Phantom cores, phantom devices, and their infusion methods for nuclear medicine

Abstract

This invention relates to phantom cores for nuclear medicine, each having at least two core regions coaxially arranged along its axial direction. Each core region contains at least six different diameter hotspot holes, with some hotspot hole diameters being identical across different core regions. A phantom device is also provided, comprising a phantom core and a barrel. The barrel includes a barrel body and a lid sealing the barrel body. The barrel body coaxially accommodates the phantom core for resolution assessment. This phantom core allows the phantom device to provide more resolution information in a single test, reducing the frequency of core replacement and refilling. A bubble-free automatic refilling method using an automatic refilling device is also provided, minimizing radiation hazards to operators even when replacing the phantom core for resolution assessments of different sizes.

Description

Technical Field

[0001] This invention relates to the field of medical imaging technology, and in particular to a phantom device for evaluating and testing the resolution of nuclear medicine imaging. Background Technology

[0002] For single-photon emission computed tomography (SPECT) and positron emission tomography (PET), spatial resolution has always been one of the most important performance indicators. Higher spatial resolution means that smaller lesions can be detected. Early-stage cancer lesions are often small in size; therefore, SPECT and PET with high spatial resolution can improve the detection rate of early-stage cancer.

[0003] The Derenzo resolution phantom is the most widely used resolution phantom in the field of nuclear medicine, such as Figure 1 As shown, the inner core of the phantom has a diameter of approximately 200 mm. Each inner core has six different diameter hot-sink holes, for example, 4.8, 6.4, 7.9, 9.5, 11.1, and 12.7 mm. During use, the hot-sink holes are filled with a radioactive solution and placed inside a sealed phantom. Image acquisition is then performed, and the image resolution is determined based on the images.

[0004] However, since each core has only six sets of holes, each test can only be conducted on these six fixed sizes. If it is necessary to test whether holes of other diameters can be distinguished, the core must be replaced, and the process refilled and repeated. This leads to several problems: firstly, air bubbles are easily generated during the filling process, affecting the test; secondly, several cores need to be prepared simultaneously; and thirdly, refilling exposes operators to a higher radiation dose and takes more time. Summary of the Invention

[0005] (a) Technical problems to be solved

[0006] To address the aforementioned problems of the prior art, this invention provides a nuclear medicine phantom core, a phantom device having the phantom core, and a perfusion method thereof. The phantom core has at least two core regions capable of performing resolution assessments at different sizes, with each core region capable of performing at least six resolution assessments. This allows for the provision of more resolution information for the device in a single test. Furthermore, the phantom device having the phantom core enables bubble-free automatic perfusion, minimizing radiation hazards to operators even when the phantom core is replaced for further resolution assessments at multiple sizes.

[0007] (II) Technical Solution

[0008] To achieve the above objectives, the main technical solutions adopted by the present invention include:

[0009] The first aspect provides a phantom core for nuclear medicine, the phantom core having at least two core regions arranged coaxially along the axial direction of the phantom core, each core region containing at least six different diameter hot foci.

[0010] Among them, the diameters of the heating holes in different inner core areas are partially the same.

[0011] Furthermore, the inner core region includes a first inner core region and a second inner core region;

[0012] Among them, the first inner core area and the second inner core area, where the hot stove holes of the same diameter are located, are connected, while the rest of the first inner core area and the second inner core area are not connected.

[0013] Furthermore, the inner core of the mold has a cylindrical structure and has: a first surface and a second surface located at both ends of the inner core of the mold, and a side surface connecting the first surface and the second surface;

[0014] The side surface of the inner core of the mold is provided with a fan-shaped groove for forming the non-connected arrangement of the first inner core area and the second inner core area.

[0015] The fan-shaped groove is parallel to the first surface and the second surface.

[0016] Furthermore, the central angle θ of the sector groove is 60°, 120°, 180°, 240° or 300°.

