An environmentally friendly shaping and skin-beautifying aerosol and its preparation method
This environmentally friendly shaping and skin-beautifying aerosol, formulated with a blend of cellulose, emulsifiers, elastomer gel, methylxanthine mixture, and propellant, solves the problems of insignificant effects and insufficient skin firmness found in existing weight loss products, providing a safe, comfortable user experience and visual appeal.
Patent Information
- Application Number
- CN202211368820.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-11-03
- Publication Date
- 2025-10-31
- Estimated Expiration
- 2042-11-03
AI Technical Summary
Existing weight loss products are not very effective in the weight loss process, do not provide enough skin tightening, and have toxic side effects, resulting in a poor user experience.
An environmentally friendly shaping and skin-beautifying aerosol is formed by combining cellulose blended with hydroxyethyl cellulose and hydroxypropyl methyl cellulose, emulsifier blended with Tween-20 and cholesterol polyether-24, high-purity elastomer gel, active ingredients blended with methyl xanthine mixture, artichoke extract and fructan, emollient blended with dodecyl lactate and lactic acid polyester, solvent of trans-1-chloro-3,3,3-trifluoropropylene and propellant of tetrafluoropropylene.
It achieves significant shaping and skin firming effects, enhances the user experience, reduces adverse reactions, has a cooling and bouncy feel, is suitable for sensitive skin, and is safe and environmentally friendly.
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Abstract
Description
Technical Field
[0001] This invention relates to the field of C09D201 / 00, and specifically to an environmentally friendly shaping and skin-beautifying aerosol and its preparation method. Background Technology
[0002] Obesity is an energy metabolism disorder characterized by an increase in the number or size of fat cells in the body, leading to a significant increase in body fat. It is a disease caused by the excessive storage of energy in the body due to the interaction of multiple factors, including genes, environment, behavior (resting lifestyle), society (dietary structure), economy, and culture.
[0003] CN1368078A discloses a nano-weight-loss preparation, which is made from nano-rhubarb, nano-fangji, nano-danshen, nano-yinchen, nano-zelia, nano-hawthorn, nano-buffalo horn, nano-epithelial foetida, nano-astragalus, nano-atractylodes macrocephala, and nano-chuanxiong as raw materials, using microwave extraction, vacuum concentration, and supersonic jet spray drying. However, the therapeutic effect is not significant and the use is inconvenient.
[0004] CN110123843A provides a composition for weight loss and lipid reduction and its application, comprising berberine hydrochloride and a lipid-soluble extract of sea squirt, obtained by extracting the filtrate with n-butanol and concentrating it, which has significant effects on reducing weight and regulating blood lipids, but the user experience needs to be improved.
[0005] Furthermore, the aforementioned products do not have a skin-tightening effect. If one loses weight rapidly, the skin will not become firm, and stretch marks that affect appearance will appear. In response to the above problems, there is an urgent need in this field to develop a non-toxic, safe, environmentally friendly, and highly effective shaping and skin-beautifying product with excellent user experience. Summary of the Invention
[0006] To address the aforementioned problems, this invention discloses an environmentally friendly shaping and skin-beautifying aerosol. By weight, the raw materials for preparing the aerosol include 20-25 parts of functional components, 8-10 parts of solvent, 60-70 parts of propellant, and 0.01-0.2 parts of fragrance.
[0007] Preferably, the raw materials for preparing the aerosol include 22.92 parts by weight, 9 parts by weight, 68 parts by weight, and 0.08 parts by weight, of functional components, solvent, propellant, and fragrance.
[0008] In one embodiment, the functional components, by weight, include 1-3 parts cellulose, 0.5-2 parts moisturizer, 2-6 parts emulsifier, 3-5 parts skin conditioning agent, 2-5 parts active ingredient, 0.5-2 parts emollient, 0.1-0.5 parts preservative, 10-20 parts ethanol, and 60-80 parts water.
[0009] Preferably, the functional components include 1.8 parts cellulose, 0.8 parts moisturizer, 3 parts emulsifier, 4 parts skin conditioning agent, 3 parts active ingredient, 1 part emollient, 0.4 parts preservative, 19 parts ethanol, and 67 parts water.
