Methods, devices, storage media, and equipment for identifying full-path blockage in dual-impedance channels.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHENZHEN COMEN MEDICAL INSTR
- Filing Date
- 2022-12-23
- Publication Date
- 2026-05-26
Smart Images
Figure CN116106204B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of identification technology, and in particular to an identification method, apparatus, storage medium and device for dual impedance channels with full-length blocked holes. Background Technology
[0002] When detecting microparticles using impedance spectroscopy, an impedance channel (i.e., a small orifice or a gemstone aperture) is immersed in an electrolyte solution. A constant current power supply is applied across the impedance channel. When a microparticle passes through the impedance channel, the voltage across the channel changes; the larger the microparticle, the greater the voltage change. Since cells are also a type of microparticle, blood can be diluted and mixed in a diluent based on the above principle. Then, the change in voltage across the impedance channel can be used to count cells. The diluent is a reagent with conductivity and physiological saline properties. However, when using impedance spectroscopy to detect cells, the impedance channel is a component prone to blockage. For example, debris from the puncture tube or aggregates of large protein molecules in the blood may adhere to the inner wall of the impedance channel, causing complete blockage and preventing cell counting. Therefore, it is necessary to identify whether the impedance channel is completely blocked.
[0003] In existing technologies, when identifying whether a full-length impedance channel is blocked, the voltage of the impedance channel at startup is usually used as a reference voltage. The voltage change of the impedance channel is then used to determine whether a full-length impedance channel is blocked. If the voltage of the impedance channel does not change but is significantly higher than the reference voltage, it is determined that the impedance channel is blocked. However, when there is a significant difference between the temperature of the diluent and the temperature at startup, the conductivity of the diluent is different at different temperatures, which makes the reference voltage at startup meaningless, thus failing to accurately identify whether a full-length impedance channel is blocked. Summary of the Invention
[0004] Based on this, it is necessary to propose a method, device, storage medium and equipment for identifying full-length through-hole blockage of dual impedance channels to address the above problems. This allows for accurate identification of whether full-length through-hole blockage of the impedance channel, ensures that the voltage of the impedance channel is not affected by temperature, and solves the problem of false alarms of full-length through-hole blockage of the impedance channel.
[0005] To achieve the above objectives, the present invention provides, in a first aspect, a method for identifying full-length blocked vias in a dual-impedance channel, the method comprising:
[0006] A functional relationship between erythrocyte impedance channel voltage and leukocyte impedance channel voltage was established based on the erythrocyte impedance channel voltage and leukocyte impedance channel voltage at different temperatures;
[0007] Obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature;
[0008] The target leukocyte impedance channel voltage is obtained based on the current erythrocyte impedance channel voltage and the functional relationship.
[0009] Determine the absolute value of the difference between the current leukocyte impedance channel voltage and the target leukocyte impedance channel voltage;
[0010] If the absolute value of the difference is greater than or equal to the first preset threshold and the difference is less than 0, then output the full-process blockage information of the red blood cell impedance channel;
[0011] If the absolute value of the difference is greater than or equal to the first preset threshold, and the difference is greater than 0, then output the full-process blockage information of the leukocyte impedance channel.
[0012] Optionally, the red blood cell impedance channel voltage and white blood cell impedance channel voltage at different temperatures are obtained by the following method:
[0013] At each temperature, red blood cell diluent was perfused into the red blood cell analysis chamber, and white blood cell diluent was perfused into the white blood cell analysis chamber. The red blood cell impedance channel voltage was measured through the electrodes in the red blood cell analysis chamber, and the white blood cell impedance channel voltage was measured through the electrodes in the white blood cell analysis chamber, thus obtaining the red blood cell impedance channel voltage and white blood cell impedance channel voltage at the different temperatures.
[0014] Optionally, establishing the functional relationship between the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage based on the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage at different temperatures includes:
[0015] The least squares method was used to establish the functional relationship based on the red blood cell impedance channel voltage and white blood cell impedance channel voltage at different temperatures.
[0016] Optionally, the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at the current temperature are obtained in the following manner:
[0017] At the current temperature, red blood cell dilution reagent is perfused into the red blood cell analysis pool, and white blood cell dilution reagent is perfused into the white blood cell analysis pool. The current red blood cell impedance channel voltage is measured through the electrodes in the red blood cell analysis pool, and the current white blood cell impedance channel voltage is measured through the electrodes in the white blood cell analysis pool, so as to obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature.
[0018] Optionally, the method further includes:
[0019] If the absolute value of the difference is less than the first preset threshold, then output the information on the full-length plugging of the impedance-free channel.
[0020] To achieve the above objectives, the present invention provides a method for identifying full-length blocked vias in a dual-impedance channel in a second aspect, the method comprising:
[0021] Based on the red blood cell impedance channel voltage and white blood cell impedance channel voltage at different temperatures, establish a linear function of red blood cell impedance channel voltage and white blood cell impedance channel voltage in a rectangular coordinate system;
[0022] Obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature;
[0023] Determine the function points of the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage in the rectangular coordinate system;
[0024] Calculate the linear distance between the function point and the function line;
[0025] If the straight line distance is greater than or equal to the second preset threshold, and the function point is located below the function line, then output the full-length pore blockage information of the red blood cell impedance channel;
[0026] If the straight line distance is greater than or equal to the second preset threshold, and the function point is located above the function line, then output the full-length clogging information of the leukocyte impedance channel.
[0027] To achieve the above objectives, the present invention provides, in a third aspect, a device for identifying dual-impedance channel full-length blocked vias, the device comprising:
[0028] The function relationship determination module is used to establish the functional relationship between the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage based on the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage at different temperatures;
[0029] The first module for acquiring the current voltage is used to acquire the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature;
[0030] The target voltage module is determined, and the target white blood cell impedance channel voltage is obtained based on the current red blood cell impedance channel voltage and the functional relationship.