[0017] Furthermore, the hot stove hole is a through hole arranged along the axial direction of the inner core of the mold and passing through the first inner core area and the second inner core area respectively;

[0018] The first inner core area and the second inner core area each have at least 6 sub-regions, and the hot stove hole is disposed in the at least 6 sub-regions;

[0019] Within the same sub-region, the diameter of the hot stove holes is the same, and the number of hot stove holes is greater than or equal to 3. The distance between the centers of adjacent hot stove holes is twice the diameter of the hot stove hole.

[0020] Furthermore, the portion where the first inner core area and the second inner core area are connected includes at least one sub-region, and the hot stove hole is connected to the sub-region where the connection is made.

[0021] Furthermore, the non-connected portions of the first inner core region and the second inner core region each include at least two sub-regions, and the hot stove holes located in the non-connected sub-regions are not connected and have different diameters.

[0022] In a second aspect, a phantom device for nuclear medicine is provided, the phantom device comprising the phantom core and the barrel described in the first aspect;

[0023] The barrel includes a barrel body and a barrel lid used to seal the barrel body in the resolution evaluation.

[0024] The barrel body is a hollow cylindrical structure that is closed at one end and open at the other end, used to coaxially accommodate the core of the mold for resolution evaluation.

[0025] Furthermore, the open end and closed end of the barrel body are respectively provided with flange structures, and the maximum diameter of the flange structures is the same;

[0026] The flange structure of the closed end is a stepped disc. The center of the stepped disc has the maximum thickness of the flange structure of the closed end, and a threaded blind hole is provided at the center to fix the inner core of the mold to the inside of the barrel body by means of fasteners.

[0027] Thirdly, a method for infusing material based on the aforementioned phantom device is provided, comprising:

[0028] Water is injected into the barrel of the mold device using an automatic filling device until the barrel is full;

[0029] A radiopharmaceutical container containing a preset dose of radiopharmaceutical is connected in series to the liquid circulation pipeline of an automatic filling device, so that the automatic filling device, the barrel of the phantom device, and the radiopharmaceutical container form a liquid circulation channel for mixing radiopharmaceutical, thereby obtaining a uniformly mixed liquid radioactive source.

[0030] (III) Beneficial Effects

[0031] The beneficial effects of this invention are as follows: This invention provides a core for a nuclear medicine phantom, which has at least two core regions capable of performing resolution assessments at different sizes, and each core region capable of performing resolution assessments at least six sizes. This allows for the provision of more resolution information for the device in a single test, reducing the number of times the phantom core needs to be replaced and refilled.

[0032] Meanwhile, the phantom device with the phantom core provided by the present invention can perform bubble-free automatic injection with the help of existing automatic devices, and can minimize the radioactive hazards to operators even when the phantom core is replaced for more different resolution evaluations. Attached Figure Description

[0033] Figure 1 This is a schematic diagram of the core structure of a mold in the prior art;

[0034] Figure 2 This is a schematic diagram of the structure of the core inside the mold provided by the present invention;

[0035] Figure 3 This is a schematic cross-sectional view of the core of the mold provided in Embodiment 1 of the present invention, perpendicular to its axial direction;

[0036] Figure 4 for Figure 3 The shown is a side view of the inner core of the mold, viewed from one end face.

[0037] Figure 5 for Figure 3 The diagram shows a side view of the inner core of the mold as seen from its other end face.

[0038] Figure 6 This is a schematic diagram of a cross-section of the inner core of the mold provided in Embodiment 2 of the present invention, perpendicular to its axial direction.

[0039] Figure 7 This is a partial structural schematic diagram of the phantom device provided by the present invention;

[0040] Figure 8 A cross-sectional schematic diagram of the barrel body of the mold device provided by the present invention;

[0041] Figure 9 A schematic diagram of the barrel lid structure of the mold device provided by the present invention;

[0042] Figure 10 A cross-sectional schematic diagram of a barrel body equipped with a mold core, provided for the present invention;

[0043] Figure 11 A schematic diagram of the self-locking connector used in the barrel body provided by the present invention;

[0044] Figure 12 This is a schematic diagram of a hand-tightening sealing screw that can be used in the mold body device of the present invention.