[0010] The raw materials and functional components used in the preparation of aerosols have different mass content standards.
[0011] In one embodiment, the cellulose is selected from one or more of hydroxymethyl cellulose, hydroxyethyl cellulose, and hydroxypropyl methyl cellulose.
[0012] Preferably, the cellulose is a blend of hydroxyethyl cellulose and hydroxypropyl methyl cellulose in a mass ratio of (0.5-1):1.
[0013] More preferably, the mass ratio of hydroxyethyl cellulose to hydroxypropyl methyl cellulose is 0.8:1.
[0014] In one embodiment, the moisturizer is selected from one or more of propylene glycol, dipropylene glycol, glycerin, hyaluronic acid, polyethylene glycol, and sorbitol.
[0015] Preferably, the humectant is propylene glycol.
[0016] In one embodiment, the emulsifier is selected from one or more of Tween-20, cholesterol polyether-24, Tween-85, peanut alcohol, agarol polyether-2, agarol polyether-21, oleyl alcohol polyether-2, and polyglycerol-6-dioleate.
[0017] Preferably, the emulsifier is a mixture of Tween-20 and cholesterol polyether-24 in a mass ratio of 1:(2-10).
[0018] More preferably, the mass ratio of Tween-20 to cholesterol polyether-24 is 1:4.
[0019] In one embodiment, the skin conditioning agent is a high-purity elastomeric gel purchased from Kobo Products, Inc., under the brand name Care Sil. TM CES-1104.
[0020] The high-purity elastomer gel selected in this invention can be directly added to the aqueous phase or added later to the emulsion in the form of a hydrophilic hydrogel. The emulsion is stabilized by a silicone film formed by surfactant-free organosilicon, giving the user a fresh, velvety soft feeling.
[0021] In one embodiment, the active ingredient is selected from one or more of the following: a mixture of methylxanthines, artichoke extract, fructan, Garcinia cambogia extract, mulberry leaf extract, winter melon pulp extract, bitter melon extract, and lycopene.
[0022] Preferably, the active ingredient is a mixture of methylxanthine, artichoke extract, and fructan, in a mass ratio of (2-4):1:2.
[0023] More preferably, the mass ratio of the mixture of methylxanthine, artichoke extract, and fructan is 3:1:2.
[0024] Preferably, the mixture of methylxanthines is a combination of 3,7-dimethyl-xanthine, 1,7-dimethyl-xanthine, 7-methyl-xanthine, and 1,3,7-trimethyl-xanthine in a mass ratio of (0.5-2):(0.5-1):(0.5-0.8):2.
[0025] More preferably, the mass ratio of 3,7-dimethyl-xanthine, 1,7-dimethyl-xanthine, 7-methyl-xanthine, and 1,3,7-trimethyl-xanthine is 1:1:0.5:2.
[0026] The efficacy of methylxanthine has been documented and proven in the literature. However, during experiments, the inventors found that its shaping effect was not ideal and the effect was slow. Through extensive experimentation, the inventors creatively discovered that using a mixture of four different methylxanthines, combined with artichoke extract and fructan, significantly improved the shaping effect. The inventors believe this is likely because 3,7-dimethylxanthine, commonly known as theobromine, and 1,3,7-trimethylxanthine, commonly known as caffeine, have proven effective in shaping. Excessive intake of these two components may cause gastrointestinal dysfunction, palpitations, drowsiness, and high blood pressure. To prevent adverse reactions, this invention controls the quality of the added components, ensuring no adverse reactions during use. However, this also means that the effectiveness of the added components is crucial. Caffeine has two metabolic pathways in the human body: the primary metabolism is caffeine → theophylline and 3-methylxanthine, and the secondary metabolism is caffeine → 1,7-dimethylxanthine → 7-methylxanthine. By adding small amounts of 1,7-dimethylxanthine and 7-methylxanthine, the inventors further improve the efficiency of caffeine's primary metabolism, resulting in a shaping effect three times that of adding only 3,7-dimethylxanthine (commonly known as 1,3,7-trimethylxanthine). The extremely small amount of added components achieves the best results.
