 membered heteroaryl and C 6-10 Aryl-C 1-3 Alkylene; wherein the C 1-6 Alkyl, 5-10 membered heteroaryl and C 6-10 Aryl-C 1-3 Each alkylene group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 60 Substituents substituted; R 7 It is halogenated; Cy 2 is a 4-14 membered heterocycloalkyl group; wherein the 4-14 membered heterocycloalkyl group is optionally substituted by 1, 2, 3 or 4 independently selected R 20 Substituents substituted; Each R 10 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, CN, and OR a10 wherein said C 1-6 The alkyl group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 11 Substituents substituted; Each R 11 are independently halogenated; Each R 20 Independently selected from C 1-6 Alkyl and C(O)R b20 wherein said C 1-6 The alkyl group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 21 Substituents substituted; Each R 21 Independently selected from C 1-6 Haloalkyl, halo, CN, OR a21 and NR c21 R d21 ; Each R 22 It is CN; Each R 30 Independently selected from C 1-6 Alkyl, 4-10 membered heterocycloalkyl and NR c30 R d30 wherein said C 1-6 Alkyl and 4-10 membered heterocycloalkyl are each optionally substituted by 1, 2, 3 or 4 independently selected R 31 Substituents substituted; Each R 31 Independently C 1-6 alkyl; Each R 50 Independently selected from C 1-6 Alkyl, C 6-10 Aryl, OR a50 and NR c50 R d50 ; Each R 60 Independently selected from C 1-6 Alkyl, C(O)NR c60 R d60 and C(O)OR a60 ; Each R 61 independently selected from halo; R f3 Selected from C 1-6 Alkyl, the C 1-6 The alkyl group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 30 Substituents substituted; Each R c5 and R d5 Independently selected from H and C 1-6 Alkyl, the C 1-6 The alkyl group is optionally substituted by 1, 2, 3 or 4 groups independently selected from R 50 Substituents substituted; R a10 It is H; Each R b20 Independently selected from C 2-6 Alkenyl and C 2-6 Alkynyl; wherein the C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1, 2, 3 or 4 independently selected R 21 Substituents substituted; Each R a21 、R c21 and R d21 Independently selected from C 1-6 alkyl; Each R c30 and R d30 Independently selected from C 1-6 alkyl; Each R a50 、R c50 and R d50 Independently selected from H and C 1-6 alkyl; and Each R a60 、R c60 and R d60 Independently selected from C 1-6 Alkyl, wherein the C 1-6 The alkyl group is optionally substituted by 1, 2 or 3 groups independently selected from R 61 Substituents substituted; or any R attached to the same N atom c60 and R d60 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group; wherein the heterocycloalkyl and heteroaryl groups each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; wherein the N and S are optionally oxidized; and wherein the ring-forming carbon atoms of the heteroaryl and heterocycloalkyl groups are optionally substituted with oxo groups to form carbonyl groups.

2. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein Y is N or C; R 1 It is H; R 2 Selected from C 1-6 Alkyl and halo; wherein the C 1-6 The alkyl group is optionally substituted by 1, 2 or 3 groups independently selected from R 22 Substituents substituted; Cy 1 Selected from C 6-10 aryl and an eight-membered, nine-membered or ten-membered fused bicyclic heteroaryl; wherein the C 6-10 Aryl and eight-membered, nine-membered or ten-membered fused bicyclic heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 10 Substituents substituted; R 3 Selected from H, 4-10 membered heterocycloalkyl and OR f3 wherein the 4-10 membered heterocycloalkyl is optionally substituted by 1, 2 or 3 independently selected R 30 Substituents substituted; R 5 Selected from H, C 1-6 Alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo and C(O)NR c5 R d5 wherein said C 1-6 Alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 50 Substituents substituted; When Y is N, then R 6 does not exist; When Y is C, then R 6 Selected from H, C 1-6 Alkyl, 5-10 membered heteroaryl and C 6-10 Aryl-C 1-3 Alkylene; wherein the C 1-6 Alkyl, 5-10 membered heteroaryl and C 6-10 Aryl-C 1-3 Each alkylene group is optionally substituted by 1, 2 or 3 groups independently selected from R 60 Substituents substituted; R 7 It is halogenated; Cy 2 is a 4-14 membered heterocycloalkyl group; wherein the 4-14 membered heterocycloalkyl group is optionally substituted by 1 or 2 independently selected R 20 Substituents substituted; Each R 10 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, CN, and OR a10 wherein said C 1-6 The alkyl group is optionally substituted by 1, 2 or 3 groups independently selected from R 11 Substituents substituted; Each R 11 are independently halogenated; Each R 20 Independently selected from C 1-6 Alkyl and C(O)R b20 wherein said C 1-6 The alkyl group is optionally substituted by 1, 2 or 3 groups independently selected from R 21 Substituents substituted; Each R 21 Independently selected from C 1-6 Haloalkyl, halo, CN, OR a21 and NR c21 R d21 ; Each R 22 It is CN; Each R 30 Independently selected from C 1-6 Alkyl, 4-10 membered heterocycloalkyl and NR c30 R d30 wherein said C 1-6 Alkyl and 4-10 membered heterocycloalkyl are each optionally substituted by 1, 2 or 3 independently selected R 31 Substituents substituted; Each R 31 Independently C 1-6 alkyl; Each R 50 Independently selected from C 1-6 Alkyl, C 6-10 Aryl, OR a50 and NR c50 R d50 ; Each R 60 Independently selected from C 1-6 Alkyl, C(O)NR c60 R d60 and C(O)OR a60 ; Each R 61 independently selected from halo; R f3 It is C 1-6 Alkyl, which is optionally substituted by 1, 2 or 3 independently selected R 30 Substituents substituted; Each R c5 and R d5 Independently selected from H and C 1-6 Alkyl; wherein the C 1-6 The alkyl group is optionally substituted by 1, 2 or 3 groups independently selected from R 50 Substituents substituted; R a10 It is H; Each R b20 Independently selected from C 2-6 Alkenyl and C 2-6 Alkynyl; wherein the C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1 or 2 independently selected R 21 Substituents substituted; Each R a21 、R c21 and R d21 Independently C 1-6 alkyl; Each R c30 and R d30 Independently C 1-6 alkyl; Each R a50 、R c50 and R d50 Independently selected from H and C 1-6 alkyl; and Each R a60 、R c60 and R d60 Independently selected from C 1-6 Alkyl, wherein the C 1-6 The alkyl group is optionally substituted by 1, 2 or 3 groups independently selected from R 61 Substituents substituted; or any R attached to the same N atom c60 and R d60 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group.

3. The compound according to claim 1 or 2 or a pharmaceutically acceptable salt thereof, wherein Y is N or C; R 1 It is H; R 2 Selected from C 1-6 Alkyl and halo; wherein the C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 22 Substituents substituted; Cy 1 Selected from C 6-10 aryl and an eight-membered, nine-membered or ten-membered fused bicyclic heteroaryl; wherein the C 6-10 Aryl and eight-membered, nine-membered or ten-membered fused bicyclic heteroaryl are each optionally substituted by 1 or 2 independently selected R 10 Substituents substituted; R 3 Selected from H, 4-10 membered heterocycloalkyl and OR f3 wherein the 4-10 membered heterocycloalkyl group is optionally substituted by 1 or 2 independently selected R 30 Substituents substituted; R 5 Selected from H, C 1-6 Alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo and C(O)NR c5 R d5 wherein said C 1-6 Alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1 or 2 independently selected R 50 Substituents substituted; R 6 Selected from H, C 1-6 Alkyl, 5-10 membered heteroaryl and C 6-10 Aryl-C 1-3 Alkylene; wherein the C 1-6 Alkyl, 5-10 membered heteroaryl and C 6-10 Aryl-C 1-3 Each alkylene group is optionally substituted by 1, 2 or 3 groups independently selected from R 60 Substituents substituted; R 7 It is halogenated; Cy 2 is a 4-14 membered heterocycloalkyl group; wherein the 4-14 membered heterocycloalkyl group is optionally substituted by 1 or 2 independently selected R 20 Substituents substituted; Each R 10 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, halo, CN, and OR a10 ; Each R 20 Independently selected from C 1-6 Alkyl and C(O)R b20 wherein said C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 21 Substituents substituted; Each R 21 Independently selected from C 1-6 Haloalkyl, halo, CN, OR a21 and NR c21 R d21 ; Each R 22 It is CN; Each R 30 Independently selected from C 1-6 Alkyl, 4-10 membered heterocycloalkyl and NR c30 R d30 wherein said C 1-6 Alkyl and 4-10 membered heterocycloalkyl are each optionally substituted by 1 or 2 independently selected R 31 Substituents substituted; Each R 31 Independently C 1-6 alkyl; Each R 50 Independently selected from C 1-6 Alkyl, C 6-10 Aryl, OR a50 and NR c50 R d50 ; Each R 60 Independently selected from C 1-6 Alkyl, C(O)NR c60 R d60 and C(O)OR a60 ; R f3 It is C 1-6 Alkyl, which is optionally substituted by 1 or 2 independently selected from R 30 Substituents substituted; Each R c5 and R d5 Independently selected from H and C 1-6 Alkyl; wherein the C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 50 Substituents substituted; R a10 It is H; Each R b20 Independently selected from C 2-6 Alkenyl and C 2-6 Alkynyl; wherein the C 2-6 Alkenyl and C 2-6 Each alkynyl group is optionally substituted by 1 or 2 independently selected R 21 Substituents substituted; Each R a21 、R c21 and R d21 Independently C 1-6 alkyl; Each R c30 and R d30 Independently C 1-6 alkyl; Each R a50 、R c50 and R d50 Independently selected from H and C 1-6 alkyl; and Each R a60 、R c60 and R d60 Independently selected from C 1-6 alkyl; or any R attached to the same N atom c60 and R d60 Together with the nitrogen atom to which it is attached, it forms a 4-membered, 5-membered, 6-membered or 7-membered heterocycloalkyl group.

4. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the compound of formula Ia is a compound of formula II:

5. The compound according to any one of claims 1 to 3, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula Ia is a compound of Formula VI:

6. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 2 Selected from C 1-6 Alkyl and halo; wherein the C 1-6 The alkyl group is optionally substituted with one substituent, said substituent being R 22 .

7. The compound according to claim 6 or a pharmaceutically acceptable salt thereof, wherein R 22 It is CN.

8. The compound or pharmaceutically acceptable salt thereof according to any one of claims 1 to 7, wherein R 2 It is halogenated.

9. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein Cy 1 Selected from C 6-10 aryl and an eight-membered, nine-membered or ten-membered fused bicyclic heteroaryl; wherein the C 6-10 Aryl and eight-membered, nine-membered or ten-membered fused bicyclic heteroaryl are each optionally substituted by 1 or 2 independently selected R 10 substituted by a substituent.

10. The compound according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, wherein Cy 1 is optionally substituted by 1 or 2 independently selected from R 10 Substituents substituted C 6-10 Aryl.

11. The compound according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, wherein Cy 1 is optionally substituted by 1 or 2 independently selected from R 10 An eight-membered, nine-membered or ten-membered fused bicyclic heteroaryl group substituted with a substituent of 12. The compound according to any one of claims 1 to 11, or a pharmaceutically acceptable salt thereof, wherein R 10 Selected from C 1-3 Alkyl, C 1-3 Haloalkyl, halo, CN and OH.

13. The compound according to any one of claims 1 to 12, or a pharmaceutically acceptable salt thereof, wherein R 3 Selected from H, 4-6 membered heterocycloalkyl and OR f3 wherein the 4-6 membered heterocycloalkyl group is optionally substituted by 1 or 2 independently selected R 30 substituted by a substituent.

14. The compound or pharmaceutically acceptable salt thereof according to any one of claims 1 to 13, wherein each R 30 Independently selected from C 1-6 Alkyl, 4-6 membered heterocycloalkyl and NR c30 R d30 wherein said C 1-6 Alkyl and 4-6 membered heterocycloalkyl are each optionally substituted by 1 or 2 independently selected R 31 substituted by a substituent.

15. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 5 Selected from C 1-6 Alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo and C(O)NR c5 R d5 wherein said C 1-6 Alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 50 substituted by a substituent.

16. The compound according to any one of claims 1 to 14, or a pharmaceutically acceptable salt thereof, wherein R 5 It’s H.

17. The compound according to any one of claims 1 to 16, or a pharmaceutically acceptable salt thereof, wherein R 6 Selected from H, C 1-6 alkyl and 5-10 membered heteroaryl; wherein said C 1-6 Alkyl and 5-10 membered heteroaryl are each optionally substituted by 1, 2 or 3 groups independently selected from R 60 substituted by a substituent.

18. A compound according to any one of claims 1 to 17, or a pharmaceutically acceptable salt thereof, wherein Cy 2 is a 4-6 membered heterocycloalkyl group, which is optionally substituted by 1 or 2 independently selected 20 substituted by a substituent.