[0045] [Explanation of Labels in the Attached Image]

[0046] 1: Hot air hole; 10: First inner core area; 20: Second inner core area;

[0047] 100: Inner core of the mold; 101: First surface; 102: Second surface; 103: Side surface; 104: Sector groove; 105: First circular through hole;

[0048] 200: Barrel body;

[0049] 210: Barrel body; 211: Flange structure; 212: Threaded blind hole; 213: Threaded through hole;

[0050] 220: Bucket lid; 221: Annular groove; 222: Water inlet hole; 223: Vent hole; 224: Self-locking connector; 225: Second circular through hole. Detailed Implementation

[0051] To better explain and facilitate understanding of the present invention, it will be described in detail below with reference to the accompanying drawings and specific embodiments. However, these specific embodiments do not limit the scope of the present invention in any way.

[0052] Single-photon emission computed tomography (SPECT) is a imaging system that introduces short-lived radiopharmaceuticals into the body orally or by injection. After metabolism, these radioactive substances create differences in radioactivity concentration inside and outside organs, or between lesions and normal tissues. Detectors identify these differences in human tissues, and computers process the data to form images. In addition to displaying structures, SPECT focuses on providing functional information about organs and diseased tissues, offering comprehensive information for the diagnosis and treatment of tumors.

[0053] Positron emission tomography (PET) is a non-invasive imaging technique that visualizes the function and metabolism of human organs. It works by injecting essential substances for biological metabolism into the body, such as glucose, proteins, nucleic acids, and fatty acids, labeled with short-lived radioactive isotopes (e.g., 18F, 11C). Utilizing the different metabolic states of different tissues—for example, in highly metabolic malignant tumor tissues where glucose metabolism is vigorous and accumulates in large quantities—these characteristics reflecting metabolic activity are captured in the images, thus enabling early diagnosis of diseases, especially tumors. PET is playing an increasingly important role as a functional imaging system.

[0054] For both imaging systems mentioned above, spatial resolution has always been one of the most important performance indicators. In the past, many researchers have focused on improving the spatial resolution of SPECT and PET, and the development of commercial SPECT and PET has consistently regarded improvements in spatial resolution as a key milestone. As mentioned in the background section, the Derenzo resolution phantom is currently the most widely used resolution phantom. Figure 1 As shown, the inner core of this model has six different diameter hot-stove holes, enabling simultaneous evaluation at six different resolutions. However, this clearly still cannot meet the usage requirements.

[0055] Based on this, the present invention provides a mold core, such as Figure 2As shown, the inner core of the mold has at least two inner core regions capable of performing evaluations at different resolutions. The inner core regions are arranged coaxially along the axial direction of the inner core of the mold. Each inner core region contains at least six different diameters of hot-sink holes to enable evaluations at at least six different sizes. The diameters of the hot-sink holes in different inner core regions are partially the same.

[0056] The phantom core with the above structure can provide more resolution information for the device in a single resolution evaluation test. This reduces the number of times the phantom device needs to be refilled due to phantom core replacement and also minimizes the radiation hazard to operators.

[0057] mold inner core

[0058] The specific structure of the core inside the mold will be described in detail in the following two embodiments. It should be understood that the description of the embodiments is only for illustrative purposes to help those skilled in the art understand the solution, and does not constitute a limitation on the scope of protection of the present invention.

[0059] Example 1

[0060] like Figure 2-5 As shown, this embodiment provides a phantom core 100 for nuclear medicine. The phantom core 100 is generally cylindrical and has a first surface 101 and a second surface 102 located at both ends of the phantom core 100, and a side surface 103 connecting the first surface 101 and the second surface 102. The phantom core 100 can be made of transparent acrylic (PMMA) material. Of course, other transparent materials, such as PC, PET, and ABS, can also be used as manufacturing materials for the phantom core 100.

[0061] The phantom core 100 provided in this embodiment has a first core region 10 and a second core region 20 capable of performing evaluations at different resolutions. The first core region 10 and the second core region 20 are coaxially arranged, and each of the two core regions has a heat-sensing hole 1 of six different diameters. Thus, the first core region 10 can perform evaluations at six different resolutions, and the second core region 20 can also perform evaluations at six different resolutions. The heat-sensing hole 1 is used to contain radioactive liquid during resolution evaluation, such as... Figure 2 As shown, in this embodiment, the hot stove hole 1 is a through hole structure arranged along the axial direction of the core 100 of the mold.

