Multi-channel blood viscosity measurement device

Abstract

The present invention relates to a multi-channel blood viscosity measuring device, and more particularly, to a multi-channel blood viscosity measuring device including a blood sample pre-treatment part which scans and shakes a blood collection tube and then separates a blood collection tube cap, a blood sample transfer part for moving the blood collection tube placed by the blood sample pre-treatment part, a blood viscosity measuring part which is installed with a blood viscosity measuring kit for measuring the viscosity of the injected blood sample and includes one or more channels, and a blood sample post-treatment part which installs the blood viscosity measuring kit on the blood viscosity measuring part, sucks the blood sample of the blood collection tube transferred by the blood sample transfer part, and injects the same into the installed blood viscosity measuring kit.

Description

TECHNICAL FIELD

[0001] The present application relates to a multi-channel blood viscosity measuring device, and more particularly, to a multi-channel blood viscosity measuring device capable of automatically and simultaneously measuring the viscosity of one or more blood samples, so that the viscosity of the blood samples can be measured uniformly, thereby improving accuracy and reducing working time. BACKGROUND

[0002] The viscosity of blood is a physical value indicating flow resistance generated by the flow of blood in blood vessels, and can be specifically classified into whole blood viscosity and plasma viscosity. An abnormally increased blood viscosity increases shear stress acting on the inner wall of blood vessels and flow resistance, thereby significantly increasing the risk of acute cardiovascular disease and microvascular disease. In addition, plasma viscosity is not only used to diagnose inflammation conditions in the body, but is also one of the main causes of increased whole blood viscosity.

[0003] Whole blood viscosity shows flow characteristics in which the viscosity constantly changes according to the systolic and diastolic periods of the heart, because the viscosity decreases when blood flows quickly (when the shear rate is high) due to the mutual interaction of red blood cells and plasma proteins present in whole blood, and, conversely, the viscosity increases when blood flows slowly (when the shear rate is low). A fluid that exhibits such flow characteristics is called a non-Newtonian fluid, and in order to correctly understand the non-Newtonian flow characteristics of blood, it is necessary to accurately measure the whole blood viscosity with respect to the overall shear rate (for example: 1 ~ 1000 s^-1).

[0004] Recently, a blood viscosity measuring device can measure the viscosity of blood or the blood cell aggregation rate, etc. by passing blood obtained from the human body through a flow restrictor tube, measuring the flow characteristics of blood in the flow restrictor tube.

[0005] As a related art, Korean Patent No. 20-0331884 (Device for simultaneously measuring blood viscosity and blood cell aggregation rate) is disclosed.

[0006] However, since the device operator needs to manually inject blood through a syringe to measure the viscosity of blood, it is difficult to supply blood at a constant pressure and a constant flow rate, and there is a problem in that it is difficult to measure the viscosity of blood under the same conditions. In addition, since it is a manual operation, there is a problem in that the working time is long.

[0007] In addition, since it is a manual operation, infection problems caused by blood also frequently occur.

[0008] To solve this problem, an automated blood viscosity measuring device is being developed, but when the viscosity measurement of one blood sample is completed, the viscosity measurement of the next blood sample is performed, and thus there is a problem in that a lot of working time is required.

[0009] Furthermore, when a large number of blood samples are measured, if the blood sample is a blood sample in a later order, as time passes, the viscosity of the blood is measured in a state in which red blood cells and the like have already settled, and thus there is a problem in that the accuracy of the viscosity measurement is reduced. SUMMARY

[0010] Problem to be Solved by the Invention

[0011] To solve the above problem, the present invention aims to provide a multi-channel blood viscosity measuring device capable of automatically and simultaneously measuring the viscosity of one or more blood samples, such that the viscosity measurement of the blood samples can be performed uniformly, thereby improving the accuracy and reducing the working time.

[0012] Solution to Problem

[0013] To solve the above technical problem, a multi-channel blood viscosity measuring device according to an embodiment of the present invention can include a blood sample pre-processing unit that scans and shakes a blood collection tube and then separates a blood collection tube cap, a blood sample transfer unit for moving the blood collection tube placed by the blood sample pre-processing unit, a blood viscosity measuring unit installed with a blood viscosity measuring kit for measuring the viscosity of an injected blood sample and including one or more channels, and a blood sample post-processing unit that installs the blood viscosity measuring kit on the blood viscosity measuring unit, sucks the blood sample of the blood collection tube transferred by the blood sample transfer unit, and injects the blood sample into the installed blood viscosity measuring kit.

[0014] The blood sample pre-processing unit can include a pre-processing clamp unit capable of clamping and rotating the blood collection tube, and a pre-processing position adjusting unit for adjusting the position of the pre-processing clamp unit.

[0015] Further, the pre-processing clamp unit can include a pre-processing clamp capable of clamping or placing the blood collection tube, a first rotating unit capable of rotating the pre-processing clamp about a z-axis, and a second rotating unit capable of rotating the pre-processing clamp about an x-axis or a y-axis.

[0016] Further, the pre-treatment position adjusting part can include one or more of a pre-treatment up-down adjusting part to adjust the position of the pre-treatment clamp part in the up-down direction, a pre-treatment left-right adjusting part to adjust the position of the pre-treatment clamp part in the left-right direction, and a pre-treatment front-rear adjusting part to adjust the position of the pre-treatment clamp part in the front-rear direction.

[0017] Further, the blood sample transferring part can include a transferring clamp part to place the blood collection tube through the blood sample pre-treatment part, and a transferring unit connected to the transferring clamp part to transfer the placed blood collection tube.

[0018] Further, the blood viscosity measuring part can include a kit mounting part to mount the blood viscosity measuring kit, a viscosity measuring unit to measure the viscosity of the blood sample injected into the blood viscosity measuring kit, and a kit inserting unit to insert or pull out the kit mounting part into or from the viscosity measuring unit.

[0019] Further, the blood sample post-treatment part can include a kit clamp part to clamp or place the blood viscosity measuring kit, a pipette part to which a pipette tip is mounted to suck the blood sample of the transferred blood collection tube and inject it into the mounted blood viscosity measuring kit, and a post-treatment position adjusting part to adjust the positions of the kit clamp part and the pipette part.

[0020] Further, the post-treatment position adjusting part can include one or more of a post-treatment up-down adjusting part to adjust the positions of the kit clamp part and the pipette part in the up-down direction, a post-treatment left-right adjusting part to adjust the positions of the kit clamp part and the pipette part in the left-right direction, and a post-treatment front-rear adjusting part to adjust the positions of the kit clamp part and the pipette part in the front-rear direction.

[0021] Further, the post-treatment up-down adjusting part can include a kit up-down adjusting part connected to the kit clamp part to adjust the position of the kit clamp part in the up-down direction, and a comprehensive up-down adjusting part connected to the kit up-down adjusting part and the pipette part to adjust the positions of the kit clamp part and the pipette part in the up-down direction.

[0022] Further, it can include a control part to control the operations of the blood sample pre-treatment part, the blood sample transferring part, the blood viscosity measuring part, and the blood sample post-treatment part, and a monitoring part to monitor the viscosity measurement result measured by the blood viscosity measuring part.

[0023] In addition, it may include a blood sample mounting section, which can mount more than one blood collection tube.

[0024] In addition, it may include a blood viscosity measurement kit for storing the blood viscosity measurement kit before use.

[0025] In addition, it may include a pipette tip storage section for storing pipette tips before use.

[0026] In addition, it may include a waste disposal unit for containing a blood viscosity measurement kit for which the blood sample viscosity measurement has been completed in the blood viscosity measurement unit.

[0027] Invention Effects

[0028] The multi-channel blood viscosity measuring device according to embodiments of the present invention can automatically measure the viscosity of blood samples contained in blood collection tubes without additional operation by equipment operators, and can process waste reagent kits after measuring blood viscosity, thus it can be highly efficient when measuring a large number of blood samples.

[0029] Furthermore, by uniformly measuring the viscosity of blood samples, the accuracy of viscosity measurements for each blood sample can be improved.

[0030] Furthermore, since viscosity can be measured on more than one blood sample at the same time, the working time can be further reduced. Attached Figure Description

[0031] Figure 1 This is a perspective view showing a multi-channel blood viscosity measuring device according to an embodiment of the present invention.