[0031] The difference determination module is used to determine the absolute value of the difference between the current leukocyte impedance channel voltage and the target leukocyte impedance channel voltage;
[0032] The first hole blockage difference judgment module is used to output the hole blockage information of the red blood cell impedance channel if the absolute value of the difference is greater than or equal to the first preset threshold and the difference is less than 0.
[0033] The second clogging difference judgment module is used to output the clogging information of the leukocyte impedance channel if the absolute value of the difference is greater than or equal to the first preset threshold and the difference is greater than 0.
[0034] To achieve the above objectives, the present invention provides, in a fourth aspect, a device for identifying dual-impedance channel full-length blocked vias, the device comprising:
[0035] The module for determining the function line is used to establish a function line between the red blood cell impedance channel voltage and the white blood cell impedance channel voltage in a rectangular coordinate system based on the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at different temperatures.
[0036] The second module for obtaining the current voltage is used to obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature;
[0037] The function point determination module is used to determine the function points of the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage in the rectangular coordinate system;
[0038] A straight-line distance calculation module is used to calculate the straight-line distance between the function point and the function line;
[0039] The first hole-blocking distance judgment module is used to output the hole-blocking information of the entire red blood cell impedance channel if the straight line distance is greater than or equal to the second preset threshold and the function point is located below the function line.
[0040] The second occlusion distance judgment module is used to output occlusion information of the entire white blood cell impedance channel if the straight line distance is greater than or equal to the second preset threshold and the function point is located above the function line.
[0041] To achieve the above objectives, the present invention provides, in a fifth aspect, a computer-readable storage medium storing a computer program that, when executed by a processor, causes the processor to perform the steps of the method as described in either the first or second aspect.
[0042] To achieve the above objectives, the present invention provides a computer device in a sixth aspect, including a memory and a processor, the memory storing a computer program that, when executed by the processor, causes the processor to perform the steps of the method as described in either the first or second aspect.
[0043] The present invention provides the following advantages: The method establishes a functional relationship between the erythrocyte and leukocyte impedance channel voltages at different temperatures. It obtains the current erythrocyte and leukocyte impedance channel voltages at the current temperature and calculates the target leukocyte impedance channel voltage based on the current erythrocyte impedance channel voltage and the functional relationship. Then, it compares the absolute value of the difference between the leukocyte and target leukocyte impedance channel voltages with a first preset threshold to determine if a full-length impedance channel blockage has occurred. When the absolute value of the difference is greater than or equal to the first preset threshold and less than 0, it outputs information indicating a full-length erythrocyte impedance channel blockage. Similarly, when the absolute value of the difference is greater than or equal to the first preset threshold and greater than 0, it outputs information indicating a full-length leukocyte impedance channel blockage. This method ensures that the voltage of the impedance channel is independent of temperature, accurately identifies whether a full-length impedance channel blockage has occurred, and solves the problem of false alarms about full-length impedance channel blockage. Attached Figure Description
[0044] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0045] in:
[0046] Figure 1 This is a schematic diagram of impedance method for cell detection in an embodiment of this application;
[0047] Figure 2 This is a flowchart illustrating the method for identifying the full-length blocked hole in the dual-impedance channel in an embodiment of this application.
[0048] Figure 3 This is a schematic diagram of the red blood cell impedance channel voltage and white blood cell impedance channel voltage at eight different temperatures in the embodiments of this application;
[0049] Figure 4 This is another flowchart illustrating the method for identifying the full-length blocked hole of the dual impedance channel in the embodiments of this application;
[0050] Figure 5 This is a schematic diagram of the function lines of the red blood cell impedance channel voltage and white blood cell impedance channel voltage at eight temperatures in the embodiments of this application in a rectangular coordinate system;
[0051] Figure 6This is a schematic diagram showing the complete blockage of the red blood cell impedance channel in a rectangular coordinate system in an embodiment of this application;
[0052] Figure 7 This is a schematic diagram showing the complete blockage of the leukocyte impedance channel in a rectangular coordinate system in an embodiment of this application;
[0053] Figure 8 This is a schematic diagram of the identification device for full-length hole blocking of dual impedance channels in the embodiments of this application;
[0054] Figure 9 This is another schematic diagram of the identification device for full-length blockage of dual impedance channels in the embodiments of this application;
[0055] Figure 10 This is a diagram showing the internal structure of a computer device in some embodiments. Detailed Implementation
[0056] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0057] In the embodiments of this application, the identification of complete blockage of dual impedance channels is generally used for analyzers with dual impedance channels (the same applies if two analyzers with single impedance channels are used). When using the analyzer to count cells, it is used to identify whether the impedance channels (i.e., orifices or sapphire holes) in the analyzer are completely blocked.
[0058] Taking a blood cell analyzer as an example, when counting white blood cells, red blood cells, and platelets, the analyzer generally processes the samples in the following way to obtain white blood cell diluent (for counting white blood cells) and red blood cell diluent (for counting red blood cells and platelets): The collected blood sample is divided into two parts. One part of the blood sample is diluted and hemolyzed using a diluent to obtain white blood cell diluent, and the other part of the blood sample is diluted using a diluent to obtain red blood cell diluent. The purpose of hemolysis in the obtained white blood cell diluent is... To dissolve red blood cells and platelets in a blood sample, leaving only white blood cells in the leukocyte diluent; the resulting erythrocyte diluent is not hemolyzed to dissolve white blood cells in the blood sample, leaving only red blood cells and platelets. This is because white blood cells are two to three orders of magnitude smaller than red blood cells and platelets, meaning red blood cells and platelets are thousands of times larger than white blood cells, and the dilution factor of the leukocyte diluent is much smaller than that of the erythrocyte diluent. Therefore, the white blood cells in the erythrocyte diluent can be ignored.