[0062] like Figure 3-5As shown, the first inner core area 10 and the second inner core area 20 each have 6 sub-regions, and the heating holes 1 are disposed in these 6 sub-regions. Within the same sub-region, the diameter of the heating holes 1 is the same, and the distance between the centers of adjacent heating holes 1 is twice the diameter of the heating hole 1. Thus, the heating holes 1 are arranged in at least an equilateral triangle in each sub-region, or it can be understood that the heating holes 1 are distributed along the two sides of a 60° sector of the sub-region. Since the desired resolution evaluation size is different, the diameter of the heating holes 1 is not specifically limited in this embodiment, but the number of heating holes 1 in each sub-region needs to be greater than or equal to 3. The diameters of the heating holes 1 in different sub-regions are different. This arrangement allows each inner core area to perform resolution evaluations of 6 different sizes. In this embodiment, the diameters of the six sets of hot-stove holes 1 on the first inner core area 10 of the mold core 100 can be 2.4mm, 3.2mm, 4.0mm, 4.8mm, 6.4mm, and 7.9mm respectively; and the diameters of the six sets of hot-stove holes 1 on the second inner core area 20 can be 1.6mm, 2.0mm, 2.4mm, 3.2mm, 4.0mm, and 4.8mm respectively.

[0063] In this embodiment, the first inner core region 10 and the second inner core region 20 have a connected portion, such as... Figure 3 As shown, each of the two inner core regions has four interconnected sub-regions. The heating holes 1 are also interconnected within these four interconnected sub-regions. Therefore, the heating holes 1 in the first inner core region 10 and the second inner core region 20 have the same diameter, enabling resolution evaluation at four different sizes. In this embodiment, the diameters of the four sets of heating holes 1 with the same diameter are: 2.4 mm, 3.2 mm, 4.0 mm, and 4.8 mm.

[0064] The remaining two sub-regions of the first inner core region 10 and the remaining two sub-regions of the second inner core region 20 are non-connected. In each of these non-connected sub-regions, the diameter of the heat sink hole 1 is different from the diameters of the heat sink holes 1 in the other sub-regions. Therefore, the four non-connected sub-regions of the first inner core region 10 and the second inner core region 20 can be evaluated for resolution at four different dimensions. Thus, the phantom core 100 provided in this embodiment can perform resolution evaluations at eight different dimensions in a single test.

[0065] The term "connected" merely indicates that there is no gap between the first inner core region 10 and the second inner core region 20, and does not imply any limitation on the molding method of the first inner core region 10 and the second inner core region 20. In this embodiment, it is preferable to integrally mold the mold core 100 to achieve a connected portion between the two inner core regions. Of course, other molding methods can also be used to achieve a connected portion between the two inner core regions.

[0066] In this embodiment, the four non-connected sub-regions are formed by creating fan-shaped grooves 104 on the side surface 103 of the mold core 100. The fan-shaped grooves 104 are parallel to the first surface 101 and the second surface 102. The width of the fan-shaped grooves 104 can be 6 mm, which can be determined based on the machining tool, as long as the first inner core region 10 and the second inner core region 20 are in a non-connected state. The central angle θ of the fan-shaped grooves 104 is 120°. That is, the first inner core region 10 and the second inner core region 20 each have two sub-regions that are not in a connected state. Of course, it is understood that the central angle θ of the fan-shaped grooves 104 can be greater than or equal to 120°. However, considering factors such as the machining process and the overall strength of the mold core 100, in this embodiment, the central angle θ of the fan-shaped grooves is 120°, or as mentioned in the following embodiments, 180°, or of course, 240° or 300°.