[0027] Furthermore, the synergistic effect of the mixture of artichoke extract and methylxanthine further promotes fat breakdown. Artichoke extract can stimulate bile secretion, increasing the consumption and clearance of fat in the blood. Fructan can inhibit fat synthesis and activate fat breakdown in the liver. The mixture of methylxanthine has the effect of preventing the production of new fat cells, reducing fat storage, and promoting decomposition. The three substances work together to block fat cells from the entire pathway of fat generation to fat breakdown. In addition, the mixture of artichoke extract and methylxanthine can promote blood circulation, reduce tissue swelling, eliminate edema, and further enhance visual aesthetics, achieving a dual effect of internal and visual shaping. Moreover, the above process also makes fructan easier for the human body to absorb, thereby moisturizing, soothing skin allergies, and promoting skin firmness. This makes this product not only shaping but also beautifying.
[0028] In one embodiment, the softener is a blend of dodecyl lactate (and) polyester lactate (and) hexadecyl lactate, purchased from Ashland under the brand name Ceraphyl. TM 31 ester.
[0029] The addition of the above-mentioned emulsifier in this invention can reduce the stickiness and greasiness of the product, give the water-alcohol system product non-oil-based lubrication, make it easy to emulsify, produce creamy foam, and provide an excellent user experience.
[0030] In one embodiment, the preservative is selected from any one of benzyl alcohol, benzoic acid, salicylic acid, boric acid, sorbic acid, phenoxyethanol, and ethylhexylglycerin composite preservatives.
[0031] Preferably, the preservative is a compound preservative of phenoxyethanol and ethylhexylglycerin, purchased from Ashland, brand name euxy. TM pe 9010 preservative.
[0032] In one embodiment, the solvent includes, but is not limited to, ethanol, 1-chloro-3,3,3-trifluoropropene, n-butanol, isopropanol, and butyl lactate.
[0033] Preferably, the solvent is 1-chloro-3,3,3-trifluoropropylene.
[0034] More preferably, the 1-chloro-3,3,3-trifluoropropene is trans-1-chloro-3,3,3-trifluoropropene, purchased from Honeywell under the brand name Solstice Enhance.
[0035] The trans-1-chloro-3,3,3-trifluoropropylene selected in this invention possesses superior properties such as low toxicity, low GWP, zero ODP, and non-flammability. Using trans-1-chloro-3,3,3-trifluoropropylene as the solvent brings numerous sensory benefits to the product. An excellent product should not only possess superior efficacy but also emphasize user experience. The formulation of this invention, with the compound solvent trans-1-chloro-3,3,3-trifluoropropylene, generates dense bubbles upon application. These bubbles, upon contact with the skin, provide a cooling sensation, instantly lowering skin temperature. Furthermore, the dense bubbles are rapidly absorbed after being sprayed onto the skin, accompanied by a crackling sound. After exercise, this product brings consumers a sense of mental pleasure, is highly stress-relieving, and provides an excellent user experience.
[0036] In one embodiment, the propellant is selected from any one of propane, n-butane, isobutane, dimethyl ether, tetrafluoroethane, and tetrafluoropropylene.
[0037] Preferably, the propellant is tetrafluoropropylene, purchased from Honeywell, brand name SolsticePropellant.
[0038] Currently, the most commonly used propellants are propane and butane, both of which are highly hazardous materials and are very prone to explosion under high temperature or high pressure. Therefore, the use of such materials is strictly restricted in transportation vehicles such as airplanes, trains, and subways. The tetrafluoropropylene used in this invention can reduce the danger of aerosol products. Compared to propane and butane, tetrafluoropropylene has lower toxicity, higher fire safety, and a milder odor, resulting in a better user experience when used in aerosols.
[0039] In one embodiment, the fragrance includes, but is not limited to, lavender fragrance, jasmine fragrance, rose fragrance, and gardenia fragrance, which can be selected by those skilled in the art according to actual needs.
