Left atrial appendage occluder skeleton manufacturing method and manufacturing system

Abstract

The present invention discloses a left atrial appendage occluder skeleton manufacturing method and manufacturing system. The manufacturing method reversely designs the matrix, pressing mold, primary shaping mold, finished product shaping mold and electrospark forming conductive electrode through the finished left atrial appendage occluder skeleton, which can better ensure the skeleton processing accuracy and controllability; the non-contact processing method of electrospark forming is used to remove material, which can realize the one-piece molding manufacturing of the left atrial appendage occluder skeleton and achieve precise control of the finished product shape, thereby effectively improving the quality of the finished left atrial appendage occluder skeleton. Compared with the skeleton preparation method in the prior art, it has higher flexibility and reliability, and improves the manufacturing accuracy and reliability of the finished left atrial appendage occluder skeleton. The left atrial appendage occluder skeleton manufacturing system has a novel and reasonable structure and is easy to use and operate. It is mainly used for the one-piece molding manufacturing of the finished left atrial appendage occluder skeleton and achieves precise control of the finished skeleton shape.

Description

Technical Field

[0001] The present invention belongs to the field of medical devices and relates to a left atrial appendage occluder skeleton manufacturing technology, and in particular to a left atrial appendage occluder skeleton manufacturing method and manufacturing system. Background Art

[0002] Atrial fibrillation, short for "atrial fibrillation," is one of the most common cardiac arrhythmias. Blood clots caused by AF are the most common cause of stroke. Currently, the most effective medical treatment for AF is through medication and surgery. Studies have shown that the majority of blood clots in patients with AF develop in the left atrial appendage (LAA). The LAA is a remnant of the primitive left atrium from the embryonic stage. Due to its structural characteristics, the inward movement of the atrial appendage wall hinders blood flow during AF, leading to thrombosis. To prevent thrombosis, most patients take long-term anticoagulant medication to reduce the risk of thrombosis. However, anticoagulants cannot completely prevent LAA thrombosis and carry other risks. Therefore, interventions such as LAA ligation and percutaneous LAA occlusion have been the subject of extensive research both domestically and internationally in recent years. Long-term clinical trials have demonstrated non-inferiority to other interventions. Over the past few decades, domestic and international companies have developed LAA occluders in a variety of shapes and structures, including umbrella-shaped, disc-shaped, and plug-shaped. Some plug-type LAA occluders primarily consist of a metal skeleton and a mesh-like biodegradable membrane. The skeleton is crucial to the device's occlusion effectiveness after deployment. The metal skeleton and its barbed spines ensure the device's securement and support once inserted into the LAA.

[0003] Since the curved surface morphology of the left atrial appendage occluder skeleton is very complex, the traditional method is mainly to manufacture it by splicing after separate processing. At the same time, some researchers have also processed multiple metal wires into wires with barbs and then braided them into shape. It is easier to ensure the accuracy of single skeleton processing through separate manufacturing, but the assembly of the skeleton requires connecting multiple parts through screws, welding, bonding, etc. However, the small size of the parts brings greater challenges to processing and assembly, and the reliability during use will also be reduced. The density of the skeleton mesh can be well controlled by weaving metal wires, but the weaving process and overall preparation are relatively complicated. The length of the various metal wires used in the weaving needs to be accurately calculated before weaving, which makes it difficult to meet the demand for personalized size customization.

[0004] As can be seen from the above, the existing LAA occluder frame manufacturing methods of separate processing and splicing and weaving manufacturing methods are unable to achieve the one-piece manufacturing of the LAA occluder frame, which makes the manufacturing process cumbersome, increases the manufacturing difficulty, and has low precision and poor reliability of the finished product. The present invention aims to propose a novel LAA occluder frame manufacturing method to solve the problem that the current LAA occluder frame is difficult to manufacture in one piece. Summary of the Invention

[0005] The purpose of the present invention is to provide a left atrial appendage occluder skeleton manufacturing method and manufacturing system, which can realize the one-piece molding manufacturing of the left atrial appendage occluder skeleton, thereby solving the problems of the existing left atrial appendage occluder skeleton manufacturing technology, such as complicated manufacturing process, high manufacturing difficulty, low finished product precision and poor reliability.

[0006] To achieve the above object, the present invention provides the following solutions:

[0007] The present invention provides a method for manufacturing a left atrial appendage occluder skeleton, comprising:

[0008] According to the outline of the finished mesh skeleton with hooks, a mesh skeleton semi-finished product model and a surface insulating base that are compatible with its shape and size are designed and manufactured;

[0009] Designing and manufacturing a pressing mold, a primary shaping mold, a finished product shaping mold, and an electrospark forming conductive electrode based on the predicted model of the substrate and the mesh skeleton semi-finished product, wherein the cavities of the pressing mold, the primary shaping mold, and the finished product shaping mold are all adapted to the outer contour of the substrate, and the processing portion of the electrospark forming conductive electrode is adapted to the outer contour of the substrate;

[0010] Pressing the original plate into a primary shell having the initial shape of the left atrial appendage occluder skeleton by the pressing die and the base;

[0011] Preliminary shaping of the primary shell is performed using the primary shaping mold and the base to form a preliminarily shaped shell;

[0012] The excess material on the outer peripheral curved surface of the preliminarily formed shell is removed by electrospark machining using the electrospark forming conductive electrode to produce a mesh skeleton semi-finished product with a barb forming portion reserved;

[0013] The barb-forming portion reserved on the mesh frame semi-finished product is bent into barbs to produce a mesh frame semi-finished product with hooks;

[0014] The finished product shaping mold and the base are used to shape the semi-finished product of the mesh frame with hooks into a finished product to produce the finished product of the mesh frame with hooks.

[0015] Optionally, the electrospark formed conductive electrode is designed and manufactured based on an anti-copy processing technology.

[0016] Optionally, after the electrospark formed conductive electrode is manufactured, it is further divided into an electrospark formed conductive electrode 1 adapted to the top contour of the primary shell and an electrospark formed conductive electrode 2 adapted to the side contour of the primary shell; the mesh skeleton semi-finished product with the barb forming portion reserved includes:

[0017] The excess material on the top curved surface of the primary shell is removed by electrospark machining using the electrospark forming conductive electrode 1 to form a mesh shell semi-finished product 1;

[0018] The excess material on the curved surface of one side of the mesh shell semi-finished product is removed by electrospark machining using the second electrospark forming conductive electrode to form a second mesh shell semi-finished product;

[0019] All excess materials on the two side curved surfaces of the mesh shell semi-finished product are removed by electrospark machining in batches to produce the mesh skeleton semi-finished product.