[0067] In this embodiment, the first inner core region 10 and the second inner core region 20 are integrally formed, or connected. The heating hole 1 can be a through-hole structure connecting the first surface 101 and the second surface 102 of the inner core 100. For the other four sub-regions corresponding to the fan-shaped groove 104, the heating hole 1 on the first inner core region 10 can be a through-hole structure connecting the first surface 101 and the fan-shaped groove 104, and the heating hole 1 on the second inner core region 20 can be a through-hole structure connecting the second surface 102 and the fan-shaped groove 104. The aforementioned through-hole structures will be used to contain radioactive liquid when the inner core 100 is in use, that is, when performing resolution evaluation.

[0068] The mold core 100 needs to be placed inside the mold assembly during use, which will be described in detail below. Therefore, the mold core 100 provided in this embodiment can have an outer diameter of 73.0–73.9 mm. Of course, it can be slightly smaller than the inner diameter of the barrel in the mold assembly to be placed inside, facilitating insertion into the barrel. The height of the mold core 100 can be 60 mm, or determined according to the size of the barrel to be inserted. Furthermore, a first circular through hole 105 with a diameter of 8 mm is provided on the axis of the cylindrical structure of the mold core 100. Figure 3-5 As shown, the first circular through hole 105 connects the first surface 101 and the second surface 102 of the inner core 100 of the mold, and is used to fix the inner core 100 of the mold to the mold device by means of threaded fasteners such as screws after the inner core 100 of the mold is placed in the mold device.

[0069] The phantom core 100 provided in this embodiment, by setting more than 6 different diameter hot stove holes 1 on a single phantom core 100, can provide more resolution information in a single resolution assessment, reducing the number of times the core needs to be replaced and refilled with radioactive liquid, and reducing the risk of operators being exposed to a radioactive environment.

[0070] Example 2

[0071] This embodiment provides another mold core 100 with a structure similar to that of Embodiment 1. In the following description, parts whose structure is consistent with that of the mold core 100 of Embodiment 1 will not be repeated. Only the parts whose structure is different will be described in detail. The same reference numerals are used for parts with the same name.

[0072] The core 100 of the phantom in this embodiment also has a cylindrical structure, but the difference lies in the setting of the fan-shaped groove 104. In this embodiment, the central angle θ of the fan-shaped groove 104 is 180°, that is, a fan-shaped groove 104 with half a cross-sectional shape is provided in the middle region of the entire phantom core 100 along its axial direction, on a cross-section that is roughly perpendicular to the axial direction of the phantom core 100. One advantage of this structure of the fan-shaped groove 104 compared to the fan-shaped groove 104 in Embodiment 1 is that it is easier to manufacture. Another advantage is that the non-connected parts of the phantom core 100 have a total of 6 sub-regions located on the first inner core region 10 and the second inner core region 20, respectively. The diameter of the hot stove hole 1 in each sub-region is different, which allows the phantom core 100 to complete the judgment of 9 different resolutions in a single resolution evaluation. This further improves the utilization efficiency of the phantom core 100 and further reduces the number of times the phantom core needs to be replaced and refilled, as well as the risk of operators being passively exposed to a radioactive environment.

[0073] In this embodiment, the diameters of the heating holes 1 on the six sub-regions of the first inner core region can be 2.4mm, 3.2mm, 4.0mm, 4.8mm, 6.4mm, and 7.9mm, respectively; the diameters of the heating holes 1 on the six sub-regions of the first inner core region can be 1.2mm, 1.6mm, 2.0mm, 2.4mm, 3.2mm, 4.0mm, and 4.8mm, respectively. Heating holes of the same diameter are located in the integral part of the inner core 100 of the mold; the areas separated by the fan-shaped groove 104 contain six groups of heating holes 1 with different diameters.

[0074] Furthermore, the central angle θ of the sector groove 104 can also be 60°, so that the non-connected parts each have only one sub-region in the first inner core region 10 and the second inner core region 20, that is, only one set of hot stove holes 1 respectively. However, considering the ease of processing and the strength of the structure, the sector groove structure with a central angle θ of 120° and 180° is undoubtedly preferred.

[0075] phantom device

[0076] The mold assembly provided by this invention includes the mold core 100 described in embodiments 1 and 2 above, and also includes a barrel 200, as shown below. Figure 7 As shown. The barrel 200 includes a barrel body 210 and a barrel lid 220 for sealing the barrel body during resolution evaluation; the barrel body 210 is a hollow cylindrical structure with one end closed and the other end open, used to coaxially accommodate the mold core 100 mentioned in the above embodiments for resolution evaluation.