[0040] Another aspect of the present invention discloses a method for preparing the aerosol, comprising the following steps:
[0041] (1) The functional components are mixed with fragrance and solvent to obtain liquid 1;
[0042] (2) Pack the liquid material 1 and the propellant into aerosol cans according to the mass ratio, and the test is qualified.
[0043] The environmentally friendly shaping and skin-beautifying product of this invention is packaged in an aerosol can, resulting in better sealing. Therefore, the active ingredients in the aerosol are well-sealed and more stable, preventing deactivation. Only a small amount of preservative is needed to ensure the product's efficacy and shelf life, making it suitable even for people with sensitive skin. This product is for single use only and will not be refilled, eliminating the risk of contamination from external air or other pollutants. The product is sprayed through a single nozzle, avoiding the shrinkage phenomenon found in ordinary packaging, thus fully guaranteeing the quality of the contents and preventing contamination. It is portable and can be sprayed whenever needed, even in damp, bacteria-prone places like bathrooms, ensuring it remains unspoiled. Furthermore, the wide mist angle allows for continuous spraying at any angle, producing a light, soft mist with fine atomization, creating a refreshing, popping sensation on the skin.
[0044] Beneficial effects:
[0045] 1. This invention incorporates high-purity elastomeric gel, giving users a refreshing, velvety soft feel.
[0046] 2. This invention uses a mixture of four different methylxanthines, and combines them with artichoke extract and fructan, which greatly improves the shaping effect and has no adverse reactions during use.
[0047] 3. This invention utilizes the synergistic effect of a mixture of artichoke extract and methylxanthine to promote blood circulation, reduce tissue swelling, eliminate edema, and further enhance visual appeal, achieving a dual effect of internal and visual shaping. Furthermore, it makes fructan more easily absorbed by the human body, thereby moisturizing, soothing skin allergies, and promoting skin firmness. This makes the product not only shaping but also skin-beautifying.
[0048] 4. The present invention adds a blend of dodecyl lactate (and) polyester lactate (and) hexadecyl lactate as a softener, which reduces the stickiness and greasiness of the product, gives the water-alcohol system product non-oil-like lubrication, makes it easy to emulsify, brings creamy foam, and provides an excellent user experience.
[0049] 5. The trans-1-chloro-3,3,3-trifluoropropylene selected in this invention has superior properties such as low toxicity, low GWP, zero ODP, and non-flammability. It is safe and environmentally friendly. When used, it can generate dense bubbles. When these bubbles come into contact with the skin, they have a cooling sensation and instantly cool the skin. Furthermore, the dense bubbles are quickly absorbed after being sprayed on the skin, accompanied by a crackling sound. After exercise, this product can bring consumers a sense of mental pleasure, relieve stress, and provide an excellent user experience.
[0050] 6. Compared with commonly used propellants such as propane and butane, the tetrafluoropropylene of this invention has lower toxicity, higher fire safety, and a milder odor, resulting in a better user experience when used in aerosols.
[0051] 7. The environmentally friendly shaping and skin-beautifying product described in this invention is filled into an aerosol can, which has better sealing properties. Only a small amount of preservative needs to be added to ensure the efficacy and shelf life of the product. This product is suitable for people with sensitive skin.
[0052] 8. This product can be carried around and sprayed whenever you want. It can also be placed anywhere, and even in damp places such as bathrooms where bacteria can easily grow, it will not deteriorate or become ineffective.
[0053] 9. When in use, the mist angle is wide, allowing for continuous spraying at any angle. The mist particles are light and soft, and the atomization is delicate, allowing the cool little bubbles to pop and crackle on the skin, creating a dancing sensation. Attached Figure Description
[0054] Figure 1 Microscopic image of preadipocytes 3T3-L1
[0055] Figure 2 Microscopic observation of preadipocyte morphology and lipid accumulation
[0056] Figure 3 Comparison of edema area reduction before and after test
[0057] Figure 4 Comparison of thinning at the dermal-subcutaneous junction before and after testing Detailed Implementation
[0058] Hydroxyethyl cellulose was purchased from Guangzhou Ars New Materials Co., Ltd., model number HHR250.
[0059] Hydroxypropyl methylcellulose was purchased from Guangzhou Huazhiwang Chemical Co., Ltd., CAS: 9004-65-3.
