Microecological bionic vernix caseosa with enhanced infant skin barrier function and preparation method thereof

Abstract

The present application relates to the field of skin care products, and specifically discloses a microecological bionic vernix with enhanced infant skin barrier function and a preparation method thereof. The microecological bionic vernix with enhanced infant skin barrier function comprises the following components: 10-60 parts of sunflower seed oil; 1-25 parts of phytosterol esters; 5-15 parts of jojoba seed oil; 0.05-10 parts of ceramide 3; 3-25 parts of plant wax esters; 0.1-6 parts of hydrogenated lecithin; 5-25 parts of thickeners; 0.1-5 parts of antioxidants; 1-12 parts of composite wax esters; 1.05-35 parts of water-soluble microecological skin care compositions; wherein the composite wax esters include polyglycerol-3 diisostearate, avocado tree fat, and beeswax; the water-soluble microecological skin care compositions include probiotics and prebiotics. The lipid components and water-soluble microecological skin care components in the present application can be stably fused and maintain the cheese-like appearance of bionic vernix, thereby exerting excellent barrier repair effects.

Description

Technical Field

[0001] The present application relates to the technical field of skin care products, and more specifically, to a microecological bionic vernix caseosa with enhanced infant skin barrier function and a preparation method thereof. Background Art

[0002] Vernix caseosa is the cheese-like sebum covering the surface of the fetal skin. It is a natural biological protective film that provides physical barrier protection, antibacterial and anti-infection, and pH buffering effects on the fetus. Vernix caseosa is composed of water (80%), lipids (10%), and proteins (10%). The core active ingredients are lipids, including triglycerides, sterols / cholesterol, squalene, ceramides, free fatty acids, phospholipids, etc. Based on the composition of vernix caseosa, multiple lipid components are compounded to form bionic vernix caseosa, which can be used in baby skin care to provide barrier protection.

[0003] There are significant differences between infant skin and adult skin. In addition to being less thick than that of adults, the skin microbiome is not mature enough, and the risk of resisting pathogens is poor. In addition, infants have many skin folds on their necks and armpits, and their skin functions are fragile. The skin contains a lot of water and has a high pH value, which is conducive to the growth and reproduction of pathogens. This is the main reason why infants are prone to skin problems. Therefore, adding some active ingredients that can promote the growth of beneficial bacteria and inhibit the proliferation of harmful bacteria to bionic vernix caseosa can help the skin maintain microecological balance and enhance skin immunity.

[0004] Regarding the above-mentioned related technologies, the inventors believe that most of the active ingredients in the current microecological skin care field are water-soluble raw materials, and the water-soluble raw materials have poor fusion with the lipid components of bionic vernix caseosa. The resulting bionic vernix caseosa products are difficult to maintain a stable cheese-like appearance and exert a stable barrier repair effect, and the overall performance still needs to be improved. Summary of the invention

[0005] In order to stably integrate the lipid components of bionic vernix caseosa with water-soluble microecological skin care components and exert a stable and excellent barrier repair effect, the present application provides a microecological bionic vernix caseosa with enhanced infant skin barrier function and a preparation method thereof.

[0006] In the first aspect, the present application provides a microecological bionic vernix caseosa with enhanced skin barrier function for infants, using the following technical solution:

[0007] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, comprising the following components in parts by weight:

[0008] 10-60 parts of sunflower seed oil;

[0009] 1-25 parts of phytosterol esters;

[0010] Jojoba seed oil 5-15 parts;

[0011] Ceramide 3 0.05-10 parts;

[0012] 3-25 parts of plant wax esters;

[0013] 0.1-6 parts of hydrogenated lecithin;

[0014] Thickener 5-25 parts;

[0015] 0.1-5 parts of antioxidant;

[0016] 1-12 parts of composite wax ester;

[0017] 1.05-35 parts of a water-soluble microecological skin care composition;

[0018] Among them, the complex wax ester includes polyglycerol-3 diisostearate, avocado butter, and beeswax; the water-soluble microecological skin care composition includes probiotics and prebiotics; and the mass ratio of the complex wax ester to the water-soluble microecological skin care composition is ≥1 / 3.