[0077] In this embodiment, the barrel body 210 is made of transparent acrylic material. Of course, other transparent materials, such as PC, PET, and ABS, can also be used. The total height of the barrel body 210 can be adjusted according to the height of the core 100 placed inside the mold as needed. In this embodiment, the total height of the barrel body 210 can be 86mm, the outer diameter is 80mm, and the wall thickness is 3mm. The acrylic tube processed into the barrel body 210 has a flat end face, and the cylindrical surface does not need to be processed. This maintains the transparency of the acrylic surface while reducing workload and lowering costs.

[0078] The open and closed ends of the barrel body 210 are respectively provided with flange structures 211, and the maximum diameter of the flange structures 211 is the same. The purpose of having the same maximum diameter for the flange structures 211 at both ends of the barrel body 210 is to allow the mold device with this structure provided by the present invention to be easily placed horizontally during use. After placement, the axis and bed surface of the mold body 210 remain in a horizontal position, which is more conducive to image acquisition. In this embodiment, the maximum diameter of the flange structure 211 is selected as 100mm.

[0079] like Figure 8 As shown, the flange structure 211 and the barrel body 210 are made of the same material. The flange structure 211 located at the closed end, that is, the bottom end of the barrel body 210, is a stepped disc. The center of the stepped disc has the maximum thickness of the flange structure at the closed end, which is 16mm in this embodiment, and is also the third step. The thickness of the second step is 10mm, and the diameter is 74mm, which can match the inner diameter of the barrel body 210 in this embodiment. The thickness of the first step, that is, the maximum diameter of the flange structure 211, is 6mm.

[0080] Furthermore, at the center of the circle, that is, at the third step where the closed end flange structure has the maximum thickness, a threaded blind hole 212 is provided, which can fix the aforementioned mold core 100 to the inside of the barrel body 210 by means of fasteners. In this embodiment, the threaded blind hole 212 is an M6 threaded hole with an effective thread depth of 10mm.

[0081] The flange structure 211 located at the open end of the barrel body 210 has a thickness of 8mm in this embodiment, an outer diameter of 100mm as described above, and an inner diameter of 80mm, which is the same as the outer diameter of the acrylic tube used to prepare the barrel body 210. This allows the flange structure 211 to fit into the barrel body. Six or eight M5 threaded through holes 213 are evenly spaced on the flange structure, with the center of each threaded through hole 213 located on a circumference with a diameter of 90mm.

[0082] During the manufacturing process, the aforementioned flange structure 211 can be bonded to both ends of the barrel body 211 using specialized acrylic adhesive, ensuring strength and sealing after bonding. The flange structure 211 located at the bottom of the barrel body 211 also forms the closed end of the barrel body 210.

[0083] like Figure 9 As shown, the lid 220 of the mold device provided in this embodiment can also be made of acrylic, with a diameter of 100mm and a thickness of 10mm. On the side facing the barrel body 210, corresponding to the flange structure 211 at the open end, the lid 220 is provided with 6 or 8 second circular through holes 225 at equal intervals, the diameter of the second circular through holes 225 being 5.5mm; in addition, the lid 220 is also provided with an annular groove 221 corresponding to the flange structure 211 for accommodating O-rings to seal the barrel body 210, the annular groove 221 having an inner diameter of 82mm, a groove width of 3.2mm, and a depth of 2.5mm. In this embodiment, the lid 220 is also provided with at least one water injection hole 222 for injecting water into the barrel body 210, and at least one vent hole 223 for venting gas from the barrel body 210. The water injection hole 222 is provided with a self-locking connector 224, such as Figure 11 As shown, the connector 224 has a self-locking structure, allowing for automatic filling of the mold device via connection to a water pipe. It is used with a corresponding standard pipe fitting during automatic filling. Alternatively, if manual filling is used, the water inlet 222 can also be used with a hand-tightening plug, such as... Figure 12 As shown.