[0020] Optionally, the substrate is made of ceramic; or, the substrate is made of metal or non-metal, and then a non-conductive coating is coated on the surface.

[0021] Optionally, the original plate is a nickel-titanium memory alloy plate that is cut and pressed according to the material size required by the primary shell; the preliminary shaping and the finished product shaping are both performed by heat treatment technology for memory shaping.

[0022] The present invention also proposes a left atrial appendage occluder skeleton manufacturing system, comprising a barb bending mechanism and a base, a pressing mold, a primary shaping mold, a finished product shaping mold and an electrospark forming conductive electrode manufactured based on any one of the above-mentioned left atrial appendage occluder skeleton manufacturing methods, wherein the pressing mold cooperates with the base to produce a primary shell having the initial form of the left atrial appendage occluder skeleton; the primary shaping mold cooperates with the base to perform preliminary shaping on the primary shell to produce a preliminary shaped shell; the electrospark forming conductive electrode is used to remove excess material on the outer peripheral curved surface of the preliminary shaped shell to produce a mesh skeleton semi-finished product with a reserved barb forming part; the barb bending mechanism is used to bend the barb forming part to produce a hooked mesh skeleton semi-finished product; the finished product shaping mold cooperates with the base to perform finished shaping on the hooked mesh skeleton semi-finished product to produce the hooked mesh skeleton finished product.

[0023] Optionally, the pressing mold includes an upper pressing mold and a lower pressing mold; the primary shaping mold includes an upper primary shaping mold and a lower primary shaping mold; the finished product shaping mold includes bolts and a finished product shaping upper mold, a finished product shaping middle mold and a finished product shaping lower mold arranged in sequence from top to bottom, and the bolts are used to connect and fasten the finished product shaping upper mold, the finished product shaping middle mold and the finished product shaping lower mold when the finished product shaping mold performs finished shaping on the semi-finished product of the mesh skeleton with hooks;

[0024] The inner walls of the mold cavities of the upper pressure mold, the lower pressure mold, the upper primary shaping mold, the lower primary shaping mold, the finished product shaping upper mold, the finished product shaping middle mold and the finished product shaping lower mold are all provided with flow channels for circulation of hot air flow, and the flow channels include a number of auxiliary air flow channels distributed according to the grid patterns of the finished product of the hooked mesh skeleton, and all the auxiliary air flow channels of any one of the upper pressure mold, the upper primary shaping mold and the finished product shaping upper mold converge at one point at the top of the corresponding mold to form a main air flow channel.

[0025] Optionally, the barb bending mechanism includes a bending fixed circular rod for being arranged in contact with one side of the barb forming portion and a bending movable circular rod for being arranged in contact with the other side of the barb forming portion, and the bending movable circular rod is driven to roll along the circumference of the bending fixed circular rod to bend the barb forming portion to form an upwardly curled arc barb;

[0026] The lower edge of the cavity of the finished product shaping middle mold is provided with an annular boss adapted to the inner circular surface of the arc barb, and the upper edge of the cavity of the finished product shaping lower mold is provided with an annular groove adapted to the outer circular surface of the arc barb.

[0027] Optionally, the electro-spark forming conductive electrode includes electro-spark forming conductive electrode 1 and electro-spark forming conductive electrode 2, the electro-spark forming conductive electrode 1 is used to perform electro-spark machining to remove excess material on the top curved surface of the primary shell, and the electro-spark forming conductive electrode 2 is used to perform electro-spark machining to remove excess material on the side curved surface of the primary shell.

[0028] Optionally, a magnet is embedded in the bottom of the base, and the magnet is used to adsorb and fix the base in the cavity of the pressing mold, the primary shaping mold or the finished product shaping mold.

[0029] Compared with the prior art, the present invention has achieved the following technical effects:

[0030] The method for manufacturing a left atrial appendage occluder skeleton proposed in the present invention reversely designs a matrix, a pressing mold, a primary shaping mold, a finished product shaping mold and an electrospark forming conductive electrode through the finished left atrial appendage occluder skeleton, which can better ensure the skeleton processing accuracy and controllability; the non-contact processing method of electrospark forming is used to remove material, which can realize the one-piece molding manufacturing of the left atrial appendage occluder skeleton and achieve precise control of the finished product shape, thereby effectively improving the quality of the finished left atrial appendage occluder skeleton. Compared with the skeleton preparation method in the prior art, it has higher flexibility and reliability, can effectively avoid the problems of easy cracking and fatigue fracture failure of the skeleton caused by connection methods such as welding, gluing and weaving, and improves the manufacturing accuracy and reliability of the finished left atrial appendage occluder skeleton.

[0031] At the same time, in the manufacturing method of the left atrial appendage occluder skeleton disclosed in the present invention, the precise estimation of the raw materials is avoided by pressing the original plate material, the probability of deformation of the primary shell during the processing is reduced by preliminary heat treatment memory shaping to ensure the processing accuracy, and the precise one-piece molding preparation of the left atrial appendage occluder skeleton is achieved by the electric spark forming processing method. By reserving the barb forming material in the processing stage of the skeleton, the problem of easy cracking, breakage and failure caused by the traditional method of preparing the barbs and various parts of the skeleton in advance and then connecting them by welding, gluing or weaving is avoided.

[0032] The method for manufacturing a left atrial appendage occluder skeleton disclosed in the present invention utilizes electrospark forming processing technology to directly remove material from a shell having the outline of the left atrial appendage occluder skeleton, thereby producing an integrally formed left atrial appendage occluder skeleton finished product. This not only solves the problem that the left atrial appendage occluder skeleton cannot be manufactured in one piece, but also simplifies the process. Compared with the existing left atrial appendage occluder skeleton preparation method, it avoids the tedious process of first manufacturing and then assembling, and also reduces the difficulty of manufacturing small components and the difficulty of shaping the overall skeleton.

[0033] The method for manufacturing a left atrial appendage occluder skeleton disclosed in the present invention has better versatility and higher feasibility, can adapt to the manufacture of different types of left atrial appendage occluder skeleton finished products, and reduces manufacturing costs.