[0059] Please see Figure 1 The diagram below illustrates the impedance method for cell detection in this embodiment. Cell dilution reagent is infused into the cell analysis chamber. Under constant negative pressure, when cells pass through the impedance channel associated with the cell analysis chamber, the impedance channel voltage changes. The impedance channel voltage can be measured by electrodes in the cell analysis chamber to count the cells.
[0060] In this embodiment, the method for identifying the complete blockage of the dual-impedance channel is applied to a blood cell analyzer with dual impedance channels. This analyzer has two cell analysis pools: a white blood cell analysis pool and a red blood cell analysis pool. Therefore, after obtaining the white blood cell diluent and the red blood cell diluent, the white blood cell diluent is injected into the white blood cell analysis pool of the blood cell analyzer, and the red blood cell diluent is injected into the red blood cell analysis pool. Under constant negative pressure, when white blood cells pass through the white blood cell impedance channel associated with the white blood cell analysis pool, the voltage of the white blood cell impedance channel changes. This voltage can be measured by electrodes in the white blood cell analysis pool to count the white blood cells. Similarly, when red blood cells and platelets pass through the red blood cell impedance channel associated with the red blood cell analysis pool, the voltage of the red blood cell impedance channel changes. This voltage can also be measured by electrodes in the red blood cell analysis pool to count the red blood cells and platelets.
[0061] When leukocytes pass through the leukocyte impedance channel associated with the leukocyte analysis pool, and when erythrocytes and platelets pass through the erythrocyte impedance channel associated with the erythrocyte analysis pool, if puncture debris or large protein molecules adhere to the impedance channels (leukocyte impedance channel and erythrocyte impedance channel) during the measurement phase, the impedance channels will experience impedance throughout the measurement, resulting in incorrect impedance channel voltage data for this measurement and preventing cell counting. If puncture debris or large protein molecules adhere to the impedance channels at the end of the measurement phase, the impedance channels will also experience impedance throughout the measurement, but this will cause incorrect impedance channel voltage data for the next measurement, preventing cell counting for the next measurement.
[0062] To accurately determine whether the leukocyte impedance channel and the erythrocyte impedance channel have experienced complete blockage, the identification method for complete blockage of dual impedance channels in the following embodiments will be used to accurately determine whether the leukocyte impedance channel and the erythrocyte impedance channel have experienced complete blockage.
[0063] Please see Figure 2 This is a flowchart illustrating the method for identifying the full-length blocked via of a dual-impedance channel in an embodiment of this application. The method includes:
[0064] Step 210: Establish the functional relationship between the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage based on the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage at different temperatures.
[0065] Here, "different temperatures" refers to the temperatures of the erythrocyte dilution reagent and the leukocyte dilution reagent, i.e., the various ambient temperatures that may be encountered when measuring the erythrocyte impedance channel voltage of the erythrocyte dilution reagent and the leukocyte impedance channel voltage of the leukocyte dilution reagent. By measuring the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage at various ambient temperatures, the erythrocyte impedance channel voltage R at different temperatures can be obtained, thereby establishing the erythrocyte impedance channel voltage R. n With leukocyte impedance channel voltage W n Functional relationship W n =f(R) n ), where n represents temperature. It can be understood that each temperature corresponds to a red blood cell impedance channel voltage R. n and white blood cell impedance channel voltage W n .
[0066] It should be noted that the preferred temperature in this scheme is because the conductivity of the diluent varies at different temperatures. This means that the obtained red blood cell impedance channel voltage and white blood cell impedance channel voltage may be inaccurate due to the influence of ambient temperature. Therefore, different ambient temperatures are used to establish the functional relationship in order to eliminate the influence of ambient temperature on the established functional relationship. In some embodiments, other different environmental conditions can also be used to establish the functional relationship. It is understood that for those skilled in the art, using different temperatures is only a preferred scheme. Therefore, other schemes can be adopted by changing the environmental conditions.
[0067] It should be noted that step 210, which establishes the functional relationship between the red blood cell impedance channel voltage and the white blood cell impedance channel voltage, is a pre-set step. After the functional relationship is established for the first time, it is not necessary to repeat the establishment of the functional relationship when identifying the full-process blockage of the dual impedance channel.
[0068] Step 220: Obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature.
[0069] Here, "current temperature" refers to the current temperature of the red blood cell diluent and the white blood cell diluent. It can be understood that the temperatures of the red blood cell diluent and the white blood cell diluent are equal at the current temperature. The red blood cell impedance channel voltage of the red blood cell diluent and the white blood cell impedance channel voltage of the white blood cell diluent measured at the current temperature are the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage.
[0070] It should be noted that, correspondingly, if the different temperatures in step 210 are based on other different environmental conditions, then the current temperature in step 220 is based on other current environmental conditions.
[0071] Step 230: Obtain the target white blood cell impedance channel voltage based on the current red blood cell impedance channel voltage and the functional relationship.
[0072] In some embodiments, after obtaining the current red blood cell impedance channel voltage R 当前温度 Then, the current red blood cell impedance channel voltage R 当前温度 Substitute the functional relationship W between the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage. n =f(R) n In this process, the impedance channel voltage W of the target leukocyte can be obtained.
[0073] Step 240: Determine the absolute value of the difference between the current leukocyte impedance channel voltage and the target leukocyte impedance channel voltage.
[0074] In some embodiments, after obtaining the current leukocyte impedance channel voltage W当前温度 After obtaining the target leukocyte impedance channel voltage W, the current leukocyte impedance channel voltage W can be calculated. 当前温度 The absolute value of the difference between the impedance channel voltage W of the target leukocyte and the impedance channel voltage W is ΔW = W 当前温度 -W is used to determine whether an impedance path has been completely blocked based on the value of ΔW.
[0075] Step 250: If the absolute value of the difference is greater than or equal to the first preset threshold and the difference is less than 0, then output the full-process blockage information of the red blood cell impedance channel.