[0060] Tween-20 was purchased from Guangdong Riyou Technology Co., Ltd., and its brand name is Tween-20.
[0061] Artichoke extract was purchased from Henan Yixin Biotechnology Co., Ltd., product number: YX-005307.
[0062] The remaining undisclosed components are all commercially available.
[0063] Example 1
[0064] This embodiment 1 discloses an environmentally friendly shaping and skin-beautifying aerosol. By weight, the raw materials for preparing the aerosol are 20 parts of functional components, 10 parts of solvent, 60 parts of propellant, and 0.01 parts of fragrance.
[0065] By weight, the functional components are 1 part cellulose, 0.5 part propylene glycol, 2 parts emulsifier, 5 parts skin conditioning agent, 5 parts active ingredient, 2 parts emollient, 0.1 part preservative, 10 parts ethanol, and 60 parts water.
[0066] The raw materials and functional components used in the preparation of aerosols have different mass content standards.
[0067] The cellulose is a blend of hydroxyethyl cellulose and hydroxypropyl methyl cellulose in a mass ratio of 0.5:1.
[0068] The emulsifier is a mixture of Tween-20 and cholesterol polyether-24 in a mass ratio of 1:2.
[0069] The skin conditioning agent is a high-purity elastomeric gel purchased from Kobo Products, Inc., under the brand name CareSil. TM CES-1104.
[0070] The active ingredients are a mixture of methylxanthine, artichoke extract, and fructan, in a mass ratio of 2:1:2.
[0071] The mixture of methylxanthines is a combination of 3,7-dimethyl-xanthine, 1,7-dimethyl-xanthine, 7-methyl-xanthine, and 1,3,7-trimethyl-xanthine in a mass ratio of 0.5:0.5:0.8:2.
[0072] The softener is a compound of dodecyl lactate (and), polyester lactate (and), and hexadecyl lactate, purchased from Ashland under the brand name Ceraphyl. TM 31 ester.
[0073] The preservative is a compound preservative of phenoxyethanol and ethylhexylglycerin, purchased from Ashland, brand name euxy. TM pe 9010 preservative.
[0074] The solvent is trans-1-chloro-3,3,3-trifluoropropylene, purchased from Honeywell under the brand name SolsticeEnhance.
[0075] The propellant is tetrafluoropropylene, purchased from Honeywell under the brand name Solstice Propellant.
[0076] This embodiment 1 also discloses a method for preparing the aerosol, the steps of which are as follows:
[0077] (1) The functional components are mixed with fragrance and solvent to obtain liquid 1;
[0078] (2) Pack the liquid material 1 and the propellant into aerosol cans according to the mass ratio, and the test is qualified.
[0079] Example 2
[0080] This embodiment 2 discloses an environmentally friendly shaping and skin-beautifying aerosol. By weight, the raw materials for preparing the aerosol are 25 parts of functional components, 8 parts of solvent, 70 parts of propellant, and 0.2 parts of fragrance.
[0081] By weight, the functional components are 3 parts cellulose, 2 parts propylene glycol, 6 parts emulsifier, 3-5 parts skin conditioning agent, 2 parts active ingredient, 0.5 parts emollient, 0.5 parts preservative, 20 parts ethanol, and 80 parts water.
[0082] The raw materials and functional components used in the preparation of aerosols have different mass content standards.
[0083] The cellulose is a blend of hydroxyethyl cellulose and hydroxypropyl methyl cellulose in a mass ratio of 1:1.
[0084] The emulsifier is a mixture of Tween-20 and cholesterol polyether-24 in a mass ratio of 1:10.
[0085] The skin conditioning agent is a high-purity elastomeric gel purchased from Kobo Products, Inc., under the brand name CareSil. TM CES-1104.
[0086] The active ingredients are a mixture of methylxanthine, artichoke extract, and fructan, in a mass ratio of 4:1:2.
[0087] The mixture of methylxanthines is a combination of 3,7-dimethyl-xanthine, 1,7-dimethyl-xanthine, 7-methyl-xanthine, and 1,3,7-trimethyl-xanthine in a mass ratio of 2:1:0.5:2.