[0019] By adopting the above technical scheme, probiotics have the effect of upregulating the expression of antimicrobial peptides and regulating the skin microbial flora, thereby achieving the effect of soothing and strengthening the skin barrier; prebiotics have the effect of promoting the growth of beneficial bacteria and preventing the invasion of harmful bacteria, and also have the effect of activating Langerhans cells and improving skin immunity; the probiotics and prebiotics are combined as a water-soluble microecological skin care composition, which can be stably fused with the composite wax ester, and the composite wax ester composed of at least polyglycerol-3 diisostearate, avocado butter and beeswax plays a good bridge role between the water-soluble microecological skin care composition and the lipid component, thereby stably integrating the lipid component with the water-soluble microecological skin care component and maintaining the cheese-like appearance of the bionic vernix caseosa, so that the obtained microecological bionic vernix can exert excellent barrier repair effect during the application process. At the same time, the critical ratio between the complex wax ester and the water-soluble microecological skin care composition is 1:3. When the ratio is greater than this, the higher the amount of complex wax ester added, the more stable the product. When the ratio is lower than 1:3, a stable formula system cannot be formed. Therefore, the mass ratio of the complex wax ester to the water-soluble microecological skin care composition must be ≥1 / 3.

[0020] Preferably, the composite wax ester comprises the following components in parts by weight:

[0021] 1-35 parts of polyglyceryl-3 diisostearate;

[0022] 0-30 parts of sorbitan sesquioleate;

[0023] Avocado butter 5-20 parts;

[0024] 10-30 parts of beeswax.

[0025] By adopting the above technical scheme, the composite wax ester obtained in the above weight parts is relatively stable as a whole and can exert the best effect during the application process. It can achieve the best coordination effect with the water-soluble microecological skin care composition, thereby allowing the lipid component and the water-soluble microecological skin care component to form an excellent fusion stable state, and the obtained microecological bionic vernix caseosa also has the best efficacy.

[0026] Preferably, the composite wax ester comprises the following components in parts by weight:

[0027] 35 parts of polyglyceryl-3 diisostearate;

[0028] 28 parts of sorbitan sesquioleate;

[0029] Avocado butter 18 parts;

[0030] Beeswax 19 parts.

[0031] By adopting the above technical scheme and selecting the above mass ratio, the composite wax ester, water-soluble microecological skin care composition and other bionic vernix caseosa components can exert the best coordination effect, and the raw materials of each component are stably integrated with each other and exert excellent barrier repair effect.

[0032] Preferably, the water-soluble microecological skin care composition comprises the following components in parts by weight:

[0033] Probiotics 0.05-15 parts;

[0034] Prebiotics 1-20 servings.

[0035] By adopting the above technical scheme, the above-mentioned weight portions of probiotics and prebiotics can be combined to form a relatively stable water-soluble microecological skin care matrix, which is easier to cooperate with the complex wax esters during the application process, and then stably integrated with other bionic vernix caseosa components to form a microecological bionic vernix caseosa, which plays a role in maintaining the balance of skin microecology, enhancing skin immunity and strengthening the skin barrier.

[0036] Preferably, the water-soluble microecological skin care composition comprises the following components in parts by weight:

[0037] 5 servings of probiotics;

[0038] 10 servings of prebiotics.

[0039] By adopting the above technical scheme and selecting the above mass ratio, the water-soluble microecological skin care composition can exert excellent efficacy during the application process, which is conducive to obtaining microecological bionic vernix caseosa with better overall quality and enhanced infant skin barrier function.

[0040] Preferably, the prebiotic is β-1,3 glucan.