[0034] The left atrial appendage occluder skeleton manufacturing system proposed in the present invention has a novel and reasonable structure and is easy to use and operate. It is mainly used for the one-piece molding manufacturing of the finished left atrial appendage occluder skeleton and realizes precise control of the shape of the finished skeleton, thereby effectively improving the manufacturing quality of the finished left atrial appendage occluder skeleton. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0036] Figure 1 A cross-sectional diagram illustrating the positional relationship between the base and the original plate disclosed in an embodiment of the present invention;

[0037] Figure 2 An exploded schematic diagram of the positional relationship between the base and the original plate disclosed in an embodiment of the present invention;

[0038] Figure 3 A schematic diagram of the press-forming principle of the primary housing disclosed in an embodiment of the present invention (the diagram shows the positional relationship between the various parts during the press-forming stage);

[0039] Figure 4 An exploded diagram illustrating the positional relationship between various parts during the pressing and forming stage disclosed in an embodiment of the present invention;

[0040] Figure 5 A cross-sectional diagram illustrating the positional relationship between various parts during the initial heat treatment memory shaping stage disclosed in an embodiment of the present invention;

[0041] Figure 6 This is an exploded schematic diagram of the positional relationship between various parts in the preliminary finalization stage disclosed in an embodiment of the present invention;

[0042] Figure 7 A schematic diagram of the internal structure of the upper primary shaping mold disclosed in an embodiment of the present invention;

[0043] Figure 8 An exploded schematic diagram of the positional relationship between various parts during the reverse copying stage of electrospark machining of the primary shell top disclosed in an embodiment of the present invention;

[0044] Figure 9 An exploded schematic diagram of the positional relationship between various parts during the reverse copy machining stage of the primary shell side EDM disclosed in an embodiment of the present invention;

[0045] Figure 10 This is a schematic diagram of the processing of the mesh skeleton semi-finished product barb preparation stage disclosed in an embodiment of the present invention;

[0046] Figure 11 This is an exploded schematic diagram of the positional relationship between the various parts of the hook mesh skeleton semi-finished product disclosed in an embodiment of the present invention during the finalization stage of the finished product;

[0047] Figure 12This is a cross-sectional diagram illustrating the positional relationship between various parts of a semi-finished mesh skeleton with hooks disclosed in an embodiment of the present invention during the finalization stage of the finished product.

[0048] Wherein, the accompanying drawings are marked as follows:

[0049] 1-base, 2-original plate, 3-primary shell, 4-lower pressing die, 5-upper pressing die, 6-lower primary shaping die, 7-upper primary shaping die, 701-main air flow channel, 702-gap, 703-auxiliary air flow channel, 8-net skeleton semi-finished product, 9-net skeleton finished product with hook, 901-barb, 10-electro-spark forming conductive electrode one, 11-electro-spark forming conductive electrode two, 12-net shell semi-finished product one, 13-magnet, 14-net shell semi-finished product two, 15-mounting base plate, 16-fastening cover, 17-net skeleton semi-finished product with hook, 18-bending fixed round rod, 19-bending movable round rod, 20-finished product shaping upper die, 21-finished product shaping middle die, 2101-annular boss, 22-finished product shaping lower die, 2201-annular groove, 23-locating pin, 24-nut, 25-bolt. DETAILED DESCRIPTION

[0050] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0051] One of the purposes of the present invention is to provide a method for manufacturing a left atrial appendage occluder skeleton, which can realize the one-piece molding manufacturing of the left atrial appendage occluder skeleton, thereby solving the problems of the existing left atrial appendage occluder skeleton manufacturing technology, such as complicated manufacturing process, high manufacturing difficulty, low finished product precision and poor reliability.

[0052] Another object of the present invention is to provide a left atrial appendage occluder skeleton manufacturing system, which can realize the one-piece molding manufacturing of the left atrial appendage occluder skeleton, thereby solving the problems of the existing left atrial appendage occluder skeleton manufacturing technology, such as complicated manufacturing process, high manufacturing difficulty, low finished product precision and poor reliability.

[0053] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0054] Example 1

[0055] This embodiment provides a method for manufacturing a left atrial appendage occluder skeleton, which mainly includes the following steps:

[0056] S1. Design and manufacture a mesh skeleton semi-finished product model (without barb structure) and a surface-insulated base 1 according to the outline of the finished mesh skeleton with hooks 9 to be manufactured;

[0057] S2. Design and manufacture a pressing mold, a primary shaping mold, a finished product shaping mold, and an electrospark forming conductive electrode based on the estimated model of the substrate 1 and the mesh skeleton semi-finished product, wherein the cavities of the pressing mold, the primary shaping mold, and the finished product shaping mold are all adapted to the outer contour of the substrate 1, and the processing portion of the electrospark forming conductive electrode is adapted to the outer contour of the substrate 1;

[0058] S3, pressing the original plate 2 into a primary shell 3 having the initial shape of the left atrial appendage occluder skeleton by using a pressing mold and a base 1;

[0059] S4, preliminarily shaping the primary shell 3 using the primary shaping mold and the base 1 to form a preliminarily shaped shell;

[0060] S5. Using an electrospark forming conductive electrode, remove excess material from the outer peripheral curved surface of the preliminarily formed shell by electrospark machining, thereby forming a mesh skeleton semi-finished product 8 with a barb-shaped portion reserved therefor.

[0061] S6, bending the barb-shaped portion reserved on the mesh skeleton semi-finished product 8 into barbs 901 to produce a mesh skeleton semi-finished product 17 with hooks;

[0062] S7, shaping the hook mesh skeleton semi-finished product 17 into a finished product through the finished product shaping mold and the base 1 to produce a hook mesh skeleton finished product 9.

[0063] The above-mentioned left atrial appendage occluder skeleton manufacturing method first presses the original plate material 2 into a primary shell 3 with the initial shape of the skeleton through a pressing mold and a base 1, and then performs preliminary shaping of the primary shell 3 through a primary shaping mold to ensure the accuracy of subsequent processing, and then processes a mesh skeleton semi-finished product 8 without barbs through an electrospark forming process, and then bends out barbs 901 through a barb bending mechanism, and finally performs final shaping through a finished product shaping mold to obtain a finished product 9 of a mesh skeleton with hooks. The above-mentioned finished product 9 of the mesh skeleton with hooks is generally a mesh skeleton with an open end. During its forming and manufacturing process, the open end is often facing downward, and the end opposite to the opening is facing upward. The "top of the primary shell 3" mentioned below is the end of the finished product 9 of the mesh skeleton with hooks opposite to its opening. The above-mentioned left atrial appendage occluder skeleton manufacturing method solves the problem that the left atrial appendage occluder skeleton cannot be manufactured as a whole through the manufacturing method of electrospark forming processing, and at the same time can meet the demand for personalized customization of the left atrial appendage occluder skeleton in any shape.