[0032] Figure 2 This is a perspective view showing the partial disassembly of the multi-channel blood viscosity measuring device according to an embodiment of the present invention.

[0033] Figure 3 It is shown Figure 2 A three-dimensional view of the blood sample pretreatment section.

[0034] Figure 4 It shows that Figure 3 An enlarged stereoscopic view of the pre-processed clamp.

[0035] Figure 5 (a) and (b) are schematic diagrams illustrating the operation of the pretreatment clamp of the multi-channel blood viscosity measuring device according to an embodiment of the present invention, in the state of scanning and shaking the blood collection tube.

[0036] Figure 6 It shows that Figure 3A magnified side view of the pre-processed upper and lower adjustment section.

[0037] Figure 7 It is shown Figure 2 A rotating stereoscopic view of the blood sample transfer unit.

[0038] Figure 8 (a) and (b) are schematic diagrams illustrating the process of placing blood collection tubes on the blood sample transfer section of a multi-channel blood viscosity measuring device according to an embodiment of the present invention and transferring them.

[0039] Figure 9 It is shown Figure 2 A rotating stereoscopic view of the blood viscosity measurement unit.

[0040] Figure 10 (a) and (b) are schematic diagrams showing the operation of the blood viscosity measurement kit after it is installed on the blood viscosity measurement unit of the multi-channel blood viscosity measurement device according to an embodiment of the present invention.

[0041] Figure 11 It is shown Figure 2 A three-dimensional view of the blood sample post-processing unit.

[0042] Figure 12 It shows that Figure 11 A magnified side view of the post-processing up and down adjustment section.

[0043] Figure 13 (a) to (c) are schematic diagrams showing the operation state of the post-processing up and down adjustment section of the multi-channel blood viscosity measuring device according to an embodiment of the present invention.

[0044] Figure 14 This is a projected perspective view of a blood viscosity measurement kit for a multi-channel blood viscosity measurement device according to an embodiment of the present invention.

[0045] Figure 15 It shows that Figure 14 A three-dimensional diagram showing the breakdown of a blood viscosity measurement kit.

[0046] Figure 16 (a) and (b) are shown to be formed in Figure 15 Top-view and bottom-view perspectives of the microchannels in the main body of the reagent kit.

[0047] Figure 17 It is shown Figure 15 A three-dimensional view of the microchannel cap.

[0048] Figure 18 It is shown Figure 14 A front cross-sectional view of the blood viscosity measurement kit.

[0049] Figure 19 (a) and (b) of FIG. 1 are perspective and sectional views showing an injection cap of the blood viscosity measuring device according to an embodiment of the present application. Figure 15

[0050] Figure 20 (a) to (d) of FIG. 2 are schematic views showing shapes in which a blood injection hole of the injection cap of the blood viscosity measuring device according to an embodiment of the present application is formed in other forms. Figure 19 DETAILED DESCRIPTION

[0051] The present application can provide a multi-channel blood viscosity measuring device, and the multi-channel blood viscosity measuring device according to an embodiment of the present application includes a blood sample pre-processing part which scans and shakes a blood collection tube and then separates a blood collection tube cap, a blood sample transfer part for moving the blood collection tube placed by the blood sample pre-processing part, a blood viscosity measuring part in which a blood viscosity measuring kit is installed and which includes one or more channels for measuring the viscosity of an injected blood sample, and a blood sample post-processing part which installs the blood viscosity measuring kit on the blood viscosity measuring part, sucks the blood sample of the blood collection tube transferred by the blood sample transfer part, and injects the same into the installed blood viscosity measuring kit.

[0052] BEST MODE FOR CARRYING OUT THE INVENTION

[0053] The following description of the present application with reference to the accompanying drawings is not limited to specific embodiments and various changes and various embodiments can be made. In addition, the following description should be understood as including all changes, equivalents and substitutes within the scope of the idea and technical scope of the present application.

[0054] In the following description, the terms first, second, etc. are used as terms for describing various structural elements and are not limited to their own meanings and are used only for the purpose of distinguishing one structural element from other structural elements.

[0055] The same reference numerals are used throughout the specification to denote the same structural elements.

[0056] The singular expression used in the present application includes the plural expression unless it is explicitly stated otherwise. In addition, the terms "include" or "have" and the like used in the following description should be interpreted as specifying the presence of stated features, numbers, steps, actions, structural elements, components or combinations of these, and do not preclude the presence or addition of one or more other features, numbers, steps, actions, structural elements, components or combinations thereof.

[0057] Hereinafter, embodiments of the present application will be described in detail with reference to the accompanying drawings. Figures 1 to 20

[0058] ​​​Figure 1 is a perspective view showing a multi-channel blood viscosity measuring device according to an embodiment of the present application; Figure 2 is a perspective view showing a multi-channel blood viscosity measuring device according to an embodiment of the present application, partially disassembled;

[0059] Figure 3 is a perspective view showing Figure 2 a blood sample pre-processing section; Figure 4 is a perspective view showing Figure 3 a pre-processing clamp section of Figure 5 (a) and (b) of FIG. 16 are operation schematic views showing a state in which a pre-processing clamp section of a multi-channel blood viscosity measuring device according to an embodiment of the present application is operated to scan and shake a blood collection tube; Figure 6 is a perspective view showing Figure 3 a pre-processing up-and-down adjustment section of Figure 7 is a perspective view showing Figure 2 a blood sample transfer section of Figure 8 (a) and (b) of FIG. 18 are schematic views showing a process in which a blood collection tube is placed on a blood sample transfer section of a multi-channel blood viscosity measuring device according to an embodiment of the present application and is transferred; Figure 9 is a perspective view showing Figure 2 a blood viscosity measuring section of

[0060] Figure 10 (a) and (b) of FIG. 22 are operation schematic views showing a state in which a blood viscosity measuring kit is installed on a blood viscosity measuring section of a multi-channel blood viscosity measuring device according to an embodiment of the present application and is operated;

[0061] Figure 11 is a perspective view showing Figure 2 a blood sample post-processing section of Figure 12 is a perspective view showing Figure 11 a post-processing up-and-down adjustment section of Figure 13 (a) to (c) of FIG. 26 are operation schematic views showing an operation state of a post-processing up-and-down adjustment section of a multi-channel blood viscosity measuring device according to an embodiment of the present application.

[0062] An object of the present application is to provide a multi-channel blood viscosity measuring device in which a channel of a blood viscosity measuring section 7 for measuring viscosity of a blood sample is formed as a multi-channel, and viscosity of a blood sample contained in a blood collection tube is automatically measured without an additional operation of an equipment operator, thereby enabling uniform measurement of viscosity of a blood sample and shortening a time when viscosity of a large number of blood samples is measured.

[0063] Referring to Figure 1 and Figure 2The multi-channel blood viscosity measuring device can include a housing 1, a blood sample installation portion 2, a blood viscosity measuring cartridge 3, a pipette tip storage portion 4, a blood sample pre-treatment portion 5, a blood sample transfer portion 6, a blood viscosity measuring portion 7, a blood sample post-treatment portion 8, a waste treatment portion 9, a control portion (not shown), and a monitoring portion 10.

[0064] First, the housing 1 can be provided with the structure of the multi-channel blood viscosity measuring device, and the provided structure can be covered, thereby including a support housing and a cover housing.

[0065] The upper surface of the support housing is provided with the blood sample installation portion 2, the blood viscosity measuring cartridge 3, the pipette tip storage portion 4, the blood sample pre-treatment portion 5, the blood sample transfer portion 6, the blood viscosity measuring portion 7, the blood sample post-treatment portion 8, etc. of the multi-channel blood viscosity measuring device, and can be covered by the cover housing, but is not limited thereto.

[0066] In addition, the cover housing is formed with a door, so that the inside of the housing 1 can be opened when the user needs to install or remove more than one blood collection tube B from the blood sample installation portion 2.

[0067] The blood sample installation portion 2 can be formed in the shape of a test tube rack so as to vertically insert the blood collection tube B. In this case, it includes a plurality of blood collection tube installation holes, so that a plurality of blood collection tubes B can be installed. Such a blood sample installation portion 2 can be formed on the front side of the upper surface of the support housing, but is not limited thereto.