[0041] By adopting the above technical solution, the CAS number of β-1,3 glucan is 1439905-58-4, which is a repeating unit linear polymer connected by 7 β-1,3-glycosidic bonds and 2 α-1,3-glycosidic bonds, with a molecular weight of 2 to 2.5 million Daltons. As a ligand, β-glucan binds to the receptor Dectin-1 on the Langerhans cells (immune cells) in the skin, activates the skin immune system, and enhances the skin immune barrier. The three-dimensional helical structure formed by the β-1,3-glycosidic bonds in the β-glucan molecular structure is easier to bind to the receptor, thereby exerting stronger biological activity. Therefore, the proportion of β-1,3-glycosidic bonds determines the biological activity of the product. The proportion of β-1,3-glycosidic bonds in the β-1,3 glucan molecular structure is 75%, which is higher than other glucans on the market and has better skin care effects. At the same time, β-1,3 glucan is also a prebiotic that can promote the growth of probiotics, prevent the invasion of harmful bacteria, promote the expression of antimicrobial peptides, and maintain the balance of skin microecology.

[0042] Preferably, 5-15 parts of a regulating aid are added to the components of the microecological bionic vernix caseosa that has the function of strengthening the barrier function of infant skin. The regulating aid comprises the following components: salvianolic acid phospholipid complex, propolis extract and mesoporous silica, and the mass ratio is (1.1-1.3):(0.4-0.6):1.

[0043] By adopting the above technical scheme, the salvianolic acid phospholipid complex and propolis extract constitute spherical liposomes, and the water-soluble microecological skin care composition is encapsulated inside the spherical liposomes, and the formed dispersion is then filled into mesoporous silica, thereby greatly improving the binding between the lipid components of the bionic vernix caseosa and the water-soluble microecological skin care composition, forming a more stable state, and then being able to exert excellent therapeutic effects.

[0044] Preferably, the mass ratio of the salvianolic acid phospholipid complex, propolis extract and mesoporous silica is 1.3:0.5:1.

[0045] By adopting the above technical scheme, the components of the regulating auxiliary agent in the above mass ratio can exert the best use effect during the application process, especially in the application of microecological bionic vernix caseosa that has the function of strengthening the barrier function of infant skin, making the fusion between lipid components and water-soluble microecological skin care components more stable, and the barrier repair effect is the best.

[0046] In a second aspect, the present application provides a method for preparing a microecological bionic vernix caseosa with enhanced infant skin barrier function, using the following technical solution:

[0047] A method for preparing microecological bionic vernix caseosa with enhanced infant skin barrier function comprises the following steps:

[0048] (1) mixing the components in the water-soluble microecological skin care composition, dispersing them uniformly and heating them; mixing the components in the composite wax ester, heating them until they are completely dissolved; then adding the water-soluble microecological skin care composition to the composite wax ester under stirring conditions, homogenizing and cooling them to obtain a premix A; and at the same time, mixing sunflower seed oil, phytosterol ester, jojoba seed oil, ceramide 3, plant wax ester, hydrogenated lecithin, a thickener and an antioxidant, heating them until they are completely dissolved to obtain a premix B;

[0049] (2) Premix B is stirred, and premix A is added during the heat preservation and stirring process, and the mixture is filled after being evenly mixed. After cooling and molding, a microecological bionic vernix caseosa product having a function of strengthening the barrier function of infant skin is obtained.

[0050] By adopting the above technical solution, after heating the composite wax ester and the water-soluble microecological skin care composition respectively, the water-soluble microecological skin care composition is added to the composite wax ester and sheared and homogenized at high speed, so that the water-soluble microecological skin care composition is fully integrated into the composite wax ester; and then premix A is added to the subsequent premix B, so that the lipid component and the water-soluble microecological skin care component are stably integrated together and the cheese-like appearance of the bionic vernix is ​​maintained, and a product of excellent quality is obtained. At the same time, the production method is simple to operate and has excellent overall application.