[0064] In this embodiment, step S8 is added after step 7, which is mainly used to clean and decontaminate the finished product 9 of the hook mesh skeleton produced in step 7.

[0065] In this embodiment, the EDM conductive electrode is a contoured electrode designed and manufactured based on the principles of reverse copy machining. The EDM conductive electrode is made of a conductive material, typically graphite, brass, copper, titanium alloy, etc., and the EDM machining polarity is always positive. In actual operation, the EDM conductive electrode's edge detection function uses a voltage short-circuit signal to determine contact, while the EDM conductive electrode's penetration detection function uses voltage and current signals to determine and ensure complete material removal.

[0066] In this embodiment, after the electrospark forming conductive electrode is manufactured, it is further divided into an electrospark forming conductive electrode 1 10 adapted to the top contour of the primary shell 3 and an electrospark forming conductive electrode 2 11 adapted to the side contour of the primary shell 3 according to the specific processing technology. The so-called "processing technology" is, on the one hand, related to the reserved discharge gap (which can be considered as a processing allowance) corresponding to the electrode splitting and processing parameters, that is, whether the split part can be reverse-copied without interference during the movement in space; on the other hand, the splitting needs to consider the processing efficiency and processing quality for optimization. For those skilled in the art, this is a routine operation and will not be described in detail here. Based on the electrospark forming conductive electrode 1 10 and the electrospark forming conductive electrode 2 11 formed after splitting, when preparing the above-mentioned mesh skeleton semi-finished product 8 with reserved barb forming parts in step S5, the following steps are specifically included:

[0067] S51, removing excess material from the top curved surface of the primary shell 3 by electrospark machining using an electrospark forming conductive electrode 10, to form a mesh shell semi-finished product 12;

[0068] S52, using the second electrospark forming conductive electrode 11 to perform electrospark machining on a portion of excess material on the side curved surface of the mesh shell semi-finished product 12 to remove the excess material, thereby forming the second mesh shell semi-finished product 14;

[0069] S53, removing all excess material on the side curved surface of the mesh shell semi-finished product 2 14 by reverse-copying through electric spark machining in batches to produce a mesh skeleton semi-finished product 8.

[0070] In this embodiment, substrate 1 is made of, but not limited to, non-conductive ceramic. It can also be any other non-conductive substrate that meets insulation requirements, such as various metals or non-metals coated with a non-conductive coating. In this embodiment, the aforementioned pressing mold comprises an upper pressing mold 5 and a lower pressing mold 4; the primary shaping mold comprises an upper primary shaping mold 7 and a lower primary shaping mold 6; and the finished product shaping mold comprises, arranged from top to bottom, a finished product shaping upper mold 20, a finished product shaping middle mold 21, and a finished product shaping lower mold 22. The original plate 2 is preferably a nickel-titanium memory alloy plate cut and pressed according to the material size required by the primary shell 3; based on this memory alloy material, the preliminary shaping in step S4 and the finished product shaping in step S7 are both memory shaped using heat treatment technology, that is, the primary shell 3 with the initial form of the left atrial appendage occluder skeleton is subjected to preliminary heat treatment memory shaping through the lower primary shaping mold 6, the upper primary shaping mold 7 and the base 1, and the hook mesh skeleton semi-finished product 17 is heat treated and memory shaped through the finished product shaping upper mold 20, the finished product shaping middle mold 21, the finished product shaping lower mold 22 and the base 1 to form the hook mesh skeleton finished product 9. Since the finished product shaping mold is used for shaping the hook mesh skeleton semi-finished product 17, the finished product shaping mold has a accommodating cavity adapted to the barb 901 structure, such as Figure 12 As shown in the annular boss 2101 and the annular groove 2201, when the finished product shaping middle mold 21 and the finished product shaping lower mold 22 are in the mold closing state, a barb 901 accommodating cavity that is adapted to the shape and size of the barb 901 is formed between the annular boss 2101 of the finished product shaping middle mold 21 and the annular groove 2201 of the finished product shaping lower mold 22, and the annular boss 2101 and the annular groove 2201 cooperate to achieve the finished product shaping of the barb 901.

[0071] The following is an example of a nickel-titanium shape memory alloy plate as the original plate 2 to specifically describe the manufacturing method of the left atrial appendage occluder frame in this embodiment. The actual operation specifically includes the following steps:

[0072] S1: Design the shape of the base 1 and the estimated model of the mesh skeleton semi-finished product 8 according to the finished product 9 of the mesh skeleton with hooks;

[0073] S2: Based on the expected model of the base 1 and the mesh skeleton semi-finished product 8, a lower pressing die 4, an upper pressing die 5, a lower primary shaping die 6, an upper primary shaping die 7, a finished product shaping upper die 20, a finished product shaping middle die 21, and a finished product shaping lower die 22 are designed; at the same time, an EDM conductive electrode is designed based on the reverse copy principle, and the electrode is segmented according to the process requirements of the hook mesh skeleton finished product 9 to obtain an EDM conductive electrode 10 and an EDM conductive electrode 2 11;

[0074] S3: estimating the material dimensions required for manufacturing the primary shell 3 having the initial form of the left atrial appendage occluder skeleton based on the estimated model of the mesh skeleton semi-finished product 8, and preliminarily cutting and pressing the raw sheet 2; pressing the raw sheet 2 into the primary shell 3 having the initial form of the left atrial appendage occluder skeleton using the lower pressing mold 4, the upper pressing mold 5 and the base 1;

[0075] S4: The base body 1 with the primary shell 3 is placed between the lower primary shaping mold 6 and the upper primary shaping mold 7, and hot air is passed through the main air flow channel 701 into the shaping mold to perform preliminary heat treatment memory shaping of the primary shell 3 to obtain a preliminary shaped shell;