[0068] The blood viscosity measuring cartridge 3 can store a blood viscosity measuring reagent kit 30 before use, and is preferably formed to store more than one blood viscosity measuring reagent kit 30, and since the upper surface is open, the blood sample post-treatment portion 8 can easily grip the blood viscosity measuring reagent kit 30, but is not limited thereto. Such a blood viscosity measuring cartridge 3 can be formed on the front center side of the upper surface of the support housing, but is not limited thereto.

[0069] The pipette tip storage portion 4 can store a pipette tip before use, and includes a plurality of pipette tip holes into which the pipette tip can be inserted, so that more than one pipette tip can be stored. Such a pipette tip storage portion 4 can be formed on the other side of the front surface of the upper surface of the support housing, but is not limited thereto.

[0070] The blood sample pre-treatment portion 5 can detect more than one blood collection tube B installed on the blood sample installation portion 2, and grip the blood collection tube B, scan and shake the blood collection tube B, and then place the blood collection tube B on the blood sample transfer portion 6 and separate the blood collection tube cap.

[0071] The blood sample pre-processing part 5 can be formed at one side of the upper surface of the support housing, but is not limited thereto.

[0072] Referring to Figure 3 The blood sample pre-processing part 5 can include a blood collection tube detection part 50, a blood sample reading part 51, a pre-processing clamp part 52, and a pre-processing position adjustment part 53.

[0073] The blood collection tube detection part 50 is provided at one side of the pre-processing clamp part 52 and detects one or more blood collection tubes B mounted on the blood sample mounting part 2, thereby obtaining blood collection tube mounting information, i.e., position and quantity information of the blood collection tube B.

[0074] More specifically, the blood collection tube detection part 50 can photograph one or more blood collection tubes B mounted on the blood sample mounting part 2 by laser scanning or image photographing to confirm an image, and obtain blood collection tube mounting information, i.e., position and quantity information of the blood collection tube B by analyzing the image.

[0075] Thereby, the blood sample pre-processing part 5 can automatically pick up or place the blood collection tube B according to the blood collection tube mounting information, and can implement viscosity measurement of blood samples of all the blood collection tubes B.

[0076] The blood sample reading part 51 can scan the blood collection tube B to acquire blood sample information, i.e., can obtain blood sample information of a blood sample contained in the blood collection tube B by scanning a barcode attached to the blood collection tube B.

[0077] Thereby, it can be confirmed what blood sample is being measured for viscosity, and the measured viscosity measurement result can be automatically stored as a result of the blood sample information.

[0078] Further, the blood sample reading part 51 can transmit the obtained blood sample information to the monitoring part 10 so that a user can confirm.

[0079] The pre-processing clamp part 52 can clamp and rotate the blood collection tube B mounted on the blood sample mounting part 2, and can separate the blood collection tube cap from the blood collection tube B by adjusting the position thereof through the pre-processing position adjustment part 53.

[0080] Further, the pre-processing clamp part 52 can insert the blood collection tube cap into the blood collection tube B into which a blood sample is sucked and transferred by the blood sample transfer part 6, and then mounted on the blood sample mounting part 2, according to the position adjusted by the pre-processing position adjustment part. In this case, the mounted position can be the position where the blood collection tube B is mounted.

[0081] Referring to Figure 4 and Figure 5The pre-treatment clamp 52 can include a pre-treatment clamp 520, a first rotating part 521, and a second rotating part 522.

[0082] The pre-treatment clamp 520 is formed in a symmetrical pair, and can hold or place the blood collection tube B. In this case, the pre-treatment clamp 520 can include a holding groove 5200 and a latching part 5201.

[0083] The holding groove 5200 is formed in the inner surface of the lower end of the pre-treatment clamp 520, and can accommodate the upper portion of the blood collection tube B, and can accommodate the blood collection tube cap located in the upper portion. Accordingly, it is preferable to be formed in a shape corresponding to the cap of the blood collection tube B, but is not limited thereto.

[0084] The latching part 5201 is formed in the lower end of the holding groove 5200, and can thereby latch the blood collection tube cap.

[0085] Thus, the blood collection tube B is placed and fixed on the blood sample transfer part 6, and in a state in which the blood collection tube cap of the blood collection tube B is held by the pre-treatment clamp 520, as the pre-treatment clamp 52 moves upward, the blood collection tube cap can be separated from the blood collection tube B.

[0086] The first rotating part 521 can rotate the pre-treatment clamp 520 about the z-axis. Such a first rotating part 521 can be formed to be connected to the upper side of the pre-treatment clamp 520 and rotatable by 360° about the z-axis.

[0087] Thus, as shown in (a) of FIG. 6, the blood collection tube B held with the pre-treatment clamp 520 is rotated by 360° about the z-axis and scanned in the blood sample reading part 51, and thus the bar code of the blood collection tube B can be easily scanned. Figure 5 As shown in (b) of FIG. 6, the second rotating part 522 can rotate the pre-treatment clamp 520 about the y-axis, but is not limited thereto, and can also rotate about the x-axis.

[0088] Figure 5 Such a second rotating part 522 is connected to the upper side of the first rotating part 521, and can rotate the pre-treatment clamp 520 about the y-axis.

[0089] As time passes, red blood cells in the blood sample can sink, and if the blood viscosity is measured in this state, a problem of reduced measurement accuracy can occur.

[0090] Thus, by shaking the blood collection tube B through the second rotating part 522, the plasma and red blood cells of the blood sample are mixed, and thus the accuracy of the blood viscosity measurement can be improved.

[0091] Thus, by shaking the blood collection tube B through the second rotating part 522, the plasma and red blood cells of the blood sample are mixed, and thus the accuracy of the blood viscosity measurement can be improved.

[0092] ​Thus, the first rotating part 521 can be connected to the upper side of the pretreatment tongs 520, and the second rotating part 522 can be connected to the upper side of the first rotating part 521, but the structure is not limited thereto, and various changes can be made to the structure, such as connecting the second rotating part 522 to the upper side of the pretreatment tongs 520 and then connecting the first rotating part 521 to the upper side of the second rotating part 522.

[0093] The pretreatment position adjusting part 53 is provided on the support housing 1 and is connected to the pretreatment tongs 52, so that the position of the pretreatment tongs 52 can be adjusted.

[0094] To this end, the pretreatment position adjusting part 53 can include one or more of a pretreatment up-down adjusting part 530, a pretreatment left-right adjusting part 531, and a pretreatment front-rear adjusting part 532. At this time, it is preferable to adjust the position of the pretreatment tongs 52 by adjusting the positions in the up-down, left-right, and front-rear directions, respectively, but the structure is not limited thereto.

[0095] The pretreatment up-down adjusting part 530 is capable of adjusting the position of the pretreatment tongs 52 in the up-down direction and is connected to the pretreatment tongs 52, so that the pretreatment tongs 52 can be moved in the up-down direction.

[0096] Referring to Figure 6 , the pretreatment up-down adjusting part 530 can include a first up-down connecting member 5300 and a first up-down adjusting unit 5301.

[0097] The first up-down connecting member 5300 is formed in a shape, can be connected to the rear side of the pretreatment tongs 52, but the shape is not limited thereto and can be formed in various shapes.

[0098] In addition, the first up-down connecting member 5300 is connected to the first up-down adjusting unit 5301 and moves up and down, so that the pretreatment tongs 52 can move up and down. At this time, it is preferable that the first up-down adjusting unit 5301 be connected to the rear side of the lower end, but the structure is not limited thereto.

[0099] The first up-down adjusting unit 5301 is connected to the first up-down connecting member 5300 and can move the first up-down connecting member 5300 up and down.

[0100] To this end, the first up-down adjusting unit 5301 can be configured as a cylinder provided perpendicular to the ground, but the structure is not limited thereto and various actuators and devices capable of moving the pretreatment tongs 52 up and down can be applied.

[0101] The pretreatment left-right adjusting part 531 is capable of adjusting the position of the pretreatment tongs 52 in the left-right direction, is connected to the pretreatment up-down adjusting part 530 and moves in the left-right direction, so that the pretreatment tongs 52 can move left and right.

[0102] To this end, the pre-treatment left-right adjustment part 531 can include a first left-right connecting member 5310 and a first left-right adjustment unit 5311.