[0051] Preferably, a method for preparing a microecological bionic vernix caseosa having a function of strengthening the skin barrier of infants comprises the following steps:

[0052] (1) mixing the components in the water-soluble microecological skin care composition, dispersing them uniformly, and heating them to 80-85° C.; mixing the components in the composite wax ester, and heating them to 80-85° C. until they are completely dissolved, then adding the water-soluble microecological skin care composition to the composite wax ester at a stirring speed of 50-60 rpm, homogenizing, and cooling to obtain a premix A; at the same time, mixing sunflower seed oil, phytosterol ester, jojoba seed oil, ceramide 3, plant wax ester, hydrogenated lecithin, a thickener, and an antioxidant, and heating them to 80-85° C. until they are completely dissolved to obtain a premix B;

[0053] (2) Premix B is stirred at a stirring speed of 30-40 rpm, cooled to 70-75° C., and premix A is added during the heat preservation and stirring process. After the mixture is evenly mixed, the mixture is stirred and cooled. When the temperature drops to 60-65° C., the mixture is canned. After cooling and molding, a microecological bionic vernix caseosa product with enhanced infant skin barrier function is obtained.

[0054] By adopting the above technical scheme, the composite wax ester and the water-soluble microecological skin care composition are heated to the above temperature respectively, and the aqueous phase is added to the composite wax ester and sheared and homogenized at high speed, which is conducive to the fusion of the two; when adding premix A to premix B, the stirring speed is controlled to 30-40rmp, which can avoid the generation of bubbles due to excessively fast rotation speed during the mixing process of the lipid component and the water-soluble microecological skin care component, affecting the appearance of the finished product; and the filling temperature is 60-65°C, which can prevent the filling temperature from being too low, causing the material body to form a paste and affecting the uniformity of the finished product; the above operations are conducive to obtaining a microecological bionic vernix caseosa product with excellent quality and enhanced infant skin barrier function.

[0055] In summary, this application has the following beneficial effects:

[0056] 1. The combination of probiotics and prebiotics as a water-soluble microecological skin care composition can be stably fused with the composite wax ester, thereby greatly improving the fusion with other lipid components of bionic vernix caseosa, and forming a more stable mixed state, which is conducive to making the bionic vernix caseosa finished product exert a more excellent barrier repair effect;

[0057] 2. Add regulating aids, use salvianolic acid phospholipid complex and propolis extract to liposome-encapsulate the water-soluble microecological skin care composition, and then fill the formed dispersion into mesoporous silica to make the fusion between the lipid component and the water-soluble microecological skin care component more stable and the product quality better. DETAILED DESCRIPTION

[0058] The present application is further described in detail below in conjunction with embodiments.

[0059] The raw materials used in the examples of this application are commercially available except for the following special instructions:

[0060]

[0061]

[0062] Preparation Example

[0063] Preparation Example 1

[0064] A composite wax ester, the components and their corresponding weight parts are shown in Table 1, and is prepared by the following method:

[0065] (1) preparing raw materials including polyglyceryl-3 diisostearate, sorbitan sesquioleate, shea butter and beeswax according to a ratio;

[0066] (2) The raw materials in step (1) are mixed, heated at 85° C. until completely dissolved, stirred evenly at a stirring speed of 40 rpm, and cooled to room temperature of 25° C. to obtain a composite wax ester.

[0067] Preparation Example 2-4

[0068] A composite wax ester, which is different from Preparation Example 1 in that its components and their corresponding weight portions are shown in Table 1.

[0069] Table 1 Components and their weight fractions in Preparation Examples 1-4

[0070] Components Preparation Example 1 Preparation Example 2 Preparation Example 3 Preparation Example 4 Polyglyceryl-3 diisostearate 35 35 1 18 Sorbitan sesquioleate 28 30 0 15 Avocado Butter 18 20 5 12.5 beeswax 19 30 10 20

[0071] Example

[0072] Example 1

[0073] A microecological bionic vernix caseosa with enhanced infant skin barrier function, the components and their corresponding weight parts are shown in Table 2, and the product is prepared by the following method:

[0074] (1) The components in the water-soluble microecological skin care composition are mixed, dispersed evenly, and heated to 80-85° C. (85° C. is selected in this embodiment); the components in the composite wax ester are mixed, heated to 80-85° C. until completely dissolved (85° C. is selected in this embodiment), and then the water-soluble microecological skin care composition is added to the composite wax ester at a stirring speed of 50-60 rpm (55 rpm is selected in this embodiment), homogenized and then cooled to obtain a premix A; at the same time, sunflower seed oil, phytosterol ester, jojoba seed oil, ceramide 3, plant wax ester, hydrogenated lecithin, a thickener and an antioxidant are mixed, and heated to 80-85° C. until completely dissolved (85° C. is selected in this embodiment) to obtain a premix B;

[0075] (2) Premix B is stirred at a stirring speed of 30-40 rpm (35 rpm is selected in this embodiment), and the temperature is reduced to 70-75° C. (70° C. is selected in this embodiment), and premix A is added during the heat preservation and stirring process. After mixing evenly, stirring and cooling are continued. When the temperature drops to 60-65° C., it is canned (60° C. is selected in this embodiment), and after cooling and molding, a microecological bionic vernix caseosa product with enhanced infant skin barrier function is obtained.

[0076] Note: The thickener in the above steps is beeswax; the antioxidant is mixed tocopherol; the prebiotic is β-1,3 glucan; the water-soluble microecological skin care composition is composed of probiotics and prebiotics, and their corresponding weight parts are shown in Table 2; the composite wax ester is selected from Preparation Example 1.

[0077] Embodiment 2-5

[0078] A microecological bionic vernix caseosa with enhanced infant skin barrier function, which is different from Example 1 in that its components and their corresponding weight portions are shown in Table 2.

[0079] Table 2 Components and their weight fractions in Examples 1-5

[0080]

[0081]

[0082] Example 6

[0083] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which is different from Example 1 in that the composite wax ester is selected from Preparation Example 2.

[0084] Example 7

[0085] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which is different from Example 1 in that the composite wax ester is selected from Preparation Example 3.

[0086] Example 8

[0087] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which is different from Example 1 in that the composite wax ester is selected from Preparation Example 4.

[0088] Example 9

[0089] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 1 in that 10 parts of a regulating aid are further added, and the regulating aid comprises the following components: salvianolic acid phospholipid complex, propolis extract and mesoporous silica, and the mass ratio is 1.3:0.5:1.

[0090] Example 10

[0091] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 1 in that 5 parts of a regulating aid are also added, and the regulating aid comprises the following components: salvianolic acid phospholipid complex, propolis extract and mesoporous silica, and the mass ratio is 1.3:0.5:1.

[0092] Embodiment 11

[0093] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 1 in that 15 parts of a regulating aid are further added, and the regulating aid comprises the following components: salvianolic acid phospholipid complex, propolis extract and mesoporous silica, and the mass ratio is 1.3:0.5:1.

[0094] Example 12

[0095] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 1 in that 10 parts of a regulating aid are further added, and the regulating aid comprises the following components: salvianolic acid phospholipid complex, propolis extract and mesoporous silica, and the mass ratio is 1.2:0.5:1.

[0096] Example 13

[0097] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 1 in that 10 parts of a regulating aid are further added, and the regulating aid comprises the following components: salvianolic acid phospholipid complex, propolis extract and mesoporous silica, and the mass ratio is 1.1:0.4:1.

[0098] Embodiment 14

[0099] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 1 in that 10 parts of a regulating aid are further added, and the regulating aid comprises the following components: salvianolic acid phospholipid complex, propolis extract and mesoporous silica, and the mass ratio is 1.3:0.6:1.

[0100] Embodiment 15

[0101] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 9 in that the regulating auxiliary agent is a salvianolic acid phospholipid complex.

[0102] Example 16

[0103] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 9 in that the regulating auxiliary agent is propolis extract.

[0104] Embodiment 17

[0105] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 9 in that mesoporous silica is used as a regulating auxiliary agent.