[0076] S5: The base body 1 with the preliminary shaped shell is fixed on the lower pressing mold 4 by the magnet 13, and the primary shell 3 with the initial shape of the left atrial appendage occluder skeleton, that is, the upper half of the preliminary shaped shell, is subjected to electrospark machining through the electrospark forming conductive electrode 10 installed on the main shaft of the machine tool, and the excess material on the complex curved surface is removed by reverse copying to form a mesh shell semi-finished product 12; then the base body 1 with the mesh shell semi-finished product 12 is fixed on the mounting base plate 15, and fastened by the fastening cover 16, and then the mesh shell semi-finished product 12 is fixed by the electrospark forming conductive electrode 11. The side portion is subjected to electro-spark machining, and excess material on the curved surface is removed by reverse copying to form a mesh shell semi-finished product 14; the machine tool rotates the turntable to drive the mounting base plate 15 to rotate and switch the machining surface of the mesh shell semi-finished product 12, and repeats the electro-spark machining steps of the side portion of the mesh shell semi-finished product 12 until all excess material on the side portion of the mesh shell semi-finished product 12 is removed, and finally a mesh skeleton semi-finished product 8 with a barb forming portion is formed; when necessary, the spindle is rotated to switch the machining portion of the electro-spark forming conductive electrode 11 to avoid severe wear of a certain machining portion of the electro-spark forming conductive electrode 11, which may lead to machining failure;

[0077] S6: The barb bending portion reserved on the mesh skeleton semi-finished product 8 is bent into barbs 901 by the barb bending fixed rod 18 and the bending movable rod 19 of the barb bending mechanism, thereby producing a hooked mesh skeleton semi-finished product 17;

[0078] S7: The base 1 with the hook mesh skeleton semi-finished product 17 is mounted on the finished product shaping lower mold 22 through the magnet 13, and then the finished product shaping middle mold 21 and the finished product shaping upper mold 20 are installed in sequence. The positional relationship between the mold blocks is ensured by the positioning pin 23, and the finished product shaping lower mold 22, the finished product shaping middle mold 21 and the finished product shaping upper mold 20 are fixed by the bolt 25 and the nut 24. Finally, hot air is passed into the main air flow channel at the top of the finished product shaping mold to perform finished product heat treatment memory shaping of the hook mesh skeleton semi-finished product 17, thereby obtaining the hook mesh skeleton finished product 9;

[0079] S8: The finished product 9 of the mesh skeleton with hooks is cleaned and decontaminated, thereby completing the manufacturing process of the finished product 9 of the mesh skeleton with hooks.

[0080] From the above, it can be seen that the method for manufacturing the left atrial appendage occluder skeleton proposed in this embodiment is to first press the original plate into a primary shell with the initial shape of the left atrial appendage occluder skeleton through an upper pressing mold, a lower pressing mold and a base; then the primary shell is subjected to preliminary heat treatment memory shaping through an upper primary shaping mold, a lower primary shaping mold and a base; thereafter, through an electrospark forming processing method, the excess material on the primary shell after preliminary shaping is removed by repeated reverse copying processing in multiple steps to manufacture a mesh shell semi-finished product with a part to be bent (i.e., a barb forming part); then the barb is bent out by a barb bending mechanism to form a mesh skeleton semi-finished product with hooks; then the mesh skeleton semi-finished product with hooks is subjected to finished heat treatment memory shaping through a finished product shaping upper mold, a finished product shaping middle mold, a finished product shaping lower mold and a base, and finally the manufacture of the finished mesh skeleton with hooks is completed after cleaning. This method for manufacturing the skeleton of the left atrial appendage occluder solves the problem that the existing technology is difficult to realize the one-piece manufacturing of the skeleton of the left atrial appendage occluder, and at the same time realizes the demand for personalized customized manufacturing of various types of left atrial appendage occluder skeletons in arbitrary shapes. In this solution, the precise estimation of raw materials is avoided by pressing the original plate material, the probability of deformation of the primary shell during the processing is reduced by preliminary heat treatment memory shaping to ensure processing accuracy, and the precise one-piece molding preparation of the skeleton of the left atrial appendage occluder is achieved by the electric spark forming processing method. By reserving the barb forming material in the processing stage of the skeleton, the problem of easy cracking, breakage and failure caused by the need to prepare the barbs and various parts of the skeleton in advance and then connect them by welding, gluing or weaving in the traditional method is avoided. Compared with the existing technology, this solution has the following specific features:

[0081] Beneficial effects:

[0082] (1) Preparing the rough shell by pressing the original plate and performing preliminary heat treatment to shape it, i.e., the preliminary shaping of the shell in step S4, can avoid the complicated steps of accurately calculating the raw materials and effectively reduce the probability of deformation of the shell during the processing to ensure the processing accuracy;

[0083] (2) The matrix, pressing mold, shaping mold, forming electrode and electrode segmentation are reversely designed through the finished product of the left atrial appendage occluder skeleton, which can better ensure the skeleton processing accuracy and controllability; the non-contact processing method of electrospark forming is used to remove materials, which can realize the one-piece molding manufacturing of the left atrial appendage occluder skeleton and achieve precise control of the finished product shape, thereby effectively improving the quality of the finished product of the left atrial appendage occluder skeleton. Compared with the skeleton preparation method in the prior art, this solution has higher flexibility and reliability, and can effectively avoid the problems of easy cracking and fatigue fracture failure of the skeleton caused by connection methods such as welding, gluing and weaving, thereby improving the manufacturing accuracy and reliability of the finished product of the left atrial appendage occluder skeleton;

[0084] (3) Using the electrospark forming process technology to directly remove material from the shell having the outline of the left atrial appendage occluder skeleton, a one-piece left atrial appendage occluder skeleton product is obtained. The process is simple. Compared with the existing left atrial appendage occluder skeleton preparation method, the tedious process of first manufacturing and then assembling is avoided, and the difficulty of manufacturing small parts and shaping the overall skeleton is reduced.

[0085] (4) The design method and process flow proposed in this scheme have better versatility and higher feasibility, and can adapt to the manufacture of different types of left atrial appendage occluder skeleton finished products, thereby reducing manufacturing costs.

[0086] Example 2

[0087] The present embodiment proposes a left atrial appendage occluder skeleton manufacturing system, including a barb bending mechanism and a base 1, a pressing mold, a primary shaping mold, a finished product shaping mold and an electrospark forming conductive electrode manufactured based on the left atrial appendage occluder skeleton manufacturing method in Example 1, wherein: the surface of the base 1 is insulated, and its shape and size are adapted to the contour of the finished product 9 of the hook mesh skeleton; the cavities of the pressing mold, the primary shaping mold and the finished product shaping mold in the mold closing state are adapted to the outer contour of the base 1, and the processing part of the electrospark forming conductive electrode is adapted to the outer contour of the base 1; the pressing mold is adapted to the base 1 The combination can produce a primary shell 3 with the initial shape of the left atrial appendage occluder skeleton; the primary shaping mold and the base 1 can cooperate to perform preliminary shaping on the primary shell 3 to produce a preliminary shaped shell; the electrospark forming conductive electrode is used to remove excess material on the outer peripheral curved surface of the preliminary shaped shell to produce a mesh skeleton semi-finished product 8 with a barb forming part reserved; the barb bending mechanism is used to bend the barb forming part to produce a hooked mesh skeleton semi-finished product 17; the finished product shaping mold and the base 1 can cooperate to perform finished product shaping on the hooked mesh skeleton semi-finished product 17 to produce a hooked mesh skeleton finished product 9.

