A device and method for large-scale production of highly monodisperse droplets

Abstract

The present invention discloses a high-monodispersity droplet scale production device and method, including a monodisperse droplet generation device, a water phase supply system, an oil phase supply system, an oil-water separation system and a finished product collection system, wherein the monodisperse droplet generation device includes a housing and a drive shaft and a constant volume disk rotatably arranged in the housing, wherein the constant volume disk is provided with a plurality of constant volume holes; a feeder body and a collection body are provided in the housing at the upper and lower sides of the constant volume disk, wherein the feeder body is provided with cross-arranged oil phase channels A and water phase channels A, wherein the collection body is cross-arranged with oil phase channels B and water phase channels B, wherein the oil phase channels A and oil phase channels B are correspondingly arranged at the upper and lower sides of the constant volume holes, and the water phase channels A and water phase channels B are correspondingly arranged at the upper and lower sides of the constant volume holes; the water phase supply system is connected to the water phase channel A, the oil phase supply system is connected to the oil phase channel A, the oil-water separation system is connected to the oil phase channel B, and the finished product collection system is connected to the water phase channel B. The present invention can improve the dispersion performance and production efficiency of monodisperse droplets.

Description

Technical Field

[0001] The present invention relates to the field of highly dispersive droplet production, and in particular to a device and method for large-scale production of highly monodisperse droplets. Background Art

[0002] Highly monodisperse droplets can be used to synthesize various functional microspheres and are widely used in the fields of biology, medicine, pharmaceuticals, and the environment. At present, highly monodisperse droplets are generally produced using droplet microfluidics technology, which can prepare highly monodisperse droplets in microchannels. However, the output of a single microfluidic device is extremely low. To achieve the scale of industrial application, thousands or even tens of thousands of droplet preparation microfluidic units need to run simultaneously, requiring a large number of fluid pumps, fluid storage tanks, and related infrastructure. The equipment investment cost is high. At the same time, the integrated amplification of droplet microfluidics has brought about problems such as reduced monodispersity and difficulty in controlling the production process. The modeling of highly monodisperse droplets has become a technical difficulty for the industrial application of microdroplets. Summary of the invention

[0003] Purpose of the invention: The purpose of the present invention is to provide a device and method for large-scale production of highly monodisperse droplets to improve the dispersion performance and production efficiency of monodisperse droplets.

[0004] Technical solution: The invention provides a large-scale production device for highly monodisperse droplets, the large-scale production device comprising:

[0005] A monodisperse droplet generating device, the monodisperse droplet generating device comprises a shell and a cover plate correspondingly arranged at the top of the shell; a driving shaft is rotatably provided in the shell and a constant volume disk is fixedly mounted therein, a plurality of constant volume holes are opened on the surface of the constant volume disk; a driving mechanism is provided corresponding to the driving shaft; a feeder body and a collecting body are provided in the shell and are attached to the upper and lower sides of the constant volume disk, the feeder body is provided with cross-arranged oil phase channels A and water phase channels A, the collecting body is provided with cross-arranged oil phase channels B and water phase channels B, the oil phase channels A and oil phase channels B are correspondingly arranged at the upper and lower sides of the constant volume holes, and the water phase channels A and water phase channels B are correspondingly arranged at the upper and lower sides of the constant volume holes;

[0006] A water phase supply system, the water phase supply system is connected to the water phase channel A and supplies a water phase solution in a quantitative manner;

[0007] An oil phase supply system, the oil phase supply system is connected to the oil phase channel A and supplies the oil phase solution quantitatively;

[0008] An oil-water separation system, which is connected to the oil phase channel B and separates the oil phase and the water phase for recycling;

[0009] A finished product collection system is connected to the water phase channel B and collects highly monodisperse droplet products.