[0103] The first left-right connecting member 5310 can be connected with the rear side of the pre-treatment up-down adjustment part 530, and more specifically, can be connected with the rear side of the first up-down adjustment unit 5301. However, it is not limited thereto, and the first up-down adjustment unit 5301 and the first left-right adjustment unit 5311 can be directly connected without the first left-right connecting member 5310.

[0104] The first left-right adjustment unit 5311 is connected with the rear side of the first left-right connecting member 5310, and moves the first left-right connecting member 5310 left and right, and can move the pre-treatment jaw part 52 left and right.

[0105] Such a first left-right adjustment unit 5311 can be configured as a linear actuator provided to have a length in the left-right direction, but is not limited thereto, and various devices such as various forms of actuators, rails, etc. can be applied.

[0106] The pre-treatment front-rear adjustment part 532 can adjust the position of the pre-treatment jaw part 52 in the front-rear direction, and is connected with the pre-treatment left-right adjustment part 531 and moves in the front-rear direction, and thus can move the pre-treatment jaw part 52 forward and backward.

[0107] To this end, the pre-treatment front-rear adjustment part 532 can include a first front-rear connecting member 5320 and a first front-rear adjustment unit 5321.

[0108] The first front-rear connecting member 5320 can be connected with one side of the pre-treatment left-right adjustment part 531, and more specifically, can be connected with one side of the first left-right adjustment unit 5311. However, it is not limited thereto, and various forms of connection such as direct connection of the first left-right adjustment unit 5311 and the first front-rear adjustment unit 5321 without the first front-rear connecting member 5320, etc. can be possible.

[0109] The first front-rear adjustment unit 5321 is provided on the support housing, and is connected with the lower side of the first front-rear connecting member 5320 to move the first front-rear connecting member 5320 forward and backward, and thus can move the pre-treatment jaw part 52 forward and backward.

[0110] Such a first front-rear adjustment unit 5321 can be configured as a linear actuator provided to have a length in the front-rear direction, but is not limited thereto, and various devices such as various forms of actuators, rails, etc. can be applied.

[0111] As described above, the pre-treatment up-and-down adjustment section 530, the pre-treatment left-and-right adjustment section 531, and the pre-treatment front-and-back adjustment section 532 are connected to the pre-treatment clamp section 52, so that the positions in the up-and-down, left-and-right, and front-and-back directions can be adjusted, but are not limited thereto, and the order of connection can be variously changed.

[0112] The operation of the blood sample pre-treatment section 5 will be described in more detail in sequence.

[0113] First, the blood collection tube detection section 50 acquires blood collection tube installation information by detecting the blood collection tube B installed in the blood sample installation section 2. The pre-treatment position adjustment section 53 adjusts the position of the pre-treatment clamp section 52 according to the acquired blood collection tube installation information, and the pre-treatment clamp section 52 can grip the blood collection tube B.

[0114] Next, the pre-treatment clamp section 52 is moved by the pre-treatment position adjustment section 53, so that the blood collection tube B is scanned in the blood sample reading section 51. At this time, the pre-treatment clamp section 52 can rotate and scan the blood collection tube B by the operation of the first rotating section 521.

[0115] Next, the blood collection tube B can be shaken by the operation of the second rotating section 522 of the pre-treatment clamp section 52.

[0116] Next, the pre-treatment clamp section 52 is moved by the pre-treatment position adjustment section 53, and the blood collection tube B is placed on the blood sample transfer section 6. When the blood collection tube B is fixed to the blood sample transfer section 6, the pre-treatment clamp section 52 is raised by the pre-treatment position adjustment section 53, so that the blood collection tube cap can be separated from the blood collection tube B.

[0117] Next, when the blood collection tube B in which blood is sucked is moved by the blood sample transfer section 6, the pre-treatment clamp section 52 is lowered by the pre-treatment position adjustment section 53, so that the blood collection tube cap can be inserted into the blood collection tube B. When the blood collection tube cap is inserted, the fixing of the blood collection tube B by the transfer clamp section 60 can be released.

[0118] Next, the pre-treatment clamp section 52 is moved by the pre-treatment position adjustment section 53, so that the blood collection tube B can be re-installed at the original position of the blood sample installation section 2.

[0119] The blood sample pre-treatment section 5 repeats the above process, so that the viscosity measurement of a plurality of blood samples can be implemented.

[0120] Referring to Figure 7 and Figure 8 , the blood sample transfer section 6 moves the blood collection tube B placed by the blood sample pre-treatment section 5 in the left-and-right direction, and can include a transfer clamp section 60 and a transfer unit 61.

[0121] The transfer tongs 60 can place the blood collection tube B through the blood sample pre-treatment section 5 and fix the placed blood collection tube B. To this end, the transfer tongs 60 can include a placing part 600 and a transfer tong 601.

[0122] The placing part 600 can be formed with a tube-shaped placing groove capable of placing the blood collection tube B.

[0123] The transfer tong 601 is provided at one side of the placing part 600 to be capable of fixing the blood collection tube B placed in the tube-shaped placing groove. In addition, when the transfer tongs 60 are moved from the other side to the one side, the transfer tong 601 is opened, thereby releasing the fixing of the blood collection tube B.

[0124] Such transfer tongs 60 are connected with the transfer unit 61 and can be moved in the left-right direction (both sides direction) by the transfer unit 61.

[0125] The transfer unit 61 is connected with the transfer tongs 60 to be capable of transferring the placed blood collection tube B, specifically, when the blood collection tube B is placed on the transfer tongs 60 and the blood collection cap is separated, the transfer tongs 60 are transferred from the one side to the other side, and when the blood sample of the blood collection tube B is sucked, the transfer tongs 60 can be transferred from the other side to the one side. The above process can be automatically repeated.

[0126] Such transfer unit 61 can be configured as a linear actuator provided to have a length in the left-right direction, but is not limited thereto, and various devices such as various forms of actuators, rails, etc. can also be applied.

[0127] Such blood sample transfer section 6 can be formed between the blood sample pre-treatment section 5 and the blood sample post-treatment section 8 on the upper surface of the support housing, but is not limited thereto.

[0128] Referring to Figure 9 , the blood viscosity measurement section 7 measures the viscosity of the blood sample using the blood viscosity measurement kit 30, and can be formed as one or more channels 70. It is preferable to be formed as a plurality of channels 70 so that the viscosity of a plurality of blood samples can be measured at the same time. Although the blood viscosity measurement section 7 is shown as 8 channels in Figure 9 , it is not limited thereto.

[0129] The channel 70 is installed with the blood viscosity measurement kit 30, so that the viscosity of the injected blood sample can be measured.

[0130] Such channel 70 can include a kit mounting part 700, a kit guide part 701, a viscosity measurement unit 702, and a kit insertion unit 703.

[0131] The kit mounting part 700 can be mounted with the blood viscosity measurement kit 30 and moved along the kit guide part 701 by the kit insertion unit 703, so as to be inserted into the inside of the viscosity measurement unit 702. In the state that the blood viscosity measurement kit 30 is mounted, when the kit mounting part 700 is inserted into the viscosity measurement unit 702, the blood sample can be injected from the blood sample post-processing part 8 into the blood viscosity measurement kit 30.

[0132] In addition, the kit mounting part 700 includes a kit mounting groove so as to be able to mount the blood viscosity measurement kit 30, and the other side can be connected with the kit insertion unit 703.

[0133] The kit guide part 701 can include a guide mounted with the kit mounting part 700 and movable. In addition, it can be provided that one side is connected with the viscosity measurement unit 702, so that the kit mounting part 700 moving along the guide can be inserted into the viscosity measurement unit 702.

[0134] The viscosity measurement unit 702 is provided to be connected with one side of the kit guide part 701, so that the kit mounting part 700 mounted with the blood viscosity measurement kit 30 is inserted into the inside, and the viscosity of the blood sample injected into the blood viscosity measurement kit 30 can be measured.

[0135] In addition, the viscosity measurement unit 702 can include a viscosity measurement housing and an optical sensor (not shown).

[0136] The viscosity measurement housing can be formed in a box shape, and the other side can be open so as to be able to insert or pull out the blood viscosity measurement kit 30, but is not limited thereto.