[0088] In this embodiment, the above-mentioned pressing mold includes an upper pressing mold 5 and a lower pressing mold 4 distributed up and down; the primary shaping mold includes an upper primary shaping mold 7 and a lower primary shaping mold 6 distributed up and down; the finished product shaping mold includes a bolt 25 and a finished product shaping upper mold 20, a finished product shaping middle mold 21 and a finished product shaping lower mold 22 arranged in sequence from top to bottom. The bolt 25 is used to penetrate the through holes at the four corners of the finished product shaping upper mold 20, the finished product shaping middle mold 21 and the finished product shaping lower mold 22 when the finished product shaping mold performs finished product shaping on the hook mesh skeleton semi-finished product 17, and tightens the matching nut 24 to achieve the connection and fastening of the finished product shaping upper mold 20, the finished product shaping middle mold 21 and the finished product shaping lower mold 22.

[0089] In this embodiment, the inner walls of the mold cavities of the upper pressure mold 5, the lower pressure mold 4, the upper primary shaping mold 7, the lower primary shaping mold 6, the finished product shaping upper mold 20, the finished product shaping middle mold 21 and the finished product shaping lower mold 22 are all provided with flow channels for the circulation of hot air flow, and the flow channels include a number of auxiliary air flow channels 703 distributed according to the grid patterns of the finished product 9 with hook mesh skeleton. All auxiliary air flow channels 703 of any one of the upper pressure mold 5, the upper primary shaping mold 7 and the finished product shaping upper mold 20 are all converged at one point at the top of the corresponding mold to form a main air flow channel 701. The above-mentioned auxiliary air flow channels 703 are groove-type air flow channels, and the main air flow channel 701 is a channel that runs through the top center of the corresponding upper mold. Taking the above primary shaping mold 7 as an example, Figure 7 As shown, the inner wall of the cavity of the upper primary shaping mold 7 is provided with a plurality of auxiliary flow channels 703, with gaps 702 remaining between adjacent auxiliary flow channels 703. The auxiliary flow channels 703 provided on the lower primary shaping mold 6 correspond one-to-one with and are connected to the auxiliary flow channels 703 on the upper primary shaping mold 7. The main flow channels 701 are used for the circulation of heat treatment airflow in and out, the gaps 702 are used to reserve material expansion and to assist in the uniform distribution of the hot airflow, and the auxiliary flow channels 703 are used to quickly circulate the hot airflow and assist in its uniform distribution, so that the hot airflow is evenly distributed throughout the cavity of the primary shaping mold, thereby improving the shaping effect.

[0090] In this embodiment, the barb bending mechanism includes a bending fixed circular rod 18 for being arranged in contact with one side of the barb forming portion and a bending movable circular rod 19 for being arranged in contact with the other side of the barb forming portion. The bending movable circular rod 19 is driven to roll along the circumference of the bending fixed circular rod 18 to bend the barb forming portion into an upwardly curled arc barb 901. The lower edge of the cavity of the finished product shaping middle mold 21 is provided with an annular boss 2101 that is adapted to the inner circular surface of the arc barb 901, and the upper edge of the cavity of the finished product shaping lower mold 22 is provided with an annular groove 2201 that is adapted to the outer circular surface of the arc barb 901. When the finished product shaping middle mold 21 and the finished product shaping lower mold 22 are in the closed mold state, a barb 901 accommodating cavity that is adapted to the shape and size of the barb 901 is formed between the annular boss 2101 of the finished product shaping middle mold 21 and the annular groove 2201 of the finished product shaping lower mold 22, and the annular boss 2101 and the annular groove 2201 cooperate to achieve the finished product shaping of the barb 901.

[0091] In this embodiment, based on the processing requirements of the finished hook mesh frame 9, the EDM conductive electrode is divided into two parts: EDM conductive electrode 1 10 and EDM conductive electrode 2 11. The processing portion of EDM conductive electrode 1 10 is adapted to the top of the finished hook mesh frame 9, i.e., the upper half of the structural contour, and is used to EDM the excess material on the top curved surface of the primary shell 3. The processing portion of EDM conductive electrode 2 11 is adapted to the side wall of the finished hook mesh frame 9, i.e., the lower half of the structural contour, and is used to EDM the excess material on the side curved surface of the primary shell 3. In actual use, EDM conductive electrode 2 11 is used to remove all excess material from the side curved surface of the primary shell 3 in stages until all excess material on the side curved surface of the primary shell 3 is completely removed.

[0092] In this embodiment, a magnet 13 is embedded in the bottom of the base 1. The magnet 13 is used to adsorb and fix the base 1 in the cavity of the pressing mold, the primary shaping mold or the finished product shaping mold.

[0093] The following takes the original plate 2 as a nickel-titanium shape memory alloy plate as an example to specifically describe the working principle and use process of the left atrial appendage occluder skeleton manufacturing system of this embodiment:

[0094] First, the original plate 2 with roughly calculated dimensions is cut, pressed, and laid on the base 1. The dimensions of the original plate 2 should be sufficient to basically completely wrap the base 1.

[0095] Then, if Figure 3 and Figure 4As shown, the magnet 13 is installed in the concave hole opened at the bottom of the base 1, and the base 1 after the magnet 13 is installed is placed in the cavity of the lower pressing mold 4. The base 1 is fixed in the cavity of the lower pressing mold 4 by the adsorption effect of the magnet 13 on the metal lower pressing mold 4; then the upper pressing mold 5 is driven to move downward to close the mold with the lower pressing mold 4. During the closing process, the upper pressing mold 5 presses the upper part of the original plate 2 into shape, and the upper pressing mold 5 presses the lower part of the original plate 2 into shape, and finally the primary shell 3 is obtained by pressing.