[0010] Preferably, the oil phase channel A, water phase channel A, oil phase channel B, and water phase channel B all include an annular distribution pipe, a main pipe arranged on the annular distribution pipe, and a horizontal distribution pipe radially arranged along the circumference of the annular distribution pipe and along the feed body or the aggregate body, and the horizontal distribution pipe is vertically provided with a plurality of longitudinal pipes.

[0011] Preferably, the constant volume holes are arranged along the radial direction of the constant volume disk corresponding to the longitudinal pipeline ports.

[0012] Preferably, a lower positioning pin is provided at the bottom of the shell, and the aggregate body is clamped in the shell through the lower positioning pin; the cover plate is provided with an upper positioning pin, and the lower end of the upper positioning pin is fixedly pressed against the upper end of the feed body by a compression spring.

[0013] Preferably, the driving mechanism includes a reducer and a driving motor connected to the driving shaft via a coupling.

[0014] Preferably, the water phase supply system comprises a water phase storage tank and a water phase feed pump, and the water phase feed pump quantitatively transports the water phase solution in the water phase storage tank to the water phase channel A in the feed body.

[0015] Preferably, the oil phase supply system comprises an oil phase storage tank and an oil phase feed pump, and the oil phase feed pump quantitatively transports the oil phase solution in the oil phase storage tank to the oil phase channel A in the feed body.

[0016] Preferably, the oil-water separation system includes an oil-water separator and a water phase recovery tank and an oil phase recovery tank respectively connected to the oil-water separator, the water phase recovery tank returns liquid to the water phase supply system through a water phase recycling pump, and the oil phase recovery tank returns liquid to the oil phase supply system through an oil phase recycling pump.

[0017] Preferably, the finished product collection system comprises a monodisperse droplet product tank connected to the water phase channel B through a droplet product delivery pipe.

[0018] A method for large-scale production of highly monodisperse droplets, using a large-scale production device for highly monodisperse droplets, comprises the following steps:

[0019] Step 1: Set the operating frequencies of the oil phase feed pump and the water phase feed pump in the oil phase supply system and the water phase supply system, and set the operating frequency of the drive motor in the drive mechanism accordingly;

[0020] Step 2: Start the oil phase supply system and the water phase supply system, and fill the oil phase and water phase into the constant volume hole of the constant volume plate through the oil phase channel A and the water phase channel A in the feed body respectively;

[0021] Step 3: The oil phase supply system and the water phase supply system stop injecting liquid into the fixed volume hole of the fixed volume plate through the oil phase feed pump and the water phase feed pump, and control the fixed volume plate to rotate at a certain angle along with the driving shaft through the driving motor, and the droplets in the fixed volume hole move along with the fixed volume plate;

[0022] Step 4: The constant volume disk rotates along with the driving shaft until the constant volume hole is aligned with the longitudinal pipe outlet end of the feed body again, and the constant volume disk stops rotating;

[0023] Step 5: Start the oil phase supply system and the water phase supply system, and inject the oil phase and the water phase into the constant volume hole of the constant volume plate through the oil phase channel A and the water phase channel A in the feed body, respectively. The oil phase previously filled in the constant volume hole is blown out by the subsequently injected water phase, and the water phase previously filled in the constant volume hole is blown out by the subsequently injected oil phase;

[0024] Step 6: Repeat steps 2-5 cyclically to continuously produce monodisperse droplets, and collect and store the monodisperse droplet products through a finished product collection system.

[0025] Beneficial effects: Compared with the prior art, the present invention has the following outstanding advantages:

[0026] 1. The monodisperse droplet generating device of the present invention drives the constant volume disk to rotate at a certain speed through a driving mechanism, and realizes mutual blowing of two-phase droplets through the cooperation of the oil phase channel A and the water phase channel A in the aggregate body, thereby efficiently producing monodisperse droplets;

[0027] 2. The monodisperse droplet generating device of the present invention realizes the sealed connection between the feed body, the constant volume plate and the collecting body, which can prevent the liquid from spilling and leaking; the droplet flow rate is stable during the production process, and the sensitivity requirements for the liquid pump and other conveying equipment are low, and monodisperse droplets can be quickly generated;