[0076] The first preset threshold is obtained by the operator based on historical data analysis or a large number of experiments. It can be set by the operator according to actual needs. It can be understood that the first preset threshold is the maximum allowable fluctuation range of the measured leukocyte impedance channel voltage. That is, within the maximum allowable fluctuation range of the leukocyte impedance channel voltage, the impedance channel will not be completely blocked. Furthermore, the first preset threshold is a positive integer greater than 0. Therefore, when the absolute value of the difference is greater than or equal to the first preset threshold, the difference will not be equal to 0.
[0077] In some embodiments, the information on the complete blockage of the red blood cell impedance channel can be displayed on a screen or given a voice prompt through a speaker. It is understood that the purpose of outputting the information on the complete blockage of the red blood cell impedance channel is to prompt the operator that the red blood cell impedance channel has been completely blocked.
[0078] Step 260: If the absolute value of the difference is greater than or equal to the first preset threshold and the difference is greater than 0, then output the full-process pore blockage information of the leukocyte impedance channel.
[0079] In some embodiments, the information on the complete blockage of the leukocyte impedance channel can be displayed on a screen or given a voice prompt through a speaker. It is understood that the purpose of outputting the information on the complete blockage of the leukocyte impedance channel is to inform the operator that the leukocyte impedance channel has been completely blocked.
[0080] In another feasible implementation, the positions of the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage in the functional relationship can be adjusted to establish the leukocyte impedance channel voltage W based on the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage at different temperatures. n With the red blood cell impedance channel voltage R n Functional relationship R n =f(W n ), obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature, and based on the current white blood cell impedance channel voltage W 当前温度 Relationship between functions Rn =f(W n The target red blood cell impedance channel voltage R is obtained, and the current red blood cell impedance channel voltage R is determined. 当前温度 The absolute value of the difference between the impedance channel voltage R of the target red blood cell and the impedance channel voltage R is ΔR = R 当前温度 -R, if the absolute value of the difference is greater than or equal to the third preset threshold and the difference is less than 0, output the full-process pore blockage information of the white blood cell impedance channel; if the absolute value of the difference is greater than or equal to the third preset threshold and the difference is greater than 0, output the full-process pore blockage information of the red blood cell impedance channel.
[0081] In this embodiment, a functional relationship between the red blood cell impedance channel voltage and the white blood cell impedance channel voltage is established based on the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at different temperatures. The current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature are obtained, and the target white blood cell impedance channel voltage is obtained based on the current red blood cell impedance channel voltage and the functional relationship. Then, the absolute value of the difference between the white blood cell impedance channel voltage and the target white blood cell impedance channel voltage is compared with a first preset threshold to determine whether a full-length impedance channel blockage has occurred. When the absolute value of the difference is greater than or equal to the first preset threshold and the difference is less than 0, information indicating full-length red blood cell impedance channel blockage is output, indicating that a full-length red blood cell impedance channel blockage has occurred. When the absolute value of the difference is greater than or equal to the first preset threshold and the difference is greater than 0, information indicating full-length white blood cell impedance channel blockage is output, indicating that a full-length white blood cell impedance channel blockage has occurred. This method ensures that the voltage of the impedance channel is independent of temperature, accurately identifies whether a full-length impedance channel blockage has occurred, and solves the problem of false alarms about full-length impedance channel blockage.
[0082] In one feasible implementation, in step 210, the erythrocyte impedance channel voltage and leukocyte impedance channel voltage at different temperatures are obtained by: perfusing erythrocyte dilution reagent into the erythrocyte analysis cell and leukocyte dilution reagent into the leukocyte analysis cell at each temperature; measuring the erythrocyte impedance channel voltage through electrodes in the erythrocyte analysis cell and measuring the leukocyte impedance channel voltage through electrodes in the leukocyte analysis cell, thereby obtaining the erythrocyte impedance channel voltage and leukocyte impedance channel voltage at different temperatures.
[0083] In some embodiments, since the temperature of erythrocyte diluent and leukocyte diluent is generally between 10°C and 35°C, erythrocyte impedance channel voltage and leukocyte impedance channel voltage can be measured using erythrocyte diluent and leukocyte diluent at eight temperature steps: 5°C, 10°C, 15°C, 20°C, 25°C, 30°C, 35°C, and 40°C. This yields erythrocyte impedance channel voltage and leukocyte impedance channel voltage at eight temperature steps. Specifically, at 5°C, erythrocyte diluent is perfused into the erythrocyte analysis chamber, and leukocyte diluent is perfused into the leukocyte analysis chamber. The erythrocyte impedance channel voltage is then measured using erythrocyte diluent. The red blood cell impedance channel voltage is measured using electrodes in the analysis cell, and the white blood cell impedance channel voltage is measured using electrodes in the white blood cell analysis cell, yielding the red blood cell impedance channel voltage and white blood cell impedance channel voltage at 5 degrees Celsius. At 10 degrees Celsius, red blood cell diluent is infused into the red blood cell analysis cell, and white blood cell diluent is infused into the white blood cell analysis cell. The red blood cell impedance channel voltage is measured using electrodes in the red blood cell analysis cell, and the white blood cell impedance channel voltage is measured using electrodes in the white blood cell analysis cell, yielding the red blood cell impedance channel voltage and white blood cell impedance channel voltage at 10 degrees Celsius. This process is repeated until the red blood cell impedance channel voltage and white blood cell impedance channel voltage at eight temperature steps are obtained. For an example, please refer to [reference needed]. Figure 3 This is a schematic diagram of the red blood cell impedance channel voltage and white blood cell impedance channel voltage at eight different temperatures in the embodiments of this application.