[0096] Then, if Figure 5 and Figure 6 As shown, the primary housing 3 remains attached to the base 1 after the pressing phase. The upper and lower primary shaping molds 7 and 6 seal the base 1 encased in the primary housing 3 for heat treatment and memory shaping. Magnets 13 attach the base 1 encased in the primary housing 3 to the lower primary shaping mold 6, preventing it from moving relative to the mold cavity during shaping. The lower primary shaping mold 6 is a magnetically attracted metal mold, so magnets 13 can attract it.

[0097] Then, the primary shell 3 after primary shaping, i.e. the preliminary shaping shell, is subjected to material removal. Figure 8 As shown, the magnet 13 sucks the base 1 with the preliminary shaped shell into the cavity of the pressing die 4 for fixation. The preliminary shaped shell is not removed from the base 1 after the preliminary heat treatment memory shaping stage is completed, and is still sleeved on the base 1. The pressing die 4 is installed on the workbench of the machine tool, and the EDM conductive electrode 10 is installed on the main shaft of the machine tool. The direction of the dotted arrow is the electrode servo feeding direction. The EDM conductive electrode 10 is fed along the dotted arrow direction to remove the excess material on the upper part of the preliminary shaped shell, and finally a mesh shell semi-finished product 12 is made. The dotted structure part is a schematic diagram of the internal structure of the EDM conductive electrode 10. The protruding part is used for discharge etching to remove the excess material of the preliminary shaped shell. Then as Figure 9As shown, the base 1 with the mesh shell semi-finished product 12 is installed on the mounting base 15, the mounting base 15 is installed on the workbench of the machine tool, the EDM conductive electrode 11 is installed on the spindle of the machine tool, the direction of the dotted arrow is the electrode servo feed direction, the fastening cover 16 has a certain elasticity and is installed on the mesh shell semi-finished product 12 to ensure that the mesh shell semi-finished product 12 and the base 1 do not rotate relative to each other. The EDM conductive electrode 2 11 has multiple sides that can be used for processing. The excess material on the side of the mesh shell semi-finished product 12 is removed by repeated EDM processing. In the single-petal processing, the EDM conductive electrode 2 11 is servo-fed along the direction of the dotted arrow to form a mesh shell semi-finished product 2 14. After completing the single-petal processing, the machine tool turntable rotates to drive the mounting base plate 15 to rotate to the next processing position to repeat the single-petal processing. When the processing part of one side of the EDM conductive electrode 2 11 is severely worn, the processing surface of the EDM conductive electrode 2 11 can be switched by rotating the machine tool servo spindle. Finally, all the excess material on the side of the mesh shell semi-finished product 12 is removed, and the mesh skeleton semi-finished product 8 with barbed bending material reserved is processed.

[0098] Then, if Figure 10 As shown, the dotted box on the left is a partial enlargement of the bending process of a single barb, and the dotted box on the right is the mesh skeleton semi-finished product 8 produced in the previous step, which is sleeved on the base 1. For each barb, after the bending fixed rod 18 is positioned to the specified position, the bending movable rod 19 drives the barb bending material to bend it into an arc-shaped barb 901 along the motion trajectory in the direction of the dotted arrow, until all the barb bending materials are bent to form barbs 901, finally forming a mesh skeleton semi-finished product 17 with hooks.

[0099] Then, if Figure 11 and Figure 12As shown, it is a schematic diagram of the positional relationship between the various parts of the hook mesh skeleton semi-finished product 17 during the heat treatment memory shaping stage. The dotted box on the left is a partial enlargement of the positional relationship between a single barb 901 and the finished product shaping mold. The magnet 13 sucks the base 1 with the hook mesh skeleton semi-finished product 17 onto the finished product shaping lower mold 22. The outer side of the barb 901 of the hook mesh skeleton semi-finished product 17 can just be stuck on the annular groove 2201 of the finished product shaping lower mold 22. The finished product shaping middle mold 21 is installed on the finished product. On the finalizing lower mold 22, the inner side of the barb 901 of the semi-finished product 17 of the hook mesh skeleton is just stuck on the annular boss 2101 of the finished product finalizing middle mold 21, that is, the annular boss 2101 and the annular groove 2201 constrain the barb 901 between the two. The finished product finalizing upper mold 20 is installed on the finished product finalizing middle mold 21. The three molds are constrained in position by two positioning pins 23 and fixedly connected by multiple sets of nuts 24 and bolts 25 to ensure that the finished product finalizing process is reliable. After the finished product finalizing is completed, the finished product finalizing upper mold 20, the finished product finalizing middle mold 21 and the finished product finalizing lower mold 22 are removed, and the finished product 9 of the hook mesh skeleton formed after the finalizing of the finished product is removed from the base 1. After cleaning and decontamination, the preparation process of the finished product 9 of the hook mesh skeleton is completed.

[0100] From the above, it can be seen that the structure and use process of the left atrial appendage occluder skeleton manufacturing system proposed in this embodiment have significant improvements: the precise estimation of the raw materials can be avoided by preliminary cutting and pressing the original plate material, and the primary shell pressed by the lower pressing mold and the upper pressing mold is subjected to preliminary heat treatment and shaping by the lower primary shaping mold and the upper primary shaping mold, thereby reducing the probability of deformation of the primary shell during processing to ensure processing accuracy. By using the first and second conductive electrodes formed by electrospark forming, the excess material on the upper half surface and side of the preliminary shaped shell is removed respectively by using the non-contact processing method of electrospark forming processing, and then the barbs are prepared by the bending fixed round rod and the bending movable round rod of the barb bending mechanism to realize the one-piece forming processing of the hook mesh skeleton semi-finished product. The matching use of the above-mentioned molds can accurately control the shape of the one-piece formed left atrial appendage occluder hook mesh skeleton finished product, ensure the quality and accuracy of the left atrial appendage occluder hook mesh skeleton finished product, and can effectively avoid the problems of easy cracking and fatigue fracture failure of the skeleton caused by connection methods such as welding, gluing, and weaving. At the same time, it has better versatility and higher feasibility in meeting different skeleton manufacturing requirements.

[0101] It should be noted that it is obvious to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention. Therefore, from all perspectives, the embodiments should be regarded as illustrative and non-restrictive, and the scope of the present invention is defined by the appended claims rather than the foregoing description. It is intended that all changes that fall within the meaning and range of equivalents of the claims be included in the present invention, and any reference signs in the claims should not be construed as limiting the claims to which they relate.

[0102] The present invention uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only intended to help understand the method and core concept of the present invention. At the same time, those skilled in the art will find that the specific implementation methods and application scopes may vary based on the concept of the present invention. In summary, the contents of this specification should not be construed as limiting the present invention.