[0028] 3. The feed body and the collecting body of the present invention adopt a multi-channel structure, and the yield of monodisperse droplets is increased by changing the diameter of the constant volume plate, the number and diameter of the constant volume holes. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 It is a schematic diagram of the structure of a large-scale production device of the present invention;

[0030] Figure 2 for Figure 1 Schematic diagram of the three-dimensional structure of the monodisperse droplet generation device;

[0031] Figure 3 for Figure 2 A cross-sectional view of the lower structure of the monodisperse droplet generating device;

[0032] Figure 4 for Figure 3 Schematic diagram of the connection structure between the middle feed body, the collecting body and the constant volume tray;

[0033] Figure 5 for Figure 4 Schematic diagram of the structure of the middle constant volume tray;

[0034] Figure 6 for Figure 4 Schematic diagram of the internal pipeline structure of the feeder body or the aggregate body;

[0035] Figure 7 This is a schematic structural diagram of step 2 in the method for producing monodisperse droplets of the present invention;

[0036] Figure 8 This is a schematic structural diagram of step 3 in the method for producing monodisperse droplets of the present invention;

[0037] Fig. 9 This is a schematic structural diagram of step 4 in the method for producing monodisperse droplets of the present invention;

[0038] Fig.10 This is a schematic structural diagram of step 5 in the method for producing monodisperse droplets of the present invention;

[0039] Fig.11 It is a schematic structural diagram of step 6 in the method for producing monodisperse droplets of the present invention.

[0040] Reference numerals:

[0041] 100. Large-scale production equipment;

[0042] 1. Monodisperse droplet generating device; 101. driving motor; 102. speed reducer; 103. coupling; 104. driving shaft; 105. supporting bearing; 106. cover plate; 107. upper positioning pin; 108. housing; 109. liquid inlet end pipe; 110. liquid discharge end pipe; 111. pressing spring; 112. feed body; 113. collecting body; 114. constant volume plate; 115. lower positioning pin; 116. oil phase channel A; 117. water phase channel A; 118. oil phase channel B; 119. water phase channel B; 1110. constant volume hole; 1111. main pipeline; 1112. annular distribution pipeline; 1113. horizontal distribution pipeline; 1114. longitudinal pipeline;

[0043] 2. Oil phase storage tank; 3. Water phase storage tank; 4. Workbench; 5. Downpipe; 6. Feed pipe; 7. Oil phase feed pump; 8. Water phase feed pump; 9. Water phase reuse pump; 10. Oil phase reuse pump; 11. Return liquid pipe; 12. Water phase recovery tank; 13. Oil phase recovery tank; 14. Oil phase overflow pipe; 15. Oil-water separator; 16. Monodisperse droplet product tank; 17. Droplet product delivery pipe. DETAILED DESCRIPTION

[0044] To make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the following will be combined with the appended drawings of the embodiments of the present invention. Figure 1-11 , the technical scheme of the embodiment of the present invention is clearly and completely described. Obviously, the described embodiment is a part of the embodiment of the present invention, not all of the embodiments. Based on the described embodiment of the present invention, all other embodiments obtained by ordinary technicians in this field belong to the scope of protection of the present invention.