[0084] It should be noted that after measuring the red blood cell impedance channel voltage and white blood cell impedance channel voltage at a certain temperature, the red blood cell analysis cell and white blood cell analysis cell need to be emptied and cleaned before the next temperature measurement can be performed. This is understandably to avoid the influence of the previous temperature on the measurement of the next temperature.
[0085] In this embodiment, by perfusing red blood cell diluent into the red blood cell analysis pool and white blood cell diluent into the white blood cell analysis pool at each temperature, and measuring the red blood cell impedance channel voltage through electrodes in the red blood cell analysis pool and the white blood cell impedance channel voltage through electrodes in the white blood cell analysis pool, the red blood cell impedance channel voltage and white blood cell impedance channel voltage at different temperatures are obtained. This ensures that there is a corresponding red blood cell impedance channel voltage and white blood cell impedance channel voltage at each temperature gradient. This facilitates the establishment of a functional relationship between the red blood cell impedance channel voltage and the white blood cell impedance channel voltage, thereby ensuring that the voltage of the impedance channel is independent of the temperature and solving the problem of false alarms due to complete blockage of the impedance channel.
[0086] In one feasible implementation, in step 210, a functional relationship between the red blood cell impedance channel voltage and the white blood cell impedance channel voltage is established based on the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at different temperatures, including: using the least squares method to establish the functional relationship between the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at different temperatures.
[0087] It should be noted that the least squares method is a mathematical optimization algorithm, which has been described in detail in existing technologies and will not be repeated here. Essentially, the least squares method finds the optimal function match for the data by minimizing the sum of squared errors. In some embodiments, the optimal function W is obtained using sample data from eight temperature gradients (red blood cell impedance channel voltage and white blood cell impedance channel voltage). n =a×R n +b (i.e., W) n =0.8262×R n +131.32), to use the optimal function to solve for the unknown data (i.e., the target leukocyte impedance channel voltage) so that the sum of squares of the errors between the solved data and the actual data is minimized.
[0088] In this embodiment, by using the least squares method to establish a functional relationship between the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at different temperatures, the sum of squares between the target white blood cell impedance channel voltage and the actual current white blood cell impedance channel voltage can be minimized, thereby enabling accurate identification of whether the impedance channel is completely blocked.
[0089] In one feasible implementation, in step 220, the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at the current temperature are obtained by: at the current temperature, red blood cell diluent is infused into the red blood cell analysis pool, white blood cell diluent is infused into the white blood cell analysis pool, the current red blood cell impedance channel voltage is measured through the electrodes in the red blood cell analysis pool, and the current white blood cell impedance channel voltage is measured through the electrodes in the white blood cell analysis pool, thereby obtaining the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature.
[0090] In this embodiment, red blood cell diluent is infused into the red blood cell analysis pool and white blood cell diluent into the white blood cell analysis pool at the current temperature. The current red blood cell impedance channel voltage is measured by electrodes in the red blood cell analysis pool, and the current white blood cell impedance channel voltage is measured by electrodes in the white blood cell analysis pool. The current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature are obtained. Based on the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage, as well as the functional relationship, it is determined whether there is complete blockage of the impedance channel, so as to avoid obtaining inaccurate impedance channel voltages, thereby making it impossible to count cells.
[0091] In one feasible implementation, the method in the above embodiments further includes: if the absolute value of the difference is less than a first preset threshold, then output the information on the full-length plugging of the impedance-free channel.
[0092] In some embodiments, the information on the blockage of the output impedance-free channel can be displayed on a screen or given a voice prompt through a speaker.
[0093] In this embodiment, when the absolute value of the difference is less than a first preset threshold, information about the complete blockage of the impedance channel is output to remind the operator that neither the white blood cell impedance channel nor the red blood cell impedance channel has been completely blocked.
[0094] Please see Figure 4 This is another flowchart illustrating the method for identifying the full-length blocked via of the dual-impedance channel in this application embodiment. The method includes:
[0095] Step 410: Based on the red blood cell impedance channel voltage and white blood cell impedance channel voltage at different temperatures, establish a linear function of red blood cell impedance channel voltage and white blood cell impedance channel voltage in a rectangular coordinate system.
[0096] It should be noted that the erythrocyte impedance channel voltage and leukocyte impedance channel voltage at different temperatures can be obtained by the following method described in the above embodiment: "At each temperature, erythrocyte dilution reagent is perfused into the erythrocyte analysis cell, leukocyte dilution reagent is perfused into the leukocyte analysis cell, and erythrocyte impedance channel voltage is measured through the electrodes in the erythrocyte analysis cell and leukocyte impedance channel voltage is measured through the electrodes in the leukocyte analysis cell to obtain the erythrocyte impedance channel voltage and leukocyte impedance channel voltage at different temperatures." This will not be elaborated further here.
[0097] It should be further noted that, in some embodiments, the process of establishing a linear function of erythrocyte and leukocyte impedance channel voltages in a Cartesian coordinate system based on erythrocyte and leukocyte impedance channel voltages at different temperatures can be achieved by using the least squares method described in the above embodiments to obtain the functional relationship W. n=a×R n The values of 'a' and 'b' in +b are used to establish a linear function representing the red blood cell impedance channel voltage and the white blood cell impedance channel voltage in a rectangular coordinate system. In other embodiments, a scatter plot of the red blood cell impedance channel voltage and the white blood cell impedance channel voltage can be plotted in a rectangular coordinate system, and then the linear function can be determined based on the distance between the scatter plots. For example, using... Figure 3 The function line obtained from 8 temperature data points is shown in the image. Figure 5 This is a schematic diagram of the function lines of the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at eight temperatures in the embodiments of this application in a rectangular coordinate system.
[0098] It should also be noted that step 410 corresponds to step 210. That is, the process of establishing the functional straight line of the red blood cell impedance channel voltage and the white blood cell impedance channel voltage is also a preset step. After the functional straight line is established for the first time, it is not necessary to repeat the functional straight line when identifying the full-length blockage of the dual impedance channel.