[0106] Embodiment 18

[0107] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 9 in that the regulating auxiliary agent comprises the following components: salvianolic acid phospholipid complex and propolis extract, and the mass ratio is 1.3:0.5.

[0108] Embodiment 19

[0109] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 9 in that the regulating auxiliary agent comprises the following components: salvianolic acid phospholipid complex and mesoporous silica, and the mass ratio is 1.3:1.

[0110] Embodiment 20

[0111] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 9 in that the regulating auxiliary agent comprises the following components: propolis extract and mesoporous silica, and the mass ratio is 0.5:1.

[0112] Comparative Example

[0113] Comparative Example 1

[0114] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 1 in that the weight proportion of the composite wax ester is 4.8 parts.

[0115] Comparative Example 2

[0116] A microecological bionic vernix caseosa with enhanced skin barrier function for infants, which differs from Example 1 in that the weight portion of the composite wax ester is 2 parts.

[0117] Comparative Example 3

[0118] A microecological bionic vernix caseosa with enhanced infant skin barrier function, which differs from Example 1 in that the mass of the composite wax ester in the raw materials is replaced by other component raw materials in the corresponding mass ratio.

[0119] Performance test samples: The microecological bionic vernix caseosa with enhanced infant skin barrier function obtained in Examples 1-20 is used as Example test sample 1-20, and the microecological bionic vernix caseosa with enhanced infant skin barrier function obtained in Comparative Examples 1-3 is used as Comparative Example control sample 1-3.

[0120] Test method:

[0121] (1) Stability test:

[0122] Test 1: Test samples 1-20 and control samples 1-3 were canned in transparent glass jars and placed in high temperature, low temperature, and alternating hot and cold environments, and stability was investigated after a period of time;

[0123] High temperature environment: 48°C, placed in a biochemical incubator, placed for 3 months, returned to room temperature, and observed the appearance;

[0124] Low temperature environment: -18℃, placed in the freezer for 3 months, then returned to room temperature and observed the appearance;

[0125] Alternating hot and cold: cold environment -18℃ (24 hours) - room temperature environment 25℃ (24 hours) - hot environment 48℃ (24 hours), after 2 weeks of circulation, return to room temperature and observe the appearance.

[0126] Test 2: After the prepared microecological bionic fetal fat in test samples 1-20 and control samples 1-3 were placed for 48 hours, the dispersed phase particle size was observed using an Olympus upright high-power microscope BX53M, and the particle size statistical analysis was performed using the software OLYCIA p3 to obtain the average particle size value and standard deviation.

[0127] (2) Application efficacy test: Test samples 1-20 and control samples 1-3 were tested as follows: TEWL test: 30 subjects who felt that their facial skin was dry and flaky were selected. The product was applied to the face twice a day, once in the morning and once in the evening, with a coin-sized amount applied each time, for 4 consecutive weeks. The change of transepidermal water loss (TEWL) was tested using the instrument VAPOMETER (Delfin). Before each measurement, the subject cleaned the facial skin with clean water and dried it with a non-chip absorbent paper towel. The subject sat quietly for 20 minutes in a room that met the test environment conditions, remained relaxed, and avoided touching the facial skin.

[0128] TEWL change rate = (TEWL after 4 weeks of use - TEWL before use) / TEWL before use

[0129] β-defensin 2 (hBD-2) test: hBD-2 is mainly expressed in epithelial tissue and is synthesized and secreted by keratinocytes. It is a cationic small molecule antimicrobial peptide that protects the skin from invasion by foreign pathogens. It has a broad-spectrum and highly effective antibacterial effect and plays an important role in maintaining the healthy microecological balance of the skin.

[0130] A 3D epidermal model was constructed and incubated for 2 hours at 37°C, 5% CO2, and in a humid environment. The model was then topically treated with the formula sample. After 48 hours of treatment, the expression of hBD-2 was analyzed by immunohistochemical staining, microscopic photography, and IPP software for image data quantification.