19. A compound according to any one of claims 1 to 18, or a pharmaceutically acceptable salt thereof, wherein Cy 2 Selected from Where n is 0, 1, or 2.

20. The compound of claim 19 or a pharmaceutically acceptable salt thereof, wherein Cy 2 It's Cy 2 -a1.

21. The compound of claim 19 or a pharmaceutically acceptable salt thereof, wherein Cy 2 It's Cy 2 -e.

22. A compound as described in any one of claims 1 to 21, or a pharmaceutically acceptable salt thereof, wherein each R 20 Independently selected from C 1-6 Alkyl and C(O)R b20 wherein said C 1-6 The alkyl group is optionally substituted by 1 or 2 independently selected R 21 substituted by a substituent.

23. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is 1-(4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)-piperidin-1-yl)prop-2-en-1-one; or 1-(4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one.

24. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-fluoroquinolin-8-yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-4-yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-methyl-2-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-6-fluoro-7-(3-methyl-2-(trifluoromethyl)phenyl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-2-yl)propanoic acid methyl ester; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-2-yl)-N,N-dimethylpropionamide; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-2-propyl-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-(1-methyl-1H-pyrazol-4-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-phenyl-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(pyridin-3-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-3-(2-methyloxazol-5-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(2-methylthiazol-5-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; and 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-3-(1-methyl-1H-pyrazol-4-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile.

25. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-(1-methyl-1H-pyrazol-3-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 3-(2-Benzyl-1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-3-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 1-(2-Azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-N-(2-hydroxyethyl)-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinoline-3-carboxamide; N-Benzyl-1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinoline-3-carboxamide; 3-(1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-3-(hydroxymethyl)-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 3-(1-((1R,4R,5S)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-4-ethoxy-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-pyrrolo[3,2-c]quinolin-2-yl)-N,N-dimethylpropionamide; methyl 3-(1-((1R,4R,5S)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-3-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-methoxy-1H-pyrrolo[3,2-c]quinolin-2-yl)propanoate; 3-(2-(3-(azetidin-1-yl)-3-oxopropyl)-1-(2-azabicyclo[ 2.1.1]hexan-5-yl)-6-fluoro-7-(7-fluoronaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propionitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 8-(1-((2S,4S)-1-(but-2-ynyl)-2-(cyanomethyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 8-(1-((2S,4S)-1-(but-2-ynyl)-2-(cyanomethyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthocarbonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynyl)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; and 2-((2S,4S)-1-(but-2-ynyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-1-yl)piperidin-2-yl)acetonitrile.

26. A pharmaceutical composition comprising the compound of any one of claims 1 to 25 or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient.

27. Use of the compound according to any one of claims 1 to 25 or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition according to claim 26, in the preparation of a medicament for inhibiting KRAS activity.

28. The use of claim 27, comprising administering the compound to a patient.

29. Use of the compound of any one of claims 1 to 25 or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition of claim 26, in the preparation of a medicament for treating a disease or condition associated with KRAS-interacting activity.

30. The use of claim 29, wherein the disease or disorder is an immune or inflammatory disorder.

31. The use of claim 30, wherein the immune or inflammatory disorder is a Ras-associated lymphoproliferative disorder or juvenile myelomonocytic leukemia caused by a somatic mutation of KRAS.

32. Use of the compound of any one of claims 1 to 25 or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition of claim 26, in the preparation of a medicament for treating cancer associated with KRAS activity.

33. The use of claim 32, wherein the cancer is selected from the group consisting of carcinoma, hematological cancer, sarcoma, and glioblastoma.

34. The use of claim 32, wherein the cancer is a hematological cancer selected from the group consisting of myeloproliferative neoplasms, myelodysplastic syndromes, acute myeloid leukemia, acute lymphoblastic leukemia, and multiple myeloma.

35. The use of claim 32, wherein the cancer is a carcinoma selected from pancreatic cancer, colorectal cancer, lung cancer, bladder cancer, stomach cancer, esophageal cancer, breast cancer, head and neck cancer, cervical cancer, skin cancer, and thyroid cancer.

36. Use of the compound of any one of claims 1 to 25 or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition of claim 26, in the preparation of a medicament for treating a disease or condition associated with the activity of a KRAS protein carrying a G12C mutation.

37. The use of claim 34, wherein the myelodysplastic syndrome is chronic and juvenile myelomonocytic leukemia.

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