[0088] The softener is a compound of dodecyl lactate (and), polyester lactate (and), and hexadecyl lactate, purchased from Ashland under the brand name Ceraphyl. TM 31 ester.
[0089] The preservative is a compound preservative of phenoxyethanol and ethylhexylglycerin, purchased from Ashland, brand name euxy. TM pe 9010 preservative.
[0090] The solvent is trans-1-chloro-3,3,3-trifluoropropylene, purchased from Honeywell under the brand name SolsticeEnhance.
[0091] The propellant is tetrafluoropropylene, purchased from Honeywell under the brand name Solstice Propellant.
[0092] This embodiment 2 also discloses a method for preparing the aerosol, the steps of which are as follows:
[0093] (1) The functional components are mixed with fragrance and solvent to obtain liquid 1;
[0094] (2) Pack the liquid material 1 and the propellant into aerosol cans according to the mass ratio, and the test is qualified.
[0095] Example 3
[0096] This embodiment 3 discloses an environmentally friendly shaping and skin-beautifying aerosol. By mass, the raw materials for preparing the aerosol are 22.92 parts of functional components, 9 parts of solvent, 68 parts of propellant, and 0.08 parts of fragrance.
[0097] By weight, the functional components include 1.8 parts cellulose, 0.8 parts moisturizer, 3 parts emulsifier, 4 parts skin conditioning agent, 3 parts active ingredient, 1 part emollient, 0.4 parts preservative, 19 parts ethanol, and 67 parts water.
[0098] The raw materials and functional components used in the preparation of aerosols have different mass content standards.
[0099] The cellulose is composed of hydroxyethyl cellulose and hydroxypropyl methyl cellulose in a mass ratio of 0.8:1.
[0100] The emulsifier is Tween-20 and cholesterol polyether-24 in a mass ratio of 1:4.
[0101] The skin conditioning agent is a high-purity elastomeric gel purchased from Kobo Products, Inc., under the brand name CareSil. TM CES-1104.
[0102] The active ingredients are a mixture of methylxanthine, artichoke extract, and fructan, in a mass ratio of 3:1:2.
[0103] The mixture of methylxanthines is a combination of 3,7-dimethyl-xanthine, 1,7-dimethyl-xanthine, 7-methyl-xanthine, and 1,3,7-trimethyl-xanthine in a mass ratio of 1:1:0.5:2.
[0104] The softener is a compound of dodecyl lactate (and), polyester lactate (and), and hexadecyl lactate, purchased from Ashland under the brand name Ceraphyl. TM 31 ester.
[0105] The preservative is a compound preservative of phenoxyethanol and ethylhexylglycerin, purchased from Ashland, brand name euxy. TM pe 9010 preservative.
[0106] The solvent is trans-1-chloro-3,3,3-trifluoropropylene, purchased from Honeywell under the brand name SolsticeEnhance.
[0107] The propellant is tetrafluoropropylene, purchased from Honeywell under the brand name Solstice Propellant.
[0108] This embodiment 3 discloses another aspect of the preparation method of the aerosol, the steps of which are as follows:
[0109] (1) The functional components are mixed with fragrance and solvent to obtain liquid 1;
[0110] (2) Pack the liquid material 1 and the propellant into aerosol cans according to the mass ratio, and the test is qualified.
[0111] Comparative Example 1
[0112] The difference between Comparative Example 1 and Example 3 is that the methylxanthine is 1,3,7-trimethyl-xanthine.
[0113] Comparative Example 2
[0114] The difference between Comparative Example 2 and Example 3 is that trans-1-chloro-3,3,3-trifluoropropene is replaced with ethanol, and the softener is dodecyl lactate.
[0115] Comparative Example 3
[0116] The difference between Comparative Example 3 and Example 3 is that the propellant is replaced with propane.