Claims

1. A method for manufacturing a left atrial appendage occluder skeleton, characterized in that: include: According to the outline of the finished mesh skeleton with hooks, a mesh skeleton semi-finished product model and a surface insulating base that are compatible with its shape and size are designed and manufactured; Designing and manufacturing a pressing mold, a primary shaping mold, a finished product shaping mold, and an electrospark forming conductive electrode based on the predicted model of the substrate and the mesh skeleton semi-finished product, wherein the cavities of the pressing mold, the primary shaping mold, and the finished product shaping mold are all adapted to the outer contour of the substrate, and the processing portion of the electrospark forming conductive electrode is adapted to the outer contour of the substrate; Pressing the original plate into a primary shell having the initial shape of the left atrial appendage occluder skeleton by the pressing die and the base; Preliminary shaping of the primary shell is performed using the primary shaping mold and the base to form a preliminarily shaped shell; The excess material on the outer peripheral curved surface of the preliminarily formed shell is removed by electrospark machining using the electrospark forming conductive electrode to produce a mesh skeleton semi-finished product with a barb forming portion reserved; The barb-forming portion reserved on the mesh frame semi-finished product is bent into barbs to produce a mesh frame semi-finished product with hooks; The finished product shaping mold and the base are used to shape the semi-finished product of the mesh frame with hooks into a finished product to produce the finished product of the mesh frame with hooks.

2. The method for manufacturing a left atrial appendage occluder skeleton according to claim 1, wherein: The electrospark forming conductive electrode is designed and manufactured based on the reverse copy processing technology.

3. The method for manufacturing a left atrial appendage occluder skeleton according to claim 1 or 2, wherein: After the electrospark forming conductive electrode is manufactured, it is further divided into an electrospark forming conductive electrode 1 adapted to the top contour of the primary shell and an electrospark forming conductive electrode 2 adapted to the side contour of the primary shell; The semi-finished product of the mesh skeleton with the barb-shaped portion reserved therefor comprises: The excess material on the top curved surface of the primary shell is removed by electrospark machining using the electrospark forming conductive electrode 1 to form a mesh shell semi-finished product 1; The excess material on the curved surface of one side of the mesh shell semi-finished product is removed by electrospark machining using the second electrospark forming conductive electrode to form a second mesh shell semi-finished product; All excess materials on the two side curved surfaces of the mesh shell semi-finished product are removed by electrospark machining in batches to produce the mesh skeleton semi-finished product.

4. The method for manufacturing a left atrial appendage occluder skeleton according to claim 1 or 2, wherein: The substrate is made of ceramic; or the substrate is made of metal or non-metal, and then a non-conductive coating is coated on the surface.

5. The method for manufacturing a left atrial appendage occluder skeleton according to claim 1 or 2, wherein: The original plate is a nickel-titanium memory alloy plate that is cut and pressed according to the material size required by the primary shell; the preliminary shaping and the finished product shaping are both performed by heat treatment technology for memory shaping.

6. A left atrial appendage occluder skeleton manufacturing system, characterized in that: It comprises a barb bending mechanism and a base body, a pressing mold, a primary shaping mold, a finished product shaping mold and an electrospark forming conductive electrode made based on the left atrial appendage occluder skeleton manufacturing method according to any one of claims 1 to 5, wherein the pressing mold and the base body cooperate to form a primary shell having the initial form of the left atrial appendage occluder skeleton; the primary shaping mold and the base body cooperate to perform preliminary shaping on the primary shell to make a preliminary shaped shell; the electrospark forming conductive electrode is used to remove excess material on the outer peripheral curved surface of the preliminary shaped shell to make a mesh skeleton semi-finished product with a reserved barb forming part; the barb bending mechanism is used to bend the barb forming part to make a hooked mesh skeleton semi-finished product; the finished product shaping mold and the base body cooperate to perform finished shaping on the hooked mesh skeleton semi-finished product to make the hooked mesh skeleton finished product.

7. The left atrial appendage occluder skeleton manufacturing system according to claim 6, characterized in that: The pressing die includes an upper pressing die and a lower pressing die; the primary shaping die includes an upper primary shaping die and a lower primary shaping die; the finished product shaping die includes bolts and a finished product shaping upper die, a finished product shaping middle die, and a finished product shaping lower die arranged in sequence from top to bottom, the bolts being used to connect and fasten the finished product shaping upper die, the finished product shaping middle die, and the finished product shaping lower die when the finished product shaping die performs finished shaping on the semi-finished product of the mesh skeleton with hooks; The inner walls of the mold cavities of the upper pressure mold, the lower pressure mold, the upper primary shaping mold, the lower primary shaping mold, the finished product shaping upper mold, the finished product shaping middle mold and the finished product shaping lower mold are all provided with flow channels for circulation of hot air flow, and the flow channels include a number of auxiliary air flow channels distributed according to the grid patterns of the finished product of the hooked mesh skeleton, and all the auxiliary air flow channels of any one of the upper pressure mold, the upper primary shaping mold and the finished product shaping upper mold converge at one point at the top of the corresponding mold to form a main air flow channel.

8. The left atrial appendage occluder skeleton manufacturing system according to claim 7, characterized in that: The barb bending mechanism includes a bending fixed circular rod for being arranged in contact with one side of the barb forming portion and a bending movable circular rod for being arranged in contact with the other side of the barb forming portion, and driving the bending movable circular rod to roll along the circumference of the bending fixed circular rod to bend the barb forming portion into an upwardly curled arc barb; The lower edge of the cavity of the finished product shaping middle mold is provided with an annular boss adapted to the inner circular surface of the arc barb, and the upper edge of the cavity of the finished product shaping lower mold is provided with an annular groove adapted to the outer circular surface of the arc barb.

9. The left atrial appendage occluder skeleton manufacturing system according to claim 6, characterized in that: The electrospark forming conductive electrode includes an electrospark forming conductive electrode 1 and an electrospark forming conductive electrode 2. The electrospark forming conductive electrode 1 is used to perform electrospark machining to remove excess material on the top curved surface of the primary shell, and the electrospark forming conductive electrode 2 is used to perform electrospark machining to remove excess material on the side curved surface of the primary shell.

10. The left atrial appendage occluder skeleton manufacturing system according to any one of claims 6 to 9, characterized in that: A magnet is embedded in the bottom of the base, and the magnet is used to adsorb and fix the base in the cavity of the pressing mold, the primary shaping mold or the finished product shaping mold.

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