[0084] The dimensions of the mold core 100 and barrel 200 described above are only one design embodiment. The diameter and other dimensions of the barrel and the mold core 100 and barrel 200 can be expanded, as long as their inner and outer diameters can be used in combination. Currently, the mold core can be made with an outer diameter of 200mm, and the inner diameter of the barrel 200 can be made slightly larger than 200mm.

[0085] Infusion method

[0086] The phantom device provided by this invention can achieve bubble-free injection using existing automatic injection devices, including the following steps:

[0087] First, water is injected into the barrel of the mold device using an automatic filling device until the barrel is full;

[0088] Secondly, a radiopharmaceutical container containing a preset dose of radiopharmaceutical is connected in series to the liquid circulation pipeline of the automatic filling device, so that the automatic filling device, the barrel of the phantom device and the radiopharmaceutical container form a liquid circulation channel for mixing radiopharmaceutical, thereby obtaining a uniformly mixed liquid radioactive source.

[0089] The automatic infusion device is prior art and can be achieved by any existing device capable of automatic infusion, such as the infusion system disclosed in the applicant's prior application CN202010074207.9, the contents of which are incorporated herein by reference.

[0090] Specifically, the automatic injection device includes components such as a power unit, a reversing valve, a gas washing bottle for discharging gas from the liquid circulation pipeline, a needle holder, and a radiopharmaceutical container.

[0091] At the beginning of the injection, the mold core 100 provided in Embodiment 1 or Embodiment 2 is inserted into the barrel body 210 of the mold device provided by the present invention. Then, using an M6x65 screw, the mold core 100 is threadedly connected to the flange structure 211 at the closed end of the barrel body 200 through the first circular through hole 105 of the mold core 100, thereby fixing the mold core 100 inside the barrel body 200.

[0092] Subsequently, the lid 220 is sealed to the open end of the barrel body 200. This sealing connection does not refer to a completely airtight connection, but rather to ensuring that the barrel body 200 will not leak after subsequent liquid filling. Specifically, an M5x16 screw is used, threaded through the second circular through-hole 225 on the lid 220, and then threaded into the threaded through-hole 213 of the flange structure 211 at the open end of the barrel body 210, thus sealing the lid 220 to the open end of the barrel body 210. During screw tightening, care must be taken to ensure smooth tightening so that the O-ring is evenly compressed by the screw tightening force, thereby ensuring that the barrel body 210 does not leak during subsequent liquid filling.

[0093] After the filling begins, water is first injected into the barrel 200 through the power component, reversing valve and gas washing bottle of the automatic filling device with the help of an external water source, and then through the self-locking connector 224 connected to the water injection hole 222 of the barrel cover 220 until the barrel 200 is full.

[0094] Then, the radiopharmaceutical container containing a preset dose of radiopharmaceutical is connected in series to the liquid circulation pipeline of the automatic filling device through a needle seat that is pre-connected to the above-mentioned liquid circulation pipeline. The flow path into the gas washing bottle is changed by the reversing valve, so that the radiopharmaceutical in the radiopharmaceutical container enters the circulating liquid channel and is circulated and mixed evenly with the original water in the channel, and is injected into the barrel 200 of the phantom device to obtain a uniformly mixed liquid radioactive source.

[0095] Use with the corresponding standard pipe fittings during automatic filling.

[0096] Manual phantom filling devices present significant challenges in controlling bubble formation and expose operators to radioactive environments, potentially causing harm. However, the phantom filling device provided by this invention, combined with existing automated filling equipment, enables bubble-free filling while minimizing radiation exposure to operators.

[0097] If manual filling is used, the operator needs to unscrew the two hand-tightening sealing screws on the bucket lid 220. The hand-tightening sealing screws are characterized by a groove at the bottom, with an O-ring sealing ring inside the groove. Figure 12 As shown. Then, a certain concentration of FDG solution is injected using an injector. Due to the structure of multiple hot-pore holes in the core of the mold inside the barrel 200, even with extreme care throughout the injection process, it is difficult to avoid the generation of air bubbles. After the mold body 200 is filled, the operator needs to tighten the two hand-tightening sealing screws again. At this point, the mold device has completed the injection and can be scanned for imaging.