[0137] In addition, the viscosity measurement housing can be formed in a way that the other side of the upper surface is partially open, so as to be able to inject the blood sample in the state that the blood viscosity measurement kit 30 is inserted into the inside, but is not limited thereto.

[0138] The optical sensor is used to measure the height of the blood sample injected into the blood viscosity measurement kit 30 over time, so as to be able to measure the viscosity of the blood sample. The viscosity measurement result measured as described above can be transmitted to the monitoring part 10.

[0139] Referring to Figure 10 , the kit insertion unit 703 is connected with the other side of the kit mounting part 700, and when the blood viscosity measurement kit 30 is inserted into the kit mounting part 700, it can be inserted into the viscosity measurement unit 702.

[0140] Further, when the viscosity measurement of the viscosity measurement unit 702 is completed, the kit insertion unit 703 can pull out the kit mounting member 700 from the viscosity measurement unit 702 so that the blood viscosity measurement kit 30 can be processed.

[0141] To this end, the kit insertion unit 703 is configured as a cylinder and is horizontally disposed on the kit mounting member so that the kit mounting member 700 can be inserted into or pulled out from the viscosity measurement unit 702 by a pull-out or introduction operation, but is not limited thereto and various actuators, devices (rails, conveyors, etc.) capable of movement can also be applied.

[0142] The blood sample post-processing unit 8 mounts the blood viscosity measurement kit 30 on the blood viscosity measurement unit 7 and aspirates the blood sample of the blood collection tube B transferred through the blood sample transfer unit 6 by mounting the pipette tip and can inject it into the mounted blood viscosity measurement kit 30. Further, the used pipette tip and the blood viscosity measurement kit 30 can be processed in the waste processing unit 9.

[0143] Referring to Figure 11 , the blood sample post-processing unit 8 can include a kit clamp unit 80, a pipette unit 81, and a post-processing position adjustment unit 82.

[0144] The kit clamp unit 80 can adjust the position by the post-processing position adjustment unit 82 so that the blood viscosity measurement kit 30 can be clamped or placed.

[0145] The pipette unit 81 mounts the pipette tip and can aspirate the blood sample of the transferred blood collection tube B and inject it into the mounted blood viscosity measurement kit 30. The position thereof is adjusted by the post-processing position adjustment unit 82 so that the pipette tip in the pipette tip storage unit 4 can be mounted and the blood sample can be aspirated and injected. Further, the used pipette tip can be processed in the waste processing unit 9.

[0146] The post-processing position adjustment unit 82 is disposed on the support housing and is connected with the kit clamp unit 80 and the pipette unit 81 so that the positions of the kit clamp unit 80 and the pipette unit 81 can be adjusted.

[0147] To this end, the post-processing position adjustment unit 82 can include one or more of a post-processing up-down adjustment unit 820, a post-processing left-right adjustment unit 821, and a post-processing front-rear adjustment unit 822. At this time, it is preferable to adjust the positions of the kit clamp unit 80 and the pipette unit 81 by adjusting the positions including the up-down, left-right, and front-rear directions, respectively, but is not limited thereto.

[0148] The post-treatment up-and-down adjustment part 820 can adjust the positions of the reagent kit clamp part 80 and the pipette part 81 in the up-and-down direction.

[0149] At this time, if the positions of the reagent kit clamp part 80 and the pipette part 81 in the up-and-down direction are adjusted to be the same, collision can occur, and thus, the positions of the reagent kit clamp part 80 and the pipette part 81 in the up-and-down direction can be adjusted separately.

[0150] Accordingly, the post-treatment up-and-down adjustment part 820 can include a reagent kit up-and-down adjustment part 8200 and a comprehensive up-and-down adjustment part 8201.

[0151] The reagent kit up-and-down adjustment part 8200 is connected to the reagent kit clamp part 80 and can move the reagent kit clamp part 80 in the up-and-down direction.

[0152] Referring to Figure 12 and Figure 13 , the reagent kit up-and-down adjustment part 8200 can include a reagent kit up-and-down connection part 8200a and a reagent kit up-and-down adjustment unit 8200b.

[0153] The reagent kit up-and-down connection part 8200a is formed in the shape of , and can be connected to the upper side of the reagent kit clamp part 80, but the shape is not limited thereto and can be formed in various shapes.

[0154] In addition, the reagent kit up-and-down connection part 8200a is connected to the reagent kit up-and-down adjustment unit 8200b and moves up and down, so that the reagent kit clamp part 80 can move up and down. At this time, preferably, the reagent kit up-and-down adjustment unit 8200b is connected to the lower end rear side, but is not limited thereto.

[0155] The reagent kit up-and-down adjustment unit 8200b is connected to the reagent kit up-and-down connection part 8200a and can move the reagent kit up-and-down connection part 8200a up and down.

[0156] To this end, the reagent kit up-and-down adjustment unit 8200b can be configured as a pneumatic cylinder disposed perpendicular to the ground, but is not limited thereto and various actuators, devices capable of moving the reagent kit clamp part 80 up and down can be applied.

[0157] The comprehensive up-and-down adjustment part 8201 can include a comprehensive up-and-down connection part 8201a and a comprehensive up-and-down adjustment unit 8201b.

[0158] The comprehensive up-and-down connection part 8201a is formed in the shape of , and can be connected to the rear side of the reagent kit up-and-down adjustment part 8200 and the pipette part 81, but the shape is not limited thereto and can be formed in various shapes.

[0159] Further, the integrated upper-and-lower connecting member 8201a is connected to the integrated upper-and-lower adjustment unit 8201b and moves up and down, so that the reagent kit clamp portion 80 and the pipette portion 81 can move up and down together. At this time, it is preferable that the integrated upper-and-lower adjustment unit 8201b be connected to the rear side of the lower end, but is not limited thereto.

[0160] The integrated upper-and-lower adjustment unit 8201b is connected to the integrated upper-and-lower connecting member 8201a, so as to be movable up and down.

[0161] To this end, the integrated upper-and-lower adjustment unit 8201b can be configured as a pneumatic cylinder provided to be perpendicular to the ground, but is not limited thereto, and various actuators, devices capable of moving the reagent kit clamp portion 80 and the pipette portion 81 up and down can be applied.

[0162] Further, the post-processing left-and-right adjustment portion 821 can be connected to the rear side of the integrated upper-and-lower adjustment unit 8201b, but is not limited thereto.

[0163] The post-processing left-and-right adjustment portion 821 is capable of adjusting the positions of the reagent kit clamp portion 80 and the pipette portion 81 in the left-and-right direction, and is connected to the post-processing upper-and-lower adjustment portion 820 and moves in the left-and-right direction, so that the reagent kit clamp portion 80 and the pipette portion 81 can move left and right.

[0164] To this end, the post-processing left-and-right adjustment portion 821 can include a second left-and-right connecting member 8210 and a second left-and-right adjustment unit 8211.

[0165] The second left-and-right connecting member 8210 can be connected to the rear side of the post-processing upper-and-lower adjustment portion 820, and more specifically, can be connected to the rear side of the integrated upper-and-lower adjustment unit 8201b. However, it is not limited thereto, and can be connected in various positions without the second left-and-right connecting member 8210 and the like by directly connecting the integrated upper-and-lower adjustment unit 8201b and the second left-and-right adjustment unit 8211.

[0166] The second left-and-right adjustment unit 8211 is connected to the rear side of the second left-and-right connecting member 8210 and moves left and right, so that the reagent kit clamp portion 80 and the pipette portion 81 can move left and right.

[0167] Such a second left-and-right adjustment unit 8211 can be configured as a linear actuator in the same manner as the first left-and-right adjustment unit 5311, but is not limited thereto.

[0168] The post-processing front-and-rear adjustment portion 822 is capable of adjusting the positions of the reagent kit clamp portion 80 and the pipette portion 81 in the front-and-rear direction, and is connected to the post-processing left-and-right adjustment portion 821 and moves in the front-and-rear direction, so that the reagent kit clamp portion 80 and the pipette portion 81 can move forward and backward.