[0099] Step 420: Obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature.
[0100] It should be noted that, to obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature, step 220 in the above embodiment can be used, or the above embodiment can be described as follows: "At the current temperature, red blood cell diluent is injected into the red blood cell analysis pool, white blood cell diluent is injected into the white blood cell analysis pool, the current red blood cell impedance channel voltage is measured through the electrodes in the red blood cell analysis pool, and the current white blood cell impedance channel voltage is measured through the electrodes in the white blood cell analysis pool to obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature." This will not be elaborated further here.
[0101] Step 430: Determine the function points of the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage in the rectangular coordinate system.
[0102] In some embodiments, the current red blood cell impedance channel voltage R is obtained. 当前温度 With the current leukocyte impedance channel voltage W 当前温度 Then, the function point (R) can be determined based on the distance between the X and Y axes in the rectangular coordinate system. 当前温度 W 当前温度 ).
[0103] Step 440: Calculate the linear distance between the function point and the function line.
[0104] In some embodiments, the distance formula from a point to a line can be used to calculate the linear distance between a function point and a function line.
[0105] Step 450: If the straight-line distance is greater than or equal to the second preset threshold, and the function point is located below the function line, then output the full-length pore blockage information of the red blood cell impedance channel.
[0106] The second preset threshold is obtained by the operator based on historical data analysis or a large number of experiments. It can be set by the operator according to actual needs. It can be understood that the second preset threshold is the maximum allowable fluctuation range of the measured leukocyte impedance channel voltage. That is, within the maximum allowable fluctuation range of the leukocyte impedance channel voltage, the impedance channel will not be completely blocked. Furthermore, the second preset threshold is a positive integer greater than 0.
[0107] In some embodiments, the information on the complete blockage of the red blood cell impedance channel can be displayed on a screen or given a voice prompt through a speaker. It is understood that the purpose of outputting the information on the complete blockage of the red blood cell impedance channel is to prompt the operator that the red blood cell impedance channel has been completely blocked.
[0108] In some embodiments, for example, see Figure 6 This is a schematic diagram of the red blood cell impedance channel being completely blocked in a rectangular coordinate system in an embodiment of this application.
[0109] Step 460: If the straight-line distance is greater than or equal to the second preset threshold, and the function point is located above the function line, then output the full-length pore blockage information of the leukocyte impedance channel.
[0110] In some embodiments, the information on the complete blockage of the leukocyte impedance channel can be displayed on a screen or given a voice prompt through a speaker. It is understood that the purpose of outputting the information on the complete blockage of the leukocyte impedance channel is to inform the operator that the leukocyte impedance channel has been completely blocked.
[0111] In some embodiments, for example, see Figure 7 This is a schematic diagram of the leukocyte impedance channel being completely blocked in a rectangular coordinate system in an embodiment of this application.
[0112] In another feasible implementation, corresponding to the above embodiment, the X-axis and Y-axis positions of the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage in a rectangular coordinate system can be adjusted. This allows the establishment of a linear function between the leukocyte impedance channel voltage and the erythrocyte impedance channel voltage at different temperatures. The current erythrocyte impedance channel voltage and the current leukocyte impedance channel voltage at the current temperature are obtained. The function point of the current leukocyte impedance channel voltage and the current erythrocyte impedance channel voltage in the rectangular coordinate system is determined. The linear distance between the function point and the function line is calculated. If the linear distance is greater than or equal to a fourth preset threshold, and the function point is below the function line, then the full-length leukocyte impedance channel blockage information is output. If the linear distance is greater than or equal to the fourth preset threshold, and the function point is above the function line, then the full-length erythrocyte impedance channel blockage information is output. It is understood that other variations can also be used, which will not be elaborated here. Simple modifications using the embodiments of this application are also part of the content of the embodiments of this application.
[0113] In this embodiment, a linear function of the red blood cell impedance channel voltage and the white blood cell impedance channel voltage is established based on the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at different temperatures. The current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature are obtained, and the function point of the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage in the rectangular coordinate system is determined. Then, based on the comparison between the linear distance between the function point and the function line and a second preset threshold, it is determined whether a full-length impedance channel blockage has occurred. When the linear distance is greater than or equal to the second preset threshold, and the function point is below the function line, information on full-length red blood cell impedance channel blockage is output, indicating that a full-length red blood cell impedance channel blockage has occurred. When the linear distance is greater than or equal to the second preset threshold, and the function point is above the function line, information on full-length white blood cell impedance channel blockage is output, indicating that a full-length white blood cell impedance channel blockage has occurred. This method can ensure that the voltage of the impedance channel is independent of temperature, accurately identify whether a full-length impedance channel blockage has occurred, and solve the problem of false alarms about full-length impedance channel blockage.
[0114] In one feasible implementation, the method in the above embodiments further includes: if the straight-line distance is less than a second preset threshold, then outputting information on the full-length plugging of the impedance-free channel.
[0115] In some embodiments, the information on the blockage of the output impedance-free channel can be displayed on a screen or given a voice prompt through a speaker.
[0116] In this embodiment of the application, when the straight-line distance is less than the second preset threshold, the information of full blockage of the impedance channel is output to remind the operator that neither the white blood cell impedance channel nor the red blood cell impedance channel has been fully blocked.
[0117] Please see Figure 8 This is a schematic diagram of the identification device for full-length plugging of dual impedance channels in an embodiment of this application. The 810 device includes:
[0118] The function relationship determination module 811 is used to establish the function relationship between the red blood cell impedance channel voltage and the white blood cell impedance channel voltage based on the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at different temperatures;
[0119] The first current voltage acquisition module 812 is used to acquire the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature;
[0120] The target voltage module 813 is determined, and the target white blood cell impedance channel voltage is obtained based on the current red blood cell impedance channel voltage and the functional relationship.