[0098] The phantom device provided by this invention can use a quick-connect pipe joint with a self-locking structure to replace the hand-tightening sealing screw. The water pipe can be inserted into this quick-connect pipe structure and self-lock, thereby achieving automatic filling and forming a high-quality, bubble-free phantom. After the phantom device completes filling, scanning imaging can be performed. This not only provides more resolution information for the equipment in a single test, but also minimizes the radiation hazard to operators.

[0099] In the description of this specification, the terms "one embodiment," "some embodiments," "embodiment," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0100] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make modifications, alterations, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A phantom core for nuclear medicine, characterized in that: The inner core of the mold has at least two inner core regions, which are arranged coaxially along the axial direction of the inner core of the mold. Each inner core region contains at least six types of hot hole diameters, and each inner core region is evaluated for at least six different sizes to reduce the number of times the inner core of the mold needs to be replaced and refilled. Among them, the diameters of the heating holes in different inner core areas are partially the same; The core of the phantom is the core of a Derenzo resolution phantom in a single-photon emission computed tomography system or a positron emission tomography system.

2. The mold core as described in claim 1, characterized in that: The inner core region includes a first inner core region and a second inner core region; Among them, the first inner core area and the second inner core area, where the hot stove holes of the same diameter are located, are connected, while the rest of the first inner core area and the second inner core area are not connected.

3. The mold core as described in claim 2, characterized in that: The inner core of the mold is cylindrical in shape and has: a first surface and a second surface located at both ends of the inner core of the mold, and a side surface connecting the first surface and the second surface. The side surface of the inner core of the mold is provided with a fan-shaped groove for forming the non-connected arrangement of the first inner core area and the second inner core area. The fan-shaped groove is parallel to the first surface and the second surface.

4. The mold core as described in claim 3, characterized in that: The central angle θ of the sector groove is 60°, 120°, 180°, 240° or 300°.

5. The mold core as described in claim 2, characterized in that: The hot hole is a through hole arranged along the axial direction of the inner core of the mold and passing through the first inner core area and the second inner core area respectively. The first inner core area and the second inner core area each have at least 6 sub-regions, and the hot stove hole is disposed in the at least 6 sub-regions; Within the same sub-region, the diameter of the hot stove holes is the same, and the number of hot stove holes is greater than or equal to 3. The distance between the centers of adjacent hot stove holes is twice the diameter of the hot stove hole.

6. The mold core as described in claim 5, characterized in that: The portion where the first inner core area and the second inner core area are connected includes at least one sub-region, and the hot stove hole is connected to the sub-region where the connection is made.

7. The mold core as described in claim 5, characterized in that: The non-connected portions of the first inner core area and the second inner core area each include at least two sub-regions, and the hot stove holes located in the non-connected sub-regions are not connected and have different diameters.

8. A phantom device for nuclear medicine, characterized in that: The mold assembly includes the mold core and the barrel body as described in any one of claims 1-7; The barrel includes a barrel body and a barrel lid used to seal the barrel body in the resolution evaluation. The barrel body is a hollow cylindrical structure that is closed at one end and open at the other end, used to coaxially accommodate the core of the mold for resolution evaluation.

9. The phantom device as described in claim 8, characterized in that: The open end and closed end of the barrel body are respectively provided with flange structures, and the maximum diameter of the flange structures is the same; The flange structure of the closed end is a stepped disc. The center of the stepped disc has the maximum thickness of the flange structure of the closed end, and a threaded blind hole is provided at the center to fix the inner core of the mold to the inside of the barrel body by means of fasteners.

10. A method for injecting a phantom device based on claim 8 or 9, characterized in that, include: Water is injected into the barrel of the mold device using an automatic filling device until the barrel is full; A radiopharmaceutical container containing a preset dose of radiopharmaceutical is connected in series to the liquid circulation pipeline of an automatic filling device, so that the automatic filling device, the barrel of the phantom device, and the radiopharmaceutical container form a liquid circulation channel for mixing radiopharmaceutical, thereby obtaining a uniformly mixed liquid radioactive source.

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