[0117] Performance testing
[0118] 1. User experience test: The products obtained in Examples 1-3 and Comparative Examples 1-3 were tested. Evaluation indicators: A: Multi-angle spray is normal, the product has a crackling sound, is cool, cools down quickly, the foam disappears quickly, the user experience is good, and there is no irritating odor; B: Partial angle spray is normal, has a cooling effect, the foam disappears slowly, there is no sound or the sound is very low, the user experience is poor, and there is an irritating odor.
[0119]
[0120] 2. In vitro experiments: Experimental subjects were preadipocytes 3T3-L1, such as... Figure 1In the cell differentiation experiment, culture medium 1 served as a blank control group, containing no components; culture medium 2 consisted of a mixture of 0.005% methylxanthine, specifically a combination of 3,7-dimethylxanthine, 1,7-dimethylxanthine, 7-methylxanthine, and 1,3,7-trimethylxanthine in a mass ratio of 1:1:0.5:2; and culture medium 3 contained 0.01% 1,3,7-trimethylxanthine. After 6 days of culture, the morphology of preadipocytes and lipid accumulation were observed under a microscope. The results are as follows: Figure 2 It can be seen that the efficacy of the mixture of methylxanthine is significantly better than that of 1,3,7-trimethyl-xanthine.
[0121] 3. In vivo experiment: 20 healthy subjects with obvious cellulite, aged 18-65 years (mean 40.5 years), were included. Ten subjects were randomly assigned to Example 3, and ten to Comparative Example 1. The treatment lasted 84 days, twice daily. A 20MHz ultrasound scan was used to measure the edema area, dermal structure, and density before and after treatment. Results are as follows: Figure 3 , Figure 4 It is evident that Example 3 is significantly better than Comparative Example 1.
Claims
1. An environmentally friendly shaping and skin-beautifying aerosol, characterized in that, The aerosol preparation raw materials, by weight, consist of the following components: 20-25 parts functional components, 60-70 parts propellant, 8-10 parts solvent, and 0.01-0.2 parts fragrance; The functional components consist of the following ingredients: 1-3 parts cellulose, 0.5-2 parts moisturizer, 2-6 parts emulsifier, 3-5 parts skin conditioning agent, 2-5 parts active ingredient, 0.5-2 parts emollient, 0.1-0.5 parts preservative, 10-20 parts ethanol, and 60-80 parts water. The active ingredient is a mixture of methylxanthine, artichoke extract, and fructan, in a mass ratio of (2-4):1:2; The mixture of methylxanthines is a combination of 3,7-dimethylxanthine, 1,7-dimethylxanthine, 7-methylxanthine, and 1,3,7-trimethylxanthine in a mass ratio of (0.5-2):(0.5-1):(0.5-0.8):2; The solvent is 1-chloro-3,3,3-trifluoropropene, and the 1-chloro-3,3,3-trifluoropropene is trans-1-chloro-3,3,3-trifluoropropene; The skin conditioning agent is a high-purity elastomeric gel purchased from Kobo Products, Inc., brand name CareSil™ CES-1104; The propellant is selected from tetrafluoropropylene; The softener is a compound of dodecyl lactate, polyester lactate, and hexadecyl lactate, and its brand name is Ceraphyl. TM 31ester.
2. The aerosol according to claim 1, characterized in that, The cellulose is selected from one or more of hydroxymethyl cellulose, hydroxyethyl cellulose, and hydroxypropyl methyl cellulose.
3. The aerosol according to claim 2, characterized in that, The moisturizer is selected from one or more of propylene glycol, dipropylene glycol, glycerin, hyaluronic acid, polyethylene glycol, and sorbitol.
4. The aerosol according to claim 2, characterized in that, The emulsifier is selected from one or more of Tween-20, cholesterol polyether-24, Tween-85, peanut alcohol, oleyl alcohol polyether-2, and polyglycerol-6-dioleate.
5. The aerosol according to claim 2, characterized in that, The preservative is a compound preservative of phenoxyethanol and ethylhexylglycerin.
6. A method for preparing the aerosol according to any one of claims 1-5, characterized in that, Includes the following steps: (1) The functional components are mixed with fragrance and solvent to obtain liquid 1; (2) Pack the liquid material 1 and the propellant into aerosol cans according to the mass ratio, and the test is qualified.
Citation Information
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