[0131] hBD-2 expression level change rate = (hBD-2 expression level after 48 hours of treatment - hBD-2 expression level after 48 hours of untreated) / hBD-2 expression level after 48 hours of untreated.

[0132] Table 3 Stability test results of test samples 1-20 and control samples 1-3

[0133]

[0134]

[0135] Table 4 Application efficacy test results of test samples 1-20 and control samples 1-3

[0136]

[0137]

[0138] It can be seen from the combination of Examples 1-5 and Comparative Examples 1-2 and Tables 3 and 4 that the addition ratio between the composite wax ester and the water-soluble microecological skin care composition can seriously affect the stability of the finished product. Wherein, in Examples 1-5, as the ratio of the composite wax ester decreases, the average particle size and the standard deviation of the particle size of the finished product increase, the uniformity of the particle size distribution decreases, and the product stability is relatively reduced. Secondly, the critical mass ratio between the composite wax ester and the water-soluble microecological skin care composition is 1:3. When it is higher than this ratio, a stable formula system can be formed. In Example 5, the mass ratio between the composite wax ester and the water-soluble microecological skin care composition is 1:3, and its average particle size and standard deviation are both shown as the maximum compared to Examples 1-4, but it has passed the 3-month appearance stability inspection; when it is lower than this ratio, a stable formula system cannot be formed, and demulsification and oiling phenomenon occur. In Comparative Examples 1 and 2, the mass ratios between the composite wax ester and the water-soluble microecological skin care composition are 1:3.125 and 1:7.5, respectively, and oiling phenomenon occurs, and the formula is unstable. In addition, in the application efficacy test results of test samples 1-20 and control samples 1-3, the higher the proportion of the water-soluble microecological composition, the higher the hBD-2 expression level; while the improvement of TEWL had no significant correlation with the proportion of the water-soluble microecological skin care composition.

[0139] Combining Examples 1-5 and Comparative Example 3 and Tables 3 and 4, it can be seen that the combination of probiotics and prebiotics as a water-soluble microecological skin care composition can be stably fused with the composite wax ester, and the fusion between the lipid components of other bionic vernix fat is greatly improved, and a more stable mixed state is formed, so that the obtained microecological bionic vernix fat shows excellent stability in high temperature, low temperature, and hot and cold alternating environments, and shows excellent barrier repair effect in product applications. When the composite wax ester is not used at all in the formula system, the finished product completely collapses and does not take shape.

[0140] Combining Example 1 with Examples 6-8 and Tables 3 and 4, it can be seen that the selection of each component raw material in the composite wax ester within a specific range can make the obtained finished product have excellent stability, and the skin care effect brought by the product application is relatively stable. Among them, the components of the composite wax ester in Example 1 are the optimal ratio, and the stability is better than that of Examples 6-8.

[0141] Combining Example 1 and Examples 9-20 and Table 3 and Table 4, it can be seen that the addition of a regulating aid composed of a specific ratio of salvianolic acid phospholipid complex, propolis extract and mesoporous silica can greatly improve the stability of the microecological bionic fetal fat. In Examples 12, 13, and 14, the regulating aid is 10 parts, but it is not the optimal ratio. The overall effect is slightly worse than that of Example 9. Combining Examples 10 and 11, it can be obtained that under the optimal ratio of regulating aid, Example 9 adds 10 parts of regulating aid, and the effect is the best; at the same time, the salvianolic acid phospholipid complex and the propolis extract in the regulating aid form spherical liposomes, which increases the skin permeability of the water-soluble microecological skin care composition. The liposomes are embedded in the mesoporous silica, which increases the stability of the formula, and the application efficacy improvement brought about is also better than that of Example 1. In Examples 15-20, any one or a combination of salvianolic acid phospholipid complex, propolis extract and mesoporous silica as regulating aids does not increase product stability. However, in Example 19, due to the compounding of salvianolic acid phospholipid complex and propolis extract, liposomes can be formed to promote the transdermal penetration of water-soluble components, and the hBD-2 expression level change rate is better than that in Example 1. The TEWL change rate and hBD-2 expression level change rate of other examples are not much different from those of Example 1.