[0121] The difference determination module 814 is used to determine the absolute value of the difference between the current leukocyte impedance channel voltage and the target leukocyte impedance channel voltage;
[0122] The first hole blockage difference judgment module 815 is used to output the hole blockage information of the red blood cell impedance channel if the absolute value of the difference is greater than or equal to the first preset threshold and the difference is less than 0.
[0123] The second occlusion difference judgment module 816 is used to output the occlusion information of the entire white blood cell impedance channel if the absolute value of the difference is greater than or equal to the first preset threshold and the difference is greater than 0.
[0124] In this embodiment, the relevant contents of the above-mentioned function relationship determination module 811, first current voltage acquisition module 812, target voltage determination module 813, difference determination module 814, first hole plugging difference judgment module 815, and second hole plugging difference judgment module 816 can be found in the following references. Figure 2 The contents of the illustrated embodiments will not be repeated here.
[0125] In this embodiment, a functional relationship between the red blood cell impedance channel voltage and the white blood cell impedance channel voltage is established based on the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at different temperatures. The current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature are obtained, and the target white blood cell impedance channel voltage is obtained based on the current red blood cell impedance channel voltage and the functional relationship. Then, the absolute value of the difference between the white blood cell impedance channel voltage and the target white blood cell impedance channel voltage is compared with a first preset threshold to determine whether a full-length impedance channel blockage has occurred. When the absolute value of the difference is greater than or equal to the first preset threshold and the difference is less than 0, information indicating full-length red blood cell impedance channel blockage is output, indicating that a full-length red blood cell impedance channel blockage has occurred. When the absolute value of the difference is greater than or equal to the first preset threshold and the difference is greater than 0, information indicating full-length white blood cell impedance channel blockage is output, indicating that a full-length white blood cell impedance channel blockage has occurred. This method ensures that the voltage of the impedance channel is independent of temperature, accurately identifies whether a full-length impedance channel blockage has occurred, and solves the problem of false alarms about full-length impedance channel blockage.
[0126] Please see Figure 9 This is another schematic diagram of the identification device for full-length plugging of dual impedance channels in the embodiments of this application. The 910 device includes:
[0127] The function line module 911 is used to establish a function line between the red blood cell impedance channel voltage and the white blood cell impedance channel voltage in a rectangular coordinate system based on the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at different temperatures.
[0128] The second current voltage acquisition module 912 is used to acquire the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature;
[0129] The function point determination module 913 is used to determine the function points of the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage in a rectangular coordinate system.
[0130] The straight-line distance calculation module 914 is used to calculate the straight-line distance between a function point and a function line;
[0131] The first hole-blocking distance judgment module 915 is used to output the hole-blocking information of the entire red blood cell impedance channel if the straight line distance is greater than or equal to the second preset threshold and the function point is located below the function line.
[0132] The second occlusion distance judgment module 916 is used to output the occlusion information of the entire white blood cell impedance channel if the straight line distance is greater than or equal to the second preset threshold and the function point is located above the function line.
[0133] In this embodiment, the relevant contents of the above-mentioned function line determination module 911, the second current voltage acquisition module 912, the function point determination module 913, the line distance calculation module 914, the first hole-blocking distance judgment module 915, and the second hole-blocking distance judgment module 916 can be found in the following references. Figure 4 The contents of the illustrated embodiments will not be repeated here.
[0134] In this embodiment, a linear function of the red blood cell impedance channel voltage and the white blood cell impedance channel voltage is established based on the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at different temperatures. The current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature are obtained, and the function point of the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage in the rectangular coordinate system is determined. Then, based on the comparison between the linear distance between the function point and the function line and a second preset threshold, it is determined whether a full-length impedance channel blockage has occurred. When the linear distance is greater than or equal to the second preset threshold, and the function point is below the function line, information on full-length red blood cell impedance channel blockage is output, indicating that a full-length red blood cell impedance channel blockage has occurred. When the linear distance is greater than or equal to the second preset threshold, and the function point is above the function line, information on full-length white blood cell impedance channel blockage is output, indicating that a full-length white blood cell impedance channel blockage has occurred. This method can ensure that the voltage of the impedance channel is independent of temperature, accurately identify whether a full-length impedance channel blockage has occurred, and solve the problem of false alarms about full-length impedance channel blockage.
[0135] In some embodiments, a computer-readable storage medium is provided, storing a computer program, which, when executed by a processor, causes the processor to perform the identification method for full-length blockage of dual impedance channels in the above method embodiments.
[0136] In some embodiments, a computer device is provided, including a memory and a processor, wherein the memory stores a computer program, and when the computer program is executed by the processor, the processor performs the identification method for full-length blocked dual-impedance channels in the above method embodiments.
[0137] Figure 10 The diagram illustrates the internal structure of a computer device in some embodiments. This computer device may specifically be a terminal, a server, or a gateway. Figure 10 As shown, the computer device includes a processor, memory, and network interface connected via a system bus.
[0138] The memory includes a non-volatile storage medium and internal memory. The non-volatile storage medium of the computer device stores an operating system and may also store a computer program. When executed by a processor, this computer program causes the processor to perform the steps in the above method embodiments. The internal memory may also store a computer program, which, when executed by a processor, causes the processor to perform the steps in the above method embodiments. Those skilled in the art will understand that... Figure 10 The structure shown is merely a block diagram of a portion of the structure related to the present application and does not constitute a limitation on the computer device to which the present application is applied. Specific computer devices may include more or fewer components than those shown in the figure, or combine certain components, or have different component arrangements.
[0139] Those skilled in the art will understand that all or part of the processes in the methods of the above embodiments can be implemented by a computer program instructing related hardware. The program can be stored in a non-volatile computer-readable storage medium. When the program is executed, it can include the processes of the embodiments of the above methods.