[0045] like Figure 1-5 As shown, a high-monodispersity droplet large-scale production device of the present invention, the large-scale production device 100 includes a workbench 4 and a monodisperse droplet generating device 1 arranged on a workbench plate of the workbench, the monodisperse droplet generating device 1 includes a shell 108 and a cover plate 106 corresponding to the top of the shell, the workbench plate is provided with mounting holes, and the connecting flange arranged on the top of the shell 108 is fixedly connected to the cover plate 106 by connecting bolts. Support bearings 105 are respectively provided at the center of the bottom end of the shell 108 and the center of the top end of the cover plate 106. The driving shaft 104 is rotatably installed on the two sets of support bearings 105. The driving shaft 104 is located in the shell 108 and is fixedly mounted with a constant volume disk 114. A plurality of constant volume holes 1110 are opened on the disk surface of the constant volume disk 114. Specifically, the constant volume holes 1110 are radially distributed along the constant volume disk 114. The number and diameter of the constant volume holes 1110 can be set according to demand. For example, if the diameter of monodisperse droplets needs to be increased, the diameter of the constant volume holes needs to be increased accordingly; if the output of monodisperse droplets needs to be increased, the diameter of the constant volume disk needs to be increased.

[0046] like Figure 2-4 As shown, a driving mechanism is provided corresponding to the driving shaft 104, and the driving mechanism includes a reducer 102 and a driving motor 101 connected to the upper end of the driving shaft 104 through a coupling 103. The driving motor 101 can be a servo motor or a stepping motor. The driving motor can drive the driving shaft to rotate through the reducer, thereby controlling the constant volume disk 114 to rotate along the axis. An installation cavity is provided in the housing 108, and a feeder body 112 and a collection body 113 are provided in the installation cavity correspondingly. The feeder body 112 is correspondingly arranged on the upper side of the constant volume disk, and the collection body 113 is correspondingly arranged on the lower side of the constant volume disk. Two groups of lower positioning pins 115 are provided at the bottom of the inner cavity of the shell 108, and positioning holes are correspondingly provided at the bottom of the aggregate body 113. The positioning holes of the aggregate body 113 and the lower positioning pins 115 are correspondingly clamped at the bottom of the shell; the cover plate 106 is provided with two groups of upper positioning pins 107, and positioning holes are correspondingly provided at the top of the feed body 112. The lower end of the upper positioning pin 107 is fixed and pressed to the upper end of the feed body 112 by a clamping spring 111. The feed body 112, the constant volume disk 114 and the aggregate body 113 can be tightly fitted through the clamping spring 111. Without affecting the rotation of the constant volume disk, the sealing performance of the combination of the feed body, the aggregate body and the constant volume disk is improved to prevent leakage.

[0047] like Figure 4 and Figure 6 As shown, the feed body 112 is provided with cross-arranged oil phase channels A116 and water phase channels A117, and the aggregate body 113 is provided with cross-arranged oil phase channels B118 and water phase channels B119; the oil phase channel A116, the water phase channel A117, the oil phase channel B118, and the water phase channel B119 all include an annular distribution pipe 1112, a main pipe 1111 arranged on the annular distribution pipe, and a horizontal distribution pipe 1113 radially arranged along the circumference of the annular distribution pipe and along the feed body 112 or the aggregate body 113, and the horizontal distribution pipe 1113 is vertically provided with a plurality of longitudinal pipes 1114. Specifically, the oil phase channel A 116 in the feed body is set in the opposite direction to the oil phase channel B 118 in the aggregate body 113, and the water phase channel A 117 in the feed body is set in the opposite direction to the water phase channel B 119 in the aggregate body; the inlets of the main pipelines 1111 of the oil phase channel A116 and the water phase channel A117 are connected to the liquid inlet end pipe 109, and the outlets of the main pipelines of the oil phase channel B118 and the water phase channel B119 are connected to the liquid discharge end pipe 110; the bottom end of the longitudinal pipeline 1114 of the oil phase channel A116 and the top end of the longitudinal pipeline 1114 of the oil phase channel B118 are correspondingly arranged on the upper and lower sides of the constant volume hole 1110, and the lower end of the longitudinal pipeline of the water phase channel A117 and the top end of the longitudinal pipeline of the water phase channel B119 are correspondingly arranged on the upper and lower sides of the constant volume hole 1110. During operation, the oil phase liquid is injected into the corresponding constant volume hole 1110 of the constant volume disk through the oil phase channel A116 in the feed body, and is discharged along the oil phase channel B118 in the liquid collecting body; the water phase liquid is injected into the corresponding constant volume hole 1110 of the constant volume disk through the water phase channel A117 in the feed body, and is discharged along the water phase channel B119 in the liquid collecting body; in this process, the constant volume disk 114 is driven to rotate at a certain angle and a constant frequency, and the constant volume disk carries the oil phase droplets and the water phase droplets through the constant volume hole 1110 and is uniformly distributed in the water phase solution or the oil phase solution.