[0169] Therefore, the post-processing pre- and post-treatment adjustment unit 822 may include a second pre- and post-treatment connecting member 8220 and a second pre- and post-treatment adjustment unit 8221. This post-processing pre- and post-treatment adjustment unit 822 may be a device that is substantially the same as the pre-processing pre- and post-treatment adjustment unit 532, except that its position and orientation, as well as the connection structure, are different.

[0170] The second front-to-back connecting part 8220 can be connected to one side of the post-processing left-to-right adjustment part 821.

[0171] The second front-to-back adjustment unit 8221 is disposed on the support housing and is connected to the lower side of the second front-to-back connecting part 8220 to move back and forth, thereby enabling the reagent kit forceps 80 and the pipette part 81 to move back and forth.

[0172] In this case, the second front-to-back adjustment unit 8221 can be configured as a linear actuator in the same way as the first front-to-back adjustment unit 5321, but is not limited thereto.

[0173] In addition, the post-processing up-down adjustment section 820, the post-processing left-right adjustment section 821, and the post-processing front-back adjustment section 822 of the post-processing position adjustment section 82 are connected to the reagent kit clamp section 80 and the pipette section 81, so that the position in the up-down, left-right, and front-back directions can be adjusted, but the connection order can be changed in various ways.

[0174] The operation of this blood sample post-processing unit 8 will be described in more detail in turn.

[0175] First, the positions of the reagent kit clamp 80 and the pipette section 81 are adjusted by the post-processing position adjustment unit 82, and the reagent kit clamp 80 is moved downward by the reagent kit up-down adjustment unit 8200, thereby clamping the blood viscosity measurement reagent kit 30. After clamping, the blood viscosity measurement reagent kit 30 can be mounted on the blood viscosity measurement unit 7 by moving it by the post-processing position adjustment unit 82.

[0176] Next, the reagent kit forceps 80 and the pipette section 81 are moved by the post-processing position adjustment section 82, so that the pipette tip can be installed on the pipette section 81.

[0177] Next, the reagent kit clamp 80 and the pipette section 81 are moved by the post-processing position adjustment section 82, so that the pipette section 81 draws in the blood sample transferred to the blood collection tube B on the other side by the blood sample transfer section 6, and is moved by the post-processing position adjustment section 82, so that the blood sample can be injected into the blood viscosity measurement reagent kit 30 installed on the blood viscosity measurement section 7.

[0178] Next, the used pipette tip can be moved via the post-processing position adjustment unit 82 and processed in the waste disposal unit 9.

[0179] The blood sample post-processing section 8 repeats the above process, so that the viscosity measurement of a plurality of blood samples can be performed.

[0180] Further, the blood sample post-processing section 8 can also process the blood viscosity measurement kit 30, which has completed the measurement in the blood viscosity measurement section 7, in the waste processing section 9 in the middle of repeating the above process.

[0181] Since the blood sample pre-processing section 5, the blood sample transfer section 6, and the blood sample post-processing section 8 repeat the respective operations as described above, the viscosity measurement of a plurality of blood samples can be performed automatically and uniformly.

[0182] The waste processing section 9 is formed in the support housing, so that the used blood viscosity measurement kit 30 and the pipette tip can be accommodated for subsequent processing.

[0183] The control section (not shown) can control the operation of the multi-channel blood viscosity measurement device including the blood sample pre-processing section 5, the blood sample transfer section 6, and the blood viscosity measurement section 7.

[0184] For example, the control section can operate the blood sample pre-processing section 5 according to the blood collection tube installation information received from the blood collection tube detection section 50, and can determine the number of repetitions of each structure in the multi-channel blood viscosity measurement device according to the quantity information of the blood collection tube installation information, and control the operation accordingly.

[0185] In addition, the control section can receive information from each structure and transmit it to the monitoring section 10, and receive control setting information from the monitoring section 10, and each structure can control the operation accordingly.

[0186] The monitoring section 10 receives and outputs the blood collection tube installation information detected by the blood collection tube detection section 50, the blood sample information obtained by scanning the blood collection tube B by the blood sample reading section 51, the viscosity measurement result measured by the channel 70 of the blood viscosity measurement section 7, and the like from the control section, so that the user can be monitored.

[0187] In addition, the monitoring section 10 can receive and provide various information of the multi-channel blood viscosity measurement device, such as operation information and state information of each structure, and the like.

[0188] In addition, the monitoring section 10 can receive control setting information from the user and control each structure through the control section.

[0189] The following will use Figures 14 to 20 The blood viscosity measurement kit 30 used in the multi-channel blood viscosity measurement device according to the embodiment of the present application as described above will be described in detail.

[0190] Figure 14is a perspective view showing a blood viscosity measurement kit of a multi-channel blood viscosity measurement device according to an embodiment of the present application; Figure 15 is an exploded perspective view showing the blood viscosity measurement kit of Figure 14 disassembled; Figure 16 (a) and (b) of FIG. 10 are bottom perspective view and bottom view showing a micro channel formed in the kit body of Figure 15 ; Figure 17 is a perspective view showing a micro channel cover of Figure 15 ; Figure 18 is a front sectional view showing the blood viscosity measurement kit of Figure 14 ; Figure 19 (a) and (b) of FIG. 12 are perspective view and sectional view showing an injection cover of Figure 15 ; Figure 20 (a) to (d) of FIG. 13 are schematic views showing shapes in which a blood injection hole of the injection cover of Figure 19 is formed in other forms.

[0191] Referring to Figure 14 and Figure 15 , the blood viscosity measurement kit 30 according to an embodiment of the present application can include a kit body 300, two-side blood tubes 301, a micro channel 302, a micro channel cover 303, and an injection cover 304.

[0192] The kit body 300 is formed of a transparent material, and can be provided with the two-side blood tubes 301 and the micro channel 302 so that blood can flow. As described above, since the inside is formed of a structure that is transparently visible, it is possible to confirm the movement of blood in the two-side blood tubes 301 and the micro channel 302 in real time.

[0193] By this, it is possible to identify an error in blood viscosity measurement.

[0194] Further, preferably, the kit body 300 is formed in a size of about 60 mm in width x 70 mm in height or less, thereby being formed in a small size. By this, it is possible to reduce the amount of blood required when measuring blood viscosity, and when blood is injected, it is necessary to preheat the kit to 36.5°C in order to create an environment similar to that of the human body, and the kit of the above-described small size can quickly achieve preheating.

[0195] Further, the kit body 300 can include a first coupling groove 3000 and a second coupling groove 3001 so that the micro channel cover 303 can be coupled and fixed.

[0196] The first coupling groove 3000 is formed in the bottom surface of the kit body 300 in a manner of following the outer circumferential surface of the kit body, so that the first coupling protrusion 3031a can be inserted.

[0197] The second coupling groove 3001 is formed adjacent to the first coupling groove 3000 and a plurality of the above-described second coupling groove 3001 is formed in a "zigzag" shape from the front side to the rear side in the length direction, so that the second coupling protrusion 3031b can be inserted. That is, the second coupling groove 3001 can be formed between the first curved portion 3020 and the first curved portion 3020, between the second curved portion 3021 and the second curved portion 3021.

[0198] In addition, the second coupling groove 3001 can be formed in a manner that the upper portion surface thereof is inclined downward from the outside to the inside.

[0199] The both-side blood tubes 301 are symmetrically formed on both sides of the kit main body 300 and the upper side is formed in an open manner, so that blood can be injected. Among them, the both-side blood tubes 301 can be formed to have a length perpendicular to the upper portion surface of the kit main body 300 when viewed in the front, but are not limited thereto and can also be formed to be inclined downward from both sides of the upper end of the kit main body 300 in a manner toward the center.

[0200] In addition, the both-side blood tubes 301 are formed in a manner that the lower portion surface thereof is open, so that the open lower side can be sealed by the micro channel cover 303. Thereby, blood injected into the both-side blood tubes 301 can flow into the micro channel 302 without flowing out to the outside.

[0201] In addition, the both-side blood tubes 301 can include a cover insertion groove 3010, in the upper end of which the injection cover 304 can be inserted.

[0202] The cover insertion groove 3010 is formed in the upper end of the both-side blood tubes 301 in a manner larger than the diameter of the both-side blood tubes 301 and is formed in a manner corresponding to the size of the injection cover 304, so that the injection cover 304 can be inserted.