[0140] Any references to memory, storage, database, or other media used in the embodiments provided in this application may include non-volatile and / or volatile memory. Non-volatile memory may include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM), or flash memory. Volatile memory may include random access memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in various forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), dual data rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous link DRAM (SLDRAM), RAMbus direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and RAMbus dynamic RAM (RDRAM), etc.
[0141] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.
[0142] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of this patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.
Claims
1. A method for identifying a full-length hole of a dual impedance channel, characterized in that, The method includes: A functional relationship between erythrocyte impedance channel voltage and leukocyte impedance channel voltage was established based on the erythrocyte impedance channel voltage and leukocyte impedance channel voltage at different temperatures; Obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature; The target leukocyte impedance channel voltage is obtained based on the current erythrocyte impedance channel voltage and the functional relationship. Determine the absolute value of the difference between the current leukocyte impedance channel voltage and the target leukocyte impedance channel voltage; If the absolute value of the difference is greater than or equal to the first preset threshold and the difference is less than 0, then output the full-process blockage information of the red blood cell impedance channel; If the absolute value of the difference is greater than or equal to the first preset threshold, and the difference is greater than 0, then output the full-process blockage information of the leukocyte impedance channel.
2. The method according to claim 1, characterized in that, The red blood cell impedance channel voltage and white blood cell impedance channel voltage at different temperatures were obtained in the following manner: At each temperature, red blood cell diluent was perfused into the red blood cell analysis chamber, and white blood cell diluent was perfused into the white blood cell analysis chamber. The red blood cell impedance channel voltage was measured through the electrodes in the red blood cell analysis chamber, and the white blood cell impedance channel voltage was measured through the electrodes in the white blood cell analysis chamber, thus obtaining the red blood cell impedance channel voltage and white blood cell impedance channel voltage at the different temperatures.
3. The method according to claim 1, characterized in that, The establishment of a functional relationship between erythrocyte impedance channel voltage and leukocyte impedance channel voltage based on erythrocyte impedance channel voltage and leukocyte impedance channel voltage at different temperatures includes: The least squares method was used to establish the functional relationship based on the red blood cell impedance channel voltage and white blood cell impedance channel voltage at different temperatures.
4. The method according to claim 1, characterized in that, The red blood cell impedance channel voltage and white blood cell impedance channel voltage at the current temperature are obtained as follows: At the current temperature, red blood cell dilution reagent is perfused into the red blood cell analysis pool, and white blood cell dilution reagent is perfused into the white blood cell analysis pool. The current red blood cell impedance channel voltage is measured through the electrodes in the red blood cell analysis pool, and the current white blood cell impedance channel voltage is measured through the electrodes in the white blood cell analysis pool, so as to obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature.
5. The method according to claim 1, characterized in that, The method further includes: If the absolute value of the difference is less than the first preset threshold, then output the information on the full-length plugging of the impedance-free channel.
6. A method for identifying full-length blocked holes in a dual-impedance channel, characterized in that, The method includes: Based on the red blood cell impedance channel voltage and white blood cell impedance channel voltage at different temperatures, establish a linear function of red blood cell impedance channel voltage and white blood cell impedance channel voltage in a rectangular coordinate system; Obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature; Determine the function points of the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage in the rectangular coordinate system; Calculate the linear distance between the function point and the function line; If the straight line distance is greater than or equal to the second preset threshold, and the function point is located below the function line, then output the full-length pore blockage information of the red blood cell impedance channel; If the straight line distance is greater than or equal to the second preset threshold, and the function point is located above the function line, then output the full-length clogging information of the leukocyte impedance channel.
7. A device for identifying dual-impedance channel full-length blocked holes, characterized in that, The device includes: The function relationship determination module is used to establish the functional relationship between the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage based on the erythrocyte impedance channel voltage and the leukocyte impedance channel voltage at different temperatures; The first module for acquiring the current voltage is used to acquire the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature; The target voltage module is determined, and the target white blood cell impedance channel voltage is obtained based on the current red blood cell impedance channel voltage and the functional relationship. The difference determination module is used to determine the absolute value of the difference between the current leukocyte impedance channel voltage and the target leukocyte impedance channel voltage; The first hole blockage difference judgment module is used to output the hole blockage information of the red blood cell impedance channel if the absolute value of the difference is greater than or equal to the first preset threshold and the difference is less than 0. The second clogging difference judgment module is used to output the clogging information of the leukocyte impedance channel if the absolute value of the difference is greater than or equal to the first preset threshold and the difference is greater than 0.
8. A device for identifying full-length blocked holes in a dual-impedance channel, characterized in that, The device includes: The module for determining the function line is used to establish a function line between the red blood cell impedance channel voltage and the white blood cell impedance channel voltage in a rectangular coordinate system based on the red blood cell impedance channel voltage and the white blood cell impedance channel voltage at different temperatures. The second module for obtaining the current voltage is used to obtain the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage at the current temperature; The function point determination module is used to determine the function points of the current red blood cell impedance channel voltage and the current white blood cell impedance channel voltage in the rectangular coordinate system; A straight-line distance calculation module is used to calculate the straight-line distance between the function point and the function line; The first hole-blocking distance judgment module is used to output the hole-blocking information of the entire red blood cell impedance channel if the straight line distance is greater than or equal to the second preset threshold and the function point is located below the function line. The second occlusion distance judgment module is used to output occlusion information of the entire white blood cell impedance channel if the straight line distance is greater than or equal to the second preset threshold and the function point is located above the function line.
9. A computer-readable storage medium, characterized in that, The system stores a computer program that, when executed by a processor, causes the processor to perform the steps of the method as described in any one of claims 1 to 6.
10. A computer device, characterized in that, It includes a memory and a processor, the memory storing a computer program that, when executed by the processor, causes the processor to perform the steps of the method as described in any one of claims 1 to 6.