[0048] like Figure 1As shown, the water phase supply system includes a water phase storage tank 3 provided on the workbench and a water phase feed pump 8 provided at the bottom of the workbench, the bottom end of the water phase storage tank 3 is connected to the liquid inlet end of the water phase feed pump 8 through a lower liquid pipe 5, the liquid outlet end of the water phase feed pump 8 is connected to the liquid inlet end pipe 109 of the water phase channel A117 in the feed body through a feed pipe 6, and the water phase feed pump 8 quantitatively transports the water phase solution in the water phase storage tank to the water phase channel A117 in the feed body. The oil phase supply system includes an oil phase storage tank 2 provided on the workbench and an oil phase feed pump 7 provided at the bottom of the workbench, the bottom end of the oil phase storage tank 2 is connected to the liquid inlet end of the oil phase feed pump 7 through a lower liquid pipe 5, the liquid outlet end of the oil phase feed pump 7 is connected to the liquid inlet end pipe 109 of the oil phase channel A116 in the feed body through a feed pipe 6, and the oil phase feed pump 7 quantitatively transports the oil phase solution in the oil phase storage tank to the oil phase channel A116 in the feed body. The oil-water separation system includes an oil-water separator 15 arranged on the workbench and a water phase recycling pump 9 and an oil phase recycling pump 10 arranged at the bottom of the workbench. The bottom end of the oil-water separator 15 is connected to the water phase recovery tank 12 through a lower liquid pipe, and one side of the oil-water separator 15 is connected to the oil phase recovery tank 13 through an oil phase overflow pipe 14. The bottom end of the water phase recovery tank 12 is connected to the water phase recycling pump 9 and returns the water phase recovery liquid to the water phase storage tank 3 of the water phase supply system for storage. The bottom end of the oil phase recovery tank 13 is connected to the oil phase recycling pump 10 and returns the oil phase recovery liquid to the oil phase storage tank 2 of the oil phase supply system for storage. The finished product collection system includes a monodisperse droplet product tank 16 arranged on the workbench. The monodisperse droplet product tank 16 is connected to the water phase channel B119 through a droplet product delivery pipe 17. The water phase channel B119 in the aggregate body 113 collects highly monodisperse droplet products and delivers them to the monodisperse droplet product tank 16 through the droplet product delivery pipe 17 for storage.

[0049] In an optional embodiment, the thickness of the constant volume disk 114 is 1 mm, the diameter of the constant volume disk is 200 mm, the aperture of the constant volume hole 1110 is 0.2 mm, the diameter of the produced monodisperse droplets is about 200 μm, and the monodispersity is excellent. The constant volume disk includes a total of 1256 constant volume holes 1110, achieving a highly dispersed droplet production of 0.071 L / h.

[0050] In another optional embodiment, the thickness of the constant volume disk 114 is 3 mm, the diameter of the constant volume disk is 200 mm, the aperture diameter of the constant volume hole 1110 is 0.3 mm, the diameter of the produced monodisperse droplets is about 370 μm, and the monodispersity is excellent. The constant volume disk includes a total of 998 constant volume holes 1110, achieving a highly dispersed droplet output of 0.479 L / h.

[0051] Through the above embodiments, by selecting different constant volume disk diameters and constant volume hole diameters, mold planning production of highly dispersed droplets of different specifications can be achieved.