[0203] Also, the lower end portion of the both-side blood tubes 301 can be connected by the micro channel 302.

[0204] Thereby, when blood is injected into one of the both-side blood tubes 301, it can be supplied to the other both-side blood tube 301 through the micro channel 302.

[0205] The micro channel 302 is connected to the lower side of the two both-side blood tubes 301, respectively, so that the two both-side blood tubes 301 can be connected.

[0206] Such a micro channel 302 connects the two both-side blood tubes 301 and has a length in the left-right direction so that blood can flow, and can be formed in a curved shape.

[0207] This is because, when the micro channel 302 is formed in a straight line, a fluctuation can occur in the blood in each of the two blood tubes 301 at the same blood level due to the limitation of having no ability to generate an appropriate flow resistance, and thus the micro channel 302 is formed in a curved manner to freely form a flow resistance of a desired size so that no fluctuation occurs therein.

[0208] Specifically, as shown in FIG. 1, the micro channel 302 includes a first curved portion 3020 formed in a forward direction and a second curved portion 3021 formed in a rear direction, and the first curved portion 3020 and the second curved portion 3021 can be formed in a wave shape alternately in left and right directions. Figure 16

[0209] At this time, preferably, the first curved portion 3020 and the second curved portion 3021 are formed in a symmetrical shape, and can be curved in various shapes such as a "U" letter shape, a semicircular shape, a "W" letter shape, a "V" shape, and the like.

[0210] By forming the micro channel 302 in this manner, a fluctuation in flow is minimized, and the flow resistance of the micro channel 302 is easily adjusted, so that when the blood level in each of the two blood tubes is the same, it is possible to adjust the flow rate as desired so that the blood levels can be matched.

[0211] On the other hand, when the amount of blood to be measured is small, the flow speed is increased by reducing the flow resistance, and conversely, when the amount of blood is large, the flow speed is reduced by increasing the flow resistance, and thus only a certain flow speed is maintained, so that a certain blood viscosity can be measured, and thus the adjustment of the flow resistance of the micro channel 302 is very important.

[0212] In the past, in order to adjust the flow speed, a method of adjusting the flow resistance by reducing the size of the channel or increasing the roughness inside the channel has been used, but these methods have limitations in adjusting the flow resistance to a desired size.

[0213] However, in the present application, the total number of the first curved portion and the second curved portion, the width W of the first curved portion and the second curved portion, and the pitch L of the micro channel are adjusted by forming the micro channel 302 having the structure as described above, and thus the flow resistance of the micro channel 302 can be easily adjusted as desired.

[0214] For example, the flow speed can be adjusted to be slower or faster by increasing the total number of the first curved portion and the second curved portion to increase the flow resistance or reducing the total number of the first curved portion and the second curved portion to reduce the flow resistance.

[0215] ​​Furthermore, the size D of the microchannel 302 can be at least 0.8 mm. Since blood is a mixture of water-like plasma components mixed with red blood cells, white blood cells, platelets, etc., when the microchannel 302 is formed with a size less than 0.8 mm, red blood cells, white blood cells, platelets, etc., only aggregate in the center of the microchannel 302, thus ignoring the frictional resistance caused by the cells, and therefore making it impossible to accurately measure blood viscosity.

[0216] Preferably, the microchannel 302 is formed on the bottom surface of the reagent kit body 300 with the lower surface open. In this case, the open lower side of the microchannel 302 can be sealed by the microchannel cap 303.

[0217] This facilitates the fabrication of the curved microchannel 302, and allows the microchannel 302 to be opened by separating the microchannel cap 303, enabling easy cleaning and sterilization after use. Alternatively, blood can be easily washed away and discarded even when disposing of waste, thus maintaining cleanliness.

[0218] The microchannel cap 303 is installed at the lower part of the reagent kit body 300, thereby sealing the open lower side of the microchannel 302 and the blood tubes 301 on both sides.

[0219] like Figure 17 As shown, this microchannel cap 303 may include a sealing protrusion 3030 and a connecting protrusion 3031.

[0220] The sealing protrusion 3030 is formed in a manner corresponding to the shape of the microchannel 302 and the blood vessels 301 on both sides, so that it can be inserted from below into the microchannel 302 and the blood vessels 301 on both sides.

[0221] Furthermore, the sealing protrusion 3030 is formed such that its height is shorter than the depth of the microchannel 302, thereby... Figure 18 As shown, when the binding is performed, there is a gap space, so the blood injected into the blood vessels 301 on both sides can flow along the microchannel 302.

[0222] The protrusion 3031 can be inserted into and bound to the first binding groove 3000 and the second binding groove 3001 of the reagent kit body 300.

[0223] Specifically, the bonding protrusion 3031 may include a first bonding protrusion 3031a and a first bonding protrusion 3031b.

[0224] The first binding protrusion 3031a can be formed on the upper surface of the microchannel cap 303, protruding upward along the outer periphery. Thus, the first binding protrusion 3031a is inserted into the first binding groove 3000 of the reagent kit body 300, thereby enabling the reagent kit body 300 and the microchannel cap 303 to be bound together.

[0225] The first coupling protrusion 3031b for making the coupling between the microchannel cover 303 and the kit body 300 more robust is formed adjacent to the first coupling protrusion 3031a and is formed in a zigzag manner along the length direction from the front side and the rear side and is inserted into the second coupling groove 3001.

[0226] In addition, the second coupling protrusion 3031b can be formed in a manner that the upper surface thereof is inclined downward from the outside to the inside. Thus, when the second coupling protrusion 3031b is inserted into the second coupling groove 3001, the coupling force is increased and the microchannel cover 303 can be easily separated when separated.

[0227] The injection cover 304 is inserted into the cover insertion groove 3010 formed on the upper side of the both-side blood tube 301, so that when blood is injected into the both-side blood tube 301 with the pipette portion 81, external air is prevented from being injected together with the blood into the both-side blood tube, so that the generation of bubbles in the blood can be prevented. Thus, the bubbles generated in the blood can be prevented from hindering the flow of the blood.

[0228] Such an injection cover 304 can include a blood injection hole 3040 and a friction protrusion 3041.

[0229] Referring to Figure 19 The blood injection hole 3040 can be formed in a manner that it penetrates from the upper surface to the lower surface of the injection cover 304 and can include an upper injection hole 3040a and a lower injection hole 3040b.

[0230] The upper injection hole 3040a is formed on the upper side of the injection cover 304 and has a diameter that is gradually narrowed from the upper end to the lower end, so that an upper wide and lower narrow shape can be formed. Thus, when blood is injected through the pipette portion 81, the inclined structure of the pipette portion 81 is properly fitted to the upper injection hole 3040a, so that the blood is injected in a state of being in close contact with the pipette portion 81 and the upper injection hole 3040a, and thus the inflow of external air together can be prevented.

[0231] The lower injection hole 3040b is formed on the lower side of the injection cover 304 and has a diameter that is gradually narrowed from the lower end to the upper end, so that an upper narrow and lower wide shape can be formed.

[0232] Such a lower injection hole 3040b can be directly connected to the upper injection hole 3040a, but can be connected to each other through an intermediate injection hole. The intermediate injection hole is formed in a manner that the diameter is the same from the upper end to the lower end, so that the lower injection hole 3040b and the upper injection hole 3040a can be connected and in this case, the end portion of the inclined structure of the pipette portion 81 can be in close contact, and thus the inflow of external air can be more effectively blocked.

[0233] Furthermore, the lower injection hole 3040b can be formed such that the diameter of the lower injection hole 3040b is larger than that of the upper injection hole 3040a.

[0234] Since the lower injection port 3040b is formed as described above, when blood is injected through the pipette section 81, if a small amount of external air flows in, the air can remain in the lower injection port 3040b and will not enter the microchannel 302 along with the blood.

[0235] This can effectively prevent the formation of air bubbles in the blood.

[0236] The friction protrusion 3041 is formed in such a way that it protrudes along the outer peripheral surface of the injection cap 304, and when the injection cap 304 is inserted into the cap insertion groove 3010, the friction makes the fixation more secure and can prevent the entry of external air.

[0237] On the one hand, the blood injection hole 3040 of the injection cap 304 is not limited to the shape described above, and can be formed into other shapes. This will be... Figure 20 Described as an example.