[0142] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. Microecological bionic vernix caseosa with enhanced skin barrier function for infants, characterized in that: It is composed of the following components in parts by weight: 10-60 parts of sunflower seed oil; 1-25 parts of phytosterol esters; Jojoba seed oil 5-15 parts; Ceramide 3 0.05-10 parts; 3-25 parts of plant wax esters; 0.1-6 parts of hydrogenated lecithin; Thickener 5-25 parts; 0.1-5 parts of antioxidant; 1-12 parts of composite wax ester; 1.05-35 parts of a water-soluble microecological skin care composition; 5-15 parts of regulating agent; Wherein, the composite wax ester is composed of polyglycerol-3 diisostearate, avocado tree butter, and beeswax; the water-soluble microecological skin care composition is composed of probiotics and prebiotics; and the mass ratio of the composite wax ester to the water-soluble microecological skin care composition is ≥1 / 3; The composite wax ester is composed of the following components in parts by weight: 35 parts of polyglyceryl-3 diisostearate; 28 parts of sorbitan sesquioleate; Avocado butter 18 parts; Beeswax 19 parts; The water-soluble microecological skin care composition is composed of the following components in parts by weight: 5 servings of probiotics; Prebiotics 10 servings; The prebiotic is β-1,3 glucan; The regulating auxiliary agent is composed of the following components: salvianolic acid phospholipid complex, propolis extract and mesoporous silica, and the mass ratio is (1.1-1.3): (0.4-0.6):

1.

2. The microecological bionic vernix caseosa with enhanced skin barrier function for infants according to claim 1, characterized in that: The mass ratio of the salvianolic acid phospholipid complex, propolis extract and mesoporous silica is 1.3: 0.5:

1.

3. The method for preparing the microecological bionic vernix caseosa with enhanced infant skin barrier function according to claim 1, characterized in that: The following steps are involved: (1) The components in the water-soluble microecological skin care composition are mixed, dispersed evenly and heated; the components in the composite wax ester are mixed and heated until completely dissolved; then the water-soluble microecological skin care composition is added to the composite wax ester under stirring conditions, homogenized and then cooled to obtain a premix A; at the same time, sunflower seed oil, phytosterol ester, jojoba seed oil, ceramide 3, plant wax ester, hydrogenated lecithin, thickener and antioxidant are mixed and heated until completely dissolved to obtain a premix B; (2) Premix B is stirred, and premix A and a regulating aid are added during the heat preservation and stirring process. After mixing evenly, the mixture is filled, and after cooling and molding, a microecological bionic vernix caseosa product having a function of strengthening the barrier function of infant skin is obtained.

4. The method for preparing the microecological bionic vernix caseosa with enhanced infant skin barrier function according to claim 3, characterized in that: The specific steps include: (1) The components in the water-soluble microecological skin care composition are mixed, dispersed evenly, and heated to 80-85°C; the components in the composite wax ester are mixed, heated to 80-85°C until completely dissolved, and then the water-soluble microecological skin care composition is added to the composite wax ester at a stirring speed of 50-60 rpm, homogenized and then cooled to obtain a premix A; at the same time, sunflower seed oil, phytosterol ester, jojoba seed oil, ceramide 3, plant wax ester, hydrogenated lecithin, thickener and antioxidant are mixed, and heated to 80-85°C until completely dissolved to obtain a premix B; (2) Premix B is stirred at a stirring speed of 30-40 rpm, cooled to 70-75° C., and premix A and regulating aids are added during the heat preservation and stirring process. After mixing evenly, stirring and cooling are continued. When the temperature drops to 60-65° C., it is canned. After cooling and molding, a microecological bionic vernix caseosa product with enhanced infant skin barrier function is obtained.

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