[0052] Reference Figure 7-11As shown, a method for large-scale production of highly monodisperse droplets comprises the following steps:

[0053] Step 1: setting the operating frequencies of the oil phase feed pump 7 and the water phase feed pump 8 in the oil phase supply system and the water phase supply system, and correspondingly setting the operating frequency of the driving motor in the driving mechanism;

[0054] Step 2: Start the oil phase supply system and the water phase supply system, and fill the oil phase and the water phase into the constant volume hole 1110 of the constant volume plate through the oil phase channel A116 and the water phase channel A117 in the feed body respectively;

[0055] Step 3: The oil phase supply system and the water phase supply system stop injecting liquid into the constant volume hole 1110 of the constant volume plate through the oil phase feed pump 7 and the water phase feed pump 8, and control the constant volume plate 114 to rotate at a certain angle along with the driving shaft through the driving motor, and the liquid droplets in the constant volume hole 1110 move along with the constant volume plate 114;

[0056] Step 4: the constant volume disk 114 rotates along with the driving shaft until the constant volume hole is aligned with the outlet end of the longitudinal pipe 1114 of the feed body again, and the constant volume disk 114 stops rotating;

[0057] Step 5: Start the oil phase supply system and the water phase supply system, and inject the oil phase and the water phase into the constant volume hole 1110 of the constant volume plate through the oil phase channel A116 and the water phase channel A117 in the feed body, respectively. The oil phase previously filled in the constant volume hole 1110 is blown out by the subsequently injected water phase, and the water phase previously filled in the constant volume hole 1110 is blown out by the subsequently injected oil phase;

[0058] Step 6: Repeat steps 2-5 cyclically to continuously produce monodisperse droplets, and collect and store the monodisperse droplet products through a finished product collection system.

[0059] The above are preferred embodiments of the present invention. It should be pointed out that, for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A device for large-scale production of highly monodisperse droplets, characterized in that: The large-scale production device (100) comprises: A monodisperse droplet generating device (1), the monodisperse droplet generating device (1) comprising a shell (108) and a cover plate (106) correspondingly arranged at the top of the shell; a drive shaft (104) is rotatably provided in the shell (108) and a fixed volume disk (114) is fixedly mounted thereon, and a plurality of fixed volume holes (1110) are provided on the disk surface of the fixed volume disk (114); a drive mechanism is provided corresponding to the drive shaft (104); a feed body (112) and a collection body (113) are provided in the shell (108) and are attached to the upper and lower sides of the fixed volume disk, the feed body (112) is provided with cross-arranged oil phase channels A (116) and water phase channels A (117), and the collection body (113) is provided with cross-arranged oil phase channels B (118) and water phase channels C (119) Channel B (119), the oil phase channel A (116) and the oil phase channel B (118) are correspondingly arranged on the upper and lower sides of the constant volume hole (1110), and the water phase channel A (117) and the water phase channel B (119) are correspondingly arranged on the upper and lower sides of the constant volume hole (1110); the oil phase channel A (116), the water phase channel A (117), the oil phase channel B (118), and the water phase channel B (119) all include an annular distribution pipe (1112), a main pipe (1111) arranged on the annular distribution pipe, and a horizontal distribution pipe (1113) radially arranged along the circumference of the annular distribution pipe and along the supply body (112) or the collecting body (113), and the horizontal distribution pipe (1113) is vertically provided with a plurality of longitudinal pipes (1114); an aqueous phase supply system, the aqueous phase supply system being connected to the aqueous phase channel A (117) and supplying an aqueous phase solution in a quantitative manner; An oil phase supply system, the oil phase supply system being connected to the oil phase channel A (116) and supplying the oil phase solution in a quantitative manner; An oil-water separation system, the oil-water separation system is connected to the oil phase channel B (118) and separates the oil phase and the water phase for recycling; A finished product collection system is connected to the water phase channel B (119) and collects highly monodisperse droplet products.