[0238] like Figure 20 As shown in (a), the blood injection hole 3040 of the injection cap 304 is formed into a shape where the diameter of the upper injection hole 3040a gradually narrows from the upper end to the lower end, and the inclination can be formed into an asymmetrical shape. That is, the inclination on the left side can be more pronounced than the inclination on the right side.

[0239] The lower injection hole 3040b is formed to connect to the lower end of the upper injection hole 3040a, and can be formed to have the same diameter from the upper end to the lower end.

[0240] Therefore, when blood is injected into the blood injection port 3040 through the pipette section 81, the blood flows along the side wall surface of the two blood collection tubes 301, thereby preventing blood from splashing inside the two blood collection tubes 301 and preventing a decrease in the accuracy of blood viscosity measurement.

[0241] like Figure 20 As shown in (b), the blood injection hole 3040 of the injection cap 304 can also be formed into a shape that is wider at the top and narrower at the bottom, with the diameter gradually narrowing from the top to the bottom.

[0242] In this case, the blood injection hole 3040 can be formed in a left-right symmetrical inclined shape in a cross section, but is not limited thereto, and can also be formed in a left-right asymmetrical inclined shape. In this case, when blood is injected into the blood injection hole 3040 by the pipette portion 81, the blood can be injected along the wall surface of the both-side blood collection tube 301, thereby minimizing the phenomenon that the blood splashes against the wall surface inside the both-side blood collection tube 301, and the error of the viscosity measurement can be reduced.

[0243] As shown in (c) of FIG. 10, the blood injection hole 3040 of the injection cap 304 can also be formed in an upper-narrow lower-wide shape in which the diameter is gradually narrowed from the lower end to the upper end. Figure 20

[0244] As shown in (d) of FIG. 10, the blood injection hole 3040 of the injection cap 304 can also be formed in which the diameter is the same from the upper end to the lower end. At this time, the blood injection hole 3040 can be formed in which the diameter is smaller than the maximum diameter of the pipette tip of the pipette portion 81. Thereby, when blood is injected, the upper side of the blood injection hole 3040 is sealed by the pipette tip, so that the inflow of external air can be blocked. Figure 20

[0245] Further, the blood injection hole 3040 can be formed at the center or one side of the injection cap 304, so that it can be formed so that the side wall surface of the blood injection hole 3040 corresponds to the position of the side wall surface of the both-side blood collection tube 301.

[0246] As described above, when the blood injection hole 3040 is formed at one side of the injection cap 304, the blood can be injected along the wall surface of the both-side blood collection tube 301, so that the phenomenon that the blood splashes inside the both-side blood collection tube 301 can be minimized.

[0247] As described above, the multi-channel blood viscosity measurement device according to the embodiment of the present application can automatically measure the viscosity of the blood sample contained in the blood collection tube without an additional operation of the device operator, and can process the waste kit after measuring the blood viscosity, so that it can be efficient when a large number of blood samples are measured.

[0248] Furthermore, since the viscosity measurement of the blood sample is uniformly performed, the viscosity measurement accuracy of each blood sample can be improved.

[0249] Further, since the viscosity measurement of more than one blood sample can be simultaneously performed, the working time can be further shortened.

[0250] ​​The embodiments of the present application have been described above with reference to the accompanying drawings, but it will be understood by those skilled in the art that the present application can be carried out in other specific forms without changing the technical idea or essential technical features of the present application. Therefore, the above-described embodiments are illustrative in all aspects, and are not restrictive.

Claims

1. A multi-channel blood viscosity measurement device, characterized by, Comprising: a blood sample pre-processing section which scans and shakes a blood collection tube, and then separates a blood collection tube cap; a blood sample transfer section which moves a blood collection tube placed by the blood sample pre-processing section; a blood viscosity measurement section which is installed with a blood viscosity measurement kit, and measures the viscosity of a blood sample injected, and includes one or more channels; and a blood sample post-processing section which installs the blood viscosity measurement kit on the blood viscosity measurement section, sucks a blood sample of a blood collection tube transferred by the blood sample transfer section, and injects it into the installed blood viscosity measurement kit, the blood sample post-processing section comprising: a kit clamp section which can be used to clamp or place the blood viscosity measurement kit; a pipette section which is installed with a pipette tip, and sucks a blood sample of a transferred blood collection tube to inject it into the installed blood viscosity measurement kit; and a post-processing position adjustment section which is connected with the kit clamp section and the pipette section, and is used to adjust the positions of the kit clamp section and the pipette section.

2. The multi-channel blood viscosity measurement device according to claim 1, wherein the blood sample pre-processing section comprises: a pre-processing clamp section which can clamp and rotate the blood collection tube; and a pre-processing position adjustment section which is used to adjust the position of the pre-processing clamp section.

3. The multi-channel blood viscosity measurement device according to claim 2, wherein the pre-processing clamp section comprises: a pre-processing clamp which can clamp or place the blood collection tube; a first rotation section which can rotate the pre-processing clamp around a z-axis; and a second rotation section which can rotate the pre-processing clamp around an x-axis or a y-axis.

4. The multi-channel blood viscosity measurement device according to claim 2, wherein the pre-processing position adjustment section comprises: a pre-processing up-down adjustment section which can adjust the position of the pre-processing clamp section in an up-down direction; a pre-processing left-right adjustment section which can adjust the position of the pre-processing clamp section in a left-right direction; and a pre-processing front-rear adjustment section which can adjust the position of the pre-processing clamp section in a front-rear direction; one or more of them.

5. The multi-channel blood viscosity measurement device according to claim 1, wherein the blood sample transfer section comprises: a transfer clamp section which places a blood collection tube through the blood sample pre-processing section; and a transfer unit which is connected with the transfer clamp section, and transfers the placed blood collection tube.

6. The multi-channel blood viscosity measurement device according to claim 1, wherein the channel of the blood viscosity measurement section comprises: a kit installation member which is used to install the blood viscosity measurement kit; a viscosity measurement unit which is internally inserted with the kit installation member installed with the blood viscosity measurement kit, and is used to measure the viscosity of a blood sample injected into the blood viscosity measurement kit; and a kit insertion unit which inserts the kit installation member into the viscosity measurement unit, or pulls the kit installation member out of the viscosity measurement unit. ​ 7. The multi-channel blood viscosity measuring apparatus according to claim 1, wherein the post-treatment position adjustment section includes one or more of: a post-treatment up-down adjustment section that adjusts the positions of the reagent kit holder section and the pipette section in the up-down direction; a post-treatment left-right adjustment section that adjusts the positions of the reagent kit holder section and the pipette section in the left-right direction; and a post-treatment front-rear adjustment section that adjusts the positions of the reagent kit holder section and the pipette section in the front-rear direction.

8. The multi-channel blood viscosity measuring apparatus according to claim 7, wherein the post-treatment up-down adjustment section includes: a reagent kit up-down adjustment section that is connected to the reagent kit holder section and adjusts the position of the reagent kit holder section in the up-down direction; and a comprehensive up-down adjustment section that is connected to the reagent kit up-down adjustment section and the pipette section and adjusts the positions of the reagent kit holder section and the pipette section in the up-down direction.

9. The multi-channel blood viscosity measuring apparatus according to claim 1, further comprising: a control section that controls the operations of the blood sample pre-treatment section, the blood sample transfer section, the blood viscosity measuring section, and the blood sample post-treatment section; and a monitoring section that monitors the viscosity measurement results measured by the blood viscosity measuring section. further comprising: a blood sample mounting section that mounts one or more blood collection tubes. further comprising:

10. The multi-channel blood viscosity measurement device as defined in claim 1, wherein, a blood viscosity measuring cartridge for storing a blood viscosity measuring reagent cartridge before use. further comprising:

11. The multi-channel blood viscosity measurement device as defined in claim 1, wherein, a pipette tip storage section for storing a pipette tip before use. further comprising:

12. The multi-channel blood viscosity measurement device as defined in claim 1, wherein, a waste treatment section that accommodates a blood viscosity measuring reagent cartridge in which blood sample viscosity measurement has been completed in the blood viscosity measuring section. ​ 13. The multi-channel blood viscosity measurement device as defined in claim 1, wherein, ​ ​

Images