2. The device for large-scale production of highly monodisperse droplets according to claim 1, characterized in that: The constant volume hole (1110) is arranged along the radial direction of the constant volume disk (114) corresponding to the port of the longitudinal pipeline (1114).

3. The device for large-scale production of highly monodisperse droplets according to claim 1, characterized in that: A lower positioning pin (115) is provided at the bottom of the shell (108), and the collecting body (113) is clamped in the shell via the lower positioning pin (115); an upper positioning pin (107) is provided on the cover plate (106), and the lower end of the upper positioning pin (107) is fixedly pressed against the upper end of the supply body (112) via a pressing spring (111).

4. The device for large-scale production of highly monodisperse droplets according to claim 1, characterized in that: The driving mechanism comprises a reducer (102) and a driving motor (101) connected to a driving shaft (104) via a coupling (103).

5. The device for large-scale production of highly monodisperse droplets according to claim 1, characterized in that: The water phase supply system comprises a water phase storage tank (3) and a water phase feed pump (8), wherein the water phase feed pump (8) quantitatively transports the water phase solution in the water phase storage tank to the water phase channel A (117) in the feed body.

6. The device for large-scale production of highly monodisperse droplets according to claim 1, characterized in that: The oil phase supply system comprises an oil phase storage tank (2) and an oil phase feed pump (7), wherein the oil phase feed pump (7) quantitatively transports the oil phase solution in the oil phase storage tank to the oil phase channel A (116) in the feed body.

7. The device for large-scale production of highly monodisperse droplets according to claim 1, characterized in that: The oil-water separation system comprises an oil-water separator (15) and a water phase recovery tank (12) and an oil phase recovery tank (13) respectively connected to the oil-water separator. The water phase recovery tank (12) returns liquid to the water phase supply system via a water phase recovery pump (9), and the oil phase recovery tank (13) returns liquid to the oil phase supply system via an oil phase recovery pump (10).

8. The device for large-scale production of highly monodisperse droplets according to claim 1, characterized in that: The finished product collection system comprises a monodisperse droplet product tank (16) connected to the water phase channel B (119) via a droplet product delivery pipe (17).

9. A method for large-scale production of highly monodisperse droplets, characterized in that: Using the highly monodisperse droplet large-scale production device as described in any one of claims 1 to 8, the large-scale production method comprises the following steps: Step 1: setting the operating frequencies of the oil phase feed pump (7) and the water phase feed pump (8) in the oil phase supply system and the water phase supply system, and correspondingly setting the operating frequency of the drive motor in the drive mechanism; Step 2: Start the oil phase supply system and the water phase supply system, and fill the oil phase and water phase into the constant volume hole (1110) of the constant volume plate through the oil phase channel A (116) and the water phase channel A (117) in the feed body respectively; Step 3: the oil phase supply system and the water phase supply system stop injecting liquid into the constant volume hole (1110) of the constant volume disk via the oil phase feed pump (7) and the water phase feed pump (8), and control the constant volume disk (114) to rotate at a certain angle along with the drive shaft via the drive motor, so that the liquid droplets in the constant volume hole (1110) move along with the constant volume disk (114); Step 4: the constant volume disk (114) rotates along with the driving shaft until the constant volume hole is aligned with the outlet end of the longitudinal pipe (1114) of the feed body again, and the constant volume disk (114) stops rotating; Step 5: start the oil phase supply system and the water phase supply system, and respectively inject the oil phase and the water phase into the constant volume hole (1110) of the constant volume plate again through the oil phase channel A (116) and the water phase channel A (117) in the feed body, so that the oil phase previously filled in the constant volume hole (1110) is blown out by the subsequently injected water phase, and the water phase previously filled in the constant volume hole (1110) is blown out by the subsequently injected oil phase; Step 6: Repeat steps 2-5 cyclically to continuously produce monodisperse droplets, and collect and store the monodisperse droplet products through a finished product collection system.

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